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2023

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Self-Harm: Warning Signs, Risk Factors, And Prevention, Alina M. Baltazar Jan 2023

Self-Harm: Warning Signs, Risk Factors, And Prevention, Alina M. Baltazar

Faculty Publications

Rates of suicide and self-harm have been increasing in children and adolescents over the last 20 years (CDC, 2022). Suicidality and self-harm are preventable, treatable, and manageable. Parents and those who work with children, teens, and young adults are an important part in addressing this issue. This article reviews the current statistics of suicide and self-harm, role of trauma, risk-factors, causes, prevention, and treatment options. Practical tips and resources are included. The reader will better understand the phenomenon and know how self-harm and suicide can be prevented and treated.

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Living Out The Principles Of The Ten Commandments, Trevor O'Reggio Jan 2023

Living Out The Principles Of The Ten Commandments, Trevor O'Reggio

Faculty Publications

No abstract provided.

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James White Library Celebrates Its 85th Anniversary, Margaret Adeogun Jan 2023

James White Library Celebrates Its 85th Anniversary, Margaret Adeogun

Faculty Publications

No abstract provided.

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Modern Applicability Of The Book Of Leviticus For Joyful Obedience, Roy Gane Jan 2023

Modern Applicability Of The Book Of Leviticus For Joyful Obedience, Roy Gane

Faculty Publications

No abstract provided.

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The Mediating Effect Of The Covid-19 Pandemic On The Relationship Between Technology And Organizational Performance: Evidence From Ghana Banking Industry, Manaseh Tsekpo, Williams Kwasi Peprah Jan 2023

The Mediating Effect Of The Covid-19 Pandemic On The Relationship Between Technology And Organizational Performance: Evidence From Ghana Banking Industry, Manaseh Tsekpo, Williams Kwasi Peprah

Faculty Publications

This study aimed to investigate the mediating effect of the COVID-19 pandemic on the relationship between technology and organizational performance, using evidence from the Ghana banking industry. The study adopted a correlation and mediation research design, with 232 respondents conveniently sampled from eight indigenous Ghanaian Banks. The data were analyzed using correlation, regression, and mediation techniques. The results show that technology serves as a catalyst for improving organizational performance and alleviating the negative effects of COVID-19 on organizational performance. The findings also revealed that the COVID-19 pandemic highly mediates technology and organizational performance with a significant positive relationship between technology …

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An Organotypic Oral Mucosal Infection Model To Study Host-Pathogen Interactions, Samantha J. Gould, Andrew D. Foey, Vehid M. Salih Jan 2023

An Organotypic Oral Mucosal Infection Model To Study Host-Pathogen Interactions, Samantha J. Gould, Andrew D. Foey, Vehid M. Salih

School of Biomedical Sciences

Early in vitro oral mucosal infection models (OMMs) failed to consider the suitability of the model environment to represent the host immune response. Denture stomatitis (DS) is mediated by Candida albicans, but the role of Staphylococcus aureus remains uncertain. A collagen hydrogel-based OMM containing HaCaT and HGF cell types was developed, characterised and employed to study of tissue invasion and pro-inflammatory cytokine production in response to pathogens. Models formed a robust epithelium. Despite their inflammatory baseline, 24-h infection with C. albicans, and/or S. aureus led to tissue invasion, and significantly upregulated IL-6 and IL-8 production by OMMs when compared to …

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The Relationships Between Supervisor-Subordinate Guanxi, Perceived Supervisor Autonomy Support, Autonomous Motivation, And Employee Job Satisfaction: Evidence From International Hotel Chains In China, Jinhua Zhang, Rong Huang, Qian Chen, Guoqing Zhao Jan 2023

The Relationships Between Supervisor-Subordinate Guanxi, Perceived Supervisor Autonomy Support, Autonomous Motivation, And Employee Job Satisfaction: Evidence From International Hotel Chains In China, Jinhua Zhang, Rong Huang, Qian Chen, Guoqing Zhao

Plymouth Business School

This research aims to assess the structural relationships between supervisor-subordinate guanxi, perceived supervisor autonomy support, autonomous motivation, and employee job satisfaction at international hotel chains’ operations in China. The theoretical model was developed and tested by an online questionnaire method. This study administered an online survey to employees working at international hotel chains in China, and a total of 328 valid responses were used for data analysis which was completed through SPSS Statistics 24.0 and SmartPLS 3.3.3. The results reveal that: there is a significant relationship between autonomous motivation and employee job satisfaction; perceived supervisor autonomy support exerts a significant …

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What’S Really Down The Hospital Plughole?, J. Butler, M. Upton Jan 2023

What’S Really Down The Hospital Plughole?, J. Butler, M. Upton

School of Biomedical Sciences

As reported in recent articles in this journal and others, hospital wastewater plumbing systems (WPS) are increasingly being highlighted as an important source of nosocomial infections [ [1] , [2] ]. Potential interventions to mitigate these risks include changes in patient management through to engineering solutions and modifications to plumbing infrastructure, with recent calls to improve building guidance to mitigate the impact of suboptimal designs on patients and healthcare staff [ [3] ]. The WPS is a complex interlinked system of pipework that is intermittently filled with water containing a multitude of solutes and solids. The interface between this system …

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Air Quality And Mental Health: Evidence, Challenges And Future Directions, Kamaldeep Bhui, Joanne B. Newbury, Rachel M. Latham, Marcella Ucci, Zaheer A. Nasir, Briony Turner, Catherine O'Leary, Helen L. Fisher, Emma Marczylo, Philippa Douglas, Stephen Stansfeld, Simon K. Jackson, Sean Tyrrel, Andrey Rzhetsky, Rob Kinnersley, Prashant Kumar, Caroline Duchaine, Frederic Coulon Jan 2023

Air Quality And Mental Health: Evidence, Challenges And Future Directions, Kamaldeep Bhui, Joanne B. Newbury, Rachel M. Latham, Marcella Ucci, Zaheer A. Nasir, Briony Turner, Catherine O'Leary, Helen L. Fisher, Emma Marczylo, Philippa Douglas, Stephen Stansfeld, Simon K. Jackson, Sean Tyrrel, Andrey Rzhetsky, Rob Kinnersley, Prashant Kumar, Caroline Duchaine, Frederic Coulon

School of Biomedical Sciences

Background Poor air quality is associated with poor health. Little attention is given to the complex array of environmental exposures and air pollutants that affect mental health during the life course. Aims We gather interdisciplinary expertise and knowledge across the air pollution and mental health fields. We seek to propose future research priorities and how to address them. Method Through a rapid narrative review, we summarise the key scientific findings, knowledge gaps and methodological challenges. Results There is emerging evidence of associations between poor air quality, both indoors and outdoors, and poor mental health more generally, as well as specific …

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Perceived Value Within An International Hospitality Learning Environment: Antecedents And Outcomes, Abdallah Elshaer, Rong Huang Jan 2023

Perceived Value Within An International Hospitality Learning Environment: Antecedents And Outcomes, Abdallah Elshaer, Rong Huang

Plymouth Business School

The number of students attending British universities is rapidly increasing, among them, many are international students. These diverse students pose opportunities and concerns regarding the equitable and efficient delivery of the learning environment. This study examines the perceived value within an international learning environment (ILE) and examines antecedents and outcomes of such value in addressing the students' needs. Structure Equation Modeling (PLS-SEM) was used to analyse 323 online survey responses, and thematic analysis and content analysis were used to examine 35 semi-structured interviews. Work-Integrated Learning, Academic Integration, and Scholarship of Teaching and Learning are established as major value practices that …

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Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement In Dialysis-Dependent Patients: A Meta-Analysis, Samuel Burton, Alexander Reynolds, Nicola King, Amit Modi, Sanjay Asopa Jan 2023

Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement In Dialysis-Dependent Patients: A Meta-Analysis, Samuel Burton, Alexander Reynolds, Nicola King, Amit Modi, Sanjay Asopa

School of Biomedical Sciences

Objectives This meta-analysis aims to compare the clinical outcomes of transcatheter aortic valve implantation (TAVI) versus aortic valve replacement (AVR) for aortic stenosis in dialysis-dependent patients. Methods Literature searches employed PubMed, Web of Science, Google Scholar and Embase to identify relevant studies. Bias-treated data were prioritized, isolated and pooled for analysis; raw data were utilized where bias-treated data were unavailable. Outcomes were analysed to assess for study data crossover. Results Literature search identified 10 retrospective studies; following data source analysis, five studies were included. Upon pooling of bias-treated data, TAVI was significantly favoured in early mortality [odds ratio (OR), 0.42; …

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Evaluation Of A Complex Intervention For Prisoners With Common Mental Health Problems, Near To And After Release: The Engager Randomised Controlled Trial, Richard Byng, Tim Kirkpatrick, Charlotte Lennox, Fiona C. Warren, Rob Anderson, Sarah Louise Brand, Lynne Callaghan, Lauren Carroll, Graham Durcan, Laura Gill, Sara Goodier, Jonathan Graham, Rebecca Greer, Mark Haddad, Tirril Harris, William Henley, Rachael Hunter, Sarah Leonard, Mike Maguire, Susan Michie, Christabel Owens, Mark Pearson, Cath Quinn, Sarah Rybczynska-Bunt, Caroline Stevenson, Amy Stewart, Alex Stirzaker, Roxanne Todd, Florian Walter, Lauren Weston, Nat Wright, Rod S. Taylor, Jenny Shaw Jan 2023

Evaluation Of A Complex Intervention For Prisoners With Common Mental Health Problems, Near To And After Release: The Engager Randomised Controlled Trial, Richard Byng, Tim Kirkpatrick, Charlotte Lennox, Fiona C. Warren, Rob Anderson, Sarah Louise Brand, Lynne Callaghan, Lauren Carroll, Graham Durcan, Laura Gill, Sara Goodier, Jonathan Graham, Rebecca Greer, Mark Haddad, Tirril Harris, William Henley, Rachael Hunter, Sarah Leonard, Mike Maguire, Susan Michie, Christabel Owens, Mark Pearson, Cath Quinn, Sarah Rybczynska-Bunt, Caroline Stevenson, Amy Stewart, Alex Stirzaker, Roxanne Todd, Florian Walter, Lauren Weston, Nat Wright, Rod S. Taylor, Jenny Shaw

Peninsula Medical School

Background Many male prisoners have significant mental health problems, including anxiety and depression. High proportions struggle with homelessness and substance misuse. Aims This study aims to evaluate whether the Engager intervention improves mental health outcomes following release. Method The design is a parallel randomised superiority trial that was conducted in the North West and South West of England (ISRCTN11707331). Men serving a prison sentence of 2 years or less were individually allocated 1:1 to either the intervention (Engager plus usual care) or usual care alone. Engager included psychological and practical support in prison, on release and for 3–5 months in …

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Impact Of Digital Technologies On Self-Efficacy In People With Parkinson’S: A Scoping Review Protocol, Andrew Michael Hall, Sree Aroori, Camille B. Carroll, Edward Meinert, Victoria Allgar Jan 2023

Impact Of Digital Technologies On Self-Efficacy In People With Parkinson’S: A Scoping Review Protocol, Andrew Michael Hall, Sree Aroori, Camille B. Carroll, Edward Meinert, Victoria Allgar

Peninsula Medical School

Introduction Parkinson’s disease (PD) is the second most common neurological disease globally, for which currently no one definitive cause or cure exists. Estimates suggest that 145 000 people with Parkinson’s (PwP) live in the UK. PD presents with motor and non-motor symptoms fluctuating significantly in and between individuals continually throughout the day. PD adversely affects activities of daily living, quality of life and well-being. Self-efficacy is an important belief to improve for PwP as it enables the individual to develop confidence in their ability to exert control over their own motivation, behaviour and social environment. This scoping review aims to …

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Adding Web-Based Support To Exercise Referral Schemes Improves Symptoms Of Depression In People With Elevated Depressive Symptoms: A Secondary Analysis Of The E-Coacher Randomised Controlled Trial, Jeffrey Lambert, Adrian Taylor, Adam Streeter, Colin Greaves, Wendy M. Ingram, Sarah Dean, Kate Jolly, Nanette Mutrie, Lisa Price, John Campbell Jan 2023

Adding Web-Based Support To Exercise Referral Schemes Improves Symptoms Of Depression In People With Elevated Depressive Symptoms: A Secondary Analysis Of The E-Coacher Randomised Controlled Trial, Jeffrey Lambert, Adrian Taylor, Adam Streeter, Colin Greaves, Wendy M. Ingram, Sarah Dean, Kate Jolly, Nanette Mutrie, Lisa Price, John Campbell

Peninsula Medical School

Background: Exercise referral schemes (ERS) reduce depression but the additional effect on mental health from web-based behavioural support is unknown. The e-coachER trial reported no effect of augmenting usual ERS with theory-driven web-based behavioural support on moderate to vigorous physical activity (MVPA) at 12 months for patients with chronic physical and mental health conditions. The present study reports the effects of the e-coachER intervention on depression, anxiety and MVPA only among participants with elevated depressive symptoms and investigates whether these were mediated by changes in MVPA and hypothesised cognitive and behavioural processes. Methods: Of the original 450 adults recruited into …

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Quality Standards For The Management Of Alcohol-Related Liver Disease: Consensus Recommendations From The British Association For The Study Of The Liver And British Society Of Gastroenterology Arld Special Interest Group, Richard Parker, Michael Allison, Seonaid Anderson, Richard Aspinall, Sara Bardell, Vikram Bains, Ryan Buchanan, Lynsey Corless, Ian Davidson, Pauline Dundas, Jeff Fernandez, Ewan Forrest, Erica Forster, Dennis Freshwater, Ruth Gailer, Robert Goldin, Vanessa Hebditch, Steve Hood, Arron Jones, Victoria Lavers, Deborah Lindsay, James Maurice, Joanne Mcdonagh, Sarah Morgan, Tania Nurun, Christopher Oldroyd, Elizabeth Oxley, Sally Pannifex, Graham Parsons, Thomas Phillips, Nicole Rainford, Neil Rajoriya, Paul Richardson, J. Ryan, Joanne Sayer, Mandy Smith, Ankur Srivastava, Emma Stennett, Jennifer Towey, Roya Vaziri, Ian Webzell, Andrew Wellstead, Ashwin Dhanda, Steven Masson Jan 2023

Quality Standards For The Management Of Alcohol-Related Liver Disease: Consensus Recommendations From The British Association For The Study Of The Liver And British Society Of Gastroenterology Arld Special Interest Group, Richard Parker, Michael Allison, Seonaid Anderson, Richard Aspinall, Sara Bardell, Vikram Bains, Ryan Buchanan, Lynsey Corless, Ian Davidson, Pauline Dundas, Jeff Fernandez, Ewan Forrest, Erica Forster, Dennis Freshwater, Ruth Gailer, Robert Goldin, Vanessa Hebditch, Steve Hood, Arron Jones, Victoria Lavers, Deborah Lindsay, James Maurice, Joanne Mcdonagh, Sarah Morgan, Tania Nurun, Christopher Oldroyd, Elizabeth Oxley, Sally Pannifex, Graham Parsons, Thomas Phillips, Nicole Rainford, Neil Rajoriya, Paul Richardson, J. Ryan, Joanne Sayer, Mandy Smith, Ankur Srivastava, Emma Stennett, Jennifer Towey, Roya Vaziri, Ian Webzell, Andrew Wellstead, Ashwin Dhanda, Steven Masson

Peninsula Medical School

Objective Alcohol-related liver disease (ALD) is the most common cause of liver-related ill health and liver-related deaths in the UK, and deaths from ALD have doubled in the last decade. The management of ALD requires treatment of both liver disease and alcohol use; this necessitates effective and constructive multidisciplinary working. To support this, we have developed quality standard recommendations for the management of ALD, based on evidence and consensus expert opinion, with the aim of improving patient care. Design A multidisciplinary group of experts from the British Association for the Study of the Liver and British Society of Gastroenterology ALD …

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Motivational Support Intervention To Reduce Smoking And Increase Physical Activity In Smokers Not Ready To Quit: The Tars Rct, Adrian H. Taylor, Tom P. Thompson, Adam Streeter, Jade Chynoweth, Tristan Snowsill, Wendy Ingram, Michael Ussher, Paul Aveyard, Rachael L. Murray, Tess Harris, Colin Green, Jane Horrell, Lynne Callaghan, Colin J. Greaves, Lisa Price, Lucy Cartwright, Jonny Wilks, S Campbell, Dan Preece, Siobhan Creanor Jan 2023

Motivational Support Intervention To Reduce Smoking And Increase Physical Activity In Smokers Not Ready To Quit: The Tars Rct, Adrian H. Taylor, Tom P. Thompson, Adam Streeter, Jade Chynoweth, Tristan Snowsill, Wendy Ingram, Michael Ussher, Paul Aveyard, Rachael L. Murray, Tess Harris, Colin Green, Jane Horrell, Lynne Callaghan, Colin J. Greaves, Lisa Price, Lucy Cartwright, Jonny Wilks, S Campbell, Dan Preece, Siobhan Creanor

Peninsula Medical School

No abstract provided.

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Comprehensive Measurement Of The Prevalence Of Dementia In Low- And Middle-Income Countries: Stride Methodology And Its Application In Indonesia And South Africa, Nicolas Farina, Roxanne Jacobs, Yuda Turana, Fasihah Irfani Fitri, Marguerite Schneider, Imelda Theresia, Sumaiyah Docrat, Tara Puspitarini Sani, Lydia Augustina, Emiliano Albanese, Adelina Comas-Herrera, Toit P Du, Cleusa P. Ferri, Ishtar Govia, Aliaa Ibnidris, Martin Knapp, Sube Banerjee Jan 2023

Comprehensive Measurement Of The Prevalence Of Dementia In Low- And Middle-Income Countries: Stride Methodology And Its Application In Indonesia And South Africa, Nicolas Farina, Roxanne Jacobs, Yuda Turana, Fasihah Irfani Fitri, Marguerite Schneider, Imelda Theresia, Sumaiyah Docrat, Tara Puspitarini Sani, Lydia Augustina, Emiliano Albanese, Adelina Comas-Herrera, Toit P Du, Cleusa P. Ferri, Ishtar Govia, Aliaa Ibnidris, Martin Knapp, Sube Banerjee

Peninsula Medical School

Background A core element of the Strengthening Responses to Dementia in Developing Countries (STRiDE) programme was to generate novel data on the prevalence, cost and impact of dementia in low- and middle-income countries, to build better health policy. Indonesia and South Africa are two middle-income countries in need of such data. Aims To present the STRiDE methodology and generate estimates of dementia prevalence in Indonesia and South Africa. Method We conducted community-based, single-phase, cross-sectional studies in Indonesia and South Africa, randomly sampling participants aged 65 years or older in each country. Dementia prevalence rates for each country were generated by …

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A Pragmatic, Multicentre, Double-Blind, Placebo-Controlled Randomised Trial To Assess The Safety, Clinical And Cost-Effectiveness Of Mirtazapine And Carbamazepine In People With Alzheimer’S Disease And Agitated Behaviours: The Hta-Symbad Trial, Sube Banerjee, Nicolas Farina, Catherine Henderson, Juliet High, Susan Stirling, Lee Shepstone, Julia Fountain, Clive Ballard, Peter Bentham, Alistair Burns, Chris Fox, Paul Francis, Robert Howard, Martin Knapp, Iracema Leroi, Gill Livingston, Ramin Nilforooshan, Shirley Nurock, John O’Brien, Annabel Price, Alan J. Thomas, Ann Marie Swart, Tanya Telling, Naji Tabet Jan 2023

A Pragmatic, Multicentre, Double-Blind, Placebo-Controlled Randomised Trial To Assess The Safety, Clinical And Cost-Effectiveness Of Mirtazapine And Carbamazepine In People With Alzheimer’S Disease And Agitated Behaviours: The Hta-Symbad Trial, Sube Banerjee, Nicolas Farina, Catherine Henderson, Juliet High, Susan Stirling, Lee Shepstone, Julia Fountain, Clive Ballard, Peter Bentham, Alistair Burns, Chris Fox, Paul Francis, Robert Howard, Martin Knapp, Iracema Leroi, Gill Livingston, Ramin Nilforooshan, Shirley Nurock, John O’Brien, Annabel Price, Alan J. Thomas, Ann Marie Swart, Tanya Telling, Naji Tabet

Peninsula Medical School

No abstract provided.

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Guiding Principles For Effective Collaborative Implementation Strategies For Multisite Hospital Improvement Initiatives: A Mixed-Method Realist Evaluation Of Collaborative Strategies Used In Four Multisite Initiatives At Public Hospitals In New South Wales, Australia, Janet C. Long, Mitchell N. Sarkies, Emilie Francis-Auton, Natalie Roberts, Rebecca Hardwick, Hoa Mi Nguyen, Jean Frederic Levesque, Diane E. Watson, Johanna Westbrook, Peter D. Hibbert, Frances Rapport, Jeffrey Braithwaite Jan 2023

Guiding Principles For Effective Collaborative Implementation Strategies For Multisite Hospital Improvement Initiatives: A Mixed-Method Realist Evaluation Of Collaborative Strategies Used In Four Multisite Initiatives At Public Hospitals In New South Wales, Australia, Janet C. Long, Mitchell N. Sarkies, Emilie Francis-Auton, Natalie Roberts, Rebecca Hardwick, Hoa Mi Nguyen, Jean Frederic Levesque, Diane E. Watson, Johanna Westbrook, Peter D. Hibbert, Frances Rapport, Jeffrey Braithwaite

Peninsula Medical School

Objective Large-scale, multisite hospital improvement initiatives can advance high-quality care for patients. Implementation support is key to adoption of change in this context. Strategies that foster collaboration within local teams, across sites and between initiative developers and users are important. However not all implementation strategies are successful in all settings, sometimes realising poor or unintended outcomes. Our objective here is to develop guiding principles for effective collaborative implementation strategies for multi-site hospital initiatives. Design Mixed-method realist evaluation. Realist studies aim to examine the underlying theories that explain differing outcomes, identifying mechanisms and contextual factors that may trigger them. Setting We …

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Recommendations From Diabetes Uk's 2022 Diabetes And Physical Activity Workshop, Anna Morris, Chris Bright, Matthew Cocks, Neil Gibson, Louise Goff, Colin Greaves, Simon Griffin, Ben Jane, Florence Kinnafick, Paul Robb, Michelle Roberts, David Salman, John Saxton, Adrian Taylor, Daniel West, Thomas Yates, Rob C. Andrews, Jason M.R. Gill Jan 2023

Recommendations From Diabetes Uk's 2022 Diabetes And Physical Activity Workshop, Anna Morris, Chris Bright, Matthew Cocks, Neil Gibson, Louise Goff, Colin Greaves, Simon Griffin, Ben Jane, Florence Kinnafick, Paul Robb, Michelle Roberts, David Salman, John Saxton, Adrian Taylor, Daniel West, Thomas Yates, Rob C. Andrews, Jason M.R. Gill

Peninsula Medical School

Abstract Aims To describe the process and outputs of a workshop convened to identify key priorities for future research in the area of diabetes and physical activity and provide recommendations to researchers and research funders on how best to address them. Methods A 1‐day research workshop was conducted, bringing together researchers, people living with diabetes, healthcare professionals, and members of staff from Diabetes UK to identify and prioritise recommendations for future research into physical activity and diabetes. Results Workshop attendees prioritised four key themes for further research: (i) better understanding of the physiology of exercise in all groups of people: …

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Oral Microbes And The Formation Of Cerebral Abscesses: A Single-Centre Retrospective Study, Raul Bescos, Holly Roy, Ewen Mccoll, Umar Rehman, Elizabeth Cray, Louise A. Belfield, King David Nweze, Kevin Tsang, William Singleton, Peter Whitfield, Zoe Brookes Jan 2023

Oral Microbes And The Formation Of Cerebral Abscesses: A Single-Centre Retrospective Study, Raul Bescos, Holly Roy, Ewen Mccoll, Umar Rehman, Elizabeth Cray, Louise A. Belfield, King David Nweze, Kevin Tsang, William Singleton, Peter Whitfield, Zoe Brookes

Peninsula Medical School

Objective: Intracranial abscesses are relatively uncommon, but can result in significant mortality and morbidity. Whilst many potential causes of brain abscesses are recognised, in many cases the origin of infection remains clinically unidentified. Our objective was to investigate the role of bacteria found in the oral cavity in the development of brain abscesses. Methods: A retrospective analysis was performed using data from 87 patients admitted to a single UK neurosurgical unit with brain abscesses over a 16-year period. Using microbiological data obtained from abscess sampling and peripheral cultures, species of bacteria were categorised in patients where no primary source of …

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Covid-19 Vaccine Effectiveness Against Hospitalisation And Death Of People In Clinical Risk Groups During The Delta Variant Period: English Primary Care Network Cohort Study, Heather J. Whitaker, Ruby S.M. Tsang, Rachel Byford, Carole Aspden, Elizabeth Button, Praveen Sebastian Pillai, Gavin Jamie, Debasish Kar, John Williams, Mary Sinnathamby, Gemma Marsden, William H. Elson, Meredith Leston, Sneha Anand, Cecilia Okusi, Xuejuan Fan, Ezra Linley, Cathy Rowe, Silvia Darcangelo, Ashley D. Otter, Joanna Ellis, F.D. Richard Hobbs, Victoria Tzortziou-Brown, Maria Zambon, Mary Ramsay, Kevin E. Brown, Gayatri Amirthalingam, Nick J. Andrews, Simon De Lusignan, Jamie Lopez Bernal Jan 2023

Covid-19 Vaccine Effectiveness Against Hospitalisation And Death Of People In Clinical Risk Groups During The Delta Variant Period: English Primary Care Network Cohort Study, Heather J. Whitaker, Ruby S.M. Tsang, Rachel Byford, Carole Aspden, Elizabeth Button, Praveen Sebastian Pillai, Gavin Jamie, Debasish Kar, John Williams, Mary Sinnathamby, Gemma Marsden, William H. Elson, Meredith Leston, Sneha Anand, Cecilia Okusi, Xuejuan Fan, Ezra Linley, Cathy Rowe, Silvia Darcangelo, Ashley D. Otter, Joanna Ellis, F.D. Richard Hobbs, Victoria Tzortziou-Brown, Maria Zambon, Mary Ramsay, Kevin E. Brown, Gayatri Amirthalingam, Nick J. Andrews, Simon De Lusignan, Jamie Lopez Bernal

Peninsula Medical School

No abstract provided.

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Awareness Of Social Care Needs In People With Epilepsy And Intellectual Disability, A. Gabrielsson, S. Tromans, H. Newman, P. Triantafyllopoulou, A. Hassiotis, P. Bassett, L. Watkins, I. Sawhney, M. Cooper, L. Griffiths, A. Pullen, A. Roy, H. Angus-Leppan, Rh Thomas, M. Kinney, P. Tittensor, R. Shankar Jan 2023

Awareness Of Social Care Needs In People With Epilepsy And Intellectual Disability, A. Gabrielsson, S. Tromans, H. Newman, P. Triantafyllopoulou, A. Hassiotis, P. Bassett, L. Watkins, I. Sawhney, M. Cooper, L. Griffiths, A. Pullen, A. Roy, H. Angus-Leppan, Rh Thomas, M. Kinney, P. Tittensor, R. Shankar

Peninsula Medical School

Background: Nearly a quarter of people with intellectual disability (ID) have epilepsy with large numbers experiencing drug-resistant epilepsy, and premature mortality. To mitigate epilepsy risks the environment and social care needs, particularly in professional care settings, need to be met. Purpose: To compare professional care groups as regards their subjective confidence and perceived responsibility when managing the need of people with ID and epilepsy. Method: A multi-agency expert panel developed a questionnaire with embedded case vignettes with quantitative and qualitative elements to understand training and confidence in the health and social determinants of people with ID and epilepsy. The cross-sectional …

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Cardiovascular Risk Factors In Secondary Progressive Multiple Sclerosis: A Cross‐Sectional Analysis From The Ms‐Stat2 Randomized Controlled Trial, Thomas Williams, Nevin John, Alberto Calvi, Alessia Bianchi, Floriana De Angelis, Anisha Doshi, Sarah Wright, Madiha Shatila, Marios C. Yiannakas, Fatima Chowdhury, Jon Stutters, Antonio Ricciardi, Ferran Prados, David Macmanus, Marie Braisher, James Blackstone, Olga Ciccarelli, Cam Gandini Wheeler‐Kingshott, Frederik Barkhof, Jeremy Chataway, Jeremy Hobart Jan 2023

Cardiovascular Risk Factors In Secondary Progressive Multiple Sclerosis: A Cross‐Sectional Analysis From The Ms‐Stat2 Randomized Controlled Trial, Thomas Williams, Nevin John, Alberto Calvi, Alessia Bianchi, Floriana De Angelis, Anisha Doshi, Sarah Wright, Madiha Shatila, Marios C. Yiannakas, Fatima Chowdhury, Jon Stutters, Antonio Ricciardi, Ferran Prados, David Macmanus, Marie Braisher, James Blackstone, Olga Ciccarelli, Cam Gandini Wheeler‐Kingshott, Frederik Barkhof, Jeremy Chataway, Jeremy Hobart

Peninsula Medical School

Background and purpose.There is increasing evidence that cardiovascular risk (CVR) contributes to disability progression in multiple sclerosis (MS). CVR is particularly prevalent in secondary progressive MS (SPMS) and can be quantified through validated composite CVR scores. The aim was to examine the cross‐sectional relationships between excess modifiable CVR, whole and regional brain atrophy on magnetic resonance imaging, and disability in patients with SPMS. Methods. Participants had SPMS, and data were collected at enrolment into the MS‐STAT2 trial. Composite CVR scores were calculated using the QRISK3 software. Prematurely achieved CVR due to modifiable risk factors was expressed as QRISK3 premature CVR, …

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Poo Matters! A Scoping Review Of Impact Of Constipation On Epilepsy, Alexandra Gabrielsson, Samuel Tromans, Lance Watkins, Lisa Burrows, Richard Laugharne, Rohit Shankar Jan 2023

Poo Matters! A Scoping Review Of Impact Of Constipation On Epilepsy, Alexandra Gabrielsson, Samuel Tromans, Lance Watkins, Lisa Burrows, Richard Laugharne, Rohit Shankar

Peninsula Medical School

BACKGROUND: Epilepsy is a common neurological disorder which frequently presents with co-morbid physical health conditions, including constipation. However, the nature of the relationship between the two conditions has not been well defined. AIM: To quantify constipation's relationship with epilepsy and anti-seizure medication (ASM). METHOD: A scoping review registered on PROSPERO (CRD42022320079) with suitable search terms was conducted and reported in accordance with PRISMA guidance. CINAHL, Embase, PsycInfo and MEDLINE electronic databases were searched by an information specialist. The Joanna Briggs Institute (JBI) critical appraisal tools alongside the Oxford Centre for Evidence Based Medicine (OCEBM) levels of evidence were used to …

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Fast-Track Extubation After Orthotopic Liver Transplant Associates With Reduced Incidence Of Acute Kidney Injury And Renal Replacement Therapy: A Propensity-Matched Analysis, J Fabes, G Wells, Z Abdi, R Bhatia, P Muehlschlegel, M Fortune-Ely, D Krzanicki, S Rahman, M Spiro Jan 2023

Fast-Track Extubation After Orthotopic Liver Transplant Associates With Reduced Incidence Of Acute Kidney Injury And Renal Replacement Therapy: A Propensity-Matched Analysis, J Fabes, G Wells, Z Abdi, R Bhatia, P Muehlschlegel, M Fortune-Ely, D Krzanicki, S Rahman, M Spiro

Peninsula Medical School

Introduction Liver transplantation is the only available definitive treatment for end-stage liver disease and subtypes of hepatocellular carcinoma. Patient outcomes have significantly improved alongside developments in surgical technique, peri-operative patient optimisation and post-transplantation management [1]. However, it remains a high risk procedure with significant morbidity and mortality attributable in the short term largely to surgical complications and rejection, and in the longer term to organ dysfunction and malignancy, often related to immunosuppressive medication [2,3]. Due to the challenges inherent to the surgical procedure, traditional post-operative management has been to maintain a period of clinical observation while the patient remains mechanically …

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A Distributional Synoptic Perspective On The So-Called "Historical Present" Tense Of Mark's Gospel, Oliver Glanz Jan 2023

A Distributional Synoptic Perspective On The So-Called "Historical Present" Tense Of Mark's Gospel, Oliver Glanz

Faculty Publications

No abstract provided.

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