Digital Commons Network^™

Neuroprotective Activity Of Enantiomers Of Salsolinol And N-Methyl-(R)-Salsolinol: In Vitro And In Silico Studies, Magdalena Kurnik-Łucka, Gniewomir Latacz, Adam Bucki, Mario Rivera-Meza, Nadia Khan, Jahnobi Konwar, Kamil Skowron, Marcin Kołaczkowski, Krzysztof Gil

Faculty, Staff and Student Publications

Salsolinol (1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol) is a close structural analogue of dopamine with an asymmetric center at the C1 position, and its presence in vivo, both in humans and rodents, has already been proven. Yet, given the fact that salsolinol colocalizes with dopamine-rich regions and was first detected in the urine of Parkinson's disease patients, its direct role in the process of neurodegeneration has been proposed. Here, we report that

Preantral Follicle Morphometry And Ultrastructure Of Antral Follicles In Anatolian Water Buffalo, Duygu Baki̇ Acar, Muhammed Kürşad Bi̇rdane, Çi̇ğdem Tokyol, Nermi̇n Nüket Göçmen Karabeki̇r, Hati̇ce Mürvet Hayran, Erhan Özenç, Fatma Aktepe, Ebubeki̇r Yazici, İlknur Pi̇r Yağci, Mehmet Uçar

Turkish Journal of Veterinary & Animal Sciences

This study aimed to evaluate quantitative and morphometric analyses of preantral follicles and the ultrastructural characteristics of antral follicles in different oestrous cycle stages in Anatolian water buffaloes. Twenty-four ovaries collected from twelve slaughtered Anatolian water buffaloes were classified macroscopically as luteal or follicular stages. The ovaries were prepared for histological examination (Hematoxylin-eosin staining), and primordial, primary, and secondary follicle numbers were calculated, and the diameters of oocytes, follicles, and nuclei were measured under a light microscope with a micrometre. The theca and granulosa cells of antral follicles were observed under a transmission electron microscope. The mean number of preantral …

Determining The Protective Effect Of A Boron Adjuvanted Vaccine With An Experimental Infection Model In Mice, Zafer Sayin, Ali̇ Uslu, Özgür Özdemi̇r, Abdullah Başoğlu, Asli Balevi̇, Uçkun Sai̇t Uçan, Zeki̇ Aras, Osman Ergani̇ş

Turkish Journal of Veterinary & Animal Sciences

Boron is a required trace element for plants, humans, and animals and it has significant influence over biological functions and the immune system. Vaccines have aided humans in the control of many contagious diseases around the world. The success of global immunization campaigns may be possible with the development of effective and low-cost vaccines and adjuvants. For this reason, the present study aimed to determine the adjuvant activity of easily accessible boron compounds. In this study, six different vaccines were prepared, including inactive Staphylococcus aureus bacteria, boric acid, aluminum hydroxide, montanide ISA 50, and ISA 206, ISA 50 + boric …

Association Between Whole Blood-Derived Mitochondrial Dna Copy Number, Low-Density Lipoprotein Cholesterol, And Cardiovascular Disease Risk, Xue Liu, Xianbang Sun, Yuankai Zhang, Wenqing Jiang, Meng Lai, Kerri L Wiggins, Laura M Raffield, Lawrence F Bielak, Wei Zhao, Achilleas Pitsillides, Jeffrey Haessler, Yinan Zheng, Thomas W Blackwell, Jie Yao, Xiuqing Guo, Yong Qian, Bharat Thyagarajan, Nathan Pankratz, Stephen S Rich, Kent D Taylor, Patricia A Peyser, Susan R Heckbert, Sudha Seshadri, Eric Boerwinkle, Megan L Grove, Nicholas B Larson, Jennifer A Smith, Ramachandran S Vasan, Annette L Fitzpatrick, Myriam Fornage, Jun Ding, April P Carson, Goncalo Abecasis, Josée Dupuis, Alexander Reiner, Charles Kooperberg, Lifang Hou, Bruce M Psaty, James G Wilson, Daniel Levy, Jerome I Rotter, Joshua C Bis, Claudia L Satizabal, Dan E Arking, Chunyu Liu

Faculty, Staff and Student Publications

Background The relationship between mitochondrial DNA copy number (mtDNA CN) and cardiovascular disease remains elusive. Methods and Results We performed cross-sectional and prospective association analyses of blood-derived mtDNA CN and cardiovascular disease outcomes in 27 316 participants in 8 cohorts of multiple racial and ethnic groups with whole-genome sequencing. We also performed Mendelian randomization to explore causal relationships of mtDNA CN with coronary heart disease (CHD) and cardiometabolic risk factors (obesity, diabetes, hypertension, and hyperlipidemia).

Hippo Pathway Knockdown Gene Therapy In The Heart, Todd R Heallen, James F Martin

The Texas Heart Institute Journal

No abstract provided.

International Consensus On Differential Diagnosis And Management Of Patients With Danon Disease: Jacc State-Of-The-Art Review, Kimberly N Hong, Emily A Eshraghian, Michael Arad, Alessia Argirò, Michela Brambatti, Quan Bui, Oren Caspi, Fernando De Frutos, Barry Greenberg, Carolyn Y Ho, Juan Pablo Kaski, Iacopo Olivotto, Matthew R G Taylor, Abigail Yesso, Pablo Garcia-Pavia, Eric D Adler

Faculty, Staff and Students Publications

Danon disease is a rare X-linked autophagic vacuolar cardioskeletal myopathy associated with severe heart failure that can be accompanied with extracardiac neurologic, skeletal, and ophthalmologic manifestations. It is caused by loss of function variants in the LAMP2 gene and is among the most severe and penetrant of the genetic cardiomyopathies. Most patients with Danon disease will experience symptomatic heart failure. Male individuals generally present earlier than women and die of either heart failure or arrhythmia or receive a heart transplant by the third decade of life. Herein, the authors review the differential diagnosis of Danon disease, diagnostic criteria, natural history, …

Regulation Of Postnatal Cardiomyocyte Maturation By An Rna Splicing Regulator Rbfox1, Jijun Huang, Josh Z Lee, Christoph D Rau, Arash Pezhouman, Tomohiro Yokota, Hiromi Miwa, Matthew Feldman, Tsz Kin Kong, Ziyue Yang, Woan Ting Tay, Ivan Pushkarsky, Kyungsoo Kim, Shan S Parikh, Shreya Udani, Boon Seng Soh, Chen Gao, Linsey Stiles, Orian S Shirihai, Bjorn C Knollmann, Reza Ardehali, Dino Di Carlo, Yibin Wang

Faculty, Staff and Students Publications

No abstract provided.

Macrocephaly And Developmental Delay Caused By Missense Variants In Rab5c, Klaas Koop, Weimin Yuan, Federico Tessadori, Wilmer R Rodriguez-Polanco, Jeremy Grubbs, Bo Zhang, Matt Osmond, Gail Graham, Sarah Sawyer, Erin Conboy, Francesco Vetrini, Kayla Treat, Rafal Płoski, Victor Murcia Pienkowski, Anna Kłosowska, Elizabeth Fieg, Joel Krier, Coralie Mallebranche, Ziegler Alban, Kimberly A Aldinger, Deborah Ritter, Ellen Macnamara, Bonnie Sullivan, John Herriges, Joseph T Alaimo, Catherine Helbig, Colin A Ellis, Clare Van Eyk, Jozef Gecz, Daniel Farrugia, Ikeoluwa Osei-Owusu, Lesley Adès, Marie-Jose Van Den Boogaard, Sabine Fuchs, Jeroen Bakker, Karen Duran, Zachary D Dawson, Anika Lindsey, Huiyan Huang, Dustin Baldridge, Gary A Silverman, Barth D Grant, David Raizen, Undiagnosed Diseases Network, Gijs Van Haaften, Stephen C Pak, Holger Rehmann, Tim Schedl, Peter Van Hasselt

Faculty, Staff and Students Publications

Rab GTPases are important regulators of intracellular vesicular trafficking. RAB5C is a member of the Rab GTPase family that plays an important role in the endocytic pathway, membrane protein recycling and signaling. Here we report on 12 individuals with nine different heterozygous de novo variants in RAB5C. All but one patient with missense variants (n = 9) exhibited macrocephaly, combined with mild-to-moderate developmental delay. Patients with loss of function variants (n = 2) had an apparently more severe clinical phenotype with refractory epilepsy and intellectual disability but a normal head circumference. Four missense variants were investigated experimentally. In vitro biochemical …

“She Had Snatched Their Trophy”: “Lanval,” “Beowulf,” And The Weaver-Cum-Warrior, Margaret Mcfarlane

International Journal of Undergraduate Research and Creative Activities

How was masculinity defined, and for whom, in medieval English epic? Employing Marie de France’s “Lanval” and the anonymous “Beowulf ” as example cases, when examining the social role of gender rather than focus on sexuality as defined by genitalia, these poems flip the script. Wherein titular male-identifying characters swap social responsibilities with female-identifying foils; Beowulf and Lanval become “weaving” humans, while Lanval's lover and Grendel’s Mother take on the “weaponed” roles in order to protect the material existence of their communities. By examining these exchanges, as well as characters that embody the gender role that is expected of them, …

Ekphrasis In Ecocriticism: Auden’S “Musée Des Beaux Arts” And Bruegel’S “Landscape With The Fall Of Icarus”, Chloe N. Young

International Journal of Undergraduate Research and Creative Activities

If ekphrasisis a literary description of a visual work of art, and ecocriticism uses literature to study nature and ecological concerns, how do the two mix? The ekphrastic poem “Musée des Beaux Arts” by W.H. Auden not only expands the understanding of the genre but also broadens the understanding of nature. Auden’s poem is quintessentially ekphrastic, yet it has never been examined in terms of how it is both informed by and informs an eco-critical reading. Auden and Pieter Bruegel, the painter of “Landscape with the Fall of Icarus” upon which Auden based his poem, express nature through the imagery …

Strenuous Exercise Increases The Risk Of Oxidative Stress In Ironman Triathlon Participants, Noelle L. Cutter, Emily Cruz, Frank Cristall Iii, Kristen Lacey

International Journal of Undergraduate Research and Creative Activities

Regular physical activity has been linked to greater overall health. Literature review and studies have also defined regular physical activity as a reducer of life-threatening illnesses such as cardiovascular disease, diabetes and obesity. However, long increments of strenuous exercise can produce oxidative stress and muscle fatigue in the human body. The increase in oxygen consumption during strenuous exercise leads to elevated reactive oxygen species (ROS). Cells continuously produce free radicals and reactive oxygen species as part of metabolic processes in the body. These free radicals are neutralized by an antioxidant defense system in the body consisting of enzymes, such as …

“We’Ll Cook Him Up In A Stew”: Stepmothers And Primogeniture In The Brothers Grimm’S The Juniper Tree, Kymberlin Bush

International Journal of Undergraduate Research and Creative Activities

What larger social concern could the continued popularity of the nineteenth-century cannibal stepmother narrative in twenty-first century crime and news reporting be indicating? In this paper, I compare a fictional episode of cannibalism in the non-canonical Brothers Grimms’ tale, “The Juniper Tree,” with the true story of the 2010 murder and subsequent dismemberment of Zahra Baker in Hickory, North Carolina to consider the larger cultural implications of cannibalistic stepmothers. In doing so I argue that, despite the half-hearted attempt by mainstream animation studios to try to create semi-Feminist adaptations of the canonical fairy tales collected by the Brothers Grimm, Hans …

What's At Stake: Is It A Vampire Or A Virus?, Kaitlin M. Schneider

International Journal of Undergraduate Research and Creative Activities

Vampires have been discussed for millennia, appearing in folklore throughout various cultures. From the Egyptians and the Chinese to the Slavs, there have been numerous iterations of these bloodsucking fiends, but do their characteristics have any basis in fact, perhaps predicated upon misunderstandings of certain diseases?Using medical journals to discern plausible diseases for obscure and typical vampire traits, this paper functions on two levels. On one hand, it offers a repository of medical information for researchers who may want to delve further into the interdisciplinary field of pathology and folklore, especially where vampires of Western culture are concerned. On the …

Analyzing And Designing An Arduino Controlled System To Study The Effect Of Changing Water Levels On Water Flow Through Sediments, Andrea M. Bonetto, Sheiny Tjia-Fleck, Ethan Zeller, Bradley Wheeler

International Journal of Undergraduate Research and Creative Activities

The hyporheic zone is the region of sediment under a stream where water from the stream flows before returning to the stream itself. Many studies focus on steady water flow through this region, however, in natural systems, water levels and water flow rates change due to storms, tides, dams, or melting snow. To investigate flow under unsteady conditions, we built a system that allows us to control the water level and thus the flow rates. We used a pressure sensor that is connected to an Arduino board to measure the water level. The Arduino board uses the measured pressure value …

Gender-Neutral Language In Christian Universities, Adi F. Mcnally

International Journal of Undergraduate Research and Creative Activities

Award for Best Conference Paper2018 Northwest Undergraduate Conference in the HumanitiesThis paper provides brief summation of the methods transphobia are embodied through language and what the logical, moral, and business implications would be for a Christian University. In this paper, Adi McNally (who uses they/them pronouns) explores whether there is both scientific and theological weight behind transphobic and gendered language choices. They connect the Sapir-Whorf hypothesis of linguistic relativity to discussions around epicene pronouns and English grammatical development. Their argument explores writings from Doctors Lawrence Mayer and Paul McHugh, and its impact on traditionally conservative Christian thought. Further, they discuss …

The Social Epistemology Of Anthropology: Insights From Judgment Aggregation, Dagan Douglas

International Journal of Undergraduate Research and Creative Activities

Anthropological writings have, at times, been vague in the approach used to gather evidence of cultural and social beliefs of the peoples studied, and the method of representing the data to the reading public. This paper employs the theory of judgment aggregation in critiquing anthropological theory and practice. It will be structured in three parts: first, I will present the theory of judgment aggregation as constructed by Christian List and Philip Pettit; second, I will sketch some epistemological methods used by anthropologists, and assess their attitude toward the notions of judgment aggregation and group agency; and finally, I will apply …

Belief Revision In The Context Of Hume’S Treatise And Contemporary Psychology, Sarah Paquette

International Journal of Undergraduate Research and Creative Activities

This paper examines the emotional and social motivations of belief and belief correction. As beliefs motivate one’s actions, one must examine how one revises an erroneous or harmful belief and what methodology one can employ in order to best facilitate this revision, resulting in more conscientious action. This paper examines belief formation and revision in the context of David Hume’s 1739-1740 work A Treatise of Human Nature, with particular attention to not only Hume’s account of belief and belief revision, but also the interaction of passions, the mechanism of sympathy, reason, and probability judgments. It is hypothesized Hume’s theory of …

Applications Of Medico-Legal Entomology: Using Insects For Forensic And Environmental Investigations, Denise Gemmellaro

Sustainability Seminar Series

Forensic entomology is the application of entomology (the study of insects and arthropods) to forensic investigations. Medico-legal entomology focuses on those groups of insects that are attracted to decomposing organic matter. Dr. Gemmellaro’s work is mainly focused on medico-legal entomology. Once a dead body is exposed to the elements, insects will shortly locate the body and will colonize it by laying eggs on it; one of the major groups of colonizers is the true fly family of blow flies (Diptera: Calliphoridae). Blow fly females need a decomposing body to lay their eggs; the eggs will hatch into maggots and the …

The Big Sky Five: A Statewide Effort To Increase Teacher Preparedness For Inclusive Classrooms, Trent Atkins, Estee Aiken, Jayne Downey

Journal of Educational Research and Innovation

The purpose of this paper is to describe a state-wide process used to determine which Teaching Works High Leverage Practices (Ball, 2016) pre-service teachers could be expected to implement at a proficient level by the completion of their preparation program (Initial HLPs), followed by two sets of high leverage practices novice teachers could master during their induction years (Induction and Expert HLPs) (Ball & Forzani, 2011; McLeskey & Brownell, 2015). Data were collected from a wide variety of stakeholders, including K-12 teachers, administrators, and educator preparation program faculty from across the state (N=203). Findings identified five High Leverage Practices that …

Land Education And Young People Working Toward Salamander: Collective Well-Being In Response To Bioindicators Of Socioenvironmental Justice, Rachael Arens, Ricardo Martinez

Democracy & Education

Our planet is facing many environmental challenges, including climate change, loss of biodiversity and habitat, and pollution, while many of our populations are also experiencing marginalization due to poverty, race, gender, language, ability, and environmental injustices. Environmental hazards and policies often impact those in society who are most at-risk, creating a need for an environmental education (EE) movement that encourages students to challenge and regain control of a system that impacts them. Teachers can implement a reflection tool known as the SALAMANDER Collective Well-Being in Response to Bioindicators of Socioenvironmental Justice Framework to prompt students and other educators to place …

Concerned But Confused: University Students' Knowledge And Perceptions Of Climate Change, And How They Plan To Address It In Their Future Personal And Professional Lives., Miranda Kistner, Jeremy Jiménez

The SUNY Journal of the Scholarship of Engagement: JoSE

This article explores university students’ knowledge and concern level towards climate change, as well as potential roles they see themselves playing as teachers in a world increasingly affected by its impacts. A survey of 135 university students was conducted at SUNY Cortland, a medium-size state university in Upstate New York. Results show that these university students (among them pre-service teachers) are highly concerned about the potential impacts of climate change, especially for future generations. While they demonstrate some accurate knowledge of climate change, many hold many misconceptions about its causes and consequences. In articulating how they can or do respond …

Understanding Functional Benefits Of Isoleucine And Arginine On Poultry Performance And Health., Roshan Adhikari, Jason T. Lee, Keith Haydon

Proceedings of the Arkansas Nutrition Conference

Poultry industry is rapidly moving towards utilizing the best ingredients to precisely feed the birds for better performance, welfare, health, and profitability. One of the practices that evolved over time with research is better optimization of amino acid utilization in the diets thus changing the crude protein landscape. Historically, if we compare the modern diets to diets from 1980, significant changes are visible in the use of unbound or crystalline amino acids leading to reduced levels of CP and reduced unutilized nitrogen in the diets. Multiple feed-grade amino acids are available in a cost-effective manner in poultry diets. Multiple research …

Measuring Circularity: The Gordian Knot Of The 21st Century, Arjen Wierikx, Pascal Ravesteijn, Néomie Raassens, Alex Alblas

Communications of the IIMA

Organizations are currently facing substantial challenges regarding becoming circular by 2050 – also referred to as Circular Economy (CE). Subsequently, increasing complexity on all organizational levels creates uncertainty about respective organizational and technological capabilities and adequate strategies to develop these capabilities. Organizations are struggling in picking up the CE ambitions and answering the what’s in it for me question. Scholars are developing models and frameworks to enable organizations to measure CE performance. Over 125 assessment methods are available for micro level assessment – measuring up to 365 different metrics. Moreover, extant literature is available presenting barriers and opportunities for CE …

Title: The Truth Behind A Guardian Ad Litem, Klarissa Stovall

Master of Arts in Criminal Justice Leadership

The role of a guardian ad litem is at the forefront when acknowledging the significance of the role in its entirety when considering the safety and wellbeing of a child who is a victim of abuse or neglect. Also focusing on the supportive topics including adequate training, effective communication, and safety is equally important when discussing the role of a guardian ad litem. Furthermore, being able to acknowledge the role of a guardian ad litem is extremely helpful when remembering how vital they are to the future of a child, specifically when involved in child protective services or family law. …

The Effects Of Mindfulness On Depression In Dialysis Patients, Nakeia Saddler

Dissertations

Abstract

Problem: Depression is a prevailing global health issue and a typical complication of dialysis patients. This quality improvement project's purpose was to evaluate mindfulness on depression in dialysis patients, aged 18-93, who are on dialysis and participated in a mindfulness program over three months.

Methods: A descriptive, prospective, and retrospective design was used to assess depression pre- and post-implementation of a mindfulness telephone line over three months. A convenience sample of twenty adults aged 18-83 who use this hemodialysis center on Monday, Wednesday, and Friday was utilized. The Iowa Model is the framework selected to guide the implementation of …

Trna Dysregulation In Neurodevelopmental And Neurodegenerative Diseases., Robert W. Burgess, Erik Storkebaum

Faculty Research 2023

Transfer RNAs (tRNAs) decode messenger RNA codons to peptides at the ribosome. The nuclear genome contains many tRNA genes for each amino acid and even each anticodon. Recent evidence indicates that expression of these tRNAs in neurons is regulated, and they are not functionally redundant. When specific tRNA genes are nonfunctional, this results in an imbalance between codon demand and tRNA availability. Furthermore, tRNAs are spliced, processed, and posttranscriptionally modified. Defects in these processes lead to neurological disorders. Finally, mutations in the aminoacyl tRNA synthetases (aaRSs) also lead to disease. Recessive mutations in several aaRSs cause syndromic disorders, while dominant …

The Family And The Nation: The Centrality Of Gender Politics In The Rise Of European Illiberalism, Julia E. Hall

Claremont-UC Undergraduate Research Conference on the European Union

This paper analyzes how illiberal far-right parties employ discourses of traditional family values to advocate a range of anti-feminist, anti-queer, and anti-sexual education stances that have become critical in European national politics. Illiberal politicians use the concept of "traditional family" to reassert heteronormative ideas of gender and sexuality that advance their majoritarian, nationalist, and anti-pluralist platforms while infringing on the rights and freedoms of gender and sexual minorities. I explore three realms where this family-centered rhetoric presents itself in policy and political movements—gender roles and reproduction, LGBTQ+ rights, and sexual education—and analyze relevant actors, movements, and policies demonstrating the central …

Assessing The Toxicity Of Selected Pesticides To Trichogramma Ostriniae (Hymenoptera: Trichogrammatidae) Pupae As A First Step In The Development Of A Potential Novel Deployment Programme, Jeffrey D. Cluever, Clint W. Beiermann, Nevin C. Lawrence, Jeff Bradshaw

Panhandle Research and Extension Center

Trichogramma spp. have been used or have been proposed for use in biological control programmes of lepidopteran pests, including the European corn borer, Ostrinia nubilalis, the cotton bollworm, Helicoverpa armigera, and the spruce budworm, Choristoneura fumiferana. Releases are typically made by placing cards with parasitised eggs at set points in the field. However, this method can be cost-prohibitive due to its laborious nature. As a result, labour-saving mechanised release programmes have been developed, including distribution by spray equipment. However, few have investigated applying Trichogramma with a standard pesticide application (i.e. ‘tank mix’). As a first step to …

Uncle Sam On The Road: Managing The Intricacies Of A Government Documents Collection Move, Lauire Aycock, Michelle E. Colquitt, Amanda Mcleod

Presentations

No abstract provided.

The Rider (2023-10-16), Natalie Lapsley

The Rider Archives

Vol.9 No.8