Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2023

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 9661 - 9690 of 35274

Full-Text Articles in Entire DC Network

Playing Darts Blindfolded: A Quasi-Experimental Study On Crnas And Srnas Knowledge On Pre-Procedural Ultrasound For Neuraxial Anesthesia, Drew Golden, Kristine Kim Aug 2023

Playing Darts Blindfolded: A Quasi-Experimental Study On Crnas And Srnas Knowledge On Pre-Procedural Ultrasound For Neuraxial Anesthesia, Drew Golden, Kristine Kim

College of Science and Health Theses and Dissertations

Pre-procedural ultrasound is an emerging technique among anesthesia providers to increase procedural efficiency and safety of neuraxial procedures on patients with increased technical difficulty. The use of pre-procedural ultrasound in neuraxial anesthesia among certified registered nurse anesthetists (CRNAs) and student registered nurse anesthetists (SRNAs) has not been previously described. This study examined the efficacy of an educational intervention on CRNAs’ and SRNAs’ knowledge and future intent to use pre-procedural ultrasound to identify lumbar intervertebral spaces. We utilized a pre-and post-test design with convenience sampling. This study demonstrated a statistically significant improvement in the participants’ knowledge in four out of seven …

Go to article

Gender Affirming Anesthesia: It’S More Than Pronouns, Matthew Klimesh, Angela Kurth Aug 2023

Gender Affirming Anesthesia: It’S More Than Pronouns, Matthew Klimesh, Angela Kurth

College of Science and Health Theses and Dissertations

Transgender individuals experience healthcare-related discrimination, resulting in significant disparities and negative health outcomes in comparison to the general population. Many CRNAs do not receive formal or adequate education before being expected to care for transgender patients that contributes to these negative health outcomes. To correct this problem, an educational intervention was created to improve anesthesia providers' knowledge of genderaffirming therapies and to survey anesthesia provider attitudes towards transgender patients and knowledge, beliefs, and preferences towards treating transgender patients. A sample of anesthesia providers was collected (n=27) that included SRNAs and CRNAs at varying levels of professional experience from diverse sociodemographic …

Go to article

Phytochemical Profile And Cervical Anticancer Activity Of An In Vitro N-Hexane Extract Of Kunto Dewo Fruit (Kigelia Pinnata) Peel And Flesh, Swarnasari Nurandita Isbandiputri, Surya Dwira, Diyah Kristanty Aug 2023

Phytochemical Profile And Cervical Anticancer Activity Of An In Vitro N-Hexane Extract Of Kunto Dewo Fruit (Kigelia Pinnata) Peel And Flesh, Swarnasari Nurandita Isbandiputri, Surya Dwira, Diyah Kristanty

Indonesian Journal of Medical Chemistry and Bioinformatics

Cervical cancer is the fourth highest cancer occurring and causes death in women. Therefore, adequate management is needed to prevent its development. Currently, the treatment has a variety of adverse side effects, so it needs alternative treatments that are supportive and with minimal side effects. One way is to use herbal plants, such as the Kunto Dewo (Kigelia pinnata) plant which is often used as traditional medicine. This plant has antimicrobial and cytotoxic effects on cancer cells. Knowing the phytochemical profile and in-vitro anticancer activity of the n-hexane extract of peel and flesh of Kunto Dewo (Kigelia pinnata) fruit against …

Go to article

Impact Analysis Of Gpt Technology Revolution On Fundamental Scientific Research, Mengge Sun, Tao Han, Yanpeng Wang, Yuxin Huang, Xiwen Liu Aug 2023

Impact Analysis Of Gpt Technology Revolution On Fundamental Scientific Research, Mengge Sun, Tao Han, Yanpeng Wang, Yuxin Huang, Xiwen Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The generative large model GPT represented by ChatGPT is developing rapidly, which has aroused extensive discussion in academic circle and the industry and has an incalculable impact on foundational scientific research development. The study first sorts out the development of the GPT technological revolution, and discusses the new changes brought about by this technology in scientific research. Then, based on the three aspects of application status, core principles and innovation subjects, the impact of the GPT technological revolution on basic scientific research and its development suggestions for China are discussed. The study believes that GPT technology can certainly play a …

Go to article

Current Conditions, Issues, And Suggestions For Ecological Protection And High-Quality Development In Loess Plateau, Bojie Fu, Yansui Liu, Zhi Cao, Zhuangzhuang Wang, Xutong Wu Aug 2023

Current Conditions, Issues, And Suggestions For Ecological Protection And High-Quality Development In Loess Plateau, Bojie Fu, Yansui Liu, Zhi Cao, Zhuangzhuang Wang, Xutong Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The ecological protection and high-quality development of the Yellow River Basin has been prioritized as a national strategy. The release and implementation of the Outline of the Yellow River Basin's Ecological Protection and High-quality Development Plan in 2021 have placed the Loess Plateau, located in the middle reach of the Yellow River, in a critical phase characterized by the need to sustain ecological restoration achievements while fostering socioeconomic progress. This study provides a comprehensive overview of the current conditions and issues related to ecological construction and socioeconomic development in the Loess Plateau. It proposes four specific suggestions focusing on improving …

Go to article

Research On China’S Marine Protected Areas Policy Based On Kunming-Montreal Global Biodiversity Framework 2030 Targets, Ke Duan, Xiulin Wang Aug 2023

Research On China’S Marine Protected Areas Policy Based On Kunming-Montreal Global Biodiversity Framework 2030 Targets, Ke Duan, Xiulin Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The Kunming-Montreal Global Biodiversity Framework adopted by the United Nations Convention on Biological Diversity (CBD) at the Conference of Parties (COP15) has set a series of targets, including protecting at least 30% of the oceans by 2030 worldwide. In China, how to build a marine ecological civilization in synergy with the targets has become an important issue. This study analyzes the necessity of accelerating the construction of marine protected areas in China from the perspectives of adapting to international trends, fulfilling the responsibilities of international conventions, safeguarding maritime rights and interests, and implementing the maritime power and strategy. The feasibility …

Go to article

In Silico Prediction Of Acute Chemical Toxicity Of Biocides In Marine Crustaceans Using Machine Learning, Rama Krishnan, Ian S. Howard, Sean Comber, Awadhesh N. Jha Aug 2023

In Silico Prediction Of Acute Chemical Toxicity Of Biocides In Marine Crustaceans Using Machine Learning, Rama Krishnan, Ian S. Howard, Sean Comber, Awadhesh N. Jha

School of Engineering, Computing and Mathematics

Biocides are a heterogeneous group of chemical substances intended to control the growth or kill undesired organisms. Due to their extensive use, they enter marine ecosystems via non-point sources and may pose a threat to ecologically important non-target organisms. Consequently, industries and regulatory agencies have recognized the ecotoxicological hazard potential of biocides. However, the prediction of biocide chemical toxicity on marine crustaceans has not been previously evaluated. This study aims to provide in silico models capable of classifying structurally diverse biocidal chemicals into different toxicity categories and predict acute chemical toxicity (LC50) in marine crustaceans using a set of calculated …

Go to article

Examining The Trend Of Literature On Classification Modelling: A Bibliometric Approach, Hashibah Hamid, Aidi Ahmi, Friday Z. Okwonu, Wan Azani Mustafa Aug 2023

Examining The Trend Of Literature On Classification Modelling: A Bibliometric Approach, Hashibah Hamid, Aidi Ahmi, Friday Z. Okwonu, Wan Azani Mustafa

Information Sciences Letters

This paper analyses and reports various types of published works related to classification or discriminant modelling. This paper adopted a bibliometric analysis based on the data obtained from the Scopus online database on 27th July 2019. Based on the ‘keywords’ search results, it yielded 2775 valid documents for further analysis. For data visualisation purposes, we employed VOSviewer. This paper reports the results using standard bibliometric indicators, particularly on the growth rate of publications, research productivity, analysis of the authors and citations. The outcomes revealed that there is an increased growth rate of classification literature over the years since 1968. A …

Go to article

It’S About Time: Tennessee’S Modernization Of Juvenile Sentencing And Where To Go From Here, Blake Lee, J.D. Aug 2023

It’S About Time: Tennessee’S Modernization Of Juvenile Sentencing And Where To Go From Here, Blake Lee, J.D.

Lincoln Memorial University Law Review Archive

Tennessee has long been considered the harshest in the nation regarding its treatment of minors convicted of first-degree murder. After the United States Supreme Court determined that automatic life sentences for juveniles violated the Eighth Amendment in Miller v. Alabama, many states began the process of reforming their sentencing statutes. Tennessee did not follow this trend, as the law on the books did not prescribe a “life sentence” to youthful homicide offenders. Rather, Tennessee’s sentencing statute automatically sentenced juveniles convicted of first-degree murder to a lengthy “term of years,” and as a result, did not fall within the reach …

Go to article

Threads, Buckets, And Impact: A Framework For Tool Accelerated Machine Learning Courses, Jonathan Adam Niemirowski Aug 2023

Threads, Buckets, And Impact: A Framework For Tool Accelerated Machine Learning Courses, Jonathan Adam Niemirowski

Doctoral Dissertations

Artificial intelligence and machine learning (ML) have exploded in use, accessibility, and awareness in the past few years, particularly with the release of ChatGPT in late 2022. Advances in end-user ML tools are accelerating the development of ML applications, lowering the technical barrier of entry for users outside of the computer science (CS) community. Access to ML education within STEM is mostly limited to upper-level computer science courses that have deep pre-requisite requirements or to introductory workshops that yield limited ML skills. Despite the critical need for ML education, there is a lack of guidance in instructional design for applied …

Go to article

Nh Agricultural Experiment Station’S New Create Grants Promote Multidisciplinary Science, Nicholas Gosling Aug 2023

Nh Agricultural Experiment Station’S New Create Grants Promote Multidisciplinary Science, Nicholas Gosling

UNH Today Archive

No abstract provided.

Go to article

Multiomic Investigations Into Lung Health And Disease, Sarah E Blutt, Cristian Coarfa, Josef Neu, Mohan Pammi Aug 2023

Multiomic Investigations Into Lung Health And Disease, Sarah E Blutt, Cristian Coarfa, Josef Neu, Mohan Pammi

Faculty, Staff and Students Publications

Diseases of the lung account for more than 5 million deaths worldwide and are a healthcare burden. Improving clinical outcomes, including mortality and quality of life, involves a holistic understanding of the disease, which can be provided by the integration of lung multi-omics data. An enhanced understanding of comprehensive multiomic datasets provides opportunities to leverage those datasets to inform the treatment and prevention of lung diseases by classifying severity, prognostication, and discovery of biomarkers. The main objective of this review is to summarize the use of multiomics investigations in lung disease, including multiomics integration and the use of machine learning …

Go to article

Chromophore Carbonyl Twisting In Fluorescent Biosensors Encodes Direct Readout Of Protein Conformations With Multicolor Switching, Malin J Allert, Shivesh Kumar, You Wang, Lorena S Beese, Homme W Hellinga Aug 2023

Chromophore Carbonyl Twisting In Fluorescent Biosensors Encodes Direct Readout Of Protein Conformations With Multicolor Switching, Malin J Allert, Shivesh Kumar, You Wang, Lorena S Beese, Homme W Hellinga

2020-Current year OA Pubs

Fluorescent labeling of proteins is a powerful tool for probing structure-function relationships with many biosensing applications. Structure-based rules for systematically designing fluorescent biosensors require understanding ligand-mediated fluorescent response mechanisms which can be challenging to establish. We installed thiol-reactive derivatives of the naphthalene-based fluorophore Prodan into bacterial periplasmic glucose-binding proteins. Glucose binding elicited paired color exchanges in the excited and ground states of these conjugates. X-ray structures and mutagenesis studies established that glucose-mediated color switching arises from steric interactions that couple protein conformational changes to twisting of the Prodan carbonyl relative to its naphthalene plane. Mutations of residues contacting the carbonyl …

Go to article

Ultrasound Assisted Comparative Study Of Fucolam And So-Dium Alginate And Impact On Their Physiochemical Proper-Ties Using Box-Behnken Design, Uday Bagale, Ammar Kadi, Artem Malinin, Varisha Anjum, Irina Potoroko Aug 2023

Ultrasound Assisted Comparative Study Of Fucolam And So-Dium Alginate And Impact On Their Physiochemical Proper-Ties Using Box-Behnken Design, Uday Bagale, Ammar Kadi, Artem Malinin, Varisha Anjum, Irina Potoroko

Karbala International Journal of Modern Science

The article discusses about the possibility of comparing the impact of ultrasonic treatment on fucolam and sodium algi-nate. The purpose was to study the effect of micronization on the sulfated heteropolysaccharide fucolam, analyzing its dispersed state and accessibility by reducing its molecular weight and increasing antioxidant activity. The optimization of the micronization process was carried out using the Box-Behnken Design (BBD) method, with a sonication time ranging from 15 to 45 min, power ranging from 50 to 100 W/cm2, and temperature between 30 °C and 40 °C. The fixed lower fucolam concentration was 0.1%. The results illustrated that sonochemical treatment …

Go to article

Deep Learning-Based Cad System For Predicting The Covid-19 X-Ray Images, Aqeel R. Talib, Hana’ M. Ali Aug 2023

Deep Learning-Based Cad System For Predicting The Covid-19 X-Ray Images, Aqeel R. Talib, Hana’ M. Ali

Karbala International Journal of Modern Science

According to World Health Organization data, Coronavirus (COVID-19) has infected about 660, 378, 145 patients around the world. It is nonetheless difficult for physicians to detect COVID-19 infections out of CT or X-ray radiographs. Thus, several computer-aided diagnosis (CAD) systems based on deep learning and radiographs were developed to detect COVID-19 infections. However, the majority of approaches considered small datasets, which is ineligible to provide diverse COVID-19 radiographs. This work utilizes a massive number of X-ray radiographs, and compared standard CNN, DenseNet-121, and GoogLeNet for isolating COVID-19 infections out from normal and other pneumonia radiographs. The dataset in this work …

Go to article

Prosecutorial Actus Reus: Appellate Review Of Prosecutorial Misconduct And The Diminishment Of Responsibility, Elizabeth Griffiths, Heather L. Scheuerman, Sandy Xie Aug 2023

Prosecutorial Actus Reus: Appellate Review Of Prosecutorial Misconduct And The Diminishment Of Responsibility, Elizabeth Griffiths, Heather L. Scheuerman, Sandy Xie

International Journal on Responsibility

The socio-historical concept of criminal responsibility links the action (actus reus) and mental state (mens rea), or intention, of the actor (i.e., the defendant) to determine legal and moral liability for his or her behavior and to apportion punishment. When the actor responsible for immoral conduct is the prosecutor in pursuit of a conviction, the courts respond very differently. More specifically, because prosecutors are presumed to be moral and ethical system actors, assumptions about their good character likely influence the ways in which they are held to account. This study explores the content and arguments made …

Go to article

Summer 2023 Commencement - The University Of Texas Of The Permian Basin, The University Of Texas Permian Basin Aug 2023

Summer 2023 Commencement - The University Of Texas Of The Permian Basin, The University Of Texas Permian Basin

UTPB Commencement Programs

Summer 2023 Commencement - August 18, 2023

Go to article

"The Trees Act Not As Individuals"--Learning To See The Whole Picture In Biology Education And Remote Sensing Research, Rebeka A.F. Greenall Aug 2023

"The Trees Act Not As Individuals"--Learning To See The Whole Picture In Biology Education And Remote Sensing Research, Rebeka A.F. Greenall

Theses and Dissertations

To increase equity and inclusion for underserved and excluded Indigenous students, we must make efforts to mitigate the unique barriers they face. As their knowledge systems have been historically excluded and erased in Western science, we begin by reviewing the literature on the inclusion of Traditional Ecological Knowledge (TEK) in biology education and describe best practices. Next, to better understand how Native Hawaiian and other Pacific Islander (NHPI) students integrate into the scientific community, we used Social Influence Theory as a framework to measure NHPI student science identity, self-efficacy, alignment with science values, and belonging. We also investigated how students …

Go to article

Exome-Based New Allele-Specific Pcr Markers And Transferability For Sodicity Tolerance In Bread Wheat (Triticum Aestivum L.), Roopali Bhoite, Rosemary Smith, Urmil Bansal, Mirza Dowla, Harbans Bariana, Darshan L. Sharma Aug 2023

Exome-Based New Allele-Specific Pcr Markers And Transferability For Sodicity Tolerance In Bread Wheat (Triticum Aestivum L.), Roopali Bhoite, Rosemary Smith, Urmil Bansal, Mirza Dowla, Harbans Bariana, Darshan L. Sharma

Grain and Other Field Crops Research Articles

Targeted exome-based genotype by sequencing (t-GBS), a sequencing technology that tags SNPs and haplotypes in gene-rich regions was used in previous genome-wide association studies (GWAS) for sodicity tolerance in bread wheat. Thirty-nine novel SNPs including 18 haplotypes for yield and yield-components were identified. The present study aimed at developing SNP-derived markers by precisely locating new SNPs on ~180 bp allelic sequence of t-GBS, marker validation, and SNP functional characterization based on its exonic location. We identified unknown locations of significant SNPs/haplotypes by aligning allelic sequences on to IWGSC RefSeqv1.0 on respective chromosomes. Eighteen out of the target 39 SNP locations …

Go to article

Comparative Proteomic Analysis Of Exosomes Derived From Endothelial Cells And Schwann Cells, Lei Wang, Xuerong Lu, Michael Chopp, Chao Li, Yi Zhang, Alexandra Szalad, Xian Shuang Liu, Zhenggang Zhang Aug 2023

Comparative Proteomic Analysis Of Exosomes Derived From Endothelial Cells And Schwann Cells, Lei Wang, Xuerong Lu, Michael Chopp, Chao Li, Yi Zhang, Alexandra Szalad, Xian Shuang Liu, Zhenggang Zhang

Neurology Articles

Exosomes derived from endothelial cells and Schwann cells have been employed as novel treatments of neurological diseases, including peripheral neuropathy. Exosomal cargo plays a critical role in mediating recipient cell function. In this study, we thus performed a comprehensive proteomic analysis of exosomes derived from healthy mouse dermal microvascular endothelial cells (EC-Exo) and healthy mouse Schwann cells (SC-Exo). We detected 1,817and 1,579 proteins in EC-Exo and SC-Exo, respectively. Among them, 1506 proteins were present in both EC-Exo and SC-Exo, while 311 and 73 proteins were detected only in EC-Exo and SC-Exo, respectively. Bioinformatic analysis revealed that EC-Exo enriched proteins were …

Go to article

Increased Sirt3 Combined With Parp Inhibition Rescues Motor Function Of Sbma Mice., David R Garcia Castro, Joseph R Mazuk, Erin M Heine, Daniel Simpson, R Seth Pinches, Caroline Lozzi, Kathryn Hoffman, Phillip Morrin, Dylan Mathis, Maria V Lebedev, Elyse Nissley, Kang Hoo Han, Tyler Farmer, Diane E Merry, Qiang Tong, Maria Pennuto, Heather L. Montie Aug 2023

Increased Sirt3 Combined With Parp Inhibition Rescues Motor Function Of Sbma Mice., David R Garcia Castro, Joseph R Mazuk, Erin M Heine, Daniel Simpson, R Seth Pinches, Caroline Lozzi, Kathryn Hoffman, Phillip Morrin, Dylan Mathis, Maria V Lebedev, Elyse Nissley, Kang Hoo Han, Tyler Farmer, Diane E Merry, Qiang Tong, Maria Pennuto, Heather L. Montie

PCOM Scholarly Works

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease with substantial mitochondrial and metabolic dysfunctions. SBMA is caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Activating or increasing the NAD+-dependent deacetylase, SIRT3, reduced oxidative stress and death of cells modeling SBMA. However, increasing diminished SIRT3 in AR100Q mice failed to reduce acetylation of the SIRT3 target/antioxidant, SOD2, and had no effect on increased total acetylated peptides in quadriceps. Yet, overexpressing SIRT3 resulted in a trend of motor recovery, and corrected TCA cycle activity by decreasing acetylation of SIRT3 target proteins. We sought to boost blunted …

Go to article

Fantasy Escapism: Using Role-Playing Games To Explore Mental Health And Gender Identity, Aidan Cipolla Aug 2023

Fantasy Escapism: Using Role-Playing Games To Explore Mental Health And Gender Identity, Aidan Cipolla

English and Creative Writing Summer Fellows

This project analyzes how escapism through the use of role-playing games can be used as a coping mechanism for those struggling with a variety of topics, including gender dysphoria and mental health issues. The project takes an ethnographic approach to data gathering, consisting of interviews with a small group of Dungeons and Dragons / video game players, and personal anecdotes regarding the author’s experience with escapism.

Go to article

Illegal Shooting Is Now A Leading Cause Of Death Of Birds Along Power Lines In The Western Usa, Eve C. Thomason, Natalie J. S. Turley, James R. Belthoff, Tara J. Conkling, Todd E. Katzner Aug 2023

Illegal Shooting Is Now A Leading Cause Of Death Of Birds Along Power Lines In The Western Usa, Eve C. Thomason, Natalie J. S. Turley, James R. Belthoff, Tara J. Conkling, Todd E. Katzner

Biology Faculty Publications and Presentations

Human actions, both legal and illegal, affect wildlife in many ways. Inaccurate diagnosis of cause of death undermines law enforcement, management, threat assessment, and mitigation. We found 410 dead birds collected along 196 km of power lines in four western USA states during 2019–2022. We necropsied these carcasses to test conventional wisdom suggesting that electrocution is the leading cause of death of birds at electrical infrastructure. Of 175 birds with a known cause of death, 66% died from gunshot. Both raptors and corvids were more likely to die from gunshot than from other causes, along both transmission and distribution lines. …

Go to article

A Thesis On The Human Genetic Basis Of Severe Pneumococcal Infection In Papua New Guinea, Emma Catherine Walker Aug 2023

A Thesis On The Human Genetic Basis Of Severe Pneumococcal Infection In Papua New Guinea, Emma Catherine Walker

Arts & Sciences Graduate Student Theses and Dissertations

Pneumonia remains a major cause of childhood mortality, especially in under-resourced communities. The profound morbidity of pediatric pneumonia in Papua New Guinea (PNG) compels innovative approaches to ameliorate disease. While the high incidence of pneumonia has been ascribed to environmental factors, we here identify a heritable allele increasing risk of severe pneumonia. In a pilot study, whole exome sequencing reveals a single nucleotide variant (SNV) in coenzyme Q6 (COQ6), a mitochondrial enzyme essential for ubiquinone biosynthesis. Significant association of SNV homozygosity with pneumonia replicates in an independently recruited cohort (p=0.036). Mice homozygous for the murine variant exhibit increased mortality after …

Go to article

Investigating The Effects Of Opioid Exposure And Withdrawal On Endogenous Opioid Peptide Systems, Neuroimmune Interactions, And Striatal Neuron Activity, Marwa Mikati Aug 2023

Investigating The Effects Of Opioid Exposure And Withdrawal On Endogenous Opioid Peptide Systems, Neuroimmune Interactions, And Striatal Neuron Activity, Marwa Mikati

Arts & Sciences Graduate Student Theses and Dissertations

Endogenous opioid peptides and their receptors perform critical roles in reward, aversion, and drug exposure processes. Both the peptides and the receptors perform distinct roles in modulating behavior depending on the brain region and stimulus in question. It has long been a challenge to study opioid peptides specifically because they are structurally similar to each other and occur at very low concentrations. Therefore, understanding their roles in stress, drug exposure, and drug withdrawal has presented difficulty for researchers over the years. To address this difficulty, I helped develop a method for the detection of enkephalins, a class of opioid peptides, …

Go to article

The Role Of Curcumin On Apoptosis And Nlrp3 Inflammasome-Dependent Pyroptosis On Colorectal Cancer In Vitro, Zeynep Dal, Başak Aru Aug 2023

The Role Of Curcumin On Apoptosis And Nlrp3 Inflammasome-Dependent Pyroptosis On Colorectal Cancer In Vitro, Zeynep Dal, Başak Aru

Turkish Journal of Medical Sciences

Background/aim: Colorectal cancer (CRC) is one of the most common cancers worldwide. Many factors such as stress, lifestyle, and dietary habits are known to play a role in the initiation and progression of the disease. Herbal therapeutic agents including curcumin can hold a great potential against cancer treatment; however, their efficacy on CRC is still under investigation. Herein, we evaluated the anticancer mechanism of curcumin on four different CRC cell lines. Materials and methods: Cells were treated with curcumin for 24, 48 and 72 h, and IC50 doses for each cell line were calculated. Mechanistic studies were conducted with the …

Go to article

Effects Of Thymoquinone And Memantine Alone And In Combination On Memory And Hippocampal Morphology In Rats With Streptozotocin-Induced Alzheimer's Disease, Şeyma Özsoy, Zi̇ya Çakir, Eli̇f Akçay, Fi̇kret Gevrek Aug 2023

Effects Of Thymoquinone And Memantine Alone And In Combination On Memory And Hippocampal Morphology In Rats With Streptozotocin-Induced Alzheimer's Disease, Şeyma Özsoy, Zi̇ya Çakir, Eli̇f Akçay, Fi̇kret Gevrek

Turkish Journal of Medical Sciences

Background/aim: Alzheimer's disease (AD) is a progressive neurodegenerative disease. Thymoquinone (TQ) has broad biological functions, including antiinflammatory, antioxidant, neuroprotective properties. Memantine (MEM) is indicated for the symptomatic treatment of moderate to severe AD. We aimed to evaluate the effect of TQ alone or in combination with MEM on memory and hippocampal morphology in an STZ-induced rat AD model. Materials and methods: Thirty male rats were included in this study. The AD model was created by giving ICV STZ. The rats were divided into 5 groups (n = 6 each). Group 1 (control group): The rats received only ICV-STZ 3 mg/kg …

Go to article

Radioprotective Effects Of Melatonin And Thymoquinone On Liver, Parotid Gland, Brain, And Testis Of Rats Exposed To Total Body Irradiation, Mehmet Koç, Çi̇ğdem Damla Deni̇z, Mehmet Aki̇f Eryilmaz, Yilmaz Tezcan, Mehmet Gürbi̇lek Aug 2023

Radioprotective Effects Of Melatonin And Thymoquinone On Liver, Parotid Gland, Brain, And Testis Of Rats Exposed To Total Body Irradiation, Mehmet Koç, Çi̇ğdem Damla Deni̇z, Mehmet Aki̇f Eryilmaz, Yilmaz Tezcan, Mehmet Gürbi̇lek

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate thymoquinone (TQ), and melatonin's radioprotective effects on liver, parotid gland, brain, and testis of rats which were exposed to total body irradiation (IR). Materials and methods: Thirty adult Wistar rats were randomly divided into four groups that are Group 1 (control group): total body IR only, Group 2: IR-Melatonin (10 mg/kg), Group 3: IR-TQ (10 mg/kg), and Group 4 (sham group): nothing. Total body IR dose was 6 Gy. Tissue samples were taken 90 min after IR. The measurements of malondialdehyde (MDA), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) were performed in all groups. …

Go to article

Survival Outcomes Of Patients With Oligometastatic Non-Small Cell Lung Cancer Who Were Treated With Radical Therapy: A Multicenter Analysis, Özgür Açikgöz, Ahmet Bi̇li̇ci̇, Deni̇z Tataroğlu Özyükseler, Sabi̇n Göktaş Aydin, Fati̇h Selçukbi̇ri̇ci̇k, Rashad Rzazade, Ömer Fati̇h Ölmez, Hale Başak Çağlar Aug 2023

Survival Outcomes Of Patients With Oligometastatic Non-Small Cell Lung Cancer Who Were Treated With Radical Therapy: A Multicenter Analysis, Özgür Açikgöz, Ahmet Bi̇li̇ci̇, Deni̇z Tataroğlu Özyükseler, Sabi̇n Göktaş Aydin, Fati̇h Selçukbi̇ri̇ci̇k, Rashad Rzazade, Ömer Fati̇h Ölmez, Hale Başak Çağlar

Turkish Journal of Medical Sciences

Background/aim: Oligometastatic disease for nonsmall cell lung cancer (NSCLC) patients is generally thought to represent a better prognosis with a quieter biology, limited number of disease sites and long-term disease control. In this study, we aimed to determine the efficacy of radical treatment options for patients with oligometastatic NSCLC. Materials and methods: This retrospective trial included totally 134 patients with oligometastatic NSCLC. The presence of oncodriver mutation, tumor stages and nodal status, the number of metastases and involved metastatic site, treatment of primary tumor and oligometastasis, response rate, overall survival (OS) and progression-free survival (PFS) were evaluated. Results: Of 134 …

Go to article

The History Of Forensic-Science Evidence In Criminal Trials And The Role Of Early “Success” In Establishing Its Putative Reliability, Carrie Leonetti Aug 2023

The History Of Forensic-Science Evidence In Criminal Trials And The Role Of Early “Success” In Establishing Its Putative Reliability, Carrie Leonetti

St. Mary's Law Journal

This Article posits the history of forensic-science evidence plays a significant role in the unquestioning manner of its modern acceptance. It traces early high-profile forensic science “successes” and the public reactions to them. It argues the public perception of the “advances” of forensic science continues to play a role in the lack of scrutiny given to these disciplines in admissibility decisions today. It concludes, when it comes to forensic science, history should play a different role by serving as a critical warning rather than a congratulatory buttress.

Go to article

First Prev Next Last