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2023

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A Scalable, Virtual Weight Management Program Tailored For Adults With Type 2 Diabetes: Effects On Glycemic Control, John W. Apolzan, Jessica Gokee Larose, Stephen D. Anton, Robbie A. Beyl, Frank L. Greenway, Edmond P. Wickham, Autumn Lanoye, Melissa N. Harris, Corby K. Martin, Tiffany Bullard, Gary D. Foster, Michelle I. Cardel Dec 2023

A Scalable, Virtual Weight Management Program Tailored For Adults With Type 2 Diabetes: Effects On Glycemic Control, John W. Apolzan, Jessica Gokee Larose, Stephen D. Anton, Robbie A. Beyl, Frank L. Greenway, Edmond P. Wickham, Autumn Lanoye, Melissa N. Harris, Corby K. Martin, Tiffany Bullard, Gary D. Foster, Michelle I. Cardel

Clinical Research Faculty Publications

Background: The objective was to test the efficacy of a scalable, virtually delivered, diabetes-tailored weight management program on glycemic control in adults with type 2 diabetes (T2D). Methods: This was a single arm, three-site clinical trial. Participants had baseline HbA1c between 7–11% and BMI between 27–50 kg/m2. Primary outcome was change in HbA1c at 24 weeks. Secondary outcomes were changes in body weight, waist circumference, the Diabetes Distress Scale (DDS), quality of life (IWQOL-L), and hunger (VAS). Generalized linear effects models were used for statistical analysis. Results: Participants (n = 136) were 56.8 ± 0.8 y (Mean ± SEM), 36.9 …

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The Influence Of Salinity And Vegetation Texture On The Ecological Roles Of Insects In Tidal Marshes In Louisiana, Benjamin G. Aker, Claudia Husseneder, Lane D. Foil Dec 2023

The Influence Of Salinity And Vegetation Texture On The Ecological Roles Of Insects In Tidal Marshes In Louisiana, Benjamin G. Aker, Claudia Husseneder, Lane D. Foil

Faculty Publications

Tidal marsh insect communities are influenced by both salinity and aspects of vegetation texture (vegetation diversity, plant density, and architectural structure). These factors affect the abundances and intra- and interguild interactions of these insects and should result in broad-scale variation in the distribution and ecological functioning of tidal marsh insect communities along these gradients. However, this assumption has not been tested within Gulf Coast marshes, and the insect communities and their ecological roles are not well known. This study identifies how family-level insect biodiversity varies by salinity and which factors are most important in affecting the distribution of insect functional …

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New Insights In The Mechanisms Of Weight-Loss Maintenance: Summary From A Pennington Symposium, Emily W. Flanagan, Redin Spann, Sarah E. Berry, Hans Rudolf Berthoud, Stephanie Broyles, Gary D. Foster, Jonathan Krakoff, Ruth J.F. Loos, Michael R. Lowe, Danielle M. Ostendorf, Tiffany M. Powell-Wiley, Leanne M. Redman, Michael Rosenbaum, Philip R. Schauer, Randy J. Seeley, Boyd A. Swinburn, Kevin Hall, Eric Ravussin Dec 2023

New Insights In The Mechanisms Of Weight-Loss Maintenance: Summary From A Pennington Symposium, Emily W. Flanagan, Redin Spann, Sarah E. Berry, Hans Rudolf Berthoud, Stephanie Broyles, Gary D. Foster, Jonathan Krakoff, Ruth J.F. Loos, Michael R. Lowe, Danielle M. Ostendorf, Tiffany M. Powell-Wiley, Leanne M. Redman, Michael Rosenbaum, Philip R. Schauer, Randy J. Seeley, Boyd A. Swinburn, Kevin Hall, Eric Ravussin

Division of Basic Science Faculty Publications

Obesity is a chronic disease that affects more than 650 million adults worldwide. Obesity not only is a significant health concern on its own, but predisposes to cardiometabolic comorbidities, including coronary heart disease, dyslipidemia, hypertension, type 2 diabetes, and some cancers. Lifestyle interventions effectively promote weight loss of 5% to 10%, and pharmacological and surgical interventions even more, with some novel approved drugs inducing up to an average of 25% weight loss. Yet, maintaining weight loss over the long-term remains extremely challenging, and subsequent weight gain is typical. The mechanisms underlying weight regain remain to be fully elucidated. The purpose …

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Sensory Spinal Interoceptive Pathways And Energy Balance Regulation, Heike Münzberg, Hans Rudolf Berthoud, Winfried L. Neuhuber Dec 2023

Sensory Spinal Interoceptive Pathways And Energy Balance Regulation, Heike Münzberg, Hans Rudolf Berthoud, Winfried L. Neuhuber

Division of Basic Science Faculty Publications

Interoception plays an important role in homeostatic regulation of energy intake and metabolism. Major interoceptive pathways include gut-to-brain and adipose tissue-to brain signaling via vagal sensory nerves and hormones, such as leptin. However, signaling via spinal sensory neurons is rapidly emerging as an additional important signaling pathway. Here we provide an in-depth review of the known anatomy and functions of spinal sensory pathways and discuss potential mechanisms relevant for energy balance homeostasis in health and disease. Because sensory innervation by dorsal root ganglia (DRG) neurons goes far beyond vagally innervated viscera and includes adipose tissue, skeletal muscle, and skin, it …

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Dietary Intake During A Pragmatic Cluster-Randomized Weight Loss Trial In An Underserved Population In Primary Care, John W. Apolzan, Corby K. Martin, Robert L. Newton, Candice A. Myers, Connie L. Arnold, Terry C. Davis, William D. Johnson, Dachuan Zhang, Christoph Höchsmann, Vivian A. Fonseca, Kara D. Denstel, Emily F. Mire, Benjamin F. Springgate, Carl J. Lavie, Peter T. Katzmarzyk, Phillip Brantley, Ronald Horswell, Tina K. Thethi, Jonathan Gugel, Eboni Price-Haywood, Kathleen B. Kennedy, Daniel F. Sarpong Dec 2023

Dietary Intake During A Pragmatic Cluster-Randomized Weight Loss Trial In An Underserved Population In Primary Care, John W. Apolzan, Corby K. Martin, Robert L. Newton, Candice A. Myers, Connie L. Arnold, Terry C. Davis, William D. Johnson, Dachuan Zhang, Christoph Höchsmann, Vivian A. Fonseca, Kara D. Denstel, Emily F. Mire, Benjamin F. Springgate, Carl J. Lavie, Peter T. Katzmarzyk, Phillip Brantley, Ronald Horswell, Tina K. Thethi, Jonathan Gugel, Eboni Price-Haywood, Kathleen B. Kennedy, Daniel F. Sarpong

Clinical Research Faculty Publications

Background: Currently there are limited data as to whether dietary intake can be improved during pragmatic weight loss interventions in primary care in underserved individuals. Methods: Patients with obesity were recruited into the PROPEL trial, which randomized 18 clinics to either an intensive lifestyle intervention (ILI) or usual care (UC). At baseline and months 6, 12, and 24, fruit and vegetable (F/V) intake and fat intake was determined. Outcomes were analyzed by repeated-measures linear mixed-effects multilevel models and regression models, which included random cluster (clinic) effects. Secondary analyses examined the effects of race, sex, age, and food security status. Results: …

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The Personalized Nutrition Study (Points): Evaluation Of A Genetically Informed Weight Loss Approach, A Randomized Clinical Trial, Christoph Höchsmann, Shengping Yang, José M. Ordovás, James L. Dorling, Catherine M. Champagne, John W. Apolzan, Frank L. Greenway, Michelle I. Cardel, Gary D. Foster, Corby K. Martin Dec 2023

The Personalized Nutrition Study (Points): Evaluation Of A Genetically Informed Weight Loss Approach, A Randomized Clinical Trial, Christoph Höchsmann, Shengping Yang, José M. Ordovás, James L. Dorling, Catherine M. Champagne, John W. Apolzan, Frank L. Greenway, Michelle I. Cardel, Gary D. Foster, Corby K. Martin

Clinical Research Faculty Publications

Weight loss (WL) differences between isocaloric high-carbohydrate and high-fat diets are generally small; however, individual WL varies within diet groups. Genotype patterns may modify diet effects, with carbohydrate-responsive genotypes losing more weight on high-carbohydrate diets (and vice versa for fat-responsive genotypes). We investigated whether 12-week WL (kg, primary outcome) differs between genotype-concordant and genotype-discordant diets. In this 12-week single-center WL trial, 145 participants with overweight/obesity were identified a priori as fat-responders or carbohydrate-responders based on their combined genotypes at ten genetic variants and randomized to a high-fat (n = 73) or high-carbohydrate diet (n = 72), yielding 4 groups: (1) …

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Effect Of An Acute Long-Duration Exercise Bout On Skeletal Muscle Lipid Droplet Morphology, Glut 4 Protein, And Perilipin Protein Expression, Sudip Bajpeyi, Jehu N. Apaflo, Victoria Rosas, Keisha Sepulveda-Rivera, Armando Varela-Ramirez, Jeffrey D. Covington, Jose E. Galgani, Eric Ravussin Dec 2023

Effect Of An Acute Long-Duration Exercise Bout On Skeletal Muscle Lipid Droplet Morphology, Glut 4 Protein, And Perilipin Protein Expression, Sudip Bajpeyi, Jehu N. Apaflo, Victoria Rosas, Keisha Sepulveda-Rivera, Armando Varela-Ramirez, Jeffrey D. Covington, Jose E. Galgani, Eric Ravussin

Clinical Research Faculty Publications

Purpose: Smaller lipid droplet morphology and GLUT 4 protein expression have been associated with greater muscle oxidative capacity and glucose uptake, respectively. The main purpose of this study was to determine the effect of an acute long-duration exercise bout on skeletal muscle lipid droplet morphology, GLUT4, perilipin 3, and perilipin 5 expressions. Methods: Twenty healthy men (age 24.0 ± 1.0 years, BMI 23.6 ± 0.4 kg/m2) were recruited for the study. The participants were subjected to an acute bout of exercise on a cycle ergometer at 50% VO2max until they reached a total energy expenditure of 650 kcal. The study …

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Body Shape Perception In Men And Women Without Obesity During Caloric Restriction: A Secondary Analysis From The Calerie Study, Maci M. Jacobson, Alexis M. Gardner, Camilla E. Handley, Michael W. Smith, William F. Christensen, Chad R. Hancock, Paule V. Joseph, Michael J. Larson, Corby K. Martin, James D. Lecheminant Dec 2023

Body Shape Perception In Men And Women Without Obesity During Caloric Restriction: A Secondary Analysis From The Calerie Study, Maci M. Jacobson, Alexis M. Gardner, Camilla E. Handley, Michael W. Smith, William F. Christensen, Chad R. Hancock, Paule V. Joseph, Michael J. Larson, Corby K. Martin, James D. Lecheminant

Clinical Research Faculty Publications

Objective: To examine body shape perception in 218 adults without obesity or history of eating disorders during caloric restriction (CR). Methods: Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) is a 2-year, randomized clinical trial using a 2:1 assignment (CR, 25% reduction in calories; Control, typical diet). For this secondary analysis, we examined perceived body shape using the Body Shape Questionnaire (BSQ). Analyses of BSQ scores are reported by group, over time, by sex, and by BMI. Data for body fat percentage, symptoms of depression, food cravings, maximal oxygen consumption, and stress were analyzed for their association …

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Protocol To Evaluate The Effectiveness And Cost-Effectiveness Of An Environmental Nutrition And Physical Activity Intervention In Nurseries (Nutrition And Physical Activity Self Assessment For Child Care - Nap Sacc Uk): A Multicentre Cluster Randomised Controlled Trial, Ruth Kipping, Miranda Pallan, Kim Hannam, Kate Willis, Alex Dobell, Chris Metcalfe, Russell Jago, Laura Johnson, Rebecca Langford, Corby K. Martin, William Hollingworth, Madeleine Cochrane, James White, Pete Blair, Zoi Toumpakari, Jodi Taylor, Dianne Ward, Laurence Moore, Tom Reid, Megan Pardoe, Liping Wen, Marie Murphy, Anne Martin, Stephanie Chambers, Sharon Anne Simpson Dec 2023

Protocol To Evaluate The Effectiveness And Cost-Effectiveness Of An Environmental Nutrition And Physical Activity Intervention In Nurseries (Nutrition And Physical Activity Self Assessment For Child Care - Nap Sacc Uk): A Multicentre Cluster Randomised Controlled Trial, Ruth Kipping, Miranda Pallan, Kim Hannam, Kate Willis, Alex Dobell, Chris Metcalfe, Russell Jago, Laura Johnson, Rebecca Langford, Corby K. Martin, William Hollingworth, Madeleine Cochrane, James White, Pete Blair, Zoi Toumpakari, Jodi Taylor, Dianne Ward, Laurence Moore, Tom Reid, Megan Pardoe, Liping Wen, Marie Murphy, Anne Martin, Stephanie Chambers, Sharon Anne Simpson

Clinical Research Faculty Publications

Background: One in seven UK children have obesity when starting school, with higher prevalence associated with deprivation. Most pre-school children do not meet UK recommendations for physical activity and nutrition. Formal childcare settings provide opportunities to deliver interventions to improve nutritional quality and physical activity to the majority of 3–4-year-olds. The nutrition and physical activity self-assessment for childcare (NAP SACC) intervention has demonstrated effectiveness in the USA with high acceptability in the UK. The study aims to evaluate the effectiveness and cost-effectiveness of the NAP SACC UK intervention to increase physical activity, reduce sedentary time and improve nutritional intake. Methods: …

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An Aerobic Exercise Intervention To Improve Metabolic Health Among People Living With Hiv With At-Risk Alcohol Use: The Alive-Ex Research Study Protocol, Liz Simon, Stefany D. Primeaux, Danielle E. Levitt, Brianna Bourgeois, Neil M. Johannsen, Adrianna Peters, Jameel Ahmed, Richard H. Marshall, Alexandra H. Fairchild, Tekeda F. Ferguson, Patricia E. Molina Dec 2023

An Aerobic Exercise Intervention To Improve Metabolic Health Among People Living With Hiv With At-Risk Alcohol Use: The Alive-Ex Research Study Protocol, Liz Simon, Stefany D. Primeaux, Danielle E. Levitt, Brianna Bourgeois, Neil M. Johannsen, Adrianna Peters, Jameel Ahmed, Richard H. Marshall, Alexandra H. Fairchild, Tekeda F. Ferguson, Patricia E. Molina

Clinical Research Faculty Publications

Background: Effective antiretroviral therapy (ART) in people living with HIV (PLWH) has improved life expectancy and increased risk of age-associated cardiometabolic comorbidities. At-risk alcohol use is more frequent among PLWH and increases the risk of health challenges. PLWH with at-risk alcohol use are more likely to meet criteria for prediabetes/diabetes and this is associated with impaired whole-body glucose-insulin dynamics. Methods: The Alcohol & Metabolic Comorbidities in PLWH: Evidence Driven Interventions Study (ALIVE-Ex Study, NCT03299205) is a longitudinal, prospective, interventional study to determine the effects of an aerobic exercise protocol on improving dysglycemia among PLWH with at-risk alcohol use. The intervention …

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An Examination Of The Relationships Between The Neighborhood Social Environment, Adiposity, And Cardiometabolic Disease Risk In Adolescence: A Cross-Sectional Study, Kara D. Denstel, Robbie A. Beyl, Denise M. Danos, Maura M. Kepper, Amanda E. Staiano, Katherine T. Theall, Tung Sung Tseng, Stephanie T. Broyles Dec 2023

An Examination Of The Relationships Between The Neighborhood Social Environment, Adiposity, And Cardiometabolic Disease Risk In Adolescence: A Cross-Sectional Study, Kara D. Denstel, Robbie A. Beyl, Denise M. Danos, Maura M. Kepper, Amanda E. Staiano, Katherine T. Theall, Tung Sung Tseng, Stephanie T. Broyles

Population and Public Health Science Faculty Publications

Background: Disadvantaged neighborhood environments are a source of chronic stress which undermines optimal adolescent health. This study investigated relationships between the neighborhood social environment, specifically, chronic stress exposures, adiposity, and cardiometabolic disease risk factors among 288 Louisiana adolescents aged 10 to 16 years. Methods: This cross-sectional study utilized baseline data from the Translational Investigation of Growth and Everyday Routines in Kids (TIGER Kids) study. Adolescent data were obtained using self-reported questionnaires (demographics and perceived neighborhood disorder), anthropometry, body imaging, and a blood draw while objective neighborhood data for the concentrated disadvantage index were acquired from the 2016 American Community Survey …

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Adolescent Diet Quality, Cardiometabolic Risk, And Adiposity: A Prospective Cohort, Kathy Hu, Alyssa M. Button, Claire M. Tate, Chelsea L. Kracht, Catherine M. Champagne, Amanda E. Staiano Dec 2023

Adolescent Diet Quality, Cardiometabolic Risk, And Adiposity: A Prospective Cohort, Kathy Hu, Alyssa M. Button, Claire M. Tate, Chelsea L. Kracht, Catherine M. Champagne, Amanda E. Staiano

Population and Public Health Science Faculty Publications

Objective: Examine the prospective association among diet with adolescent cardiometabolic risk (CMR) and anthropometrics. Methods: Secondary analysis of an observational study of adolescents aged 10–16 years. Twenty-four-hour food recalls were used to calculate Healthy Eating Index-2015 (HEI-2015) scores. Anthropometrics were assessed using magnetic resonance imaging, dual-energy x-ray absorptiometry, and height/weight measurements. CMR included mean arterial pressure, homeostatic model assessment for insulin resistance, high-density lipoprotein cholesterol, and triglycerides. Associations between HEI-2015 score at baseline with follow-up adiposity and CMR were examined using regression models. Results: A total of 192 adolescents were included. Baseline HEI-2015 scores were inversely associated with follow-up total …

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Amplifying Support For Physical Activity: The National Strategy On Hunger, Nutrition, And Health, Peter T. Katzmarzyk, John M. Jakicic, Russell R. Pate, Katrina L. Piercy, Laurie P. Whitsel Dec 2023

Amplifying Support For Physical Activity: The National Strategy On Hunger, Nutrition, And Health, Peter T. Katzmarzyk, John M. Jakicic, Russell R. Pate, Katrina L. Piercy, Laurie P. Whitsel

Population and Public Health Science Faculty Publications

No abstract provided.

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Adherence To Recess Guidelines In The United States Using Nationally Representative Data: Implications For Future Surveillance Efforts, Kimberly A. Clevenger, Genevieve F. Dunton, Peter T. Katzmarzyk, Karin A. Pfeiffer, David Berrigan Dec 2023

Adherence To Recess Guidelines In The United States Using Nationally Representative Data: Implications For Future Surveillance Efforts, Kimberly A. Clevenger, Genevieve F. Dunton, Peter T. Katzmarzyk, Karin A. Pfeiffer, David Berrigan

Population and Public Health Science Faculty Publications

BACKGROUND: National adherence to the recess recommendations of the Centers for Disease Control and Prevention (CDC) has not been comprehensively studied in the United States. METHODS: Data from 6 nationally representative data sets over the last decade (Classification of Laws Associated with School Students, Early Childhood Longitudinal Study, National Health and Nutrition Examination Survey, National Youth Fitness Survey, School Health Policies and Practices Survey, and the School Nutrition and Meal Cost Study) provided estimates for adherence to CDC recess guidelines. RESULTS: While approximately 65-80% of elementary school-children receive the recommended 20+ minutes of daily recess according to parent-, principal-, and …

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Ketogenic Propensity Is Differentially Related To Lipid-Induced Hepatic And Peripheral Insulin Resistance, J. T. Mey, B. Vandagmansar, W. S. Dantas, K. P. Belmont, C. L. Axelrod, J. P. Kirwan Dec 2023

Ketogenic Propensity Is Differentially Related To Lipid-Induced Hepatic And Peripheral Insulin Resistance, J. T. Mey, B. Vandagmansar, W. S. Dantas, K. P. Belmont, C. L. Axelrod, J. P. Kirwan

Division of Basic Science Faculty Publications

Aim: Determine the ketogenic response (β-hydroxybutyrate, a surrogate of hepatic ketogenesis) to a controlled lipid overload in humans. Methods: In total, nineteen young, healthy adults (age: 28.4 ± 1.7 years; BMI: 22.7 ± 0.3 kg/m2) received either a 12 h overnight lipid infusion or saline in a randomized, crossover design. Plasma ketones and inflammatory markers were quantified by colorimetric and multiplex assays. Hepatic and peripheral insulin sensitivity was assessed by the hyperinsulinemic–euglycemic clamp. Skeletal muscle biopsies were obtained to quantify gene expression related to ketone body metabolism and inflammation. Results: By design, the lipid overload-induced hepatic (50%, p < 0.001) and peripheral insulin resistance (73%, p < 0.01) in healthy adults. Ketones increased with hyperlipidemia and were subsequently reduced with hyperinsulinemia during the clamp procedure (Saline: Basal = 0.22 mM, Insulin = 0.07 mM; Lipid: Basal = 0.78 mM, Insulin = 0.51 mM; 2-way ANOVA: Lipid p < 0.001, Insulin p < 0.001, Interaction p = 0.07). In the saline control condition, ketones did not correlate with hepatic or peripheral insulin sensitivity. Conversely, in the lipid condition, ketones were positively correlated with hepatic insulin sensitivity (r = 0.59, p < 0.01), but inversely related to peripheral insulin sensitivity (r = −0.64, p < 0.01). Hyperlipidemia increased plasma inflammatory markers, but did not impact skeletal muscle inflammatory gene expression. Gene expression related to ketone and fatty acid metabolism in skeletal muscle increased in response to hyperlipidemia. Conclusion: This work provides important insight into the role of ketones in human health and suggests that ketone body metabolism is altered at the onset of lipid-induced insulin resistance.

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Weight-Independent Effects Of Roux-En-Y Gastric Bypass Surgery On Remission Of Nonalcoholic Fatty Liver Disease In Mice, Christopher L. Axelrod, Ingeborg Langohr, Wagner S. Dantas, Elizabeth C. Heintz, Bolormaa Vandanmagsar, Shengping Yang, Elizabeth R.M. Zunica, R. Leigh Townsend, Vance L. Albaugh, Hans Rudolf Berthoud, John P. Kirwan Dec 2023

Weight-Independent Effects Of Roux-En-Y Gastric Bypass Surgery On Remission Of Nonalcoholic Fatty Liver Disease In Mice, Christopher L. Axelrod, Ingeborg Langohr, Wagner S. Dantas, Elizabeth C. Heintz, Bolormaa Vandanmagsar, Shengping Yang, Elizabeth R.M. Zunica, R. Leigh Townsend, Vance L. Albaugh, Hans Rudolf Berthoud, John P. Kirwan

Division of Basic Science Faculty Publications

Objective: Obesity is a driver of non-alcoholic fatty liver disease (NAFLD), and interventions that decrease body weight, such as bariatric surgery and/or calorie restriction (CR), may serve as effective therapies. This study compared the effects of Roux-en-Y gastric bypass surgery (RYGB) and CR on hepatic function in mice with obesity and NAFLD. Methods: C57BL/6J mice were fed a high-fat diet to promote obesity. At 16 weeks of age, mice were randomized to sham surgery (sham), RYGB, or CR weight matched to RYGB (WM). Body weight/composition, food intake, and energy expenditure (EE) were measured throughout treatment. Liver histopathology was evaluated from …

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Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review, Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel Dec 2023

Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review, Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel

Clinical Research Faculty Publications

Background: Monogenic insulin resistance (IR) includes lipodystrophy and disorders of insulin signalling. We sought to assess the effects of interventions in monogenic IR, stratified by genetic aetiology. Methods: Systematic review using PubMed, MEDLINE and Embase (1 January 1987 to 23 June 2021). Studies reporting individual-level effects of pharmacologic and/or surgical interventions in monogenic IR were eligible. Individual data were extracted and duplicates were removed. Outcomes were analysed for each gene and intervention, and in aggregate for partial, generalised and all lipodystrophy. Results: 10 non-randomised experimental studies, 8 case series, and 23 case reports meet inclusion criteria, all rated as having …

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Participant Characteristics In The Prevention Of Gestational Diabetes As Evidence For Precision Medicine: A Systematic Review And Meta-Analysis, Siew Lim, Siew Lim, Wubet Worku Takele, Kimberly K. Vesco, Leanne M. Redman, Wesley Hannah, Wesley Hannah, Maxine P. Bonham, Mingling Chen, Sian C. Chivers, Andrea J. Fawcett, Andrea J. Fawcett, Jessica A. Grieger, Nahal Habibi, Gloria K.W. Leung, Kai Liu, Eskedar Getie Mekonnen, Maleesa Pathirana, Alejandra Quinteros, Rachael Taylor, Gebresilasea G. Ukke, Gebresilasea G. Ukke, Shao J. Zhou, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds Dec 2023

Participant Characteristics In The Prevention Of Gestational Diabetes As Evidence For Precision Medicine: A Systematic Review And Meta-Analysis, Siew Lim, Siew Lim, Wubet Worku Takele, Kimberly K. Vesco, Leanne M. Redman, Wesley Hannah, Wesley Hannah, Maxine P. Bonham, Mingling Chen, Sian C. Chivers, Andrea J. Fawcett, Andrea J. Fawcett, Jessica A. Grieger, Nahal Habibi, Gloria K.W. Leung, Kai Liu, Eskedar Getie Mekonnen, Maleesa Pathirana, Alejandra Quinteros, Rachael Taylor, Gebresilasea G. Ukke, Gebresilasea G. Ukke, Shao J. Zhou, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds

Clinical Research Faculty Publications

Background: Precision prevention involves using the unique characteristics of a particular group to determine their responses to preventive interventions. This study aimed to systematically evaluate the participant characteristics associated with responses to interventions in gestational diabetes mellitus (GDM) prevention. Methods: We searched MEDLINE, EMBASE, and Pubmed to identify lifestyle (diet, physical activity, or both), metformin, myoinositol/inositol and probiotics interventions of GDM prevention published up to May 24, 2022. Results: From 10347 studies, 116 studies (n = 40940 women) are included. Physical activity results in greater GDM reduction in participants with a normal body mass index (BMI) at baseline compared to …

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Precision Gestational Diabetes Treatment: A Systematic Review And Meta-Analyses, Jamie L. Benham, Véronique Gingras, Niamh Maire Mclennan, Jasper Most, Jennifer M. Yamamoto, Catherine E. Aiken, Susan E. Ozanne, Susan E. Ozanne, Rebecca M. Reynolds, Rebecca M. Reynolds, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs Dec 2023

Precision Gestational Diabetes Treatment: A Systematic Review And Meta-Analyses, Jamie L. Benham, Véronique Gingras, Niamh Maire Mclennan, Jasper Most, Jennifer M. Yamamoto, Catherine E. Aiken, Susan E. Ozanne, Susan E. Ozanne, Rebecca M. Reynolds, Rebecca M. Reynolds, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs

Clinical Research Faculty Publications

Background: Gestational Diabetes Mellitus (GDM) affects approximately 1 in 7 pregnancies globally. It is associated with short- and long-term risks for both mother and baby. Therefore, optimizing treatment to effectively treat the condition has wide-ranging beneficial effects. However, despite the known heterogeneity in GDM, treatment guidelines and approaches are generally standardized. We hypothesized that a precision medicine approach could be a tool for risk-stratification of women to streamline successful GDM management. With the relatively short timeframe available to treat GDM, commencing effective therapy earlier, with more rapid normalization of hyperglycaemia, could have benefits for both mother and fetus. Methods: We …

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Treatment Effect Heterogeneity Following Type 2 Diabetes Treatment With Glp1-Receptor Agonists And Sglt2-Inhibitors: A Systematic Review, Katherine G. Young, Eram Haider Mcinnes, Robert J. Massey, Anna R. Kahkoska, Scott J. Pilla, Sridharan Raghavan, Maggie A. Stanislawski, Deirdre K. Tobias, Andrew P. Mcgovern, Andrew P. Mcgovern, Adem Y. Dawed, Angus G. Jones, Ewan R. Pearson, Ewan R. Pearson, John M. Dennis, John M. Dennis, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng Dec 2023

Treatment Effect Heterogeneity Following Type 2 Diabetes Treatment With Glp1-Receptor Agonists And Sglt2-Inhibitors: A Systematic Review, Katherine G. Young, Eram Haider Mcinnes, Robert J. Massey, Anna R. Kahkoska, Scott J. Pilla, Sridharan Raghavan, Maggie A. Stanislawski, Deirdre K. Tobias, Andrew P. Mcgovern, Andrew P. Mcgovern, Adem Y. Dawed, Angus G. Jones, Ewan R. Pearson, Ewan R. Pearson, John M. Dennis, John M. Dennis, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng

Clinical Research Faculty Publications

Background: A precision medicine approach in type 2 diabetes requires the identification of clinical and biological features that are reproducibly associated with differences in clinical outcomes with specific anti-hyperglycaemic therapies. Robust evidence of such treatment effect heterogeneity could support more individualized clinical decisions on optimal type 2 diabetes therapy. Methods: We performed a pre-registered systematic review of meta-analysis studies, randomized control trials, and observational studies evaluating clinical and biological features associated with heterogenous treatment effects for SGLT2-inhibitor and GLP1-receptor agonist therapies, considering glycaemic, cardiovascular, and renal outcomes. After screening 5,686 studies, we included 101 studies of SGLT2-inhibitors and 75 studies …

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The Partner-An Underutilized Facilitator To Support Healthy Gestational Weight Gain, Joshua R. Sparks, Suzanne Phelan, Kimberly L. Drews, Leanne M. Redman Dec 2023

The Partner-An Underutilized Facilitator To Support Healthy Gestational Weight Gain, Joshua R. Sparks, Suzanne Phelan, Kimberly L. Drews, Leanne M. Redman

Clinical Research Faculty Publications

No abstract provided.

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Increased Lipogenesis Is Important For Hexavalent Chromium-Transformed Lung Cells And Xenograft Tumor Growth, James T.F. Wise, Kazuya Kondo Dec 2023

Increased Lipogenesis Is Important For Hexavalent Chromium-Transformed Lung Cells And Xenograft Tumor Growth, James T.F. Wise, Kazuya Kondo

Faculty Publications

Hexavalent chromium, Cr(VI), is a known carcinogen and environmental health concern. It has been established that reactive oxygen species, genomic instability, and DNA damage repair deficiency are important contributors to the Cr(VI)-induced carcinogenesis mechanism. However, some hallmarks of cancer remain under-researched regarding the mechanism behind Cr(VI)-induced carcinogenesis. Increased lipogenesis is important to carcinogenesis and tumorigenesis in multiple types of cancers, yet the role increased lipogenesis has in Cr(VI) carcinogenesis is unclear. We report here that Cr(VI)-induced transformation of three human lung cell lines (BEAS-2B, BEP2D, and WTHBF-6) resulted in increased lipogenesis (palmitic acid levels), and Cr(VI)-transformed cells had an increased …

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Painted Playgrounds For Preschoolers’ Physical Activity And Fundamental Motor Skill Improvement: A Randomized Controlled Pilot Trial Of Effectiveness, E. Kipling Webster, Maura M. Kepper, Sanjoy Saha, Robbie A. Beyl, Chelsea L. Kracht, Jessica St Romain, Amanda E. Staiano Dec 2023

Painted Playgrounds For Preschoolers’ Physical Activity And Fundamental Motor Skill Improvement: A Randomized Controlled Pilot Trial Of Effectiveness, E. Kipling Webster, Maura M. Kepper, Sanjoy Saha, Robbie A. Beyl, Chelsea L. Kracht, Jessica St Romain, Amanda E. Staiano

Population and Public Health Science Faculty Publications

Background: Preschool children are not meeting recommended levels of physical activity (PA) nor are they proficient in fundamental motor skills (FMS), which are the foundation for PA. As such, interventions are needed to increase PA and FMS in young children. This trial examined the effects of an environmental (“painted playgrounds”) and capacity-building (written toolkit) intervention on child FMS, PA, and sedentary behavior at early childhood education (ECE) centers and examined feasibility. Methods: In a randomized controlled trial, four ECE centers were randomly assigned to an intervention group or wait-list control. For intervention centers, stencils were spray painted adjacent to playgrounds …

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Super Parents: Preliminary Findings Of A Group-Based Parenting Intervention, Jens E. Jespersen, Cara D. Bosler, Ruth S. Slocum, Jennifer Hays-Grudo, Jerry Root, Laura Hubbs-Tait, Amanda Sheffield Morris Dec 2023

Super Parents: Preliminary Findings Of A Group-Based Parenting Intervention, Jens E. Jespersen, Cara D. Bosler, Ruth S. Slocum, Jennifer Hays-Grudo, Jerry Root, Laura Hubbs-Tait, Amanda Sheffield Morris

Journal of Human Sciences and Extension

Super Parents is a group-based, Extension-led parenting program developed to enhance the parent-child relationship. Implemented by trained Head Start staff using the train-the-trainer model, this effort is achieved by teaching positive parenting practices, increasing parents’ knowledge of child development, instructing parents in activities and exercises for enhancing their child’s executive function skills, and encouraging the use of mindfulness techniques in parenting. The specific aims of our study were to evaluate the program's effectiveness among parents of young children ages 0 to 5 by examining changes in parenting attitudes, mindfulness, executive function, parenting efficacy, stress, and child behavior. Through the use …

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Impact Of Prolonged Professional Development On Teachers’ Confidence In Using Inquiry-Based Learning In The Classroom, Kasey Harmon, Taylor Ruth, Bryan Reiling, Nathan W. Conner, Christopher T. Stripling Dec 2023

Impact Of Prolonged Professional Development On Teachers’ Confidence In Using Inquiry-Based Learning In The Classroom, Kasey Harmon, Taylor Ruth, Bryan Reiling, Nathan W. Conner, Christopher T. Stripling

Journal of Human Sciences and Extension

Professional development (PD) programs for science and agriculture teachers designed around the inquiry-based learning (IBL) teaching strategy could help to improve science proficiency amongst our high school students. PD that continues over a longer period of time is more effective than short-term workshops. The purpose of this study was to explore the impact of a prolonged PD program on teachers’ confidence in using IBL strategies for teaching animal sciences content. The following research questions guided this study: RQ1: What were participants’ perceptions of a prolonged PD program? and RQ2: How did the prolonged PD program influence the participants’ confidence in …

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Educational Interests And Information-Seeking Behaviors Of Utah Residents, Amanda D. Ali, Lendel K. Narine Dec 2023

Educational Interests And Information-Seeking Behaviors Of Utah Residents, Amanda D. Ali, Lendel K. Narine

Journal of Human Sciences and Extension

With a limited body of literature examining residents’ preferences for Extension topic areas, this brief report examined the educational interests of Utah residents. It explores opportunities for future programming based on residents’ preferences for topic areas and their information-seeking behaviors. Data were gathered from Utah residents in May 2021 via an online Qualtrics survey (n = 668). Results showed the topics of highest interest to Utah residents were strengthening family relationships, emergency preparedness, mental health, food storage, and healthy couples’ relationships. Residents’ information-seeking behaviors were somewhat consistent with their interests; residents searched most frequently for information on mental health, strengthening …

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Barriers To Policy, Systems, And Environment Work: Using Community Engagement As A Tool In Snap-Ed’S Multi-Level Comprehensive Programming, Cristian Meier, Casey Coombs, Amria Farnsworth, Lacee Jimenez, Heidi Leblanc Dec 2023

Barriers To Policy, Systems, And Environment Work: Using Community Engagement As A Tool In Snap-Ed’S Multi-Level Comprehensive Programming, Cristian Meier, Casey Coombs, Amria Farnsworth, Lacee Jimenez, Heidi Leblanc

Journal of Human Sciences and Extension

Implementing policy, system, and environmental (PSE) changes has several well-known challenges that have been documented in Supplemental Nutrition Assistance Program Education’s (SNAP-Ed) comprehensive approach to obesity prevention and reduction. The purpose of the current study was to explore the use of community engagement (CE) as a strategy to address the common challenges experienced in implementing a multi-component community-based program. Phone interviews (N = 7) were conducted with SNAP-Ed educators in Utah using semi-structured interviews. Emergent themes were identified as transcripts were coded independently by two researchers until a high level of agreement was achieved. Four themes emerged from the interviews: …

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Determining The Health Literacy Skills Of Extension Audiences In Maryland, Beverly Jackey, Heejung Song, Lisa Mccoy, Virginia Brown Dec 2023

Determining The Health Literacy Skills Of Extension Audiences In Maryland, Beverly Jackey, Heejung Song, Lisa Mccoy, Virginia Brown

Journal of Human Sciences and Extension

Strong health literacy skills empower people to make informed health decisions, especially those with chronic health conditions striving for positive health outcomes. Half of all people living in Maryland report having at least one chronic disease. Research examining the health literacy of Marylanders is limited. This paper reports how establishing a baseline for health literacy levels of Marylanders can identify major factors affecting the health literacy skills of Extension audiences and lays the important groundwork to develop Extension programs and explore the best delivery methods tailored to the needs of subpopulations. Using the Newest Vital Sign, a …

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An Analysis Of Community Health Workers And Its Prospect As A Profession, Medea Sanabria Dec 2023

An Analysis Of Community Health Workers And Its Prospect As A Profession, Medea Sanabria

Undergraduate Theses and Capstone Projects

This literature paper reviews the purpose of community health workers, how they impact community access to health systems and services, and the professional prospects for this career path. In this paper, I discuss how community health workers integrate the main pillars of liberation psychology, specifically the concepts of problematization, acompañamiento, and praxis into their day-to-day responsibilities. The goal of community health workers is to help people navigate complex health systems, raise awareness about health-related topics, organize interventions, and advocate for patients to receive health services. Throughout this literature paper, I analyzed the position of community health workers and contemplated …

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Beyond The Plate: Leisure Studies As A Recipe For Food Justice, Julia M. Montano Dec 2023

Beyond The Plate: Leisure Studies As A Recipe For Food Justice, Julia M. Montano

Undergraduate Honors Theses

To address the issues that have been derived from the dominant forces in our food systems, movements such as food justice strive to find solutions through decolonization and addressing barriers to accessing healthy, affordable and culturally representative food. One group of individuals that are heavily involved in, and impacted by, food justice are college students. This study seeks to explore the extent to which college students’ involvement in food justice is shaped by their free time. With this research, I strive to bring in the voices of college students, while also bridging a gap in the field by bringing leisure …

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