Digital Commons Network^™

Deep Learning For Microbiome-Based Integrative Modeling And Microbial Biomarkers Identification, Sen Yang

Statistical Science Theses and Dissertations

The human microbiome, comprising trillions of microorganisms, plays a pivotal role in modulating host physiology via molecular and metabolite exchanges. One of the major challenges in this field lies in the effective integration of microbiome and metabolomics data, an achievement that holds the promise of substantially enhancing the precision of disease prediction. However, many datasets prioritize microbiome data while neglecting paired metabolome information. Additionally, the prevalent analytical tools face challenges in effectively merging these intricate datasets, leading to possible misinterpretations and reduced prediction accuracies.

To address these challenges, the first part of this research introduces the Microbiome-based Supervised Contrastive Learning …

2023 Fall Commencement, Harding University

Commencement Programs

Program for the Harding University Commencement on December 16.

Commencement Speaker: Keith Cronk

Can A Healthy High Fat Diet Improve Fatigue Symptoms In Patients With Relapse And Remitting Multiple Sclerosis?, Sarah Von Euler, Elizabeth Henry

Physician Assistant Capstones, 2020-current

No abstract provided.

Portrayals Of Gender And Race In Instagram Advertising: An Exploratory Content Analysis, Taylor Moore

Honors College Theses

Race and gender stereotyping is a longstanding problem in the world of advertising. This research utilized content and statistical analysis to answer three questions regarding race and gender stereotyping in Instagram advertising: (1) what portrayals are being shown? (2) how are these portrayals being shown? And (3) are diverse advertisements reinforcing or challenging stereotypes? Tweny advertisements were chosen off Instagram to analyze. Through an analysis of literature on the topic, a code book defining race, person of color, sex, gender, and gender expression was created. Using these variables and classifying the ads as a stereotype/counterstereotype/neutral, allowed for the creation of …

Machine Learning For Automated Cervical Vertebral Maturation Assessment On Lateral Cephalograms, Nuo Dong

Theses & Dissertations

Introduction: Skeletal maturation age is an important guide in growing adolescent patients to determine the proper time to start orthodontic treatment. The most practical and commonly used method to determine skeletal age in today’s clinical practice is the Cervical Vertebral Maturation (CVM) method [2]. Based on the morphology of the cervical vertebrae, six maturational stages can be determined – designated CS 1 to CS 6. The main drawback of this technique is the time required to determine CS number. Objective: In this research a machine learning (ML) algorithm to automatically determine CVM staging from the lateral cephalometric radiograph was developed. …

Telling Stories: Teaching Children With Down Syndrome Story Grammar Using Augmentative And Alternative Communication, Seana Evelyn

Special Education ETDs

The prevalence of Down syndrome (DS) has increased over the past three decades, becoming one of the leading causes of intellectual disability (CDC, 2021; Chapman, 2003). Several studies have found that children with DS have difficulty with expressive syntax (Chapman, 2003; Fidler, 2005; Grieco et al., 2015), which impacts essential activities such as storytelling. However, no study was found that looked at the effectiveness of Augmentative and Alternative Communication (AAC) in improving narrative skills in children with DS. This study assesses the impact of explicit story grammar teaching using the Story Grammar Marker (SGM) and an AAC approach on three …

Colloid Fabrication For Biomedical Engineering Applications Through Droplet Microfluidics, Lewis I. Larsen

Biomedical Engineering ETDs

The goal of this work was to leverage soft colloid fabrication through droplet microfluidics to improve the biomedical fields of radiotracer microspheres for selective internal radiation therapy (SIRT) and 3D hydrogel tissue constructs for cell culture with future potential as a platform to study liver diseases and drug response. The importance of positron emission tomography (PET) imaging microspheres infused with positron-emitting radioisotopes such as Ga-68, Cu-64, and F-18 is that they accurately map tumor-to-liver uptake (TLR) ratio and lung shunting factor of hepatocellular carcinoma. These pretreatment radiotracers model the intravascular accumulation behavior of radioactive therapeutic Y-90 SIRT microspheres. Qualifying patients, …

757transfamily: Empowering Parents To Raise Their Transgender Child Through Knowledge, Connection, And Joy, Jessica Gurley

Institute for the Humanities Master's Papers, Projects, and Capstones

Parents of transgender and non-binary children often want to support their children, but are not sure how. Giving these parents the support and resources they need will increase their ability to support their children, further increasing the chance that their children will live a long, healthy, authentic life.

I built a website, and organized a workshop that parents can attend in order to access information and resources about the transgender community. These parents will receive the support they need to be better equipped to support their gender-diverse children. I will be collecting information about the parents' feelings and experience towards …

Characterizing The Ecology Of Plains (Spilogale Interrupta) And Eastern (Spilogale Putorius) Spotted Skunks: A Systematic Literature Review And Population Assessment In Kansas, Jenell De La Peña

Electronic Theses & Dissertations

The plains spotted skunk (Spilogale interrupta) has recently been recognized as a distinct species from the eastern spotted skunk (Spilogale putorius). While once abundant across the central and eastern United States, both species have experienced population declines, resulting in their review for listing under the Endangered Species Act (1973). In Kansas, the plains spotted skunk has suffered a particularly dramatic decline, the last detection in the state having occurred in 2020. Additionally, due to the recent taxonomic split, many past studies reporting on S. putorius ecology actually describe findings of two species, potentially complicating our understanding …

Computational Study Of The Effect Of Geometry On Molecular Interactions, Sarika Kumar

Computer Science ETDs

The specificity and predictability of DNA make it an excellent programmable material and have allowed bio-programmers to build sophisticated molecular circuits. These molecular devices should be precise, correct, and function as intended. In order to implement these circuits, the challenge is to build a robust, reliable, and scalable logic circuit with ideally minimum unwanted signal release. Performing experiments are expensive and time-consuming, so modeling and analyzing these bio-molecular systems become crucial in designing molecular circuits. This dissertation aimed to develop algorithms and build computational tools for automated analysis of molecular circuits that incorporate the molecular geometry of nanostructures. Molecular circuits …

Adult Presentation Of Congenital Tracheooesophageal Fistula Treated As Asthma And Recurrent Respiratory Infections, Natalie A Drucker, Charles S Cox

The Brown Foundation: Institute of Molecular Medicine

No abstract provided.

Neurobehavioral And Eeg Characteristics In Latino Targets Of Bullying, Isabel Solis

Psychology ETDs

Bullying adversely impacts the well-being and development of youth, calling for a comprehensive understanding of its neurobehavioral and social mechanisms for targeted interventions. Despite the increasing demographic of Latino children, little is known about their early life experiences and individual traits that leave them susceptible to becoming targets of bullying. The present study utilized a mixed-methods design to address this gap, incorporating interviews, neuropsychological assessments, and resting-state EEG (rsEEG) spectral power within the alpha (8-13Hz) and theta (4-7Hz) frequency bands. The aim was to compare the cognitive, emotional, social, and neural characteristics of nine Latino Targets (LT) of bullying and …

Volumetric Imaging Using The Pupil-Matched Remote Focusing Technique In Light-Sheet Microscopy, Sayed Hassan Dibaji Foroushani

Optical Science and Engineering ETDs

ABSTRACT

The dissertation explores innovative techniques in light sheet microscopy, a pivotal tool in biomedical imaging, to enhance its speed, resolution, and efficiency in capturing dynamic biological processes. Light sheet microscopy allows for quick 3D imaging of biological specimens ranging from cells to organs with high spatiotemporal resolution, large field-of-view, and minimal damage, making it vital for in vivo imaging.

The first project introduces a novel optical concept designed to optimize Axially Swept Light Sheet Microscopy (ASLM). This technique is crucial for imaging specimens ranging from live cells to chemically cleared organs due to its versatility across different immersion media. …

Heat & Social Cooperation: The Effects Of Thermal Stress On Altruism, Alexander J. Courtman

Master's Theses

Recent literature has highlighted the effects of temperature on economic outcomes and violence in humans, on both the interpersonal and intergroup levels: as temperatures rise, humans are more likely to exhibit increased aggression and agitation. However, little research has been done on how pro-social behaviors like cooperation and altruism among humans might respond to increased temperatures. As extreme heat events increase in frequency, will humans and communities work together in the face of adverse shocks and crises? Leveraging experimental data collected randomized controlled trails held in 4 locations across the world, this paper seeks to establish a relationship between thermal …

Correlation Analysis Between Agronomic Character And Yield Of Padjadjaran Maize Hybrids At Medium And High Population Densities, Yuyun Yuwariah, Qinthara Nail Haysa, Damara Bakti Muhammad, Dedi Ruswandi, Fiky Yulianto Wicaksono

Jurnal Kultivasi

Maize is a prospective food commodity that developed in Indonesia. The use of hybrid corn gives better yield than open-pollinated varieties. Spacing management in hybrid maize production can reduce competition between plants, so that the plant canopy and roots can grow optimally. This research aimed to compare the differences in the phenotypic performance of the agronomic characters of Padjadjaran maize hybrid, determine the dominant agronomic characteristics, and determine the correlation between the growth and yield characteristics at medium- and high-population densities. The experiment was carried out from December 2021 until May 2022 at Sanggar Penelitian, Latihan dan Pengembangan Pertanian (SPLPP) …

The Effectiveness Of Garlic Extract Against Spodoptera Litura On Chili, Efrin Firmansyah, Cecep Hidayat, Anna Aina Roosda, Adinda Nurul Fatah Adi Pradana, R Soelistijono

Jurnal Kultivasi

Spodoptera litura is a polyphagous pest and attack many families of cultivated plants, such as chili plants. Application of synthetic pesticides is still the mainstay for controlling this pest in the field. To support eco-friendly plant protection management, it is important to explore potential natural materials such as garlic extract. This research aims to determine the potential of garlic extract in controlling S. litura on chili plants, and to see its indirect effect on chili yield. The research was carried out in two sites, in the laboratory and the field. The experiment used a completely randomized design with 6 treatments …

Callus Induction And Proliferation Of Centella Asiatica L. Generated From Leaves And Petioles In The Presence Of Dicamba And Bap, Suci Rahayu, Darmawan Saptadi, Chotimatul Azmi, Kusumawaty Kusumanegara, Tri Handayani, Ika Roostika, Nurliani Bermawie, Haris Maulana

Jurnal Kultivasi

Centella's need for industrial raw materials is high as a medicinal plant. These needs can be met through rapid multiplication using tissue culture techniques. In this study, induction and proliferation for a callus of centella cv. Castina 3 was conducted in the MS basal medium plus 4 mgL-1 Dicamba withand enriched with 7 concentrations of BAP (0, 0.1, 0.3, 0.5, 0.7, 0.9, and 1.1 mgL-1). Two kinds of explant were used, i.e., leaf and petiole. The results revealed that the addition of BAP in MS plus Dicamba medim stimulated better and produced a higher callus growth rate, both from leaf …

A Preliminary Study On Floating Flexible Otec Cold Water Pipe, Nai Kuang Liang, Hai Kuan Peng

Journal of Marine Science and Technology–Taiwan

Ocean Thermal Energy Conversion (OTEC) requires a large amount of cold seawater. The traditional rigid pipe, semi-rigidly fixed onto the ship bottom is not easy to install and disassemble, so the Floating Flexible Cold Water Pipe (FFCWP) flexibly connected to the ship is proposed. A small FFCWP was designed, fabricated, and successfully installed and recovered in the sea. The flexible pipe adopts commercially available fire ventilation snake pipe. The pipe wall material strength must be improved in the future. Assuming that the drag coefficient Cd value is 1.5, a numerical calculation is employed to simulate the FFCWP attitude from the …

Machine Learning With Multi-Source Data To Predict And Explain Marine Pilot Occupational Accidents, Gokhan Camliyurt, Youngsoo Park, Daewon Kim, Won Sik Kang, Sangwon Park

Journal of Marine Science and Technology–Taiwan

Marine pilot occupational accidents during transfer to/from ships are the primary concern of the International Marine Pilots’ Association (IMPA) and industry professionals. There are multiple transfer methods for marine pilots, with the most common being the pilot boat. To reach the mother ship bridge, the following stages must be safely completed: car transfer, walking on the pier, pier to pilot boat, pilot transfer by boat, cutter to pilot ladder, mother ship freeboard climbing, and ship deck to the bridge. Each stage has its own risk. Previous accident records and expert opinions are commonly used to conduct a risk analysis and …

Evaluation Of Operational Performance Of Wusongkou Cruise Port Through Network Data Envelopment Analysis, Qian-Feng Wang, Guo-Ya Gan, Xin-Liang Ye, Hsuan-Shih Lee

Journal of Marine Science and Technology–Taiwan

As major hubs for cruise berthing and passenger transfers, cruise ports in China were developing rapidly in the years before the COVID-19 pandemic because of an ever-growing regional market. Wusongkou Cruise Port is the most important port for cruise ships in China, and this study evaluated the operational performance of this port during 2011–2020. To this end, two-stage network data envelopment analysis was conducted to evaluate the port’s operation performance; subsequently, the change trajectory of the port’s operational efficiency during 2011–2020 was determined, and the potential reasons for the identified changes are discussed. Finally, suggestions for improving the operational performance …

Is Digital Altruism The Same As Offline Altruism?: An Exploration Of Strength-Based Determinants Among Generation Z During Covid-19 Pandemic, Nair Shravya Sunil, Surekha Chukkali

Internet Journal of Allied Health Sciences and Practice

Digital altruism is a new form of altruism on social media platforms. Social media has been a vital tool for sharing and seeking information for day-to-day situations, enabling people to seek and render help. Engaging in helping behaviour could be purely out of altruism or can be traced back to their professional requirements. Social media platforms have brought out people’s altruistic side on multiple occasions. The present study looked at the altruism levels of Indian Generation-Z social media users and how it is influenced by the users’ strength-based determinants, i.e. empathy, compassion, social justice, optimism, social intelligence, and personality, compared …

Working Hours, Sleep, And Burnout Among Athletic Trainers Employed In College Athletics: A Cross-Sectional Study, Stephanie M. Singe, Catherine G. Mydosh, Alexandrya Cairns, Christianne M. Eason

Internet Journal of Allied Health Sciences and Practice

Purpose: Burnout continues to be an important concern for athletic trainers working in the collegiate sport setting. The purpose of the study was to examine the relationships between working hours, sleep, and burnout among athletic trainers providing patient care in the collegiate setting. Methods: A web-based (Qualtrics, Provo, UT) cross-sectional study using a self-reported questionnaire was used to collect demographics and data on working hours, sleep, and burnout. The Copenhagen Burnout Inventory (CBI) was used to determine burnout. Results: The mean age of our participants (n=1006) was 33 ∓ 9 years; 37.6% (n=378) were male, 61.5% (619), and 1.1% …

An Integrated Strategy To Evaluate Active Substances Of Astragali Radix-Carthami Flos Combination On The Treatment Of Cerebral Ischemia Reperfusion Injury Based On Tqsm Polypharmacokinetics And Pharmacodynamics, Qiang Zeng, Chang Li, Shouchao Xu, Yu He

Journal of Food and Drug Analysis

As a classic herb pair, Astragali Radix-Carthami Flos (AR-CF) has revealed good biological activity in the treatment of cerebral ischemia/reperfusion injury (CI/RI), which remained to be further clarified together with the underlying efficacy related compounds for material basis. In this study, the nine formulations were obtained by L₉(3⁴) orthogonal array design of four active fractions (saponin and flavonoid extracted from AR, safflower yellow and safflower red extracted from CF). The concentrations of eleven components and the levels of four biochemical indicators in rat plasma were continuously detected after intragastric administration of nine formulations, respectively. The collected …

Cryptocaryone Induces Apoptosis In Human Hepatocellular Carcinoma Cells By Inhibiting Aerobic Glycolysis Through Akt And C-Src Signaling Pathways, Chen-Lin Yu, Yu-Wei Lai, Jih-Jung Chen, Jie-Jen Lee, Tsung-Hsien Chou, Chen-Chen Huang, Shih-Chia Liu, Guang-Wei Chen, Chung‐Hsin Tsai, Shih-Wei Wang

Journal of Food and Drug Analysis

Hepatocellular carcinoma (HCC) is the most common form of liver cancer, with the second highest mortality rate in all cancer. Energy reprogramming is one of the hallmarks of cancer, and emerging evidence showed that targeting glycolysis is a promising strategy for HCC treatment. Cryptocaryone has been shown to display promising anti-cancer activity against numerous types of cancer. Previous study also indicated that cryptocaryone induces cytotoxicity by inhibiting glucose transport in cancer cells, but the detailed mechanism still needs to be elucidated. Therefore, this study aimed to investigate the relationship between the anti-cancer effect and glycolytic metabolism of cryptocaryone in human …

Dehulled Adlay (Coix Lachryma-Jobi L.) Ameliorates Hepatic Gluconeogenesis And Steatosis In Streptozotocin/High-Fat Diet-Induced Diabetic Rats, Shing-Hwa Liu, Wan-Hsin Wu, Huei-Ping Tzeng, Wenchang Chiang, Meng-Tsan Chiang

Journal of Food and Drug Analysis

Adlay (Coix lachryma-jobi L.) is a traditional Chinese herbal medicine with various biological activities. We investigated the anti-diabetic effects of different parts of adlay seeds, including polished adlay (PA), adlay bran (AB) and dehulled adlay (DA) in a streptozotocin (STZ)/high fat diet (HFD) diabetic rat model (DM). DM rats supplemented with or without PA (43%), AB (3%), or DA (46%) diet for 8 weeks. The plasma glucose and insulin levels and the insulin resistance index (HOMA-IR) were increased in DM group; among the three adlay diets, DA has the best effects attenuating all of these alterations in DM …

Biological And Clinical Significance Of The Age-Rage Axis In The Aggressiveness And Prognosis Of Prostate Cancer, Shih-Hong Khoo, Pei-Ru Wu, Kun-Tu Yeh, Shih-Lan Hsu, Chi-Hao Wu

Journal of Food and Drug Analysis

Dietary factors and chronic hyperglycemia are linked to the formation of advanced glycation end products (AGEs) and prostate cancer (PCa) risk. The activation of the receptor for AGEs (RAGE) acts as a bridge between various RAGE ligands and certain malignancies. This study showed that the interaction of AGEs and RAGE promoted PCa cell proliferation, invasion, and autophagy-mediated survival in response to chemotherapeutic agents. RAGE-overexpressed PCa cells underwent epithelial-mesenchymal transition and showed increased cancer stem cell-like properties. In mouse xenograft models, RAGE-overexpressed cells showed more substantial tumorigenic capacity than parental cells, whereas RAGE knockdown decreased tumorigenicity. The clinical data validated a …

Steamed Daylily Flower (Hemerocallis Fulva L.) Protected Cardiac And Hepatic Cells Against Ethanol Induced Apoptotic And Oxidative Damage, Sheng-Lei Yan, Wen-Tzu Wu, Mei-Chin Mong, Mei-Chin Yin

Journal of Food and Drug Analysis

Our previous study examined the phytochemical composition and bio-activities of raw daylily flower (Hemerocallis fulva L.). However, this plant food is usually served via heat process such as cooking in a soup. This study aimed to investigate the phytochemical profile and biofunctions of steamed daylily flower (SDF). The content of total phenolic acids, total flavonoids, total carotenoids, total anthocyanins and total triterpenoids in SDF aqueous extract was assessed. Normal cardiac and hepatic cells, H9c2 and L-02 cells, were used to evaluate the protective effects of SDF against ethanol. SDF concentrations of 0.25%, 0.5%, and 1% were applied to treat …

Analysis And Identification Of Phenolic Compounds With Antiproliferative Activity From Chinese Olive (Canarium Album L.) Fruit Extract By Hplc-Dad-Spe-Tt-Nmr, Yu-Te Yeh, Chien-Kuang Chen, Yi-Chun Liao, Shoei-Sheng Lee, Shu-Chen Hsieh

Journal of Food and Drug Analysis

Chinese olives (Canarium album L.) are rich in phenolic compounds, exhibiting a broad spectrum of potential clinical applications. This study is the first report on the isolation and elucidation of bioactive compounds with high antiproliferative activity from the ethyl acetate fraction of a Chinese olive fruit methanolic extract (CO-EtOAc). We used the WST-1 assay to determine which subfractions of CO-EtOAc had significant antiproliferative activity using the murine colon cancer cell line CT26. Subsequently, the functional compounds were characterized by the hyphenated technique and high-performance liquid chromatography-diode array detector-solid phase extraction-transfer tube-nuclear magnetic resonance (HPLC-DAD-SPE-TT-NMR). Thirteen phenolic constituents were identified …

Glycine-Rich Peptides From Fermented Chenopodium Formosanum Sprout As An Antioxidant To Modulate The Oxidative Stress, Chen-Che Hsieh, Shu-Han Yu, Hsing-Chun Kuo, Darin Khumsupan, Hsiao-Chu Huang, Yu-Wei Liou, Chen-Yu Kao, Szu-Chuan Shen, Kuan-Chen Cheng

Journal of Food and Drug Analysis

Rhizopus oligosporus was utilized in the solid-state fermentation of Chenopodium formosanum sprouts (FCS) in a bioreactor. Subsequently, the antioxidant activity of food proteins derived from FCS was investigated. Results showed that glycine-rich peptide (GGGGGKP, G-rich peptide), identified from the < 2 kDa FCS proteins, had antioxidant values. According to SwissADME, AllerTOP, ToxinPred, and BIOPEP-UWM analyses, G-rich peptide was identified as safe, non-toxic, and non-allergenic. Afterward, the peptide was examined using in silico and in vitro studies to evaluate its potential alleviating oxidative stress caused by particulate matter. This study proposed plausible mechanisms that involve the binding of G-rich peptide which inhibited phosphorylation of the v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) subunit on NF-κB pathway. The inhibition then resulted in down regulation of NF-κB transcription and genetic expression of inflammatory …

Abundance Of Prevotella Copri In Gut Microbiota Is Inversely Related To A Healthy Diet In Patients With Type 2 Diabetes, Chih-Yiu Tsai, Po-Yu Liu, Meng-Chuan Huang, Chiao-I Chang, Hsin-Yun Chen, Yu-Hsien Chou, Chi-Neu Tsai, Chia-Hung Lin

Journal of Food and Drug Analysis

While the gut microbiota is known to be influenced by habitual food intake, this relationship is seldom explored in type 2 diabetes patients. This study aims to investigate the relationship between dietary patterns and gut microbial species abundance in 113 type 2 diabetes patients (mean age, 58 years; body mass index, 29.1; glycohemoglobin [HbA1c], 8.1%). We analyzed the gut microbiota using 16S amplicon sequencing, and all patients were catogorized into either the Bacteroides enterotype (57.5%, n = 65) or the Prevotella enterotype (42.5%, n = 48) using the partitioning around medoids clustering algorithm, based on the most representative genera. Patients …