Digital Commons Network^™

The Victimization Experiences Of Transgender Adult Females Of Color In The State Of Florida, Andrew Ryan Vaz

Walden Dissertations and Doctoral Studies

No abstract provided.

How Carvedilol Does Not Activate Β2-Adrenoceptors, Robert J. Lefkowitz, Howard A. Rockman, Paul J. Shim, Samuel Liu, Seungkirl Ahn, Biswaranjan Pani, Sudarshan Rajagopal, Sudha K. Shenoy, Michel Bouvier, Jeffrey L. Benovic, Stephen B. Liggett, Robert R. Ruffolo, Michael R. Bristow, Milton Packer

Department of Biochemistry and Molecular Biology Faculty Papers

No abstract provided.

Delineating The Interplay Between Oncogenic Pathways And Immunity In Anaplastic Wilms Tumors, Xiaoping Su, Xiaofan Lu, Sehrish Khan Bazai, Linda Dainese, Arnauld Verschuur, Benoit Dumont, Roger Mouawad, Li Xu, Wenxuan Cheng, Fangrong Yan, Sabine Irtan, Véronique Lindner, Catherine Paillard, Yves Le Bouc, Aurore Coulomb, Gabriel G Malouf

Faculty, Staff and Student Publications

Wilms tumors are highly curable in up to 90% of cases with a combination of surgery and radio-chemotherapy, but treatment-resistant types such as diffuse anaplastic Wilms tumors pose significant therapeutic challenges. Our multi-omics profiling unveils a distinct desert-like diffuse anaplastic Wilms tumor subtype marked by immune/stromal cell depletion, TP53 alterations, and cGAS-STING pathway downregulation, accounting for one-third of all diffuse anaplastic cases. This subtype, also characterized by reduced CD8 and CD3 infiltration and active oncogenic pathways involving histone deacetylase and DNA repair, correlates with poor clinical outcomes. These oncogenic pathways are found to be conserved in anaplastic Wilms tumor cell …

The Non-Coding Rnome After Splenectomy, Yoshiki Kobayashi, Hanh Hong Chu, Dan Van Bui, Yasutaka Yun, Linh Manh Nguyen, Akitoshi Mitani, Kensuke Suzuki, Mikiya Asako, Akira Kanda, Hiroshi Iwai

Faculty, Staff and Student Publications

Eosinophilic airway inflammation, complicated by bronchial asthma and eosinophilic chronic rhinosinusitis (ECRS), is difficult to treat. The disease may become refractory when eosinophilic mucin associated with eosinophil peroxidase (EPX) and autoantibodies fills in the paranasal sinus and small airway. This study investigated the functional role of an anti-EPX antibody in eosinophilic mucin of ECRS in eosinophilic airway inflammation. Eosinophilic mucin was obtained from patients with ECRS. The effects of the anti-EPX antibody on dsDNA release from eosinophils and eosinophilic mucin decomposition were evaluated. Immunofluorescence or enzyme-linked immunosorbent assays were performed to detect the anti-EPX antibody and its supernatant and serum …

Attempts To Understand Oral Mucositis In Head And Neck Cancer Patients Through Omics Studies: A Narrative Review, Erin Marie D San Valentin, Kim-Anh Do, Sai-Ching J Yeung, Cielito C Reyes-Gibby

Faculty, Staff and Student Publications

Oral mucositis (OM) is a common and clinically impactful side effect of cytotoxic cancer treatment, particularly in patients with head and neck squamous cell carcinoma (HNSCC) who undergo radiotherapy with or without concomitant chemotherapy. The etiology and pathogenic mechanisms of OM are complex, multifaceted and elicit both direct and indirect damage to the mucosa. In this narrative review, we describe studies that use various omics methodologies (genomics, transcriptomics, microbiomics and metabolomics) in attempts to elucidate the biological pathways associated with the development or severity of OM. Integrating different omics into multi-omics approaches carries the potential to discover links among host …

Cannabinoids In Periodontology: Where Are We Now?, Yésica Carmona Rendón, Hernán Santiago Garzón, Bruno Bueno-Silva, Roger M Arce, Lina Janeth Suárez

Faculty, Staff and Student Publications

Introduction: Cannabinoids are a well-documented treatment modality for various immune and inflammatory diseases, including asthma, chronic obstructive pulmonary disease, Crohn's disease, arthritis, multiple sclerosis, and a range of neurodegenerative conditions. However, limited information is available regarding the therapeutic potential of cannabinoids in treating periodontal disease.

Objective: The objective of this study is to analyze the current evidence on the antibacterial and immunomodulatory effects of cannabis and its role in the healing and regeneration processes within periodontal tissues.

Results: This review discusses the potential role of cannabinoids in restoring periodontal tissue homeostasis.

Conclusions: The examination of the endocannabinoid system and the …

Racial Disparities Among Predicted Bronchopulmonary Dysplasia Risk Outcomes In Premature Infants Born <30 Weeks Gestation, Priyanka Patel, Andrew Ellefson, David A. Paul

Department of Pediatrics Faculty Papers

Background and Objective: There is extensive literature to support eliminating race-based risk stratification. The National Institute of Child Health and Human Development (NICHD) calculator, used to predict risk of bronchopulmonary dysplasia (BPD), includes race as a variable. We sought to investigate how utilizing race in determination of risk for BPD may lead to inequitable care.

Methods: The study included a retrospective cohort of infants born <30 weeks gestation between January 2016 and February 2022. The primary outcome was the difference in predictive risk of BPD for non-Hispanic Black compared to non-Hispanic White infants. The secondary outcome was the disparity in theoretical administration of post-natal corticosteroids when the calculator was applied to the cohort. Analysis included paired T-tests and Chi-Square.

Results: Of the 273 infants studied, 154 were non-Hispanic Black (56%). There was no difference between the groups in gestation or respiratory support on day of life (DOL) 14 or 28. …

The Lived Experiences Of Esl Nontraditional Rrts While Preparing To Challenge The National Board For Respiratory Care Clinical Simulation Exam, Jose A. Lammoglia

Theses and Dissertations

This applied dissertation was designed to provide information to respiratory therapy graduates from two-year associate in science programs, faculty, and administrators about

the cognitive and noncognitive strategies employed by graduates to prepare and pass the CSE. To date, no available information on the role played by the lived experiences of RT graduates while preparing to challenge the CSE. The researcher developed a questionnaire to conduct a qualitative phenomenological descriptive lived experience survey of ESL Hispanic nontraditional graduates from associate of science programs in South Florida who took the NBRC national board examinations between January 2015 and March 2022.

An analysis …

Skin Barrier Function: The Interplay Of Physical, Chemical, And Immunologic Properties, Paola Baker, Christina Huang, Rakan Radi, Samara B Moll, Emmanuela Jules, Jack L Arbiser

Student Papers, Posters & Projects

An intact barrier function of the skin is important in maintaining skin health. The regulation of the skin barrier depends on a multitude of molecular and immunological signaling pathways. By examining the regulation of a healthy skin barrier, including maintenance of the acid mantle and appropriate levels of ceramides, dermatologists can better formulate solutions to address issues that are related to a disrupted skin barrier. Conversely, by understanding specific skin barrier disruptions that are associated with specific conditions, such as atopic dermatitis or psoriasis, the development of new compounds could target signaling pathways to provide more effective relief for patients. …

Stmut: A Framework For Visualizing Somatic Alterations In Spatial Transcriptomics Data Of Cancer, Limin Chen, Darwin Chang, Bishal Tandukar, Delahny Deivendran, Joanna Pozniak, Noel Cruz-Pacheco, Raymond J Cho, Jeffrey Cheng, Iwei Yeh, Chris Marine, Boris C Bastian, Andrew L Ji, A Hunter Shain

Staff and Researcher Publications

Spatial transcriptomic technologies, such as the Visium platform, measure gene expression in different regions of tissues. Here, we describe new software, STmut, to visualize somatic point mutations, allelic imbalance, and copy number alterations in Visium data. STmut is tested on fresh-frozen Visium data, formalin-fixed paraffin-embedded (FFPE) Visium data, and tumors with and without matching DNA sequencing data. Copy number is inferred on all conditions, but the chemistry of the FFPE platform does not permit analyses of single nucleotide variants. Taken together, we propose solutions to add the genetic dimension to spatial transcriptomic data and describe the limitations of different datatypes.

World War Two Propaganda: Analyzing And Comparing German And American Strategies, Chandler Schubert '24

Senior Scholarly and Creative Symposium

No abstract provided.

Trees In Our City How A Tree And A Small Patch Of Dirt Inspired A Classroom, Zuleika Hines

Occasional Paper Series

As a new Director in a new school, I knew that I wanted the children to have a curiosity for nature. But to lead the children to a place of discovery, they would need the opportunity to observe, play, and engage in elements of nature that would support hands-on activities both in the classroom and outside. When the opportunity came for me to build my own early childhood program, I knew that I had a unique opportunity to incorporate elements of nature in the design of the classroom. But I wanted nature to be local and the trees of our …

Singing In Dark Times: Improvisational Singing With Children Amidst Ecological Crisis, Stephanie Schuurman-Olson

Occasional Paper Series

Through this research-creation project -- which is represented by a process-driven ten-minute video -- the author asks what ways of knowing emerge when children and adults, more-than-human, and inhuman engage in improvised singing together in an urban park? This project recognizes our current "dark times" within ecological collapse and operates from a space that hopes to build relationality with sonic ecologies through listening-and-singing experiences, while centering the voices of children and other singers within the ecologies we sing in-and-with.

Connecting Children And Young People With Trees, Gill Forrester, Jo Maker, Will Price, Hollie Davison, Heather Gilbert

Occasional Paper Series

Engaging children and young people with the natural world has never been more important. The benefits of outdoor learning span from increased nature connection to improved self-esteem and physical wellbeing. But with so many potential risks and barriers, how can we help practitioners feel confident and capable in an outdoor setting and therefore improve access to green space for children and young people? The education team at the National Forest Company set out to tackle this challenge. The National Forest was established in the early 1990s in a post-industrial area of the English Midlands. It covers 200 square miles and …

Thermo-Kinetic Parameters Governing Decomposition Of Amino Acids: A Computational Study, Mubarak Taleb Alkwradi

Thesis/ Dissertation Defenses

Amino acid model compounds are important nitrogenated species that in various categories of biomass. These compounds exhibit unique fragmentation pathways because of their adjacent amino and hydroxyl groups. Comprehending the decomposition chemistry of amino acids is essential to reduce harmful nitrogen emissions during biomass thermal treatment. This research reports the kinetic and thermodynamic properties of amino acids, and sulfur-containing amino acid, based on accurate density functional theory calculations coupled with kinetic modelling. The first part of the thesis provides comprehensive thermochemical parameters for the complete set of amino acids in the gas phase. The optimized geometries of amino acid compounds …

Towards Strengthening Methods In Design Education And Practice, Jorge Frascara, Paul Gardien, Guillermina Noël, Daniel Rosenberg, Pieter Jan Stappers, Danielle Wilde

Learn X Design Conference Series

No abstract provided.

Neurodesign: A Game-Changer In Educational Contexts, Mario Ivan Zignego, Alessandro Bertirotti, Paolo Andrea Gemelli, Laura Pagani

Learn X Design Conference Series

No abstract provided.

The Flipped Design Classroom: Effectiveness Of Online Lectures, Katja Fleischmann

Learn X Design Conference Series

No abstract provided.

Digital Teaching For Classes In Studios, Practice Rooms, And Labs, Dagmar Steffen

Learn X Design Conference Series

No abstract provided.

Advanced Design Thinking (Adt): A Pathway To Deschooling Design, Ricardo Sosa, Andrew Gibbons, Amabel Hunting

Learn X Design Conference Series

No abstract provided.

From Consumer Capitalism To Wellbeing: Re-Imagining Futures Of Design Education In The View Of Pluriverse, Karina Vissonova, Michael Hohl

Learn X Design Conference Series

No abstract provided.

A Critical Inquiry On Design Cognition And Generative Systems, Aysel Merve Topaloglu

Learn X Design Conference Series

No abstract provided.

Teaching Practices On More-Than-Human Perspectives In Hci Education – Current State And Future Paths, Eva Eriksson, Elisabet M. Nilsson, Tilde Bekker, Daisy Yoo

Learn X Design Conference Series

In times of climate emergency and artificial intelligence affecting everything in life, we must reconsider the way we teach our students how to become responsible designers of future technologies. In recent years we have seen a rise in interest in more-than-human perspectives in human-computer interaction (HCI), where more-than-human things, species, and designers move the field beyond traditional human-centred approaches. In this paper, we set out to explore how this new approach is taught, what we can learn from it, and what challenges remain. The contribution of this paper is an overview of a selection of more-than-human teaching practices and curriculum …

Blood, Sweat And Tears: A Design Education Research Publication Story, Naz Börekçi

Learn X Design Conference Series

No abstract provided.

Teaching Design Ethics Through Tabletop Game Prototyping, Dimitrios Gkouskos, Andrea Resmini, Charlotte Shahlaei, Jonathan Burgos

Learn X Design Conference Series

No abstract provided.

The Decision, Victor Udoewa

Learn X Design Conference Series

No abstract provided.

Unfixing The Studio, James Corazzo, Derek Jones, Frazer Hudson

Learn X Design Conference Series

No abstract provided.

Design From Waste Materials: Situation, Problem, And Solution, Luke Feast, Linda Nhu Laursen

Learn X Design Conference Series

No abstract provided.

Review Of "The North Star: Canada And The Civil War Plots Against Lincoln" By Julian Sher, Tim Cook

Canadian Military History

Review of The North Star: Canada and the Civil War Plots against Lincoln by Julian Sher

Controlled Radiation Capsule For Precision And Rapid Cancer Treatment, Hoseon Lee, Zsolt Kollar, Bailey R. White, Junia Nguyen, David Roque, Sowjanya Palagani

Symposium of Student Scholars

This research aims to transform cancer treatment through the optimization of brachytherapy, with a focus on reducing treatment duration, setup complexities, and financial burdens, all while emphasizing patient safety. Patients living at a distance from radiation clinics, particularly those undergoing extended Low Dose Radiation brachytherapy, often struggle with the formidable financial challenges associated with securing nearby accommodations. In response to these issues, the research introduces a radiation capsule designed to condense the conventional six-month treatment period to approximately just one week, thereby significantly reducing the duration of required accommodations. This capsule is especially relevant considering the construction cost of $40 …