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Nutritional And Wellness Strategies For Neurological And Psychiatric Recovery From Postcovid Syndrome And Post-Acute Sequelae Of Covid-19, Jeffrey Schaefer, Deepesh Khanna

HPD Articles

The post-COVID syndrome was officially recognized as a disability under the Americans with Disabilities Act, indicating that this syndrome has made a significant impact on our populace. Also, post-acute sequelae of COVID-19 (PASC) is a term that describes the long-term health problems that some people experience after being infected with the virus that causes COVID-19. These problems can last for weeks, months, or even years, and can affect various parts of the body, such as the heart, lungs, brain, and blood vessels. This narrative review paper utilized the PubMed database to explore the pathophysiology of post-COVID syndrome's neurological and psychiatric …

Masculine Ideals And Health In Older Men: Findings From The Wisconsin Longitudinal Study, Shane D. Burns, Patricia Drentea

APC Fund

How do older men’s masculine ideals affect their health? Are masculine activities involved in this relationship? Masculine identity upholds beliefs about masculine enactment. These beliefs can be detrimental to men and can lead to behaviors that can put undue stress on them. We examine how masculine ideals are associated with health and depressive symptomatology in older men. We used 2011 data from the Wisconsin Longitudinal Study (n = 2,594) to investigate how masculine ideals inform older men’s health and how participation in masculine activities might shape these outcomes. Findings from this study illustrate that traditional masculine ideals are associated …

Zirconia Implants: A Mapping Review, Steven J. Sadowsky

Pacific Faculty Work

The advent of zirconia ceramics with excellent mechanical, biomechanical, and optical properties has made them attractive metal-free substitutes for titanium implants. Both animal and human studies have documented shortcomings with titanium implants. A mapping review of the current literature on three iterations of zirconia implant designs has been challenging due to heterogeneous success data and limited follow-up. Zirconia implants hold promise for a new generation of dental implants, but technical developments are needed for design and material enhancements that will need to be validated by long-term rigorous studies.

Enhanced Bmp Signaling In Cathepsin K-Positive Tendon Progenitors Induces Heterotopic Ossification, Hiroyuki Yamaguchi, Margaret Li, Megumi Kitami, Sowmya Swaminathan, Yuji Mishina, Yoshihiro Komatsu

Faculty, Staff and Student Publications

Heterotopic ossification (HO) is abnormal bone growth in soft tissues that results from injury, trauma, and rare genetic disorders. Bone morphogenetic proteins (BMPs) are critical osteogenic regulators which are involved in HO. However, it remains unclear how BMP signaling interacts with other extracellular stimuli to form HO. To address this question, using the Cre-loxP recombination system in mice, we conditionally expressed the constitutively activated BMP type I receptor ALK2 with a Q207D mutation (Ca-ALK2) in Cathepsin K-Cre labeled tendon progenitors (hereafter “Ca-Alk2:Ctsk-Cre”). Ca-Alk2:Ctsk-Cre mice were viable but they formed spontaneous HO in the Achilles tendon. Histological and molecular …

The 2023 Orthopedic Research Society's International Consensus Meeting On Musculoskeletal Infection: Summary From The In Vitro Section, Noreen J. Hickok, Bingyun Li, Ebru Oral, Sebastian A.J. Zaat, David A. Armbruster, Gerald J. Atkins, Antonia F. Chen, Débora C. Coraça-Huber, Tianhong Dai, Edward M. Greenfield, Rajendra Kasinath, Matthew Libera, Cláudia N.H. Marques, T. Fintan Moriarty, K. Scott Phillips, Kapil Raghuraman, Dacheng Ren, Lia Rimondini, Kordo Saeed, Thomas P. Schaer, Edward M. Schwarz, Christopher Spiegel, Paul Stoodley, Vi Khanh Truong, Shao-Ting Jerry Tsang, Britt Wildemann, Anja R. Zelmer, Annelies S. Zinkernagel

Department of Orthopaedic Surgery Faculty Papers

Antimicrobial strategies for musculoskeletal infections are typically first developed with in vitro models. The In Vitro Section of the 2023 Orthopedic Research Society Musculoskeletal Infection international consensus meeting (ICM) probed our state of knowledge of in vitro systems with respect to bacteria and biofilm phenotype, standards, in vitro activity, and the ability to predict in vivo efficacy. A subset of ICM delegates performed systematic reviews on 15 questions and made recommendations and assessment of the level of evidence that were then voted on by 72 ICM delegates. Here, we report recommendations and rationale from the reviews and the results of …

Effect Of Triple Antibiotic Paste, Double Antibiotic Paste, And Calcium Hydroxide On Antibiotic Resistance Of Tet Repressor Proteins, Tetracycline Resistance Gene W, And Tetracycline Resistance Gene Q: A Randomized Controlled Clinical Trial, Ertuğrul Karataş, Özgen Kırmızıbekmez, Mustafa Özkan Baltacı, Ahmet Adıgüzel

Journal of Dentistry Indonesia

Objective: To investigate the effect of the use of Calcium Hydroxide (Ca(OH)2), Triple Antibiotic Paste (TAP), and Double Antibiotic Paste (DAP) as intra-canal medicaments on the development of antibiotic resistance by evaluating tetracycline genes. Methods: Forty five patients were randomly assigned into 3 groups according to the intracanal medication using a web program (www.randomizer.org), (Ca(OH)2, TAP and DAP). Root canal bacteriological samples were collected before root canal treatment (S1) and after chemo-mechanical procedures (S2). Following root canal shaping procedures, intra-canal medication of the root canals was performed with selected intra-canal medicament. A second appointment was planned for the …

The Effect Of Several Electric Cigarette Puffs On Nanohybrid Composite Resin Surface Roughness, Alvi Rizqi Amaliyah, Haris Budi Widodo, Irfan Dwiandhono

Journal of Dentistry Indonesia

Nanohybrid composite resin is a dental restorative material comprising micro and nano-sized fillers. When accompanied by smoking habits, it can alter the surface roughness of composite resin. Objective: This study aimed to determine the effect of several electric cigarette (e-cigarette) puffs on the surface roughness of nanohybrid composite resin. Methods: This study was conducted in the experimental laboratory with a pretest-posttest control group design using 48 nanohybrid composite resin specimens divided into six groups. Subsequently, the experimental groups were exposed to 75, 150, 225, 300, and 450 puffs of e-cigarette, and the control group was given artificial saliva …

Management Of Ankyloglossia In A Non-Syndromic Patient Using A Super Pulsed Laser: A Life-Changing Treatment- A Case Report, Urfi Jawed, Afaf Zia, Ramniwas Kumawat, Afshan Bey, Maahin Mahmood

Journal of Dentistry Indonesia

Objective: Ankyloglossia affects a person’s overall well-being and life, from malnutrition due to poor feeding and mechanical problems to psychological stress and low self-esteem, thus affecting social life. This case reports the use of non-scalpel techniques, such as a super pulsed laser, to manage ankyloglossia in a non-syndromic patient suffering from speech incompetence and restricted tongue mobility and highlights its advantages over other conventional techniques. Case Report: A 17-year-old male patient presented with a complaint of restricted tongue mobility, due to which he could not pronounce certain words clearly. As the patient was apprehensive about the use of …

Prevalence And Clinical Characteristics Of Temporomandibular Disorders In Adults: An Epidemiological Study In The Mediterranean Region Of Türkiye, Esra Yavuz, Selmi Yardimci, Humeyra Tercanli

Journal of Dentistry Indonesia

The prevalence and clinical characteristics of temporomandibular disorders (TMD) in the Mediterranean region of Türkiye have not yet been thoroughly investigated. Objective: This study aimed to determine the prevalence and severity of TMD in a sample of the population in this region and to characterize the clinical findings related to TMD. Methods: Four hundred and one participants were included in this study. “Presence of TMD” in the participants was evaluated using the Fonseca Anamnestic Index. Through clinical examination, the findings in the participants were classified as limited mouth opening, deviation, temporomandibular joint (TMJ) sounds, TMJ pain, and muscle …

Contents Vol 30 No 3 2023, Dr. Yuniardini Septorini Septorini Wimardhani

Journal of Dentistry Indonesia

This is the content of Vol. 30 number 3 2023.

Case Report And X-Ray Microtomography And Scanning Electron Microscopy Analysis Of Teeth With Hypocalcified Amelogenesis Imperfecta, Rodrigo W. Marinoni, Thiago G. Silva, Leonardo S. Benato, Anelize M B Rumbelsperger, Antonio Adilson Soares De Lima

Journal of Dentistry Indonesia

Amelogenesis imperfecta (AI) is a genetic disease characterized by producing morphological and structural changes in tooth enamel. Objective: To highlight the morphological changes observed in teeth with hypocalcified AI based on scanning electron microscopy and microtomography analysis. Case report: An adult male had teeth seriously compromised by hypocalcified AI. The treatment plan involved removal of third molars followed by restorative and prosthetic treatment. After extraction, the teeth were analyzed by SEM and X-ray microtomography (microCT). Teeth with AI revealed the presence of microfractures arranged from the outer surface to the center of the enamel. Microfractures had a cracked or “cracked …

Comparison And Assessment Of Design, Handling Characteristics, And Efficacy Of Hand Instruments In Calculus Removal, Mohan Kumar Pasupuleti, Krishna Ganesh, Gautami S Penmetsa, Boddeda Anusha, Haripriya Narukurthi, Kommina Mouna Sahith

Journal of Dentistry Indonesia

Objective: primary objective of periodontal therapy is to remove supra and subgingival deposits from the tooth surface to stop disease progression. The purpose of the study is to address the instrument selection and its efficacy in calculus removal. Methods: A total of 50 subjects who fulfilled the criteria were included in the study. Participants were subjected to a complete periodontal examination, and the responses from 50 dental house surgeons were compared based on the instrument design, handling characteristics, and efficacy of calculus removal by using two sets of instruments. Results: The LM instrument was rated as best …

Elastic Recovery Properties Of Alginate Impression Materials Based On Red Algae Kappaphycus Alvarezii, Didin Erma Indahyani, Izzata Barid, Nafisah Nafisah, Depi Praharani, Agus Sumono, Niken Probosari, Sulistiyani Sulistiyani

Journal of Dentistry Indonesia

Alginate impression materials in dentistry are used to form details of the oral cavity organs. The alginate content in the impression material functions to form a gel. One source of alginate is algae. Objective: This study aims to determine the recovery elasticity and setting time of alginate impression materials made from red algae K. alvarezii. Methods: The sodium alginate in the composition of this alginate impression material was extracted from red algae K. alvarezii. The alginate impression material was tested for setting time and recovery elasticity and compared with commercial impression material (Hygedent®). Results: The elastic …

Enigmatic Cervicofacial Actinomycosis Post Radiotherapy - A Case Report, Amanda Phoon Nguyen

Journal of Dentistry Indonesia

Although thought to be uncommon, it is believed that cervicofacial actinomycosis is underreported due to frequent misdiagnosis. It has been called the “most misdiagnosed disease by experienced clinicians”. A wide range of dental procedures or trauma, including tooth eruption, may precipitate actinomycosis by enabling microorganisms to penetrate the deeper tissue layers via an entry point. This infective disease is significant due to its potentially aggressive and locally destructive nature. This case describes a patient diagnosed with cervicofacial actinomycosis. Her history prior to this was significant for proliferative verrucous leukoplakia, and T4aN0M0 (AJCC 7th Edition) squamous cell carcinoma of the right …

Clinically Effective Regenerative Therapy For Primary Endodontic Lesions With Secondary Periodontal Lesions: A Case Report, Martina Amalia, Budi Budi, Iceu Estu Kurmaena, Nevi Yanti, Hesty Nurcahyanti, Aini Hariyani Nasution

Journal of Dentistry Indonesia

The diagnosis and prognosis of teeth with endo-perio lesions present a major challenge for dentists. Proper diagnosis is critical in determining treatment and the long-term prognosis. However, treating complex endodontic and periodontal lesions is one of the most common challenges in current clinical practice. The coexistence of pulpal and periodontal tissue damage may complicate diagnosis and further influence dental prognosis. This article consists of a case report evaluating the efficacy of xenografts and resorbable membrane pericardium in treating bifurcation lesions associated with periodontal lesions of the left mandibular first molar. A 22-year-old female patient was referred by conservative dentistry with …

Mechanisms Linking Proteins And Structural Brain Integrity To Biological Markers Of Alzheimer’S Disease, Adam Turnbull, Yejin Kim, Kai Zhang, Tianrui Mao, Xiaoqian Jiang, Victor Henderson, Zihuai He, Feng Vankee Vankee Lin

Faculty, Staff and Student Publications

Background

Medial temporal lobe (MTL) networks, including posterior-medial (PM) and anterior-temporal (AT) subnetworks, are early affected by Alzheimer’s disease (AD) pathologies (tau, neurodegeneration) and are critical for memory, which declines in AD. The biological pathways linking AD pathology, changes in MTL-AT-PM structural connectivity (SC), and cognitive decline, are unknown. Plasma protein levels reflect those in the cerebrospinal fluid, providing a low-invasive potential means of understanding molecular brain changes that occur in AD. These measures may help explain how AD pathology, MTL-AT-PM SC, and cognitive decline are linked at the molecular level. We used predefined aging-related plasma proteins from a meta-analysis …

The Effects Of Poly(Ethylene Glycol) Grafting Density On The Extensional Solution Flows Of High Molecular Weight Polyacrylamide, Adam Linscott, Lauren Hong, Svetlana Morozova

Faculty Scholarship

Controlling the extensional rheological properties of solutions is of great interest for a number of applications, such as printing and coatings, as polymeric additives can modify a fluid's droplet size, formation, and breakup. We have measured the extensional flows of polyacrylamide graft poly(ethylene glycol) amine (PAM-g-PEGa) solutions as a function of grafting density. PAM-g-PEGa is synthesized with grafting densities of 2.5%, 5.5%, 8%, and 30% and extensional flow was analyzed with drop-on-substrate rheology. Flow time scales and profiles are then compared to understand the effects of backbone extension from the addition of side chains. At low grafting densities, the viscous …

Information Literacy Skills Among Female Students Of Secondary Schools In Bangladesh, Wares-Ul-Matin, Md. Jahangir Alam, Bilkis Begum, Md. Sakib Biswas

Library Philosophy and Practice (e-journal)

This study assessed information literacy skills among female students of secondary schools in Bangladesh. A structured questionnaire was developed consisting of library and ICT facilities, information literacy skills, ability to locate information, evaluate information sources, and use the approach of needed information. A total of 596 data were collected from female students of class nine of five general and five girls' high schools in the rural areas of Dhaka Districts. The study revealed that overall, 60.23% of the respondents were aware of IL; however, 49.33% of the female students were unable to locate academic information, 69.63% failed to identify information …

Hormone Replacement Therapy Is Associated With Disease Activity Improvement Among Post-Menopausal Women With Inflammatory Bowel Disease, Morgan Freeman, Lauren Lally, Levi Teigen, Elliot Graziano, Raina Shivashankar, Eugenia Shmidt

Division of Gastroenterology and Hepatology Faculty Papers

(1) Background: There are limited data available to guide clinical decision-making regarding the effects of hormone replacement therapy (HRT) in post-menopausal women with inflammatory bowel disease (IBD). In this study, we sought to characterize a population of post-menopausal women with IBD and to determine the effects of HRT on their disease activity. (2) Methods: A multicenter, retrospective, case–control cohort study of post-menopausal women with IBD was conducted. The physician global assessment (PGA) score was used to quantify disease activity. To control for the effects of menopause, IBD patients who had not undergone HRT were used as controls. (3) Results: There …

Effects Of Mars Global Simulant (Mgs-1) On Growth And Physiology Of Sweet Potato: A Space Model Plant, Karthik Chinnannan, Prapooja Somagattu, Hyndavi Yammanuru, Padma Nimmakayala, Manohar Chakrabarti, Umesh K. Reddy

School of Integrative Biological & Chemical Sciences Faculty Publications

Growing food autonomously on Mars is challenging due to the Martian soil's low nutrient content and high salinity. Understanding how plants adapt and evaluating their nutritional attributes are pivotal for sustained Mars missions. This research delves into the regeneration, stress tolerance, and dietary metrics of sweet potato (Ipomoea batatas) across different Mars Global Simulant (MGS-1) concentrations (0, 25, 50, and 75%). In our greenhouse experiment, 75% MGS-1 concentration significantly inhibited sweet potato growth, storage root biomass, and chlorophyll content. This concentration also elevated the plant tissues' H2O2, proline, and ascorbic acid levels. Higher MGS-1 exposures (50 and 75%) …

Academic Clustering: A Longitudinal Analysis Of A Division I Football Program, Jeffrey J. Fountain, Peter S. Finley

Journal of Issues in Intercollegiate Athletics

As NCAA Division I coaches feel greater pressure to produce winning teams while ensuring that athletes remain eligible and progress toward degrees to avoid sanctions under the NCAA’s academic reform initiatives, concerns regarding the clustering of athletes into limited numbers of academic majors has increased. Academic clustering occurs when 25% or more of the members of one team share a single academic major (Case, Greer, & Brown, 1987). Recent studies have extended the analysis of clustering to include the disparate impact on white and minority football players in a single athletic conference (Fountain & Finley, 2009), as well as consideration …

Use Of Social Media In Public Archives: Perspectives About Ghana’S Readiness And Perceived Challenges., Reuben Saah, Samuel Abban, Esther White

Journal of Contemporary Archival Studies

The study explored the readiness and challenges of social media adoption at the Public Records and Archives Administration Department (PRAAD) in Ghana and was guided by the Iacovou, Charalambos L., Izak Benbasat, and Albert S. Dexter model of Electronic Data Interchange adoption. Using the qualitative approach, 13 participants drawn from the Archives Division were interviewed to explore their perspectives. The results showed that besides the participants high understanding and awareness of the benefits of social media adoption, clients were interested to engage PRAAD on social media. However, PRAAD’s readiness to adopt and effectively use social media was inadequate due to …

School Of Culinary Arts & Food Technology Newsletter - Winter Edition 2023, James Murphy

Other resources

The School of Culinary Arts and Food Technology, TU Dublin, Winter Newsletter captured the many events, sustainability, research, awards, significant contributions and special civic and community activities plus our school's committments to TU Dublin's SDGs which the students and staff members of the school across our (3) three campuses have successfully completed up to the Winter period of 2023. The successful completion of these activities would not be possible without the active and on-going support of the 'INSPIRED' friends of Culinary Arts (school supporters) and our school's industry association supporters.

Search For Osme Bonds With Π Systems As Electron Donors, Xin Wang, Qingzhong Li, Steve Scheiner

Chemistry and Biochemistry Faculty Publications

The Osme bond is defined as pairing a Group 8 metal atom as an electron acceptor in a noncovalent interaction with a nucleophile. DFT calculations with the ωB97XD functional consider MO₄ (M = Ru, Os) as the Lewis acid, paired with a series of π electron donors C₂H₂ , C₂H₄ , C₆H₆ , C₄H₅N, C₄H₄O, and C₄H₄S. The calculations establish interaction energies in the range between 9.5 and 26.4 kJ/mol. Os engages in stronger interactions than does Ru, …

Role-Reversibility, Ai, And Equitable Justice - Or: Why Mercy Cannot Be Automated, Stephen E. Henderson, Kiel Brennan-Marquez

JCLC Online

A few years ago, we developed the concept of “role-reversibility” in AI governance: the idea that it matters whether a party exercising judgment is reciprocally vulnerable to the effects of judgment. This idea, we argued, supplies a deontic reason to maintain certain spheres of human judgment even if (or when) truly intelligent machines become demonstrably superior in every utilitarian sense. While computer science remains far from that holy grail, generative AI is raging through systems as diverse as healthcare, finance, advertising, law, and academe, making it imperative to further shore up our claim. We do so by situating role-reversibility within …

Science Communication Through Cool Critters: An Informal Learning Experience For Youth, Jamila Bajelan

Communication Theses, Dissertations, and Student Creative Activity

There are numerous methods to communicate science, and one such method aims at increasing participants’ personal responses (awareness, enjoyment, interest, opinion, and understanding) of science. Informal science learning experiences, such as summer camps, are excellent settings to communicate science to young people. In addition, summer camps offer several opportunities to decrease the negative effects of the summer slide, a phenomenon that refers to the loss of students’ math and reading skills over the summer. For this study, I sought to build on this foundation and develop an informal learning experience for young people to communicate the science of native animals …

Improving And Integrating Quantitative Single Cell Spatial Biology For Theranostic Medicine, Peng Lu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Disease states are the result of a complex interplay of many different cell types interacting in close proximity in the context of often heterogeneous tissues. Alpha particles are drawing intense research and clinical interest because of their potent cytotoxic effects and their short path lengths. Analyzing the dose distribution and tissue micro-environment for alpha therapy plays a key role in predicting the efficacy of this targeted radiotherapy. However, to date there have been no direct on-tissue analytical methods for alpha dose distributions and the corresponding tissue microenvironments. Therefore, we have developed a pipeline to overcome this limitation by utilizing quantitative …

Divergent Self-Assembly Of Block Heterochiral Stereoisomer Arrays, Conor Louis O'Neill

McKelvey School of Engineering Graduate Student Theses & Dissertations

The autonomous organization of parts into ordered architectures, or biomolecular self-assembly, is an elementary natural process that defines and guides the construction and function of living organisms. This phenomenon has emerged as a potent tool for the creation of novel biomaterials, with peptide-based instances benefitting from intrinsic modularity, ease of de novo design and synthesis, biocompatibility, and chemical versatility. These properties enable methodical modifications that generate suprastructures with a wide variety of morphologies and functionalities, supporting a broad range of biomedical applications. Further, the chiral nature of amino acids permits synthesis of either left- or right-handed peptides; in recent years, …

Palmitate Induces Integrated Stress Response And Lipoapoptosis In Trophoblasts, Prakash Kumar Sahoo, Chandan Krishnamoorthy, Jennifer R. Wood, Corrine Hanson, Ann Anderson-Berry, Justin L. Mott, Sathish Kumar Natarajan

Department of Animal Science: Faculty Publications

Maternal obesity increases the risk of childhood obesity and programs the offspring to develop metabolic syndrome later in their life. Palmitate is the predominant saturated free fatty acid (FFA) that is transported across the placenta to the fetus. We have recently shown that saturated FFA in the maternal circulation as a result of increased adipose tissue lipolysis in third trimester of pregnancy induces trophoblast lipoapoptosis. Here, we hypothesized that palmitate induces integrated stress response by activating mitogen-activated protein kinases (MAPKs), endoplasmic reticulum (ER) stress and granular stress and lipoapoptosis in trophoblasts. Choriocarcinoma-derived third-trimester placental trophoblast-like cells (JEG-3 and JAR) referred …

The Effect Of Hedgerow Age On Vegetative Species Diversity, Matthew Blogg

The Plymouth Student Scientist

Hedgerows are a distinctive part of the English countryside and provide many ecological benefits and services. Over recent history, hedgerows have been removed and replanted, resulting in a matrix of different aged hedgerows across the country. In this study, the effect of hedgerow age on vegetative species diversity was tested to see if older hedgerows contained a higher species diversity than younger hedgerows. Four hedgerows of varying ages were tested on an urban farm in Plymouth, Southwest England. Percentage cover of each species was measured across ten samples in each hedgerow, with a Shannon’s diversity score being calculated for each …