Digital Commons Network^™

Evaluating The Response Of Chemoradiation Combined With Immunotherapy In Treating Locally Advanced Cervical Cancer, Kala Pham, Kyoko Yoshida-Court, Olsi Gjyshi, Madison P. O'Hara, Tatiana Cisneros Napravnik, Lauren Colbert, Jagannadha Sastry, Ann H. Klopp

Summer Experience 2023

No abstract provided.

Return To Activity Following Acl Reconstruction With The Fertilized Acl: A Retrospective Study., Chad Lavender, Timothy Hewett, John Johnson, Richard Peluso, Tyag Patel, Shane Taylor

Marshall Journal of Medicine

Introduction

The objective of this retrospective study is to evaluate outcomes in patients who underwent the fertilized anterior cruciate ligament (ACL) reconstruction procedure. We aim to investigate the return to previous level of activity, safety, and re-rupture rates of the ACL reconstruction augmented with bone marrow concentrate, demineralized bone matrix, autograft bone, and a suture tape (the fertilized ACL).

Methods

A comprehensive review of medical records was conducted for patients treated with the fertilized ACL (FACL). Medical records of all the patients who underwent reconstruction surgery between July 2018 and January 2021 were evaluated. The inclusion criteria for the study …

Serum Endothelin-1 Level Among Adult Indonesian Females With Obesity: A Nested Cross-Sectional Study From Universitas Gadjah Mada Health And Demographic Surveillance System, Sleman, Indonesia, Anggoro Budi Hartopo, Maria Patricia Inggriani, Jajah Fachiroh, Fatwa Sari Tetra Dewi

Journal of the Hong Kong College of Cardiology

Background The increased obesity prevalence is seen among adult Indonesian females. Obesity is linked to increased endothelin-1 levels, which contribute to endothelial dysfunction, inflammation and insulin resistance. This study aimed to investigate the association between serum endothelin-1 levels with obesity among Indonesian females. Methods This was a cross-sectional study. The subjects were population of Universitas Gadjah Mada Health and Demographic Surveillance System (HDSS) Sleman, Indonesia. We collected venous blood, measured obesity parameters and performed the standardized questionnaire from 124 males and females. Endothelin-1 level was measured from serum by ELISA-methods. Endothelin-1 level was compared between subjects according to obesity category …

Best Practices To Promote Field Science Safety, Kristen Yarincik, Anne Kelly, Terry Mcglynn, Robin M. Verble

Biological Sciences Faculty Research & Creative Works

Interventions are necessary to address the ongoing epidemic of sexual harassment and assault in field settings. An evidence-based approach to identifying specific interventions will be most effective at promoting the safety of scientists. We present the results of a workshop conducted by experts in field biology and the study of sexual harassment and assault that identified a comprehensive set of best practices for individuals and organizations. These recommendations are grounded in peer-reviewed scholarship and are separated into four topics: culture change, accountability, policy development, and reporting. The resulting report of the workshop recommends 44 practices, categorized by the resources required …

Neural Network Learning For Pdes With Oscillatory Solutions And Causal Operators, Lizuo Liu

Mathematics Theses and Dissertations

In this thesis, we focus on developing neural networks algorithms for scientific computing. First, we proposed a phase shift deep neural network (PhaseDNN), which provides a uniform wideband convergence in approximating high frequency functions and solutions of wave equations. Several linearized learning schemes have been proposed for neural networks solving nonlinear Navier-Stokes equations. We also proposed a causality deep neural network (Causality-DeepONet) to learn the causal response of a physical system. An extension of the Causality-DeepONet to time-dependent PDE systems is also proposed. The PhaseDNN makes use of the fact that common DNNs often achieve convergence in the low frequency …

Transition And Transcendence: An Approach To Constructive Transgender Theology With Insights From Elisabeth Schüssler Fiorenza And Karl Rahner, Maggie Nadalin

School of Theology and Seminary Graduate Papers/Theses

Recent attempts at theology impacting transgender individuals from the Catholic bishops in the United States have not only angered and disheartened many but have also failed to address transgender individuals as human persons. Relying on motifs devoid of scientific dialogue, the bishops’ attempts at applying theology to individuals of transgender experience ignores decades of research in both the worlds of the physical and social sciences.

This paper is an attempt to frame the discussion around transgender individuals in a space where theology and science are able to dialogue for their mutual enrichment. Drawing from the experience of the author as …

Suitability And Nutritional Analysis Of Spotted Lanternfly Habitats, Kathryn Hickey

Biology Student Scholarship

The spotted lanternfly is an invasive bug that has recently started taking over the Northeastern US, and has even made it to Rhode Island. Although this species is intriguing with its bright red back and spots, it is hurting native plant species and the agriculture industry by feeding on crops, like grapes and cherries. It uses a tongue-like mouthpart to pierce through the plant and feed directly on the sap inside. This punctures plant stems and causes them to drip sap, wither, and even mold. The lanternfly’s most preferred host plant is the invasive tree-of-heaven, which grows and spreads quickly …

Effect Of Decreased Snowfall During An Atypical Winter On A Rare Butterfly’S Host Plant, Breelyn Gilbert

Biology Student Scholarship

In the Northeastern US, one result of climate change is decreased snowfall and earlier snowmelt. Such changes can alter the relationship between climate and the timing of cyclical biological phenomena— the phenology of organisms. This is especially concerning for species that interact with one another such as butterflies and their host plants. For this study, I focused on the host plant of the rare frosted elfin butterfly. The frosted elfin is a species of concern in RI, MA, and CT, among 8 other states, and they are a host plant specialist only laying eggs on yellow wild indigo (Baptisia …

Tutorial: Using Neuron For Neuromechanical Simulations, Hillel J. Chiel, Peter J. Thomas

Faculty Scholarship

The dynamical properties of the brain and the dynamics of the body strongly influence one another. Their interaction generates complex adaptive behavior. While a wide variety of simulation tools exist for neural dynamics or biomechanics separately, there are few options for integrated brain-body modeling. Here, we provide a tutorial to demonstrate how the widely-used NEURON simulation platform can support integrated neuromechanical modeling. As a first step toward incorporating biomechanics into a NEURON simulation, we provide a framework for integrating inputs from a “periphery” and outputs to that periphery. In other words, “body” dynamics are driven in part by “brain” variables, …

Loss Of Flockmates Weakens Winter Site Fidelity In Golden-Crowned Sparrows (Zonotrichia Atricapilla), Anastasia E. Madsen, Bruce E. Lyon, Alexis S. Chaine, Theadora A. Block, Daizaburo Shizuka

School of Biological Sciences: Faculty Publications

Animal social interactions have an intrinsic spatial basis as many of these interactions occur in spatial proximity. This presents a dilemma when determining causality: Do individuals interact socially because they happen to share space, or do they share space because they are socially linked? We present a method that uses demographic turnover events as a natural experiment to investigate the links between social associations and space use in the context of interannual winter site fidelity in a migratory bird. We previously found that golden-crowned sparrows (Zonotrichia atricapilla) show consistent flocking relationships across years, and that familiarity between individuals …

Transcriptional Regulation Of The Synthesis And Secretion Of Farnesol In The Fungus Candida Albicans: Examination Of The Homann Transcription Regulator Knockout Collection, Daniel Gutzmann, Jaxon J. Kramer, Brigid M. Toomey, Cory Honsinger Thomas Boone, Audrey L. Atkin, Kenneth Nickerson

School of Biological Sciences: Faculty Publications

Candida albicans is an efficient colonizer of human gastrointestinal tracts and skin and is an opportunistic pathogen. C. albicans exhibits morphological plasticity, and the ability to switch between yeast and filamentous morphologies is associated with virulence. One regulator of this switch is the quorum sensing molecule farnesol that is produced by C. albicans throughout growth. However, the synthesis, secretion, regulation, and turnover of farnesol are not fully understood. To address this, we used our improved farnesol assay to screen a transcription regulator knockout library for differences in farnesol accumulation in whole cultures, pellets, and supernatants. All screened mutants produced …

The Misadventures Of Expectations, Laura Elizabeth Solano

Masters Theses

The following research and manuscript discusses the art of using characterization and storytelling to teach younger generations. If used effectively, characterization has the power to transport a reader into the story’s world. The manuscript that follows is the first attempt at a story about friendship, loyalty, and self-actualization. Against all odds, a young man leaves his country to uncover the truth about his family’s demise and reported treason. As he ventures forward, he meets all kinds of people and learns the value of true friendship.

Methods To Study Activity Dependent Protein Synthesis In Autism Spectrum Disorder, Megan Webb, Karin F K Ejendal, Tamara L. Kinzer-Ursem

Discovery Undergraduate Interdisciplinary Research Internship

It is estimated by the World Health Organization that 1 in 100 children have autism spectrum disorder (ASD), a condition characterized by neurological differences that may impact a person’s learning or behavior. Clinically, ASD symptoms are alleviated with behavioral or pharmacological therapies, however, not all patients respond to these interventions. Deep brain stimulation (DBS) is a promising treatment of Parkinson’s disease that could also be effective in treating ASD. SynGAP1 is a protein involved in neuronal action that is crucial for regulating synaptic plasticity. Mutations in the SYNGAP1 gene causing haploinsufficiency can result in the manifestation of ASD symptoms. This …

Phenotypic Analysis, Molecular Characterization, And Antibiogram Of Caries-Causing Bacteria Isolated From Dental Patients, Khushbu Farva, Huma Sattar, Hayat Ullah, Abdur Raziq, Muhammad Danish Mehmood, Afrasiab Khan Tareen, Imrana Niaz Sultan, Quratulaain Zohra, Muhammad Waseem Khan

Biological Engineering Student Research

Dental caries is a biofilm-mediated, sugar-driven, multifactorial, dynamic disease that results in the phasic demineralization and remineralization of dental hard tissues. Despite scientific advances in cariology, dental caries remains a severe global concern. The aim of this study was to determine the optimization of microbial and molecular techniques for the detection of cariogenic pathogens in dental caries patients, the prevalence of cariogenic bacteria on the basis of socioeconomic, climatological, and hygienic factors, and in vitro evaluation of the antimicrobial activity of selected synthetic antibiotics and herbal extracts. In this study, oral samples were collected from 900 patients for bacterial strain …

Climate-Driven Changes In Water Quality By Physiographic Region: A Case Study Of Taos County, New Mexico, Michaela Eamma

Civil and Environmental Engineering Theses and Dissertations

Socioeconomic growth and stability in rural regions of the United States where agriculture is the dominant industry are highly reliant on access to sufficient surface water supplies. The water quantity crisis experienced worldwide in recent years has introduced questions about how to best maintain the quality of our remaining resources. Ensuring adequate access to drinking and irrigation water mandates that we protect existing surface water sources and anticipate future threats to quality. The impact of climate change on surface water quality is not spatially uniform, introducing the need to study the water-atmosphere-land system comprehensively.

This research aims to study the …

An Ecological Survey Of East Texas Salamanders Across The Camp Tyler Outdoor Field School In Smith County, Texas, Justin C. Hunt

Biology Theses

Amphibians are a unique class of organisms with a very long and storied evolutionary history of survival. Many modern amphibian clades occupy several vital ecological roles within their native freshwater environments. One of these roles, typically includes functioning as an ecological indicator species, whereby the presence of stable and diverse populations of many amphibian species, including salamanders, within a freshwater ecosystem have long been considered ecological indicators of good habitat quality and stable ecosystem health. Similarly, salamanders also function as important members of their local food webs and act as valuable mediators of complex trophic hierarchies to facilitate nutrient cycling …

Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 84 – Mandan Park Play Area, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

High Fructose Corn Syrup And Sugar Substitutes: Hemoglobin A1c Implications In Diabetes?, Rachelle S. Glover

Doctoral Dissertations and Projects

Diabetes mellitus type 2 (DMt2) is an increasing health concern of epidemic proportion in the United States. High fructose corn syrup (HFCS) and artificial sweeteners (AS) have been implicated as contributory factors to DMt2. This project seeks to demonstrate elimination of daily consumption of HFCS and AS in DMt2 patients can contribute to lower hemoglobin A1C (HgbA1C) levels by comparing two groups of patients receiving two differing diabetes education programs. A reduction of HgbA1C levels by 0.2-0.5% is expected in DMt2 patients instructed to eliminate HFCS and AS, and no change is expected in HgbA1C levels in DMt2 patients receiving …

Multicultural Worship Studies Of Military Chapels In South Korea, Abbey Nicole Bradley

Doctoral Dissertations and Projects

Despite a large body of literature on Korean/American worship, there is little to no research that addresses multicultural worship of the United States Army Garrison (USAG) in the Republic of Korea (ROK) at the Protestant military chapels. In addition, there is also a lack of research regarding worship ministry at USAG installations in general, aside from general multicultural worship models. Developing a biblical and multicultural worship model for the Protestant USAG chapels in the Republic of Korea is essential because of the diverse ethnicities in the U.S. military and the diverse backgrounds, denominations, and cultures within the military chapel communities. …

The Effect Of Fifty Percent Minimum Grades On Student Achievement, James M. Mariani

Doctoral Dissertations and Projects

This causal-comparative quantitative research study aims to determine whether mandating a 50% minimum grade significantly increases student achievement. The setting for this study was one suburban Pennsylvanian high school of approximately 1,250 students. The educational process involves three integrated components: curriculum, instruction, and assessment. Evaluating methods in which schools assign grades is an inherent part of every school assessment system. The Treedale School District and Pennsylvania Department of Education collected data, which the researcher analyzed by performing multiple Mann-Whitney U tests between pre-policy 0%-100% and post policy 50%-100% grade scale groups. The independent variable is grading scale and the dependent …

Intergenerational Model Of Discipleship, David Lyn Sampson

Doctoral Dissertations and Projects

Some of God’s most prominent spiritual leaders are characterized by their deep intergenerational connections. People like Moses and Joshua, Elijah and Elisha, Paul and Timothy, and Jesus and John exemplify it. In this study, “intergenerational” means creating opportunities for intentional dialogue and interaction cross-generationally to foster mentoring and biblical discipleship. This research aims to create an intergenerational model of ministry that will encourage churches to embrace intergenerational discipleship concepts. It is not uncommon for church ministry to seem like silos, with people compartmentalized according to age or phases of life. Silo ministry can hinder individuals from forming generational relationships. Unfortunately, …

The Use Of Multidisciplinary Care Teams In Diagnosing And Managing Care Of Cancer Patients In Eastern Kentucky, Terry Lee Adams

Doctoral Dissertations and Projects

The purpose of this casual comparative quantitative study addressed the lack of individual-level data on the effectiveness of multidisciplinary care teams for cancer patients in rural hospitals. The research questions sought to evaluate the strengths and weaknesses of multidisciplinary care teams for cancer patients in rural hospitals and the roadblocks for successful implementation. The study utilized the pragmatism paradigm to focus on the problem rather than the view of reality. This study was conducted with a fixed design using quantitative methods, specifically, casual comparative. This research worked within the framework of a well-established theory prevalent in the pertinent literature: Social …

Resetting Foundations. Congregational Training For The Small Group Ministry: An Action Research To Correct Intent, Cultivate Community, And Grow Spiritually, Jarrett Gallardo

Doctoral Dissertations and Projects

Small group ministry is crucial for the health and well-being of the church. The problem this DMIN action research sought to address was that Valley Gate Church did not grasp the purpose of small group ministry due to not implementing small groups with well-defined intent. Valley Gate Church is a church plant that launched in 2016. This DMIN action research aimed to create and implement a six-week congregational training to develop small group leaders and members at Valley Gate Church. Twenty-two participants were involved in the entire six-week training. All participants took a pre- and post-training assessment consisting of surveys, …

Whether Covid-19 Infection Affects Human Cognitive Function, June Li Alsgaard

Doctoral Dissertations and Projects

The COVID-19 pandemic, resulting from the SARS-CoV-2 virus, continues to impact the daily lives of individuals worldwide. Although research has been conducted on long-COVID symptoms, the underlying causes remain unclear. Notably, instances of neurological decline have been observed following SARS-CoV-2 infections. 125,573 articles regarding neurological damage and cognitive disfunction were published and can be found from major research databases. For this scholarly project, 25 peer-reviewed journal articles pertaining to long-COVID and neurologic function changes, as well as potential underlying reasons for these changes, were curated. The proposed hypotheses include the virus' ability to pass through and harm the blood-brain barrier …

Sars-Cov-2 Uses Cd4 To Infect T Helper Lymphocytes, Natalia S Brunetti, Louis-Marie Bloyet, Spencer Stumpf, Marjorie C Pontelli, Sean Whelan, Alessandro S Farias, Et Al.

2020-Current year OA Pubs

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such as lymphocytopenia and cytokine storm, which are associated with the severity of the disease and predict mortality. The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-CoV-2 infects human CD4

Design Of A Current Mode Circuit For Zeroth-Order Optimization Of Memristor-Based Neuromorphic Systems, Shery George Mathews

Theses

Artificial neural networks (ANNs) have become widely used over the past decade due to their excellent performance in applications such as object recognition and classification, time series forecasting, machine translation, and more. Key factors contributing to the success of ANNs in these domains include the availability of large datasets and constant improvements in powerful parallel processing architectures such as graphics processing units (GPUs). However, modern ANN models' growing size and complexity preclude their deployment on resource-constrained hardware for edge applications. Neuromorphic computing seeks to address this challenge by using brain-inspired principles to co-design the ANN hardware and algorithms for improved …

The Borgia Reexamined: A New Look At The Borgia Family And The Influence Of Adoptions Within The Family, Nicholas Ryan Mason

Masters Theses

The Borgia’s were a powerful family that garnered a great deal of their influence through the Catholic Church during the late fifteenth and early sixteenth centuries. The height of the Borgia was between 1492 and 1503, when Rodrigo Borgia was elected Pope Alexander VI. Throughout history they have been known for the rumors of murder, incest, greed, and corruption that have surrounded the family ever since they first came to power. An examination of the family may not only lead to a different perspective of the family but may also lead to a deeper understanding of how one's enemies may …

Monitoring The Effects Of Poultry Waste On Fishes And Macroinvertebrates In The Sabine River, Karley R. Parker

Biology Theses

Freshwater is a vital resource that provides life and sustainability for almost all organisms on Earth. It is important to maintain its health and protect it from emerging pollutants that pose a threat to the organisms that use it. Pollution continues to threaten the well-being of the environment’s freshwater sources all around the world that could lead to damaging effects in the future. The Sabine River is a major freshwater resource in the east Texas and western Louisiana areas that provides a habitat for thousands of organisms as well as other domestic uses for humans. In 2019, a waste discharge …

The Effect Of Integrated Pest Management On Honey Bee Behavior And Colony Level Health, Kaitlyn Bresnahan

Biology Student Scholarship

Honey bees are the world’s most commercially valuable pollinators, and they face many threats. The greatest challenge facing honey bees is Varroa mites, which are parasitic mites that feed on bees’ fat bodies, killing bees and spreading diseases. While chemical treatments are available to stop the spread of mites, these treatments are insecticides, which are not ideal to put in a hive of insects. A popular organic method of mite management is using drone comb. Drone brood is preferentially chosen by mites for ovipositing and development because of its larger size and longer development time, so removing drone brood can …

Diversity Of Bees In Trees And Their Foraging Preferences On An Urban College Campus, Aidan Castricone

Biology Student Scholarship

Pollinators collect nutrients from blooming flowers; pollen provides proteins and fats, nectar provides carbohydrates. The few plants that bloom during early Spring are trees such as crabapple (Malus sp). Current research however, mainly focuses on pollinators that forage on the ground and overlooks pollinators foraging in the canopy of trees. Past research showed increased generalization of pollen foraging in bees as seasons move from spring to summer. Here I identified which bee species forage in the canopy on Providence College campus and will analyze the pollen collected using microscopy. This data can inform more specific research on diet breadth, …