Digital Commons Network^™

Phase Separation In Biology And Disease; Current Perspectives And Open Questions, Steven Boeynaems, Shasha Chong, Jörg Gsponer, Liam Holt, Dragomir Milovanovic, Diana M. Mitrea, Oliver Mueller-Cajar, Bede Portz, John F. Reilly, Christopher D. Reinkemeier, Benjamin R. Sabari, Serena Sanulli, James Shorter, Emily M. Sontag, Lucia Strader, Jeanne Stachowiak, Stephanie C. Weber, Michael R. White, Huaiying Zhang, Markus Zweckstetter, Shana Elbaum-Garfinkle, Richard Kriwacki

Biological Sciences Faculty Research and Publications

In the past almost 15 years, we witnessed the birth of a new scientific field focused on the existence, formation, biological functions, and disease associations of membraneless bodies in cells, now referred to as biomolecular condensates. Pioneering studies from several laboratories supported a model wherein biomolecular condensates associated with diverse biological processes form through the process of phase separation. These and other findings that followed have revolutionized our understanding of how biomolecules are organized in space and time within cells to perform myriad biological functions, including cell fate determination, signal transduction, endocytosis, regulation of gene expression and protein translation, and …

The Allele Catalog Tool: A Web-Based Interactive Tool For Allele Discovery And Analysis, Yen On Chan, Nicholas Dietz, Shuai Zeng, Juexin Wang, Sherry Flint-Garcia, M. Nancy Salazar-Vidal, Mária Škrabišová, Kristin Bilyeu, Trupti Joshi

Biomedical Sciences

Background: The advancement of sequencing technologies today has made a plethora of whole-genome re-sequenced (WGRS) data publicly available. However, research utilizing the WGRS data without further configuration is nearly impossible. To solve this problem, our research group has developed an interactive Allele Catalog Tool to enable researchers to explore the coding region allelic variation present in over 1,000 re-sequenced accessions each for soybean, Arabidopsis, and maize.

Results: The Allele Catalog Tool was designed originally with soybean genomic data and resources. The Allele Catalog datasets were generated using our variant calling pipeline (SnakyVC) and the Allele Catalog pipeline (AlleleCatalog). The …

A Trial Of Fire And Ice: Assessment Of Control Techniques For Pyrus Calleryana Invasion Of Grasslands In Southwestern Ohio, Usa, Margaret E. Maloney, Eric B. Borth, Grace Dietsch, Mary C. Lloyd, Ryan W. Mcewan

Biology Faculty Publications

Pyrus calleryana (Callery pear) is an invasive plant that threatens ecosystems in the eastern United States. We investigated the efficacy of various control techniques on P. calleryana invasion in grasslands. Treatments were applied to (a) P. calleryana stems that had experienced mowing annually for several years and were sprouting (n = 100 stems; “trees-sprouting”) and (b) stems that had established ca. 10 years earlier, had never been cut, and were single-stemmed trees (n = 40 stems; “trees-intact”). In both experiments, existing stems were cut and randomly assigned one of the following treatments: cut only (control), burning, freezing, or herbicide, and …

Validation Of The Entrainment Signal Regularity Index And Associations With Children’S Changes In Bmi, Jennette P Moreno, Kevin M Hannay, Amy R Goetz, Olivia Walch, Philip Cheng

Children’s Nutrition Research Center Staff Publications

Objective: This study examined the validity of a novel metric of circadian health, the Entrainment Signal Regularity Index (ESRI), and its relationship to changes in BMI during the school year and summer.

Methods: In a longitudinal observational data set, this study examined the relationship between ESRI score and children's (n = 119, 5- to 8-year-olds) sleep and physical activity levels during the school year and summer, differences in ESRI score during the school year and summer, and the association of ESRI score during the school year and summer with changes in BMI across those time periods.

Results: The ESRI score …

Strengthening The Institution Of Marriage As The Union Of One Man And One Woman, Seow Hon Tan

Research Collection Yong Pung How School Of Law

This article examines the recent repeal of section 377A of the Penal Code and the concurrent constitutional amendment to strengthen the institution of marriage as the union of one man and one woman. Specifically, it explains the jurisprudential significance of the new constitutional provision, Article 156, which has a bearing on our understanding of the laws and policies to be enacted and implemented in future.

Let Them Play: The Case For Allowing Minors To Play Professional Sports, Zachary Bawduniak

Hofstra Labor & Employment Law Journal

No abstract provided.

Aged 539 Graduate Internship Report - Pacheco High School, Spencer C. Bronken

Agricultural Education: Graduate Internship Reports

This internship and project report includes validation documents required in meeting the quality criteria for secondary-level programs of instruction in agriculture. The supporting material includes information to receive state and local funding, outline the goals and objectives of the program, along with an overview of Pacheco High School, the agriculture program, and the community.

Developing And Implementing A Sustainable, Integrated Weed Management Program For Herbicide-Resistant Poa Annua In Turfgrass, James D. Mccurdy, Rebecca G. Bowling, Edicarlos De Castro, Alec R. Kowalewski, Clint M. Maddox, James T. Brosnan, Shawn W. Askew, Clebson G. Goncalves, David Ervin, Multiple Additional Authors

Economics Faculty Publications and Presentations

The ability of Poa annua L. to adapt to most turfgrass environments extends to its ability to develop resistance to commonly used herbicides. Herbicide resistant P. annua is of almost epidemic proportions. The loss of once viable chemical-based treatments pushes practitioners towards more expensive, and often less effective, control strategies. This management guide focuses on integrated weed management (IWM) practices for P. annua control and herbicide resistance—what it is and how to overcome it. Also discussed are resistance mechanisms and documentation of common occurrences of field-level resistance within much of the United States. Finally, a summary of some of the …

Classifying Severe And Enduring Anorexia Nervosa: A Literature Review, Phoenix Black

University Honors Theses

Little focus is placed on the subsection of the eating disorder patient population who struggle chronically with their illness. This review synthesizes research on the topic to identify gaps in knowledge and reflect on implications for diagnosis and classification of severe and enduring anorexia nervosa. There was some variability between both clinicians and researchers who focused on this patient population, which is discussed based on different classifying criteria used to include or exclude an individual into the study. This review considers traditional methods used for classifying psychiatric diagnoses in relation to this disorder.

Emotion Socialization In The Indian Cultural Context, Tripti Kathuria, Shagufa Kapadia Prof., Wolfgang Friedlmeier

Online Readings in Psychology and Culture

The social cultural norms that guide parental practices regarding emotion socialization are determined by cultural meanings ascribed to emotion, emotion expression, regulation, and larger socialization goals. The majority of the empirical research on emotion socialization has been carried out in the US and in Western European countries. The current article aims at understanding emotion socialization in the Indian context interweaving broader views on parenting and socialization, socialization goals, and ancient and modern emotion concepts that shape emotion socialization in India. The heterogeneity of the Indian culture as well as modernization processes that influence these practices suggest heterogeneity of emotion socialization …

Hypoxic Incubator Control System, Marina Zellers, Jennifer Rojas, Derek Tran

Biomedical Engineering

This paper describes the functionality of the current Hypoxic Incubator, a project started by BMED graduate students Simone Helfrich and Makenzie Jones, with the objective being to redesign the device to address potential areas of improvement. The hypoxic incubator has been designed to allow for the control of the O₂, CO₂, and N₂ levels such that researchers can grow and study cell culture in hypoxic conditions; however, its efficacy and efficiency are limited by the fact that it often overshoots the desired setpoints for O₂ and CO₂ in addition to being difficult to …

Gait Analysis Device For Elderly Fall Prediction, Ryan Hahn, Claudia Miller, Evan Yakligian

Biomedical Engineering

This document serves to outline the design process and final design for our project to address elderly independent living in collaboration with Apple. Included in this document is necessary academic literature of current fall risk assessments and descriptions of the current market of wearable gait analysis devices. Based on this research and data, we then outline a plan for design, manufacturing, prototyping, and testing a device to fulfill the original prompt given by our sponsors: create a device that will increase the ability of an aging loved one to live at home safely. This device is a wearable that collects …

Metabolic Network Modeling To Unravel The Impact Of Copper Deficiency And High-Fat Diet On Liver Metabolism, Naeun Lee

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Fatty liver disease is a common health problem caused by an imbalance in the intake, utilization, and distribution of energy. High-fat and high-carbohydrate diets have been identified as major risk factors for fatty liver disease. Other contributors and modifiers can also influence the development of liver damage. Intriguingly, inappropriate copper (Cu) levels in the diet and organs are associated with fatty liver disease, though the exact way in which Cu deficiency or toxicity contributes to metabolic issues is not yet clear. Cu is necessary for several biological processes, including energy production and redox balance. Further research should be taken to …

Recent Advances In Centrifugal Spinning And Their Applications In Tissue Engineering, Shaik Merkatur Hakim Marjuban, Musfira Rahman, Syeda Sharmin Duza, Mohammad Boshir Ahmed, Dinesh K. Patel, Md Saifur Rahman, Karen Lozano

Mechanical Engineering Faculty Publications

Over the last decade, researchers have investigated the potential of nano and microfiber scaffolds to promote wound healing, tissue regeneration, and skin protection. The centrifugal spinning technique is favored over others due to its relatively straightforward mechanism for producing large quantities of fiber. Many polymeric materials have yet to be investigated in search of those with multifunctional properties that would make them attractive in tissue applications. This literature presents the fundamental process of fiber generation, and the effects of fabrication parameters (machine, solution) on the morphologies such as fiber diameter, distribution, alignment, porous features, and mechanical properties. Additionally, a brief …

The Parthenon, March 1, 2013, Evan Green, Conner Woodruff, Matt Schaffer, Chayce Matheny, Victoria Ware, Shauntelle Thompson, Rafael Alfonso, Scott Price

The Parthenon

No abstract provided.

Susceptibility Of Pre-Adult Biological Stages Of Mythimna Separata (Walker) (Lepidoptera: Noctuidae) To Three Entomopathogenic Fungi (Hypocreales), Melissa P. Montecalvo, Marcela M. Navasero

The Philippine Agricultural Scientist

Armyworms are polyphagous insect pests of agricultural crops. Their population is usually managed below threshold level using insecticides. However, a single control measure is insufficient to attain a sustainable pest management. Hence, this research was conducted to assess the three species of entomopathogenic fungi as potential biological control agents against Mythimna separata (Walker) or paddy armyworm. Dose mortality assays were conducted to determine the pathogenicity of Beauveria bassiana (Bals.) Vuill., Metarhizium anisopliae (Metschn.) Sorokin, and Metarhizium rileyi (Farlow) Kepler, S.A. Rehner and Humber against various biological stages of M. separata including egg, 1^st to 6^th larval instars, prepupa, …

Grow-Out Culture Of Oyster Magallana Bilineata (Röding, 1798) Using Pouches: A Comparison Of Growth And Survival In The River And Earthen Pond, Ma. Junemie Hazel L. Lebata-Ramos, Ellen Flor D. Solis, Mark Jude C. Almeida

The Philippine Agricultural Scientist

Oysters are among the most in-demand aquaculture commodities in the Philippines and worldwide. With the decreasing culture area and the deteriorating water quality of oyster beds, there is a need to explore new culture sites and techniques to address the problems of dwindling stocks and the increasing demand for better quality oysters. This study compared the growth and survival of the oysters Magallana bilineata, the new accepted name of Crassostrea iredalei, cultured in an earthen pond and the river using pouches suspended from rafts. Mean growth rates of oysters in length and weight were significantly higher in those …

Exploring 3d Structured Illumination Microscopy Images Using The Image J Software, David Adaway, Bilha Magu, Brandon Walton, Bereket Kebede

QuaesitUM

No abstract provided.

Design & Evaluation Of A Confocal Scanning Microscope Using Off-Of-Shelf Optical Components By Means Of Zemax Opticstudio Optical Design Software, Ethan Costello

QuaesitUM

No abstract provided.

Synthesis Of Transition Metal Sulfides Via Low-Pressure Chemical Vapor Deposition, N.K. Lam

QuaesitUM

No abstract provided.

Mapping The Amplitude And Frequency Of Pressure Drop Oscillations Via A Transient Numerical Model To Assess Their Severity During Microchannel Flow Boiling, Md Emadur Rahman, Justin Weibel

CTRC Research Publications

No abstract provided.

Machine-Learning-Aided Design Optimization Of Internal Flow Channel Cross-Sections, Saeel S. Pai, Justin Weibel

CTRC Research Publications

No abstract provided.

Six Decades Of North American Bird Banding Records Reveal Plasticity In Migration Phenology, Kyle G. Horton, Sara R. Morris, Benjamin M. Van Doren, Kristen M. Covino

Biology Faculty Works

1. The timing of avian migration has evolved to exploit critical seasonal resources, yet plasticity within phenological responses may allow adjustments to interannual resource phenology. The diversity of migratory species and changes in underlying resources in response to climate change make it challenging to generalize these relationships.
2. We use bird banding records during spring and fall migration from across North America to examine macroscale phenological responses to interannual fluctuations in temperature and long-term annual trends in phenology.
3. In total, we examine 19 species of North American wood warblers (family Parulidae), summarizing migration timing from 2,826,588 banded birds from 1961 to 2018 …

Climate And Pest Interactions Pose A Cross-Landscape Management Challenge To Soil And Water Conservation, Joshua W. Campbell, Michael R. Fulcher, Brenda J. Grewell, Stephen L. Young

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Climate change and biological invasions by plant pests (weeds), agriculture and forest insect pests (insects), and microbial pests (plant pathogens) are complex interactive components of global environmental change. The influence of pest distribution and prevalence across landscapes are challenging the conservation and sustainability of natural resources, agricultural production, native biological diversity, and the valuable ecosystem services they provide (Huenneke 1997; Vitousek 1997; Juroszek and von Tiedemann 2013; Ziska and Dukes 2014). Since 2000, numerous scientific studies indicate accelerating climate change is posing substantial risks to natural and managed systems in North America (IPPC 2022). Intensified droughts, largescale wildfires, and increased …

Modeling Vehicle-Miles Of Travel Accounting For Latent Heterogeneity, Fatemeh Nazari, Abolfazl (Kouros) Mohammadian

Civil Engineering Faculty Publications

Vehicle use is associated with negative externalities such as traffic congestion, air pollution, and greenhouse gas emissions. Particularly in the U.S. as a car-oriented country, vehicle use — in terms of vehicle-miles of travel (VMT) — has been on the rise and is projected to increase in the future. To curb the VMT growth and mitigate the associated externalities, policy makers can design informed strategies based on VMT predicted by vehicle use models. However, traditional vehicle use models capture merely the observed heterogeneity across vehicle decision making units (e.g., individuals) and ignore the latent or taste heterogeneity sourced in …

Evaluating The Relationship Between Circadian Rhythms And Sleep, Metabolic And Cardiovascular Disorders: Current Clinical Evidence In Human Studies, Maria Mentzelou, Sousana K. Papadopoulou, Dimitrios Papandreou, Maria Spanoudaki, Antonios Dakanalis, Georgios K. Vasios, Gavriela Voulgaridou, Eleni Pavlidou, Maria Mantzorou, Constantinos Giaginis

All Works

Circadian rhythms are generated by the circadian clock, a self-sustained internal timing system that exhibits 24-h rhythms in the body. Many metabolic, cellular, behavioral and physiological processes are regulated by the circadian clock in coordination with environmental cues. The present study is a comprehensive review of the currently existing evidence concerning the relationship between circadian rhythms and sleep, metabolic, and cardiovascular disorders. We thoroughly searched the online databases PubMed, Scopus, and Web of Science to find the existing clinical studies from the last twenty-three years (2000–2023). Circadian misalignment was found to be associated with an increase in the risk of …

Policy Comparison Of Lead Hunting Ammunition Bans And Voluntary Nonlead Programs For California Condors, Robin M. Rotman, John H. Schulz, Samantha Totoni, Sonja A. Wilhelm Stanis, Christine Jie Li, Mark Morgan, Damon M. Hall, Elisabeth B. Webb

Faculty Publications

The endangered California condor (Gymnogyps californianus) is negatively affected by lead poisoning from spent lead‐based hunting ammunition. Because lead poisoning is the primary mortality factor affecting condors, the California Fish and Game Commission banned lead hunting ammunition during 2008 in the southern California condor range followed by a statewide ban implemented in 2019. In contrast, the Arizona Game and Fish Department instituted an outreach and awareness program encouraging voluntary use of nonlead hunting ammunition in the northern portion of the state during 2005 and a similar program was launched in Utah during 2012. The juxtaposition of policy tools provided a …

Abstract 1858: Active And Allosteric Site Evolution Directs Ordered Water Use In Kinesin Catalysis, Micquel Downs, David Worthylake, Jessica Richard, Courtney Parke, Elizabeth Kim, Edward J. Wojcik, Sunyoung Kim

School of Graduate Studies Faculty Publications

2023 American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting; March 25 - 28, 2023; Seattle, WA

New Egfr Equations: Implications For Cardiologists And Racial Inequities, Nali Gillespie, Rajesh Mohandas

School of Medicine Faculty Publications

Recently, a new equation to predict estimated glomerular filtration rate (eGFR) that does not include a variable for race has been endorsed by professional organizations and increasingly adopted by clinical laboratories. We discuss the reasoning behind the development of the new equation, implications for cardiologists, and how the new eGFR equation could impact disparities in the cardiovascular care of these patients. Race, a social construct, is a poor proxy for biological variability. Clinical trials which recruit underrepresented minorities and advances in genomic medicine could accelerate the development of personalized medicine and help decrease inequalities in clinical outcomes.

The Anchor: March 2023, Hope College

The Anchor: 2023

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.