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Target Identification And Validation Of The Alpha7 Nicotinic Acetylcholine Receptor As A Potential Therapeutic Target In Retinal Disease, David M. Linn

Open Access Publishing Support Funded Articles

The role of acetylcholine (ACh) in visual processing in the mammalian retina has been the focus of research for many decades. Pioneering work on the localization of ACh discovered that the neurotransmitter is synthesized and stored in a distinct subpopulation of amacrine (starburst) cells. It has been shown that ACh release is regulated to a low resting “tonic” level, much like what is observed at the neuromuscular junction (NMJ). If there were a dysfunction in the tonic release of ACh, might post-synaptic changes render the targets of ACh [i.e., retinal ganglion cells (RGCs)] vulnerable to disease? During my time at …

Constitutive Als3 Expression In Candida Albicans Enhances Adhesion And Biofilm Formation Of Efg1, But Not Cph1 Mutant Strains, Nicholas C. Schena, Kassandra M. Baker, Anna A. Stark, Derek Thomas, Ian Cleary

Open Access Publishing Support Funded Articles

Adhesion to living and non-living surfaces is an important virulence trait of the fungal pathogen Candida albicans. Biofilm formation in this organism depends on the expression of a number of cell surface proteins including the hypha-specific protein Als3p. Loss of ALS3 impairs biofilm formation and decreases cell-cell adhesion. We wanted to test whether constitutively expressing ALS3 could compensate for defects in adhesion and biofilm formation observed in mutant strains that lack key transcriptional regulators of biofilm formation Efg1p and Cph1p. We found that ALS3 improved adhesion and biofilm formation in the efg1Δ and efg1Δ cph1Δ mutant …

Hippocampal Volume And The Detection Of Mild Cognitive Impairment In An Older Adult Population: Assessing Performance On Cognitive Screeners Administered In-Person And Electronically, Kristen Fabrizi

Dissertations

The present study investigated how performance on in-person and electronic neuropsychological assessment measures predicted subcortical hippocampal volume and cognitive decline consistent with mild cognitive impairment. It was hypothesized that the Montreal Cognitive Assessment would display better predictive strength than the Cogstate Brief Battery when evaluating subcortical hippocampal volume measured via structural magnetic resonance imaging. It was further hypothesized that the Montreal Cognitive Assessment would be more sensitive to predicting group membership to the diagnostic classification of mild cognitive impairment compared to the Cogstate Brief Battery. The sample included 445 older adult participants selected from the Alzheimer’s Disease Neuroimaging Initiative 3. …

Diffractive Light And Solar Sails, Prateek Ranjan Srivastava

Theses

In the realm of space exploration, humanity has achieved remarkable feats like landing humans on the moon. However, our progress in venturing beyond our solar system has been limited. Light sails, which utilize photon momentum from laser or solar radiation, o↵er a promising propulsion technology. Unlike traditional rockets, light sails carry no fuel and can achieve high velocities and precise orbital maneuvers. In this research, we propose using an elementary space variant di↵ractive film to design passively stable light sails propelled by laser radiation. We also explore applying this concept to solar sails, enabling spiral trajectories and high orbital inclination …

Mentoring Experiences Of Undergraduate Students And Faculty Members In Science, Technology, Engineering, And Mathematics, Pamela Martínez Oquendo

School of Natural Resources: Dissertations, Theses, and Student Research

I present a comprehensive view of mentoring experiences of undergraduate students and faculty members in science, technology, engineering, and mathematics (STEM). In Chapter 1, I describe a brief outline of this dissertation. In Chapter 2, I present an interpretative phenomenological analysis of the lived experiences of former STEM undergraduate mentors of the Nebraska STEM For You (NE STEM 4U) afterschool mentoring program. In Chapter 3, I describe how the ramifications of faculty mentorship influence the science pipeline using a qualitative synthesis. In Chapter 4, I describe how the STEM faculty-student mentoring engagement involves a strong psychological support component using a …

The Effects Of Temperature And Flooding Duration On The Structure And Magnitude Of A Floodplain Prey Subsidy, Ryan J. Rezek, Jordan A. Massie, James A. Nelson, Rolando O. Santos, Natasha M. Viadero, W. Ryan James, Ross E. Boucek, Jennifer S. Rehage

Marine Science

Riverine floodplains serve as an important link between terrestrial and aquatic systems, as the rising and falling of water drive spatial food web subsidies that are critical to the functioning and stability of ecosystems. As these systems are increasingly impacted by hydrological alterations and climate change, it is important to understand how floodplain spatial food web subsidies may respond to changing environmental conditions.

Here, we examine the interannual variation in the structure of a sunfish (Lepomis spp.) prey subsidy from freshwater marshes into the mangrove-lined creeks of Rookery Branch in the Florida Coastal Everglades that occurs during seasonal dry downs. …

Summer 2023 Graduation Survey Responses, Systems Intelligence And Data Analytics, University Of Nebraska At Omaha

Graduation

Summer 2023 Graduation survey responses master file without identifiers.

Effects Of Proprioceptive Neuromuscular Facilitation On Spine Joint Position Sense In Adolescent Idiopathic Scoliosis: A Case Report, Eunice J. Garces

Philippine Journal of Physical Therapy

Introduction. Adolescent idiopathic scoliosis (AIS), described as a complex three-dimensional spinal deformity, is thought to affect neurophysiological processes that result in a loss of proprioceptive input. The main purpose of this case study is to investigate the effect of Proprioceptive Neuromuscular Facilitation (PNF) on spine joint reposition (JR) sense in a 20-year-old with AIS.

Methods/ Case Description. The subject was a 20-year-old college student with moderate dextrothoracic and levolumbar scoliosis. She has structural scoliosis-related impaired posture, as evidenced by findings of impaired JR sensation in all directions, postural deviations, and patient-reported deformity perception using the Walter Reed Visual Assessment Scale. …

Ocean Connectivity And Habitat Characteristics Predict Population Genetic Structure Of Seagrass In An Extreme Tropical Setting, Udhi E. Hernawan, Kor-Jent Van Dijk, Gary A. Kendrick, Ming Feng, Oliver Berry, Christopher Kavazos, Kathryn Mcmahon

Research outputs 2022 to 2026

Understanding patterns of gene flow and processes driving genetic differentiation is important for a broad range of conservation practices. In marine organisms, genetic differentiation among populations is influenced by a range of spatial, oceanographic, and environmental factors that are attributed to the seascape. The relative influences of these factors may vary in different locations and can be measured using seascape genetic approaches. Here, we applied a seascape genetic approach to populations of the seagrass, Thalassia hemprichii, at a fine spatial scale (~80 km) in the Kimberley coast, western Australia, a complex seascape with strong, multidirectional currents greatly influenced by extreme …

Modulation Recognition Of Low-Snr Uav Radar Signals Based On Bispectral Slices And Ga-Bp Neural Network, Xuemin Liu, Yaoliang Song, Kuiyu Chen, Shihao Yan, Si Chen, Baihua Shi

Research outputs 2022 to 2026

In this paper, we address the challenge of low recognition rates in existing methods for radar signals from unmanned aerial vehicles (UAV) with low signal-to-noise ratios (SNRs). To overcome this challenge, we propose the utilization of the bispectral slice approach for accurate recognition of complex UAV radar signals. Our approach involves extracting the bispectral diagonal slice and the maximum bispectral amplitude horizontal slice from the bispectrum amplitude spectrum of the received UAV radar signal. These slices serve as the basis for subsequent identification by calculating characteristic parameters such as convexity, box dimension, and sparseness. To accomplish the recognition task, we …

Plasma Glial Fibrillary Acidic Protein In Autosomal Dominant Alzheimer's Disease: Associations With Aβ-Pet, Neurodegeneration, And Cognition, Pratishtha Chatterjee, Lisa Vermunt, Brian A. Gordon, Steve Pedrini, Lynn Boonkamp, Nicola J. Armstrong, Chengjie Xiong, Abhay K. Singh, Yan Li, Hamid R. Sohrabi, Kevin Taddei, Mark Molloy, Tammie L. S. Benzinger, John C. Morris, Celeste Karch, Sarah Berman, Jasmeer Chhatwal, Carlos Cruchaga, Neill R. Graff-Radford, Gregory S. Day, Martin Farlow, Nick Fox, Alison Goate, Jason Hassenstab, Jae-Hong Lee, Johannes Levin, Eric Mcdade, Hiroshi Mori, Richard Perrin, Raquel Sanchez-Valle, Peter R. Schofield, Allan Levey, Mathias Jucker, Colin L. Masters, Anne M. Fagan, Randall J. Bateman, Ralph N. Martins, Charlotte Teunissen, Dominantly Inherited Alzheimer Network

Research outputs 2022 to 2026

Background: Glial fibrillary acidic protein (GFAP) is a promising candidate blood-based biomarker for Alzheimer's disease (AD) diagnosis and prognostication. The timing of its disease-associated changes, its clinical correlates, and biofluid-type dependency will influence its clinical utility. Methods: We evaluated plasma, serum, and cerebrospinal fluid (CSF) GFAP in families with autosomal dominant AD (ADAD), leveraging the predictable age at symptom onset to determine changes by stage of disease. Results: Plasma GFAP elevations appear a decade before expected symptom onset, after amyloid beta (A ) accumulation and prior to neurodegeneration and cognitive decline. Plasma GFAP distinguished A -positive from A -negative ADAD …

Confirmatory Factor Analysis Of Two Self-Efficacy Scales For Astronomy Understanding And Robotic Telescope Use, R. Freed, David H. Mckinnon, M. T. Fitzgerald, S. Salimpour

Research outputs 2022 to 2026

This paper presents the results of a confirmatory factor analysis on two self-efficacy scales designed to probe the self-efficacy of college-level introductory astronomy (Astro-101) students (n=15181) from 22 institutions across the United States of America and Canada. The students undertook a course based on similar curriculum materials, which involved students using robotic telescopes to support their learning of astronomical concepts covered in the "traditional"Astro-101 courses. Previous research by the authors using these self-efficacy scales within a pre-/post-test approach showed both high reliabilities and very high construct validities. However, the scale purporting to measure students' self-efficacy in relation to their use …

Reprogramming Tumour-Associated Macrophages To Outcompete Cancer Cells, Xian Zhang, Shun Li, Isha Malik, Mytrang H Do, Liangliang Ji, Chun Chou, Wei Shi, Kristelle J Capistrano, Jing Zhang, Ting-Wei Hsu, Briana G Nixon, Ke Xu, Xinxin Wang, Andrea Ballabio, Laura S Schmidt, W Marston Linehan, Ming O Li

Duncan NRI Faculty and Staff Publications

In metazoan organisms, cell competition acts as a quality control mechanism to eliminate unfit cells in favour of their more robust neighbours1,2. This mechanism has the potential to be maladapted, promoting the selection of aggressive cancer cells3-6. Tumours are metabolically active and are populated by stroma cells7,8, but how environmental factors affect cancer cell competition remains largely unknown. Here we show that tumour-associated macrophages (TAMs) can be dietarily or genetically reprogrammed to outcompete MYC-overexpressing cancer cells. In a mouse model of breast cancer, MYC overexpression resulted in an mTORC1-dependent 'winner' cancer cell state. A low-protein diet inhibited mTORC1 signalling in …

Fostering Resilience Within Ecological Civilization: Contributions Of Environmental Law, Nicholas A. Robinson

Elisabeth Haub School of Law Faculty Publications

My presentation will examine water, to illustrate the questions that Ecological Civilization presents. I shall address five points: (1) Often proposals for attaining Ecological Civilization raise issues relevant to environmental law, but do not examine the roles that environmental law can serve; (2) environmental law is essential to resolving unsustainable water management issues; (3) scientific studies indicate that trends in global environmental degradation limit the time available for implementing reforms to attain Ecological Civilization; (4) environmental legal systems for environmental impact assessment (EIA) can accelerate efforts to attain Ecological Civilization; and (5) For Ecological Civilization to ensure a firm foundation …

Computational Materials Design For Ceramic Nuclear Waste Forms Using Machine Learning, First-Principles Calculations, And Kinetics Rate Theory, Jianwei Wang, Dipta B. Ghosh, Zelong Zhang

Faculty Publications

Ceramic waste forms are designed to immobilize radionuclides for permanent disposal in geological repositories. One of the principal criteria for the effective incorporation of waste elements is their compatibility with the host material. In terms of performance under environmental conditions, the resistance of the waste forms to degradation over long periods of time is a critical concern when they are exposed to natural environments. Due to their unique crystallographic features and behavior in nature environment as exemplified by their natural analogues, ceramic waste forms are capable of incorporating problematic nuclear waste elements while showing promising chemical durability in aqueous environments. …

July 2023 Louisiana Bar Exam, Louisiana Supreme Court Committee On Bar Admissions

Louisiana Bar Exams

No abstract provided.

Identification And Validation Of A Predicted Risk-Taking Propensity Model Among General Aviation Pilots, Joel Samu

Doctoral Dissertations and Master's Theses

Risk-taking, a persistent topic of interest and concern in aviation, has been linked with unsafe behaviors and accidents. However, risk-taking propensity is a complex construct that encompasses numerous factors still being researched. Even within the limited research available about the factors affecting pilots’ risk-taking propensity, studies have yielded inconsistent results. Therefore, this quantitative study explores existing and novel factors that predict the propensity for risk-taking among general aviation (GA) pilots in the United States.

This study, conducted in two stages, involved developing a prediction model using backward stepwise regression to predict pilots’ risk propensity, followed by model fit testing using …

Effect Of Nanoparticle Weight On The Cellular Uptake And Drug Delivery Potential Of Plga Nanoparticles, Prabhat Kattel, Shoukath Sulthana, JiřÍ Trousil, Dinesh Shrestha, David Pearson, Santosh Aryal

Pharmacy Faculty Publications and Presentations

Biodegradable and biocompatible polymeric nanoparticles (NPs) stand out as a key tool for improving drug bioavailability, reducing the inherent toxicity, and targeting the intended site. Most importantly, the ease of polymer synthesis and its derivatization to add functional properties makes them potentially ideal to fulfill the requirements for intended therapeutic applications. Among many polymers, US FDA-approved poly(L-lactic-co-glycolic) acid (PLGA) is a widely used biocompatible and biodegradable co-polymer in drug delivery and in implantable biomaterials. While many studies have been conducted using PLGA NPs as a drug delivery system, less attention has been given to understanding the effect of NP weight …

Do Species Matter? Examining The Niche Of White Ash (Fraxinus Americana L.) And Estimating Potential Subcanopy Effects Of Its Loss In North-Temperate Forests, Elizabeth Anne Studer

Dartmouth College Ph.D Dissertations

To understand the downstream consequences of the extinction of a species, we must understand its role in an ecosystem. With the impending extirpation of ash (Fraxinus spp.) due to the invasive emerald ash borer (Agrilus planipennis), understanding the role of ash trees is critical to predicting whether its loss will precipitate further species declines and/or ecosystem functions. We evaluated whether subcanopy microbial, invertebrate, and floral communities under four tree species (white ash, American beech, yellow birch, sugar maple) and on two soil hydropedological types (Bh podzol and Typical podzol) varied in species richness, composition, and functional traits in a factorial …

Design, Synthesis, And Redesign Of Therapeutic Peptides Using Spps, Native Chemical Ligation, And Autodock Crankpep, William Auten, Matt Womelduff, Kristopher Waynant, F. Marty Ytreberg, Darren A. Thompson

Idaho Conference on Undergraduate Research

The use of molecular modeling is quickly becoming an essential tool for the experimentalist. In this project, the molecular docking software AutoDock CrankPep (ADCP) will be utilized to analyze a variety of parameters on peptides to determine which parameters are the largest contributors in producing active compounds when synthesized experimentally and give higher accuracy to the computational results. Our hypothesis is that ADCP parameters (whose exactness we are trying to figure out) can be manipulated through inspiration from wet lab data to give scores more similar to real world values. This will then lead to faster, more efficient methods for …

Parenting During A Pandemic: Understanding The Impact Of Covid-19 On Early Childhood Development, Jessica A. Manes

Senior Theses

The early years of a child's life are crucial for their development, shaping their ability to process information, communicate, and form their identity. However, the COVID-19 pandemic disrupted essential elements necessary for optimal early childhood development, including quality education, nurturing environments, and social stimulation. This study explored how parents in South Carolina perceived the pandemic's impact on their children's development. Five themes emerged from the study. Firstly, remote work due to pandemic protocols significantly affected the parent-child relationship. Secondly, the family's socioeconomic status influenced their ability to cope with and protect their children from the pandemic's impact. Thirdly, isolation resulting …

Accreditation As A Framework For School Improvement: A Quantitavite Study, Michael A. Burroughs

Doctor of Education (Ed.D)

This study investigated the perceptions of heads of schools from accredited schools concerning whether the accreditation process, as prescribed by the League of Christian Schools (LCS), leads to improvement in leadership capacity and the impact of instruction on the learning environment. The League of Christian Schools has developed an accreditation process that is based in systems theory as espoused by Senge (2006), which contributed to the theoretical framework for this study. Administrators in LCS member K12 schools provided 25 responses to an anonymous online survey. Quantitative data were collected and analyzed to determine perceptions regarding increased organizational capacities in the …

Characterization Of Antimicrobial Properties Of Excrement And Functional Microbiome Of Black Vultures (Coragyps Atratus), Bridgette Gray

Theses

Black vultures, Coragyps atratus, are obligate scavenging birds that consume and dispose of decaying carcasses and carrion. They fulfill a key ecological niche in the environments in which they live. It has been observed that these vultures sometimes excrete bodily waste onto their legs. This adaptive behavior could help aid them in controlling bacteria and other microbes they encounter while stepping into a carcass to eat. This study directly examined the antimicrobial properties of the excrement of black vultures across various bacterial species utilizing a zone of inhibition test and a nematode species utilizing a survival assay. The black vulture …

Sports Leagues: Challenges To Enter, Maintain, And Remain, Jeffrey S. Moorad Sports Law Journal

Jeffrey S. Moorad Sports Law Journal (1994 - )

No abstract provided.

Deep Learning Classification Of Deep Ultraviolet Fluorescence Images For Margin Assessment During Breast Cancer Surgery, Tyrell To

Master's Theses (2009 -)

Breast-conserving surgery (BCS) is a widely used treatment for breast cancer, but ensuring the complete removal of cancer cells from the surgical margins remains a challenge. Deep ultraviolet (DUV) fluorescence scanning microscopy offers a potential solution by providing real-time whole-surface imaging of resected tissues during BCS. However, interpreting DUV images for margin assessment requires an automated classification method. This dissertation addresses this need by proposing a deep learning-based classification approach for DUV fluorescence images in intra-operative margin assessment of breast cancer.To overcome the limited availability of DUV image datasets and potential over- fitting, the study combines patch-level classification using transfer …

School Of Nursing Newsletter Summer 2023, Southern Adventist University

Southern Nursing - School of Nursing Newsletter

The Summer 2023 issue of the newsletter features information on the Fall 2022 NCLEX pass rate, the Costa Rica mission trip, and Miller Hall information.

Marketplace Summer 2023, Southern Adventist University

MarketPlace - School of Business Newsletter

The Summer 2023 issue of MarketPlace features information on the future of the School of Business and the university endowment. The issue features an article about Bob Jimenez, Cox Enterprises' senior vice president for corporate affairs.

Three-Dimensional Scaffolds For Bone Tissue Engineering, Harish Chinnasami, Mohan Kumar Dey, Ram Devireddy

Faculty Publications

Immobilization using external or internal splints is a standard and effective procedure to treat minor skeletal fractures. In the case of major skeletal defects caused by extreme trauma, infectious diseases or tumors, the surgical implantation of a bone graft from external sources is required for a complete cure. Practical disadvantages, such as the risk of immune rejection and infection at the implant site, are high in xenografts and allografts. Currently, an autograft from the iliac crest of a patient is considered the “gold standard” method for treating large-scale skeletal defects. However, this method is not an ideal solution due to …

Measuring Resilience To Sea-Level Rise For Critical Infrastructure Systems: Leveraging Leading Indicators, Lamis Amer, Murat Erkoc, Rusty A. Feagin, Sabarethinam Kameshwar, Katharine J. Mach, Diana Mitsova

Faculty Publications

There has been a growing interest in research on how to define and build indicators of resilience to address challenges associated with sea-level rise. Most of the proposed methods rely on lagging indicators constructed based on the historical performance of an infrastructure sub-system. These indicators are traditionally utilized to build curves that describe the past response of the sub-system to stressors; these curves are then used to predict the future resilience of the sub-system to hypothesized events. However, there is now a growing concern that this approach cannot provide the best insights for adaptive decision-making across the broader context of …

Analysis Of The Paraventricular Nucleus Of The Hypothalamus After Exposure To Decabromodiphenyl Ether In Mice, Tia Blossomgame, Hermei Herman, Sharlenn La, Jocelyn Saquisili, Annabella Vargas, Grace Martinichio, Vincent P. Markowski

McNair Scholars Program

No abstract provided.