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Articles 5161 - 5190 of 35247
Full-Text Articles in Entire DC Network
Adenoid Ameloblastoma With Dentinoid, Eric Silver Dmd, Md, Stephen Roth Dds, Lydia Lam Dds, John Fantasia Dds, Steve Yusupov Dds, Md
Adenoid Ameloblastoma With Dentinoid, Eric Silver Dmd, Md, Stephen Roth Dds, Lydia Lam Dds, John Fantasia Dds, Steve Yusupov Dds, Md
The New York State Dental Journal
Adenoid ameloblastoma with dentinoid (AAD) is a rare benign neoplasm of odontogenic epithelium, with under 50 cases having been reported in the literature. AAD shares histopathological characteristics with both ameloblastomas and adenomatoid odontogenic tumors. They are unique because of dentinoid deposition without enamel. We present a case of AAD in the maxilla of a 13 year old. The patient was treated with left infrastructure maxillectomy and left partial infratemporal fossa dissection. This case reports on an extremely rare disease process in an uncommon location in a pediatric patient.
Geneseo Authors Celebration 2023, Milne Library
Geneseo Authors Celebration 2023, Milne Library
Geneseo Authors Celebration
No abstract provided.
Clinical Efficacy Of Onc201 In H3k27m-Mutant Diffuse Midline Gliomas Is Driven By Disruption Of Integrated Metabolic And Epigenetic Pathways, Minesh Mehta, Matthew Hall, Doured Daghistani, Yazmin Odia
Clinical Efficacy Of Onc201 In H3k27m-Mutant Diffuse Midline Gliomas Is Driven By Disruption Of Integrated Metabolic And Epigenetic Pathways, Minesh Mehta, Matthew Hall, Doured Daghistani, Yazmin Odia
All Publications
Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this finding remains unknown. We assessed clinical outcomes, tumor sequencing, and tissue/cerebrospinal fluid (CSF) correlate samples from patients treated in two completed multisite clinical studies. Patients treated with ONC201 following initial radiation but prior to recurrence demonstrated a median overall survival of 21.7 months, whereas those treated after recurrence had a median overall survival of 9.3 months. Radiographic response was associated with increased expression of key tricarboxylic acid cycle-related genes in baseline tumor sequencing. ONC201 treatment …
Examining Potential Modifiers Of Human Skin And Plasma Carotenoid Responses In A Randomized Trial Of A Carotenoid-Containing Juice Intervention, Stephanie B Jilcott Pitts, Qiang Wu, Nancy E Moran, Melissa N Laska, Lisa Harnack
Examining Potential Modifiers Of Human Skin And Plasma Carotenoid Responses In A Randomized Trial Of A Carotenoid-Containing Juice Intervention, Stephanie B Jilcott Pitts, Qiang Wu, Nancy E Moran, Melissa N Laska, Lisa Harnack
Children’s Nutrition Research Center Staff Publications
Background: Skin carotenoid measurements are emerging as a valid and reliable indicator of fruit and vegetable intake and carotenoid intake. However, little is known about the extent to which skin carotenoid responsivity to dietary changes differs based on demographic and physiologic characteristics.
Objectives: This study examined potential effect modifiers of skin carotenoid and plasma carotenoid responses to a carotenoid-rich juice intervention.
Methods: We leveraged data from 2 arms of a 3-site randomized controlled trial of a carotenoid-containing juice intervention (moderate dose = 6 ounces juice, 4 mg total carotenoids/d, high dose = 12 ounces juice, 8 mg total carotenoids/d) (n …
N Y State Dent J November 2023
N Y State Dent J November 2023
The New York State Dental Journal
In the November 2023 issue, the reader will find the following feature articles:
- Verruciform Xanthoma
- Use of a 3D Intraoral Scanner for Prosthetic Rehabilitation of Cocaine-Induced Oronasal Fistula
- Adenoid Ameloblastoma with Dentinoid
This issue includes regular columns with regional news impacting the New York membership including: editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.
Tennessee Farm Bureau News - November 2023, Tennessee Farm Bureau Federation
Tennessee Farm Bureau News - November 2023, Tennessee Farm Bureau Federation
Tennessee Farm Bureau News
No abstract provided.
Contaminated Bone Grafts And Tuberculosis In Three Spine Surgery Patients: A Case Series, Mustafa Naveed, Tiffany Ruan, Vishakha Sharma, Hon Vien
Contaminated Bone Grafts And Tuberculosis In Three Spine Surgery Patients: A Case Series, Mustafa Naveed, Tiffany Ruan, Vishakha Sharma, Hon Vien
Student Publications
Tuberculosis (TB) is a global health issue affecting millions of people every year. Previous articles displayed cases of TB resulting from contaminated bone grafts used in spinal surgeries. However, deeper understanding about the serious health consequences for patients affected by TB-infected bone grafts is lacking. Here, we discuss three unique patients who contracted TB after undergoing lumbar spinal surgery. We describe three patient cases in which individuals initially presented with back pain, underwent required lumbar spinal fusion surgery with bone graft implants, and, afterwards, contracted TB. All patients were given RIPE therapy, had additional surgery to remove the faulty hardware, …
Examining The Externalities Of Highway Capacity Expansions In California: An Analysis Of Land Use And Land Cover (Lulc) Using Remote Sensing Technology, Serena E. Alexander, Bo Yang, Owen Hussey, Derek Hicks
Examining The Externalities Of Highway Capacity Expansions In California: An Analysis Of Land Use And Land Cover (Lulc) Using Remote Sensing Technology, Serena E. Alexander, Bo Yang, Owen Hussey, Derek Hicks
Mineta Transportation Institute
There are over 590,000 bridges dispersed across the roadway network that stretches across the United States alone. Each bridge with a length of 20 feet or greater must be inspected at least once every 24 months, according to the Federal Highway Act (FHWA) of 1968. This research developed an artificial intelligence (AI)-based framework for bridge and road inspection using drones with multiple sensors collecting capabilities. It is not sufficient to conduct inspections of bridges and roads using cameras alone, so the research team utilized an infrared (IR) camera along with a high-resolution optical camera. In many instances, the IR camera …
The Association Between Total And Types Of Dietary Protein Intake And Prevelence Of Impaired Fasting Glucose And Type 2 Diabetes, Afra Salah Alsammach
The Association Between Total And Types Of Dietary Protein Intake And Prevelence Of Impaired Fasting Glucose And Type 2 Diabetes, Afra Salah Alsammach
Theses
People with impaired fasting glucose (IFG) and type 2 diabetes (T2D) need to modify their dietary composition. This could assist in the management and prevention of the disease. However, the role played by the composition of specific dietary macronutrients on the risk of IFG & T2D needs further research. This study sought to examine the association between total and type of dietary protein (animal and plant) consumption with prevalence of T2D and IFG. Aims: To investigate the association between total intake and types (animal vs plant) of dietary protein intake and prevalence of IFG & T2D in adults. Data …
Newer Insights Into Mmtv Replication: The Human Retroviral Proteins Hiv-1 Tat And Htlv-1 Tax Can Transactivate The Mmtv Novel 5’ Element, Thanumol Abdul Khader
Newer Insights Into Mmtv Replication: The Human Retroviral Proteins Hiv-1 Tat And Htlv-1 Tax Can Transactivate The Mmtv Novel 5’ Element, Thanumol Abdul Khader
Dissertations
The mouse mammary tumor virus (MMTV) is a prototypic betaretrovirus that causes breast cancer in mice. MMTV regulates its gene expression both at the transcriptional and post transcriptional levels. It has hormonally-regulated promoters controlled by negative regulatory factors in a tissue-specific manner. Recently, we identified a novel 24-nucleotide region at the 5' end of the MMTV genome crucial for MMTV gene expression. Its deletion resulted in disruption of MMTV transcript elongation and stability, leading to a complete loss of Gag gene expression. This conserved element is present within the bifurcated stem loop 4, responsible for gRNA dimerization and encapsidation, into …
Utilization Of The Endophytic Fungus Piriformospora Indica To Improve Salinity Stress Tolerance: An Insight Into The Date Palm’S Transcriptomic And Functional Genomic Approaches, Miloofer Sabeem
Dissertations
Sustainable agriculture in arid and semi-arid regions depends on managing soil salinity, which is a major environmental issue and a critical component of sustainable food production. Salinity has a significant impact on date palm growth and physiological functions. Plant growth promoting microbiota has become a viable option to improve plant growth and performance under salt stress. Piriformospora indica is a highly versatile root endophyte in agricultural fields capable of coping with salinity. Its role in increasing abiotic stress tolerance has been reported in several plant species, but not in date palms. This research study investigated the growth, biochemical and molecular …
Anti Cancer Activity Of Rhus Coriaria (Sumac) Against 5-Fluorouracil-Resistant Colorectal Cancer Cells, Zohra Nausheen Nizami
Anti Cancer Activity Of Rhus Coriaria (Sumac) Against 5-Fluorouracil-Resistant Colorectal Cancer Cells, Zohra Nausheen Nizami
Theses
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths, both worldwide and in the UAE. 5-Fluorouracil (5-FU), a pyrimidine analogue, is a chemotherapeutic agent that is an integral component of chemotherapy regimens for CRC treatment. However, 5-FU resistance (intrinsic and/or acquired) inhibits their clinical efficacy. In recent years, there has been a growing popularity for plant-based cancer therapeutics, specifically using phytochemical compounds. Rhus coriaria (Sumac) is a Mediterranean plant whose fruits are used as a spice and medicinal herb. Extracts of Rhus coriaria fruits (RCE) have been reported to exhibit anti-cancer activity against breast cancer and CRC. In …
Modulation Of Chronic Allergic Contact Dermatitis Through B Cells, Sara Saeed Alhmoudi
Modulation Of Chronic Allergic Contact Dermatitis Through B Cells, Sara Saeed Alhmoudi
Theses
Allergic contact dermatitis (ACD) is a common inflammatory disease caused by contact with an allergen and is a T-cell-mediated type IV hypersensitivity reaction. Shortchain fatty acids (SCFAs) showed the ability to modulate immune cells in case of inflammation. Pentanoate is one of the abundant SCFA that showed therapeutic ability by inducing interleukin-10 (IL-10) secretion in lymphocytes. IL-10-producing regulatory B cells have been shown to decrease different inflammatory responses; however, the overall role of B cells in ACD is not well studied. This project aims to explore the role of B cells during chronic ACD and their modulation with the SCFA …
Modification Of Cellulose Fibers By Acyl Grafting For Oil Spill Remediation, Fatima Saif Alhumaidi
Modification Of Cellulose Fibers By Acyl Grafting For Oil Spill Remediation, Fatima Saif Alhumaidi
Theses
Oil spills represent a significant source of aquatic pollution with substantial repercussions on the environment as well as the economic and societal well-being of coastal communities. This research project is focused on the utilization of chemically modified cellulose-based fibers to remediate oil-contaminated water. The hydroxyl groups present in cellulose were acetylated under optimized conditions, thereby rendering the fibers hydrophobic and enhancing their affinity for crude oil. The modified cellulosic material was characterized by several physical and chemical techniques (IR, TGA, contact angle measurement, SEM, and back titration) to determine the extent of acylation and assess their morphological properties. The derivatized …
Voxelhap: A Toolkit For Constructing Proxies Providing Tactile And Kinesthetic Haptic Feedback In Virtual Reality, M. Feick, C. Biyikli, K. Gani, A. Wittig, Anthony Tang, A. Krüger
Voxelhap: A Toolkit For Constructing Proxies Providing Tactile And Kinesthetic Haptic Feedback In Virtual Reality, M. Feick, C. Biyikli, K. Gani, A. Wittig, Anthony Tang, A. Krüger
Research Collection School Of Computing and Information Systems
Experiencing virtual environments is often limited to abstract interactions with objects. Physical proxies allow users to feel virtual objects, but are often inaccessible. We present the VoxelHap toolkit which enables users to construct highly functional proxy objects using Voxels and Plates. Voxels are blocks with special functionalities that form the core of each physical proxy. Plates increase a proxy’s haptic resolution, such as its shape, texture or weight. Beyond providing physical capabilities to realize haptic sensations, VoxelHap utilizes VR illusion techniques to expand its haptic resolution. We evaluated the capabilities of the VoxelHap toolkit through the construction of a range …
“Is My Brain Ever Going To Work Fully Again?”: Challenges And Needs Of Cancer Survivors With Persistent Cancer-Related Cognitive Impairment, Darren Haywood, Evan Dauer, Frank D. Baughman, Blake J. Lawrence, Susan L. Rossell, Nicolas H. Hart, Moira O’Connor
“Is My Brain Ever Going To Work Fully Again?”: Challenges And Needs Of Cancer Survivors With Persistent Cancer-Related Cognitive Impairment, Darren Haywood, Evan Dauer, Frank D. Baughman, Blake J. Lawrence, Susan L. Rossell, Nicolas H. Hart, Moira O’Connor
Research outputs 2022 to 2026
Many cancer survivors experience cognitive impairments that impact memory, concentration, speed of information processing, and decision making. These impairments, collectively known as cancer-related cognitive impairments (CRCIs), are a key domain of unmet needs and can significantly impact a cancer survivor’s identity and quality of life. However, there are no purpose-built, multi-domain, needs assessment tools specifically for CRCI. The development of such tools requires an in-depth understanding of cancer survivors’ CRCI-specific challenges and associated needs. This study explored the challenges and associated needs of cancer survivors with persistent CRCI. An in-depth qualitative design using semi-structured interviews with (a) cancer survivors with …
Analysis Of Cycle 2 Science Textbooks For Representation Of Elements Contributing To Quality Science Textbooks As Learning Resources, Sohani Mehzabin Prova
Analysis Of Cycle 2 Science Textbooks For Representation Of Elements Contributing To Quality Science Textbooks As Learning Resources, Sohani Mehzabin Prova
Theses
Science textbooks are a valuable resource for both students and teachers. They hold a significant role in students' learning of science. Most science teachers in the United Arab Emirates (UAE) rely on science textbooks as the foundation for their teaching. However, until now, limited research has been conducted to assess the appropriateness of science textbooks prescribed by the Ministry of Education in the UAE. Therefore, this study aims to evaluate the representation of elements contributing to the suitability of cycle 2 (grades 5 to 8) science textbooks as learning resources as prescribed by the Ministry of Education of the UAE. …
Does A 15-Minute Brief Mindfulness Breathing Exercise Temporarily Enhance Inhibitory Control And Cognitive Flexibility? A Within-Subject Experimental Approach, Andree Hartanto, K. T. A. Sandeeshwara Kasturiratna, Yi Jing Chua, Judy Abigail Ngo, Shi Ying Jolene Ong, Frosch Yi Xuan Quek, Xun Ci Soh, Nadyanna M. Majeed
Does A 15-Minute Brief Mindfulness Breathing Exercise Temporarily Enhance Inhibitory Control And Cognitive Flexibility? A Within-Subject Experimental Approach, Andree Hartanto, K. T. A. Sandeeshwara Kasturiratna, Yi Jing Chua, Judy Abigail Ngo, Shi Ying Jolene Ong, Frosch Yi Xuan Quek, Xun Ci Soh, Nadyanna M. Majeed
Research Collection School of Social Sciences
Intensive mindfulness practices have been shown to improve cognitive abilities such as executive functions. However, most of these mindfulness-based practices require the participants to be involved either an extended immersive experience or repeated daily practice that may span over multiple weeks or months. Extending from the promising effect of intensive mindfulness training, recent studies have also suggested that a single session of brief mindfulness training is sufficient to temporarily enhance cognitive functions. However, the positive effect of brief mindfulness was not always consistent. In view of the inconsistent findings, the current study aims to critically examine the effectiveness of a …
November 2023 News Releases, University Of Montana--Missoula. Office Of University Relations
November 2023 News Releases, University Of Montana--Missoula. Office Of University Relations
University of Montana News Releases, 1928, 1956-present
No abstract provided.
Shifting The Male Gaze Of Evidence, Teneille R. Brown
Shifting The Male Gaze Of Evidence, Teneille R. Brown
Vanderbilt Law Review
Rationality is deeply embedded in both the Rules themselves and the ways they are interpreted. David Leonard stated that rationality "lies at the heart of modern evidentiary principles" because relevance itself is "grounded in rationality." Of the many reasons we have evidence rules-to streamline trials, foster legitimacy and predictability, and promote due process-encouraging "rational fact- finding" is often at the top of this list.
In contemporary evidence law the hegemonic goal-of-rationality is "often taken for granted" and can be traced "from Bentham through Wigmore to the present day." It is a "remarkably homogeneous" view that has "dominated legal scholarship for …
Selection Of Natural Surfactants For Possible Use In Improving Oil Recovery Of Carbonate Oil Reservoirs, Hiba Hachem Limam
Selection Of Natural Surfactants For Possible Use In Improving Oil Recovery Of Carbonate Oil Reservoirs, Hiba Hachem Limam
Theses
Middle East petroleum industry is currently searching for the most suitable enhanced oil technique to improve the oil recovery from local oil reservoirs. The biggest challenge for the application of enhanced oil recovery (EOR) in the Middle East is the harsh environment (high salinity and temperature). Surfactant (synthetic or natural) is one of the EOR major players considered for application in the Middle East. However, synthetic surfactants have several drawbacks, such as economically unattractive and environmental impacts. This study investigated the possible use of natural surfactant extracted from the leaves of three types of plants, namely Aloe Vera, Tetraena qatarensis, …
Ai Application In Architecture In Uae: Developing And Testing Advanced Optimization Model For A Parametric Shading Structure As A Retrofit Strategy Of A Midrise Residential Building Façade In Downtown Abu Dhabi, Anwar Ghaleb Ahmad
Theses
Artificial intelligence is a phenomenon that influences every aspect of our lives. AI applications have already started to change the methods in different disciplines. Architecture is one of the disciplines that is highly affected by the developments of AI technologies. With the United Arab Emirates heading to employ new technology to lead the country and region development, it is important to explore and develop the application of AI in the strategic disciplines of the country in which the built environment is essential. This study aimed to develop and evaluate an advanced model script (to be used as a tool) using …
An Examination Of The Association Between Sleep Quality And Psychological Distress Among University Students In The Middle East: A Cross-Sectional Correlational Study, Ayesha Saeed Alsuwaidi
An Examination Of The Association Between Sleep Quality And Psychological Distress Among University Students In The Middle East: A Cross-Sectional Correlational Study, Ayesha Saeed Alsuwaidi
Theses
Literature reviews have revealed that there are limited studies on sleep quality in the United Arab Emirates (UAE) and that few studies are available in the Middle Eastern region. The objective of this study was to examine the association between sleep quality and psychological distress among university students in the Middle East. A correlational cross-sectional design was determined, and a self-administered online questionnaire was used. The electronic survey was circulated amongst students on campus and received 435 responses from three universities namely, Menoufia University in Egypt, Sultan Qaboos University in the Sultanate of Oman, and United Arab Emirates University in …
Examining The Parallel Mediating Effect Of Emotion Dysregulation And Eating Beliefs In The Association Between Low Self¬-Esteem And Binge Eating Behaviours, Farah Al Mohammed
Examining The Parallel Mediating Effect Of Emotion Dysregulation And Eating Beliefs In The Association Between Low Self¬-Esteem And Binge Eating Behaviours, Farah Al Mohammed
Theses
Research in the United Arab Emirates (UAE) around the causes and non-pharmacological treatment options of binge eating behaviours and other eating disorders is limited. Moreover, given the documented increase in binge eating behaviours which, in turn, is associated with two additional eating disorders (i.e., binge eating disorder and bulimia nervosa), there is an urgent need to understand the factors that are implicated in the causation and maintenance of binge eating behaviours in the UAE. A comprehensive understanding of these factors will assist psychotherapists and other mental health professionals in tailoring the interventions that they provide in the treatment and management …
Canagliflozin Ameliorates Autistic-Like Features And Mitigates Brain Oxidative Stress Levels In Valproic Acid-Induced Autism In Rats, Mohammad Moutaz Nakhal
Canagliflozin Ameliorates Autistic-Like Features And Mitigates Brain Oxidative Stress Levels In Valproic Acid-Induced Autism In Rats, Mohammad Moutaz Nakhal
Theses
Autism spectrum disorder (ASD) is a neurodevelopmental disease with a substantially increasing incidence rate. It is mainly characterized by repetitive behavior, intellectual difficulties, social communication and interactions deficits. Many medications, dietary supplements, and behavioral treatments have been recommended for ASD management, however, there is no cure yet. Recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental diseases, based on their proved anti-inflammatory and antioxidant effects. The main objective of this study is to assess the ability of canagliflozin in improving the behavioural characteristics of autistic rats and investigate the efficacy of canagliflozin in …
Maladaptive Daydreaming And Social Anxiety: Prevalence And The Mediating Role Of Emotional Regulation, Riffa Fathima Abuthahir
Maladaptive Daydreaming And Social Anxiety: Prevalence And The Mediating Role Of Emotional Regulation, Riffa Fathima Abuthahir
Theses
Previous studies have generated mixed evidence regarding the magnitude of the prevalence of Maladaptive Daydreaming (MD). In addition, although previous studies have identified an association between Maladaptive Daydreaming (MD) and Social Anxiety (SA), literature is sparse in exploring the underlying factors such as emotional regulation difficulties that might mediate this relationship. The current study attempted to investigate the prevalence of MD and self-perceived levels of Social Anxiety (SA) among undergraduate students in the United Arab Emirates (UAE). It also attempted to explore whether difficulties in regulating emotions mediate the relationship between MD and self-perceived levels SA. A cross-sectional design with …
Association Of Human Leukocyte Antigen (Hla) Alleles With Atopic Dermatitis In The Uae Population, Suhib Ziad Abu Jwayed
Association Of Human Leukocyte Antigen (Hla) Alleles With Atopic Dermatitis In The Uae Population, Suhib Ziad Abu Jwayed
Theses
In the face of the increasing global prevalence of Atopic Dermatitis (AD), a chronic inflammatory skin condition, this thesis seeks to elucidate the genetic underpinnings of AD within the UAE population. Previous literature has underscored the ethnic-specific involvement of Human Leukocytes Antigen (HLA) genetic variations, especially within HLA-A and HLA-DRB1 genes, in the pathogenesis of various skin diseases, including AD. Leveraging this knowledge, our research specifically aimed to investigate the association between these HLA variants and AD in the UAE. Utilizing a comparative approach, the frequencies of HLA-A and HLA-DRB1 variants were assessed in AD patients vis-à-vis a control group. …
Biochemical Charactrization Of A Fructosyltransferase Enzyme From A Halophilic Archaeon, Haloarcula Marismotui, For Biotechnological Applications, Ahlam Khalifa Al Ameri
Biochemical Charactrization Of A Fructosyltransferase Enzyme From A Halophilic Archaeon, Haloarcula Marismotui, For Biotechnological Applications, Ahlam Khalifa Al Ameri
Theses
Fructosyltransferase enzymes are involved in the production of fructans, which are polymers of fructose and naturally present in many foods like fruits, vegetables, legumes, and cereals. Fructans with short chain lengths are called Fructooligosaccharides (FOS), which are small dietary fibers having low caloric values and are known as “prebiotics”. Fructans have a broad range of applications in the food, pharmaceutical, cosmetics, and chemical industries. They have unique physiochemical properties and functionalities depending on the source of enzyme used for their production. The present study aimed at the utilization of a recently discovered unique fructosyltransferase enzyme from an extremely halophilic microorganism, …
Use Of Root Endophytic Enterobacter Sp. Sa187 For The Improvement Of Abiotic Stress Tolerance Of Tomatoes Grown Under Greenhouse Conditions, Aysha Mohammad Rahmani
Use Of Root Endophytic Enterobacter Sp. Sa187 For The Improvement Of Abiotic Stress Tolerance Of Tomatoes Grown Under Greenhouse Conditions, Aysha Mohammad Rahmani
Theses
Agricultural productivity is largely affected by climate change. These climatic alterations translate into adverse abiotic stress conditions, such as heat, drought, and salinity, which restrict the geographical distribution of plants and limit their crop yields. Extreme conditions primarily affect semiarid and arid regions, causing severe environmental and economic repercussions. Plant growth-promoting rhizobacteria (PGPR) have been proposed to overcome these challenges. The desert plant endophytic bacterium Enterobacter sp. SA187 has shown beneficial effects on plant growth and salt stress tolerance in the model plant Arabidopsis thaliana in vitro, as well as under field conditions in different crops. This study aimed to …
Evaluation Of Rotenone Mediated Α-Synuclein Spreading And Neurotoxicity In Intra-Striatal Injection Of Α-Synuclein Pff Model Of Parkinson’S Disease, Engila Khan
Theses
In the last 25 years, the prevalence of Parkinson’s Disease (PD) across the globe has doubled. Clinical manifestations of this progressive neurodegenerative disorder include motor symptoms such as tremors, bradykinesia, postural instability, etc., which occur due to selective loss of dopaminergic neurons in the Substantia nigra (SNC) in the brain. The histopathological feature of PD is the presence of intra-neuronal aggregates of proteins called Lewy bodies, a major constituent of which is α-synuclein (α-syn).
Epidemiological studies to date have reported a connection between exposure to environmental neurotoxins such as Rotenone (a mitochondrial complex 1 inhibitor) and increased risk of PD …