Digital Commons Network^™

Framing Of Immigration: The Discussion Of Immigration And Its Influence On The American Identity, Nathan Torabi

The Crown: Syracuse Honors Research Journal

No abstract provided.

Carbon Sequestration, Conservation, And Capitalism: An Analysis Of West Virginia’S Senate Bill 162, Heleina Cicero

The Crown: Syracuse Honors Research Journal

No abstract provided.

The Property Contract: The Role Of Property In Social Contract Theory, Ellen Clark

The Crown: Syracuse Honors Research Journal

No abstract provided.

Viaje A Lo Desconocido Una Colección De Poemas | Journey To The Unknown A Collection Of Poems, Eadin Block

The Crown: Syracuse Honors Research Journal

No abstract provided.

Unfair To Compare: Why Assumptions Shouldn’T Authorize Discourse, Gianna Rullo

The Crown: Syracuse Honors Research Journal

No abstract provided.

Hydrofoil: The History Of A Cold War Weapon-Turned Personal Recreation Gadget, Yida "Rick" Li

The Crown: Syracuse Honors Research Journal

No abstract provided.

The Crown, Complete Issue - V1, The Crown

The Crown: Syracuse Honors Research Journal

No abstract provided.

Screening For Uterine Fibroids In Black Women, Winnie N. Kagendo

Doctor of Nursing Practice (DNP) Projects

Background: Uterine fibroids are benign growths in the uterine muscle that affect around 70% of women. Black women have a higher risk, with three times the likelihood of developing fibroids compared to other races.

Problem: The issue of uterine fibroids continues to be poorly addressed in healthcare settings. Black women continue to be particularly adversely impacted by this problem. There is a lack of better screening methods, leading to late detection and limited treatment options for those hoping to maintain fertility.

Methods: A quality improvement project was implemented at a primary care clinic in Loma Linda, California, using the Uterine …

Enhancing Mental Health Assessments For Hysterectomy Patients: Implementing A Depression Screening Tool For Healthcare Clinicians, Dede Mihedji

Doctor of Nursing Practice (DNP) Projects

Background: Hysterectomies are prevalent in the United States ranging from

5.1 to 5.8 per 1000 women (Harnod et al., 2018). A standardized screening tool for assessing preoperative depression could mitigate the worsening of postoperative depressive symptoms in patients scheduled for a hysterectomy. Local Problem: Currently, there is no standard practice for preoperative depression screening in hysterectomy patients. Studies have identified that a hysterectomy may increase the risk of cardiovascular events, menopause, depression, and other outcomes (Madueke-Laveaux et al., 2022). Methods: To address the gap, clinicians attended a fifteen-minute Zoom course on the Patient Health Questionnaire 9 (PHQ-9) and its …

Inequality In Opportunities And Outcomes: Indicators To Inform Data-Driven Community Systems For Youth Physical Activity, Ann Essay

Theses & Dissertations

Indicators illuminating whole-of-community and setting system physical activity (PA) outcomes and drivers are needed to inform population health improvement efforts. This multi-study dissertation examines inequalities in PA resources, opportunities, and outcomes and the factors influencing inequalities across multiple temporal and geospatial scales (e.g., community, setting). First, a scoping review examined community-level variability in PA resource and opportunity availability by community sociodemographic characteristics (e.g., race). Across 46 included studies, 41 unique indicators characterizing community PA systems were identified, and 29.8% of relationships assessed indicated greater resource/opportunity availability in communities of higher socioeconomic status or lower minority population prevalence. The indicators synthesized …

Usp1 Expression Driven By Ews::Fli1 Dually Promotes Ewing Sarcoma Cell Survival By Mitigating The Replication Stress Response And Stabilizing Survivin, Halle Mallard

Theses & Dissertations

Ewing sarcoma (EWS) is a malignant pediatric bone cancer. EWS express a fusion oncogene resulting from the reciprocal translocation of EWSR1 an ETS transcription factor. In most EWS tumors, this occurs with FLI1, creating the EWS::FLI1 fusion oncogene which encodes an aberrant transcription factor. Independent of its transcriptional activity, EWS::FLI1 deregulates other cellular processes driving oncogenesis. For cases with a single, localized tumor, roughly 80% of patients remain event-free after five years. Disease dissemination is a problem – about 25% of patients have metastatic disease at diagnosis. Long-term survival for these patients is less than 40%. Presently, no second line …

The Role Of Pre- And Perinatal Oxycodone Exposure On Postnatal Brain Development And Behavior: Assessing The Impact On Later Life Brain Injuries In Juvenile Rats, Austin M. Gowen

Theses & Dissertations

There has been a long history of research investigating the role of the gestational environment on later life health and disease. The progressive widespread illicit and prescribed use of opioids in the 21^st century has seen opioids become one of the most significant gestational insults in the last century. The ability of opioids to pass both the placental barrier and blood-brain barrier makes them a particularly dangerous teratogen capable of altering the peripheral physiology, neurobiology, and behavior of affected children. The works herein investigate the impact of a widely prescribed opioid, oxycodone, on developmental neurobiology in the context of …

Paper-Based Ratiometric Sensor Array For Pathogenic Bacterial Species Identification, Aayushi Laliwala

Theses & Dissertations

Bacterial infections are the leading cause of mortality worldwide due to the lack of accurate diagnosis of the pathogens causing infections. Currently, microbiological and molecular techniques are used to identify pathogenic bacteria. However, these techniques have limitations as they are time-consuming, cost-inefficient, and require trained personnel. Therefore, timely and precise identification of pathogenic bacteria is crucial for public safety. Our lab previously synthesized a fluorescent sensor array (3-hydroxyflavone derivatives) encapsulated in hyaluronic acid-based nanoparticles to identify bacterial species and recognize their Gram status. Though promising, this technique was relatively time-consuming and required high sample and volumes.

To overcome these limitations, …

Citrullinated And Malondialdehyde-Acetaldehyde Modified Proteins Promote Cellular Inflammatory And Fibrotic Responses Associated With Rheumatoid Arthritis, Nozima Aripova

Theses & Dissertations

Rheumatoid arthritis (RA) is a systemic, autoimmune disease primarily characterized by perpetual synovial inflammation that results in synovial tissue proliferation and fibrosis (pannus). Although joint involvement is the predominant manifestation of RA, extra-articular features, such as interstitial lung disease (ILD), contribute significantly to the elevated mortality associated with the condition. Post-translational modifications play a significant role in RA and RA-ILD pathogenesis. Circulating anti-citrullinated protein antibodies (ACPAs) are a highly diagnostic tool implicating a potential role for citrullinated antigens in RA and RA-ILD.

Recently, antibodies to malondialdehyde acetaldehyde adducts (MAA) have been markedly elevated in patients with RA and RA-ILD. MAA …

Towards A Mode Of Action For The Anti-Schistosomal Aryl Hydantoins, Thomas Schulze

Theses & Dissertations

Schistosomiasis is a significant human disease caused by the helminth parasite Schistosoma mansoni. Praziquantel remains the only clinically used treatment, yet it is rapidly metabolized and only effective against the adult stage worm infection. Ro 13-3978 (AR02) is a potent antischistosomal compound with activity against multiple S. mansoni life stages; however, it manifests anti-androgenic activity. Additionally, the mechanism of action for worm clearance remains unknown. The structure of Ro 13-3979 was used to generate optimized derivatives, including AR102, that show increased potency towards worms, reduced off-target anti-androgen effects, and extended half-life thereby increasing the feasibility for a single-dose curative treatment. …

Understanding The Effect Of Chikungunya Virus Infection On Bone Homeostasis, Enakshi Roy

Theses & Dissertations

Chikungunya virus (CHIKV) is a mosquito-borne virus that causes Chikungunya fever (CHIKF), characterized by high fever, headache, rash, and joint pain. With global travel on the rise, infections caused by CHIKV have emerged in new regions, expanding their geographic range and infecting susceptible hosts. Currently, no approved prophylactic or therapeutic measures exist to prevent or treat these infections, with prevention strategies primarily focused on vector control. However, these measures have proven inadequate due to the emergence of mutations that enhance viral transmission or vector range. Therefore, urgent attention is needed to develop therapies to treat the infection. Although CHIKV has …

A Multiple Methods Study To Describe The Manifestation Of Burnout Of Nebraska Physical Therapists, Nicole M. Sleddens

Theses & Dissertations

The extent of burnout within the profession of physical therapy remains relatively unexplored despite the widespread national attention given to burnout among other healthcare professionals. The purpose of this pilot study was to describe the current state of burnout of physical therapists in Nebraska using a multiple methods approach.

The quantitative phase of the study utilized a cross-sectional design and survey to measure burnout levels and identify associated characteristics of 407 practicing physical therapists in Nebraska. According to the Maslach Burnout Inventory, approximately half the sample exhibited engagement while the other half experienced at least one dimension of burnout. The …

Targeting Metabolic Switches And Dna Damage Repair For The Treatment Of Human Diseases, Rasangi Chathurika Kankanam Pathirage

Theses & Dissertations

Tuberculosis and Cancer treatments share common challenges due to prolonged therapy, the necessity of combination therapy and severe side effects. Characterization of novel drug targets and identification of new drugs modulating such targets within the context of multidrug treatments will contribute to overcoming current therapeutic challenges.

Tuberculosis (TB) is one of the challenging diseases to treat due to the persistence of Mycobacterium tuberculosis (Mtb) in the dormant phase. Current TB drugs are more effective toward actively dividing bacteria and less effective toward dormant bacteria. The metabolic transition between actively dividing bacteria and dormant bacteria is driven by pivotal metabolic enzymes …

Synergetic Signaling Between The Chlamydia Secreted Effectors Tarp And Tmea Regulates Actin Kinetics And Efficient Entry, Matthew Romero

Theses & Dissertations

Chlamydia trachomatis is both the leading cause of non-congenital preventable blindness in developing nations and the leading source of bacterial sexually transmitted infections. As an obligate intracellular pathogen, Chlamydia has an absolute requirement on gaining entry into its host, which is accomplished by manipulating the host actin cytoskeleton to assemble engulfment structures that drive pathogen entry. In support of this, Chlamydia secretes the effectors TarP and TmeA via a type-III secretion system, whose respective signaling outputs operate synergistically to generate rapid actin kinetics and efficient pathogen engulfment. Rapid actin recruitment characteristic of invading Chlamydia is derived from a collaborative interaction …

A Mixed Methods Study Of Physical Activity In The Intensive Care Unit And Post-Intensive Care Unit Hospital Stay: Patient Characteristics, Symptom Burden, And Experiences Of Postoperative Adults, Christina Bach

Theses & Dissertations

Background: Physical activity (PA) beginning early in the intensive care unit (ICU) can reduce adverse outcomes commonly experienced by individuals after ICU discharge. Patient-centered approaches to PA in the ICU and reliable activity evaluations are essential for understanding PA's impact on patient outcomes.

Objective: This dissertation sought to evaluate patient-related factors associated with PA in the ICU and post-ICU hospital stay.

Methods: The purpose of the dissertation was to conduct: 1) a concept analysis to define ICU survivorship and identify critical care aspects important for patient recovery; 2) an integrative literature review to assess early mobility (EM) interventions with physical, …

Applications Of The Re-Aim Framework In Health Promotion, Emiliane L. Pereira

Theses & Dissertations

This dissertation applied a variety of methods under the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework and provided a valuable and relevant contribution to the field of the dissemination and implementation (D&I) science. In the first study, we applied the RE-AIM framework to evaluate interventions and summarize the literature on breastfeeding promotion programs on the Black population (Chapter 1). The study results provide meaningful findings by bridging the gap on the literature of reporting breastfeeding supporting services and resources available to ensure breastfeeding continuation, as well as the need for a better reporting on the individual-level and setting representativeness, …

A Community-Based Participatory Research Approach To Addressing Pediatric Asthma Disparities In Douglas County, Nebraska, Aislinn Rookwood

Theses & Dissertations

Pediatric asthma is the leading chronic disease among children in the United States, and the incidence of pediatric asthma is increasing every year. Nebraska has an asthma prevalence comparable to the United States average; however, the state has significant disparities by county, race, and geographic location, with prevalence rates much higher than the national average. Douglas County is a hot spot for increased pediatric asthma rates, with further differences in rates by race and geographic location within the county. The University of Nebraska Medical Center, in partnership with Healthy Housing Omaha and the Nebraska Asthma Coalition, collaborated to conduct this …

Examining Teacher Leadership: Phenomenology Of The Perceived Challenges Of Being A Teacher Leader, Noelle H. Green

The Interactive Journal of Global Leadership and Learning Infographics

Today’s school leaders recognize that one person, mainly the principal, cannot adequately address the needs of all members of the school community. Many principals rely on teacher leaders to lead alongside them to further school improvement, knowing that the traditional way of thinking of school leadership as being the sole role of the principal is no longer effective or efficient. While K-12 teachers typically have a strong background in child development, psychology, and pedagogy, many lack experience in leading and facilitating adults and have little background in adult learning theory.

The purpose of this research is to determine how K-12 …

Designing Effective Online Courses: Exploring The Relationships Amongst Online Teaching Self-Efficacy, Professional Development, Online Teaching Experience, And Reported Implementation Of Effective Higher Education Online Course Design Practices, Elizabeth Mcmahon

The Interactive Journal of Global Leadership and Learning Infographics

How best to prepare and support higher education faculty to design and teach effective online courses is a topic of great significance to higher education institutional leaders and faculty developers. This study explored how hours of professional development along with online teaching and learning experiences were related to online teaching self-efficacy and the extent to which participants reported implementation of effective online course design practices. Using a non-experimental quantitative correlational explanatory research study design, data were collected using a questionnaire. Participants included 104 online faculty from a large public higher education system located in the upper Midwest that includes both …

Targeting Macrophytes: Increased Water Quality Through Optimized Vegetation Considerations For Constructed Wetlands, Austin Mcbrady

Masters Theses (Archived)

This study of constructed wetland design investigated relationships between macrophyte species selection and planting density for water quality improvement. A lab-scale wetland was compared against a pilot-scale wetland in San Antonio, Texas at Mitchell Lake to measure differences in effluent water quality improvement using three native macrophyte species. Using a novel, two-phase method, a targeting macrophyte was identified from among other species based on its marked capability for improving water quality factors, then was planted in varied majority densities to compare differences in treatment effectiveness. The results of this study showed that this complimentary approach to wetland design displayed significant …

Investigating The Curricular Practices Of Social Innovation Master’S Programs In The United States, Ty M. Krueger

Masters Projects

The study of social innovation in higher education has increased as more schools add undergraduate and graduate programs on the broad topic. Discussion on what should be included as part of social innovation education has been occurring for decades, but there is little determination as to what could be considered as standards or even a baseline for curricular practices. This research aims to look at how current graduate programs for social innovation are defining the topic, what courses they include in their curriculum, what teaching methods are used in the delivery of these topics, and how the topics and teaching …

Functional Cynicism, Michelle Fried

Electronic Theses and Dissertations

Trait cynicism, or “cynical hostility” as measured by the Minnesota Multiphasic Personality Inventory’s Cook-Medley Scale, is defined and studied as characteristics associated with psychopathology, interpersonal conflict, and negative health outcomes including heart disease and cognitive decline. Likewise, “organizational cynicism” is operationalized in industrial/organizational psychology for the purpose of describing and identifying an undesirable employee type in the workplace. This research proposes an alternative assessment. It reconnects cynicism with its roots in ancient philosophy by asking if cynical attitudes, despite their negative valence ascribed in the modern literature and conventional opinion, may serve a practical purpose. This study of Functional Cynicism …

Religious Freedom In A Secular Age: A Christian Case For Liberty, Equality, And Secular Government, Jeff Stevenson

Witness

No abstract provided.

Diversity And Dissemination Of Viruses In Pathogenic Protozoa, Senne Heeren, Ilse Maes, Mandy Sanders, Lon-Fye Lye, Vanessa Adaui, Jorge Arevalo, Alejandro Llanos-Cuentas, Lineth Garcia, Philippe Lemey, Stephen M Beverley, James A Cotton, Jean-Claude Dujardin, Frederik Van Den Broeck

2020-Current year OA Pubs

Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis and their dsRNA Leishmania virus 1. We show that parasite populations circulate in tropical rainforests and are associated with single viral lineages that appear in low prevalence. In contrast, groups of hybrid parasites …

Cut Flower Markets And Marketing In The Intermountain West, Makylie Langford, Kynda R. Curtis, Melanie Stock

All Current Publications

This fact sheet discusses different markets for cut flowers in the Intermountain West, including wholesale and direct-to-consumer markets. Farmers markets, community-supported agriculture and subscription services, u-pick operations, farm venues, and online options are explored, as well as using social media to advertise and build clientele.