Digital Commons Network^™

Janet Schrunk Ericksen: An Unplanned Champion Of Liberal Arts, Communications And Marketing

Campus News Archive

No abstract provided.

Deep Learning-Based Automatic Stereology For High- And Low-Magnification Images, Hunter Morera

USF Tampa Graduate Theses and Dissertations

Quantification of the true number of stained cells in specific brain regions is an important metric in many fields of biomedical research involving cell degeneration, cytotoxicology, cellular inflammation, and drug development for a wide range of neurological disorders and mental illnesses. Unbiased stereology is the current state-of-the-art method for collecting the cell count data from tissue sections. These studies require trained experts to manually focus through a z-stack of microscopy images and count (click) on a hundred or more cells per case, making this approach time consuming (~1 hour per case) and prone to human error (i.e., inter-rater variability). Thus, …

Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel 3 Promotes Hcc Development In A Female-Biased Manner, Yueqi Zhang, Xinhui Liu, Kairui Sun, Yue Luo, Jack Yang, Aimin Li, Matti Kiupel, Stefanie Fenske, Martin Biel, Qing-Sheng Mi, Hongbing Wang, Hua Xiao

Dermatology Articles

Sex differences in hepatocellular carcinoma (HCC) development are regulated by sex and non-sex chromosomes, sex hormones, and environmental factors. We previously reported that Ncoa5(+/-) mice develop HCC in a male-biased manner. Here we show that NCOA5 expression is reduced in male patient HCCs while the expression of an NCOA5-interacting tumor suppressor, TIP30, is lower in female HCCs. Tip30 heterozygous deletion does not change HCC incidence in Ncoa5(+/-) male mice but dramatically increases HCC incidence in Ncoa5(+/-) female mice, accompanied by hepatic hyperpolarization-activated cyclic nucleotide-gated cation channel 3 (HCN3) overexpression. HCN3 overexpression cooperates with MYC to promote mouse HCC development, whereas …

Method For The Treatment Of Malignancies, Richard Heller, Melinda Lee Lucas

USF Patents

A method of treating cancerous tumors is presented herein. The method includes injecting an effective dose of a plasmid encoded for IL-12, B7-1 or IL-15 into a cancerous tumor and subsequently administering at least one high voltage, short duration pulse to the tumor. The electroporation pulses may be administered at least 700V/cm for a duration of less than 1 millisecond. The intratumor treatments with electroporation may be administered in at least a two-treatment protocol with the time between treatments being about 7 days. The intratumor treatments with electroporation may be administered in a three-treatment protocol with a time of four …

Sporozoite Cryopreservation Compositions And Methods, John H. Adams, Alison Elizabeth Roth

USF Patents

Described herein are compositions and methods to cryopreserve sporozoites. In some aspects, the method can include the step of placing harvested salivary glands containing sporozoites into an insect-based medium.

Automated Stereology For Determining Tissue Characteristics, Peter Randolph Mouton, Hady Ahmady Phoulady, Dmitry Goldgof, Lawrence O. Hall

USF Patents

Systems and methods for automated stereology are provided. A method can include providing an imager for capturing a Z-stack of images of a three-dimensional (3D) object; constructing extended depth of field (EDF) images from the Z-stack of images; performing a segmentation method on the EDF images including estimating a Gaussian Mixture Model (GMM), performing morphological operations, performing watershed segmentation, constructing Voronoi diagrams and performing boundary smoothing; and determining one or more stereology parameters such as number of cells in a region.

Analyzing Prominent Genes In Acute Lymphocytic Leukemia (All), Shima Z. Omar

Honors College Theses

Acute lymphocytic leukemia (ALL) is the most common type of childhood cancer. Leukemia is a type of cancer that involves the bone marrow and blood. This research study examined prominent genes in the disease. Two groups of genes, tumor suppressor and cell differentiation, were compared using statistical analysis to compare their binding potential and epigenetic potential. It is most likely that I failed to detect significant differences either because these genes’ function in the disease etiology is not strongly contexed to changes in expression, or that the magnitude of the differences were too slight to be detected with these methods. …

Exploring The Dynamic Reading Of Environment Towards A Multidimensional Legibility, Putri Mahsa Gantari, Ferro Yudistira

ARSNET

This study investigates the understanding of legibility, defined as the coherency of built environment features. Legibility enables production of mental image that helps individuals with their spatial navigation. The current discussion positions legibility as an objective aspect in the process of making sense of the environment. The study argues that such a process has dynamics that reflect individuals' subjectivity, therefore further study is important to reconcile the objective and subjective reading of legibility. This research qualitatively investigates legibility using a case study of an indoor environment of a shopping mall in East Jakarta. The analysis was conducted based on the …

Iranian Music, Silence, And The Representation Of The Traditional Masculine Figure Of The Pahlavan: A Case Study Of "Dash Akol" (1971), Kamyar Salavati

Regards

The Persian term pahlavan represents an archetypal character of a strong man who is generous, uncorrupted, and humble in the face of weakness. This paper will focus on sonic aspects of the pahlavan by zooming in on one of Masoud Kimiai’s films, Dash Akol (1971), which is based on a story of the same name by Sadegh Hedayat. First, I will concentrate on how the movie links heroic masculinity to the Persian classical music mode Chahargah and the instrument tombak-e zurkhaneh, and contrasts it with the tragic and romantic associations of Dashti, another Persian classical mode, representing another, …

Multiple Light Signaling Pathways Control Solar Tracking In Sunflowers, Christopher J. Brooks, Hagop S. Atamian, Stacey L. Harmer

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Sunflowers are famous for their ability to track the sun throughout the day and then reorient at night to face east the following morning. This occurs by differential growth patterns, with the east sides of stems growing more during the day and the west sides of stems growing more at night. This process, termed heliotropism, is generally believed to be a specialized form of phototropism; however, the underlying mechanism is unknown. To better understand heliotropism, we compared gene expression patterns in plants undergoing phototropism in a controlled environment and in plants initiating and maintaining heliotropic growth in the field. We …

Developing A Winning Proposal, Rene Drumm

Human Subject Research Archive

Powerpoint presentation (including audio) developed to help people to prepare a "winning" presentation proposal for AHSRA conference.

Metal-Organic Frameworks As Photocatalysts In Energetic And Environmental Applications, Eli̇f Özcan, Zeli̇ha Mermer, Yunus Zorlu

Turkish Journal of Chemistry

Metal-organic frameworks (MOFs) are an exciting new class of porous materials with great potential for photocatalytic applications in the environmental and energy sectors. MOFs provide significant advantages over more traditional materials when used as photocatalysts due to their high surface area, adaptable topologies, and functional ability. In this article, we summarize current developments in the use of MOFs as photocatalysts for a variety of applications, such as CO2 reduction, water splitting, pollutant degradation, and hydrogen production. We discuss the fundamental properties of MOFs that make them ideal for photocatalytic applications, as well as strategies for improving their performance. The opportunities …

Comparatively Sonophotochemical And Photochemical Studies Of Phthalocyanines With Cationic Substituents On Nonperipheral Positions, Mukaddes Özçeşmeci̇, Ceren Can Karanlik, Ali̇ Erdoğmuş, Esi̇n Hamuryudan

Turkish Journal of Chemistry

The term sonophotodynamic therapy (SPDT) refers to a combination of sonodynamic therapy (SDT) and photodynamic therapy (PDT), in which the efficacy of the treatment is boosted by utilizing the proper amount of a sensitizer that is responsive to both light and ultrasound. Although it has been proven in photophysicochemical studies that SPDT enhances singlet oxygen production, related studies in the literature are very limited. Considering this situation, this study aims to investigate the efficacy of synthesized phthalocyanines in terms of PDT and SPDT. The singlet oxygen quantum values calculated as 0.13 for 5, 0.44 for 6, and 0.61 for 7 …

Synthesis Of Alnustone-Like Diarylpentanoids Via A 4 + 1 Strategy And Assessment Of Their Potential Anticancer Activity, Nesli̇han Çelebi̇oğlu, Özlem Özdemi̇r Tozlu, Hasan Türkez, Hasan Seçen

Turkish Journal of Chemistry

Twelve compounds with a 1,5-diaryl-1-penten-3-one structure were synthesized and their cytotoxic activities were evaluated. The 1,5-diaryl-1-penten-3-one compounds were obtained via in situ enaminations of 4-phenyl-2-butanone and 4-(4-hydroxyphenyl)-2- butanone in the presence of pyrrolidine-AcOH, followed by condensation with six different benzaldehydes. The synthesized compounds were tested for their cytotoxic activity against human glioblastoma (U87-MG), breast (MCF-7), and prostate (PC-3) cancer cell lines. Some of the novel compounds exhibited remarkable cytotoxic action, especially against MCF-7 cancer cells.

Synthesis, Characterization, And Photophysical And Fluorescence Sensor Behaviors Of A New Water-Soluble Double-Bridged Naphthalene Diimide Appended Cyclotriphosphazene, Süreyya Oğuz Tümay, Serkan Yeşi̇lot

Turkish Journal of Chemistry

A new water-soluble template of double-bridged naphthalene diimide appended cyclotriphosphazene was prepared, and its photophysical and sensor behaviors were evaluated. The characterization of novel double-bridged naphthalene diimide appended cyclotriphosphazene (6) was carried out by NMR (1 H, 13C, 31P) and mass spectroscopies. The photophysical behaviors of compound 6 were evaluated by UV-Vis absorption and fluorescence spectroscopies in various solvent systems and different concentrations. As an application for usability of the obtained water-soluble template in different applications, the fluorescence sensor property of compound 6 was investigated in the presence of many different competing species (organic acids, saccharides, nitroaromatic compounds, anions, and …

Osc-Co2: Coattention And Cosegmentation Framework For Plant State Change With Multiple Features, Rubi Quiñones, Ashok Samal, Sruti Das Choudhury, Francisco Muñoz-Arriola

School of Computing: Faculty Publications

Cosegmentation and coattention are extensions of traditional segmentation methods aimed at detecting a common object (or objects) in a group of images. Current cosegmentation and coattention methods are ineffective for objects, such as plants, that change their morphological state while being captured in different modalities and views. The Object State Change using Coattention-Cosegmentation (OSC-CO²) is an end-to-end unsupervised deep-learning framework that enhances traditional segmentation techniques, processing, analyzing, selecting, and combining suitable segmentation results that may contain most of our target object’s pixels, and then displaying a final segmented image. The framework leverages coattention-based convolutional neural networks (CNNs) and …

Effects Of A Major Hurricane On Dynamics, Structure, And Composition Of Mississippi River Delta Forests, Lance C. Umlang

LSU Doctoral Dissertations

Tropical cyclones recurrently influence coastal forests worldwide. Tree survival (resistance) and post-cyclone recruitment (resilience) can vary with cyclone intensity, producing differences in composition, arboreal structure, and dynamics among affected forests. Studies of tropical cyclone wind effects on coastal forests typically emphasize damage more than post-cyclone responses. We hypothesized that intense cyclones might produce large, stratum-dependent effects that prevent affected forests from returning to pre-storm conditions. We explored direct effects of major Hurricane Katrina and post-hurricane changes in oak-dominated bottomland and cypress/tupelo-dominated swamp forests within the inactive portion of the Mississippi River deltaic plain. Overall mortality was high (14-25%) but concentrated …

Design, Synthesis And Post Functionalization Of Bodipy Dyes For Use As Chemo Sensors., Caroline Njeri Ndung'u

LSU Doctoral Dissertations

An overview of BODIPYs history, basic structure, electronic properties is described. Additionally, their attribute of tenability in their photophysical and electronic properties has been discussed. Lastly, their application in the biomedical field as bio imaging, labeling, chemo sensors and photosensitizers are also discussed. In Chapter 2, a library of meso- Pyridyl and meso pyridinium BODIPY dyes was designed, synthesis and comparison on their photophysical, electrochemical and cytotoxic studies done. From this study chlorine atoms at the 2, 6 positions was shown to enhance their relative fluorescence quantum yields in different organic solvents and water. In chapter 3, 8(meso)-pyridyl-BODIPYs with a …

Effects Of Fertigation Versus Palletized Fertilizer On Height And Caliper Growth In Oaks, Zachary M. Davis

LSU Master's Theses

The Covid-19 pandemic and ensuing lockdowns led to an increase in revenue and production for green industry products in early 2020. In Study 1. an evaluation of fertigation (liquid feed, quick release) and controlled release fertilizers (CRFs, slow release) were applied to container-grown (7 gallon) live oak (Quercus virginiana) and Nutall oak (Quercus nuttallii) trees (100% Liquid feed, 0% CRF, 67% Liquid feed, 33% CRF, 33% Liquid feed, 67% CRF, 100% Liquid feed, 0% CRF). Live oak trees fertilized with CRFs had increased stem calipers (>30%). Nuttall stem caliper and height were significantly increased by …

Characteristics Of Post Hoc Subgroup Analyses Of Oncology Clinical Trials: A Systematic Review, Jawad Alrawabdeh, Marah Alzu'bi, Muntaser Alzyoud, Nada Odeh, Yazan Hamadneh, Hira Mian, Ghulam Rehman Mohyuddin, Amar H Kelkar, Aaron M Goodman, Rajshekhar Chakraborty, David A Russler-Germain, Nikita Mehra, Diva Baggio, Edward R Scheffer Cliff, Samer Al Hadidi

2020-Current year OA Pubs

BACKGROUND: Subgroup analyses in clinical trials assess intervention effects on specific patient subgroups, ensuring generalizability. However, they are usually only able to generate hypotheses rather than definitive conclusions. This study examined the prevalence and characteristics of post hoc subgroup analysis in oncology.

METHODS: We systematically reviewed published subgroup analyses from 2000 to 2022. We included articles presenting secondary, post hoc, or subgroup analyses of interventional clinical trials in oncology, cancer survivorship, or cancer screening, published separately from the original clinical trial publication. We collected cancer type, year of publication, where and how subgroup analyses were reported, and funding.

RESULTS: Out …

Mycobacterium Tuberculosis Carrying The Rifampicin Drug-Resistance-Conferring Rpob Mutation H445y Is Associated With Suppressed Immunity Through Type I Interferons, Suhas Bobba, Nicole C Howard, Shibali Das, Mushtaq Ahmed, Linrui Tang, Shyamala Thirunavukkarasu, Michelle H Larsen, Barun Mathema, Maziar Divangahi, Shabaana A Khader

2020-Current year OA Pubs

This study highlights the impact of specific rifampicin-resistance-conferring mutations on the host immune response to

Molecular Docking And Dynamics Identify Potential Drugs To Be Repurposed As Sars-Cov-2 Inhibitors, Mohammed Muzaffar-Ur-Rehman, Chougule K. Suryakant, Ala Chandu, Banoth K. Kumar, Renuka P. Joshi, Snehal R. Jadav, Murugesan Sankaranarayanan, Seshadri S. Vasan

Research outputs 2022 to 2026

The novel coronavirus disease 19 (COVID-19) has resulted in an estimated 20 million excess deaths and the recent resurgence of COVID-19 in China is predicted to result in up to 1 million deaths over the next few months. With vaccines being ineffective in the case of immunocompromised patients, it is important to continue our quest for safe, effective and affordable drugs that will be available to all countries. Drug repurposing is one of the strategies being explored in this context. Recently, out of the 7817 drugs approved worldwide, 214 candidates were systematically down-selected using a combination of 11 filters including …

Synthesis Of New Imine-/Amine-Bearing Imidazo[1,2-A]Pyrimidine Derivatives And Screening Of Their Cytotoxic Activity, Tuğba Güngör, Hazal Nazlican Atalay, Yakup Berkay Yilmaz, Tuğba Tümer, Mehmet Ay

Turkish Journal of Chemistry

Imidazo[1,2-a]pyrimidine derivatives bearing imine groups (3a-e) were successfully synthesized in moderate to good yields using microwave-assisted heating. Corresponding amine derivatives (4a-e) were also obtained by the reduction reaction of the imine derivatives (3a-e). All synthesized products were characterized by FT-IR, 1 H NMR, 13C NMR, and LC-MS spectroscopic techniques. In silico ADMET, Lipinski, and drug-likeness studies of the compounds were conducted and all were found to be suitable drug candidates. The cytotoxicity of the potential drug molecules was screened against the breast cancer cell lines MCF-7 and MDA-MB-231 and the healthy model HUVEC by the sulforhodamine B method. According to …

Water-Soluble Phthalocyanine Photosensitizers For Photodynamic Therapy, İpek Ömeroğlu, Mahmut Durmuş

Turkish Journal of Chemistry

Photodynamic therapy (PDT) is based on a photochemical reaction that is started when a photosensitizing process is activated by the light and results in the death of tumor cells. Solubility is crucial in PDT applications to investigate the physical and chemical characteristics of phthalocyanines, but, unfortunately, most phthalocyanines show limited solubility especially in water. To increase the solubility of phthalocyanines in polar solvents and water, ionic groups such as -SO3 - , -NR3 +, -COO- , and nonionic groups such as poly-oxy chains are frequently added to the peripheral or nonperipheral positions of the phthalocyanine framework. Since water-solubility and NIR-absorbing …

Innovative Polymer Engineering For The Investigation Of Electrochemical Properties And Biosensing Ability, Sila Can Osmanoğullari, Sani̇ye Söylemez, Oğuzhan Karakurt, Şeri̇fe Özdemi̇r Hacioğlu, Ali̇ Çirpan, Levent Kami̇l Toppare

Turkish Journal of Chemistry

Subtle engineering for the generation of a biosensor from a conjugated polymer with the inclusion of fluorine-substituted benzothiadiazole and indole moieties is reported. The engineering includes the electrochemical copolymerization of the indole-6-carboxylic acid (M1) and 5-fluoro-4,7-bis(4-hexylthiophen-2-yl)benzo[c][1,2,5]thiadiazole (M2) on the indium tin oxide and graphite electrode surfaces for the investigation of both their electrochemical properties and biosensing abilities with their copolymer counterparts. The intermediates and final conjugated polymers, Poly(M1) [P-In6C], Poly(M2) [P-FBTz], and copoly(M1 and M2) [P-In6CFBTz], were entirely characterized by 1 H NMR, 13C NMR, CV, UV-Vis-NIR spectrophotometry, and SEM techniques. HOMO energy levels of electrochemically obtained polymers were calculated …

Anthocyanins: Molecular Aspects On Their Neuroprotective Activity, César A Zaa, Álvaro J Marcelo, Zhiqiang An, José L Medina-Franco, Marco A Velasco-Velázquez

Faculty, Staff and Student Publications

Anthocyanins are a type of flavonoids that give plants and fruits their vibrant colors. They are known for their potent antioxidant properties and have been linked to various health benefits. Upon consumption, anthocyanins are quickly absorbed and can penetrate the blood-brain barrier (BBB). Research based on population studies suggests that including anthocyanin-rich sources in the diet lower the risk of neurodegenerative diseases. Anthocyanins exhibit neuroprotective effects that could potentially alleviate symptoms associated with such diseases. In this review, we compiled and discussed a large body of evidence supporting the neuroprotective role of anthocyanins. Our examination encompasses human studies, animal models, …

Dark Tourism Di Hashima Pasca Penobatan Dalam World Heritage Unesco, Jemima Alma Sabila, Didit Dwi Subagio

Multikultura

Hashima (Gunkanjima) berhasil tercatat sebagai situs warisan dunia UNESCO pada tahun 2015. Pencatatan pulau ini sempat mendapat penolakan keras dari Korea Selatan karena Jepang tidak mencantumkan sejarah lengkap yang menyangkut kerja paksa warga Korea Selatan dan Tiongkok. Berdasarkan data pemerintah Nagasaki, Hashima mengalami lonjakan pengunjung lebih dari seratus ribu wisatawan setelah namanya tercatat dalam situs warisan dunia UNESCO. Sebelumnya, Hashima hanya dikenal akan dark tourism-nya sebagai pulau hantu, tetapi kini semakin dilirik wisatawan dengan imej yang berbeda setelah pencatatan UNESCO dan pembangunan lokasi wisata penunjang seperti Gunkanjima Digital Museum. Penelitian ini membahas mengenai dark tourism Hashima dan lokasi terkaitnya serta …

Kewarganegaraan Inklusif: Menempatkan Model Budaya Disabilitas Dalam Teori Multikultural Liberal Will Kymlicka, Hanandhia Lindsy Rustam, Lg. Saraswati Putri

Multikultura

Tulisan ini bertujuan untuk menggambarkan cultural model of disability atau model budaya disabilitas dalam teori multikultural liberal Will Kymlicka. Status kewarganegaraan disabilitas seringkali masih diturunkan menjadi kewarganegaraan pasif atau parsial yang patut dikasihani dan mendapat perhatian paternalistik. Kemunculan advokasi disabilitas sebagai hak kelompok dan bukan hak individu baru-baru ini menuntut kita untuk mengevaluasi secara lebih menyeluruh konsepsi disabilitas sebagai sebuah kelompok non-etnis namun bersifat budaya yang menegosiasikan tempat mereka di wilayah negara. Model budaya disabilitas inilah yang sejalan dengan tujuan teori multikultural liberal Will Kymlicka yang menyatakan bahwa masyarakat yang beragam membutuhkan lebih dari sekedar akses yang setara dan hak-hak …

Longitudinal Associations Of Dietary Fiber Intake With Glycated Hemoglobin And Estimated Insulin Sensitivity In Adults With And Without Type 1 Diabetes, Arpita Basu, Andrew Hooyman, Leigh Ann Richardson, Amy C. Alman, Janet K. Snell-Bergeon

Physical Therapy Faculty Articles and Research

Dietary fiber, an essential bioactive compound in plant-based diets, is of public health concern based on habitual low intakes in the general population. Not much data are available on how habitual dietary fiber is associated with glycemic control in type 1 diabetes (T1D) as well as in prediabetes and normoglycemic adults. To address this gap, we conducted a six-year longitudinal analysis of an original cohort in adults with and without T1D (n = 1255; T1D: n = 563; non-diabetes mellitus (non-DM): n = 692). Dietary data were collected from a validated food frequency questionnaire, biochemical measures were obtained after an …

Eksplorasi Konstruksi Identitas Guru Sains Melalui Berbagai Konteks Pengalaman Hidup, Ari Dhinansah Herdhiyani, Endang Purwaningsih, Arif Hidayat

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Identity is the construction of interpretations of life experiences in certain contexts resulting in self-understanding. This research with a single case study design aims to explore the identity of science teachers in various contexts of Figured Worlds. The research participant is a science teacher named Yuni who has a background in Physics Education. Data were collected through two semi-structured interviews. The results revealed how Yuni interpreted science-related life experiences in Figured Worlds to construct her identity. The researcher concluded that although throughout Yuni's experience she was not interested in becoming a teacher, she was able to become an outstanding teacher …