Digital Commons Network^™

Episode 2: State Of The Union, Sara Gras

Season 01

Episode 2 looks at the recent legislative push to ban transgender kids from scholastic sports across the country in the context of the anti-trans bathroom bans that preceded it. I also dive into the Soule v. Connecticut case that is so frequently referenced as an example of trans athlete exceptionalism despite the actual facts. There will be more later in the season on the organizations encouraging the passage of sports bans and supporting their defense in court, but my guests in this episode start to shed some light on who they are and what motivates their actions. I extend my …

The Utah Statesman, October 9, 2023, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

The Rider (2023-10-09), Natalie Lapsley

The Rider Archives

Vol.9 No.7

The Minutes Of The Marshall University Graduate Council Meeting, September 29, 2023, Marshall University Graduate Council

Graduate Council Minutes

No abstract provided.

Shadow Report Submissions And Updates Compiled By The International Human Rights Clinic At University Of Illinois Chicago School Of Law And Program On Human Rights And The Global Economy At Northeastern University School Of Law, Sarah A. Dávila Et Al.

Faculty White Papers

No abstract provided.

Investigating The Environmental Weathering Of Plastics Used Within The Agricultural Fields, Gholamreza .. Bonyadinejad

Electronic Theses and Dissertations Archive

The soaring accumulation of discarded plastics in the environment is a pressing global issue, primarily driven by increased plastic usage and improper waste management. From 2012 to 2019, among various applications of plastic products, the global utilization of plastics in agriculture witnessed a notable rise, surging from 4.4 million tons to 7.4 million tons, creating plastic pollution problems. Plastic pollution within the farmlands threatens food safety and negatively impacts soil health. Therefore, this dissertation focuses on studying the environmental weathering of plastic residuals within the terrestrial environment and investigating their impacts on the plastic particles' fate within the aquatic systems. …

Proceedings Of Iasdr 2023: Life-Changing Design, Daniela De Sainz Molestina, Laura Galluzzo, Francesca Rizzo, Davide Spallazzo

DRS Conference Volumes

This volume is the proceedings of the 10th biennial congress of IASDR, the International Association for Societies of Design Research, hosted by the Politecnico di Milano, 9–13 October 2023. With its overarching theme of “Life-Changing Design” and its diverse thematic tracks, IASDR2023 presented an exceptional opportunity for researchers, scholars, and practitioners to engage with the dynamic landscape of design research. The conference served as a platform for robust discussions, knowledge sharing, and the exploration of innovative solutions to society’s complex challenges. By examining these thematic tracks and their intersection with the central theme, “Life-Changing Design,” the conference contributed to the …

Assembly Of An Inexpensive Rat Jugular Catheter Button Based On A Split-Septum Needleless Intravenous System, Mauricio Suarez, Elizabeth J. Cantrell, Ken T. Wakabayashi, Caroline E. Bass

Department of Psychology: Faculty Publications

Rat intravenous self-administration is a widely-used animal model in the study of substance use disorders. Rats are tethered to a drug delivery system usually through a port or button that inter- faces the drug delivery system with a chronic indwelling jugular vein catheter. These buttons can be purchased commercially but are costly, presenting a significant economic barrier for many researchers. Many researchers manufacture buttons in-house from a combination of individual custom made and commercially available components, resulting in large variation in terms of how the animals are handled and the longevity of catheter patency. We have developed a jugular catheter …

Crow's Nest, October 9, 2023, Crow's Nest Staff

Crow's Nest

The October 9, 2023, issue of the Crow's Nest.

Quantification Of Amu River Riverbank Erosion In Balkh Province Of Afghanistan During 2004–2020, Abdul Basir Mahmoodzada, Divyesh Varade, Sawahiko Shimada, Hiromu Okazawa, Shafiqullah Aryan, Gulbuddin Gulab, Abd El Zaher M.A. Mustafa, Humaira Rizwana, Yogesh Ahlawat, Hosam O. Elansary

Michigan Tech Publications

In this study, we propose quantifying the Amu River riverbank erosion with the modelled river discharge in Kaldar District, Balkh Province of Afghanistan from 2004 to 2020. We propose a framework synergizing multi-source information for modelling the erosion area based on three components: (1) river discharge, (2) river width, and (3) erosion area. The total river discharge for the watershed shared by Afghanistan and Tajikistan was modelled using hydrological parameters from the European Centre for Medium-Range Weather Forecasts (ECMWF) Reanalysis v5 (ERA5) data through multivariate linear regression with ground station data. The river width was determined manually using the Normalized …

The Echo: October 9, 2023, Taylor University

2023-2024 (Volume 111)

No abstract provided.

Focus, 2023, Summer, Andrews University

Focus

FOCUS (ISSN 1077-9345) is published quarterly, free of charge, for alumni and friends of Andrews University, an institution owned and operated by the Seventh-day Adventist Church.

Mathematical Modeling Of Radiotherapy: Impact Of Model Selection On Estimating Minimum Radiation Dose For Tumor Control, Achyudhan R Kutuva, Jimmy J Caudell, Kosj Yamoah, Heiko Enderling, Mohammad U Zahid

Faculty, Staff and Student Publications

INTRODUCTION: Radiation therapy (RT) is one of the most common anticancer therapies. Yet, current radiation oncology practice does not adapt RT dose for individual patients, despite wide interpatient variability in radiosensitivity and accompanying treatment response. We have previously shown that mechanistic mathematical modeling of tumor volume dynamics can simulate volumetric response to RT for individual patients and estimation personalized RT dose for optimal tumor volume reduction. However, understanding the implications of the choice of the underlying RT response model is critical when calculating personalized RT dose.

METHODS: In this study, we evaluate the mathematical implications and biological effects of 2 …

Znf683 Marks A Cd8+ T Cell Population Associated With Anti-Tumor Immunity Following Anti-Pd-1 Therapy For Richter Syndrome, Erin M Parry, Camilla K Lemvigh, Stephanie Deng, Nathan Dangle, Neil Ruthen, Binyamin A Knisbacher, Julien Broséus, Sébastien Hergalant, Romain Guièze, Shuqiang Li, Wandi Zhang, Connor Johnson, Jaclyn M Long, Shanye Yin, Lillian Werner, Annabelle Anandappa, Noelia Purroy, Satyen Gohil, Giacomo Oliveira, Pavan Bachireddy, Sachet A Shukla, Teddy Huang, Joseph D Khoury, Beenu Thakral, Michael Dickinson, Constantine Tam, Kenneth J Livak, Gad Getz, Donna Neuberg, Pierre Feugier, Peter Kharchenko, William Wierda, Lars Rønn Olsen, Nitin Jain, Catherine J Wu

Faculty, Staff and Student Publications

Unlike many other hematologic malignancies, Richter syndrome (RS), an aggressive B cell lymphoma originating from indolent chronic lymphocytic leukemia, is responsive to PD-1 blockade. To discover the determinants of response, we analyze single-cell transcriptome data generated from 17 bone marrow samples longitudinally collected from 6 patients with RS. Response is associated with intermediate exhausted CD8 effector/effector memory T cells marked by high expression of the transcription factor ZNF683, determined to be evolving from stem-like memory cells and divergent from terminally exhausted cells. This signature overlaps with that of tumor-infiltrating populations from anti-PD-1 responsive solid tumors. ZNF683 is found to directly …

Ccdc50 Promotes Tumor Growth Through Regulation Of Lysosome Homeostasis, Penghui Jia, Tian Tian, Zibo Li, Yicheng Wang, Yuxin Lin, Weijie Zeng, Yu Ye, Miao He, Xiangrong Ni, Ji'an Pan, Xiaonan Dong, Jian Huang, Chun-Mei Li, Deyin Guo, Panpan Hou

Faculty, Staff and Student Publications

The maintenance of lysosome homeostasis is crucial for cell growth. Lysosome-dependent degradation and metabolism sustain tumor cell survival. Here, we demonstrate that CCDC50 serves as a lysophagy receptor, promoting tumor progression and invasion by controlling lysosomal integrity and renewal. CCDC50 monitors lysosomal damage, recognizes galectin-3 and K63-linked polyubiquitination on damaged lysosomes, and specifically targets them for autophagy-dependent degradation. CCDC50 deficiency causes the accumulation of ruptured lysosomes, impaired autophagic flux, and superfluous reactive oxygen species, consequently leading to cell death and tumor suppression. CCDC50 expression is associated with malignancy, progression to metastasis, and poor overall survival in human melanoma. Targeting CCDC50 …

A Completely Digital Workflow Of An Interim Complete Arch Fixed Implant Prosthesis Using A Novel High-Performance 3d Printed Polymer, Steven J. Sadowsky, Jeffrey W. Stansbury

Pacific Faculty Work

The advent of osseointegration has offered a quantum shift in treatment planning patients with missing teeth. Patients with a terminal dentition or edentulous arch have become candidates for a fixed rehabilitation with immediate function. A striking limitation of this modality, however, has been the mechanical failure rate of the reconstructions, especially the interim prostheses. This clinical report describes a completely digital workflow and additive manufacturing of an interim complete arch fixed implant prosthesis, immediately placed after extraction. The prosthesis is supported by four immediately loaded implants on the maxillary arch, using stackable guides and the use of a novel 3D …

Evaluation Of Land Preparation Methods For Soil Stabilization, Revegetation, And Renewed Productivity In Semi-Arid Climates, Jarrett Lardy, North Dakota State University, Miranda Meehan, Aaron L. M. Daigh, James Staricka, Nathan Derby

Department of Agronomy and Horticulture: Faculty Publications

In the Williston Basin, land-preparation treatments have not been compared in side-by-side trials to evaluate performance for parameters such as runoff, erosion, and vegetation establishment. Thus, four treatments of wheat-straw crimping, land imprinting, wood-fiber hydromulch, and the combination of land imprinting and hydromulch were evaluated against a bare soil control in a replicated and randomized completed block field experiment near Williston, ND. Rainfall simulations were performed in September 2020 and June 2021 to examine the effectiveness of the treatments to reduce runoff and sediment losses. Vegetation establishment was also evaluated in August 2021. The wheat straw treatment reduced the equivalent …

Intouch Week Of October 9, 2023, New York Medical College

InTouch

• Founder's Dinner 2023
• Robert D. Holland M.D., M.H.A., Appointed to Lead the Department of Rehabilitation Medicine
• Diverse Manikins Deliver Inclusive Learning Experience
• Neurology and Neurosurgery Departments Host Second Annual Neuroscience Research Symposium
• NYMC Observes World Mental Health Day: October 10
• NYMC Goes Pink for Breast Cancer Awareness Month
• NYMC Research | Paul Arnaboldi, Ph.D.
• Katherine Paulino-Gomez, M.A., CCC-SLP, Brings Unique Perspective to SLP Faculty

Metabolomic Insights Into Tuberculosis: Machine Learning Approaches For Biomarker Identification, Miftahul Khair Akbar, Arief Aulia Rahman

Indonesian Journal of Medical Chemistry and Bioinformatics

The lung parenchyma is largely impacted by the infectious condition known as pulmonary tuberculosis (pulmonary TB) when the immune system creates a wall around the germs in the lungs, a tiny, hard bulge known as a tubercle develops, earning the disease the name tuberculosis. Although the majority of TB germs target the lungs, they can also harm other bodily organs. The identification of TB biomarkers, which are crucial for diagnosis, treatment monitoring, risk analysis, and prognosis, has been the subject of extensive research. Differences in metabolites between normal cells and tuberculosis are considered to be able to support the diagnosis …

Scope And Mechanism Of The Ruthenium-Catalyzed Deaminative Coupling Reaction Of Enones With Amines Via Regioselective CΑ–CΒ Bond Cleavage, Marat R. Talipov, Dulanjali S. Thennakoon, Chae S. Yi

Chemistry Faculty Research and Publications

A highly regioselective C–C bond cleavage method of enones has been devised from the ruthenium-catalyzed deaminative coupling reaction with simple amines. The analogous catalytic coupling reaction of enones with anilines has led to a regioselective C_α–C_β bond cleavage of enones in forming N-alkylanilines and 2,4-disubstituted quinolines. The reaction profile study showed the formation of a β-aminoimine intermediate prior to the C–C cleavage product formation. A Hammett plot from the reaction of (E)-2-octen-4-one with a series of para-substituted benzylamines established a strong promotional effect by an electron-donating group (ρ = −0.77 ± 0.1). The …

Enzyme-Mediated Depletion Of Methylthioadenosine Restores T Cell Function In Mtap-Deficient Tumors And Reverses Immunotherapy Resistance, Donjeta Gjuka, Elio Adib, Kendra Garrison, Jianfeng Chen, Yuxue Zhang, Wenjiao Li, Daniel Boutz, Candice Lamb, Yuri Tanno, Amin Nassar, Talal El Zarif, Neil Kale, Mehrdad Rakaee, Tarek H Mouhieddine, Sarah Abou Alaiwi, Alexander Gusev, Thomas Rogers, Jianjun Gao, George Georgiou, David J Kwiatkowski, Everett Stone

Faculty, Staff and Student Publications

Chromosomal region 9p21 containing tumor suppressors CDKN2A/B and methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic deletions in cancer. 9p21 loss is correlated with reduced tumor-infiltrating lymphocytes (TILs) and resistance to immune checkpoint inhibitor (ICI) therapy. Previously thought to be caused by CDKN2A/B loss, we now show that it is loss of MTAP that leads to poor outcomes on ICI therapy and reduced TIL density. MTAP loss causes accumulation of methylthioadenosine (MTA) both intracellularly and extracellularly and profoundly impairs T cell function via the inhibition of protein arginine methyltransferase 5 (PRMT5) and by adenosine receptor agonism. Administration of …

Blood-Based Transcriptomic Biomarkers Are Predictive Of Neurodegeneration Rather Than Alzheimer's Disease, Artur Shvetcov, Shannon Thomson, Jessica Spathos, Ann-Na Cho, Heather M Wilkins, Shea J Andrews, Fabien Delerue, Timothy A Couttas, Jasmeen Kaur Issar, Finula Isik, Simranpreet Kaur, Eleanor Drummond, Carol Dobson-Stone, Shantel L Duffy, Natasha M Rogers, Daniel Catchpoole, Wendy A Gold, Russell H Swerdlow, David A Brown, Caitlin A Finney

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is a growing global health crisis affecting millions and incurring substantial economic costs. However, clinical diagnosis remains challenging, with misdiagnoses and underdiagnoses being prevalent. There is an increased focus on putative, blood-based biomarkers that may be useful for the diagnosis as well as early detection of AD. In the present study, we used an unbiased combination of machine learning and functional network analyses to identify blood gene biomarker candidates in AD. Using supervised machine learning, we also determined whether these candidates were indeed unique to AD or whether they were indicative of other neurodegenerative diseases, such as …

Review Of Wild Sound: Maryanne Amacher And The Tenses Of Audible Life, By Amy Cimini, Charissa Noble

Music: Faculty Scholarship

The first book dedicated to the life and work of composer Maryanne Amacher (1938- 2009), Wild Sound: Maryanne Amacher and the Tenses of Audible Life begins in medias res. Author Amy Cimini introduces us to Amacher by peering into one of her brainstorming sessions, depicting an imaginative scene set in the 1990s at Mills College. Cimini describes Amacher seated at her desk, passionately inscribing a “big quote” (announced in “heavy black Sharpie,” Cimini notes) from feminist scholar Donna Haraway’s Simians, Cyborgs and Women (1991): “I want a feminist writing….” Then, as Amacher ponders the quote’s implications for her own creative …

Clinical Characteristics Of Monkeypox Vaccine Injection Site Reactions: A Cohort Of Seven Patients, Anthony A. Gaspari

Department of Dermatology and Cutaneous Biology Faculty Papers

Background

Monkeypox (Mpox) infections are considered a public health emergency, prompting the need for the administration of a preventative vaccine to high-risk individuals.

Objectives

To describe the clinical course of dermatologic reactions to Mpox vaccine over time.

Methods

Seven recipients of the Mpox vaccine, administered via intradermal injection, were observed over time, and the dermatologic reactions to this vaccine were recorded.

Results

All seven recipients experienced mild to moderate localized reactions to Mpox vaccine to either the primary or booster injections. These reactions were characterized by erythema, induration and pruritus. These reactions eventually healed without any sustained reactions, eschar or …

A Small De Novo Cnv Deletion Of The Paternal Copy Of Foxf1, Leaving Lncrna Fendrr Intact, Provides Insight Into Their Bidirectional Promoter Region, Przemyslaw Szafranski, Paweł Stankiewicz

Faculty, Staff and Students Publications

Pathogenic single-nucleotide variants (SNVs) and copy-number variant (CNV) deletions involving the FOXF1 transcription factor gene or CNV deletions of its distant lung-specific enhancer are responsible for alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), a rarely diagnosed lethal lung developmental disorder in neonates. In contrast to SNVs within FOXF1 and CNV deletions involving only the FOXF1 enhancer, larger-sized deletions involving FOXF1 and the adjacent, oppositely oriented lncRNA gene FENDRR have additionally been associated with hypoplastic left heart syndrome and single umbilical artery (SUA). Here, in an ACDMPV infant without any congenital heart defect or SUA, we identified a small …

Sox7-Positive Endothelial Progenitors Establish Coronary Arteries And Govern Ventricular Compaction, Ivy Kn Chiang, David Humphrey, Richard J Mills, Peter Kaltzis, Shikha Pachauri, Matthew Graus, Diptarka Saha, Zhijian Wu, Paul Young, Choon Boon Sim, Tara Davidson, Andres Hernandez-Garcia, Chad A Shaw, Alexander Renwick, Daryl A Scott, Enzo R Porrello, Emily S Wong, James E Hudson, Kristy Red-Horse, Gonzalo Del Monte-Nieto, Mathias Francois

Faculty, Staff and Students Publications

The cardiac endothelium influences ventricular chamber development by coordinating trabeculation and compaction. However, the endothelial-specific molecular mechanisms mediating this coordination are not fully understood. Here, we identify the Sox7 transcription factor as a critical cue instructing cardiac endothelium identity during ventricular chamber development. Endothelial-specific loss of Sox7 function in mice results in cardiac ventricular defects similar to non-compaction cardiomyopathy, with a change in the proportions of trabecular and compact cardiomyocytes in the mutant hearts. This phenotype is paralleled by abnormal coronary artery formation. Loss of Sox7 function disrupts the transcriptional regulation of the Notch pathway and connexins 37 and 40, …

Lipidome Of Mammographic Breast Density In Premenopausal Women, Kayla R Getz, Myung Sik Jeon, Chongliang Luo, Jingqin Luo, Adetunji T Toriola

2020-Current year OA Pubs

BACKGROUND: High mammographic breast density (MBD) is a strong risk factor for breast cancer development, but the biological mechanisms underlying MBD are unclear. Lipids play important roles in cell differentiation, and perturbations in lipid metabolism are implicated in cancer development. Nevertheless, no study has applied untargeted lipidomics to profile the lipidome of MBD. Through this study, our goal is to characterize the lipidome of MBD in premenopausal women.

METHODS: Premenopausal women were recruited during their annual screening mammogram at the Washington University School of Medicine in St. Louis, MO. Untargeted lipidomic profiling for 982 lipid species was performed at Metabolon …

When It Happens Here: Reproductive Autonomy, Fascism, And Dobbs V. Jackson Women’S Health Organization, Robin Maril

Pace Law Review

Within six months after the U.S. Supreme Court’s decision in Dobbs v. Jackson Women’s Health Organization, nineteen states passed laws prohibiting abortion within the first trimester. The most restrictive laws banned abortion entirely, except to save the life of the person giving birth. The Court’s eager abdication of its role in protecting individual liberty under the 14th amendment marks a grim chapter in the life cycle of American democracy. The Dobbs decision, along with the political environment that demanded the repeal of Roe v. Wade, promises to severely limit the role of women in public life. The specter …

Homogenization And Thermal Processing Reduce The Concentration Of Extracellular Vesicles In Bovine Milk, Anna P. Colella, Anuradha Prakash, John Miklavcic

Food Science Faculty Articles and Research

Extracellular vesicles (EVs) in bovine milk confer beneficial physiologic effects to consumers. Industrial processing treatments may affect the amount or bioactivity of EVs intrinsic to bovine milk. We investigated how the content and concentration of EVs were affected by homogenization and thermal processing of raw bovine milk. Raw milk was processed by homogenization, low-temperature (LT) heat, or pasteurization [high-temperature short-time (HTST) and ultra-high-temperature (UHT)] in a pilot processing facility. EVs were isolated from the raw and processed bovine milk using differential ultracentrifugation and quantified using a nanoparticle tracking analyzer. Bovine milk EVs were assessed for total miRNA and protein concentrations …

Irrigation Increases On-Farm Soybean Yields In Water-Limited Environments Without A Trade-Off In Seed Protein Concentration, Walter D. Carciochi, Patricio Grassini, Seth Naeve, James E. Specht, Mitiku Mamo, Ron Seymour, Aaron Nygren, Nathan Mueller, Sarah Sivits, Christopher A. Proctor, Jenny Rees, Todd Whitney, N. Cafaro La Menza

Department of Agronomy and Horticulture: Faculty Publications

Context or problem: A trade-off between seed protein concentration (SPC) and yield has been reported for soybean. Therefore, assessing management practices that can nullify this trade-off is relevant to avoid further declines in SPC in the future as yield continues to increase. While the positive effect of irrigation on yield is well documented, only a few studies have assessed the impact of irrigation on SPC, showing conflicting results.

Objective or research question: The objective was to determine if the trade-off between seed yield and SPC persists when irrigation is applied and how management, soil, and weather factors influence the trade-off. …