Digital Commons Network^™

Targeting Gbm With An Oncolytic Picornavirus Svv-001 Alone And In Combination With Fractionated Radiation In A Novel Panel Of Orthotopic Pdx Models, Huiyuan Zhang, Yuchen Du, Lin Qi, Sophie Xiao, Frank K Braun, Mari Kogiso, Yulun Huang, Frank Huang, Aalaa Abdallah, Milagros Suarez, Sekar Karthick, Nabil M Ahmed, Vita S Salsman, Patricia A Baxter, Jack M Su, Daniel J Brat, Paul L Hellenbeck, Wan-Yee Teo, Akash J Patel, Xiao-Nan Li

Faculty, Staff and Students Publications

BACKGROUND: Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells. It's capacity of passing through the blood brain barrier makes is an attractive novel approach for GBM.

MATERIALS AND METHODS: 23 patient tumor samples were implanted into the brains of NOD/SCID mice (1 × 105 cells/mouse). Tumor histology, gene expression (RNAseq), and growth rate of the developed patient-derived orthotopic xenograft (PDOX) models were compared with the originating patient tumors during serial subtransplantations. Anti-tumor activities of SVV-001 were examined in vivo; and therapeutic efficacy validated …

Impact Of Blood Flow Restricted Resistance Training On Skeletal Muscle Strength, Hypertrophy, Fatigue, Mitochondrial Response, And Activation, Brett Davis

LSU Doctoral Dissertations

Abstract

Blood flow restricted resistance exercise (BFR-RE) is a novel method that is effective at increasing strength and hypertrophy using much lower loads than the higher loads typical in progressive resistance exercise. However, the effects of BFR-RE on skeletal muscle fatigue, mitochondrial response, and activation are still being explored. This dissertation will discuss the impacts of BFR-RE, how it affects college-aged individuals that are trained and untrained, and the effects of BFR-RE on skeletal muscle fatigue, mitochondrial response, and activation.

The first study examined the effects of 6-weeks of low load blood flow restricted resistance exercise (LLBFR) on muscular strength, …

High Dynamic Range 3d Motion Tracking Using Circular Scans With Optical Coherence Tomography, Senyue Hao, Marcello Magri Amaral, Chao Zhou

2020-Current year OA Pubs

Motion artifacts, from such sources as heartbeats, respiration, or peristalsis, often degrade microscopic images or videos of live subjects. We have developed a method using circular optical coherence tomography (OCT) scans to track the transverse and axial motion of biological samples at speeds ranging from several micrometers per second to several centimeters per second. We achieve fast and high-precision measurements of the magnitude and direction of the sample's motion by adaptively controlling the circular scan pattern settings and applying interframe and intraframe analyses. These measurements are the basis of active motion compensation via feedback control for future

Interactive Effects Of The Partial Pressure Of Co2, Temperature, And Nutrient-Limitation On The Physiology And Growth Of The Coccolithophore E. Huxleyi Grown On A 12:12 L:D Cycle Of Illumination, James Bradley

LSU Master's Theses

I studied the interactive effects of pCO2, temperature, and nutrient limitation on the growth and physiology of the marine coccolithophore, Emiliania huxleyi. This was done to look at the effect of climate change factors on the widespread and abundant calcifying marine organism as a predictor of what the future has to hold. The strain of E. huxleyi (PnB 272 B10) was grown on a 12:12 L:D cycle of illumination and exposed to either high or low pCO2 under nutrient-replete or nitrate-limited conditions across a temperature range of 10–28C. I examined the direct and interactive effects of temperature, pCO2, and nutrient …

Anti-Scg3 Gene Therapy To Treat Choroidal Neovascularization In Mice, Chengchi Huang, Liyang Ji, Avinash Kaur, Hong Tian, Prabuddha Waduge, Keith A Webster, Wei Li

Faculty, Staff and Students Publications

Neovascular age-related macular degeneration (nAMD) with choroidal neovascularization (CNV) is a leading cause of blindness in the elderly in developed countries. The disease is currently treated with anti-angiogenic biologics, including aflibercept, against vascular endothelial growth factor (VEGF) but with limited efficacy, treatment resistance and requirement for frequent intravitreal injections. Although anti-VEGF gene therapy may provide sustained therapy that obviates multiple injections, the efficacy and side effects related to VEGF pathway targeting remain, and alternative strategies to block angiogenesis independently of VEGF are needed. We recently reported that secretogranin III (Scg3) induces only pathological angiogenesis through VEGF-independent pathways, and Scg3-neutralizing antibodies …

Detect Misconceptions, Construct Competence-Aligned Pedagogical Practices, And Use Instructional Strategies That Decenter Speech As A Means To Include Autistic Students, Chelsea P. Tracy-Bronson, Sara Scribner

Taboo: The Journal of Culture and Education

In this practice-based article, we use data and research to establish the need to examine inclusive-oriented pedagogical strategies to support autistic individuals. We believe that educators who use critical reflection can detect many of the common misconceptions about autism, learn how to re-frame these understandings, and consider different ways to support these students within inclusive classrooms. This article provides innovative pedagogical approaches for competence-aligned instruction, cultivating a web of communication access, bolstering social interaction, and supporting changes in the environment and with sensory experiences. We also describe ways to de-center speech to create a classroom that values dynamic engagement, divergent …

Adsorptive–Photocatalytic Performance For Antibiotic And Personal Care Product Using Cu0.5Mn0.5Fe2O4, Chanat Chokejaroenrat, Chainarong Sakulthaew, Athaphon Angkaew, Apiladda Pattanateeradetch, Wuttinun Raksajit, Kanokwan Teingtham, Piyaporn Phansak, Pawee Klongvessa, Daniel D. Snow, Clifford E. Harris, Steven Comfort

Nebraska Water Center: Faculty Publications

The amount of antibiotics and personal care products entering local sewage systems and ultimately natural waters is increasing and raising concerns about long-term human health effects. We developed an adsorptive photocatalyst, Cu_0.5Mn_0.5Fe₂O₄ nanoparticles, utilizing co-precipitation and calcination with melamine, and quantified its efficacy in removing paraben and oxytetracycline (OTC). During melamine calcination, Cu_0.5Mn_0.5Fe₂O₄ recrystallized, improving material crystallinity and purity for the adsorptive–photocatalytic reaction. Kinetic experiments showed that all four parabens and OTC were removed within 120 and 45 min. We found that contaminant adsorption and reaction …

The Impact Of Road Crossings On Karst Headwater Streams In Northwest Arkansas, Anthony M. Zenga

ATU Theses and Dissertations 2021 - Present

The karst region of NW Arkansas is home to many headwater endemic Species of Greatest Conservation Need (SGCN). This includes many species of darters, such as Etheostoma cragini, E. microperca, and E. mihileze, as well as crayfish such as Faxonious meeki brevis and F. nana. NW Arkansas is rapidly urbanizing, increasing the need to construct structures like culverts, bridges, and fords. These man-made road crossings can cause stream habitat degradation and fragmentation, as well as impair overall stream connectivity. To evaluate the impact that road crossings have on aquatic SGCN species and their habitat, 30 headwater streams were sampled throughout …

Beyond Words: Exploring History Through The Lens Of Literary Theory And Research, Andrea Weaver

Master of Arts in English Plan II Graduate Projects

The narrative of this Master's portfolio reflects on the academic journey of Andrea Weaver. The three projects showcased in this portfolio reflect her experience during the Master of Arts in English with a Specialization in English Teaching program. It includes a rhetorical Ohio Suffragist unit plan created for high school sophomores, a seminar paper critically analyzing the film Interview with the Vampire (1994), and a digital presentation of artifacts and research about literary theorist Wolfgang Iser and his work in Reader Response Theory presented on the platform Microsoft Sway. The framework of New Historicism is threaded throughout each project, linking …

Minutes 7-5-2023 | Institutional Animal Care & Use Committee, Annette Carter

Institutional Animal Care & Use Minutes

No abstract provided.

Phenotype And Genotype Heterogeneity Of Pla2g6-Associated Neurodegeneration In A Cohort Of Pediatric And Adult Patients, Ali Zare Dehnavi, Maryam Bemanalizadeh, Seyyed Mohammad Kahani, Mahmoud Reza Ashrafi, Mohammad Rohani, Mehran Beiraghi Toosi, Morteza Heidari, Sareh Hosseinpour, Behnam Amini, Shaghayegh Zokaei, Zahra Rezaei, Hajar Aryan, Man Amanat, Hassan Vahidnezhad, Pouria Mohammadi, Masoud Garshasbi, Ali Reza Tavasoli

Department of Dermatology and Cutaneous Biology Faculty Papers

BACKGROUND: Phospholipase-associated neurodegeneration (PLAN) caused by mutations in the PLA2G6 gene is a rare neurodegenerative disorder that presents with four sub-groups. Infantile neuroaxonal dystrophy (INAD) and PLA2G6-related dystonia-parkinsonism are the main two subtypes. In this cohort, we reviewed clinical, imaging, and genetic features of 25 adult and pediatric patients harboring variants in the PLA2G6.

METHODS: An extensive review of the patients' data was carried out. Infantile Neuroaxonal Dystrophy Rating Scale (INAD-RS) was used for evaluating the severity and progression of INAD patients. Whole-exome sequencing was used to determine the disease's underlying etiology followed by co-segregation analysis using Sanger sequencing. In …

Yes-Associated Protein-1 Overexpression In Ocular Surface Squamous Neoplasia; A Potential Diagnostic Marker And Therapeutic Target, Peter Julius, Stepfanie N. Siyumbwa, Fred Maate, Phyllis Moonga, Guobin Kang, Trevor Kaile, John T. T., Charles Wood

Nebraska Center for Virology: Faculty Publications

Yes-associated protein-1 (YAP-1) is a Hippo system transcription factor, which serves as an oncogene in squamous cell carcinoma, and several solid tumors when the Hippo pathway is dysregulated. Yet, the activity of YAP-1 in ocular surface squamous neoplasia (OSSN) has not been determined. Here, we investigate the relationship between YAP-1 overexpression and OSSN. Using a cross-sectional study design, we recruited 227 OSSN patients from the University Teaching Hospitals in Lusaka, Zambia. Immunohistochemistry was used to assess YAP-1 protein overexpression in tumor tissue relative to surrounding benign squamous epithelium. OSSN patient samples (preinvasive, n = 62, 27% and invasive, n = …

Antimicrobial Resistance: A Growing Serious Threat For Global Public Health, Md Abdus Salam, Md Yusuf Al-Amin, Moushumi Tabassoom Salam, Jogendra Singh Pawar, Naseem Akhter, Ali A. Rabaan, Mohammed A. A Alqumber

Neurology Articles

Antibiotics are among the most important discoveries of the 20th century, having saved millions of lives from infectious diseases. Microbes have developed acquired antimicrobial resistance (AMR) to many drugs due to high selection pressure from increasing use and misuse of antibiotics over the years. The transmission and acquisition of AMR occur primarily via a human-human interface both within and outside of healthcare facilities. A huge number of interdependent factors related to healthcare and agriculture govern the development of AMR through various drug-resistance mechanisms. The emergence and spread of AMR from the unrestricted use of antimicrobials in livestock feed has been …

An Immunostimulatory Glycolipid That Blocks Sars-Cov-2, Rsv, And Influenza Infections In Vivo, Moriya Tsuji, Zhenlu Chong, Tamarand L Darling, Kuljeet Seehra, Adrianus C M Boon, Michael S Diamond, Et Al.

2020-Current year OA Pubs

Prophylactic vaccines for SARS-CoV-2 have lowered the incidence of severe COVID-19, but emergence of viral variants that are antigenically distinct from the vaccine strains are of concern and additional, broadly acting preventive approaches are desirable. Here, we report on a glycolipid termed 7DW8-5 that exploits the host innate immune system to enable rapid control of viral infections in vivo. This glycolipid binds to CD1d on antigen-presenting cells and thereby stimulates NKT cells to release a cascade of cytokines and chemokines. The intranasal administration of 7DW8-5 prior to virus exposure significantly blocked infection by three different authentic variants of SARS-CoV-2, as …

Why China Cares About Canada’S Indigenous Residential Schools: From Whataboutism To Internal Denial, Xiyuan (Marvin) Xia

Genocide Studies and Prevention: An International Journal

This article examines how the Chinese government and its propaganda departments use genocide-related discourses to fulfil different political purposes at home and abroad. By criticizing Western colonialist regimes’ assimilation policies, especially Canada’s Indigenous residential schools, the Chinese diplomats apply the rhetoric of whataboutism to dodge the international community’s questions about China’s systematic persecution of Uyghur Muslims. Domestically, China’s state media intensively cover Canada’s residential school system and the colonial genocide against Indigenous people, trying to distract the audience from the state atrocities in Xinjiang and mislead the public to distrust Canada and other countries’ motives for accusing China of committing …

Tiam1 Coordinates Synaptic Structural And Functional Plasticity Underpinning The Pathophysiology Of Neuropathic Pain, Lingyong Li, Qin Ru, Yungang Lu, Xing Fang, Guanxing Chen, Ali Bin Saifullah, Changqun Yao, Kimberley F Tolias

Faculty, Staff and Students Publications

Neuropathic pain is a common, debilitating chronic pain condition caused by damage or a disease affecting the somatosensory nervous system. Understanding the pathophysiological mechanisms underlying neuropathic pain is critical for developing new therapeutic strategies to treat chronic pain effectively. Tiam1 is a Rac1 guanine nucleotide exchange factor (GEF) that promotes dendritic and synaptic growth during hippocampal development by inducing actin cytoskeletal remodeling. Here, using multiple neuropathic pain animal models, we show that Tiam1 coordinates synaptic structural and functional plasticity in the spinal dorsal horn via actin cytoskeleton reorganization and synaptic NMDAR stabilization and that these actions are essential for the …

Yes-Associated Protein-1 Overexpression In Ocular Surface Squamous Neoplasia; A Potential Diagnostic Marker And Therapeutic Target, Peter Julius, Stepfanie N. Siyumbwa, Fred Maate, Phyllis Moonga, Guobin Kang, Trevor Kaile, John T. West, Charles Wood, Peter C. Angeletti

School of Graduate Studies Faculty Publications

Yes-associated protein-1 (YAP-1) is a Hippo system transcription factor, which serves as an oncogene in squamous cell carcinoma, and several solid tumors when the Hippo pathway is dysregulated. Yet, the activity of YAP-1 in ocular surface squamous neoplasia (OSSN) has not been determined. Here, we investigate the relationship between YAP-1 overexpression and OSSN. Using a cross-sectional study design, we recruited 227 OSSN patients from the University Teaching Hospitals in Lusaka, Zambia. Immunohistochemistry was used to assess YAP-1 protein overexpression in tumor tissue relative to surrounding benign squamous epithelium. OSSN patient samples (preinvasive, n = 62, 27% and invasive, n = …

Fibrosis-The Tale Of H3k27 Histone Methyltransferases And Demethylases, Morgan D. Basta, Svetlana Petruk, Alexander Mazo, Janice L. Walker

Department of Biochemistry and Molecular Biology Faculty Papers

Fibrosis, or excessive scarring, is characterized by the emergence of alpha-smooth muscle actin (αSMA)-expressing myofibroblasts and the excessive accumulation of fibrotic extracellular matrix (ECM). Currently, there is a lack of effective treatment options for fibrosis, highlighting an unmet need to identify new therapeutic targets. The acquisition of a fibrotic phenotype is associated with changes in chromatin structure, a key determinant of gene transcription activation and repression. The major repressive histone mark, H3K27me3, has been linked to dynamic changes in gene expression in fibrosis through alterations in chromatin structure. H3K27-specific homologous histone methylase (HMT) enzymes, Enhancer of zeste 1 and 2 …

Assessment Of The Immune Response In Patients With Insulin Resistance, Obesity, And Diabetes To Covid-19 Vaccination, Jędrzej Warpechowski, Paula Leszczyńska, Dominika Juchnicka, Adam Olichwier, Łukasz Szczerbiński, Adam Jacek Krętowski

Department of Nutrition and Health Sciences: Faculty Publications

The SARS-CoV-19 pandemic overwhelmed multiple healthcare systems across the world. Patients with underlying medical conditions such as obesity or diabetes were particularly vulnerable, had more severe symptoms, and were more frequently hospitalized. To date, there have been many studies on the severity of SARS-CoV-2 in patients with metabolic disorders, but data on the efficiency of vaccines against COVID-19 are still limited. This paper aims to provide a comprehensive overview of the effectiveness of COVID-19 vaccines in individuals with diabetes, insulin resistance, and obesity. A comparison is made between the immune response after vaccination in patients with and without metabolic comorbidities. …

Pcos Health-Related Quality-Of-Life And Depressive Symptoms Across The Lifespan: Comparative Study, Pamela J. Wright Phd, Ms, Med, Rn, Cen, Abbas S. Tavakoli, Cynthia F. Corbett Phd, Rn, Faan

Publications

The purpose of this cross-sectional study was to compare health-related quality of life (HRQoL) and depressive symptoms among peri-postmenopausal women with polycystic ovary syndrome (PCOS) aged ≥43 years relative to premenopausal women with PCOS aged 18-42 years. An online survey link comprising questionnaires about demographics, HRQoL, and depressive symptoms was posted onto two PCOS-specific Facebook groups. Respondents (n = 1,042) were separated into two age cohorts: women with PCOS aged 18-42 years (n = 935) and women with PCOS aged ≥43 years (n = 107). Data from the online survey were analyzed using descriptive statistics, Pearson correlations, and multiple regression …

Synthesis, Electrochemical And Photochemical Properties Of Sulfanyl Porphyrazine With Ferrocenyl Substituents, Mina Hassani, Amanda Leda, Weronika Porolnik, Michal Falkowski, Tomasz Rębiś, Jaroslaw Piskorz, Lukasz Popenda, Michal Wicinski, Dariusz T. Mlynarczyk, Nejat Düzgüneş, Michal P. Marszall

Pacific Faculty Work

Ferrocene is useful in modern organometallic chemistry due to its versatile applications in material sciences, catalysis, medicinal chemistry, and diagnostic applications. The ferrocene moiety can potentially serve many purposes in therapeutics and diagnostics. In the course of this study, (6-bromo-1-oxohexyl)ferrocene was combined with dimercaptomaleonitrile sodium salt to yield a novel maleonitrile derivative. Subsequently, this compound was subjected to an autocyclotetramerization reaction using the Linstead conditions in order to obtain an octaferrocenyl-substituted magnesium(II) sulfanyl porphyrazine. Following that, both compounds—the maleonitrile derivative and the porphyrazine derivative—were subjected to physicochemical characterization using UV-Vis, ES-TOF, MALDI-TOF, and one-dimensional and two-dimensional NMR spectroscopy. Moreover, the …

College Of Engineering News, Georgia Southern University

College of Engineering & Computing: News & Publications (2010-2023)

• Georgia Southern Redesignated as a National Security Agency Center of Academic Excellence in Cyber Defense
• Assistant Professor Frank Katz Presents at NSA-CAE Symposium in Seattle
• Eagle Team Soars at EPA P3 National Student Design Expo

Harvestable Metadata Services Development: Analysis Of Use Cases From The World Data System, Robert R. Downs, Alicia Urquidi Díaz, Qi Xu, Juanle Wang, Aude Chambodut, Chuang Liu, Simon Flower, Karen Payne

Copyright, Fair Use, Scholarly Communication, etc.

Minimally, a research data repository exists to make a collection of data assets available to potential users. If a dataset cannot be discovered and found, it cannot be reused (Garnett et al. 2017). Harvestable metadata catalogues are a key strategy for achieving greater global findability of data assets, as they create a surveyable access point to discover data products within large data collections. Such catalogues can be especially effective if they are tailored for interoperability with feature-rich infrastructures (e.g. meta-catalogues, see Kapiszewski & Karcher 2020; CRFCB 2014) that are highly visible and widely used, and also themselves integrated within the …

Patient's Perspective Of Shared Decision-Making In Rheumatoid Arthritis Treatment: A Grounded Theory Exploration, Isabela Viana Oliveira, Mariana Martins Gonzaga Nascimento, Cristiane P. Rezende Mrs, Carina M. Neves, Hagabo Mathyell Silva, Ana Luiza Mourawad Cesar, Djenane Ramalho De Oliveira

The Qualitative Report

Current guidelines for rheumatoid arthritis (RA) treatment state that all decisions should be shared with the patient. Therefore, it becomes necessary to understand in-depth how patients with RA with different levels of health literacy and activation feel about sharing the decision with the health professional and how they experience this process. Grounded theory was used. Data collection included semi-structured interviews with 14 patients with RA. From the analysis of the patients’ narratives, four categories were built: “Accepting the changes: non-shared decisions”; “The patient's rationale: why not share?”; “Reaching the requirements for sharing the decision: expanding the patient’s autonomy"; and "Experiencing …

Optimizing The Membrane-Assisted Recovery Of Solids (Mars) Technology For Nutrient Removal And Recovery From Concentrated Waste Streams, Ben Yamin Hoque

USF Tampa Graduate Theses and Dissertations

The effective management of nutrients, such as nitrogen and phosphorus, in decentralizedwastewater treatment environments is a pressing challenge. These nutrients pose significant risks to the environment and public health when discharged into water bodies, while their recovery and reuse can help alleviate nutrient shortages in various industries, including agriculture. Conventional biological treatment methods used in centralized facilities are not suitable for decentralized systems due to operational complexities and space limitations. Chemical treatment mechanisms, such as adsorption, ion exchange, precipitation, and air-stripping, offer potential solutions but are accompanied by challenges like high costs and logistical issues. Therefore, finding a sustainable and …

Defining A Factor-Induced Signaling Signature For Endothelial Tubulogenesis, Sprouting, And Pericyte Recruitment, Prisca Kuanting Lin

USF Tampa Graduate Theses and Dissertations

Endothelial cells (ECs) form the inner lining of blood capillary walls. Our laboratory has developed a serum-free, defined Factor system that allows for human ECs to sprout, form lumens and tube networks, recruit pericytes, and induce capillary basement membrane deposition in 3D extracellular matrices. We have shown that the Factor system drives morphogenesis through the activation of multiple signaling pathways; however, we do not know if all factors in the Factor system are needed to induce maximal EC morphogenesis. If so, we have yet to identify why the Factors are critical to the model other than that they induce activation …

Catalytic Enantioselective Synthesis Of 3-Piperidines From Arylboronic Acids And Pyridine, Sourabh Mishra, Sedef Karabiyikoglu, Stephen P Fletcher

Faculty, Staff and Student Publications

Piperidines are frequently found in natural products and are of importance to the pharmaceutical industry. A generally useful asymmetric route to enantiomerically enriched 3-substituted piperidines remains elusive. Here we report a cross-coupling approach to enantioenriched 3-piperidines from pyridine- and sp²-hybridized boronic acids. The key step involves a Rh-catalyzed asymmetric reductive Heck reaction of aryl, heteroaryl, or vinyl boronic acids and phenyl pyridine-1(2H)-carboxylate to provide 3-substituted tetrahydropyridines in high yield and excellent enantioselectivity with a wide functional group tolerance. A three-step process involving i) partial reduction of pyridine, ii) Rh-catalyzed asymmetric carbometalation, and then iii) another reduction …

Accuracy Of Baseline Prevalence Estimates For Sample-Size Calculations In Randomized Controlled Trials, Andrew Aultman, Kelly C Ditter, Hector Mendez-Figueroa, Megha Gupta, Michal Fishel Bartal, Suneet P Chauhan, Stephen Wagner

Faculty, Staff and Student Publications

No abstract provided.

A Phase Ib/Ii Study Of Ivosidenib With Venetoclax ± Azacitidine In Idh1-Mutated Myeloid Malignancies, Curtis A Lachowiez, Sanam Loghavi, Zhihong Zeng, Tomoyuki Tanaka, Yi June Kim, Hidetaka Uryu, Sven Turkalj, Niels Asger Jakobsen, Marlise R Luskin, Dzifa Y Duose, Rebecca S S Tidwell, Nicholas J Short, Gautam Borthakur, Tapan M Kadia, Lucia Masarova, George D Tippett, Prithviraj Bose, Elias J Jabbour, Farhad Ravandi, Naval G Daver, Guillermo Garcia-Manero, Hagop Kantarjian, Jacqueline S Garcia, Paresh Vyas, Koichi Takahashi, Marina Konopleva, Courtney D Dinardo

Faculty, Staff and Student Publications

UNLABELLED: The safety and efficacy of combining the isocitrate dehydrogenase-1 (IDH1) inhibitor ivosidenib (IVO) with the BCL2 inhibitor venetoclax (VEN; IVO + VEN) ± azacitidine (AZA; IVO + VEN + AZA) were evaluated in four cohorts of patients with IDH1-mutated myeloid malignancies (n = 31). Most (91%) adverse events were grade 1 or 2. The maximal tolerated dose was not reached. Composite complete remission with IVO + VEN + AZA versus IVO + VEN was 90% versus 83%. Among measurable residual disease (MRD)-evaluable patients (N = 16), 63% attained MRD--negative remissions; IDH1 mutation clearance occurred in 64% of patients receiving …

Office Of Research, Economic Engagement And Outreach Update, July 5, 2023, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.