Digital Commons Network^™

Data Collection In Advertising Through An Ethical Lens: The Argument For Consensual Collection, Megan Adams

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Investigating In Utero Vitamin D Supplementation To Reduce Early Neurodevelopmental Phenotypes In Mouse Models Of Rett Syndrome, Abigail Johnson

Renée Crown University Honors Thesis Projects - All

No abstract provided.

The Grave Concern That Is The United States Medicolegal Death Investigation System, Caitlyn Pritchard

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Fishing For Solutions: How Pre-Conceptional Fish Oil Supplementation In Obese Fathers May Mitigate Obesity-Related Inflammation And Non-Alcoholic Fatty Liver Disease In Their Children, Junhui Yang

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Norepinephrine-Induced Increases In Lactate Production By Hippocampal Astrocytes Are Stable During Aging, Monica Ciaffi

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Photoactivation Of Desmethylclozapine: Analyzing Serotonin Receptor Activity To Link Drug Use And Human Behavior, Michelle Shanguhyia

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Effects Of Hydrologic Connectivity And Species Difference On Riparian Popular Growth, Ryan Brinton

Renée Crown University Honors Thesis Projects - All

No abstract provided.

From Sanctions To Ceasefire: An Analysis Of The Variables That Contribute To Success For Sanctions Aimed At Peacekeeping, Claire Howard

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Addressing The Rural Doctor Shortage Through Influence Marketing, Louis Smith

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Deconstructing The Gender Enrollment Gap In Higher Education, Christopher Bezdedeanu

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Acknowledging A Stutter Impacts The Impression One Makes In A Job Interview, Jennifer Perez

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Feeding Obession: The Entangled Interconnectedness Of Social Media, Algorithms, Technology, And Eating Behaviors, Kaitlyn Jackmin

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Associations Between Family History Of Alcohol Use Problems And Drug Use And Undergraduage Students' Alcohol And Drug Use, Veronica Bucci

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Characterization Of Cell Type-Specific Molecular Heterogeneity In Cancer Using Multi-Omic Approaches, Min Kyung Lee

Dartmouth College Ph.D Dissertations

Tumors are composed of heterogeneous cell types each with its own unique molecular profiles. Recent advances in single cell genomics technologies have begun to increase our understanding of the molecular heterogeneity that exists in tumors with particular focus on gene expression and chromatin accessibility profiles. However, due to limitations in methods for certain sample types and high cost for single cell genomics, bulk tumor molecular profiling has been and remains widely used. In addition, other facets of single cell epigenomic profiling, particularly methylation and hydroxymethylation, remains underexplored. Thus, investigations to understand the cell type specific epigenetic heterogeneity and the cooperation …

Zinc Oxide Based Nanomaterials And Device Designs - For Bioenergy Harvesting, Sensing And Water Purification, Congran Jin

Dartmouth College Ph.D Dissertations

Biomechanical energy harvested from the human body can power implantable electronics such as cardiac pacemakers, replacing conventional batteries and offering a lifelong energy solution. The electrical signals converted from biomechanical motions contain vital physiological information, making them suitable as a sensor to monitor one's health condition. Zinc Oxide (ZnO) is a versatile material with various intriguing properties, including piezoelectricity, photo-catalytic and piezo-catalytic properties. This thesis aims to exploit and enhance these properties of ZnO by rationally designing its nano- and micron-structures and employing them, along with other functional materials, in the development of novel biomechanical energy harvesting, water purification, and …

100 Years Of International Ip - Reflections On Past, Present And Future, Frederick M. Abbott

Scholarly Publications

We have been asked to reflect on the past 100 years of international intellectual property law and to try to project forward about what changes might be necessary or desirable in the future. Only a science fiction writer would purport to have some idea about what things might look like a hundred years in the future, including from the standpoint of international intellectual property, so my remarks on that will be somewhat more proximate to the present.

Public Profiteering Of Prison Labor, Tiffany Yang

North Carolina Law Review

No abstract provided.

The ‘Homework Gap’ And Academic Achievement In High School Science: An Ecological Perspective For Policymakers And Practitioners, Tianca Crocker, David Kleitsch

National Youth Advocacy & Resilience Journal

Information and communication technologies (ICTs) are increasingly required within K-12 educational settings, yet the impact of youth’s access to and use of digital resources outside of the classroom on academic achievement is only beginning to be explored in the literature. This study used data from the Fragile Families & Child Wellbeing Study to assess the relationship between grades in high school science and digital equity across the learner’s ecological environment. Digital inequities experienced by school-aged youth are referred to as the homework gap. The COVID-19 pandemic placed new urgency on resolving the homework gap as millions of students shifted to …

Parent Education: A Key Aspect In Prevention And Intervention Of Bullying In School Communities, Kanessa M. Doss, Sherrionda H. Crawford

National Youth Advocacy & Resilience Journal

Bullying continues to be an omnipresent public health issue in school communities, affecting children’s and adolescent’s academic success, socio-emotional well-being, and overall development. Schools play a fundamental role in addressing bullying, yet parent and community involvement is equally critical. This article explores the significance of parent education in bullying prevention and intervention within school communities. The role of schools and community stakeholders with implications for each group are discussed. Resources are provided to share with parents/caregivers and facilitate their involvement in anti-bullying initiatives within school communities. The authors offer recommendations for school communities to promote anti-bullying awareness, facilitate parent education …

Microdebris Abundance, Distribution, And Ingestion By Sargassum-Associated Juvenile Fishes In The Gulf Of Mexico, Olivia L. Lestrade, Frank Hernandez

Gulf and Caribbean Research

Holopelagic Sargassum is a critical nursery habitat for the early life stages of many marine fishes, including several federally managed species in the United States and Caribbean. Sargassum is often aggregated along surface convergence features where microdebris (synthetic, semi—synthetic, and naturally—derived particles size) have also been found in relatively high concentrations. In this study, we collected microdebris from Sargassum and adjacent open water habitats (in 2018), and juvenile fishes from Sargassum (in 2017 and 2018) in the northern Gulf of Mexico to quantify habitat—specific microdebris concentrations and the degree to which Sargassum—associated juvenile fishes ingest microdebris. Microdebris concentrations within …

A Miocene Nannofossil Biostratigraphic Case Study: Alaminos Canyon Block 627 And Mississippi Canyon Block 555, And Sedimentation Rates In The Gulf Of Mexico, Bethany L. Cobb Faulk, Murlene W. Clark

Gulf and Caribbean Research

The Miocene sediments of 2 deep—water boreholes from the northern Gulf of Mexico, from Alaminos Canyon (AC) Block 627 and Mississippi Canyon (MC) Block 555, have been biostratigraphically analyzed using calcareous nannofossils, revealing changes in sedimentation rates and depositional environments between these 2 areas. High nannofossil abundance values and low sedimentation rates generally recorded in the Alaminos Canyon region suggest a condensed section during much of the Miocene, associated with a basinal environment. Mississippi Canyon exhibits lower nannofossil abundance and higher sedimentation rates compared to Alaminos Canyon during the majority of the Miocene. Increased sediment volumes are largely attributed to …

Pancreatic Ductal Adenocarcinoma And New Treatments In Development, Melissa J. Moisan

Biology and Microbiology Graduate Students Plan B Research Projects

Pancreatic ductal adenocarcinoma (PDAC) is the most frequently mutated (95%) 5exocrine pancreatic cancers. Patients with PDAC are also the least likely to survive more than 5 years with only 8% overall survivability. The median survival for patients with distant metastasis is less than one year. Most pancreatic ductal adenocarcinoma occurs in the pancreatic head, and the remainder can be found within the body (5% to 15%) or tail (10% to 15%) (14). This extremely aggressive cancer has an increasingly large metastatic dissemination rate to surrounding organs such as the liver, lung, and peritoneum, or can be seen as distant metastases …

Role Of Histone Deacetylases In Regulation Of Macrophage Phagocytosis Of Mycobacterium Tuberculosis, Benjamin Esiesimua

Biotechnology Theses

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global health emergency. Macrophages are critical in protection against TB by phagocytosis of Mtb. Although histone deacetylases (HDACs), are critical in macrophage differentiations, their roles in macrophage phagocytosis of Mtb remain unexplored. To explore this, I first established human monocyte derived macrophages (MDMs) phagocytosis of red zymosan beads. MDM phagocytosed zymosan beads at 37°C in a dose dependent manner in contrast to suppressed phagocytosis by the MDMs incubated with beads at 4°C or in the presence of cytochalasin D, actin polymerization inhibitor. Incubation of MDMs with 11 zinc-dependent HDAC inhibitors did …

Undergraduate Bulletin, 2023-2024, Minnesota State University Moorhead

Undergraduate Bulletins (Catalogs)

No abstract provided.

Comments On U.S. Funding For Ghg Corporate Reporting Standardization, Columbia Center On Sustainable Investment, Sabin Center For Climate Change Law

Columbia Center on Sustainable Investment

The Columbia Center on Sustainable Investment (“CCSI”) and the Sabin Center for Climate Change Law (“Sabin Center”) are pleased to submit our joint comments on how appropriations made to the Environmental Protection Agency (“EPA”) under the Inflation Reduction Act of 2022 (“IRA”) can best be used to enhance the agency’s efforts to standardize corporate climate commitments, improve transparency around greenhouse gas reductions, and accelerate progress towards decarbonization in the corporate sphere. This Comment focuses on the funding provided to the EPA under Section 60111, on Greenhouse Gas (“GHG”) Reporting.

Net Zero Roadmap For Copper And Nickel, Columbia Center On Sustainable Investment, Carbon Trust, Rmi, Payne Institute For Public Policy

Columbia Center on Sustainable Investment

As we seek to meet the challenges of climate change impacts, many commodities will play an increasing role in decarbonizing economies. There are increasing challenges of addressing the emissions from extraction of these commodities needed to support the zero-carbon transition.

CCSI, in a consortium with Carbon Trust, RMI, and the Payne Institute for Public Policy at the Colorado School of Mines, developed the Net Zero Roadmap to 2050 for Copper and Nickel Value Chains to support the copper and nickel mining sectors in taking collective, coordinated action by providing a clear, approachable, and accepted roadmap for decarbonization.

Our key messages …

Arginine-178 Is An Essential Residue For Itpa Function, Nicholas E. Burgis, Caitlin April, Kandise Vanwormer

Chemistry and Biochemistry Faculty Publications

The inosine triphosphate pyrophosphatase (ITPA) enzyme plays a critical cellular role by removing noncanonical nucleoside triphosphates from nucleotide pools. One of the first pathological ITPA mutants identified is R178C (rs746930990), which causes a fatal infantile encephalopathy, termed developmental and epileptic encephalopathy 35 (DEE 35). The accumulation of noncanonical nucleotides such as inosine triphosphate (ITP), is suspected to affect RNA and/or interfere with normal nucleotide function, leading to development of DEE 35. Molecular dynamics simulations have shown that the very rare R178C mutation does not significantly perturb the overall structure of the protein, but results in a high level of structural …

Targeting The Pai-1 Mechanism With A Small Peptide Increases The Efficacy Of Alteplase In A Rabbit Model Of Chronic Empyema, Galina Florova, Christian J. De Vera, Rebekah L. Emerine, Rene A. Girard, Ali Azghani, Krishna Sarva, Jincy Jacob, Danna E. Morris, Mignote Chamiso, Steven Idell, Andrey A. Komissarov

School of Medical and Biological Sciences Faculty Publications and Presentations

The incidence of empyema is increasing and associated with a mortality rate of 20% in patients older than 65 years. Since 30% of patients with advanced empyema have contraindications to surgical treatment, novel, low-dose, pharmacological treatments are needed. A Streptococcus pneumoniae-induced rabbit model of chronic empyema recapitulates the progression, loculation, fibrotic repair, and pleural thickening of human disease. Treatment with single chain (sc) urokinase (scuPA) or tissue type (sctPA) plasminogen activators in doses 1.0–4.0 mg/kg were only partially effective in this model. Docking Site Peptide (DSP; 8.0 mg/kg), which decreased the dose of sctPA for successful fibrinolytic therapy in acute …

A Job Guarantee: Student Ideas, Zdravka Todorova, Shannon Parisi, Patrick Lockhart, Brad Kerry, Jeremy A. Ocampo, Divya Sharma, James Curlis, Tristan Walters

Student Papers in Local and Global Regional Economies

This paper presents students’ ideas for job guarantee public service projects, developed in a Master's level course, Economic Social and Ecological Systems. Seven student proposals address local issues and their economic, social, and ecological aspects. The proposals build on social costs, stratification, and commodification; and identify locally needed public service jobs not provided by the business sector. As part of a federally funded, locally designed, and administered job guarantee program, they expand and improve public and non-profit sectors. The article describes the course and its focus on integrated systems, as well as the pedagogy of building on students’ interests, concerns, …

Festival Of Research Abstracts, 2023, College Of Science And Mathematics, Wright State University

Festival of Research

The collection of abstracts accepted for the 2023 Festival of Research hosted by the Wright State University College of Science and Mathematics.