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2023

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Premenstrual Syndrome Levels And Eating Attitudes Among University Students, Ceyda Bahadur, Dilara Ergen, Nesibe Yildiz, Eda Dokumacioglu Aug 2023

Premenstrual Syndrome Levels And Eating Attitudes Among University Students, Ceyda Bahadur, Dilara Ergen, Nesibe Yildiz, Eda Dokumacioglu

Makara Journal of Health Research

Background: Premenstrual syndrome (PMS) is the combination of physical, behavioral, and psychological symptoms that characterize the week leading up to menstruation, and it can last for a few days. This study aimed to investigate irregular PMS, eating attitude behavior, and body mass index values among university students.

Methods: The study sample consisted of 140 Artvin Coruh University students studying Nutrition and Dietetics. The study includes questions from three separate sections. The first section contains a sociodemographic characteristic form, the second section consists of the Premenstrual Syndrome Scale (PMSS), and the third section includes the 26-item Eating Attitude Test …


Relationship Between Plasma Fluoride Levels, Glutathione Peroxidase Activity, Hemoglobin, And Abortion In Rural And Urban Pregnant Women From Settat (Morocco), Lalla Asmaa Katir Masnaoui, Abdellatif Rahim, Habiba Bouchab, Bouchra El Amiri, Boubker Nasser, Essamadi Abdel Khalid Aug 2023

Relationship Between Plasma Fluoride Levels, Glutathione Peroxidase Activity, Hemoglobin, And Abortion In Rural And Urban Pregnant Women From Settat (Morocco), Lalla Asmaa Katir Masnaoui, Abdellatif Rahim, Habiba Bouchab, Bouchra El Amiri, Boubker Nasser, Essamadi Abdel Khalid

Makara Journal of Health Research

Background: This study aimed to investigate the relationship between plasma fluoride and hemoglobin levels, glutathione peroxidase (GPx) activity, and abortion among rural and urban pregnant women from Settat province (Morocco).

Methods: Blood samples were collected from rural pregnant women who had not undergone abortion (N = 224), rural pregnant women who had an abortion (N = 38), urban pregnant women who had not undergone abortion (N = 163), and urban pregnant women who had an abortion (N = 14).

Results: The highest (p < 0.01) plasma fluoride levels and the lowest (p < 0.01) GPx activity were observed in rural pregnant women. In all participants, plasma fluoride levels were significantly higher (p < 0.001), and the GPx activity was significantly (p < 0.001) lower in pregnant women who had an abortion compared with those who did not undergo such process. No significant difference was observed between the hemoglobin levels of all participants. Furthermore, abortion was positively correlated with plasma fluoride levels (p < 0.001) and negatively correlated with GPx activity (p < 0.001) in rural participants.

Conclusions: Rural pregnant women had higher plasma …


Related Factors With Self-Management Behaviors Among Patients With Predialysis Chronic Kidney Disease: A Multicenter Study In Myanmar, Yoon Zarchi Wint, Jiraporn Lininger, Sirirat Leelacharas Aug 2023

Related Factors With Self-Management Behaviors Among Patients With Predialysis Chronic Kidney Disease: A Multicenter Study In Myanmar, Yoon Zarchi Wint, Jiraporn Lininger, Sirirat Leelacharas

Makara Journal of Health Research

Background: Self-management behavior is key to managing patients with predialysis chronic kidney disease (CKD) and is effective in slowing disease progression in impoverished Burmese patients with CKD. This study aimed to outline the association of personal and environmental factors with the self-management behaviors of people with predialysis CKD.

Methods: Using convenience sampling, this cross-sectional study included 84 individuals with predialysis CKD from two private hospitals in Myanmar. The interviewer-administered questionnaire included demographic information, the Health Literacy Short Form-12, the CKD knowledge questionnaire, the self-efficacy questionnaire, the Multidimensional Scale of Perceived Social Support, and the self-management behavior questionnaire. This …


Cross-Cultural Adaptation And Psychometric Properties Of The Arabic Version Of The Academic Nurse Self-Efficacy Scale, Junel Bryan Arre Bajet, Jonas Preposi Cruz, Ejercito Mangawa Balay-Odao, Jennifer Mesde, Nahed Alquwez, Khalaf Alotaibi, Sheerween Cacanando Aug 2023

Cross-Cultural Adaptation And Psychometric Properties Of The Arabic Version Of The Academic Nurse Self-Efficacy Scale, Junel Bryan Arre Bajet, Jonas Preposi Cruz, Ejercito Mangawa Balay-Odao, Jennifer Mesde, Nahed Alquwez, Khalaf Alotaibi, Sheerween Cacanando

Makara Journal of Health Research

Background: Students’ academic self-efficacy is greatly associated with their academic performance. An effective instrument is needed to assess academic self-efficacy in the Saudi context. This study assessed the psychometric properties of the Academic Nurse Self-Efficacy Scale-Arabic version (ANSE-A) given to student nurses and the associations between the students’ demographics and overall ANSE-A scores.

Methods: Quantitative and descriptive methods were applied. The study was conducted from January to July 2022 at Shaqra University with 200 nursing students as the convenience sample. For content validity, the item-level content and scale-level content validity indices were utilized following the averaging method. We …


Risk Factors Associated With Occupational Stress Among Malaysian Construction Professionals, Nur Syafiqah Fauzan, Nur Alia Farahanin Mohd Tajuddin, Neroshini Thanarejee, Dayana Hazwani Mohd Suadi Nata, Ezrin Hani Sukadarin, Mirta Widia Aug 2023

Risk Factors Associated With Occupational Stress Among Malaysian Construction Professionals, Nur Syafiqah Fauzan, Nur Alia Farahanin Mohd Tajuddin, Neroshini Thanarejee, Dayana Hazwani Mohd Suadi Nata, Ezrin Hani Sukadarin, Mirta Widia

Makara Journal of Health Research

Background: Construction industries that focus on project-based nature, pressure, and long hours may lead to job-related stress among workers. In many emerging nations, robust economic growth plans generate occupational depression, anxiety, and stress among construction industry personnel. This study aims to determine the relationship between these items and the risk factors (demographic) among Malaysian construction professionals.

Methods: A cross-sectional study was carried out among 173 Malaysian construction professionals. A DASS-21 questionnaire is used to survey eligible respondents.

Results: Findings show that construction professionals have a high level of stress (54.9%), anxiety (48.5%), and depression (37%). Gender is …


Association Between Rs2787094 Genetic Variants In Adam33 Gene And Asthma In Indonesian Population: Preliminary Study, Kencono Viyati, Kinasih Prayuni, Yenni Zulhamidah, Intan Razari, Rika Yuliwulandari Aug 2023

Association Between Rs2787094 Genetic Variants In Adam33 Gene And Asthma In Indonesian Population: Preliminary Study, Kencono Viyati, Kinasih Prayuni, Yenni Zulhamidah, Intan Razari, Rika Yuliwulandari

Makara Journal of Health Research

Background: Asthma is a multifactorial disease that encompasses a multitude of genetic and environmental factors. One such factor is the disintegrin and metalloprotein-33 (ADAM33) gene, which is correlated with asthma and bronchial hyperresponsiveness. Previous studies conducted on Asian populations have reported a significant association between rs2787094 polymorphism in the ADAM33 gene and asthma.

Methods: Our study involved 153 Indonesian participants. TaqMan genotyping assay was used to analyze rs2787094 polymorphism in the ADAM33 gene.

Results: No significant association was detected between the allele and genotype frequencies of rs2787094 and asthma in the case and control subjects (p …


The Biocompatibility Of A Ginger-Containing Herbal Toothpaste On Developing Zebrafish Embryos, Simge Meseli, Unsal Veli Ustundag, Perihan Seda Ates, Ismail Unal, Ebru Isik Alturfan, Dilek Tağtekin, Funda Yanikoglu Aug 2023

The Biocompatibility Of A Ginger-Containing Herbal Toothpaste On Developing Zebrafish Embryos, Simge Meseli, Unsal Veli Ustundag, Perihan Seda Ates, Ismail Unal, Ebru Isik Alturfan, Dilek Tağtekin, Funda Yanikoglu

Journal of Dentistry Indonesia

The biocompatibility of toothpaste in an oral cavity should be approved by clinical trials. Nowadays, herbal toothpaste is increasing in popularity due to its natural ingredients. Being genetically similar to humans, zebrafish are used in potential toxicity testing. The zebrafish embryotoxicity test is a fast and straightforward method to study chemical toxicity during embryogenesis.

Objective: This study aimed to evaluate if there was any biocompatibility of the toothpaste on zebrafish embryos.

Methods: Adult AB strain zebrafish were used according to Institutional Animal Care and Use Committee protocols. Normally dividing, spherical embryos were exposed to herbal toothpaste with ginger (Gumgumix, Turkey) …


Oral Leukoplakia: Diagnosis And Management Revisited, Isaäc Van Der Waal Aug 2023

Oral Leukoplakia: Diagnosis And Management Revisited, Isaäc Van Der Waal

Journal of Dentistry Indonesia

The definition of oral leukoplakia has not much changed during the past five decades and is still a definition by exclusion of ‘known’ lesions. Therefore, a diagnosis of leukoplakia is not always a straightforward one for the clinicians and, to some extent, also for the pathologists. The traditional clinical classification in homogeneous and nonhomogeneous leukoplakia may just be simplified into leukoplakia (thin and thick/verrucous) and erythroleukoplakia. In spite of numerous reported predictive molecular and genetic parameters of malignant transformation, the presence and grade of epithelial dysplasia as assessed by histopathological examination is still the most important one. Of the various …


Comparison Of Two Different Intraoral Scanners For Determination Of Caries Related Volume Loss In Caries Removal, Merve Şeker, Elif Alkan, Dilek Tağtekin, Bora Korkut, Funda Yanıkoğlu Aug 2023

Comparison Of Two Different Intraoral Scanners For Determination Of Caries Related Volume Loss In Caries Removal, Merve Şeker, Elif Alkan, Dilek Tağtekin, Bora Korkut, Funda Yanıkoğlu

Journal of Dentistry Indonesia

Objective: The study aimed to compare cavity volume data obtained with two different intraoral scanners. Methods: One hundred extracted molar teeth were divided into groups according to ICDAS-II classification, and scanned with Cerec Omnicam (Dentsply Sirona) and iTero Element Flex (Align Technology). The caries-infected tissues were removed regarding either minimally invasive or conventional cavity principles. Samples were scanned again and volumetric data were assessed by Meshmixer 3.5 (Autodesk) 3D modeling software. Statistical evaluations were performed with Mann Whitney U test and Spearman’s Correlation test. The significance level was α=0.05. Results: Although there was a significant difference between obtained …


Salivary Changes In Patients Hospitalized For Complications Of Hiv Infection/Aids: A Study Using Inductively Coupled Plasma Optical Emission Spectrometry, Vanessa Cavassin Klamas, Mateus Anhaia Ventura, Loana Mara Baika, Adryano Arana Kamei, Jhonatan Yukio Naka, Cassiano Lima Chaiben, Marco Tadeu Grassi, Antonio Adilson Soares De Lima Aug 2023

Salivary Changes In Patients Hospitalized For Complications Of Hiv Infection/Aids: A Study Using Inductively Coupled Plasma Optical Emission Spectrometry, Vanessa Cavassin Klamas, Mateus Anhaia Ventura, Loana Mara Baika, Adryano Arana Kamei, Jhonatan Yukio Naka, Cassiano Lima Chaiben, Marco Tadeu Grassi, Antonio Adilson Soares De Lima

Journal of Dentistry Indonesia

Objective: The aim of this study was to analyze the salivary flow and levels of major salivary ions of HIV-infected individuals. Methods: One hundred and two participants (18 - 74 years of age) were divided into two groups (51 HIV - infected patients and 51 controls) and had a saliva sample collected. Salivary flow rate was measured gravimetrically. Levels of salivary sodium, potassium, magnesium, calcium and phosphorus were analyzed by inductively coupled plasma optical emission spectrometry (ICP-OES). Results: The mean salivary flow of subjects with HIV infection was significantly higher when compared to controls (Case group = …


Perceived Stress, Severity Of Xerostomia, And Periodontal Status In Undergraduate Dental Students, Engku Ahmad Muzhaffar, Zurairah Berahim, Norsila Abdul Wahab, Norkhafizah Saddki Aug 2023

Perceived Stress, Severity Of Xerostomia, And Periodontal Status In Undergraduate Dental Students, Engku Ahmad Muzhaffar, Zurairah Berahim, Norsila Abdul Wahab, Norkhafizah Saddki

Journal of Dentistry Indonesia

Dentistry is a highly stressful program; stress is associated with xerostomia and periodontal disease.

Objective: This study aims to investigate the association of perceived stress, severity of xerostomia, and periodontal status in dental students.

Methods: This was a two-phase cross-sectional study of 245 Universiti Sains Malaysia (USM) undergraduate dental students. Phase 1 involved administration of the Perceived Stress Scale (PSS-10) and Summated Xerostomia Inventory (SXI). In phase 2, the Community Periodontal Index (CPI) was performed on 150 students to determine their periodontal status.

Results: Mean PSS-10 and SXI scores were 19.6 (SD 5.47) and 7.9 (SD 2.04), respectively. …


How To Manage Fan’S C Shape Canals Along With S Shape Morphology In Indian Population: A Case Series And Narrative Review, A Lavanya, Rajendra Kumar Tewari Aug 2023

How To Manage Fan’S C Shape Canals Along With S Shape Morphology In Indian Population: A Case Series And Narrative Review, A Lavanya, Rajendra Kumar Tewari

Journal of Dentistry Indonesia

The C-shaped root canals offer greater negotiation, debridement, and obturation difficulty as they present with intercommunications, lateral canals, and reduced dentin thickness.

Objective: This case series elaborates on the recognition that these varying configurations is important to enhance adequate cleaning, shaping, and sealing of the root canal.

Case Reports: On clinical examination, all the teeth showed caries were nonresponsive to sensibility tests and toother diagnostic tests, suggestive of pulp necrosis with apical periodontitis. Conventional root canal treatment with different techniques and obturation systems have been used. This case series presents the successful management of various C-shaped configurations classified by Fan …


The Effects Of Boric Acid On The Water Solubility Of Glass Ionomer Cements, Banu Cukurluoz Bayındır, İrem Bağ Aug 2023

The Effects Of Boric Acid On The Water Solubility Of Glass Ionomer Cements, Banu Cukurluoz Bayındır, İrem Bağ

Journal of Dentistry Indonesia

Changing the water solubility property of glass ionomer cement (GIC), which is frequently used in pediatric dentistry, is the starting point of this study. Objective: To evaluate the effects of boric acid on the water solubility (WS) of GIC. Methods: The samples were prepared as n=12 in each of four groups: GIC-Conventional glass ionomer cement; BGIC with 1:3 boric acid added to conventional GIC powder; RMGIC-resin-modified glass ionomer cement; BRMGIC with 1:3 boric acid added to RMGIC powder. Weight changes were compared 1, 3 and 24 h after keeping in distilled water. One sample in each group was …


Using A Novel To Help Sociology Students Feel Less “At Sea” In Their Sociology Of Aging Course, Roger Clark, Emily Stier Adler Aug 2023

Using A Novel To Help Sociology Students Feel Less “At Sea” In Their Sociology Of Aging Course, Roger Clark, Emily Stier Adler

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.


Permainan Alegori Dalam Novel O Karya Eka Kurniawan, Indah Fadhilla Aug 2023

Permainan Alegori Dalam Novel O Karya Eka Kurniawan, Indah Fadhilla

Paradigma: Jurnal Kajian Budaya

Fables typically attach human attributes to animal characters to convey moral messages and teachings, but a number of modern authors use animal characters in their literary works to criticize current sociocultural phenomena. One famous literary work that contains many forms of allegory about relationships between human and animal characters is O, a novel by Eka Kurniawan. Allegories in O are used to exhibit contradictions between humans and animals. Animal characters are presented as possessing human traits, bringing up the idea that animals can become ideal human beings (the concept of “being human”). Meanwhile, human characters are presented as possessing …


Perdagangan Perempuan Indonesia Dalam Situs Pengantin Pesanan: Perspektif Feminisme Sosialis, Wabilia Husnah Aug 2023

Perdagangan Perempuan Indonesia Dalam Situs Pengantin Pesanan: Perspektif Feminisme Sosialis, Wabilia Husnah

Paradigma: Jurnal Kajian Budaya

Mail-order bride websites can be easily found in cyberspace. These websites sell Indonesian women to Chinese men as wives. This study aims to explore the phenomenon of women cyber-trafficking in mail-order bride websites, especially the background of mail-order bride websites and their impacts on the victims. This qualitative research used the case study approach and the socialist feminism theory to investigate three mail-order bride websites. This study concludes that the oppression of women on mail-order bride websites is caused by long-standing patriarchy in Indonesia and China reflected in daily practices, cultural manifestations, and literary works in both countries. Capitalism has …


Efficacy Of Scalp-Sparing Volumetric-Modulated Arc Therapy Approach In Reducing Scalp Radiation Dose For Patients With Glioblastoma: A Cross-Sectional Study, Muneeb Khan Niazi, Olga Russial, Louis Cappelli, Ryan Miller, Yingxuan Chen, Yelena Vakhnenko, Haisong Lui, Wenyin Shi Aug 2023

Efficacy Of Scalp-Sparing Volumetric-Modulated Arc Therapy Approach In Reducing Scalp Radiation Dose For Patients With Glioblastoma: A Cross-Sectional Study, Muneeb Khan Niazi, Olga Russial, Louis Cappelli, Ryan Miller, Yingxuan Chen, Yelena Vakhnenko, Haisong Lui, Wenyin Shi

Department of Radiation Oncology Faculty Papers

BACKGROUND: Radiation is integral to the treatment of glioblastoma (GBM). However, radiation-induced scalp toxicity can negatively impact patients' quality of life. Volumetric modulated arc therapy (VMAT) optimizes the dose to organs at risk (OARs). We hypothesize that a scalp-sparing VMAT (SSV) approach can significantly reduce undesirable doses to the scalp without compromising the target dose.

METHODS: This is a retrospective cross-sectional study of GBM patients who originally received radiation with non-SSV. We contoured the scalp as a 5 mm rind-like structure beneath the skin above the level of the foramen magnum. We replanned our patients using SSV techniques. We compared …


First Documentation Of Least Chub In The Snake River Drainage In Idaho, Eric J. Billman, Dallin Stokes, Isaac Calderwood, Cody Diehl Aug 2023

First Documentation Of Least Chub In The Snake River Drainage In Idaho, Eric J. Billman, Dallin Stokes, Isaac Calderwood, Cody Diehl

Western North American Naturalist

The Least Chub (Iotichthys phlegethontis) is a small minnow endemic to the Bonneville Basin in Utah, where the current distribution of extant populations is limited to a few small spring complexes. We report on the first documentation of Least Chub in the upper Snake River drainage in Idaho. In June 2021, October 2021, and June 2022, we surveyed for small-bodied fishes in off-channel habitat of lower Henrys Fork in Cartier Slough Wildlife Management Area west of Rexburg, Idaho. Small-bodied fishes were sampled at 17 sites in off-channel habitat; 5 baited minnow traps (galvanized steel) were set for approximately …


Pan-Cancer Analysis Of Post-Translational Modifications Reveals Shared Patterns Of Protein Regulation, Yifat Geffen, Shankara Anand, Yo Akiyama, Tomer M Yaron, Yizhe Song, Jared L Johnson, Akshay Govindan, Özgün Babur, Yize Li, Emily Huntsman, Liang-Bo Wang, Chet Birger, David I Heiman, Qing Zhang, Mendy Miller, Yosef E Maruvka, Nicholas J Haradhvala, Anna Calinawan, Saveliy Belkin, Alexander Kerelsky, Karl R Clauser, Karsten Krug, Shankha Satpathy, Samuel H Payne, D R Mani, Michael A Gillette, Saravana M Dhanasekaran, Mathangi Thiagarajan, Mehdi Mesri, Henry Rodriguez, Ana I Robles, Steven A Carr, Alexander J Lazar, François Aguet, Lewis C Cantley, Li Ding, Gad Getz, Clinical Proteomic Tumor Analysis Consortium Aug 2023

Pan-Cancer Analysis Of Post-Translational Modifications Reveals Shared Patterns Of Protein Regulation, Yifat Geffen, Shankara Anand, Yo Akiyama, Tomer M Yaron, Yizhe Song, Jared L Johnson, Akshay Govindan, Özgün Babur, Yize Li, Emily Huntsman, Liang-Bo Wang, Chet Birger, David I Heiman, Qing Zhang, Mendy Miller, Yosef E Maruvka, Nicholas J Haradhvala, Anna Calinawan, Saveliy Belkin, Alexander Kerelsky, Karl R Clauser, Karsten Krug, Shankha Satpathy, Samuel H Payne, D R Mani, Michael A Gillette, Saravana M Dhanasekaran, Mathangi Thiagarajan, Mehdi Mesri, Henry Rodriguez, Ana I Robles, Steven A Carr, Alexander J Lazar, François Aguet, Lewis C Cantley, Li Ding, Gad Getz, Clinical Proteomic Tumor Analysis Consortium

Faculty, Staff and Student Publications

Post-translational modifications (PTMs) play key roles in regulating cell signaling and physiology in both normal and cancer cells. Advances in mass spectrometry enable high-throughput, accurate, and sensitive measurement of PTM levels to better understand their role, prevalence, and crosstalk. Here, we analyze the largest collection of proteogenomics data from 1,110 patients with PTM profiles across 11 cancer types (10 from the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium [CPTAC]). Our study reveals pan-cancer patterns of changes in protein acetylation and phosphorylation involved in hallmark cancer processes. These patterns revealed subsets of tumors, from different cancer types, including those with …


Wearable Biosensor With Molecularly Imprinted Conductive Polymer Structure To Detect Lentivirus In Aerosol, Jaskirat Singh Batra, Ting-Yen Chi, Mo-Fan Huang, Dandan Zhu, Zheyuan Chen, Dung-Fang Lee, Jun Kameoka Aug 2023

Wearable Biosensor With Molecularly Imprinted Conductive Polymer Structure To Detect Lentivirus In Aerosol, Jaskirat Singh Batra, Ting-Yen Chi, Mo-Fan Huang, Dandan Zhu, Zheyuan Chen, Dung-Fang Lee, Jun Kameoka

Faculty, Staff and Student Publications

The coronavirus disease (COVID-19) pandemic has increased pressure to develop low-cost, compact, user-friendly, and ubiquitous virus sensors for monitoring infection outbreaks in communities and preventing economic damage resulting from city lockdowns. As proof of concept, we developed a wearable paper-based virus sensor based on a molecular imprinting technique, using a conductive polyaniline (PANI) polymer to detect the lentivirus as a test sample. This sensor detected the lentivirus with a 4181 TU/mL detection limit in liquid and 0.33% to 2.90% detection efficiency in aerosols at distances ranging from 30 cm to 60 cm. For fabrication, a mixture of a PANI monomer …


Validation Of A Biomechanical Injury And Disease Assessment Platform Applying An Inertial-Based Biosensor And Axis Vector Computation, Wangdo Kim, Emir A. Vela, Sean S. Kohles, Victor Huayamave Aug 2023

Validation Of A Biomechanical Injury And Disease Assessment Platform Applying An Inertial-Based Biosensor And Axis Vector Computation, Wangdo Kim, Emir A. Vela, Sean S. Kohles, Victor Huayamave

Publications

Inertial kinetics and kinematics have substantial influences on human biomechanical function. A new algorithm for Inertial Measurement Unit (IMU)-based motion tracking is presented in this work. The primary aims of this paper are to combine recent developments in improved biosensor technology with mainstream motion-tracking hardware to measure the overall performance of human movement based on joint axis-angle representations of limb rotation. This work describes an alternative approach to representing three-dimensional rotations using a normalized vector around which an identified joint angle defines the overall rotation, rather than a traditional Euler angle approach. Furthermore, IMUs allow for the direct measurement of …


Evaluation Of A Faculty Fellows Program In Science Communication, Stacy Stanifer, Beverly Delidow, Kathy Rademacher, Luz Huntington-Moskos, Kelly Kennoy, Amanda Thaxton-Wiggins, Craig Wilmhoff, Ellen J. Hahn Aug 2023

Evaluation Of A Faculty Fellows Program In Science Communication, Stacy Stanifer, Beverly Delidow, Kathy Rademacher, Luz Huntington-Moskos, Kelly Kennoy, Amanda Thaxton-Wiggins, Craig Wilmhoff, Ellen J. Hahn

Journal of Appalachian Health

Introduction: Science communication plays a crucial role in tackling pressing regional, national, and global health issues. Effective communication with various audiences is integral to dissemination of science findings.

Purpose: This study evaluates changes in self-efficacy and attitudes toward science communication skills over time and also assesses program outcomes and satisfaction with a Faculty Fellows in Science Communication (FFSC) program among faculty (N = 30) with interest in environmental health science and/or education in Appalachia Kentucky.

Methods: A mixed methods program evaluation was employed using longitudinal data on behaviors, attitudes, and program outcomes from three cohorts of Faculty Fellows who participated …


Identification Of Distinct Impacts Of Covs Inactivation On The Transcriptome Of Acapsular Group A Streptococci, Sruti Debroy, William C Shropshire, Luis Vega, Chau Tran, Nicola Horstmann, Piyali Mukherjee, Selvalakshmi Selvaraj-Anand, Truc T Tran, Jordan Bremer, Marc Gohel, Cesar A Arias, Anthony R Flores, Samuel A Shelburne Aug 2023

Identification Of Distinct Impacts Of Covs Inactivation On The Transcriptome Of Acapsular Group A Streptococci, Sruti Debroy, William C Shropshire, Luis Vega, Chau Tran, Nicola Horstmann, Piyali Mukherjee, Selvalakshmi Selvaraj-Anand, Truc T Tran, Jordan Bremer, Marc Gohel, Cesar A Arias, Anthony R Flores, Samuel A Shelburne

Faculty, Staff and Student Publications

Group A streptococcal (GAS) strains causing severe, invasive infections often have mutations in the control of virulence two-component regulatory system (CovRS) which represses capsule production, and high-level capsule production is considered critical to the GAS hypervirulent phenotype. Additionally, based on studies in emm1 GAS, hyperencapsulation is thought to limit transmission of CovRS-mutated strains by reducing GAS adherence to mucosal surfaces. It has recently been identified that about 30% of invasive GAS strains lacks capsule, but there are limited data regarding the impact of CovS inactivation in such acapsular strains. Using publicly available complete genomes (n = 2,455) of invasive …


Sexually Dimorphic Extracellular Vesicle Responses After Chronic Spinal Cord Injury Are Associated With Neuroinflammation And Neurodegeneration In The Aged Brain, Yun Li, Niaz Khan, Rodney M Ritzel, Zhuofan Lei, Samantha Allen, Alan I Faden, Junfang Wu Aug 2023

Sexually Dimorphic Extracellular Vesicle Responses After Chronic Spinal Cord Injury Are Associated With Neuroinflammation And Neurodegeneration In The Aged Brain, Yun Li, Niaz Khan, Rodney M Ritzel, Zhuofan Lei, Samantha Allen, Alan I Faden, Junfang Wu

Faculty, Staff and Student Publications

Background

Medical advances have made it increasingly possible for spinal cord injury (SCI) survivors to survive decades after the insult. But how SCI affects aging changes and aging impacts the injury process have received limited attention. Extracellular vesicles (EVs) are recognized as critical mediators of neuroinflammation after CNS injury, including at a distance from the lesion site. We have previously shown that SCI in young male mice leads to robust changes in plasma EV count and microRNA (miR) content. Here, our goal was to investigate the impact of biological sex and aging on EVs and brain after SCI.

Methods

Young …


Performance Of Urinary Phenyl-Γ-Valerolactones As Biomarkers Of Dietary Flavan-3-Ol Exposure, Benjamin H. Parmenter, Sujata Shinde, Kevin Croft, Kevin Murray, Catherine P. Bondonno, Angela Genoni, Claus T. Christophersen, Keren Bindon, Colin Kay, Pedro Mena, Daniele Del Rio, Jonathan M. Hodgson, Nicola P. Bondonno Aug 2023

Performance Of Urinary Phenyl-Γ-Valerolactones As Biomarkers Of Dietary Flavan-3-Ol Exposure, Benjamin H. Parmenter, Sujata Shinde, Kevin Croft, Kevin Murray, Catherine P. Bondonno, Angela Genoni, Claus T. Christophersen, Keren Bindon, Colin Kay, Pedro Mena, Daniele Del Rio, Jonathan M. Hodgson, Nicola P. Bondonno

Research outputs 2022 to 2026

Background: Phenyl- -valerolactones (PVLs) have been identified as biomarkers of dietary flavan-3-ol exposure, although their utility requires further characterization. Objectives: We investigated the performance of a range of PVLs as biomarkers indicative of flavan-3-ol intake. Methods: We report the results of 2 companion studies: a 5-way randomized crossover trial (RCT) and an observational cross-sectional study. In the RCT (World Health Organization, Universal Trial Number: U1111-1236-7988), 16 healthy participants consumed flavan-3-ol–rich interventions (of apple, cocoa, black tea, green tea, or water [control]) for 1 d each. First morning void samples and 24-h urine samples were collected with diet standardized throughout. For …


Pláticas Liberadoras: Testimonios Of Chicana/O Elders En La Comunidad De San Diego, Gabriel Nunez-Soria Aug 2023

Pláticas Liberadoras: Testimonios Of Chicana/O Elders En La Comunidad De San Diego, Gabriel Nunez-Soria

Dissertations

There is robust scholarship inquiring about many facets of critical consciousness (CC), most of which is centered around working with teens, youth, and educators. This study explored development of CC through testimonios of the lived experiences of eight Chicana/o elders in San Diego County. All eight of these elders participated in the Chicana/o movement during the late 1960s and early 1970s and carried these experiences with them into the present moment. Development of CC, the contextualized understandings of historical, social, and systemic aspects of our collective struggle against oppression through dialogue, reflection, and action, is a fundamental aspect of liberatory …


Kenyon Collegian - August 31, 2023 Aug 2023

Kenyon Collegian - August 31, 2023

The Kenyon Collegian

No abstract provided.


Nanodiscs: A Novel Approach To The Study Of The Methionine Abc Transporter System, Michael T. Winslow Aug 2023

Nanodiscs: A Novel Approach To The Study Of The Methionine Abc Transporter System, Michael T. Winslow

Master's Theses

Membrane transporter proteins play the vital role of moving compounds in and out of the cell and are essential for all living organisms. ATP Binding Cassette (ABC) family transporters function both as importers and exporters in prokaryotes. MetNI is an E. coli Type I ABC transporter responsible for the uptake of methionine into the cytosol from the cell periplasmic space through the cell membrane to maintain intracellular methionine pools. ABC transporters, like other membrane proteins, are most often mechanistically and structurally studied in vitro, solubilized by detergents. However, detergent micelles may affect the conformational changes of membrane proteins relative to …


The Effects Of Acculturation, Marianismo, And Religiosity On Pregnancy Related Anxiety In Latina Women, Jennifer M. Zanoli Aug 2023

The Effects Of Acculturation, Marianismo, And Religiosity On Pregnancy Related Anxiety In Latina Women, Jennifer M. Zanoli

Doctoral Dissertations

There is a dearth of information about pregnancy related anxiety (PRA) in Latina women, yet a growing body of literature demonstrates adverse birth outcomes for mother and infant due to PRA. This study examined the association between acculturation, religiosity, marianismo, parity, and a Latina pregnant woman’s relationship with her healthcare provider with PRA in Latina women aged 18 and above. Acculturation was expected to be the more robust factor amongst the independent variables.

Participants in this study (n = 53) were Hispanic, Chicano, Latino or had a Latin or Spanish heritage, over the age of 18, pregnant at the …


Mental Health And Experiences Of Pregnancy Among Black Women And Birthing People With Type 1 Diabetes (T1d), Madeleine E. Marcus Aug 2023

Mental Health And Experiences Of Pregnancy Among Black Women And Birthing People With Type 1 Diabetes (T1d), Madeleine E. Marcus

Doctoral Dissertations

This dissertation explored the potential effects of intersections of oppression (i.e., anti-Black racism, diabetes discrimination, and sexism) on mental health and pregnancy experiences among Black women and birthing people with Type 1 diabetes (T1D). Previous studies about pregnancy and T1D have included mainly white, cisgender women. Three participants qualified for inclusion in the present study and participated in semi-structured interviews, which the researcher analyzed using an interpretative phenomenological analysis (IPA) framework. Participants described feeling uncertain about whether aspects of their pregnancy experiences were related to obstetric and/or medical racism. Similarly, participants sometimes seemed uncertain about how racism may affect their …