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Articles 4111 - 4140 of 35238
Full-Text Articles in Entire DC Network
Real-Time Arrhythmia Detection Using Convolutional Neural Networks, Thong Vu, Tyler Petty, Kemal Yakut, Muhammad Usman, Wei Xue, Francis M. Haas, Robert A. Hirsh, Xinghui Zhao
Real-Time Arrhythmia Detection Using Convolutional Neural Networks, Thong Vu, Tyler Petty, Kemal Yakut, Muhammad Usman, Wei Xue, Francis M. Haas, Robert A. Hirsh, Xinghui Zhao
Henry M. Rowan College of Engineering Departmental Research
Cardiovascular diseases, such as heart attack and congestive heart failure, are the leading cause of death both in the United States and worldwide. The current medical practice for diagnosing cardiovascular diseases is not suitable for long-term, out-of-hospital use. A key to long-term monitoring is the ability to detect abnormal cardiac rhythms, i.e., arrhythmia, in real-time. Most existing studies only focus on the accuracy of arrhythmia classification, instead of runtime performance of the workflow. In this paper, we present our work on supporting real-time arrhythmic detection using convolutional neural networks, which take images of electrocardiogram (ECG) segments as input, and classify …
The Influence Of Grazing Systems On Bird Species Richness And Density In The Nebraska Sandhills, Silka L.F. Kempema, Walter H. Schacht, Larkin A. Powell
The Influence Of Grazing Systems On Bird Species Richness And Density In The Nebraska Sandhills, Silka L.F. Kempema, Walter H. Schacht, Larkin A. Powell
School of Natural Resources: Faculty Publications
Grazing is the de facto method of habitat management used in much of the Nebraska Sandhills. Ranchers use a variety of grazing systems, and our goal was to evaluate the effects of systems on grassland birds. We estimated the species richness and density of grassland birds for three grazing systems used on private ranches: long, medium, and short duration grazing systems. We observed sixty species, and the grazing system with pastures utilizing long duration grazing periods had the highest estimates of species richness as well as the most heterogeneous habitat structure. Differences in species richness among systems were most pronounced …
A Formative Evaluation Of ‘Mind Matters: Overcoming Adversity And Building Resiliency’ With Hispanic Adolescents Prior To And During Covid‑19, Heidi Adams Rueda, Abigail Vera, Arminda Marcial, Amanda Mariano
A Formative Evaluation Of ‘Mind Matters: Overcoming Adversity And Building Resiliency’ With Hispanic Adolescents Prior To And During Covid‑19, Heidi Adams Rueda, Abigail Vera, Arminda Marcial, Amanda Mariano
Social Work Faculty Publications
Youth living in poverty are more likely to experience cumulative stressors including multiple adverse childhood events. Further, the Covid-19 pandemic has disproportionality affected Hispanic youth and communities, leading to unprecedented levels of trauma. This research responded to a need for a youth resiliency-building program in an urban and impoverished area with a majority Hispanic population. We conducted a formative evaluation of a youth intervention entitled Mind Mat- ters: Overcoming Adversity and Building Resilience, which aims to help youth overcome adversity and to build resilience via psychoeducation and skill development. Just prior to the pandemic in the United States (August-December, …
"Operation Motivation" - Samuel Shepard Jr., Nicalee Stephens-Wilson
"Operation Motivation" - Samuel Shepard Jr., Nicalee Stephens-Wilson
Dissertations
African-American students have often faced systemic oppression and racial inequities as learners in the United States. Public schools in their communities lacked the resources to offer full access to a fair and equitable education. For years, human rights activists fought for radical changes in public schools. Finally, in 1954, the U. S. Supreme Court in Brown v. Board of Education ruled segregation in public schools unconstitutional. The Brown decision did not have the power to eliminate the long-established segregation practices. Nor did it grant access to educational equity for children of color. Dr. Samuel Shepard Jr. began his work in …
Promoting The Adoption Of Double Gloving Among Nurse Anesthetists: An Educational Intervention Based On The Theory Of Planned Behavior, Nguyet Tran
Doctoral Projects
Abstract
Background: The role of anesthetists in the transmission of pathogenic and non-pathogenic organisms from their work station to the patient has been well established in research. The proposed study aims to test the efficacy of an educational intervention in promoting double gloving in an effort to minimize the risk of cross-contamination.
Methods: This pilot study explored if multi-component educational intervention facilitates the adoption of double gloving and the prevention of cross-contamination in the anesthesia workstation. Student Registered Nurse Anesthetists (SRNAs) and Certified Registered Nurse Anesthetists (CRNAs) were followed in three evaluation phases; the first test was done before the …
Mechanisms And Opportunities For Rational In Silico Design Of Enzymes To Degrade Per- And Polyfluoroalkyl Substances (Pfas), Melissa Marciesky, Diana S. Aga, Ian M. Bradley, Nirupam Aich, Carla Ng
Mechanisms And Opportunities For Rational In Silico Design Of Enzymes To Degrade Per- And Polyfluoroalkyl Substances (Pfas), Melissa Marciesky, Diana S. Aga, Ian M. Bradley, Nirupam Aich, Carla Ng
Department of Civil and Environmental Engineering: Faculty Publications
Per and polyfluoroalkyl substances (PFAS) present a unique challenge to remediation techniques because their strong carbon−fluorine bonds make them difficult to degrade. This review explores the use of in silico enzymatic design as a potential PFAS degradation technique. The scope of the enzymes included is based on currently known PFAS degradation techniques, including chemical redox systems that have been studied for perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) defluorination, such as those that incorporate hydrated electrons, sulfate, peroxide, and metal catalysts. Bioremediation techniques are also discussed, namely the laccase and horseradish peroxidase systems. The redox potential of known reactants and …
Combating Invasive Species Through The Removal Of Pollution, Sarah J. Howell
Combating Invasive Species Through The Removal Of Pollution, Sarah J. Howell
High Impact Practices Student Showcase Fall 2023
The purpose of my project is to bring awareness to the issues of pollution on campus as well as encourage others to be more involved on campus through volunteerism. My time with the National Residence Hall Honorary (NRHH) and the Arboretum was very valuable. Not only was I able to learn how to identify/properly remove invasive species from an environment as well as how to generally help maintain the gardens at UCF but I was also able to learn about the value of community and working towards a common goal such as cleaning up Greek road. A Key activity that …
Clean The World: A Mission For Global Sanitation, Anisha B. Bissessar, Ahmad Shaqqou
Clean The World: A Mission For Global Sanitation, Anisha B. Bissessar, Ahmad Shaqqou
High Impact Practices Student Showcase Fall 2023
This presentation dives into our experience volunteering at Clean the World, an organization that recycles hygiene products to deliver to families across the world who don't have access to them. We learned more about what it means to be a servant leader through the welcoming and uplifting atmosphere the people working there created for us.
New Methods For Stereoselective Glycosylation In Application To Significant Biomedical Targets, Melanie L. Shadrick
New Methods For Stereoselective Glycosylation In Application To Significant Biomedical Targets, Melanie L. Shadrick
Dissertations
Glycosyl halides have been utilized for glycosylation reactions since the early studies by Arthur Michael, nearing the end of the 19th century. Koenigs and Knorr then utilized silver salts to activate glycosyl bromides and chlorides to create synthetic glycosides. Many efforts to improve the outcome of reactions with glycosyl halides have emerged. The key emphasis has traditionally been placed on reaction rates, product yields, and stereocontrol. Recently, our lab reported that silver(I) oxide-mediated Koenigs-Knorr glycosylation reaction can be dramatically accelerated in the presence of catalytic acid additives. Methods to improve glycosylation was explored using mannosyl and glucosyl bromides. However, …
Exploring Pathways To Food Science Careers In Southern California: A Case Study In Food Science Career Development, Jeremy L. Hsu, Sarah Ahles, Lilian W. Senger, Anuradha Prakash
Exploring Pathways To Food Science Careers In Southern California: A Case Study In Food Science Career Development, Jeremy L. Hsu, Sarah Ahles, Lilian W. Senger, Anuradha Prakash
Food Science Faculty Articles and Research
Southern California is a diverse region that is home to a high concentration of food science companies, with an increasing demand for additional food scientists and technologists to join this workforce. Despite this abundance of food science companies and the high demand for jobs, there is currently a shortage in the number of qualified food scientists and technologists in the region. This shortage is also observed within higher education, with declining enrollments in the food science graduate and undergraduate programs across Southern California. Here, we conduct a case study to explore the factors that influence students from Southern California to …
[Caranx Hippos (Jack Crevalle)] Neurocranium, Liat N. Castillo, Dylan J. Seiffert, David W. Kerstetter
[Caranx Hippos (Jack Crevalle)] Neurocranium, Liat N. Castillo, Dylan J. Seiffert, David W. Kerstetter
All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series
Neurocranium from [80cm TL] Caranx hippos (Jack Crevalle), collected from Merrit Island, Florida [9/18/2023] by Dylan Seiffert.
Evaluating The Efficacy Of Chatgpt In Navigating The Spanish Medical Residency Entrance Examination (Mir): Promising Horizons For Ai In Clinical Medicine., Francisco Guillen-Grima, Sara Guillen-Aguinaga, Laura Guillen-Aguinaga, Rosa Alas-Brun, Luc Onambele, Wilfrido Ortega, Rocio Montejo, Enrique Aguinaga-Ontoso, Paul Barach, Ines Aguinaga-Ontoso
Evaluating The Efficacy Of Chatgpt In Navigating The Spanish Medical Residency Entrance Examination (Mir): Promising Horizons For Ai In Clinical Medicine., Francisco Guillen-Grima, Sara Guillen-Aguinaga, Laura Guillen-Aguinaga, Rosa Alas-Brun, Luc Onambele, Wilfrido Ortega, Rocio Montejo, Enrique Aguinaga-Ontoso, Paul Barach, Ines Aguinaga-Ontoso
Department of Medicine Faculty Papers
UNLABELLED: The rapid progress in artificial intelligence, machine learning, and natural language processing has led to increasingly sophisticated large language models (LLMs) for use in healthcare. This study assesses the performance of two LLMs, the GPT-3.5 and GPT-4 models, in passing the MIR medical examination for access to medical specialist training in Spain. Our objectives included gauging the model's overall performance, analyzing discrepancies across different medical specialties, discerning between theoretical and practical questions, estimating error proportions, and assessing the hypothetical severity of errors committed by a physician.
MATERIAL AND METHODS: We studied the 2022 Spanish MIR examination results after excluding …
A Spatial Data Analysis Of Tennessee Accountability School Designations (Tasd) And Their Social, Economic, And Academic Make-Up, Taylor Ray Tartera
A Spatial Data Analysis Of Tennessee Accountability School Designations (Tasd) And Their Social, Economic, And Academic Make-Up, Taylor Ray Tartera
Electronic Theses and Dissertations Archive
This study looks closely at geography in education and the impact it has on the schools in Memphis, Tennessee. The location of a school can directly correlates with how successful the school will be- both with proficient test scores as well as funding and support from community stakeholders. Specific schools in Tennessee receive Tennessee Accountability School Designations (TASD). These designations are given to the highest and lowest-performing K-12 public schools in Tennessee. Memphis is Tennessee’s largest school district with a list of 36 schools who received a TASD for low-performing; while on the contrary, 44 schools earned a TASD for …
Lipid Membranes-Mediated Interactions And Self-Assembly Of Spherocylindrical Nanoparticles, Abash Sharma
Lipid Membranes-Mediated Interactions And Self-Assembly Of Spherocylindrical Nanoparticles, Abash Sharma
Electronic Theses and Dissertations Archive
This dissertation highlights the pivotal role of nanoparticles (NPs) anisotropy on their adhesion and potential self-assembly on lipid membranes. The research, which is performed in the context of spherocylindrical NPs (SCNPs), offers valuable insights into the complex interaction between NPs and lipid membranes and the utilization of lipid membranes as a medium for SCNPs self-assembly, potentially opening the door to various advanced applications. Modeling SNCPs as triangulated hollow shells, the adhesion modes and endocytosis of SCNPs on tensionless planar membranes are investigated using molecular dynamics simulations of a coarse-grained implicit-solvent model. The SCNPs are shown to adhere to the membrane …
Brain-Derived Neurotrophic Factor – A Key Player In The Gastrointestinal System, Arjun Singh
Brain-Derived Neurotrophic Factor – A Key Player In The Gastrointestinal System, Arjun Singh
Jefferson Hospital Staff Papers and Presentations
Brain-derived neurotrophic factor (BDNF) is highly expressed throughout the gastrointestinal (GI) tract and plays a critical role in the regulation of intestinal motility, secretion, sensation, immunity, and mucosal integrity. Dysregulation of BDNF signalling has been implicated in the pathophysiology of various GI disorders including inflammatory bowel disease, irritable bowel syndrome, functional dyspepsia, and diabetic gastroenteropathy. This review provides a comprehensive overview of BDNF localization, synthesis, receptors, and signalling mechanisms in the gut. In addition, current evidence on the diverse physiologic and pathophysiologic roles of BDNF in the control of intestinal peristalsis, mucosal transport processes, visceral sensation, neuroimmune interactions, gastrointestinal mucosal …
Suzanne "Suzy" Wood, Oral History Interview, 2023, Finn Vincent-Fix, Matt Jones
Suzanne "Suzy" Wood, Oral History Interview, 2023, Finn Vincent-Fix, Matt Jones
Oral Histories
Suzanne “Suzy” Wood attended the Roosevelt School K-12, she graduated a year before the school’s closure in 1969. In this interview, Suzy recounts growing up in the Normal Park neighborhood and activities kids did while living there in the 1950s-60s, and her experiences attending Roosevelt as a studious honors student who stayed out of trouble. Suzy also discusses meeting her husband, Nelson, while at Roosevelt, what dates looked like in the 1960s, and her life beyond Roosevelt.
Tulathromycin Metaphylaxis Increases Nasopharyngeal Isolation Of Multidrug Resistant Mannheimia Haemolytica In Stocker Heifers, William B. Crosby, Brandi B. Karisch, Lari M. Hiott, Lee J. Pinnell, Alexandra Pittman, Jonathan G. Frye, Charlene R. Jackson, John Dustin Loy, William B. Epperson, John Blanton Jr., Sarah F. Capik, Paul S. Morley, Amelia R. Woolums
Tulathromycin Metaphylaxis Increases Nasopharyngeal Isolation Of Multidrug Resistant Mannheimia Haemolytica In Stocker Heifers, William B. Crosby, Brandi B. Karisch, Lari M. Hiott, Lee J. Pinnell, Alexandra Pittman, Jonathan G. Frye, Charlene R. Jackson, John Dustin Loy, William B. Epperson, John Blanton Jr., Sarah F. Capik, Paul S. Morley, Amelia R. Woolums
School of Veterinary and Biomedical Sciences: Faculty Publications
Bovine respiratory disease (BRD) is a leading cause of disease in feedlot and stocker calves with Mannheimia haemolytica (MH) as one of the most common etiologies. One of the most effective means of controlling BRD is through metaphylaxis, which involves administering antimicrobials to all animals at high risk of developing BRD. However, increasing prevalence of multidrug resistant (MDR) MH may reduce efficacy of metaphylaxis due to decreased susceptibility to drugs used for metaphylaxis. Primarily, this study aimed to determine the effect of tulathromycin metaphylaxis and subsequent BRD treatment on antimicrobial resistance (AMR) in MH isolated from stocker calves. Secondary objectives …
Ud Biology Student Studies Frog Teeth Evolution In Faculty-Mentored Research Project, Lucy Waskiewicz
Ud Biology Student Studies Frog Teeth Evolution In Faculty-Mentored Research Project, Lucy Waskiewicz
College of Arts and Sciences Newsroom
Madeline Brinkman studied developmental evidence for the re-evolution of frog teeth through the Dean's Summer Fellowship program.
“...I Have My Dad, Sister, Brother, And Mom’S Password”: Unveiling Users’ Mental Models Of Security And Privacy-Preserving Tools, Prakriti Dumaru, Ankit Shrestha, Rizu Paudel, Cassity Haverkamp, Maryellen Mcclain Verdoes, Mahdi Nasrullah Al-Ameen
“...I Have My Dad, Sister, Brother, And Mom’S Password”: Unveiling Users’ Mental Models Of Security And Privacy-Preserving Tools, Prakriti Dumaru, Ankit Shrestha, Rizu Paudel, Cassity Haverkamp, Maryellen Mcclain Verdoes, Mahdi Nasrullah Al-Ameen
Computer Science Student Research
Purpose: Security and privacy-preserving tools (for brevity, we term them as ‘security tools’ in this paper, unless otherwise specified) are designed to protect the security and privacy of people in the digital environment. However, inappropriate use of these tools can lead to unexpected consequences that are preventable. Hence, it is significant to examine why users do not understand the security tools.
Methodology: We conducted a qualitative study with 40 participants in the USA to investigate the prevalent misconceptions of people regarding security tools, their perceptions of data access, and the corresponding impact on their usage behavior and data protection strategies. …
The Contributions Of Mental Health Issues, Traumatic Brain Injury, And Adverse Childhood Experiences To Recidivism Among Rural Jail Incarcerees, Lauren N. Miley
The Contributions Of Mental Health Issues, Traumatic Brain Injury, And Adverse Childhood Experiences To Recidivism Among Rural Jail Incarcerees, Lauren N. Miley
USF Tampa Graduate Theses and Dissertations
Recidivism should be a major concern, particularly for American jails. The Unites States incarcerates 2.3 million people, a number exceeding rates in any other country. Approximately 90% of those individuals will reenter society at some point, and roughly half of those people will ultimately return to jail. This revolving door costs U.S. taxpayers upwards of $39 billion per year, and undermines public safety. Therefore, breaking this cycle of incarceration and recidivism is of utmost concern, and the focus of this dissertation. Mental health problems, traumatic brain injury (TBI), and adverse childhood experiences (ACEs) are three potential risk factors for recidivism …
Enhanced Luminescence Efficiency In Eu-Doped Gan Superlattice Structures Revealed By Terahertz Emission Spectroscopy, Fumikazu Murakami, Atsushi Takeo, Brandon Mitchell, Volkmar Dierolf, Yasufumi Fujiwara, Masayoshi Tonouchi
Enhanced Luminescence Efficiency In Eu-Doped Gan Superlattice Structures Revealed By Terahertz Emission Spectroscopy, Fumikazu Murakami, Atsushi Takeo, Brandon Mitchell, Volkmar Dierolf, Yasufumi Fujiwara, Masayoshi Tonouchi
Physics & Engineering Faculty Publications
Eu-doped Gallium nitride (GaN) is a promising candidate for GaN-based red light-emitting diodes, which are needed for future micro-display technologies. Introducing a superlattice structure comprised of alternating undoped and Eu-doped GaN layers has been observed to lead to an order-of-magnitude increase in output power; however, the underlying mechanism remains unknown. Here, we explore the optical and electrical properties of these superlattice structures utilizing terahertz emission spectroscopy. We find that ~0.1% Eu doping reduces the bandgap of GaN by ~40 meV and increases the index of refraction by ~20%, which would result in potential barriers and carrier confinement within a superlattice …
Empowering Futures: Matthew's Knights Of Distinction Leadership E-Portfolio In Academic Excellence, Matthew A. Hernandez
Empowering Futures: Matthew's Knights Of Distinction Leadership E-Portfolio In Academic Excellence, Matthew A. Hernandez
High Impact Practices Student Showcase Fall 2023
My presentation centers on my E-Portfolio, seamlessly incorporating three key milestones from the Knights of Distinction program into significant events. Beginning with a brief personal introduction, I shared why I became a physics major, and explored the roots of my passion for space. Utilizing a visual aid, my poster board, I elucidated each focus area and its relevance to my aspirations and societal contributions. The first focus area was Citizenship and how I attended an “Industry BBQ” with the hopes of gaining valuable information to share it with other engineers. The second focus area was about leadership and my role …
Low-Dose Prednisone Or Methylprednisolone In Treating Patients With Newly Diagnosed Acute Gvhd, Dillon C. Hill, Melanie Obsina, Juan Sanchez, Jordan Genco, Vihan Yalamanchili
Low-Dose Prednisone Or Methylprednisolone In Treating Patients With Newly Diagnosed Acute Gvhd, Dillon C. Hill, Melanie Obsina, Juan Sanchez, Jordan Genco, Vihan Yalamanchili
High Impact Practices Student Showcase Fall 2023
Graft Versus Host Disease affects less than 20,000 cases per year and our project aims to give those who experience this terrible disease a better outcome and more manageable pain. The clinical trial that this data is collected from analyzes low-dose prednisone versus the standard dose and how that affects both morbidity and progression of the disease to Stage III-IV. This clinical trial has many clinical implications as it shows that reducing the dosage of commonly used treatment methods can sometimes have positive effects even though it is the standard to use a certain dose. This clinical trial found that …
Neutrosophic Sets And Systems, Vol. 60, 2023, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi
Neutrosophic Sets And Systems, Vol. 60, 2023, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi
Neutrosophic Sets and Systems
No abstract provided.
School Counselors’ Perspectives On Drama-Free Tweens Program For Black Tween Girls’ Behavior, Linda Thomas Poindexter
School Counselors’ Perspectives On Drama-Free Tweens Program For Black Tween Girls’ Behavior, Linda Thomas Poindexter
Walden Dissertations and Doctoral Studies
No abstract provided.
A Network Pharmacology And Molecular-Docking-Based Approach To Identify The Probable Targets Of Short-Chain Fatty-Acid-Producing Microbial Metabolites Against Kidney Cancer And Inflammation, Md Rezaul Karim, Md Niaj Morshed, Safia Iqbal, Shahnawaz Mohammad, Ramya Mathiyalagan, Deok Chun Yang, Yeon Ju Kim, Joon Hyun Song, Dong Uk Yang
A Network Pharmacology And Molecular-Docking-Based Approach To Identify The Probable Targets Of Short-Chain Fatty-Acid-Producing Microbial Metabolites Against Kidney Cancer And Inflammation, Md Rezaul Karim, Md Niaj Morshed, Safia Iqbal, Shahnawaz Mohammad, Ramya Mathiyalagan, Deok Chun Yang, Yeon Ju Kim, Joon Hyun Song, Dong Uk Yang
Faculty, Staff and Student Publications
(1) Background: A large and diverse microbial population exists in the human intestinal tract, which supports gut homeostasis and the health of the host. Short-chain fatty acid (SCFA)-secreting microbes also generate several metabolites with favorable regulatory effects on various malignancies and immunological inflammations. The involvement of intestinal SCFAs in kidney diseases, such as various kidney malignancies and inflammations, has emerged as a fascinating area of study in recent years. However, the mechanisms of SCFAs and other metabolites produced by SCFA-producing bacteria against kidney cancer and inflammation have not yet been investigated. (2) Methods: We considered 177 different SCFA-producing microbial species …
Examples Of Neutrohyperstructures On Biological Inheritance, Fakhry Asad Agusfrianto, Madeleine Al-Tahan, Mariam Hariri, Yudi Mahatma
Examples Of Neutrohyperstructures On Biological Inheritance, Fakhry Asad Agusfrianto, Madeleine Al-Tahan, Mariam Hariri, Yudi Mahatma
Neutrosophic Sets and Systems
No abstract provided.
Finalists Announced: 2023 Social Venture Innovation Challenge, Sustainability Institute
Finalists Announced: 2023 Social Venture Innovation Challenge, Sustainability Institute
Sustainability Institute Blog
No abstract provided.
Mechanisms, Evolution, And Rapid Diagnosis Of Carbapenem Resistance, Taalin Shale Hoj
Mechanisms, Evolution, And Rapid Diagnosis Of Carbapenem Resistance, Taalin Shale Hoj
Theses and Dissertations
An estimated 70% of bacterial infections in the United States are resistant to first-line antibiotics. Of these, among the most difficult to treat are highly resistant to carbapenems, an antibiotic class used as a last resort. Septicemia, particularly when caused by a carbapenem-resistant organism, is among the most challenging clinical scenarios to treat, with an overall mortality rate of carbapenem-resistant septicemias 63.8%. Encouragingly, if effective antimicrobial treatment begins within 1-3 hours of septic shock onset, patient survival rates are around 80%. The first section of this work describes a real-time PCR-based assay that when coupled with existing bacteria-blood separation technology, …
Elucidating The Architecture Of The Tclijn Complex That Converts Cysteine To Thiazoles In The Biosynthesis Of Micrococcin, Diana G. Calvopina Chavez
Elucidating The Architecture Of The Tclijn Complex That Converts Cysteine To Thiazoles In The Biosynthesis Of Micrococcin, Diana G. Calvopina Chavez
Theses and Dissertations
Thiopeptides are a family of antimicrobial peptides that are characterized for having sulfur-containing heterocycles, and for being highly post-translationally modified. Numerous thiopeptides have been identified; almost all of which inhibit protein synthesis in gram-positive bacteria. These intrinsic antimicrobial properties make thiopeptides promising candidates for the development of new antibiotics. The antimicrobial peptide micrococcin is a thiopeptide that is synthesized by the ribosome and undergoes several post-translational modifications (PTMs). Micrococcin is formed from a precursor peptide, TclE. TclE comprises an N-terminal leader (35-AA) that is crucial for recognition of the PTM machinery, alongside a C-terminal core sequence (14-AA) that undergoes multiple …