Digital Commons Network^™

Rethinking The Presumption Of Enablement In Nonpatent Prior Art, Gabrielle Carlini

Duke Law Journal

The rising popularity of tools such as preprint servers, open-access data sources, and generative artificial intelligence has resulted in a proliferation of prior art that has never been seen before under the current patent system. In a rapidly changing world, patent law is slow to catch up, and the current system is not equipped to handle the flood of incoming prior art. In the academic research setting in particular, while the use of preprint servers and open-source data has allowed researchers to participate in widespread information exchange, these tools have also generated a new, large class of prior art dedicated …

The Role Of Young Architects As Entrepreneurship Generational Units In Shaping The Future Of Architecture, Attaa H. Al Obaidi, Anwar. S. Al-Qaraghuli

Al-Esraa University College Journal for Engineering Sciences

Youth are the pillar of nations and the secret of their renaissance, thebuilders of their civilization and the line of defense, the main participants inbasic planning processes, and the agents of change to build a world that iscompatible with the aspirations of future generations. This applies to the field ofarchitecture in terms of the importance of young architects in shaping it underthe challenges it faces, which impose interaction in a manner commensuratewith the emerging requirements and needs. This research is based on theconsideration that young architects are an integrated phenomenon thatcontributes to shaping architectural production according to the data of …

Sustainability Post-Graduation: Energy Industry, George Anderson

Sustainability Institute Blog

No abstract provided.

Pursuing Social Justice Through Visual Practice: Intro To Part Iv, Stephanie Beene

University Libraries & Learning Sciences Faculty and Staff Publications

This peer-reviewed chapter serves as the Introduction to the final section of the book, Unframing the Visual: Visual Literacy Pedagogy in Academic Libraries and Information Spaces, edited by Maggie Murphy, Stephanie Beene, Katie Greer, Sara Schumacher, and Dana Statton Thompson, and published by the Association of College & Research Libraries (2023). As the introduction to the final section of the book, it introduces readers to the final theme of the 2022 Framework for Visual Literacy in Higher Education, a Companion Document (VL Framework) to the 2016 Framework for Information Literacy for Higher Education, “Learners …

Nanoparticles Used In Treatment And Diagnosis Of Leishmaniasis In Iraq: A Review, Harith S. Al-Warid, Layla M. Hasan

Al-Esraa University College Journal for Medical Sciences

The aim of this paper is to identify Nano-particles that have been used in diagnosis and treatment of leishmaniasis in Iraq. All experiments conducted in this field were based on the following nanoparticles: gold nanoparticles, silver nanoparticles, zinc nanoparticles, and sodium chloride nanoparticles. Most of these experiments were reviewed in terms of differences in the concentrations of nanoparticles and the method that was used in the experiments whether it was in vivo or in vitro. These particles used in most experiments succeeded in inhibiting the growth of Leishmania parasites.

Pseudomonas Aeruginosa Epidemiology And Antibiotic Resistance: A Five Years Retrospective Study In Iraq., Huda Ghassan Hameed

Al-Esraa University College Journal for Medical Sciences

One of the leading causes of diseases and deaths across the world are bacterial infections, and the situation is only going to grow worse as antibiotic resistance spreads. Antimicrobial resistance must be closely monitored so as to control the spread of multi-antibiotic-resistant microorganisms. As a result, the goal for the study was to estimate the prevalence of Pseudomonas aeruginosa infection on top of that to look into the antibacterial pattern over the last five years. This retrospective investigation was carried out in various hospitals in Iraq like Central Children's Teaching Hospital for Children, Al Kindi Teaching Hospital, Al-Numan Hospital, Yarmouk …

Risk Detection Of Gestational Diabetes In Early Pregnancy Depend On Artificial Neural Network, Sanaa Hammad Dhahi

Al-Esraa University College Journal for Engineering Sciences

Early prediction of gestational diabetes mellitus (GDM) risk is particularly important because it may enable more effective interventions and reduce cumulative maternal and fetal injury. The aim of this study is to develop machine learning (ML) models for early prediction of GDM using widely available variables, facilitating early intervention, and enabling the application of prediction models in settings where more complex tests are not accessible. In this paper, an artificial neural network (ANN) was used to detect the risk of gestational diabetes. A global dataset was used to collect clinical and experimental data from pregnant women and people with diabetes …

Riverton Sq., Llc V. New York State Div. Of Hous. & Community Renewal

All Decisions

No abstract provided.

Matter Of 225 Cent. Park N. Llc V. New York State Div. Of Hous. & Community Renewal

All Decisions

No abstract provided.

The Neutrosophic Regular And Most Important Properties That Bind Neutrosophic Ring Elements, Murhaf Riad Alabdullah

Neutrosophic Sets and Systems

No abstract provided.

Solving Neutrosophic Zero-Sum Two-Person Matrix Game Using Mellin’S Transform, Gaurav Sharma, Sapan Kumar Das, Ganesh Kumar

Neutrosophic Sets and Systems

No abstract provided.

An Enhanced Generalized Neutrosophic Number And Its Role In Multi-Criteria Decision-Making Challenges, Sumathi I. R, Augus Kurian, Parvathy K

Neutrosophic Sets and Systems

No abstract provided.

Text Analysis Using Morphological Operations On A Neutrosophic Text Hypergraph, Dhanya Pm, Ramkumar P. B

Neutrosophic Sets and Systems

No abstract provided.

Waste To Energy Treatment For India Using Critic-Waspas Method Under Interval-Valued Pythagorean Neutrosophic Fuzzy Set, R.Narmada Devi, S. Sowmiya, R. Sundareswaran, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Sets And Systems, Vol. 61,2023, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

The Concise Guide To Pharmacology 2023/24: Catalytic Receptors, Stephen P.H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Doris Koesling, Michaela Kuhn, David Macewan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H.H.W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It …

Evaluation Of A Targeted Covid-19 Community Outreach Intervention: Case Report For Precision Public Health, Isela De La Cerda, Cici X Bauer, Kehe Zhang, Miryoung Lee, Michelle Jones, Arturo Rodriguez, Joseph B Mccormick, Susan P Fisher-Hoch

Faculty, Staff and Student Publications

BACKGROUND: Cameron County, a low-income south Texas-Mexico border county marked by severe health disparities, was consistently among the top counties with the highest COVID-19 mortality in Texas at the onset of the pandemic. The disparity in COVID-19 burden within Texas counties revealed the need for effective interventions to address the specific needs of local health departments and their communities. Publicly available COVID-19 surveillance data were not sufficiently timely or granular to deliver such targeted interventions. An agency-academic collaboration in Cameron used novel geographic information science methods to produce granular COVID-19 surveillance data. These data were used to strategically target an …

The Potential For Development Of Clinically Relevant Microbial Resistance To Rifaximin-Α: A Narrative Review, Herbert L Dupont

Faculty, Staff and Student Publications

Rifaximin-α is a gut-targeted antibiotic indicated for numerous gastrointestinal and liver diseases. Its multifaceted mechanism of action goes beyond direct antimicrobial effects, including alterations in bacterial virulence, cytoprotective effects on host epithelial cells, improvement of impaired intestinal permeability, and reduction of proinflammatory cytokine expression via activation of the pregnane X receptor. Rifaximin-α is virtually non-absorbed, with low systemic drug levels contributing to its excellent safety profile. While there are high concentrations of drug in the colon, low water solubility leads to low colonic drug bioavailability, protecting the gut microbiome. Rifaximin-α appears to be more active in the bile-rich small bowel. …

Prt543, A Protein Arginine Methyltransferase 5 Inhibitor, In Patients With Advanced Adenoid Cystic Carcinoma: An Open-Label, Phase I Dose-Expansion Study, Renata Ferrarotto, Paul Swiecicki, Dan Zandberg, Robert Baiocchi, Robert Wesolowski, Cristina Rodriguez, Meredith Mckean, Hyunseok Kang, Varun Monga, Rajneesh Nath, Neil Palmisiano, Naveen Babbar, William Sun, Glenn Hanna

Department of Medical Oncology Faculty Papers

OBJECTIVES: Currently, no systemic treatments are approved for patients with recurrent and/or metastatic (R/M) adenoid cystic carcinoma (ACC). PRT543, a protein arginine methyltransferase 5 inhibitor that downregulates NOTCH1 and MYB signalling in tumours, is a potential candidate for R/M ACC treatment. We report the safety, tolerability and preliminary efficacy of PRT543 in a dose-expansion cohort of patients with R/M ACC.

MATERIALS AND METHODS: This phase I multicentre, open-label, sequential-cohort, dose-escalation and dose-expansion study (NCT03886831) enrolled patients with advanced solid tumours and select haematologic malignancies. Dose-escalation study design and results were reported previously. In the dose expansion, patients with R/M ACC …

Develop Sciences And Technologies To Support The Building Of A Beautiful China In All Respects—Preface On Special Issue “Efforts From Science And Technology To Promote The Building Of A Beautiful China In All Respects”, Quansheng Ge

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Ecological Operation In Yangtze River Basin With Yangtze River Simulator, Jun Xia, Zhonghui Lin, Chesheng Zhan, Wenjuan Gao, Yunliang Li, Jing Yao, Sidong Zeng, Renyong Huang, Hongzhu Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Ecological protection and green development in the Yangtze River basin are critical to the ecological construction of a Beautiful China. This study analyzes the current situation and main problems of the water ecology in the Yangtze River basin, and introduces the development of the Yangtze River Simulator, and the design for the ecological operation of the Three Gorges Reservoir, the main river, and the lakes connected to the river. Through the simulation of the main stream water ecology and lake water ecology by the Yangtze River Simulator, the optimization plan for the ecological regulation of the Three Gorges Reservoir was …

Opportunities And Challenges In Monitoring Cultivated Land Red Line In Big Data Era, Jinwei Dong, Yifeng Cui, Yuanyuan Di, Xuan Gao, Xi Chen, Linsheng Yang, Yumei Cai, Jia Ning, Jiyuan Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The demographic reality of a large population and limited land resources in China necessitates the implementation of the world’s most stringent cultivated land protection system. Effective, timely, and accurate monitoring of the status of cultivated land protection red line is essential to ensuring cultivated land protection and food security. The development of cutting-edge technologies such as remote sensing big data, cloud computing, and artificial intelligence has provided new opportunities for cultivated land control and monitoring. This article systematically elaborates on the current research status and challenges in the field of cultivated land protection redline control and monitoring, including the establishment …

Synergism Utilization Of Urban Multi-Source Solid Waste And District Green Recycling Development—Taking Dongguan Haixinsha National Resource Recycling Demonstration Base As An Example, Yao Shi, Huiquan Li, Shaohua Chen, Weiqiang Chen, Caihong Xiong, Songgeng Li, Yin Wang, Peng Qian, Shuangde Li, Chao Hua, Ping Lu, Yupeng Liu, Chenmu Zhang, Jianwen Chu, Xin Lu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The long-term storage and extensive disposal of solid waste have caused serious water soil air composite pollution. It is necessary to strengthen the scientific and effective utilization of solid waste, which is not only conducive to solving the major pollution problem of solid waste, but also alleviates the shortage of resources and energy in China. This study summarizes three typical types of urban solid waste comprehensive treatment experience models, and points out that the solid waste circular economy model characterized by centralization, resource utilization, and greening is the main way to solve the complex problem of solid waste. Therefore, it …

Innovation And Practice On Biodiversity Conservation In Sanjiangyuan National Park, Xinquan Zhao, Shixiao Xu, Liang Zhao, Tongzuo Zhang, Linyong Hu, Qi Li, Tongqing Guo

Bulletin of Chinese Academy of Sciences (Chinese Version)

Sanjiangyuan National Park, is one of the first batch of national parks in China, and serves as the largest national park in China. As an important ecological security barrier and a alpine biological germplasm resource base, it has significant conservation value in China and even in the world. Lots of protocols have been taken aiming at ecological tacking protection issues including loss of biodiversity and wildlife habitats, degradation of alpine grassland and overgrazing in Sanjiangyuan National Park. It promotes the implementation of major ecological restoration projects, and has formed the Sanjiangyuan National Park Biodiversity Conservation and Ecological Protection Program with …

Synthetical Solution Of Disaster Risk Reduction And Green Development: A Novel Mode Promoting High-Quality Development In Mountain Areas Of China, Ming Li, Qin Liu, Yukuan Wang, Peng Cui, Xing Gao, Baofeng Di, Jinfeng Liu, Shengwen Qi, Rong Chen, Chunping Tan, Mengzhen Xu, Hao Sun, Jianqiang Zhang, Jiangang Chen, Qiang Zou

Bulletin of Chinese Academy of Sciences (Chinese Version)

China is a mountainous country, with hills, mountains, and plateaus cover about two-thirds of its total land area. The vast area, huge population, rich natural resources, and great potential of development in mountain areas make them the most important “rear garden” supporting the sustainable development of the whole country. Nevertheless, China’s mountain areas are also prone to various kinds of natural disasters, and thus formed a scenario of high overlap between the high-risk zone of natural disasters and the lagging zone of social and economic development. And such scenario has caused significant waste of various related inputs, and becoming a …

Atmospheric 14Co2 Observation: A Novel Method To Evaluate Carbon Emissions, Zhenchuan Niu, Peng Wang, Shugang Wu, Weijian Zhou

Bulletin of Chinese Academy of Sciences (Chinese Version)

As an important carbon emitter, China faces the stress of carbon peaking and carbon neutrality goals and international carbon reduction duty. The accurate data of carbon emissions are important to evaluate the carbon peaking and carbon neutrality goals and fulfill the international duty of carbon reduction. The Intergovernmental Panel on Climate Change (IPCC) report recommends the combination of top-down atmospheric CO₂ observation with atmospheric inversion to verify the bottom-up inventory of carbon emissions, and the atmospheric ¹⁴CO₂ observation can make the verification more accurate. Radiocarbon (14C) is the most precise tracer of fossil fuel CO₂ and …

Challenges And Countermeasures For Treatment And Remediation Of Contaminated Mega-Sites In China, Xiaoyong Liao, Yixuan Hou, You Li, Tianyi Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The treatment and remediation of pollution at contaminated mega-sites poses a significant challenge in the environmental science both domestically and internationally. Contaminated mega-sites are characterized by their widespread impact, multiple types of pollutants, and significant ecological and environmental threats. The environmental behavior cognition and efficient remediation at contaminated mega-sites face enormous challenges, among which key technological issues such as the formation mechanism of soil and groundwater pollution, accurate identification of pollution sources, and intelligent decision-making optimization urgently need to be solved. In China, contaminated mega-sites are concentrated in economically developed regions such as Beijing-Tianjin-Hebei, the Yangtze River Economic Belt, and …

Scenario Simulation Of “35 Goals” And “50 Vision” For Beautiful China Initiative, Huiyi Zhu, Linsheng Yang, Wei Qi, Erqi Xu, Jiewei Chen, Quansheng Ge

Bulletin of Chinese Academy of Sciences (Chinese Version)

Realizing the Beautiful China Initiative is the general goal of China’s ecological civilization construction in the next 30 years. The overall goal includes two phased goals: “35 goals” and “50 vision”. This study first expounds the understanding of the goal from the aspects of ecosystem elements, structure, process, and function, and then constructs an index system to describe the goal and simulates the “35 goals” and “50 vision” under the trend of climate change, population decline and economic growth. The results show that, by 2035, China will have a population of 1.44 billion (including Hong Kong, Macao, and Taiwan) and …

An Innovative Restoration Mode “Macrophytes–Fishes–Benthons–Birds” Implemented In Aesthetic Plateau Wetlands, Junxing Yang, Xiaoai Wang, Xiaofu Pan, Yuanwe Zhang, Heqi Wu, Anli Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Affected by both increasing human activities and climate change, Yunnan Plateau lakes were faced with threats such as water level decreasing, water-body reducing, and severe pollution. Many indigenous species were endangered or even disappeared. The ecological restorations implemented since 1980s almost all used alien species. As an inevitable result, severe negative impacts from alien species were observed on the Plateau wetland ecosystem and indigenous species. To solve these problems, with the support of relevant projects, an innovative restoration mode mainly with indigenous flag-species “macrophytes – fishes – benthons – birds” was proposed. This innovative mode was implemented respectively in Dianchi …

Ten Problems And Solutions For Restoration Of Karst Ecosystem In Southwest China, Xiaoyong Bai, Sirui Zhang, Chen Ran, Luhua Wu, Chaochao Du, Lei Dai, Xingyi Yang, Zilin Li, Yingying Xue, Mingkang Long, Minghui Li, Shu Yang, Qing Luo, Xiaoyun Zhang, Xiaoqian Shen, Fei Chen, Qin Li, Yuanhong Deng, Zeyin Hu, Chaojun Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

The karst areas in southwest China are one of the key but difficult areas targeted in the “Beautiful China” construction initiative, which focuses on soil erosion, proportion of farmland, water pollution, karst drought, ecological restoration, carbon sink, ecological effects of urbanization, rocky desertification management indicators, and biodiversity and sustainability assessment. The study synthesizes the knowledge accumulated during ecological restoration practice in karst areas into 10 problems and solutions that are strong, universal and empirically supported. These problems and solutions help to explain the challenges of achieving sustainability in karst ecology restoration and thus point to solutions. They constitute a core …