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2023

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Effect Of Fertilisation With Macro And Micronutrients On The Mineral Content Of Leucaena Leucocephala, S. Camacaro Aug 2023

Effect Of Fertilisation With Macro And Micronutrients On The Mineral Content Of Leucaena Leucocephala, S. Camacaro

IGC Proceedings (1977-2023)

The Venezuelan cattle industry has been developed in areas with soil limitations, causing a negative impact on animal production, since the pastures are of medium to low quality and quick maturation (Chacón, 1996). On the other hand, forage legumes have been introduced to improve the nutritive value of the biomass on offer. Growing interest has been shown in Leucaena leucocephala in recent years due to its multiple benefits (Duguma et al., 1988). However the use of varieties not adapted to acid soils can be a problem, largely due their low tolerance to the toxicity of the aluminium and to …


Effect Of Mineral Fertiliser Levels On The Yield Quality Of Perennial Ryegrass, S. R. Bumane, Aleksandr Adamovich Aug 2023

Effect Of Mineral Fertiliser Levels On The Yield Quality Of Perennial Ryegrass, S. R. Bumane, Aleksandr Adamovich

IGC Proceedings (1977-2023)

Perennial ryegrass is a short-lived bunch-grass with shallow root system. The plant is nutritious and palatable and stands up to hard grazing. It will not do well under poor conditions, where fertility or rainfall is low. Perennial ryegrass is a major component in different seed mixtures that are used for grassland management and forage production. This plant is the predominant component in nearly all pasture mixtures, with perennial ryegrass and white or red clover forming the basis for permanent pasture for dairy production and cattle. This grass species plays an important role in grassland productivity and forage quality. Ryegrass requires …


Combinations Of Nitrogen And Sulphur For Signal Grass Yield, F. A. Monteiro, C. P. Silveira Aug 2023

Combinations Of Nitrogen And Sulphur For Signal Grass Yield, F. A. Monteiro, C. P. Silveira

IGC Proceedings (1977-2023)

Signal grass (Brachiaria decumbens) is grown in Brazilian pastures, and the increase in forage yield of such pastures is achieved by fertilization. Nitrogen (N) is the nutrient mostly demanded for increasing grass productivity, and its utilization creates a demand for other nutrients, such as sulphur (S). These two nutrients are well related in plant metabolism, but the S nutrition of signal grass must be better understood. The use of a fractional factorial makes possible the study of several rates of these two nutrients, that combined with the response surface methodology allows anyone to find out the responses to …


Increase In Forage Maize Production By Bacterial Fertilisers, D. Egamberdiyeva, G. Hoflich Aug 2023

Increase In Forage Maize Production By Bacterial Fertilisers, D. Egamberdiyeva, G. Hoflich

IGC Proceedings (1977-2023)

Farmers in many countries value green material generated from maize as a high quality forage. Its inclusion in dairy cow diets can improve forage intake, increase animal performance and has the potential to reduce production costs (Phipps, 1994). Restrictions on the use of chemical fertilisers and a renewed interest in organic sustainable farming systems in general, has restored attention to crop rotations The increase of maize production using bacterial fertilisers also gives alternative ways to reduce chemical fertilisers in forage production. Increased uptake of nutrients such as N, P, and K and crop yield was reported with rhizobacteria (Lazarovits & …


The Effect Of Nitrogen Fixation And Plant Species On Ammonium And Amino Acids Soil Contents, F. Lesuffleur, S. Diquélou, A. Bré, J. B. Cliquet Aug 2023

The Effect Of Nitrogen Fixation And Plant Species On Ammonium And Amino Acids Soil Contents, F. Lesuffleur, S. Diquélou, A. Bré, J. B. Cliquet

IGC Proceedings (1977-2023)

Grass and legume intercropping systems, particularly ryegrass-clover mixed cultures, increase grasslands productivity, due to the clover nitrogen (N) fixation and to the transfer of part it to the companion grass. The objective of this experiment was to determine if N fixation and plant species could modify ammonium and amino acids soil contents.


Breastfeeding Education Of Medical Students And Resident Physicians, Kathleen E.H. Douangchak D.O. Aug 2023

Breastfeeding Education Of Medical Students And Resident Physicians, Kathleen E.H. Douangchak D.O.

Intellectus

Breastfeeding is widely recognized for its medical and neurodevelopmental benefits, leading to the American Academy of Pediatrics (AAP) recommending exclusive breastfeeding for the first 6 months of an infant’s life with continuation through 2 years of age and beyond.1 However, this literature review finds that despite the 2022 update to the AAP’s recommendations, education on breastfeeding for physicians-in-training is inadequate. Though interventions have been shown to increase the breastfeeding knowledge and confidence of physicians, more research is needed to evaluate the efficacy of educational interventions. This paper emphasizes the urgency of implementing comprehensive interventions that address the gaps in breastfeeding …


Integration Of A Culturally Appropriate Method Of Delivering Health Information In A Non-Clinical Setting, Nancy Nguyen, Merett Saad, Andrew Vo, Alejandro Castaneda, Uriel Martinez, Jonathan Do, Kevin Trembley, Imran Javaid, Hargurbir Alhuwalia, Jaskirat Malhi, Carolina Quezada M.D., Joy H. Lewis D.O., Phd Aug 2023

Integration Of A Culturally Appropriate Method Of Delivering Health Information In A Non-Clinical Setting, Nancy Nguyen, Merett Saad, Andrew Vo, Alejandro Castaneda, Uriel Martinez, Jonathan Do, Kevin Trembley, Imran Javaid, Hargurbir Alhuwalia, Jaskirat Malhi, Carolina Quezada M.D., Joy H. Lewis D.O., Phd

Intellectus

Context:

A.T. Still University School of Osteopathic Medicine in Arizona (ATSU-SOMA) has an established partnership with Family HealthCare Network (FHCN). Initial meetings with the local community outreach department identified that a substantial majority of the Hispanic population served by this health center may lack access to health education. In particular, Spanish-speaking patients at the health center may face language barriers that impair the transfer of health education between the providers, patients, and their families.

Objective:

The purpose of this study was to provide health educational presentations in Spanish in order to improve health knowledge relating to women’s and children’s health. …


Modelling Urine Nitrogen Production And Leaching Losses For Pasture-Based Dairying Systems, I. M. Brookes, D. J. Horne Aug 2023

Modelling Urine Nitrogen Production And Leaching Losses For Pasture-Based Dairying Systems, I. M. Brookes, D. J. Horne

IGC Proceedings (1977-2023)

Urine from dairy cattle grazing pastures with high crude protein (CP) concentrations is a major source of N lost in drainage water from New Zealand farms. This paper provides predictions of urinary N leaching losses for a range of stocking rates and levels of supplementation.


Cap Reform And Nitrate Restrictions: Implications For Irish Grass Based Dairy Production Systems, Anne Marie Butler, M. Wallace, P. Dillon Aug 2023

Cap Reform And Nitrate Restrictions: Implications For Irish Grass Based Dairy Production Systems, Anne Marie Butler, M. Wallace, P. Dillon

IGC Proceedings (1977-2023)

The benefit of a systems approach to analysing production situations has long been recognised in agricultural research. The development and application of production-oriented dairy models offer tremendous capabilities for both encompassing the realities faced by producers while also considering the adaptation possibilities available to them in light of internal and external forces of change. This farm level dairy model represents one such approach. The objectives of the study were: (1) to develop a comprehensive farm-level model of Irish milk production systems and (2) to apply the model to identify optimal adaptation strategies of dairy farmers within the context of European …


Sustainable Grazing On Saline Land In Western Australia - Multidisciplinary Research Linking Producers And Scientists, Hayley C. Norman, D. G. Masters, M. G. Wilmot, A. J. Rintoul, R. Silberstein, E. Lefroy, T. York Aug 2023

Sustainable Grazing On Saline Land In Western Australia - Multidisciplinary Research Linking Producers And Scientists, Hayley C. Norman, D. G. Masters, M. G. Wilmot, A. J. Rintoul, R. Silberstein, E. Lefroy, T. York

IGC Proceedings (1977-2023)

Dryland salinity is one of the most critical environmental issues challenging Western Australian farmers. Currently 10% of the cropping zone (1.8 million ha) is salt-affected and this is predicted to increase dramatically in the next 50 years (NLWRA, 2001). Animals grazing saline pasture systems represent the most likely large-scale opportunity for economic return from saline land in the short to medium term. To date, few farmers have invested in large-scale revegetation of saline land as the economic return from grazing has not been perceived to cover costs. Furthermore other benefits of saltland pasture systems, such as biodiversity, water use and …


Anti-Inflammatory Dietary Patterns Effect On Cancer Risk And Mortality: A Review In Cancer, Mathew Kramm Iv, Carrie Daniel-Macdougall Aug 2023

Anti-Inflammatory Dietary Patterns Effect On Cancer Risk And Mortality: A Review In Cancer, Mathew Kramm Iv, Carrie Daniel-Macdougall

Summer Experience 2023

No abstract provided.


Nutrient Supplementation For Pre- And Post Acl Operation & Rehabilitation In Female Basketball Players, Mackenzie Steele, Joshua Munoz Aug 2023

Nutrient Supplementation For Pre- And Post Acl Operation & Rehabilitation In Female Basketball Players, Mackenzie Steele, Joshua Munoz

Department of Nutrition Student Projects

Understanding how nutrition and dietary protocols can help female athletes in the process of “returning to sport” after an anterior cruciate ligament (ACL) repair surgery should be discussed amongst interprofessional post-operational care teams. Amongst athletes, female counterparts experience ACL injuries at a higher incidence rate than males, this is due to a variety of biological factors while returning to sport at a lower rate. Due to this, it is important to analyze and evaluate the data available from sports journals on the effects diet and supplements may have on the musculoskeletal system. ACL grafts are often taken from a donating …


Enhancing Long-Term Outcomes: Implementing Community Engaged Research To Augment Substance Use Disorder Treatment, Kevin M. Quinn Aug 2023

Enhancing Long-Term Outcomes: Implementing Community Engaged Research To Augment Substance Use Disorder Treatment, Kevin M. Quinn

Masters Theses

The Universal Evaluation Tool is an intuitive self-assessment instrument to enhance long-term treatment outcomes for Guiding Light’s residential addiction rehabilitation program. Designed as a versatile method for collecting primary data, the Universal Evaluation Tool can be administered to clients at any point during the recovery program (i.e., intake to discharge). The data collected from the survey can be used as a framework to guide treatment decisions, develop personalized care plans, offer insight into a client’s progress, and collect baseline data (e.g., sociodemographic characteristics) on a treatment population for use in grant applications.

A pilot study to generate preliminary data was …


"Journal Of Dietetic Education" Takes Off, University Of Dayton. School Of Education And Health Sciences Aug 2023

"Journal Of Dietetic Education" Takes Off, University Of Dayton. School Of Education And Health Sciences

School of Education and Health Sciences Blog Archive

Filling a gap in scholarly research, a new journal led by UD and Miami faculty members uncovers the latest knowledge in dietetics education.


Examining Perspectives Of New England Farmers Markets, Nicholas Gosling Aug 2023

Examining Perspectives Of New England Farmers Markets, Nicholas Gosling

UNH Today Archive

No abstract provided.


Investigating Transcriptional Anomalies During Persistence In Chlamydia Trachomatis, Nathan D. Hatch Aug 2023

Investigating Transcriptional Anomalies During Persistence In Chlamydia Trachomatis, Nathan D. Hatch

Theses & Dissertations

Chlamydia trachomatis (Ctr) is the leading cause of bacterial sexually transmitted infections. Ctr, a Gram-negative, obligate intracellular bacterium, develops within a membrane-bound vacuole termed an inclusion. This protective, nutrient rich, intracellular environment has allowed Ctr to undergo extensive reductive evolution – resulting in a streamlined genome of approximately 1 Mbp and the loss or fragmentation of several biosynthetic pathways, including the ability to synthesize tryptophan (Trp) de novo. During infection, the host immune system releases the cytokine IFNγ. Upon binding to a host cell, IFNγ stimulates the expression of indoleamine-2,3-dioxygenase, an enzyme capable of catabolizing cytosolic Trp, thereby starving …


Occupational Barriers In Attendance Of Diabetes Prevention Programs In Adults Of Low Socioeconomic Status, Kendra Green, Amy Lyons-Brown Aug 2023

Occupational Barriers In Attendance Of Diabetes Prevention Programs In Adults Of Low Socioeconomic Status, Kendra Green, Amy Lyons-Brown

Summer 2023 Virtual OTD Capstone Symposium

The purpose of this project was to meet the needs of adults of low socioeconomic status that are at risk for developing diabetes due to multiple occupational barriers through evidence-based interventions developed by Occupational Therapists. Reflecting on current literature on the social determinants of health can help clients achieve a better quality of life. It addressed the specific barriers in an individual’s lifestyle and community resources faced daily in occupations such as managing finances, shopping, sleeping, cooking, and eating healthier, along with utilizing physical activity to prevent diabetes. OT is underutilized in this area even though the expertise is needed …


A Quantification Of The Metabolic Demand Wrought By Explosive Ordinance Disposal Load Carriage, Gage Cousineau Aug 2023

A Quantification Of The Metabolic Demand Wrought By Explosive Ordinance Disposal Load Carriage, Gage Cousineau

Online Theses and Dissertations

In the last 7 years, there have been landmark studies concerning Explosive Ordinance Disposal (EOD) load carriage. These studies (Bach et al., 2017; Wu et al., 2022) have worked to quantify the ability of an operator to work while encumbered by EOD personal protective equipment (PPE), but have not evaluated possible sources of mitigation for the increased demand. Intuitively, it seems that greater levels of fitness would modify the degree of increased demand an operator may acquire during EOD load carriage. The current study seeks to illuminate relationships between strength, power, and/or endurance and EOD load carriage performance. Recreationally trained …


Effects Of Plyometric- And Cycle-Based High-Intensity Interval Training On Body Composition, Aerobic Capacity, And Muscle Function In Young Females: A Field-Based Group Fitness Assessment, A. J. Holmes, M. T. Stratton, A. R. Bailly, J. S. Gottschall, Y. Feito, P. L. Ha, A. Lavigne, K. Persaud, H. L. Gagnon, A. Krueger, A. Modjeski, T. A. Esmat, L. N. Harper, T. A. Vandusseldorp, Garrett Hester Aug 2023

Effects Of Plyometric- And Cycle-Based High-Intensity Interval Training On Body Composition, Aerobic Capacity, And Muscle Function In Young Females: A Field-Based Group Fitness Assessment, A. J. Holmes, M. T. Stratton, A. R. Bailly, J. S. Gottschall, Y. Feito, P. L. Ha, A. Lavigne, K. Persaud, H. L. Gagnon, A. Krueger, A. Modjeski, T. A. Esmat, L. N. Harper, T. A. Vandusseldorp, Garrett Hester

Faculty Articles

High-intensity interval training (HIIT) is an effective alternative to moderate intensity continuous training for improvements in body composition and aerobic capacity; however, there is little work comparing different modalities of HIIT. The purpose of this study was to compare the effects of plyometric- (PLYO) and cycle-oriented (CYC) HIIT on body composition, aerobic capacity, and skeletal muscle size, quality, and function in recreationally trained females. Young (21.7 ± 3.1 yrs), recreationally active females were quasi-randomized (1:1 ratio) to 8 weeks of twice weekly PLYO (n = 15) or CYC (n = 15) HIIT. Body composition (four-compartment model), VO2peak …


Early Education Mentor Match, Erik W. Taylor Aug 2023

Early Education Mentor Match, Erik W. Taylor

Masters Projects

Literature has revealed important information on how establishing mentoring can foster ongoing learning and effective teaching, yet few west Michigan early education environments incorporate any opportunities to encourage these essential relationships. This project explores the recent history of early education learning environments as well as contemporary challenges presented to these programs. Effective teacher supports and ongoing training must acknowledge the necessary out-of-classroom time needed for high-quality instruction and its influence on teacher wellbeing. Mentoring can offer teachers at various points in their careers with rich opportunities to coach and be coached as part of their existing professional development network. The …


Supporting Optimal Recess In Early Childhood Settings, Kristen Spoelman Aug 2023

Supporting Optimal Recess In Early Childhood Settings, Kristen Spoelman

Masters Projects

Research has revealed that US elementary school recess has declined significantly over the past 50 years, including Coopersville Area Public Schools. The major factors that have contributed to this decline include federal policies, adminstrative perspectives, lack of funding and trained staff, and growing concern over safety and behaviors, such as bullying. Scientific investigations have more recently been conducted in response to the recess cuts or eliminations, in order to provide data that demonstrates the crucial need to provide recess to children. These studies, along with growing social organization efforts, have identified that children experience whole child benefit from recess, which …


Apolipoprotein-Ε4 Is Associated With Higher Fecundity In A Natural Fertility Population, Benjamin Trumble, Mia Charifson, Tom Kraft, Angela R. Garcia, Daniel K. Cummings, Paul L. Hooper, Amanda J. Lea, Daniel Eid Rodriguez, Stephanie V. Koebele, Kenneth Buetow, Bret Beheim, Riana Minocher, Maguin Gutierrez, Gregory S. Thomas, Margaret Gatz, Jonathan Stieglitz, Caleb E. Finch, Hillard Kaplan, Michael Gurven Aug 2023

Apolipoprotein-Ε4 Is Associated With Higher Fecundity In A Natural Fertility Population, Benjamin Trumble, Mia Charifson, Tom Kraft, Angela R. Garcia, Daniel K. Cummings, Paul L. Hooper, Amanda J. Lea, Daniel Eid Rodriguez, Stephanie V. Koebele, Kenneth Buetow, Bret Beheim, Riana Minocher, Maguin Gutierrez, Gregory S. Thomas, Margaret Gatz, Jonathan Stieglitz, Caleb E. Finch, Hillard Kaplan, Michael Gurven

ESI Publications

In many populations, the apolipoprotein-ε4 (APOE-ε4) allele increases the risk for several chronic diseases of aging, including dementia and cardiovascular disease; despite these harmful effects at later ages, the APOE-ε4 allele remains prevalent. We assess the impact of APOE-ε4 on fertility and its proximate determinants (age at first reproduction, interbirth interval) among the Tsimane, a natural fertility population of forager-horticulturalists. Among 795 women aged 13 to 90 (20% APOE-ε4 carriers), those with at least one APOE-ε4 allele had 0.3 to 0.5 more children than (ε3/ε3) …


Evaluation Of The Theory Of Planned Behavior (Tpb) To Determine Physical Activity (Pa) In Saudi Female Adolescents In The Eastern Region, Saudi Arabia, Muna Alali Aug 2023

Evaluation Of The Theory Of Planned Behavior (Tpb) To Determine Physical Activity (Pa) In Saudi Female Adolescents In The Eastern Region, Saudi Arabia, Muna Alali

Sigma Foundation for Nursing Research Grant Reports

The purpose of the study is to examine the relationship between psychosocial factors of the Theory of Planned Behavior (TPB) and physical activity (PA) among Saudi female adolescents.


Implementation Of A Wellness Program For Nurse Leaders, Ericson A. Fernando Aug 2023

Implementation Of A Wellness Program For Nurse Leaders, Ericson A. Fernando

Master's Projects and Capstones

Background: The setting for this study is the implementation of a wellness program for nurse leaders at Hospital A, a healthcare organization servicing the South Sacramento area in California. Healthcare is a challenging and high-demand profession, and the COVID-19 pandemic has exacerbated an issue of burnout and unwavering job-related stress for physicians and employees. This remains true for nurse leader professionals who take on the responsibility to ensure safety and quality always remains at ideal measures for any facility.

Problem: During the past several years of the pandemic, the nurse leader role has had to endure several unknowns, placing significant …


Hapi Prevention On A Medical Surgical Telemetry Covid Unit, Maria G. Gonzalez Aug 2023

Hapi Prevention On A Medical Surgical Telemetry Covid Unit, Maria G. Gonzalez

Master's Projects and Capstones

Abstract

Problem: Hospital acquired pressure injures (HAPI) are potentially preventable but frequently occurring events in hospitalized patients. Pressure injuries can occur because of prolonged pressure and in combination with shear and friction forces. HAPI negatively impacts a patient’s quality of life. HAPI also increases the hospital’s financial burden and increases the patient’s length of stay.

Context: The 52-bed medical surgical, telemetry, COVID, unit is one of several unis within a hospital setting. The unit is challenged with the management of HAPIs. The staff are challenged with documenting and escalating the findings, and with finding a second nurse to assist with …


Dimethyl Sulfoxide Inhibits Bile Acid Synthesis In Healthy Mice But Does Not Protect Mice From Bile-Acid-Induced Liver Damage, Xi Chen, Huiqiao Li, Yu'e Liu, Jing Qi, Bingning Dong, Shixia Huang, Shangang Zhao, Yi Zhu Aug 2023

Dimethyl Sulfoxide Inhibits Bile Acid Synthesis In Healthy Mice But Does Not Protect Mice From Bile-Acid-Induced Liver Damage, Xi Chen, Huiqiao Li, Yu'e Liu, Jing Qi, Bingning Dong, Shixia Huang, Shangang Zhao, Yi Zhu

Faculty, Staff and Students Publications

Bile acids serve a vital function in lipid digestion and absorption; however, their accumulation can precipitate liver damage. In our study, we probed the effects of dimethyl sulfoxide (DMSO) on bile acid synthesis and the ensuing liver damage in mice induced by bile acids. Our findings indicate that DMSO efficaciously curbs bile acid synthesis by inhibiting key enzymes involved in the biosynthetic pathway, both in cultured primary hepatocytes and in vivo. Contrarily, we observed that DMSO treatment did not confer protection against bile-acid-induced liver damage in two distinct mouse models: one induced by a 0.1% DDC diet, leading to bile …


Effect Of Cutting Management On The Forage Production And Quality Of Tepary Bean (Phaseolus Acutifolius A. Gray), Travis W. Witt, Brian K. Northup, Timothy G. Porch, Santos Barrera, Carlos A. Urrea Aug 2023

Effect Of Cutting Management On The Forage Production And Quality Of Tepary Bean (Phaseolus Acutifolius A. Gray), Travis W. Witt, Brian K. Northup, Timothy G. Porch, Santos Barrera, Carlos A. Urrea

Department of Agronomy and Horticulture: Faculty Publications

Tepary bean (Phaseolus acutifolius A. Gray) is an underutilized drought tolerant annual legume, originating from the Sonoran Desert, that may be a beneficial forage/hay for beef cattle in the Southern Great Plains of the US (SGP). The SGP has erratic rainfall and periods of intermittent drought exacerbated by high summer temperatures. In 2020 and 2021, a split-plot design was used to evaluate 13 genotypes of tepary bean and a forage soybean (control) at El Reno, OK, USA to compare production of plant biomass and forage nutritive value parameters under seven harvest regimes. Genotypes were used as the main plot …


The Development Of Fetal Immunity From In Utero To Shortly After Birth And Complications That Can Arise From Improper Functioning, Marlee Curnutt Aug 2023

The Development Of Fetal Immunity From In Utero To Shortly After Birth And Complications That Can Arise From Improper Functioning, Marlee Curnutt

Masters Projects

The development of the immune system in humans is highly complex and requires precise timing which is still debated today. Research has shown IL-10 and T-regulatory cells play a significant role in the proper development of the immune system from in utero continuing into months after birth. These components and various cytokines continue to be guiding factors supplemented by the mother via placenta and breastfeeding. The dysregulation of immune development can have detrimental effects on the infant and may lead to autoimmune disorders. In this paper, we aim to further understand the development of the immune system from fetal to …


Ten Questions Concerning Smart And Healthy Built Environments For Older Adults, Sanjay Kumar, Samuel H. Underwood, Julie L. Masters, Natalie A. Manley, Iason Konstantzos, Josephine Lau, Ryan Haller, Lily M. Wang Aug 2023

Ten Questions Concerning Smart And Healthy Built Environments For Older Adults, Sanjay Kumar, Samuel H. Underwood, Julie L. Masters, Natalie A. Manley, Iason Konstantzos, Josephine Lau, Ryan Haller, Lily M. Wang

Durham School of Architectural Engineering and Construction: Faculty Publications

In the past decade, the term ‘global aging’ has gained much attention among researchers, policymakers, civil societies, and governments worldwide. The continuous decline in fertility rates and increased life expectancy have resulted in an ongoing demographic transition where the share of adults aged 65 or older is increasing and outnumbering children younger than five years. In the United States and other developed countries, this rapid demographic transition is expected to continue to strain the existing health infrastructure as it becomes increasingly challenging to ensure healthy living environments for older adults. The ten questions and answers in this paper have been …


Phenylalanine Tolerance Over Time In Phenylketonuria: A Systematic Review And Meta-Analysis, Alex Pinto, Fatma Ilgaz, Sharon Evans, Dam E Van, Júlio César Rocha, Erdem Karabulut, Mary Hickson, Anne Daly, Anita Macdonald Aug 2023

Phenylalanine Tolerance Over Time In Phenylketonuria: A Systematic Review And Meta-Analysis, Alex Pinto, Fatma Ilgaz, Sharon Evans, Dam E Van, Júlio César Rocha, Erdem Karabulut, Mary Hickson, Anne Daly, Anita Macdonald

School of Health Professions

In phenylketonuria (PKU), natural protein tolerance is defined as the maximum natural protein intake maintaining a blood phenylalanine (Phe) concentration within a target therapeutic range. Tolerance is affected by several factors, and it may differ throughout a person’s lifespan. Data on lifelong Phe/natural protein tolerance are limited and mostly reported in studies with low subject numbers. This systematic review aimed to investigate how Phe/natural protein tolerance changes from birth to adulthood in well-controlled patients with PKU on a Phe-restricted diet. Five electronic databases were searched for articles published until July 2020. From a total of 1334 results, 37 articles met …