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Blastocyst Quality And Reproductive And Perinatal Outcomes: A Multinational Multicentre Observational Study, Haowen Zou, James M. Kemper, Elizabeth R. Hammond, Fengqin Xu, Gensheng Liu, Lintao Xue, Xiaohong Bai, Hongqing Liao, Songguo Xue, Shuqin Zhao, Lan Xia, Jean Scott, Vincent Chapple, Masoud Afnan, Dean E. Morbeck, Ben W. J. Mol, Yanhe Liu, Rui Wang

Research outputs 2022 to 2026

STUDY QUESTION: Does the transfer of single low-grade blastocysts result in acceptable reproductive and perinatal outcomes compared to the transfer of single good-grade blastocysts? SUMMARY ANSWER: The transfer of single low-grade blastocysts resulted in a reduced live birth rate of around 30% (14% for very low-grade blastocysts) compared to 44% for single good-grade blastocysts, but does not lead to more adverse perinatal outcomes. WHAT IS KNOWN ALREADY: It is known that low-grade blastocysts can result in live births. However, the current studies are limited by relatively small sample sizes and single-centre designs. Furthermore, evidence on perinatal outcomes after transferring low-grade …

Nutritional Strategies To Optimise Musculoskeletal Health For Fall And Fracture Prevention: Looking Beyond Calcium, Vitamin D And Protein, James Webster, Jack Dalla Via, Christina Langley, Cassandra Smith, Craig Sale, Marc Sim

Research outputs 2022 to 2026

Falls and osteoporotic fractures are a major public health problem, particularly among older adults. A third of individuals aged 65 years and over fall at least once each year, with up to 20 % of these resulting in serious injury, including fracture. In conjunction with regular exercise, the importance of diet for musculoskeletal health has largely focused upon calcium, vitamin D, and protein, particularly in the context of preventing falls and fractures. Whilst there is evidence for the benefits of these nutrients for musculoskeletal health, other aspects of the diet remain largely underexplored. For example, vegetables are rich sources of …

The Kneeling Isometric Plantar Flexor Test: Preliminary Reliability And Feasibility In Professional Youth Football, John J. Mcmahon, Nicholas J. Ripley, Paul Comfort, Francisco J. Robles-Palazón, Jack T. Fahey, Andrew J. Badby, Christopher Bramah

Research outputs 2022 to 2026

Calf injuries are common in professional football; thus, the establishment of reliable and time-efficient methods of measuring the peak force capabilities of the plantar flexors with equipment that is accessible to football practitioners is valuable. In this study, we determined the preliminary reliability and feasibility of a new test, termed the kneeling isometric plantar flexion test (KIPFT), for footballers. Twenty-one male youth footballers (age = 17.8 ± 1.1 years, height = 182 ± 5 cm, weight = 77.6 ± 5.9 kg) from English League One football clubs completed three trials of the KIPFT on a wireless force plate at the …

Physiological And Biomechanical Response To Indoor Cycling With And Without The Ability To Sway, Alina P. Swafford

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Bicycles have been around since the early 19th century. Since the invention of the bicycle, it has taken on several purposes. People have used bicycles as a means of transportation, leisure, exercise, and sport. The number of individuals who participate in a cycling event per year has increased. With the increase in popularity, research related to cycling has also increased. Research related to the physiology and biomechanics of cycling are of particular areas of interest. Balance is a crucial component of understanding why we cycle a certain way. Some research has labeled balancing on a bicycle as cycling sway. …

Placental Co-Culture Model Reveals Listeria Monocytogenes Utilization Of Monocytes For Vertical Transmission, Breanna Mackenzie Amelunke

Online Theses and Dissertations

Listeria monocytogenes is an opportunistic pathogen that can cross the protective placental barrier and infect the fetus, leading to congenital disabilities or death. Extracellular L. monocytogenes infection of the placenta has been well studied; however, the bacteria have not been observed translocating this barrier intracellularly. As an intracellular pathogen, L. monocytogenes could infect phagocytic cells that can be transported across the placental barrier. A novel cell co-culture system comprised of BeWo and HPVEC cell lines was established to model the human placental barrier. Barrier integrity was confirmed using immunostaining of tight junctions and a FITC-dextran permeability assay. The model was …

Climate Change And The Shifting Geography Of Coral-Reef Development, Victor Rodriguez-Ruano

Theses and Dissertations

Coral-reef development is modulated by growth processes that deposit calcium carbonate onto the reef, such as calcification, and destructive processes that remove calcium carbonate from the reef, such as bioerosion. Wherever calcification rates exceed bioerosion rates, there is a net accretion of the reef through time, but where bioerosion rates exceed calcification rates, there is a net destruction of the reef through time. A reef’s framework is the legacy of the interaction of these processes throughout a reef’s history. Studying the fossil frameworks of reefs can shed light on the environmental factors that have controlled reef development in the past, …

The Therapeutic Role Of Lm11a-31 (A P75ntr Modulator) In The Outcome Of Ischemic Stroke And Hiv-1 Pathogenesis, Golnoush Mirzahosseini

Theses and Dissertations (ETD)

The objective of this research project is to explore the potential therapeutic role of LM11A-31 in both ischemic stroke and human immunodeficiency virus-1 (HIV-1) infection. There are limited treatment options for ischemic stroke, with tissue plasminogen activator (tPA) being the only effective medication and a narrow administration window, which is also accompanied with the high incidence of ischemic stroke in HIV-1 infected individuals. Therefore, it is critical to explore an effective therapeutic agent to address the urgent medical need. LM11A-31 is a p75 neurotrophin receptor (p75NTR) modulator and is orally bioavailable, and it can penetrate the intact blood-brain barrier (BBB). …

Improving Estimation Of Coronary Artery Disease Risk Using Haptoglobin Genotyping, Emily Kate Mewborn

Theses and Dissertations (ETD)

Atherosclerotic cardiovascular disease (ASCVD) continues to be the leading cause of death worldwide. While several risk factors contributing to disease progression are well-known, pitfalls and limitations exist for estimating if or when an individual will develop the disease. Coronary artery disease (CAD), a subtype of ASCVD, causes myocardial infarction, contributing to significant morbidity and mortality. Current ASCVD risk estimator calculators lack comprehensiveness and do not include genetic or social determinants of health information, which are known to affect ASCVD risk.

Haptoglobin (Hp) genotype also influences CAD risk. Hp is a protein that binds free hemoglobin released from physiologic or pathologic …

From There To Here: How Black Women From Areas Of Black-Concentrated Poverty Understand, Generate, And Use Social Capital To Influence Economic Mobility: An Interpretive Phenomenological Analysis, Tatiana C. Parker

Education Doctoral

This qualitative, interpretative phenomenological study investigated how Black women, with experience residing in areas of concentrated Black poverty in Syracuse, New York between the ages of 25 and 34, understood, generated, and utilized the social capital within their networks. The research also sought to understand these women’s perspectives regarding the role of network social connections in their economic mobility. Four one-on-one interviews were conducted and, through the lens of networking social capital theory, revealed significant themes, including the role of proximity in relationship dynamics, access points such as educational institutions and workplaces, and the influence of guidance and character congruency …

Comparing Bone Histology, Topography, And Other Physical Attributes To The Presence Of Viable Dna After Interval Cremation, Eldad Cano Jr

Student Theses

This research aims to compare the resulting characteristics caused by thermal exposure to bone samples – such as physical composition, microscopic histology, and scanning electron microscopy (SEM) analysis – to the qualitative and quantitative DNA analysis within the samples. By using kilns to cremate sus scrofa domesticus bone samples at five different temperatures, cortical and cancellous bones of the tibia, humerus, femur, and fibula will be analyzed and compared to determine any correlation with these factors and the presence of viable DNA. This contribution to research within the realm of forensic anthropology can grant a better understanding of how bone …

Conquering And Combating Isolation, Nicholas Deanda

Capstone Projects and Master's Theses

The Conquering and Combating Isolation initiative, implemented by an OMNI Resource Center intern, addressed severe isolation issues among individuals with mental health disabilities in Salinas, California. The macro-level problem encompassed the adverse effects of isolation on mental health and well-being. At the micro-level, the agency-specific issue was the heightened risk of unhealthy habits, depression and anxiety, and suicidal ideation among OMNI clients due to loneliness caused by homelessness, stigma, and a lack of social skills. The project entailed facilitating weekly peer support group discussions to minimize impacts of isolation, aiming for increased knowledge and skill-building. Findings revealed positive outcomes as …

Support Families’ Increased Access To Dental Care, Carmen Barron

Capstone Projects and Master's Theses

The Monterey County Oral Health Program is a program of the Monterey County Health Department housed under the Chronic Disease and Injury Prevention Unit. The Oral Health Program focuses on providing educational workshops to parents and classroom presentations to Kindergarten and first graders students. They provide services to schools that have a rate of 80% or higher of students enrolled in Free or Reduced-Price meals (FRPM). Studies show that minority students with low socioeconomic status (SES) have higher rates of untreated cavities in their primary teeth than non-Hispanic White students. The purpose of this project is to provide and educate …

Expanding Recognition And Inclusion Of Animal-Free Organic Agriculture In The Sustainable Agriculture Movement, Mona Seymour

Urban and Environmental Studies Faculty Works

Animal-free organic agriculture resides at the margins of sustainable agriculture discourse, practice, and imaginaries, which center animal-based forms of farming. However, the concerns and goals of sustainable agriculture are overwhelmingly consistent with those of many forms of animal-free organic agriculture (AFOA), described as organic farming sans animal production, labor, and byproducts. Despite this sidelining, AFOA has great potential to contribute to a more robust sustainable agriculture movement. In order to emphasize the continuities between animal-based and animal-free sustainable agriculture, this Perspective identifies a number of key similarities between animal-free and animal-based sustainable farming, including mutual foci on soil health and …

The Quiet And Other Fantastical Tales, Emily Nicole Cerda

Theses and Dissertations

This thesis briefly discusses the genres and subgenres of speculative fiction—focusing on fantasy, horror, and science fiction—and is primarily a short story collection that also includes a few novel chapters. The critical introduction delves into the present and overly complex subgenre categorization methods, how and why new subgenres are created, and provides simple definitions for the main genres of speculative fiction and fantasy subgenres.

The subgenres that will be discussed through either a short story, novel chapter(s), or definition include, but are not limited to: fairytales, portal fantasy, paranormal romance, dark fantasy, historical fantasy, magical realism, epic fantasy, mythic fiction, …

Aedes Aegypti Host Preference On Canines Versus Human Volatile Skin Compounds, Melissa Bernadette Rosalez

Theses and Dissertations

It is critical to understand how Aedes aegypti mosquitoes detect hosts through cues such as volatile skin compounds. In South Texas, evidence suggests that this mosquito is showing a feeding preference for canines over humans. This shift may impact the transmission of Dirofilaria immitis, canine heart worms, in local dog populations. Our study is set to explore Ae. Aegypti attraction to hosts using canine and human volatile compounds. Volatile skin compounds will be collected using a volatile collection system. Compounds will be analyzed using gas chromatography/mass spectrometry. It is anticipated that the main volatile skin compounds amongst humans are nonanal, …

Comparing Socioeconomic Status To Educational Diagnosis Of Serious Emotional Disturbances: A Linear Analysis Of Texas Data, Cristina Rangel

Theses and Dissertations

This dissertation was prepared to determine if a correlation existed between a student’s poverty level and an educational diagnosis of serious emotional disturbance. I hypothesize that students at or under the United States’ definition of poverty are more likely to exhibit signs and symptoms of a serious emotional disturbance and therefore be diagnosed and placed in special education. Both federal data (i.e., poverty levels) and Texas data (i.e., dx of SED) were compared to determine correlation and directionality. TEA combines districts into 20 regions. Special education placement data is publicly available on State databases. Federal poverty levels are available …

Meeting Students’ Needs To Improve Motivation And Higher Academic Achievement In Rio Grande Valley Schools, Tanya Jessica Reyes

Theses and Dissertations

Educational systems are to prepare students for future success in our ever-changing world. Administrators must realize that before a student is willing to learn, crucial needs must be met, especially in low-socioeconomic areas such as the Rio Grande Valley. Some basic needs consist of food and shelter, which are vital for survival. Other needs deal with one’s social and emotional needs that support a child's safety, sense of belonging, and their self-esteem. In this study, focus groups were conducted with sixth, seventh, and eighth grade student participants that gathered the phenomenon of their experiences and their fulfillment of needs …

Intestinal Microbiome, Fecal Fermentation Profile, And Health Indices In Hiv Infected Men Versus Non-Infected Controls, Mary Andreae, Mary C. Andreae Mrs

Electronic Theses and Dissertations

Many HIV-positive (HIV+) males on Highly Active Anti-Retroviral Therapy (HAART) experience metabolic abnormalities, including Non-Alcoholic Fatty Liver Disease (NAFLD) and lipodystrophy. The intestinal microbiota and short chain fatty acids (SCFA), participate in bidirectional communication with their host. Dysbiosis in HIV+ males on HAART demonstrate a Prevotella-rich enterotype shaped by multiple factors including, medications, adiposity, diet, intestinal permeability, and lifestyle; our objective was to investigate these factors. 19 HIV+ and 21 HIV- males were enrolled. BMI and hip-to-waist ratio (H:W) were obtained, and FibroScan for liver health. Intestinal permeability markers Claudin-21, flagellin, and intestinal fatty acid binding protein (IFABP) in …

Repeated Treatment With 5-Ht1a And 5-Ht1b Receptor Agonists: Evidence Of Tolerance And Behavioral Sensitization, Jordan Taylor

Electronic Theses, Projects, and Dissertations

Serotonin has been found to regulate several cognitive and physiological functions, and its role in depression and other neuropsychiatric disorders has been a focus of research. More specifically, a wealth of research regarding serotonin focuses on serotonergic medications in the treatment of neuropsychiatric disorders, such as depression and anxiety, and stimulates the 5-HT_1A and 5-HT_1B receptors. Within the last decade, there has been an increase in prescriptions of psychotropic medication for children, however, the efficacy and adverse effects of these drugs have not been evaluated in younger populations. While antidepressants reduce symptoms of depression in adults, they are …

A Genome Wide Association Study Of Heat Tolerance In Snap Bean (Phaseolus Vulgaris), Morgan Stone

All Theses

Bean production in the United States has decreased while the temperatures have been steadily increasing, reaching new highs each year. Heat stress is detrimental to common bean (also known as snap bean) production. Symptoms of heat stress include decrease in pollen viability, shriveling of pods, and pod abortion making them unmarketable. Pod production of 323 snap bean accessions from a large diversity panel was assessed in a randomized complete block design with field trials at two different times in the spring season. The results show a significant decrease in the number of pods produced per plant and weight of pods …

Rapid Leaf Senescence Symptoms Are Related To Carbohydrate Depletion In Cut Chrysanthemums, And Strategies For The Symptoms Reduction, Shara Ortiz Carvajal

All Theses

Chrysanthemum (Chrysanthemum ×morifolium) is the second-largest exported cut flower worldwide; however, some cultivars exhibit rapid leaf senescence during their first week of vase life. This phenomenon negatively impacts consumer perception of plant quality, and its cause has been unknown. Experiments were performed in Colombia on cut chrysanthemums shipped to the U.S. for vase-life evaluation. After 10 d, the severity of leaf senescence symptoms was recorded. Experiments examined the effect of flower form [disbud (one flower per stem) versus spray (5-10 flowers per stem)], the effect of time of harvest (A.M. versus P.M.), and sugar sources (dextrose, fructose, mannitol, and sucrose) …

Germination Trends Of American Chaffseed, Schwalbea Americana L., And Factors Affecting First-Year Seedling Development, Trenton Miller

All Theses

Following centuries of exploitation and fire suppression, longleaf pine systems are now the focus of many conservation efforts. Efforts to restore populations of Schwalbea americana L. in longleaf pine savannas have been met with frustratingly low recruitment. While past studies have briefly quantified germination rates for Schwalbea, there have not been any studies yet that truly investigate this plant’s germination requirements. Additionally, there has been little research into characterizing the parasitic relationship between Schwalbea and its various host species. We conducted a germination study in a growth chamber that investigated Schwalbea’s germination rate and time to germinates as …

Effect Of Storage Temperatures And Home Refrigeration Systems On The Shelf Life Of Frozen Desserts, Natalie Sinclair

All Theses

The effect of storage temperature over 12 weeks was studied using dairy and non-dairy frozen desserts. Research was conducted to determine if higher freezer temperatures affect frozen dessert quality to reduce energy use associated with lower freezer temperatures. Samples were analyzed for ice crystal pore size using micrographs, grittiness by a trained sensory panel and weight loss during storage. Ice crystal size was determined using scanning electron microscopy and grittiness was measured on a 5-point ranking scale, with 1 being least gritty and 5 being most gritty. Weight loss was determined by measuring sample weights before and after the 12-week …

Covid-19 Vaccine Uptake In The Hispanic And Latinx Communities Of Northeast Tennessee, Gabriela Abrego

Electronic Theses and Dissertations

This work addresses the underlying issues surrounding COVID-19 vaccine uptake in Hispanic and Latinx communities in the Northeast region of Tennessee. A qualitative, phenomenological research approach was used to conduct interviews and data from the interviews was used to inform a survey instrument. The interview guide in the qualitative phase of the study was based on the Health Belief Model (HBM) developed by Rosenstock (Rosenstock, 1974). A quantitative approach was then used by piloting the survey instrument in the study population. Common themes found through the interviews were: previous negative experience with COVID-19 vaccination, previous negative experience as a result …

Flavonol Glucosylation: A Structural Investigation Of The Flavonol Specific 3-O Glucosyltransferase Cp3gt, Aaron S. Birchfield

Electronic Theses and Dissertations

Flavonoid glycosyltransferases (GTs), enzymes integral to plant ecological responses and human pharmacology, necessitate rigorous structural elucidation to decipher their mechanistic function and substrate specificity, particularly given their role in the biotransformation of diverse pharmacological agents and natural products. This investigation delved into a comprehensive exploration of the flavonol 3-O GT from Citrus paradisi (Cp3GT), scrutinizing the impact of a c-terminal c-myc/6x histidine tag on its enzymatic activity and substrate specificity, and successfully achieving its purification to apparent homogeneity. This established a strong foundation for potential future crystallographic and other structure/function analyses. Through the strategic implementation of site-directed mutagenesis, a thrombin …

The Experiences Of Students During Covid-19 School Disruptions, Brandi Bullock

Electronic Theses and Dissertations

The purpose of this study was to identify the perceptions of educators with respect to student experiences between March 2020 and February 2021 related to academics, social-emotional health, and safety and security. Data collection strategies included one-on-one interviews with 12 educators in one East Tennessee school district. To qualify for the study, participants had to have taught during COVID-19 schooling disruptions and have taught either 1st, 2nd, 3rd, 4th, or 5th grade in the 2022-23 school year. Data analysis was based on Systems Theory (Laszlo & Krippner, 1998) and Change Theory (Fullan, 2020). The results revealed 5 key themes that …

Elucidation Of The Role Of Avocado Wri1 And Wri2 And Their Ability To Affect Oil Content And Composition When Co-Expressed With Pdat1 And Dgat1, Jyoti Ranjan Behera

Electronic Theses and Dissertations

Plants synthesize and store oil, mostly as triacylglycerols (TAG), in seeds that is transcriptionally controlled by WRINKLED1 (WRI1), an APETALA2 (AP2) transcription factor. Among the four Arabidopsis WRI paralogs, WRI2 is nonfunctional, while the others are expressed in a tissue-specific manner. Additionally, two rate-limiting enzymes, diacylglycerol acyltransferase (DGAT) and phospholipid diacylglycerol acyltransferase (PDAT) catalyze the terminal step in TAG assembly and contribute to oil accumulation. Avocado (Persea americana) mesocarp, a non-seed tissue, accumulates significant amounts of TAG (~70% by dry weight) enriched with heart-healthy oleic acid. The oil accumulation stages in mesocarp coincide with the high expression of …

Developing And Evaluating The Usability Of A Web-Based Diabetic Retinopathy Health Education Program For Patients With Type 2 Diabetes Mellitus, Rif’Atunnailah Mat Isa, Mei Chan Chong, Wan Ling Lee, Tajunisah Iqbal, Mardiana Mansor, Airul Azizan Zainudin

Saudi Medical Journal

Objectives: To describe the development of a webpage based on the Intervention Mapping (IM) protocol and usability testing of the Diabetic Retinopathy Health Education Profram (DRHEP). Methods: The mixed methods pilot feasibility study was carried out between April and September 2021, involving 16 patients with type 2 diabetes mellitus and 5 experts. The usability score was rated according to the System Usability Scale (SUS). Results: The average SUS score by the experts was 88. The patients gave a higher score of 85 for SUS, with 58 as the lowest. The average SUS score was 72. The findings indicate that the …

The Determinants Of Creator Performance On Creative Content Platforms: Evidence From Xiaohongshu And Bilibili, Caijun Xu

Dissertations and Theses Collection (Open Access)

Content creation platforms, including Douyin, Kuaishou, Xiaohongshu, and Bilibili, have emerged as significant drivers of employment and economic growth within the digital economy. These platforms invigorate online engagement and offline consumption, serving as vital conduits that merge China’s digital and real economies. Currently, China boasts over 10 million active content creators on its leading platforms, although their earnings are markedly uneven. While some top-tier creators garner substantial profits, the majority in the mid to lower tiers grapple with profit generation and encounter challenges in enhancing their creative performance. Against this background, this study delves into the antecedents of creative performance. …

Correlations Between Educational Struggle, Toxic Sites By School District And Demographic Variables, With Geographical Information System Projections, Junu Shrestha, Raihan K. Khan, Shane Mcclintock, John Degroote, Catherine L. Zeman

Faculty Publications

This correlational study associated data on children enrolled in individualized educational plans in their K-12 schools (IEP) and an algorithm-calculated score of neurotoxins at contaminated sites located in each school district. The study also mapped and projected the correlations using Geographical Information System (GIS) technology. These data were populated in ArcMap 10.5 (a GIS software) for generating maps and data to conduct geospatial analysis. A total of 1 Superfund site and 39 CERCLA sites were identified as contaminated sites for this analysis. The majority of contaminants were heavy metals such as lead, arsenic, mercury, and cadmium. The mean toxic score …