Digital Commons Network^™

Combining The Tyrosine Kinase Inhibitor Cabozantinib And The Mtorc1/2 Inhibitor Sapanisertib Blocks Erk Pathway Activity And Suppresses Tumor Growth In Renal Cell Carcinoma., Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Yuefan Wang, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L Mudd, Jeremy Hoog, R Jay Mashl, Matthew A Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M Herndon, Sherri R Davies, Di Liu, Xi Ding, Yvonne A Evrard, Bryan E Welm, David Lum, Mei Yee Koh, Alana L Welm, Jeffrey Chuang, Jeffrey A Moscow, Funda Meric-Bernstam, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C Fields, Kian-Huat Lim, Cynthia X Ma, Hui Zhang, Li Ding, Feng Chen

Faculty Research 2023

UNLABELLED: Current treatment approaches for renal cell carcinoma (RCC) face challenges in achieving durable tumor responses due to tumor heterogeneity and drug resistance. Combination therapies that leverage tumor molecular profiles could offer an avenue for enhancing treatment efficacy and addressing the limitations of current therapies. To identify effective strategies for treating RCC, we selected ten drugs guided by tumor biology to test in six RCC patient-derived xenograft (PDX) models. The multitargeted tyrosine kinase inhibitor (TKI) cabozantinib and mTORC1/2 inhibitor sapanisertib emerged as the most effective drugs, particularly when combined. The combination demonstrated favorable tolerability and inhibited tumor growth or induced …

The Association Between Prenatal Acetaminophen Use And Adhd Development In Childhood, Jocelyne Blanco, Erika Mccarthy, Justin Gambini

Doctor of Medical Science (DMSc)

Background: The purpose of this article is to produce a review of the literature on a recently growing topic of interest. We believe the widespread use of acetaminophen in pregnancy makes the rising concern for acetaminophen use in pregnancy and the development of childhood attention deficit hyperactivity disorder (ADHD) a national public health matter. The mechanism of action of acetaminophen, the pathophysiology of drug transfer through the placental barrier, and the most up-to-date research studies were analyzed with the goal of bringing clarity and promoting healthy pregnancies for all.

Methods: PubMed, PLOS One, and Google Scholar served as the cornerstone …

Beyond The Physical Wounds: A Proactive Approach To Mental Health Recovery After A Traumatic Injury, Christine Mcgahey

Doctor of Nursing Practice (DNP) Projects

Beyond the Physical Wounds: A Proactive Approach to Mental Health Recovery After a Traumatic Injury

Background: Every year, millions of Americans incur a life-threatening traumatic event and are admitted to trauma centers to treat their acute physical injuries. While traumatic injury is closely associated with developing post-traumatic stress disorder (PTSD), patients are rarely evaluated for PTSD risk or educated about long-term psychological sequelae.

Local Problem: The predictive value of early screening to quantify PTSD risk in trauma patients is well documented in the literature. However, in a 241-bed Level II Trauma acute care hospital, there was no protocol to evaluate …

Introducing The Arts To The K-6 Classroom (Cc-Version), Lynn University Digital Press, Brittany E. Kiser

CC-COMPLIANT LYNN DIGITAL PRESS BOOKS

CC-COMPLIANT VERSION

The contents of Introducing the Arts to the K-6 Classroom: A Compilation of Open Educational Resources (OERs) is a compendium that is intended to familiarize the pre-service teacher with the arts in the elementary school. Throughout this Multi-Touch Book, the reader will explore the how and why behind integration of the arts as these can be applied in sync with the core curriculum of the K-6 classroom, as well as to delve into research, strategies, and examples of addressing visual art, music, and movement (in the form of dance, drama, and other physical activities) in this learning environment. …

Type Vs. Turnout: Correlations Between Types Of Higher Education Institutions And Student Voter Turnout, Janea Mccoy

Undergraduate Honors Theses

Voter turnout in the youth demographic has been the subject of increased attention and research in the past several years, with many questions left unanswered. The 18-25 age demographic can play a crucial and impactful role in elections. However, many young adults do not vote. Higher education has often been viewed as a catalyst for civic engagement amongst this age demographic, with correlations between enrollment in higher education and increased rates of voter turnout being evident. Given there is much variation between different kinds of institutions, however, this raises the question: what types of institutions and their respective characteristics correlate …

A Man Ahead Of His Time: Lee Kuan Yew’S Iron First Beneath The Velvet Glove, Yi Chen Zhai

Master's Projects and Capstones

This study examines the role of Lee Kuan Yew, the founding father of Singapore, in the country's development from a third-world nation to a first-world economic powerhouse. Lee Kuan Yew was the Prime Minister of Singapore for over three decades and was responsible for implementing policies that transformed Singapore's economy, infrastructure, education, and social systems. This paper analyzes the various policies and strategies, as well as personal values and ideologies, adopted and implemented by Lee Kuan Yew that were instrumental in Singapore's growth. Additionally, the paper discusses the challenges faced by Lee Kuan Yew during his leadership in his public …

Data Quality: Integral To Cauti Surveillance And Improvement In Non-Critical Care Units, Mary Grace Daria

Master's Projects and Capstones

Background: Urinary tract infections (UTIs) are the most common type of healthcare-acquired infection (HAI), with 75% approximately associated with urinary catheter use. The key to preventing UTIs is to avoid the use of indwelling urinary catheters (IUCs). This study explores denominator data extract logic modifications to increase IUC data capture and accuracy. It is set in a 249-bed acute care, teaching hospital in the Diablo Service Area in Northern California.

Problem: The electronic system used to extract the CAUTI denominator data is inconsistently capturing the IUC device days from the electronic medical record (EMR). This has regulatory reporting ramifications and …

Social Determinants Of Health: Evidence-Based Practices For Hospitals To Screen And Address Their Patients’ Needs, Lanna N. Anderson

Master's Projects and Capstones

There is an increasing acknowledgment that addressing the specific social, economic, and environmental factors contributing to health inequalities would improve the overall health and wellbeing of individuals. Arguably, hospitals and other healthcare systems are getting more conscious of their responsibilities in dealing with SDOHs, with an increase need to address these SDOHs to improve patients' healthcare outcomes and lessen the prevailing healthcare inequalities. To reach this aim, there is a need for screening and addressing SDOH at different levels, including healthcare system. This paper examined the existing evidence-based practices that screen and address social determinants of health (SDOH) among disadvantaged …

Toxic Fashion: Evaluation Of Chemicals In Clothing And Recommendations For The Amended Tsca, Gregory Zajac

Master's Projects and Capstones

The fashion industry is one of the largest polluting industries in the world and its rising environmental impact is partly due to the dominance of fast fashion business models. Recently researchers and advocates have found that large amounts of chemicals are used by textile manufacturers to produce clothing, some proven to be toxic in other applications. The risk of exposure to these classes of chemicals is a growing concern. With the risk management model, a qualitative examination was conducted on existing policies in the United States that regulate chemicals used by the industry. Despite some policy changes regarding chemical exposure …

Non-Clinical Perspectives On Sepsis: A Project For Enhanced Awareness, Anjali Kumari Singh

Master's Projects and Capstones

Problem: This project aimed to enhance non-clinical staff knowledge of sepsis through a targeted awareness campaign, while also seeking to uphold or enhance the organization's sepsis-related performance.

Context: Clinical Nurse Leader students conducted a microsystem assessment in five crucial non-clinical departments of an urban Bay Area hospital, each playing a vital role in the organization's efficiency at different levels.

Intervention: During Sepsis Awareness Month, a sepsis awareness campaign was implemented. This involved a concise presentation on sepsis, its consequences, and the significance of awareness in each department. Additionally, informational fliers detailing sepsis signs and symptoms were distributed.

Measures: A pre-and …

Campaigning Beyond: Sepsis Awareness Among Non-Clinical Staff, Cynthia Wong

Master's Projects and Capstones

Problem: Sepsis stands as the foremost cause of illness and death among hospitalized patients globally, yet a considerable number remain oblivious to this critical condition. Based on the pre-implementation survey among non-clinical staff members of an urban hospital, awareness of sepsis must be heightened to ensure swift recognition and response.

Context: The project conducted takes place in five distinct non-clinical departments at a large hospital organization in Northern California. Each department plays an essential role in the holistic and efficient functioning of the organization to provide quality patient care.

Interventions: A sepsis awareness campaign was implemented throughout the month of …

Optimizing Sepsis Management Through Enhanced Protocol Compliance In The Emergency Department, Emily Beck

Master's Projects and Capstones

Problem: With a recent influx of sepsis cases, hospital stakeholders identified gaps between sepsis protocol and practice. This quality improvement project aimed to increase sepsis bundle compliance and utilization among registered nursing staff in the emergency department to improve sepsis management and patient outcomes ultimately.

Context: The microsystem assessed is a 44-bed emergency department at Hospital A, a level II adult trauma center within the greater San Francisco Bay Area. The current registered nurse roster within this department, excluding four on leave, is 115 individuals and represents the target population for this change project.

Interventions: Interventions were not implemented due …

Best Practices To Manage Nitrate Contamination Of Groundwater In Agricultural Zones: A Comparative Analysis Of Farming Impacts On Areas Of Central Valley And High Plains Aquifers, Rekha Duthulur

Master's Projects and Capstones

Nitrate is one of the most common contaminants in groundwater and causes multiple health impacts when consumed. Contamination is most significant in agricultural areas and has increased steadily since the 1950s with the introduction of nitrogen fertilizers. The depth of an aquifer, sediment type, hydrogeology, redox conditions, microbe activity, fertilizer application, natural nitrogen deposits, and well construction influence the degree of nitrate contamination of an aquifer. The sources of nitrate pollution are fertilizer, manure, concentrated feeding lots, natural nitrogen deposits, atmospheric deposition, septic systems, wastewater treatment plants, and industrial activities. Nitrogen compounds applied on the surface are stored in the …

Assessing Wastewater Treatment In Yopal Colombia Using Gis, Leydi P. Puerto Bohorquez

Master's Projects and Capstones

The amount of wastewater has surged alongside population growth, urbanization, and economic development, which can influence the wastewater treatment process, especially in the treatment capacity, particularly in developing countries. In Colombia, the low coverage of Wastewater Treatment Plants (WWTP) leads to a complex environmental issue. This has threatened water quality and aquatic ecosystems of waterbodies that receive this type of water by increasing disease prevalence and creating hypoxic conditions. To determine how a WWTP could impact water quality, it was necessary to understand the treatment process and the physicochemical parameters being monitored. The focus is to answer the central research …

Addressing Linguistic Isolation Through Community Based Esl And Emergency Preparedness, Lisa Guay

Master's Projects and Capstones

Linguistic isolation acts as a barrier to the well-being and social integration of Limited English Proficient (LEP) adults. Community-based English as a Second Language (ESL) classes, designed with learner-centric curricula, may help LEPs gain access to social and navigational capital in the form of English proficiency, confidence and social integration. Community-based ESL programs provide adult English Language Learners (ELLs) with a path to English proficiency and social integration, but curricula should be geared toward ELLs’ needs. There is a need for ESL curricula focused on emergency and disaster preparedness, curricula which may contribute positively to adult ELLs’ speaking skills and …

Association Of Covid-19 Coinfection With Increased Mortality Among Patients With Pseudomonas Aeruginosa Bloodstream Infection In The Veterans Health Administration System, Leila S. Hojat, Brigid M. Wilson, Federico Perez, Maria F. Mojica, Mendel E. Singer, Robert A. Bonomo

Faculty Scholarship

Objective: Pseudomonas aeruginosa bloodstream infection (PA-BSI) and COVID-19 are independently associated with high mortality. We sought to demonstrate the impact of COVID-19 coinfection on patients with PA-BSI. Design: Retrospective cohort study. Setting: Veterans Health Administration. Patients: Hospitalized patients with PA-BSI in pre-COVID-19 (January 2009 to December 2019) and COVID-19 (January 2020 to June 2022) periods. Patients in the COVID-19 period were further stratified by the presence or absence of concomitant COVID-19 infection. Methods: We characterized trends in resistance, treatment, and mortality over the study period. Multivariable logistic regression and modified Poisson analyses were used to determine the association between COVID-19 …

Reducing Hospital-Acquired Pressure Injury In An Inpatient Medical-Surgical Telemetry Adult Unit By Educating And Encouraging Basic Wound Care Prior To Wound Care Consult, See Wai (Amy) Kong

Master's Projects and Capstones

Problem: A medical center in the Diablo Service Area had one of the highest rates in hospital-acquired pressure injury (HAPI), benchmarking with other facilities, with the project unit one of the top offenders. The patients and the medical center both suffered from the harm. Barriers to HAPI prevention included lack of patient turnings, skin assessment, and early standard wound care treatment.

Context: This project focused on the primary care team standardizing early wound care treatment to avoid wound progression.

Interventions: Interventions included re-educating the primary care team on early basic wound care using a standard wound care guideline created by …

Reducing Care Companion Utilization In Medical-Surgical And Telemetry Units, Mary Jane B. Sagabaen

Master's Projects and Capstones

Abstract

Problem: The facility highly utilized sitters or care companions, negatively impacting the staffing plan, budget, and productivity. An average of 56 hours of care companions were used daily. This greatly exceeded the budget of 33 hours a day. Reassigning Patient Care Technicians (PCT) as care companions resulted in inadequate nurse support for patient care and increased cost for additional staffing needs. Despite this, the fall rate remained higher than the target.

Context: The patient population is mainly 65 years old and above, sometimes with confusion, dementia, delirium, and at high risk for falls and elopement. The culture included promptly …

Utility Of T-Cell Immunosequencing In Distinguishing Mycosis Fungoides Progression From Treatment Related Cutaneous Adverse Events, Safiyyah Bhatti, Daniel Joffe, Lauren Banner, Sahithi Talasila, Jenna Mandel, Jason Lee, Pierluigi Porcu, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

Cutaneous adverse events of both topical and systemic drugs in patients with mycosis fungoides (MF) present a diagnostic challenge as it is often difficult to distinguish drug associated rash from disease progression in the skin. Mogamulizumab and mechlorethamine gel are approved treatments for MF, both of which can cause treatment related cutaneous adverse events. It can often be challenging to distinguish mogamulizumab associated rash (MAR) and mechlorethamine gel associated hypersensitivity dermatitis from MF progression both clinically and histologically. High-throughput sequencing (HTS) of the T-cell receptor (TCR), also known as immunosequencing, can be used to assess T-cell clonality to support a …

Letter To Our Readers, Mecca Wilkinson

DePaul Journal for Social Justice

No abstract provided.

The Constitutional Ambition Of Black Liberation, Paul A. Gowder

DePaul Journal for Social Justice

No abstract provided.

Table Of Contents, Mecca Wilkinson

DePaul Journal for Social Justice

No abstract provided.

Staff, The Crown

The Crown: Syracuse Honors Research Journal

No abstract provided.

Green Nation Building: Children’S Book Authors In The Arab World, Christian Bevilacqua

The Crown: Syracuse Honors Research Journal

No abstract provided.

About The Authors - V1, The Crown

The Crown: Syracuse Honors Research Journal

No abstract provided.

The Perfect Storm: Social Media Addiction, Mental Health, And Post-Pandemic College Life, Kira Donegan

The Crown: Syracuse Honors Research Journal

No abstract provided.

World Without End: Vita Nova Xlii, Anne C. Leone

Languages, Literatures, and Linguistics - All Scholarship

The point I would like to make about this chapter is related to what Barański and Ledda claim: the last chapter of the Vita nova is also a beginning. Of course, in the most basic and functional sense, by declaring the hope to write of his beloved what has never been said of “alcuna,” the final chapter of the libello announces the beginning of a new work. Yet, the issue of what that new work is (or will be) has divided critics. Mark Musa and Robert Pogue Harrison have each referred to the final chapter as an admission of the …

Meeting Of The Executive Committee - Notice And Agenda 12/15/2022, Uc Hastings Board Of Directors

2022 Board of Directors Agenda and Materials

No abstract provided.

Comparative Analysis Of Interacting Stepped Dark Radiation, N. Schöneberg, G. F. Abellán, T. Simon, A. Bartlett, Y. Patel, Tristan L. Smith

Physics & Astronomy Faculty Works

Models that address both the Hubble and S₈ tensions with the same mechanism generically cause a prerecombination suppression of the small scale matter power spectrum. Here we focus on two such models. Both models introduce a self-interacting dark radiation fluid scattering with dark matter, which has a step in its abundance around some transition redshift. In one model, the interaction is weak and with all of the dark matter whereas in the other it is strong but with only a fraction of the dark matter. The weakly interacting case is able to address both tensions simultaneously and provide a …

The Regime And The Opera House: A Study Of Teatro Dell’Opera Di Roma, Yifan Shen

The Crown: Syracuse Honors Research Journal

No abstract provided.