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2023

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Dynamic Mapping Of Proteome Trafficking Within And Between Living Cells By Transitid, Wei Qin, Joleen S Cheah, Charles Xu, James Messing, Brian D Freibaum, Steven Boeynaems, J Paul Taylor, Namrata D Udeshi, Steven A Carr, Alice Y Ting Jul 2023

Dynamic Mapping Of Proteome Trafficking Within And Between Living Cells By Transitid, Wei Qin, Joleen S Cheah, Charles Xu, James Messing, Brian D Freibaum, Steven Boeynaems, J Paul Taylor, Namrata D Udeshi, Steven A Carr, Alice Y Ting

Faculty, Staff and Students Publications

The ability to map trafficking for thousands of endogenous proteins at once in living cells would reveal biology currently invisible to both microscopy and mass spectrometry. Here, we report TransitID, a method for unbiased mapping of endogenous proteome trafficking with nanometer spatial resolution in living cells. Two proximity labeling (PL) enzymes, TurboID and APEX, are targeted to source and destination compartments, and PL with each enzyme is performed in tandem via sequential addition of their small-molecule substrates. Mass spectrometry identifies the proteins tagged by both enzymes. Using TransitID, we mapped proteome trafficking between cytosol and mitochondria, cytosol and nucleus, and …

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A Novel Statistical Method For Decontaminating T-Cell Receptor Sequencing Data, Ruoxing Li, Mehmet Altan, Alexandre Reuben, Ruitao Lin, John V Heymach, Hai Tran, Runzhe Chen, Latasha Little, Shawna Hubert, Jianjun Zhang, Ziyi Li Jul 2023

A Novel Statistical Method For Decontaminating T-Cell Receptor Sequencing Data, Ruoxing Li, Mehmet Altan, Alexandre Reuben, Ruitao Lin, John V Heymach, Hai Tran, Runzhe Chen, Latasha Little, Shawna Hubert, Jianjun Zhang, Ziyi Li

Faculty, Staff and Student Publications

The T-cell receptor (TCR) repertoire is highly diverse among the population and plays an essential role in initiating multiple immune processes. TCR sequencing (TCR-seq) has been developed to profile the T cell repertoire. Similar to other high-throughput experiments, contamination can happen during several steps of TCR-seq, including sample collection, preparation and sequencing. Such contamination creates artifacts in the data, leading to inaccurate or even biased results. Most existing methods assume 'clean' TCR-seq data as the starting point with no ability to handle data contamination. Here, we develop a novel statistical model to systematically detect and remove contamination in TCR-seq data. …

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Measuring And Enhancing The Ionic Conductivity Of Chloroaluminate Electrolytes For Al-Ion Batteries, Anthony J Lucio, Iwan Sumarlan, Elena Bulmer, Igor Efimov, Stephen Viles, A Robert Hillman, Christopher J Zaleski, Karl S Ryder Jul 2023

Measuring And Enhancing The Ionic Conductivity Of Chloroaluminate Electrolytes For Al-Ion Batteries, Anthony J Lucio, Iwan Sumarlan, Elena Bulmer, Igor Efimov, Stephen Viles, A Robert Hillman, Christopher J Zaleski, Karl S Ryder

Faculty, Staff and Student Publications

At the core of the aluminum (Al) ion battery is the liquid electrolyte, which governs the underlying chemistry. Optimizing the rheological properties of the electrolyte is critical to advance the state of the art. In the present work, the chloroaluminate electrolyte is made by reacting AlCl3 with a recently reported acetamidinium chloride (Acet-Cl) salt in an effort to make a more performant liquid electrolyte. Using AlCl3:Acet-Cl as a model electrolyte, we build on our previous work, which established a new method for extracting the ionic conductivity from fitting voltammetric data, and in this contribution, we validate the method across a …

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Structures Of Channelrhodopsin Paralogs In Peptidiscs Explain Their Contrasting K+ And Na+ Selectivities, Takefumi Morizumi, Kyumhyuk Kim, Hai Li, Elena G Govorunova, Oleg A Sineshchekov, Yumei Wang, Lei Zheng, Éva Bertalan, Ana-Nicoleta Bondar, Azam Askari, Leonid S Brown, John L Spudich, Oliver P Ernst Jul 2023

Structures Of Channelrhodopsin Paralogs In Peptidiscs Explain Their Contrasting K+ And Na+ Selectivities, Takefumi Morizumi, Kyumhyuk Kim, Hai Li, Elena G Govorunova, Oleg A Sineshchekov, Yumei Wang, Lei Zheng, Éva Bertalan, Ana-Nicoleta Bondar, Azam Askari, Leonid S Brown, John L Spudich, Oliver P Ernst

Faculty, Staff and Student Publications

Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) is a light-gated channel used for optogenetic silencing of mammalian neurons. It selects K+ over Na+ in the absence of the canonical tetrameric K+ selectivity filter found universally in voltage- and ligand-gated channels. The genome of H. catenoides also encodes a highly homologous cation channelrhodopsin (HcCCR), a Na+ channel with >100-fold larger Na+ to K+ permeability ratio. Here, we use cryo-electron microscopy to determine atomic structures of these two channels embedded in peptidiscs to elucidate structural foundations of their dramatically different cation selectivity. Together with structure-guided mutagenesis, we show …

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Multi-Campaign Ship And Aircraft Observations Of Marine Cloud Condensation Nuclei And Droplet Concentrations, Kevin J Sanchez, David Painemal, Matthew D Brown, Ewan C Crosbie, Francesca Gallo, Johnathan W Hair, Chris A Hostetler, Carolyn E Jordan, Claire E Robinson, Amy Jo Scarino, Taylor J Shingler, Michael A Shook, Kenneth L Thornhill, Elizabeth B Wiggins, Edward L Winstead, Luke D Ziemba, Scott Chambers, Alastair Williams, Ruhi S Humphries, Melita D Keywood, Jason P Ward, Luke Cravigan, Ian M Mcrobert, Connor Flynn, Gourihar R Kulkarni, Lynn M Russell, Gregory C Roberts, Greg M Mcfarquhar, Athanasios Nenes, Sarah F Woods, Jeffery S Reid, Jennifer Small-Griswold, Sarah Brooks, Simon Kirschler, Christianne Voigt, Jian Wang, David J Delene, Patricia K Quinn, Richard H Moore Jul 2023

Multi-Campaign Ship And Aircraft Observations Of Marine Cloud Condensation Nuclei And Droplet Concentrations, Kevin J Sanchez, David Painemal, Matthew D Brown, Ewan C Crosbie, Francesca Gallo, Johnathan W Hair, Chris A Hostetler, Carolyn E Jordan, Claire E Robinson, Amy Jo Scarino, Taylor J Shingler, Michael A Shook, Kenneth L Thornhill, Elizabeth B Wiggins, Edward L Winstead, Luke D Ziemba, Scott Chambers, Alastair Williams, Ruhi S Humphries, Melita D Keywood, Jason P Ward, Luke Cravigan, Ian M Mcrobert, Connor Flynn, Gourihar R Kulkarni, Lynn M Russell, Gregory C Roberts, Greg M Mcfarquhar, Athanasios Nenes, Sarah F Woods, Jeffery S Reid, Jennifer Small-Griswold, Sarah Brooks, Simon Kirschler, Christianne Voigt, Jian Wang, David J Delene, Patricia K Quinn, Richard H Moore

Faculty, Staff and Student Publications

In-situ marine cloud droplet number concentrations (CDNCs), cloud condensation nuclei (CCN), and CCN proxies, based on particle sizes and optical properties, are accumulated from seven field campaigns: ACTIVATE; NAAMES; CAMP2EX; ORACLES; SOCRATES; MARCUS; and CAPRICORN2. Each campaign involves aircraft measurements, ship-based measurements, or both. Measurements collected over the North and Central Atlantic, Indo-Pacific, and Southern Oceans, represent a range of clean to polluted conditions in various climate regimes. With the extensive range of environmental conditions sampled, this data collection is ideal for testing satellite remote detection methods of CDNC and CCN in marine environments. Remote measurement methods are vital to …

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Genome-Wide Identification And Phenotypic Characterization Of Seizure-Associated Copy Number Variations In 741,075 Individuals, Ludovica Montanucci, David Lewis-Smith, Ryan L Collins, Lisa-Marie Niestroj, Shridhar Parthasarathy, Julie Xian, Shiva Ganesan, Marie Macnee, Tobias Brünger, Rhys H Thomas, Michael Talkowski, Epi25 Collaborative, Ingo Helbig, Costin Leu, Dennis Lal Jul 2023

Genome-Wide Identification And Phenotypic Characterization Of Seizure-Associated Copy Number Variations In 741,075 Individuals, Ludovica Montanucci, David Lewis-Smith, Ryan L Collins, Lisa-Marie Niestroj, Shridhar Parthasarathy, Julie Xian, Shiva Ganesan, Marie Macnee, Tobias Brünger, Rhys H Thomas, Michael Talkowski, Epi25 Collaborative, Ingo Helbig, Costin Leu, Dennis Lal

Faculty, Staff and Student Publications

Copy number variants (CNV) are established risk factors for neurodevelopmental disorders with seizures or epilepsy. With the hypothesis that seizure disorders share genetic risk factors, we pooled CNV data from 10,590 individuals with seizure disorders, 16,109 individuals with clinically validated epilepsy, and 492,324 population controls and identified 25 genome-wide significant loci, 22 of which are novel for seizure disorders, such as deletions at 1p36.33, 1q44, 2p21-p16.3, 3q29, 8p23.3-p23.2, 9p24.3, 10q26.3, 15q11.2, 15q12-q13.1, 16p12.2, 17q21.31, duplications at 2q13, 9q34.3, 16p13.3, 17q12, 19p13.3, 20q13.33, and reciprocal CNVs at 16p11.2, and 22q11.21. Using genetic data from additional 248,751 individuals with 23 neuropsychiatric phenotypes, …

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The Effects Of Psychological Distress And Retention Intervals On The Fading Affect Bias And Response Time, Kayla Yvette Mccracken Jul 2023

The Effects Of Psychological Distress And Retention Intervals On The Fading Affect Bias And Response Time, Kayla Yvette Mccracken

Electronic Theses and Dissertations Archive

The Fading Affect Bias (FAB) is a phenomenon in which emotions associated with negative memories generally tend to fade faster over time than those of positive memories. Although researchers have shown that this phenomenon tends to be reversed in individuals who are diagnosed as depressed, less is known about the degree to which varied or general levels of psychological distress impact this phenomenon. Further, less is known about the impact of varied retention intervals not only on the Fading Affect Bias, but also the degree to which the memories are recalled in a similar manner. The aim of this thesis …

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Shared Treatment Decision Making On Hyperthyroidism Among Chinese Women Planning For Pregnancy, Feifei Gu Jul 2023

Shared Treatment Decision Making On Hyperthyroidism Among Chinese Women Planning For Pregnancy, Feifei Gu

Electronic Theses and Dissertations Archive

Women of childbearing age are a high-risk group for hyperthyroidism. Although several hyperthyroidism treatment options are available, none are optimal. Women with hyperthyroidism planning to become pregnant may face the challenge of making a “trade-off” treatment decision for a future safe pregnancy. Shared treatment decision making (STDM) is an ideal model for physicians and patients to adopt in reaching an agreement and determining treatment decisions while considering the patient’s preferences, values, treatment costs and side effects. However, limited studies exist on STDM in women with hyperthyroidism before pregnancy. Therefore, this study aims to examine STDM on hyperthyroidism in Chinese women …

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Do Individuals With Benign Vocal Fold Lesions Have Increased Vocal Load Due To Nuanced Differences In Language Use?, Samantha Powell Jul 2023

Do Individuals With Benign Vocal Fold Lesions Have Increased Vocal Load Due To Nuanced Differences In Language Use?, Samantha Powell

Electronic Theses and Dissertations Archive

Individuals who engage in larger amounts of voice use have greater vocal loads, which may contribute to the development of benign vocal fold lesions (BVFL). The Personality traits of extroversion and talkativeness has been a predominant theory about increased vocal load in those with BVFL. Ambulatory monitoring has verified increased vocal use in those with BVFL, adding intensity and fundamental frequency to describe vocal load. Three vocally healthy women and three women with BVFL provided conversation and narrative language samples that underwent language analysis. Descriptive analyses of language samples revealed those with BVFL used up to twice as many words …

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Protections For All? Attitudes Toward Civil Rights Protections For Trans And Gender Non-Binary Individuals, Morgan Bailey Bullard Jul 2023

Protections For All? Attitudes Toward Civil Rights Protections For Trans And Gender Non-Binary Individuals, Morgan Bailey Bullard

Electronic Theses and Dissertations Archive

Despite the increase in visibility and recognition, the rights of LGBTQ+ people continue to be debated and politically challenged. Transgender and gender non-binary people specifically face barriers to healthcare, government documents, and public accommodations. Due to the lack of literature connecting attitudes and expansive systemic protections for this population, this study aims to examine the impact of several constructs and identify what may be critical to explore in future research as components of attitudinal change. Empathy, contact, salience of religious identity, gender role belief, political affiliation, and gender were all identified in previous literature as having a relationship with attitudes …

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Ranchsatdb: A Genome-Wide Simple Sequence Repeat (Ssr) Markers Database Of Livestock Species For Mutant Germplasm Characterization And Improving Farm Animal Health, Naveen Duhan, Simardeep Kaur, Rakesh Kaundal Jul 2023

Ranchsatdb: A Genome-Wide Simple Sequence Repeat (Ssr) Markers Database Of Livestock Species For Mutant Germplasm Characterization And Improving Farm Animal Health, Naveen Duhan, Simardeep Kaur, Rakesh Kaundal

Plants, Soils and Climate Student Research

Microsatellites, also known as simple sequence repeats (SSRs), are polymorphic loci that play an important role in genome research, animal breeding, and disease control. Ranch animals are important components of agricultural landscape. The ranch animal SSR database, ranchSATdb, is a web resource which contains 15,520,263 putative SSR markers. This database provides a comprehensive tool for performing end-to-end marker selection, from SSRs prediction to generating marker primers and their cross-species feasibility, visualization of the resulting markers, and finding similarities between the genomic repeat sequences all in one place without the need to switch between other resources. The user-friendly online interface …

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Information Literacy In The Sciences: Strategies For Engaging Undergraduate Learners In The Classroom, Justin Savage, Siobhan Mccarthy Jul 2023

Information Literacy In The Sciences: Strategies For Engaging Undergraduate Learners In The Classroom, Justin Savage, Siobhan Mccarthy

University Libraries Scholarship and Creative Works

No abstract provided.

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Current Developmental Challenges In Nepal: How Can The Diaspora Help?, Ambika P. Adhikari Jul 2023

Current Developmental Challenges In Nepal: How Can The Diaspora Help?, Ambika P. Adhikari

Himalayan Research Papers Archive

Nepal now enjoys a unique opportunity to positively transform the country’s economy and society. The economic activities fueled by remittance, supported by foreign aid, and aided by domestic economic activities such as tourism, trade, and services, including start-ups, are helping increase individual incomes. However, the earnings from remittances, which measure to about 25% of Nepal’s GDP, are spent on consumer goods and not on investments that can generate employment and raise the standards of living. The foreign aid is often donor driven and also not always well managed and wisely spent on national priorities. Further, it is frequently marred by …

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Hsc Connects Newsletter - July 20, 2023, Unm Hsc Communications Jul 2023

Hsc Connects Newsletter - July 20, 2023, Unm Hsc Communications

HSC Connects Newsletters

Weekly newsletter of the UNM Health Sciences Center.

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China’S Governance: Strategy Choice And Future Vision For Combating Desertification, Guipeng Cui, Chunlei Xiao, Jiaqiang Lei, Xiaosong Li, Yingshuang Bao, Qi Lu Jul 2023

China’S Governance: Strategy Choice And Future Vision For Combating Desertification, Guipeng Cui, Chunlei Xiao, Jiaqiang Lei, Xiaosong Li, Yingshuang Bao, Qi Lu

Bulletin of Chinese Academy of Sciences (Chinese Version)

China has made remarkable achievements in combating desertification over the past 70 years. At present, China has entered a new stage of combating desertification while facing many problems such as large desertification land base and high difficulty in combating desertification, and it is more important to meet the national strategic needs of ecological construction, rural revitalization, and the development and utilization of renewable energy in desert, Gobi, and wasteland areas. The strategic choice of combating desertification in China in the new era is overall improvement and key breakthroughs. The core of the strategy is whole-area governance, innovation-driven, and technology integration. …

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Connotation And Countermeasures Of Scientific Research Paradigm Transformation In The New Era, Peng Du, Bingyu Zhao, Li Sun, Xiaojing Sha, Liqian Zhang, Zidan Wang Jul 2023

Connotation And Countermeasures Of Scientific Research Paradigm Transformation In The New Era, Peng Du, Bingyu Zhao, Li Sun, Xiaojing Sha, Liqian Zhang, Zidan Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The purpose of this study is to comprehensively explore the main connotation and important impact of scientific research paradigm change from both theoretical and practical perspectives. On the theoretical level, starting with Kuhn and his The Structures of the Scientific Revolution, this study explores the logical essence of the concept of “paradigm”. At the practical level, through various forms such as questionnaires and interviews, the three connotations of scientific research paradigm change in the new era have been condensed. Namely, solving systematic and complex problems has become the main driving force for scientific research paradigm change in the new era, …

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Philosophy Of Meta Publishing And Practice Of Platform Construction Toward Open Science, Jiansheng Qu, Chunjiang Liu, Qianfei Tian, Kemin Huang, Enbo Jiang Jul 2023

Philosophy Of Meta Publishing And Practice Of Platform Construction Toward Open Science, Jiansheng Qu, Chunjiang Liu, Qianfei Tian, Kemin Huang, Enbo Jiang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Based on full investigation of the field of open publishing at home and abroad, this study expounds the role of open science in promoting the evolution of academic exchange system and mechanism, focuses on analyzing and summarizing the historical evolution, development change, and evolution law of academic publishing mode, and puts forward the meta-publishing concept that meets the needs of the open science era, so as to adapt to the development evolution and mode transformation of academic publishing. Based on the concept of “meta-publishing”, the idea of building a meta-publishing platform is proposed to promote the construction of a new …

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Devoting Continuous Efforts To Innovations And Development Of Ruminant Livestock Life-Cycle Nutrition Program, Zhixiong He, Zhaomin Hu, Hongsheng Wang, Jinzhen Jiao, Xuefeng Han, Yong Liu, Shaoxun Tang, Chuanshe Zhou, Min Wang, Zhiliang Tan Jul 2023

Devoting Continuous Efforts To Innovations And Development Of Ruminant Livestock Life-Cycle Nutrition Program, Zhixiong He, Zhaomin Hu, Hongsheng Wang, Jinzhen Jiao, Xuefeng Han, Yong Liu, Shaoxun Tang, Chuanshe Zhou, Min Wang, Zhiliang Tan

Bulletin of Chinese Academy of Sciences (Chinese Version)

Ruminant livestock such as cattle and sheep can provide high-quality beef, mutton and milk, which are high-quality protein sources meeting the increasingly diverse food consumption needs for human being. Developing high-quality herbivorous animal husbandry is a concrete practice of practicing the “Greater Food” approach. The precise supply of forages and concentrates meeting the requirements of all nutrients in the whole life cycle is vital for cost saving and efficiency increasing of ruminant livestock industry, which is an important way to high-quality development. The whole life cycle nutrition is developed on the basis of traditional ruminant nutrition and new technologies made …

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Mechanisms Of Fibrillar Aggregation Of The Lens Small Heat Shock Proteins, Αa- And Αb-Crystallin, Russell James Mcfarland Jul 2023

Mechanisms Of Fibrillar Aggregation Of The Lens Small Heat Shock Proteins, Αa- And Αb-Crystallin, Russell James Mcfarland

Dissertations and Theses

The protein αB-crystallin represents the archetypical small heat-shock protein (sHSP), and together with αA-crystallin makes up the primary chaperone system in the eye lens, where they play a critical role in maintaining proteostasis. To achieve transparency, the lens undergoes a loss of organelles and both protein turnover halts, requiring that proteins remain functional for long periods of time as they accumulate chemical damage. The α-crystallins are highly abundant in the lens to stabilize proteostasis for multiple decades. Over time though, the small heat-shock proteins become overwhelmed by a high burden of destabilized clients and their own accumulated chemical damage. Mechanistic …

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The Card, Vicki Hicks Jul 2023

The Card, Vicki Hicks

Mend

No abstract provided.

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Harmful Health Care, Kwaneta Harris Jul 2023

Harmful Health Care, Kwaneta Harris

Mend

No abstract provided.

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Ontological Constructivism In Higher Education: To Have, To Know, To Be, Richard Dubé Jul 2023

Ontological Constructivism In Higher Education: To Have, To Know, To Be, Richard Dubé

Turning Toward Being: The Journal of Ontological Inquiry in Education

The first objective of this article is to acknowledge the significant contribution of constructivism in its ability to critically challenge what realism often takes for granted as certain or as the truth. The second is to explore how it could go much further, beyond thinking and into being. Having concerned itself mostly with epistemology and the transformation of our ways of thinking, constructivism has come to neglect ontology and the possible transformation of our ways of being. Such an ontological turn is considered important for the reform of higher education.

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The Heart Of The Matter: Icwa And The Future Of Native American Child Welfare, Amelia Tidwell Jul 2023

The Heart Of The Matter: Icwa And The Future Of Native American Child Welfare, Amelia Tidwell

Journal of the National Association of Administrative Law Judiciary

The United States has a long and tragic history of removing Native American children from their homes and culture at shocking rates. Congress passed the Indian Child Welfare Act (ICWA) in 1978 in response to that crisis and many states have bolstered the Act with state legislation and tribal-state agreements, but racial disparities are still present in the child welfare system today. Some states with low Native American populations joined non-Native American prospective adoptive parents in a constitutional challenge of ICWA, and hundreds of supporters (tribes, organizations, and states) poured out support for the Act. The Supreme Court heard the …

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The Immigration Court System: Unconstitutionality At The Hands Of The Executive To Push Nativism, Chloe Wigul Jul 2023

The Immigration Court System: Unconstitutionality At The Hands Of The Executive To Push Nativism, Chloe Wigul

Journal of the National Association of Administrative Law Judiciary

The United States’ immigration court system is located within the U.S. Department of Justice’s Executive Office for Immigration Review and operated under the power of the attorney general. Consequently, the attorney general can review and overrule decisions made by the Board of Immigration Appeals, the immigration appellate body. If the attorney general uses this authority, his decision cannot be reconsidered, and his opinion becomes precedent. Immigration courts are unique in that no other court system is located within or controlled by the executive branch. Focusing on key historical eras, this Comment compares the development of immigration law and policy with …

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All Cases Matter: Mitigating Bias In The Administrative Law Judiciary, Cherron Payne Jul 2023

All Cases Matter: Mitigating Bias In The Administrative Law Judiciary, Cherron Payne

Journal of the National Association of Administrative Law Judiciary

After an introduction and explanation of bias in Part I, Part II of this article explores the issue of bias and the underlying factors that configure bias, such as attitude, stereotype, and prejudice. Part II also examines the two principal types of bias, explicit bias and implicit bias, and defines common subsets of bias, such as gender bias. Part III presents implicit bias as an unconscious, utilitarian, and neuroscientific mechanism. Part III examines the neuroscience of decision-making and the neural structures that influence and regulate decision-making processes. Part III also discusses emotion as an underpinning to decision-making and the role …

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Microglia At Sites Of Atrophy Restrict The Progression Of Retinal Degeneration Via Galectin-3 And Trem2 Interactions, Chen Yu, Eleonora M. Lad, Rose Mathew, Sejiro Littleton, Yun Chen, Kai Schlepckow, Simone Degan, Lindsey Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, A D. Proia, Marco Colonna, Christian Haass, Daniel R. Saban Jul 2023

Microglia At Sites Of Atrophy Restrict The Progression Of Retinal Degeneration Via Galectin-3 And Trem2 Interactions, Chen Yu, Eleonora M. Lad, Rose Mathew, Sejiro Littleton, Yun Chen, Kai Schlepckow, Simone Degan, Lindsey Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, A D. Proia, Marco Colonna, Christian Haass, Daniel R. Saban

Osteopathic Medicine, Jerry M. Wallace School of

Degenerative diseases of the outer retina, including age-related macular degeneration (AMD), are characterized by atrophy of photoreceptors and retinal pigment epithelium (RPE). In these blinding diseases, macrophages are known to accumulate ectopically at sites of atrophy, but their ontogeny and functional specialization within this atrophic niche remain poorly understood, especially in the human context. Here, we uncovered a transcriptionally unique profile of microglia, marked by galectin-3 upregulation, at atrophic sites in mouse models of retinal degeneration and in human AMD. Using disease models, we found that conditional deletion of galectin-3 in microglia led to defects in phagocytosis and consequent augmented …

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Levels Of Persistent Organic Pollutants (Pops) In The Antarctic Atmosphere Over Time (1980 To 2021) And Estimation Of Their Atmospheric Half-Lives, Thais Luarte, Victoria A. Gómez-Aburto, Ignacio Poblete-Castro, Eduardo Castro-Nallar, Nicolas Hunneus, Marco Molina-Montenegro, Claudia Egas, Germán Azcune, Andrés Pérez-Parada, Rainier Lohmann, Pernilla Bohlin-Nizzetto, Jordi Dachs, Susan Bengtson-Nash, Gustavo Chiang, Karla Pozo, Cristóbal J. Galbán-Malagón Jul 2023

Levels Of Persistent Organic Pollutants (Pops) In The Antarctic Atmosphere Over Time (1980 To 2021) And Estimation Of Their Atmospheric Half-Lives, Thais Luarte, Victoria A. Gómez-Aburto, Ignacio Poblete-Castro, Eduardo Castro-Nallar, Nicolas Hunneus, Marco Molina-Montenegro, Claudia Egas, Germán Azcune, Andrés Pérez-Parada, Rainier Lohmann, Pernilla Bohlin-Nizzetto, Jordi Dachs, Susan Bengtson-Nash, Gustavo Chiang, Karla Pozo, Cristóbal J. Galbán-Malagón

Graduate School of Oceanography Faculty Publications

Persistent organic pollutants (POPs) are synthetic compounds that were intentionally produced in large quantities and have been distributed in the global environment, originating a threat due to their persistence, bioaccumulative potential, and toxicity. POPs reach the Antarctic continent through long-range atmospheric transport (LRAT). In these areas, low temperatures play a significant role in the environmental fate of POPs, retaining them for a long time due to cold trapping by diffusion and wet deposition, acting as a net sink for many POPs. However, in the current context of climate change, the remobilization of POPs that were trapped in water, ice, and …

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Crop-Livestock Diversification And Efficiency In Agriculture, Jay Parsons, Maroua Afi Jul 2023

Crop-Livestock Diversification And Efficiency In Agriculture, Jay Parsons, Maroua Afi

Cornhusker Economics

Diversification is a familiar strategy for managing risk in agriculture. It can take several forms including growing more than one crop or operating a farm with both crop and livestock enterprises. As with other strategies for managing risk, diversification comes with a unique set of costs. Managing a farm with multiple enterprises creates additional overhead as well as additional demands on management, labor, land, capital, and other resources. Diversification adds complexity to an operation and too much complexity can lead to inefficiencies.

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Addressing The Ocean-Climate Nexus In The Bbnj Agreement: Strategic Environmental Assessments, Human Rights And Equity In Ocean Science, Elisa Morgera, Kirsty Mcquaid, Giulia La Bianca, Holly Niner, Lynne Shannon, Mia Strand, Sian Rees, Kerry Howell, Bernadette Snow, Alana Malinde Sn Lancaster, Warwick Sauer Jul 2023

Addressing The Ocean-Climate Nexus In The Bbnj Agreement: Strategic Environmental Assessments, Human Rights And Equity In Ocean Science, Elisa Morgera, Kirsty Mcquaid, Giulia La Bianca, Holly Niner, Lynne Shannon, Mia Strand, Sian Rees, Kerry Howell, Bernadette Snow, Alana Malinde Sn Lancaster, Warwick Sauer

School of Biological and Marine Sciences

The Agreement on Marine Biodiversity of Areas beyond National Jurisdiction (BBNJ Agreement) opens a new path in international law towards addressing issues at the ocean-climate nexus, as well as considering implications for the protection of human rights and achieving equity among States in the context of ocean knowledge production and environmental management. Based on an interdisciplinary reflection, the new international obligations on strategic environmental assessments (SEAs), and new institutional arrangements, are identified as crucial avenues to addressing climate change mitigation and ensuring fair research partnerships, mutual capacity-building and technology co-development between the Global North and South. SEAs can also support …

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Field Evidence Of Caddisfly Larvae (Trichoptera: Limnephilidae, Leptoceridae) Using Alien Crassula Helmsii (Kirk) Cockayne Fragments (Saxifragales: Crassulaceae) In Case Construction, Samuel J.L. Tasker, David T. Bilton Jul 2023

Field Evidence Of Caddisfly Larvae (Trichoptera: Limnephilidae, Leptoceridae) Using Alien Crassula Helmsii (Kirk) Cockayne Fragments (Saxifragales: Crassulaceae) In Case Construction, Samuel J.L. Tasker, David T. Bilton

School of Biological and Marine Sciences

We present the first field observations of caddisfly (Trichoptera) larvae using an invasive alien aquatic plant, Crassula helmsii (Kirk) Cockayne, in case construction. In samples from invaded ponds across the UK and Belgium, we have recorded the presence of C. helmsii fragments in cases from Limnephilus lunatus Curtis, Citation1834, Limnephilus marmoratus Curtis, Citation1834, Limnephilus flavicornis (Fabricius, Citation1787) (Limnephilidae), Triaenodes bicolor (Curtis, Citation1834), and Oecetis furva (Rambur, Citation1842) (Leptoceridae). Fragmentation of C. helmsii in case creation and augmentation may produce vegetative propagules, thus facilitating further dispersal of this invasive macrophyte.

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