Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2023

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 9781 - 9810 of 35274

Full-Text Articles in Entire DC Network

M²Brtpc: A Novel Modified Multimodal Biometric Recognition For Toddlers And Pre-School Children Approach, Mahmoud Bahzad, Labib M. Labib, Mostafa Elhosseini, Mahmoud Badawy Aug 2023

M²Brtpc: A Novel Modified Multimodal Biometric Recognition For Toddlers And Pre-School Children Approach, Mahmoud Bahzad, Labib M. Labib, Mostafa Elhosseini, Mahmoud Badawy

Mansoura Engineering Journal

A biometric system based on the characteristics of adults recently achieved an outstanding result. Over the last few decades, many applications have been developed for adults, such as fingerprint, face, iris, and hand-vein. Infant identification suffers from many problems and does not enroll all possible ages. Identifying children using one or any biometric features is the first step in ensuring that they are recognized before the law and that their rights are guaranteed. From another perspective, this prevents baby swaps in hospitals, Identifying Missing Children, and Civil ID Programs. This paper introduces an approach for Multimodal Biometric Recognition for Toddlers …


2023-2024 Median Earnings Four Years After Graduation From Unlv & Unr, Isabelle G. Graham, Emily J. Daclan, Caitlin J. Saladino, William E. Brown Jr. Aug 2023

2023-2024 Median Earnings Four Years After Graduation From Unlv & Unr, Isabelle G. Graham, Emily J. Daclan, Caitlin J. Saladino, William E. Brown Jr.

Higher Education

This fact sheet presents data from The HEA Group examining 2023-2024 median earnings four years after graduating with a bachelor’s degree from the University of Nevada, Las Vegas (UNLV) and the University of Nevada, Reno (UNR). Median earnings are presented for the following undergraduate areas of study: business; hospitality; fine arts; education; engineering; medical; sciences and mathematics; and social sciences and humanities.


Changes In An Enzyme Ensemble During Catalysis Observed By High Resolution Xfel Crystallography, Nathan J. Smith, Medhanjali Dasgupta, David C. Wych, Cole Dolamore, Raymond G. Sierra, Stella Lisova, Darya Marchany-Rivera, Aina E. Cohen, Sébastien Boutet, Mark S. Hunter, Christopher Kupitz, Frédéric Poitevin, Frank R. Moss Iii, Aaron S. Brewster, Nicholas K. Sauter, Iris D. Young, Alexander M. Wolff, Virendra K. Tiwari, Nivesh Kumar, David B. Berkowitz, Ryan G. Hadt, Michael C. Thompson, Alec H. Follmer, Mark A. Wilson Aug 2023

Changes In An Enzyme Ensemble During Catalysis Observed By High Resolution Xfel Crystallography, Nathan J. Smith, Medhanjali Dasgupta, David C. Wych, Cole Dolamore, Raymond G. Sierra, Stella Lisova, Darya Marchany-Rivera, Aina E. Cohen, Sébastien Boutet, Mark S. Hunter, Christopher Kupitz, Frédéric Poitevin, Frank R. Moss Iii, Aaron S. Brewster, Nicholas K. Sauter, Iris D. Young, Alexander M. Wolff, Virendra K. Tiwari, Nivesh Kumar, David B. Berkowitz, Ryan G. Hadt, Michael C. Thompson, Alec H. Follmer, Mark A. Wilson

Department of Chemistry: Faculty Publications

Enzymes populate ensembles of structures with intrinsically different catalytic proficiencies that are difficult to experimentally characterize. We use time-resolved mix-and-inject serial crystallography (MISC) at an X-ray free electron laser (XFEL) to observe catalysis in a designed mutant (G150T) isocyanide hydratase (ICH) enzyme that enhances sampling of important minor conformations. The active site exists in a mixture of conformations and formation of the thioimidate catalytic intermediate selects for catalytically competent substates. A prior proposal for active site cysteine charge-coupled conformational changes in ICH is validated by determining structures of the enzyme over a range of pH values. A combination of large …


Assessing Blood Oxygen Level–Dependent Signal Variability As A Biomarker Of Brain Injury In Sport-Related Concussion, Evan D. Anderson, Tanveer Talukdar, Grace Goodwin, Valentina Di Pietro, Kamal M. Yakoub, Christopher E. Zwilling, David Davies, Antonio Belli, Aron K. Barbey Aug 2023

Assessing Blood Oxygen Level–Dependent Signal Variability As A Biomarker Of Brain Injury In Sport-Related Concussion, Evan D. Anderson, Tanveer Talukdar, Grace Goodwin, Valentina Di Pietro, Kamal M. Yakoub, Christopher E. Zwilling, David Davies, Antonio Belli, Aron K. Barbey

Center for Brain, Biology, and Behavior: Faculty Publications

Mild traumatic brain injury is a complex neurological disorder of significant concern among athletes who play contact sports. Athletes who sustain sport-related concussion typically undergo physical examination and neurocognitive evaluation to determine injury severity and return-to-play status. However, traumatic disruption to neurometabolic processes can occur with minimal detectable anatomic pathology or neurocognitive alteration, increasing the risk that athletes may be cleared for return-to-play during a vulnerable period and receive a repetitive injury. This underscores the need for sensitive functional neuroimaging methods to detect altered cerebral physiology in concussed athletes. The present study compared the efficacy of Immediate Post-concussion Assessment and …


Interference Between Speaking And Computer Tasks In Younger And Older Adults, Paige Elise Asay Aug 2023

Interference Between Speaking And Computer Tasks In Younger And Older Adults, Paige Elise Asay

Theses and Dissertations

This study examined the effects of computer tasks on speech acoustic measures and the effects of speaking on computer task performance in 30 younger and 30 older adults. Participants completed a speech only task, two computer tasks, and simultaneous speaking and computer tasks. Stimulus sentences included the four corner vowels and two diphthongs embedded between voiceless consonants. Acoustic measures of speech included diphthong transition extent and rate as well as vowel space area (VSA) and vowel articulation index (VAI). A text formatting task included two levels of difficulty. A data entry task included sorting items from a shopping list into …


Taxonomic Revision And Phylogenetic Analysis Of The Philadelphicus Group In The Genus Proctacanthus (Insecta: Diptera: Asilidae), And Key To All Proctacanthus North Of Mexico, Teagan Marie Mulford Aug 2023

Taxonomic Revision And Phylogenetic Analysis Of The Philadelphicus Group In The Genus Proctacanthus (Insecta: Diptera: Asilidae), And Key To All Proctacanthus North Of Mexico, Teagan Marie Mulford

Theses and Dissertations

Proctacanthus (Macquart 1838), an elegant genus of robber flies within the Asilidae family, plays a significant ecological and economic role. However, the lack of a comprehensive taxonomic treatment hinders their identification and thus their use in evolutionary and behavioral research. This study focuses on the taxonomic revision of the Proctacanthus, identifying the features used in recognizing the philadelphicus Species Group and the rufiventris Species Group. By providing systematic and biological data, describing new species, and offering a key for identification, this research contributes to understanding the ecological significance and geographic distribution and history of Proctacanthus. This work will enhance future …


Feasibility Of Rna-Based Pathogen Detection In An Infant Formula Matrix, Gweneth Claire Gustafson Aug 2023

Feasibility Of Rna-Based Pathogen Detection In An Infant Formula Matrix, Gweneth Claire Gustafson

Theses and Dissertations

Background: The dairy processing industry is currently hindered by slow, antiquated testing for high-risk pathogens, including Listeria monocytogenes and Cronobacter sakazakii. Powder infant formula's low water activity and substantial fat content enhance the survival and thermotolerance of such foodborne pathogens. As DNA-based detection methods can produce false positives even after cell death, a more accurate approach is needed. The objective of this study is to evaluate the suitability of an RNA-based platform for the detection of pathogens in a dairy powder matrix. Materials and Methods: A unique phenol-chloroform extraction method was used to obtain total RNA from heat-killed and unheated …


Bridging The Gaps In Dgbi: The Mind Body Approach To Abdominal Pain, Nora Luck, Soroush Shahamatdar, Stephanie A. Eucker Aug 2023

Bridging The Gaps In Dgbi: The Mind Body Approach To Abdominal Pain, Nora Luck, Soroush Shahamatdar, Stephanie A. Eucker

URGENT Matters

No abstract provided.


Automated Processing Of Metabolomics Data For Population-Scale Studies, Ethan Stancliffe Aug 2023

Automated Processing Of Metabolomics Data For Population-Scale Studies, Ethan Stancliffe

Arts & Sciences Graduate Student Theses and Dissertations

The growth of untargeted metabolomic profiling technology has prompted the upstart of many large cohort studies. Metabolomics serves as an informative complement to other more established ‘omics (e.g., genomics, transcriptomics, proteomics). As a younger discipline, however, experimental and computational workflows are non-standardized and at times inadequate for large-scale studies. Two primary limitations in analysis of untargeted metabolomics data are 1) the poor performance and scalability of the algorithms applied to detect metabolite signals from the raw LC/MS data and 2) inefficient and arduous metabolite identification, which is the process of determining the biochemical structures that correspond to the detected LC/MS …


Surface Roughness And Surface Hardness Changes In Composite Resin Provisional Crown Before And After Brushing With Whitening Toothpaste, Dea S. Putri, Ika Andryas Aug 2023

Surface Roughness And Surface Hardness Changes In Composite Resin Provisional Crown Before And After Brushing With Whitening Toothpaste, Dea S. Putri, Ika Andryas

Journal of Dentomaxillofacial Science

Objective: To determine the surface roughness and surface hardness difference in composite resin provisional crown before and after brushing with whitening toothpaste.

Material and Methods: This was a pre- and post-test group design experimental study. In this study, the sample was a composite resin provisional crown based on bis-acryl. The number of samples in this study was 32 samples, 16 for the surface roughness test and the other 16 for the surface hardness test. Each sample was brushed using a V8-Brushing Machine Modified, then tested for surface roughness and hardness using a Profilometer and Vickers Hardness Tester.

Results: The paired …


Potential Of Nano Hydroxyapatite Synthesized From Blood Clam Shells As A Remineralizing Agent After In-Office Bleaching, Noor Hikmah, Maria Tanumihardja, Juni J. Nugroho, Nurhayaty Natsir, Nurlindah Hamrun, Syahruddin Kasim Aug 2023

Potential Of Nano Hydroxyapatite Synthesized From Blood Clam Shells As A Remineralizing Agent After In-Office Bleaching, Noor Hikmah, Maria Tanumihardja, Juni J. Nugroho, Nurhayaty Natsir, Nurlindah Hamrun, Syahruddin Kasim

Journal of Dentomaxillofacial Science

Introduction: The effect of bleaching on tooth structure is the loss of interprismatic substance which causes prism irregularities and changes in enamel morphology such as increased porosity and demineralization. This can be stopped by encouraging remineralization if the pH is neutralized and there are enough calcium and phosphate ions in the oral cavity. One agent that can be used to help the remineralization process is nano hydroxyapatite (nHA) which is a bioactive and biocompatible material for the natural mineral enamel. This study aims to determine change in the percentage of porosity, calcium, phosphate and hydroxyapatite synthesized from blood clam shells …


Osteocalcin Levels Evaluation Of Freeze-Dried Homologus Platelet-Rich Plasma In Periodontal Treatment, Niken Olivia, Kwartarini Murdiastuti Aug 2023

Osteocalcin Levels Evaluation Of Freeze-Dried Homologus Platelet-Rich Plasma In Periodontal Treatment, Niken Olivia, Kwartarini Murdiastuti

Journal of Dentomaxillofacial Science

Objective: The aim of this study was to evaluate enhanced osteocalcin levels by using freeze-dried homologous platelet-rich plasma (FD HPRP) in periodontal treatment to support the osteogenesis process.

Material and Methods: FD HPRP was made by HPRP from the blood bank, then freeze-drying and for sterilization, the γ-radiation process was carried out with doses of 20 and 25 kGy. The osteoblast (Cell line MG63) was cultured to confluent and then treated with FD HPRP 20 kGy, FD HPRP 25 kGy. Osteocalcin levels were tested using enzyme-linked immunosorbent assay (ELISA) on the 7th and 14th days. The data were analyzed using …


Rural Science Teachers Social Network Analysis Matrices, Rebecca L. Sansom, Tracy Poulsen Aug 2023

Rural Science Teachers Social Network Analysis Matrices, Rebecca L. Sansom, Tracy Poulsen

ScholarsArchive Data

These are the social network matrices for our study of rural science teachers. Each matrix is located on a separate tab on the spreadsheet.


Framing Complex Challenges, Joseph V. Sinfield, Romika R. Kotian Aug 2023

Framing Complex Challenges, Joseph V. Sinfield, Romika R. Kotian

Innovation Insight Series

Innovating to achieve impact at scale in ill-structured environments is a complex challenge, with numerous socio-techno-economic dimensions. Whether tailoring a product or service offering to meet the needs of a global customer base, forecasting the socio-economic implications of a new technology, or working to address a societal challenge in a low-to-middle income country, problems that encompass social, technical and/or economic uncertainty, significant variations in involved stakeholder characteristics, and even subtle differences across the focal environment, inevitably benefit from a holistic analysis that spans multiple levels of abstraction, encompasses a plurality of perspectives, and can be tailored to include contextual nuances. …


Publishing Inequality In Lgbtqia+ Research In Psychology: A Content Analysis, Mackenzie L. Fingerhut Aug 2023

Publishing Inequality In Lgbtqia+ Research In Psychology: A Content Analysis, Mackenzie L. Fingerhut

Student Theses

Despite the American Psychiatric Association’s removal of homosexuality from the Diagnostic and Statistical Manual of Mental Disorders in 1973 and ego-dystonic homosexuality in 1987, nonheteronormative sexual orientations remain stigmatized and underrepresented in scientific literature. To estimate the prevalence of LGBTQIA+ topics in popular psychological research, the author queried more than 20,000 articles from 1987 to 2022 in the two most cited journals in each of four major domains (cognitive, clinical, developmental and social). In addition, the author randomly queried 20% of all empirical articles published from 1987 to 2021 in the top eight empirical journals to understand how often sexuality …


Critical Engagements With Award Winning Picturebooks: My Journey In Creating A More Equitable Classroom Library, Carrie Elizabeth Crowe Aug 2023

Critical Engagements With Award Winning Picturebooks: My Journey In Creating A More Equitable Classroom Library, Carrie Elizabeth Crowe

Theses and Dissertations

Research consistently shows that students from historically marginalized populations have difficulty accessing texts that represent the realities of their lives. Concerned that such might be the case for my students, I conducted an inventory of my classroom library and sought out award-winning texts that could make my library more diverse and inclusive. I then analyzed these award-winning texts using Bishop's (1992) categories of multicultural literature in order to better understand the picturebooks' underlying messages and ideologies. My examinations showed that the majority of the texts fit into the same category (culturally specific), though I was able to identify award-winning texts …


Terahertz From Electrons, Electronics From Terahertz, Clayton D. Moss Aug 2023

Terahertz From Electrons, Electronics From Terahertz, Clayton D. Moss

Theses and Dissertations

Time-domain terahertz spectroscopy (THz-TDS) is a valuable technique for studying collective ultrafast phenomena. Several mechanisms exist for converting ultrashort optical laser pulses into coherent THz sources. Broadband THz pulses can be obtained from electron currents in air plasma, which requires combinations of different colors of light to be most effective. I report multi-color generation schemes of THz pulses that deliver coherent THz output. Experimental and theoretical work using the photocurrent model describe ways to use non-harmonic color combinations to utilize several sources of light available in a table-top laser setup. Additionally, THz-TDS is used to study a variety of ultrafast …


Interfraction Variability Of Breathing Amplitude Of Patients Undergoing Sbrt Lung Treatment And The Potential Impact On Dosimetry, Christian Padilla Gallegos Aug 2023

Interfraction Variability Of Breathing Amplitude Of Patients Undergoing Sbrt Lung Treatment And The Potential Impact On Dosimetry, Christian Padilla Gallegos

Masters Projects

Abstract

Introduction

The study investigated the consistency of free breathing planning margins for fractionated SBRT treatment in the lung. The study compared breathing motion from the average CT (AVE CT) scan to the Cone Beam Computed Tomography (CBCT) from each treatment session. Various breathing techniques were also discussed, including deep inspiration breath hold (DIBH), gated breathing, abdominal compression (AC), and free breathing (FB). Free-breathing may lead to overdosing on surrounding healthy tissue if significant changes in breathing amplitude occur. Abdominal compression or breath hold may reduce abnormal breathing movement if erratic breathing occurs. The study's aim was to ensure the …


Dosimetric Evaluation Of Left-Sided Chest Wall Vmat Treatment With And Without Jaw Tracking; Dose Comparison Of Left Anterior Descending Artery Versus Heart Mean Dose, Jacqueline J. Emus Aug 2023

Dosimetric Evaluation Of Left-Sided Chest Wall Vmat Treatment With And Without Jaw Tracking; Dose Comparison Of Left Anterior Descending Artery Versus Heart Mean Dose, Jacqueline J. Emus

Masters Projects

Radiation therapy has significantly improved breast cancer survival rates; however, it can still lead to long-term side effects, particularly affecting the heart. Left-side breast cancer patients face higher risks due to the proximity of the heart to the treatment area. To mitigate cardiac toxicity, various strategies, including jaw tracking and Volumetric Modulated Arc Therapy (VMAT), have been proposed. This study investigates the dosimetric impact of VMAT plans with and without jaw tracking on the left anterior descending artery (LAD) dose and heart mean dose in post-mastectomy breast cancer patients. Ten patients previously treated with VMAT were evaluated, and the results …


Prevalence And Factors Associated With Vaping Cannabidiol Among Us Adolescents, Hongying Daisy Dai, Roma Subramanian, Avina Mahroke, Ming Wang Aug 2023

Prevalence And Factors Associated With Vaping Cannabidiol Among Us Adolescents, Hongying Daisy Dai, Roma Subramanian, Avina Mahroke, Ming Wang

College of Journalism and Mass Communications: Faculty Publications

IMPORTANCE e-Cigarette use and vaping marijuana (cannabis) are popular among US adolescents. Cannabidiol (CBD) is a compound found in the cannabis plant that has recently increased in use.

OBJECTIVES To examine the prevalence of and factors associated with youths vaping CBD

DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study included a nationally representative sample of students from middle and high schools (typical age, 11-18 years) in the US from the 2022 National Youth Tobacco Survey, conducted from January to May 2022.

EXPOSURE Demographic characteristics, harm perception of tobacco use, and vaping behaviors.

MAIN OUTCOMES AND MEASURES The main outcomes were weighted …


Bothe '25 Investigates Treatment For Corneal Nerve Damage, Julia Perez Aug 2023

Bothe '25 Investigates Treatment For Corneal Nerve Damage, Julia Perez

News and Events (Discontinued Series)

No abstract provided.


Acute Pseudomembranous Candidiasis Accompanied With Oral Malignant Lesions In Hiv-Infected Patient: Case Report, Dian Angriany, Hendri Susanto, Adiastuti Endah, Bagus Soebadi Aug 2023

Acute Pseudomembranous Candidiasis Accompanied With Oral Malignant Lesions In Hiv-Infected Patient: Case Report, Dian Angriany, Hendri Susanto, Adiastuti Endah, Bagus Soebadi

Journal of Dentomaxillofacial Science

Objective: Oral candidiasis is the most opportunistic infection in HIV/AIDS patient. Neoplasms may also frequently be found in the oral cavity of HIV/AIDS patient and may indicate the progression of HIV infection. Case Report: A 56-year-old complaint of yellowish-white spots in oral cavity and swelling in the palate accompanied with shortness of breath and difficulty in eating and swallowing. Various medication was used to relieve the complaints but there were no improvements. He claimed a weight loss of 10 kg in last three months. Physically showed pale and weakness. Intraorally, diffuse pseudomembranous was found throughout the oral cavity to pharynx, …


Cytotoxicity Differences From Roots And Leaves Ethanol Extracts Of Annona Muricata Linn On Hsc-3, Naftalia M. Rizki, Moehamad O. Roeslan Aug 2023

Cytotoxicity Differences From Roots And Leaves Ethanol Extracts Of Annona Muricata Linn On Hsc-3, Naftalia M. Rizki, Moehamad O. Roeslan

Journal of Dentomaxillofacial Science

Objective: The aim of this study is to examine cytotoxicity differences between ethanol extract of A. muricata roots and leaves against HSC-3 cell line.

Material and Methods: HSC-3 cell lines were treated with ethanol extracts of A. muricata roots and leaves with 100, 30, 10, and 1 μg/mL concentrations for 24 hours. The percentage of cell viability was measured using MTT assay.

Results: The results showed significant differences (p <0.001) of treatments group compared to negative control. Ethanol extract of A. muricata roots showed the highest cytotoxicity against HSC-3 cell lines.

Conclusion: There is difference in cytotoxicity between ethanol extracts of A. muricata roots and leaves against HSC-3 cell lines where root extracts showed higher cytotoxicity.


Demineralized Freeze-Dried Bovine Bone Xenograft Enhance Osteoblast Viability And Proliferation For Jaw Regeneration Materials, Feni Istikharoh, Sinta C. Wardani, Ariyati R. Pratiwi, Hidayat Sujuti, Edi Mustamsir Aug 2023

Demineralized Freeze-Dried Bovine Bone Xenograft Enhance Osteoblast Viability And Proliferation For Jaw Regeneration Materials, Feni Istikharoh, Sinta C. Wardani, Ariyati R. Pratiwi, Hidayat Sujuti, Edi Mustamsir

Journal of Dentomaxillofacial Science

Objectives The aim of this study was to analyze the viability and proliferation properties of the DFDBBX in MC3T3-E1 cell line Material and Methods Bovine was milled to reach nano sizes of 100-200 nm. We used 2 mg/mL, 4 mg/mL and 8 mg/mL to incubate MC3T3-E1 cells in the following experiment. Immunocytochemistry methods were performed using a Live/Dead cell imaging kit to investigate the viability of MC3T3-E1. To investigate the proliferation of MC3T3-E1, ICC was performed using an anti-Ki67 antibody. Using a confocal laser scanning microscope (CLSM), the cells were observed at LSIH Brawijaya University. Statistical analysis was performed using …


Pilot Study Of A Screen-Free Week: Exploration Of Changes In Parent And Child Screen Time, Parent Well-Being And Attitudes, And Parent-Child Relationship Quality, Brandon T. Mcdaniel Phd, Sydney Rasmussen, Lauren Reining, Leesha Culp, Kacey Deverall Aug 2023

Pilot Study Of A Screen-Free Week: Exploration Of Changes In Parent And Child Screen Time, Parent Well-Being And Attitudes, And Parent-Child Relationship Quality, Brandon T. Mcdaniel Phd, Sydney Rasmussen, Lauren Reining, Leesha Culp, Kacey Deverall

Health Services and Informatics Research

Screen use is associated with a variety of potential impacts on child development, which has led to recommendations to regulate screen use. The current pilot study was conducted to explore the potential effects of implementing screen-free times (Screen-Free Week) on parent and child screen use, parent feelings and well-being, and parent-child interactions and relationships. Specifically, we evaluated the outcomes utilizing pre and postintervention self-report surveys with 24 parents (of a child age 5 years or younger). Overall, the screen-free week program decreased parent depressive symptoms, increased the parenting of child screen time and establishments of screen time limits, and decreased …


Platelet-Derived Exerkine Cxcl4/Platelet Factor 4 Rejuvenates Hippocampal Neurogenesis And Restores Cognitive Function In Aged Mice, Odette Leiter, David Brici, Stephen J Fletcher, Xuan Ling Hilary Yong, Jocelyn Widagdo, Nicholas Matigian, Adam B Schroer, Gregor Bieri, Daniel G Blackmore, Perry F Bartlett, Victor Anggono, Saul A Villeda, Tara L Walker Aug 2023

Platelet-Derived Exerkine Cxcl4/Platelet Factor 4 Rejuvenates Hippocampal Neurogenesis And Restores Cognitive Function In Aged Mice, Odette Leiter, David Brici, Stephen J Fletcher, Xuan Ling Hilary Yong, Jocelyn Widagdo, Nicholas Matigian, Adam B Schroer, Gregor Bieri, Daniel G Blackmore, Perry F Bartlett, Victor Anggono, Saul A Villeda, Tara L Walker

Faculty, Staff and Student Publications

The beneficial effects of physical activity on brain ageing are well recognised, with exerkines, factors that are secreted into the circulation in response to exercise, emerging as likely mediators of this response. However, the source and identity of these exerkines remain unclear. Here we provide evidence that an anti-geronic exerkine is secreted by platelets. We show that platelets are activated by exercise and are required for the exercise-induced increase in hippocampal precursor cell proliferation in aged mice. We also demonstrate that increasing the systemic levels of the platelet-derived exerkine CXCL4/platelet factor 4 (PF4) ameliorates age-related regenerative and cognitive impairments in …


Dynamics Of Anti-Influenza Mucosal Iga Over A Season In A Cohort Of Individuals Living Or Working In A Long-Term Care Facility, Matt D T Hitchings, Brooke A Borgert, Adam Shir, Bingyi Yang, Kyra H Grantz, Jacob Ball, Carlos A Moreno, Kenneth Rand, Parker A Small, Keith R Fowke, Derek A T Cummings Aug 2023

Dynamics Of Anti-Influenza Mucosal Iga Over A Season In A Cohort Of Individuals Living Or Working In A Long-Term Care Facility, Matt D T Hitchings, Brooke A Borgert, Adam Shir, Bingyi Yang, Kyra H Grantz, Jacob Ball, Carlos A Moreno, Kenneth Rand, Parker A Small, Keith R Fowke, Derek A T Cummings

Faculty, Staff and Student Publications

BACKGROUND: Serological surveys are used to ascertain influenza infection and immunity, but evidence for the utility of mucosal immunoglobulin A (IgA) as a correlate of infection or protection is limited.

METHODS: We performed influenza-like illness (ILI) surveillance on 220 individuals living or working in a retirement community in Gainesville, Florida from January to May 2018, and took pre- and postseason nasal samples of 11 individuals with polymerase chain reaction (PCR)-confirmed influenza infection and 60 randomly selected controls. Mucosal IgA against 10 strains of influenza was measured from nasal samples.

RESULTS: Overall, 28.2% and 11.3% of individuals experienced a 2-fold and …


Liposome-Based Carriers For Crispr Genome Editing, Xing Yin, Romain Harmancey, David D Mcpherson, Hyunggun Kim, Shao-Ling Huang Aug 2023

Liposome-Based Carriers For Crispr Genome Editing, Xing Yin, Romain Harmancey, David D Mcpherson, Hyunggun Kim, Shao-Ling Huang

Faculty, Staff and Student Publications

The CRISPR-based genome editing technology, known as clustered regularly interspaced short palindromic repeats (CRISPR), has sparked renewed interest in gene therapy. This interest is accompanied by the development of single-guide RNAs (sgRNAs), which enable the introduction of desired genetic modifications at the targeted site when used alongside the CRISPR components. However, the efficient delivery of CRISPR/Cas remains a challenge. Successful gene editing relies on the development of a delivery strategy that can effectively deliver the CRISPR cargo to the target site. To overcome this obstacle, researchers have extensively explored non-viral, viral, and physical methods for targeted delivery of CRISPR/Cas9 and …


Change Is The Only Constant: A Virtual Issue On Contemporary Catalysis, Shelley Minteer, Stephanie L. Brock, Géraldine Masson, Raymond E. Schaak Aug 2023

Change Is The Only Constant: A Virtual Issue On Contemporary Catalysis, Shelley Minteer, Stephanie L. Brock, Géraldine Masson, Raymond E. Schaak

Chemistry Faculty Research & Creative Works

No abstract provided.


Unraveling Hydrogen Atom Transfer Mechanisms With Voltammetry: Oxidative Formation And Reactivity Of Cobalt Hydride, Dylan G. Boucher, Andrew D. Pendergast, Xiangyu Wu, Zachary A. Nguyen, Rohit G. Jadhav, Song Lin, Henry S. White, Shelley D. Minteer Aug 2023

Unraveling Hydrogen Atom Transfer Mechanisms With Voltammetry: Oxidative Formation And Reactivity Of Cobalt Hydride, Dylan G. Boucher, Andrew D. Pendergast, Xiangyu Wu, Zachary A. Nguyen, Rohit G. Jadhav, Song Lin, Henry S. White, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

The utility of transition metal hydride catalyzed hydrogen atom transfer (MHAT) has been widely demonstrated in organic transformations such as alkene isomerization and hydro functionalization reactions. However, the highly reactive nature of the hydride and radical intermediates has hindered mechanistic insight into this pivotal reaction. Recent advances in electrochemical MHAT have opened up the possibility for new analytical approaches for mechanistic diagnosis. Here, we report a voltametric interrogation of Co-Based MHAT reactivity, describing in detail the oxidative formation and reactivity of the key Co-H intermediate and its reaction with aryl alkenes. Insights from cyclic voltammetry and finite element simulations help …