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Exploring Ph Gradient Phenomena In Non-Linear Electrokinetic Microfluidic Devices, Azade Tahmasebi

Dissertations, Master's Theses and Master's Reports

Electrokinetic microfluidics is a versatile technology utilized within lab on a chip (LOC) devices for diagnostic and analytical applications; advantages include reduced resource demands, flexibility, and simplicity of use. Dielectrophoresis (DEP) is a precision nonlinear electrokinetic tool utilized within microfluidic microdevices to induce polarization and control bioparticle motions for applications that range from hemoglobin separations to cancer cell isolation and detection. Despite promising results, undesired side phenomena can occur in electrokinetic systems which impede reproducibility and accuracy. These unfavorable phenomena have not been comprehensively explored in the literature. Prior preliminary research suggests the fundamental phenomena originate from microelectrodes utilized in …

Under Ice Photosynthetic Primary Production And Dark Carbon Fixation In A Temperate Freshwater System, Vanessa Cubillos Tellez

Dissertations, Master's Theses and Master's Reports

Ice-covered lakes are vulnerable to environmental change, especially those in the Northern Hemisphere where ice cover is rapidly declining due to global warming. These changes can alter metabolic processes and disrupt carbon cycling driven by primary producers who form the base of the food chain and are key to sustaining ecosystem function. Photosynthetic primary production and dark carbon fixation under the ice in the Keweenaw Waterway, a temperate freshwater system that is ice-covered for ~3 months out of the year, were studied using a carbon isotopic labeling (14C-bicarbonate) technique. Water samples were collected weekly during ice cover and monthly during …

Study Of Electronic And Magnetic Properties Of Bilayer Graphene Nanoflakes And Bimetallic Chalcogenides Using First-Principles Density Functional Theory And Machine Learning, Dharmendra Pant

Dissertations, Master's Theses and Master's Reports

Graphene, a one-atom-thick material, has been a wonder material since its discovery because of its superlative electronic, mechanical, and optical properties. When a layer of graphene is rotated over another layer, it exhibits many intriguing behaviors, ranging from superconductivity to the anomalous Hall effect to ferromagnetism at a magic angle of 1°, and hence the twisted bilayer graphene has been the subject of intense research in recent years. The surge in interest in this moiré structure can be attributed to the emergence of electronic flat minibands near the magic angle. Here, we studied the electronic and magnetic properties of twisted …

Neuromorphic Computing Applications In Robotics, Noah Zins

Dissertations, Master's Theses and Master's Reports

Deep learning achieves remarkable success through training using massively labeled datasets. However, the high demands on the datasets impede the feasibility of deep learning in edge computing scenarios and suffer from the data scarcity issue. Rather than relying on labeled data, animals learn by interacting with their surroundings and memorizing the relationships between events and objects. This learning paradigm is referred to as associative learning. The successful implementation of associative learning imitates self-learning schemes analogous to animals which resolve the challenges of deep learning. Current state-of-the-art implementations of associative memory are limited to simulations with small-scale and offline paradigms. Thus, …

Dissecting The Role Of Selenoprotein P And Thioredoxin Reductase In Pancreatic Cancer Metabolism, Alyssa A. Abbas

Dissertations, Master's Theses and Master's Reports

Pancreatic ductal adenocarcinoma (PDAC), the fourth leading cause of US cancer-related deaths, has a stark 5-year survival rate of 9%, emphasizing an urgent need for effective therapies. A well-established characteristic of cancer, metabolic dysregulation, presents an opportunity for developing therapies that target specific metabolic susceptibilities inherent in cancer cells. Our recent studies have discovered a susceptibility in PDAC; deprivation of cystine or blocking its uptake by erastin (a cystine transport inhibitor) triggers significant lipid peroxidation, thereby inducing ferroptosis specifically in the mesenchymal subtype of PDAC, but not in the epithelial subtype. This study aims to elucidate the roles of Selenoprotein …

Awareness And Prevention Of Syphilis Infections In Women In Pima County, Arizona, Sharon M. Watson

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement: The goal of this social change portfolio is to reduce the rate of syphilis infections in women by increasing the availability of comprehensive sexual health education, improving the accessibility of affordable and free healthcare and STI/D testing, and developing community intervention programs that address the additional risk factors that contribute to the rise in syphilis rates.

Significant Findings: Arizona has had a 449% increase in syphilis rates in women since 2015, with Pima County ranking as the county with the second-highest increase in rates (AZDHS, 2023). These startling increases in rates are clearly evident across the nation. The …

On Chip Microfluidic Separation Of Cyclotides, Reza Didarian, Aliakbar Ebrahimi, Hamed Ghorbanpoor, Hesam Bagheroghli, Fatma Doğan Güzel, Mohsen Farhadpour, Nasrin Lotfibakhshayesh, Hossein Hashempour, Hüseyi̇n Avci

Turkish Journal of Chemistry

Cyclotides as a cyclic peptide produced by different groups of plants have been a very attractive field of research due to their exceptional properties in biological activities and drug design applications. The importance of cyclotides as new biological activities from nature caused to attract researchers to develop new separation systems. Recent growth and development on chip-based technology for separation and bioassay especially for anticancer having sparklingly advantages comparison with common traditional methods. In this study, the microfluidic separation of Vigno 1-5 cyclotides extracted from Viola ignobilis by using polar and nonpolar forces as a liquid-liquid interaction was investigated through modified …

Alexander Von Humboldt: Explorer, Naturalist, And Environmental Pioneer (2019) By Danica Novgorodoff, Peter Shea

Picture Books

As a young boy, Alexander Von Humboldt came up with divergent questions about the birds and mountains and animals he saw, and brought all those questions together under two big questions that stayed important for him over a long life: “How are these things different?” and “How are they nevertheless connected?” As the reader watches Humboldt looking at a hawk and a mouse, volcanoes and farmland, palm trees and pine trees, Europe and Ecuador, Europeans and Indigenous people, one comes to expect what he will say: “They are different, and yet they are connected.” This idea is much bigger than …

“A Plague Broke Out Among Them”: Reflections On The Bible And The Pandemic, Joel Kaminsky

Religion: Faculty Publications

This essay seeks to utilize ideas and texts found in the Hebrew Bible in order to historically contextualize the COVID-19 pandemic and to illuminate various existential, religious, political, and ethical issues raised by the current pandemic and our responses to it.

Integration Host Factor Binds Dna Holliday Junctions, Shawn H. Lin, Dacheng Zhao, Vivian Deng, Veronica K. Birdsall, Suzanne Ho, Olga Buzovetsky, Candice M. Etson, Ishita Mukerji

Physics: Faculty Publications

Integration host factor (IHF) is a nucleoid-associated protein involved in DNA packaging, integration of viral DNA and recombination. IHF binds with nanomolar affinity to duplex DNA containing a 13 bp consensus sequence, inducing a bend of ~160° upon binding. We determined that IHF binds to DNA Four-way or Holliday junctions (HJ) with high affinity regardless of the presence of the consensus sequence, signifying a structure-based mechanism of recognition. Junctions, important intermediates in DNA repair and homologous recombination, are dynamic and can adopt either an open or stacked conformation, where the open conformation facilitates branch migration and strand exchange. Using ensemble …

Editorial: Professional And Scientific Societies Impacting Diversity, Equity And Inclusion In Stemm, Verónica A. Segarra, Candice M. Etson

Physics: Faculty Publications

No abstract provided.

Hydrophobicity Of The Biofunctionalized Scaffolds For Bone Tissue Engineering Application In Dentistry, Ridhayani Hatta, Beatriz Jc. Monteiro, Ilida O. Asencio

Journal of Dentomaxillofacial Science

No abstract provided.

The Relationship Between The Expression Of Stromal Cell Derived Factor-1 (Sdf-1) And Regional Acceleratory Phenomenon (Rap) In Orthodontic Tooth Movement After Tooth Extraction In Rats Model, Duangtawan Rintanalert

Chulalongkorn University Theses and Dissertations (Chula ETD)

The stromal cell-derived factor 1 (SDF-1)/chemokine receptor type 4 (CXCR4) axis plays a key role in alveolar bone metabolism during orthodontic tooth movement (OTM). Herein, the effects of the SDF-1/CXCR4 axis on the regional acceleratory phenomenon (RAP) in OTM velocity and on changes in the surrounding periodontium after adjacent tooth extraction in rats were investigated. Six-week-old male Wistar/ST rats underwent left maxillary first molar (M1) extraction and mesial OTM of the left maxillary second molar (M2) with a 10-g force closed-coil spring. Phosphate-buffered saline, immunoglobulin G (IgG) isotype control antibody, or anti-SDF-1 neutralizing monoclonal antibody were injected at the M1 …

Effects Of ⍺-Lactalbumin Hydrolysate On Human Oral Squamous Cell Carcinoma Cell Lines, Agustina Putri Kintan Arini

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background : Alpha-lactalbumin, the protein from human and bovine milk has been found to be promising as an alternative of anticancer agent Objective: To investigate the effects of lactalbumin enzymatic hydrolysate (LAH) on cell proliferation, migration, and mRNA expression of MMP on human squamous cell carcinoma (hSCC) cell lines, in vitro. Materials and Methods: Tongue (HSC-4 and 7) and pharyngeal (HN-30 and 31) hSCC cell lines were treated with a two-fold dilution of LAH (0.39-100 mg/ml). Cell viability and cell proliferation were examined by MTT assay. Cell migration was investigated by a scratch wound healing assay. Gene expression of metastasis-associated …

Α-Glucosidase Inhibitors From Rhynchostylis Retusa, Winartiana -

Chulalongkorn University Theses and Dissertations (Chula ETD)

α-Glucosidase inhibitors are a group of anti-diabetic drugs that can help control blood sugar levels by hindering the breakdown of oligosaccharides and disaccharides into monosaccharides such as glucose, thus preventing intestinal absorption. Recent studies have shown that several plants in the Orchidaceae family produce secondary metabolites with α-glucosidase inhibitory activity. Rhynchostylis retusa, an orchid traditionally used for treating various diseases such as asthma, diabetes, and obesity, was investigated. The methanol extract of R. retusa showed significant inhibitory activity against the enzyme α-glucosidase, with 85.71% inhibition at a concentration of 100 µg/ml. The objective of this study was to isolate and …

Batch And Fixed-Bed Adsorption Of Ciprofloxacin Using Magnetic Biochar From Macadamia Nutshell, Sakonsupa Damdib

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this research, the utilization of macadamia nutshell as a potential adsorbent for ciprofloxacin (CIP) removal was investigated. The distinctive features of macadamia nutshell, characterized by its lignocellulosic composition and hardness, make it suitable as a precursor for synthesizing magnetic biochar, aimed at CIP adsorption in both batch and fixed-bed column processes. The influence of temperature activation and carbonization temperature on the properties of the resulting biochar was examined. Macadamia nutshell impregnated with a 0.10 M iron nitrate solution and carbonized under a nitrogen atmosphere at 800°C (MB-BI-800) exhibited the highest micropore and mesopore volumes, with values of 0.14 and …

Pharmacological Evaluation Of The Antirheumatic Activity Of Callicarpa Macrophylla Leaves Extracts By The Estimation Of Hepatic, Renal, And Inflammatory Markers, Harjinder Kaur, Ganesh N. Sharma, Mayur Bhurat

The Thai Journal of Pharmaceutical Sciences

Background: Callicarpa macrophylla is used in traditional medicine to treat many disorders including analgesic, antipyretic and anti-inflammatory. The aim of this study is to investigate the ethanolic and ethylacetate extracts of C. macrophylla leaves against rheumatoid arthritis (RA). Materials and Methods: Acute toxicity was studied in vivo to determine the toxic doses of the ethanolic and ethyl acetate extracts. Anti-rheumatic activity was also evaluated in vivo using formaldehyde and Complete Freund’s Adjuvant models in Wistar rats. After that paw volume was evaluated by the digital Vernier caliper and blood sample was taken by retro-orbital plexus route for the estimation of …

Characteristics And Metagenomic Profiles Of Antimicrobial Resistance In Bacterial Community From Airborne Dust In Pig Farm, Si Thu Hein

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study was to explore bacterial communities and antimicrobial resistance in airborne dust from pig farms. Airborne dust, pig feces, and feed were collected from nine pig farms (n=9) in Thailand, including Nakhon Sawan, Chainat, Supan Buri, Lopburi, and Saraburi, during the rainy season from May to October 2022. The farms were selected based on the owners' willingness to participate in the study and the availability of veterinarians or animal health practitioners. Airborne dust samples were collected at three different locations of the selected pig house, including upwind and downwind (25 m from pig house), and inside (at the center …

Writing The Literature Review, Robert Lloyd, Matthew Vollrath, Daniel Mertens

All Open Educational Resources

The purpose of this book is to help you write your next literature review. This is true whether you are crafting one for an undergraduate midterm paper, a doctoral dissertation, or working on your first manuscript for a peer review publication. For years, as professors we have read the best and worst of what students have written in our classes. We have witnessed in a handful of instances, undergraduate writers write more masterfully than doctoral students. We have witnessed doctoral students write first year papers which were ready for publication. And of course, the opposite is true. This begs, the …

Nine Black Women Leaders In The Academy: Promoters Of Constructive Disruption And Institutional Change, Natalie A. Johnson-Leslie, Kimberley M. Davis, Audrey D. Bowser, Hewlett Steve Leslie

Teacher Education Faculty Publications

This chapter explores nine Black women's formal and informal ways of leadership in the academy. Constructive disruptions by these nine Black women were based on their strong principles, values, and purpose as leaders. In addition, they initiated, managed, and overcame disruptions, including institutional oppression. Using the lens of intersectionality, critical race theory (CRT), and system justification theory, the researchers ground the documented constructive disruptions of instructional change of these nine Black women leaders. Document analysis of public records was used to determine the themes and tenets of these nine Black women's ways of leadership. Results showed that Black women are …

Disruption And Emergence: How To Think About Human Rights Futures, Austin Choi-Fitzpatrick

School of Peace Studies: Faculty Scholarship

This article suggests that humanity may be approaching a critical juncture, since a confluence of macro-historical changes might—individually or collectively—fundamentally transform the field of human rights, and usher in a second human rights era. In particular, it suggests that the confluence of tectonic geopolitical changes, system-wide shifts in climate and energy, and fundamentally new developments in science and technology might lead to a rupture of the same scale as the cluster of events that heralded the onset of the current rights regime. This argument builds on a number of literatures, especially those focused on norms cycles, rights generations, and what …

Mechanisms Of Education And Graded Sensorimotor Retraining In People With Chronic Low Back Pain: A Mediation Analysis, Aidan Cashin, Hopin Lee, Benedict Wand, Matthew K. Bagg, Edel O'Hagan, Rodrigo Rn Rizzo, Tasha Stanton, G. Lorimer Moseley, James Mcauley

Physiotherapy Papers and Journal Articles

An improved understanding of the biopsychosocial influences that contribute to and maintain pain has promoted the development of new efficacious treatments for chronic low back pain (CLBP). This study aimed to investigate the mechanisms of a new treatment—education and graded sensorimotor retraining—on pain and disability. We conducted a preplanned causal mediation analysis of a randomized clinical trial which allocated 276 participants with CLBP to 12 weekly clinical sessions of education and graded sensorimotor retraining (n = 138) or a sham and attention control (n = 138). Outcomes were pain intensity and disability, both assessed at 18 weeks. Hypothesized mediators included …

Multi-Chamber Silencer Composed Of Screw-Perforated Tubes And Straight-Perforated Tubes, Tian-Syung Lan, Min-Chie Chiu

Journal of Marine Science and Technology–Taiwan

The use of silencers to reduce noise is mandatory due to severe hearing damage caused by high venting noise in the engine room of ocean-going vessels. While straight and perforated tubes have been used as acoustical elements in traditional silencer design, studies have shown that the acoustical design still requires improvement. To enhance acoustical efficiency, the use of multi-chamber mufflers is proposed composed of screw and perforated tubes. Additionally, a mathematical finite element model built for acoustical simulation using the COMSOL program expedites the analysis of silencers with complicated acoustical elements. A sensitivity analysis of transmission loss concerning the geometric …

Rapid Species Identification Of Meretrix Lusoria And Three Other Meretrix Clams Using Pcr And Rflp Analysis Of The Mitochondrial Coii Gene., Chia-Hsuan Sung, Liang-Jong Wang, Chang-Wen Huang

Journal of Marine Science and Technology–Taiwan

Meretrix clams are among the most economically important species of bivalves in Eastern Asia and Taiwan. In the past, the identification of these hard clams depended on the shell morphology; however, species identification based on shell markings and shapes confuses the taxonomy of the Meretrix genus. The DNA molecular information is useful and can easily identify them accurately and quickly, especially the sequence of mitochondrial DNA. In this study, a PCR method to analyze the mitochondrial cytochrome c oxidase II (COII) gene was developed to rapidly identify of M. lusoria, M. lamarckii, M. lyrata and M. petechialis. Four different species …

Bearing Capacity Factor Characteristics Of Footings On Double-Layered Cohesive Soils, Chao-Ming Chi, Zheng-Shan Lin, Yu-Shu Kuo

Journal of Marine Science and Technology–Taiwan

In this study, the bearing capacity of a surface foundation resting on a double-layered cohesive soil profile was investigated by applying a rotational mechanism and finite-difference numerical simulations. The bearing capacity factor behaviors of a surface footing on double-layered cohesive soils can be classified and illustrated using a characteristic chart. Depending on the soil strata strength ratio and normalized layer thickness, the soil-foundation system can be in the squeezing, factor-increasing, factor-decreasing, or constant factor zones. The results indicated that the trend of the curves in the characteristic chart computed from the asymmetric failure mechanism was in accordance with that of …

Research On Ice Resistance Of Ships Sailing In Floating Ice Floe, Zhixin Xiong, Xinyuan Wu, Yang Li

Journal of Marine Science and Technology–Taiwan

To study the ice resistance of ships in areas with floating ice, the Xuelong 2 icebreaker was simulated. A floating-ice model was established using the discrete-element method, and an ice particle array was generated using MATLAB. The effects of ice coverage and speed on ice drag were studied From the numerical simulation results, it can be seen that there is a certain trend in ice resistance under different ice coverage ranges, which changes with the change of speed.By comparing with the empirical formula and the numerical value of the ship model test, this numerical simulation results are relatively accurate.It also …

The Pre-Processing Of Wt Blade Images By Ss And Bilateral Filter With Machine Learning Frameworks, Joy Iong-Zong Chen, Chien-Yeh Lee, Wien-Chieh Lo

Journal of Marine Science and Technology–Taiwan

This paper discusses the motivation behind turbine migration and addresses the challenges of using NN (neural network) computing systems. Moreover, it focuses on high-dimensional data from WT (wind turbine) blades. The three key aspects addressed in this study are turbine migration, overfitting, and strict feature selection. To evaluate the performance of the machine learning system, the study considers the characteristics of WT blades, specifically the similarity in blade color and the differences in shape. The authors apply pre-processing techniques, in particular a bilateral filter, in conjunction with the SS (selective synthesizer) of blade fouling patterns. The SS method adopts the …

The Prevalence Of Covid-19 Infection In Patients Having Autoimmune Or Chronic Inflammatory Rheumatic Diseases, Wessam Eissa Hamed

Journal of Medicine in Scientific Research

Objective : Patients who suffer from immune-mediated or chronic inflammatory rheumatic diseases show a varying likelihood of getting hospital-diagnosed COVID-19. This study helps to search the individual risk factors involved in COVID-19 susceptibility and to provide a basis to develop a better preventive recommendation to rheumatic patients. Methods: We conducted a retrospective cohort analysis with patients being monitored and followed up in Mataria Teaching Hospital`s rheumatology department. We compared newly updated datasets of adult rheumatology patients with positive PCR tests for COVID-19 that is conducted in the hospital and identified as having chronic inflammatory arthritis (IA), autoimmune or immune-mediated disease …

Saliva Pcr As A Simple Detector Of Covid- 19 In Patients With Acute Salivary Sialadenitis, Rasha Faisel Abu El Dahab, Mariam Adel Fouad

Journal of Medicine in Scientific Research

Background : Coronavirus 2019 (COVID-19) is caused by (SARS-CoV-2) a novel highly transmissible pandemic disease. It was noticed that there were many cases of acute salivary sialadenitis in the era of COVID -19 and not enough studies were documented. This study aimed to assess if there is a correlation between COVID -19 and acute salivary sialadenitis and assessed saliva PCR as an easy diagnostic test for COVID -19 also compared it with the gold standard nasopharyngeal swab PCR. Methods: A non-random observational study included 30 patients who had acute onset of salivary sialadenitis. They all underwent oropharyngeal, parotid and submandibular …

A Qualitative Study On The Financial Education Of Young Black Men, Sue M. May

University of the Pacific Theses and Dissertations

Financial literacy awareness is low among young adults, and financial literacy among Black college students is significantly lower than in other groups (Singh, 2018). However, there is little to no research on why financial literacy is so low among young Black men between 18 and 25. Few studies specifically show how financial literacy and decision-making may be related to their family economics and socialization for young Black men. Using Critical Race Theory and Family Financial Socialization theoretical frameworks, this dissertation project examined a sample of seven young self-identified Black men ages 24 to 25 years old in Northern California Bay …