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2023

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Inventory Management In Supply Chains With Consideration Of Transportation And Green Technology Cost Under Progressive Carbon Taxation, Ming-Feng Yang, Min-Der Ko, Hung-Jen Tu, Mengru Tu, Jun-Yuan Kuo, Yen-Ting Chao, Shang-Wei Shih Jan 2023

Inventory Management In Supply Chains With Consideration Of Transportation And Green Technology Cost Under Progressive Carbon Taxation, Ming-Feng Yang, Min-Der Ko, Hung-Jen Tu, Mengru Tu, Jun-Yuan Kuo, Yen-Ting Chao, Shang-Wei Shih

Journal of Marine Science and Technology–Taiwan

Reducing carbon emissions is an important issue in the global supply chain. Governments have formulated different carbon policies to achieve carbon neutrality or emission reduction, in particular, the carbon tax as a policy provides greater certainty about the potential cost to emitters. The Taiwan government is expected to implement the carbon tax policy in 2024 and does not rule out the inclusion of a progressive mechanism which is more effective than a single carbon tax in curbing high carbon emissions Recent studies have also confirmed that a high level and complete carbon tax could encourage companies to invest in green …

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Geohash-Based Arrangement Of Live-Fire Exercise Areas Using Ais, Sang-Lok Yoo, Cho-Young Jung Jan 2023

Geohash-Based Arrangement Of Live-Fire Exercise Areas Using Ais, Sang-Lok Yoo, Cho-Young Jung

Journal of Marine Science and Technology–Taiwan

Live-fire exercise (LFX) areas at sea threaten the safety of ships, whereas, and indiscriminately abandoned unexploded bombs threaten the lives of fishermen. No statistical or scientific research has been conducted on the appropriate locations for LFX areas. Therefore, this study proposes a method for effectively arranging the LFX areas at sea that considers the safety of passing ships and national security. First, the proposed method classifies ship tracking data collected in the daytime based on the dawn and dusk times of the civil twilight phase. Second, the method uses a Geohash geocoding process to identify whether an LFX area coincides …

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Assessing Hierarchical Corporate Sustainability Transition Practices Under Uncertainty: An Approach In The Port And Shipping Industry In Southeast Asia, Mei-Train Yeh, Feng-Ming Tsai, Taufik Kurrahman Jan 2023

Assessing Hierarchical Corporate Sustainability Transition Practices Under Uncertainty: An Approach In The Port And Shipping Industry In Southeast Asia, Mei-Train Yeh, Feng-Ming Tsai, Taufik Kurrahman

Journal of Marine Science and Technology–Taiwan

The port and shipping industry in Southeast Asia has experienced significant development in response to the increasing demand for maritime logistics and transportation services. However, this expansion has resulted in notable social and environmental impacts. Consequently, it is imperative for both scholars and practitioners to comprehend the concept of corporate sustainability transition (CST), which entails the establishment of shipping operations that effectively balance environmental, social, and economic considerations. Additionally, technologies that are used to facilitate the transition process must be investigated. Several studies have been undertaken to ascertain the attributes pertaining to sustainability transition. Nevertheless, there has been a lack …

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Research On Risk Assessment Of Container Operation Process In Ports Considering Functional Areas, Chen-Yu Lin, Ming-Jiu Hwang, Tzu-Heng Yen Jan 2023

Research On Risk Assessment Of Container Operation Process In Ports Considering Functional Areas, Chen-Yu Lin, Ming-Jiu Hwang, Tzu-Heng Yen

Journal of Marine Science and Technology–Taiwan

The risk management of container ports has drawn significant attention recently in part because of recent high-profile accidents in global container ports and in part due to the increasing focus on port safety as a key element in sustainable maritime transportation. This research presented a novel, two-layer container port risk assessment model by partitioning the container port into four areas based on the process of container transportation: loading and unloading, in-port container transportation, storage, and gate areas. Failure mode and effects analysis (FMEA) and quantitative risk analysis modeling were combined for each part of the process to evaluate the risk …

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Artificial Intelligence In Prediction Of The Remaining Useful Life Of Wind Turbine Shaft Bearings, Jinsiang Shaw, B.J. Wu Jan 2023

Artificial Intelligence In Prediction Of The Remaining Useful Life Of Wind Turbine Shaft Bearings, Jinsiang Shaw, B.J. Wu

Journal of Marine Science and Technology–Taiwan

Long-term periodic rotation and unstable load changes in wind turbines can cause unexpected damage to high-speed shaft bearings (HSSBs). In this study, after preprocessing of the HSSB vibration signal, four different models for predicting bearing degradation in terms of remaining useful life (RUL) in days were investigated: support vector regression (SVR), convolutional neural networks (CNN), long short-term memory (LSTM), and CNN-LSTM. The experimental results revealed that the CNN achieved the best mean absolute error (MAE), at 0.44 days, based on frequency response plot using the fast Fourier transform (FFT), while that of the CNN-LSTM model predicted using the amplitude profile …

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Impact Of Multiple Water Temperature Structures On The Behavioral Pattern Of Chum Salmon (Oncorhynchus Keta) On The Coast Of The Shiretoko Peninsula, Xinyi Li, Hiroshi Yamaguchi, Hokuto Shirakawa, Kenji Minami, Nobuhiko Sato, Yanhui Zhu, Yasuyuki Miyakoshi, Kazushi Miyashita Jan 2023

Impact Of Multiple Water Temperature Structures On The Behavioral Pattern Of Chum Salmon (Oncorhynchus Keta) On The Coast Of The Shiretoko Peninsula, Xinyi Li, Hiroshi Yamaguchi, Hokuto Shirakawa, Kenji Minami, Nobuhiko Sato, Yanhui Zhu, Yasuyuki Miyakoshi, Kazushi Miyashita

Journal of Marine Science and Technology–Taiwan

During the migration of chum salmon (Oncorhynchus keta) towards the Shiretoko Peninsula in Hokkaido, Japan, the convergence of coastal currents results in the formation of intricate water temperature structures. However, the impact of this phenomenon on the behavioral tendencies of chum salmon remains largely unexplored. In 2012 and 2013, we conducted a study to document the vertical water temperature profiles and uninterrupted swimming patterns of homing chum salmon in the coastal waters surrounding the Shiretoko Peninsula. The results indicated that chum salmon exhibited a preference for avoiding thermoclines characterized by rapidly decreasing water temperatures. They were predominantly observed swimming either …

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Research On The Collision Risk Of Ships Off Keelung Based On Ais Data, Shih-Tzung Chen, Ming-Feng Yang, Sheng-Long Kao, Mengru Tu, Jun-Yuan Kuo, Yen-Ting Chao, Huang-Kai Hsu Jan 2023

Research On The Collision Risk Of Ships Off Keelung Based On Ais Data, Shih-Tzung Chen, Ming-Feng Yang, Sheng-Long Kao, Mengru Tu, Jun-Yuan Kuo, Yen-Ting Chao, Huang-Kai Hsu

Journal of Marine Science and Technology–Taiwan

In previous literature, several computational methods have been proposed to analyze collision risks for vessels navigating at sea, most of which rely on the calculation of DCPA and TCPA between two vessels. However, this study adopts an enhanced version of the Vessel Conflict Ranking Operator (VCRO) to assess vessel collision risks. This approach not only considers the relative distance and relative velocity between two vessels but also takes their relative aspect into account. This methodology was applied to real-world vessels’ dynamic data collected through AIS. From a near-collision perspective, it identifies high-risk areas near Keelung water where commercial vessels and …

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Cooling Performance Analysis For Mobile Vehicles By Thermal Resistance Network, Chia-An Yang, Jung-Chang Wang, Pi-Hsia Yen Jan 2023

Cooling Performance Analysis For Mobile Vehicles By Thermal Resistance Network, Chia-An Yang, Jung-Chang Wang, Pi-Hsia Yen

Journal of Marine Science and Technology–Taiwan

This paper used CFD software to simulate the cooling situation of the engine space of a mobile vehicle. We used thermal resistance network diagram to calculate the heat flux at each position of the power system, and discussed the CFD simulation results. The error between the simulation results and the experiment was 10.07%. The thermal resistance network diagram proposed in this paper can reduce the time for numerical simulation by evaluate the heat flux at each position of the power system.

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Microbial Community And Genome Structure In Coastal Seawater From A Commercial Port And Nearby Offshore Island In Northern Taiwan, Chi-Yu Shih, Ching-Hsiang Chin, Shiow-Yi Chen, Chun-Ru Hsu, Lee-Kuo Kan, Wen-Shyong Tzou Jan 2023

Microbial Community And Genome Structure In Coastal Seawater From A Commercial Port And Nearby Offshore Island In Northern Taiwan, Chi-Yu Shih, Ching-Hsiang Chin, Shiow-Yi Chen, Chun-Ru Hsu, Lee-Kuo Kan, Wen-Shyong Tzou

Journal of Marine Science and Technology–Taiwan

The pollution stemming from the use of petroleum by boats, the presence of deceased marine life, hazardous chemicals, and wastewater is a major issue in human-made commercial ports. This pollution poses a considerable challenge to the diverse organisms inhabiting the seawater. To comprehend the impact of this pollution on the microbiome, we conducted a study in which we collected surface water samples from a commercial port called Keelung Port, as well as a nearby offshore island known as Keelung Islet. These locations are situated in northern Taiwan, along the Northwestern Pacific Ocean. Through the use of whole-metagenome shotgun sequencing, we …

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Effects Of Perpetrator And Victim Gender, Rape Myths, And Report Timing On Blame Attributions Following Sexual Assault, Katherine E. Kennon Jan 2023

Effects Of Perpetrator And Victim Gender, Rape Myths, And Report Timing On Blame Attributions Following Sexual Assault, Katherine E. Kennon

College of Graduate Studies: Theses & Dissertations

Previous research examined the effects of victim gender, perpetrator gender, and rape myth acceptance on victim blaming attribution; however, fewer studies explore victim and perpetrator gender at the same time, and even fewer studies examined the relevance of factors like timing of reporting (immediate or delayed) or rurality. The primary purpose of the study, therefore, was to explore the effect of victim gender, perpetrator gender, and report timing (same day vs. six months later) on victim blaming attributions. The study also examined the role of rape myth acceptance on victim blame and compared levels of rape myth acceptance across participant …

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Training Specificity And Functional Performance In Collegiate Cheerleaders, Carly Routman Jan 2023

Training Specificity And Functional Performance In Collegiate Cheerleaders, Carly Routman

College of Graduate Studies: Theses & Dissertations

INTRODUCTION: Competitive collegiate cheerleading requires participants to be conditioned for explosive powerful movements. Studies have shown cheerleading is associated with a high incidence of catastrophic injury (Mueller, 2009; Boden, 2005; Xu et al., 2021). In response to high injury rates, studies have recommended strength and conditioning requirements to decrease the likelihood of injury due to the lack of cheer-specific training (Jacobson et al., 2004). Although it has been recommended for cheerleaders to receive formal strength training, many schools do not provide these resources to their cheerleading teams. PURPOSE: The purpose of this study was to determine if there are differences …

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Evaluation Of The Loving Support Peer Counseling Program On Breastfeeding Duration Rates Among African American Women Enrolled In The Program (2017-2018), Nancy S. Jeffery Jan 2023

Evaluation Of The Loving Support Peer Counseling Program On Breastfeeding Duration Rates Among African American Women Enrolled In The Program (2017-2018), Nancy S. Jeffery

College of Graduate Studies: Theses & Dissertations

Mothers and babies form an inseparable biological and social unit; the health and nutrition of one group cannot be divorced from the health and nutrition of the other.”-World Health Organization. The aim of this study was to evaluate the effectiveness of the Loving Support Peer Counseling (LSPC) program, under the WIC program in the state of Georgia, on breastfeeding duration rates among African American postpartum primiparas women. This observational study analyzed state-level data from January 2017 through December 2018. A cross-sectional design was used to evaluate the effectiveness of the Loving Support Peer Counseling Program (LSPC) in six of the …

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Common Data Set, 2022-2023, Planning, Research, And Policy Analysis Jan 2023

Common Data Set, 2022-2023, Planning, Research, And Policy Analysis

Common Data Set (2001-present)

Common Data Set 2022-2023 for Illinois State University

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The Effect Of Metalation On Antimicrobial Piscidins Imbedded In Normal And Oxidized Lipid Bilayers, Ana Dreab, Craig A. Bayse Jan 2023

The Effect Of Metalation On Antimicrobial Piscidins Imbedded In Normal And Oxidized Lipid Bilayers, Ana Dreab, Craig A. Bayse

Chemistry & Biochemistry Faculty Publications

Metalation of the N-terminal Amino Terminal Cu(II)- and Ni(II)-binding (ATCUN) motif may enhance the antimicrobial properties of piscidins. Molecular dynamics simulations of free and nickelated piscidins 1 and 3 (P1 and P3) were performed in 3 : 1 POPC/POPG and 2.6 : 1 : 0.4 POPC/POPG/aldo-PC bilayers (POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine: POPG, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol; aldo-PC, 1-palmitoyl-2-(9′-oxo-nonanoyl)-sn-glycero-3-phosphocholine) bilayer models. Nickel(II) binding decreases the conformation dynamics of the ATCUN motif and lowers the charge of the N-terminus to allow it to embed deeper in the bilayer without significantly changing the overall depth due to interactions of the charged half-helix …

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Phosphate And Borophosphate Glasses For Optical And Biomedical Applications, Parker Tracy Freudenberger Jan 2023

Phosphate And Borophosphate Glasses For Optical And Biomedical Applications, Parker Tracy Freudenberger

Doctoral Dissertations

"The goal of this work was to connect the network structures of phosphate and borophosphate glasses to the compositional dependence of properties related to biomedical applications. The glasses were characterized by a variety of techniques, including phosphate ion chromatography, Raman spectroscopy, and 11B and 31P Magic Angle Spinning Nuclear Magnetic Resonance spectroscopy, which provide qualitative and quantitative information about the phosphate and borate moieties that constitute the network structures. The systematic addition of borate to a phosphate glass initially creates tetrahedral borate sites that replace P-O-P linkages with B-O-P linkages, and the properties of the resulting borophosphate glasses …

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Advances In Differentially Methylated Region Detection And Cure Survival Models, Daniel Ahmed Alhassan Jan 2023

Advances In Differentially Methylated Region Detection And Cure Survival Models, Daniel Ahmed Alhassan

Doctoral Dissertations

"This dissertation focuses on two areas of statistics: DNA methylation and survival analysis. The first part of the dissertation pertains to the detection of differentially methylated regions in the human genome. The varying distribution of gaps between succeeding genomic locations, which are represented on the microarray used to quantify methylation, makes it challenging to identify regions that have differential methylation. This emphasizes the need to properly account for the correlation in methylation shared by nearby locations within a specific genomic distance. In this work, a normalized kernel-weighted statistic is proposed to obtain an optimal amount of "information" from neighboring locations …

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Essays On Conditional Heteroscedastic Time Series Models With Asymmetry, Long Memory, And Structural Changes, K C M R Anjana Bandara Yatawara Jan 2023

Essays On Conditional Heteroscedastic Time Series Models With Asymmetry, Long Memory, And Structural Changes, K C M R Anjana Bandara Yatawara

Doctoral Dissertations

"The volatility of asset returns is usually time-varying, necessitating the introduction of models with a conditional heteroskedastic variance structure. In this dissertation, several existing formulations, motivated by the Generalized Autoregressive Conditional Heteroskedastic (GARCH) type models, are further generalized to accommodate more dynamic features of asset returns such as asymmetry, long memory, and structural breaks. First, we introduce a hybrid structure that combines short-memory asymmetric Glosten, Jagannathan, and Runkle (GJR) formulation and the long-memory fractionally integrated GARCH (FIGARCH) process for modeling financial volatility. This formulation not only can model volatility clusters and capture asymmetry but also considers the characteristic of long …

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The Effect Of Face Interpretation Training On Social Anxiety Symptoms, Grace L. Wheeler Jan 2023

The Effect Of Face Interpretation Training On Social Anxiety Symptoms, Grace L. Wheeler

Graduate Theses, Dissertations, and Problem Reports (ETD)

According to cognitive models of social anxiety disorder (SAD), individuals place excessive importance on gauging others’ reactions (e.g., facial expressions) to their social performance. Facial interpretation bias modification (FIBM) was developed to shift interpretations of ambiguous faces. The current study uses FIBM to test whether face interpretation is causally related to SAD symptoms in an unselected adult sample. Participants (N=139) were randomized to 1 of 3 conditions (positive, negative, accurate) in a single-session, online study. Pre- and post- intervention measures of face interpretation and SAD were completed. In line with hypotheses, individuals in the positive condition interpreted faces more positively …

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Deadly Divisions: Class And Stigma As Fundamental Social Causes Of Spatial Health Inequalities, Misty Lee Harris Jan 2023

Deadly Divisions: Class And Stigma As Fundamental Social Causes Of Spatial Health Inequalities, Misty Lee Harris

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this dissertation is to investigate how class and stigma influence spatial inequalities in health across the US, from the structural to the individual level. Class, stigma, and subsequent access to capital resources are not equally distributed across the US. Women, poor, and minority populations continue to have unequal access to capital resources across the country, though this is spatially determined. Similarly, while there are health inequalities along the same social cleavages at the national level, they differ significantly across localities. Research has not paid enough attention to the fundamental social causes of inequities, resulting in the inability …

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Longitudinal Oxygen Imaging In 3d (Bio)Printed Models, Ryan Curtis O'Connell Jan 2023

Longitudinal Oxygen Imaging In 3d (Bio)Printed Models, Ryan Curtis O'Connell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Electron paramagnetic resonance (EPR), and its molecular imaging modality, is a powerful tool to noninvasively map various biological and chemical markers within objects of interest. Reliable data acquisition is a major impeding factor for longitudinal hands-off measurements. Measurements are especially challenging in biomedical applications, as live objects are not static. Frequent changes occur that require constant fine recalibration of the EPR detection system, called the resonator. To enable longitudinal imaging, a technology permitting automatic digital control of resonator coupling, tuning, and EPR data acquisition was developed. Automation was achieved through the utilization of a microcontroller and digital peripheral components such …

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Blowdown Wastewater Co-Treatment With Produced Water For Resource Recovery: Moving Towards Zero Liquid Discharge And Sustainable Waste Management, Mohammad Hafez Ahmed Jan 2023

Blowdown Wastewater Co-Treatment With Produced Water For Resource Recovery: Moving Towards Zero Liquid Discharge And Sustainable Waste Management, Mohammad Hafez Ahmed

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cooling of low-pressure steam and flue gas desulfurization (FGD) process at coal-fired powerplants often require large quantities of freshwater and can generate waste streams from the blowdown (BD) operations. Treating these wastewaters for reuse can offset the freshwater demand, which is beneficial especially in semiarid and arid regions. However, the traditional treatment (i.e., chemical softening and evaporation) of cooling BD water (BDW) is chemical- and energy-intensive and adds to the overall costs of water management for powerplants. Furthermore, the updated Effluent Limitation Guidelines and Standards for powerplants set forth by the U.S. Environmental Protection Agency (EPA) …

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The Portrayal Of Disability In 19th And 20th Century American Novels, Taylor Whittington Jan 2023

The Portrayal Of Disability In 19th And 20th Century American Novels, Taylor Whittington

College of Graduate Studies: Theses & Dissertations

This thesis explores the treatment of disabled characters by their family and communities in 19th and 20th - century American literature. The three works being evaluated are, The Monster (1898) by Stephen Crane, The Sound and The Fury (1928) by William Faulkner, and Of Mice and Men (1937) by John Steinbeck. Although The Sound and The Fury and Of Mice and Men contain a white disabled character, The Monster details the disfiguration of an African American man. In The Monster, race exacerbates the community’s response to the disfigured Henry Johnson, compared to Lennie in Of Mice and Men, …

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Mofx-Db: An Online Database Of Computational Adsorption Data For Nanoporous Materials, N. Scott Bobbitt, Kaihang Shi, Benjamin J. Bucior, Haoyuan Chen, Nathaniel Tracy-Amoroso, Zhao Li Jan 2023

Mofx-Db: An Online Database Of Computational Adsorption Data For Nanoporous Materials, N. Scott Bobbitt, Kaihang Shi, Benjamin J. Bucior, Haoyuan Chen, Nathaniel Tracy-Amoroso, Zhao Li

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Machine learning and data mining coupled with molecular modeling have become powerful tools for materials discovery. Metal–organic frameworks (MOFs) are a rich area for this due to their modular construction and numerous applications. Here, we make data from several previous large-scale studies in MOFs and zeolites from our groups (and new data for N2 and Ar adsorption in MOFs) easily accessible in one place. The database includes over three million simulated adsorption data points for H2, CH4, CO2, Xe, Kr, Ar, and N2 in over 160 000 MOFs and 286 zeolites, textural properties like pore sizes and surface areas, and …

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Intersectionality Of Self-Reported Food Insecurity And Perceived Stress Of College Students At A Land-Grant Southeastern Higher Education Institution During The Covid-19 Pandemic, Kendra Oonorasak, Makenzie Barr, Michael Pennell, Dylan Hardesty, Kotomi Yokokura, Samantha Udarbe, Tammy Stephenson Jan 2023

Intersectionality Of Self-Reported Food Insecurity And Perceived Stress Of College Students At A Land-Grant Southeastern Higher Education Institution During The Covid-19 Pandemic, Kendra Oonorasak, Makenzie Barr, Michael Pennell, Dylan Hardesty, Kotomi Yokokura, Samantha Udarbe, Tammy Stephenson

Journal of Higher Education & Student Affairs

College food insecurity (FI) and poor psychosocial health are prevalent public health issues in the U.S., yet often overlooked. Since the COVID-19 pandemic, repercussions on these critical inequity issues remain unclear. During the summer months of 2020, this cross-sectional survey examined associations between students’ self-reported FI and perceived stress (PSS-10), one aspect of poor psychosocial health. An anonymous online survey was distributed to a convenience sample of college students at a land grant institution of higher education in the southeastern U.S., and $10 e-gift card was provided to survey respondents. The survey response rate was 26.2% (n=235) and participants were …

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Are Epicuticular Waxes A Surface Defense Comparable To Trichomes? A Test Using Two Solanum Species And A Specialist Herbivore., Sakshi Watts, Rupesh R. Kariyat Jan 2023

Are Epicuticular Waxes A Surface Defense Comparable To Trichomes? A Test Using Two Solanum Species And A Specialist Herbivore., Sakshi Watts, Rupesh R. Kariyat

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Although plants possess a suite of structural defenses, most studies have focused on trichomes. Trichomes can have both pre- and post-ingestive effects and have been consistently found to reduce herbivory. Along with trichomes, a few studies have focused on epicuticular waxes as an important defense; however, manipulated comparisons examining herbivore growth and development is limited. In this study, using two Solanum species (Solanum glaucescens and Solanum macrocarpon) that vary in both defenses, we tested the hypothesis that variation in defenses will affect herbivore feeding, primarily by restricting feeding commencement. We used electron microscopy together with a series of plant- and …

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Docking, Synthesis Of Some Novel Flavonoid Analogues, And Their Biological Evaluation, Ishwar Bhat K, Afiya Abdul Aziz, Abhishek Kumar, Vijaya Bhaskar K, Vijay Kumar M Jan 2023

Docking, Synthesis Of Some Novel Flavonoid Analogues, And Their Biological Evaluation, Ishwar Bhat K, Afiya Abdul Aziz, Abhishek Kumar, Vijaya Bhaskar K, Vijay Kumar M

The Thai Journal of Pharmaceutical Sciences

Cancer remains a major class of morbidity and mortality despite basic and clinical research and trials of promising new therapies. In the current era, many drugs are marketed with flavonoid nucleus. Based on this information, this study aims to synthesize and screen flavones for their anticancer activity. Docking studies for cytotoxic activity of flavonoid derivatives targeting tankyrase enzyme were performed. A new series of flavonoid derivatives were prepared from chalcones. Chalcones were prepared between substituted benzaldehyde and 2-hydroxy acetophenone in the presence of potassium hydroxide as catalyst. The flavone derivatives were characterized based on IR, 1H NMR, and Mass spectral …

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Effects Of Quercetin And Its Derivatives On Mirnas And Inflammatory Mediators In Inflammation: A Systematic Review, Benediktus Wastu Paramabodhi, Eva Annisaa, Widyandani Sasikirana, Wimzy Rizqy Prabhata Jan 2023

Effects Of Quercetin And Its Derivatives On Mirnas And Inflammatory Mediators In Inflammation: A Systematic Review, Benediktus Wastu Paramabodhi, Eva Annisaa, Widyandani Sasikirana, Wimzy Rizqy Prabhata

The Thai Journal of Pharmaceutical Sciences

Quercetin has been known to have anti-inflammatory effects. Information regarding the anti-inflammatory effects of quercetin or its derivatives on inflammatory mediators and miRNAs is abundant and varied. However, a comprehensive understanding of its pharmacological actions at the cellular and molecular levels needs to be studied. Therefore, quercetin and its derivatives were studied in this systematic review to investigate how they affect the expressions of miRNAs and inflammatory mediators and their respective roles in the mechanisms of anti-inflammatory actions. A literature search in PubMed and Scopus databases was carried out based on the PRISMA protocol. Out of 2964 articles identified, 47 …

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Anti-Diabetic Activity Of Bauhinia Strychnifolia Craib Stem Extract In Alloxan-Induced Diabetic Rats, Peerarat Thaina, Nattapaul Rattanamusik, Teepakorn Saraphee, Suriyan Tengyai, Attarat Pattanawongsa, Panupong Puttarak Jan 2023

Anti-Diabetic Activity Of Bauhinia Strychnifolia Craib Stem Extract In Alloxan-Induced Diabetic Rats, Peerarat Thaina, Nattapaul Rattanamusik, Teepakorn Saraphee, Suriyan Tengyai, Attarat Pattanawongsa, Panupong Puttarak

The Thai Journal of Pharmaceutical Sciences

The α-glucosidase inhibitory and antioxidant activities of Bauhinia strychnifolia Craib in vitro have been explored; however, its effectiveness in vivo is still unknown. This study examined the hypoglycemic effects of B. strychnifolia extract. Acute toxicity was also investigated in mice using the up-and-down method. The experiments were carried out in both sexes of Wistar rats and female ICR mice. The results showed that the oral LD50 of the plant extract was greater than 5000 mg/kg. For the anti-diabetic investigation, diabetes was induced in rats by subcutaneous injection of alloxan (125 mg/kg). The hypoglycemic effect was evaluated by oral administration of …

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In-Vivo Antidiabetic Activity And In-Silico Mode Of Action Of Gc-Ms Identified Phytoconstituents In Rhynshosia Cana, Praveena Yempada, Arya Lakshmi Marrisetti, Ganga Rao Battu Jan 2023

In-Vivo Antidiabetic Activity And In-Silico Mode Of Action Of Gc-Ms Identified Phytoconstituents In Rhynshosia Cana, Praveena Yempada, Arya Lakshmi Marrisetti, Ganga Rao Battu

The Thai Journal of Pharmaceutical Sciences

Plants have been a primary medicinal source for thousands of years and are utilized time immemorial as popular traditional folk medicine. Rhynchosia cana (R. cana) had therapeutic qualities. In this research, the entire plant R. cana was exposed to maceration with methanol. This plant's methanol extract (MERC) was tested using Gas Chromatography-Mass Spectrometry (GC-MS), which shows 11 main components. Compounds discovered in-silico mechanism of action showed inhibition of α-Amylase and α-glucosidase enzymes. In vitro technique, the MERC also showed α-Amylase and α-glucosidase inhibition. Streptozocin-induced diabetes model evaluated the antihyperglycemic activity in vivo. Single intraperitoneal Streptozotocin injection at a dosage of …

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Cardiomyocyte-Specific Modified Mrna For Myocardial Regeneration In A Porcine Myocardial Infarction Model, Jiacheng Sun Jan 2023

Cardiomyocyte-Specific Modified Mrna For Myocardial Regeneration In A Porcine Myocardial Infarction Model, Jiacheng Sun

All ETDs from UAB

The inability of adult mammalian cardiomyocytes (CMs) to undergo cell renewal following ischemic injury stands as a major impediment to heart function recovery and contributes to heart failure (HF). Current therapeutic approaches do not offer an effective approach of reactivating CM cell division to prevent HF in humans. Recognizing this challenge, gene therapy has emerged as a promising approach to promote CM proliferation and enhance cardiac repair. A particularly notable approach is the utilization of modified mRNA (modRNA), which provides a safe, controlled, transient, non-viral, and clinically relevant means of gene delivery. The study was conducted using a novel cardiomyocyte …

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