Digital Commons Network^™

Expression Of Htyr In Drosophila As A Novel Model Of Parkinson’S Disease, Madeleine Callan

Scripps Senior Theses

Parkinson’s disease is a debilitating and often deadly neurodegenerative disease affecting a growing and large population. Its etiology has long remained elusive, and because no other organisms have Parkinsonian-like diseases, it is difficult to study PD using model organisms. Neuromelanin (NM), an insoluble melanin synthesized in the dopaminergic synthesis pathway in DA neurons, has recently been implicated in PD as a major causal factor. At high levels in DA lysosomes, it functions as a proteostatic pathway inhibitor–blocking dopaminergic neurons from breaking down harmful molecules until the lysosomes eventually degenerate as well as triggering autophagy, inflammation, and total neurodegeneration. Recently, neuromelanin …

The Clinical Utility Of The Brief-2 Emotional Regulation Index (Eri) In Predicting Psychiatric Disorders Comorbid With Pediatric Adhd, William Alexander Anastasiadis

All-Inclusive List of Electronic Theses and Dissertations

Recent research suggests that consideration of emotional regulation (ER) may help assess psychiatric disorders that commonly co-occur with attention-deficit/hyperactivity disorder (ADHD). In clinical settings, ER in youth is typically assessed using an informant report such as the Behavioral Rating Inventory of Executive Function (BRIEF). Advances in psychometric assessments, such as the recently updated BRIEF-2, assist clinicians in diagnosing conditions comorbid with ADHD. There is little research on the BRIEF-2, with even less considering the new Emotional Regulation Index ( ERI ) on the BRIEF-2. The present study examined the clinical utility of the BRIEF-2 ERI and its associated scales in …

Trait Self-Control, Ego-Depletion, And Mental Health In Non-Offending Minor Attracted Persons, Amaya Kathia Bonilla

All-Inclusive List of Electronic Theses and Dissertations

Research has focused on understanding the offending behavior of minor attracted persons (MAPs) due to the negative impact their behaviors have on some of the most vulnerable members of society. Further, many different models of impulsivity have been developed to explain these offending behaviors. However, limited research focuses on non-offending MAPs and gaining knowledge about what prevents them from offending. The present study attempted to fill this gap by exploring the relationship between trait self-control and ego-depletion on expression of sexual words. Additionally, the relationship between trait self-control and mental health was assessed. The present study utilized a survey approach …

Oral Contraceptives And Affective Disorders: Neurobiology And Informed Choice, Sophia Mae Drezner

Scripps Senior Theses

Pregnancy prevention and female reproductive freedom have been some of the most contested political issues for decades. Abortion, a fundamental part of women’s healthcare, divides liberals and conservatives on an international scale. The consequences of unintended pregnancy without safe and reliable contraception are widespread, disproportionately impacting women of color, trans and non-binary folks, and poorer communities. The birth control pill is the most common form of oral contraception (OC) globally. Many people with ovaries begin the pill or other hormonal contraceptive (HC) methods as young as 11 years old. Exogenous progesterone and estrogen are known to impact mood, affect, physiology, …

Cultivating Carrots, Community, And Health-Conscious Children: Investigating The Effects Of Community Garden Implementation On Nutrition Attitudes Of Elementary Students In The Los Angeles Unified School District, Hannah Michele Tiedemann

Scripps Senior Theses

Growing up in an urban food desert can significantly affect children's development, health, and well-being (Jencks et al., 1990; Leventhal et al., 2000). Compared to their more affluent peers, youth living in low-socioeconomic urban neighborhoods are at greater risk of experiencing poor-quality diets, food insecurity, unhealthy body weights, and mental health problems (Duncan et al., 1997; Sampson et al., 1997). Moreover, children living in food-insecure households are more likely to consume calorically dense diets high in trans fat and added sugar, putting them at risk for poor health, childhood obesity, and chronic, diet-related diseases as adults (Nielsen et al., 2002). …

Music Therapy: Structural Music Modulation On Reducing Symptoms Of Generalized Anxiety Disorder., Isha Kaur Singh

Scripps Senior Theses

The present study examines whether modulating musical structural elements in therapeutic treatment reduces the severity of symptoms among individuals diagnosed with generalized anxiety disorder. Music therapy has recently become a more utilized non-traditional treatment modality for anxiety. However, the specific elements of music that trigger relaxation responses alongside prevent rumination spirals has not received significant attention in literature thus far. This study aims to assess what type of music allows for the most effective treatment in reducing anxiety. Using a 2 (tempo: adagio, allegro) x 2 (timbre: string instrumental, vocal) x 2 (key: C major, D minor) between participants experimental …

Longitudinal Effects Of Prenatal Teratogen Exposure On Executive Function And Academic Outcomes, Dawn Michele Moore

CGU Theses & Dissertations

The healthy development of executive function in adolescents is essential for controlling attention and behavior, especially as children confront the challenges associated with puberty, social situations, parental pressures, academic pursuits, and the transition to adulthood. For children prenatally exposed to teratogenic substances (i.e., certain prescription medications, maternal infections or conditions, alcohol, tobacco, etc.), higher-order cognitive skills may be compromised, resulting in an increased risk of delayed developmental functioning, deficits in cognitive and executive functioning, and poorer academic outcomes. Research findings suggest that even low-to-moderate levels of alcohol and/or tobacco use during pregnancy are associated with poorer academic performance, lower IQ …

The Development Of Adolescent Students’ Self-Directed Learning Skills Within A Montessori Program During Covid-19: A Longitudinal Mixed-Methods Study, Elyse Laurelle Postlewaite

CGU Theses & Dissertations

Students who develop and apply their self-directed learning skills have advantages in school over those who do not (Betts & Knapp, 1981; Candy, 1991; Guglielmino, 1977; Schunk & Zimmerman, 2012). This is because self-directed learning (SDL) skills enable autonomous learning where students self-initiate, solve problems, develop new ideas, and monitor themselves with minimal external guidance (Knowles, 1976; Zimmerman, 2000). Despite the importance of these skills, research shows that few students consistently engage in SDL (Dent & Koenka, 2016; Zimmerman & Schunk, 2001). Because of SDL's multi-faceted and complex nature, it is difficult to discern why this is the case (Dent …

Cyclic Di Amp Level In Various Mutants And Clinical Isolates Of Streptococcus Pyogenes, Tasmim Hossain

All-Inclusive List of Electronic Theses and Dissertations

Streptococcus pyogenes is a Gram-positive aerotolerant bacterium that is an extracellular, non-motile, non-sporulating pathogen. They are clinically important in humans not only because of their pathogenicity but their remarkable ability to adapt to harsh conditions. Viability and virulence of S. pyogenes are reported to be associated with cyclic-di-adenosine monophosphate (c-di-AMP). Proper biosynthesis of this second messenger is essential to maintain ionic balance, homeostasis and cell envelope integrity as it has been reported to be associated with the expression of the virulence factors SpeB which the pathogens use to fight the host immune system leading to infection development. c-di-AMP helps S. …

Indigenous Storytelling As Decolonial Praxis, Ceremony And At Colby, Georgia Goodman

Honors Theses

This thesis seeks to amplify Indigenous lifeways, diplomacies, sciences, diplomatic relations, and the power of storytelling. This is not a piece analyzing Indigenous culture. Rather, this thesis returns the gaze to the settler colonial state, specifically its storytelling ideologies, to show that systemic practices of inequity in storytelling can be disrupted and decolonized through a recentering of Indigenous ideologies. For example, reciprocity with lands and animals, reflection on positionality and decentering colonial understandings of time and place.

Does Tssh Deletion In Paraburkholderia Bonniea Affect Its Symbiosis With Dictyostellum Discoideum?, Anna Chen

Honors Theses

Paraburkholderia are amoeba resistant, gram negative bacteria that form facultative symbiotic relationships with D. discoideum, a soil dwelling amoeba host. Three species of Paraburkholderia, P. agricolaris, P. hayleyella, and P. bonniea are able to persistently infect nonnative, or symbiont free, D. discoideum. These three species share a type III secretion system (T3SS) and type VI secretion system (T6SS) that is absent in other close relatives We hypothesized that the ability to persistently infect D. discoideum may be partially attributed to the T3SS and T6SS shared across the three species of Paraburkholderia.

The goal was to test the phenotypic effect of …

Changes In Ecosystem Processes And Functional Traits Over An Elevational Gradient, Tiana Issa

Honors Theses

Elevation gradients have been used to understand how climate change impacts various ecosystems processes by substituting distance across elevation with time, reflecting a previous, colder climate. To monitor the changes in soil organic carbon (SOC), plant community, and functional traits across time in the face of climate change, this study used space-for-time substitution to emulate a long-term study with elevational gradients and revisited the same gradient for nearly two decades to monitor elevational effects across time. With this research, I aim to answer the following questions: (1) How does elevation impact ecosystem processes and alpine plant traits? (2) How does …

Pluralistic Ethical Personalism, Qifan Hu

Honors Theses

In the thesis, I sketch out a general outline for a pluralistic, personalist theory of ethics. This theory intends to capture the phenomenon that our life experience is saturated with ethical and other kinds of values; and it also emphasizes the idea that each ethical agent, or human being, has a unique ethical project that is understandable in light of various ethical values.

The Effect Of Blue Mussel (Mytilus Edulis) Extinction On Ecosystem Function In The Gulf Of Maine Rocky Intertidal, Sophia K. Montague

Honors Theses

Stressors associated with climate change including thermal stress and ocean acidification inhibit the growth and reproduction of many species, including the ecologically and economically important blue mussel species in the Gulf of Maine (GOM). Established scaling relationships between mussel size, abundance, and water filtration suggests that the decline of mussels will stunt GOM water filtration. This change in the rate of water filtration could have large effects on the abundance of phytoplankton, abundance of invertebrate larvae, abundance of nutrients and organic material, food web stability, and biodiversity. Overall, this thesis explores the effect of blue mussel (Mytilus edulis) …

Finding The Common Denominator: Understanding The Shared Experiences Of Female Math Majors, Abigail R. Rosenbaum

Honors Theses

Despite efforts to increase gender diversity in STEM fields, women remain underrepresented in mathematics, especially in advanced academic and research positions. This study aimed to explore the experiences of female math majors as they attempt to navigate this male-dominated space. Through qualitative interviews with seven female math majors, two female math professors, and a focus group with education majors at Woodbridge College, small liberal arts college in the United States, several common themes were identified that define the experiences of female math majors. The findings suggest that math is held at an elevated status in society and that there is …

Tracing North Atlantic Continental Erosion Events During The Mid-Pleistocene Transition, Cecilia T. Bowe

Honors Theses

The Mid-Pleistocene Transition (MPT), which occurred between 1.2 and 0.7 Mya, is characterized by changes in the periodicity and intensity of glacial-interglacial cycles. Early research into this event found that it was not triggered by changes in orbital forcing, but rather by internal climate processes. Previous studies have constrained a probable two-step mechanism, in which erosion of regolith under ice sheets increased glacial volumes and contributed to increased carbon sequestration in the Southern Ocean. Additional research has built on this, suggesting that increased glacial erosion of cratons surrounding the North Atlantic preceded a major weakening of the Atlantic Meridional Overturning …

Testing Evolutionary Conservation Of Sex Determination In Lepidoptera Using Crispr/Cas9 Gene Editing, Sophia Schroeder

Honors Theses

The mechanism of sex determination in Lepidoptera is largely unexplored, and limited to knowledge of only a few genes. Adult Lepidoptera have obvious sexually dimorphic qualities, such as their genitalia. However, significant sex determination genes are not imperative for the adult developmental stage. Knockouts of some sex determination genes (doublesex isoforms) are shown to be lethal in the embryonic and larval stages of development in several animals. However, it is unclear whether this is due to their respective impact on sex determination and sexual dimorphism, or the existence of another function, such as pleiotropy, within a particular gene. Moreover, …

Food As A Vector For Change: Lessons From The Third Sector On Improving Livelihoods With Nutritional Knowledge In Medellín And Bogotá, Solomon Treister

Honors Theses

In this thesis I argue that improving diet in communities depends on building nutritional knowledge. In examining the role of community level organizations, I look specifically at how knowledge is conveyed through agriculture and gastronomy. This project analyzes how civil society organizations work to reintegrate individuals into food systems, compelling consumers to take agency over their diets and pursue better livelihoods. The industrialization of food systems has fundamentally changed the way humans connect with food and diet. In Colombia, internal displacements and urban migration have accelerated a loss of connection with the land and food processes. At the same time, …

Examining The Impact Of Living Arrangements On Children's Academic Achievement, Rachel G. Coan

Honors Theses

In my paper I examine how different living arrangements impact how well a child performs in school. The living arrangements are: living with both biological parents, living with biological mother, and living with biological father. Using a linear regression method, I regress living arrangements against GPA and find that children who do not live with both of their biological parents are expected to perform about 0.3 GPA points worse in school than children who do. With added control variables the difference in predicted GPAs decreases. Additionally, I find that living arrangements aren’t predicted to impact children differently depending on their …

Trends In Cyanotoxin Production Potential In China Lake: An Edna Analysis Of Microcystis And Dolichospermum And The Environmental Drivers Of Cyanotoxin Production, Gennifer M. Rubin

Honors Theses

Episodes of cyano-harmful algal blooms (cyano-HABs) are hypothesized to be exacerbated by the effects of climate change. However, the dynamics of the interactions between elements of climate change and toxigenic cyanobacteria proliferation are not well defined. China Lake is the drinking water source for 7 municipalities in the Kennebec County and is one of many lakes in central Maine that has been subjected to high levels of cyano-HABs and microcystin toxin contamination in recent years. Monitoring the toxicity of these blooms in relation to various aspects of climate change may lead to identification of the major drivers of microcystin production …

Biomechanics Of Mantis Prey Capture, Danielle S. Taylor

Honors Theses

Mantis species have a variety of different morphologies, so do the extreme forms of mantis limbs trade prey catching capability for camouflage? We hypothesize that some extreme forms of mantis limbs that are associated with cryptic species may be associated with a tradeoff of the capability of those limbs. Previous research has developed 2D morphologies of several hundred species of mantises. We are creating a 3D morphology by using micro dissection, micro CT imaging to construct our 3D biomechanical model. We found the attachment points of the ligaments and muscles from a Tenodera forearm and have constructed a 2D biomechanical …

Natural Gas And Net Zero: Mutually Exclusive Pathways For The Southeast, Adam D. Orford

Faculty Scholarship

Climate policy increasingly focuses on pathways to achieving net zero greenhouse gas emissions by 2050, providing a clear standard against which to evaluate energy system planning. Examining the current and projected fuel mix of the electric power sector in the southeastern United States shows that an ongoing transition to natural gas for electricity risks locking in decades of greenhouse gas emissions at levels fundamentally incompatible with net zero goals. Furthermore, southeastern regulatory proceedings are not well designed to engage with this reality, although useful regulatory models are emerging. Natural gas will remain an important part of the southeastern fuel mix …

Goal Concordance In Rheumatoid Arthritis Patients With Depression – What Do Patients Prioritize?, Allison Schue, Md

Articles, Abstracts, and Reports

2023-2024 PGY3

Volume 35 - From Subsidiarity To Peace On Earth: Another Approach To Synodality, The Ecumencial Association Of Nigerian Theologians

Bulletin of Ecumenical Theology

Volume 35 of The Bulletin of Ecumenical Theology is available for purchase by contacting Dr. Peter Osuji at Duquesne University. After two years, issues are made freely available through the Duquesne Scholarship Collection.

Editorial (p.5)

Ecumenical and Interfaith Environmentalism in Nigeria: Path to Environmental Sustainability and Peaceful Society, Chidiebere Obiodu (p.6)

Fratelli Tutti: Islamic And Christian Religious Education In Nigeria, Patricia E. Idoko (p.35)

The Christian Association of Nigeria, Violence and Insecurity: Responses from the Christian Council of Nigeria, Vincent A. Olusakin & Clifford Meesua Sibani (p.53)

The Living Faith of the Dead and the Dead Faith of the Living: …

The Effects Of Rootstocks On Growth And Development Of Sour Cherry (Prunus Cerasus L. Cv. "Kütahya") In The Growing Conditions Of Bursa, Mevlüt Batuhan Koşar, Di̇lan Ahi Koşar, Ümran Ertürk

Turkish Journal of Agriculture and Forestry

Turkey is one of the most important sour cherry (Prunus cerasus L.) producers in the world, mostly producing the cultivar "Kütahya." To date, no previous study published on the effects of clonal roodstocks on the growth and development, yield, and fruit quality of ?Kütahya? sour cherry. Therefore, this study was carried out from 2015 to 2019 to determine the influences of SL-64, Piku 3, Maxma 14, CAB 6P and PHL-C rootstocks on vigor, yield, and fruit quality of "Kütahya" sour cherry cultivar in Bursa, Marmara Region, Turkey. The effects of rootstocks on blooming period, ripening time, trunk diameter, trunk …

Cover And Contents

Turkish Journal of Agriculture and Forestry

No abstract provided.

Determination Of Kinetic Parameters For Bone Turnover In Chronic Kidney Disease With Hemodialysis Patients Using Dynamics 18f-Naf Pet/Ct Imaging, Viyada Sanoesan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bone turnover measurement using 18F-NaF PET/CT serves as a valuable imaging biomarker for studying bone metabolism at various sites of skeleton. This study aimed to determine the kinetic parameters (Ki–Patlak) for bone turnover prediction as a non-invasive biomarker from dynamic 18F-NaF PET/CT in chronic kidney disease (CKD) patients with hemodialysis. Moreover, we aimed to investigate whether Ki–Patlak derived from shortened scan time can provide a prediction equivalent to that obtained from routine dynamic scan. Twenty-seven Thai CKD patients on hemodialysis (48 scans) from December 2021 to December 2023 were recruited. After intravenous injection of 18F-NaF of 133±39.3 MBq, dynamic PET/CT …

การตรวจวัดระดับ Lipoprotein(A) และการประเมินความเสี่ยงต่อการเกิดโรคหลอดเลือดหัวใจโดยใช้เครื่องตรวจจอตาปัญญาประดิษฐ์แบบพกพาในผู้ป่วยไทยที่เป็นโรคหลอดเลือดหัวใจที่ได้รับการสวนหลอดเลือดหัวใจ, พิทวัส โอวรากร

Chulalongkorn University Theses and Dissertations (Chula ETD)

ที่มา: Lipoprotein(a) หรือ Lp(a) เป็นหนึ่งในปัจจัยสำคัญที่ทำให้เกิดโรคหลอดเลือดหัวใจ โดยระดับของ Lp(a) ขึ้นกับพันธุกรรมเป็นหลักและพบว่าระดับแตกต่างกันในแต่ละเชื้อชาติ นอกจากนั้นปัจจุบันมีวิธีการตรวจความเสี่ยงต่อการเกิดโรคหลอดเลือดหัวใจด้วยการถ่ายภาพจอตาร่วมกับการใช้ปัญญาประดิษฐ์ ข้อมูลเกี่ยวกับระดับ Lp(a) ในผู้ป่วยโรคหลอดเลือดหัวใจชาวไทยยังค่อนข้างจำกัด รวมไปถึงยังไม่เคยมีการศึกษาเกี่ยวกับการประเมินความเสี่ยงต่อการเกิดโรคหลอดเลือดหัวใจในอนาคตด้วยการใช้ภาพถ่ายจอตาปัญญาประดิษฐ์มาก่อน วัตถุประสงค์: ศึกษาความแตกต่างระหว่างระดับ Lp(a) ในผู้ป่วยชาวไทยที่เป็นโรคหลอดเลือดหัวใจและผู้ป่วยที่ไม่เป็นโรคหลอดเลือดหัวใจและเพื่อหาค่าเกณฑ์ตัดสินผลบวก (cut-off) ที่ได้จากการใช้เครื่องตรวจจอตาปัญญาประดิษฐ์ที่สามารถนำมาใช้ทำนายการเกิดโรคหลอดเลือดหัวใจได้ วิธีการศึกษา: คัดเลือกผู้ป่วยที่เข้ารับการสวนหลอดเลือดหัวใจที่โรงพยาบาลจุฬาลงกรณ์ สภากาชาดไทย เดือนมกราคม พ.ศ. 2567 ถึง เมษายน พ.ศ. 2567 ผู้เข้าร่วมวิจัยจะถูกแบ่งเป็นสองกลุ่มตามผลการสวนหลอดเลือดหัวใจ ได้แก่กลุ่มผู้ป่วยที่เป็นโรคหลอดเลือดหัวใจและกลุ่มผู้ป่วยที่ไม่เป็นโรคหลอดเลือดหัวใจ ผู้เข้าร่วมวิจัยทุกรายจะได้รับการเจาะเลือดเพื่อส่งตรวจระดับ Lp(a) และได้รับการตรวจภาพถ่ายจอตาด้วยเครื่องตรวจจอตาปัญญาประดิษฐ์ ผลการวิจัย: ผู้เข้าร่วมวิจัยได้รับการสวนหลอดเลือดหัวใจจำนวน 120 ราย แบ่งเป็นผู้ป่วยที่ไม่เป็นโรคหลอดเลือดหัวใจ 40 รายและผู้ป่วยที่เป็นโรคหลอดเลือดหัวใจจำนวน 80 ราย สำหรับวัตถุประสงค์หลักของการศึกษาพบว่าค่ามัธยฐานของระดับ Lp(a) ในกลุ่มผู้ป่วยที่ไม่เป็นโรคหัวใจเท่ากับ 16.6 นาโนโมลต่อลิตร ค่าพิสัยระหว่างควอไทล์ 8.5 ถึง 33.7 ส่วนกลุ่มผู้ป่วยที่เป็นโรคหลอดเลือดหัวใจ มีค่ามัธยฐานของระดับ Lp(a) เท่ากับ 30.3 นาโนโมลต่อลิตร ค่าพิสัยระหว่างควอไทล์ 15.5 ถึง 88 โดยมีความแตกต่างอย่างมีนัยสำคัญทางสถิติ (p-value

การประเมินประสิทธิภาพของอาคารเขียว: กรณีศึกษาในกรุงเทพมหานครและปริมณฑล, นภัสสร แพรกอุดม

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยฉบับนี้มีจุดประสงค์เพื่อประเมินประสิทธิภาพด้านคุณภาพของสภาวะแวดล้อมภายในอาคารของอาคารเขียวและอาคารสำนักงานทั่วไปในกรุงเทพมหานครและปริมณฑล และประเมินค่าใช้จ่ายด้านการใช้พลังงานของระบบระบายอากาศและระบบปรับอากาศภายในอาคาร โดยดำเนินการตรวจวัดทั้งเชิงวัตถุวิสัยและตรวจวัดเชิงอัตวิสัย ภายในอาคารเขียว 3 อาคาร และอาคารสำนักงานทั่วไป 1 อาคาร โดยใช้เครื่องมือตรวจวัดคุณภาพอากาศภายในอาคารและแบบสอบถาม จากการศึกษาแสดงให้เห็นว่ามีความแตกต่างกันของผลการตรวจวัดอย่างมีนัยสำคัญหว่างอาคารเขียว และผลการตรวจวัดในบางอาคารเกินค่าเฝ้าระวังฯ โดยเฉพาะ PM2.5 (16.67-40.26 µg/m3) เนื่องจากมลพิษภายนอกอาคารและพฤติกรรมของผู้ใช้อาคาร ผลจากแบบประเมินแสดงให้เห็นว่าผู้ใช้อาคารส่วนมากพึงพอใจกับคุณภาพของสภาวะแวดล้อมโดยรวม ส่วนข้อมูลผลกระทบทางสุขภาพวิเคราะห์โดยใช้ Odd Ratio พบว่า ผู้ใช้อาคารที่มีระดับมลพิษสูงมีโอกาสเกิดอาการทางสุขภาพมากกว่าผู้ใช้อาคารที่ได้รับสัมผัสในระดับที่ต่ำกว่า ในส่วนของค่าไฟฟ้าจากระบบปรับอากาศ อาคารสำนักงานทั่วไปมีค่าสูงที่สุดเมื่อเปรียบเทียบกับอาคารเขียว โดยการบริหารจัดการอาคารที่ไม่เหมาะสมและนโยบายการประหยัดพลังงานที่ไม่มีประสิทธิภาพอาจส่งผลกรทบต่อคุณภาพของสภาวะแวดล้อมภายในอาคารให้แย่ลงได้ โดยสรุป คุณภาพอากาศภายนอกอาคารและพฤติกรรมของผู้ใช้อาคารเป็นปัจจัยสำคัญที่ส่งผลกระทบต่อประสิทธิภาพของอาคารในด้านคุณภาพของสภาวะแวดล้อมภายในอาคารของอาคารเขียวได้

Molecular Characterization And Biosynthesis Of Izumo1 And Juno In Domestic Cats (Felis Catus), Phakjira Sanguansook

Chulalongkorn University Theses and Dissertations (Chula ETD)

The negative impacts of domestic cat overpopulation and the limitations of currently available methods to induce infertility in cats necessitate the development of novel targets for non-surgical contraception in this species. The recent discovery of IZUMO1-JUNO, a pair of sperm-oocyte proteins that are both indispensable for the fertilization process, inspires the targeting of them for contraception in cats. To gain insight into feline IZUMO1 and JUNO, this thesis aims to identify 1) the target organs expressing IZUMO1 and JUNO in domestic cats 2) the expression of feline IZUMO1 during epididymal sperm transit in the epididymis and feline JUNO during various …