Digital Commons Network^™

Plant Derived Bioactive Compounds, Their Anti-Cancer Effects As An Alternative Target Treatment Strategy For Breast Cancer: An Updated Overview, Pruthvish Reddy, Sushma Pradeep, S.M. Gopinath, Shiva Prasad Kollur, Chandan Shivamallu

International Journal of Health and Allied Sciences

For decades, cancer has been a major public health concern worldwide owing to its high mortality rate. Many therapeutic strategies have come up in the scientific world, but it's pitiful to know that synthetic chemotherapeutic agents either cause adverse effects or cancer cells develop resistance to these agents. Plant-derived chemotherapeutic agents present a wide range of therapeutics and most are yet to be discovered. In the current review, we have discussed the tumoricidal properties of Mucuna pruriens (seed), Withania coagulans (berry), Anacyclus pyrethrum (rhizome), Arachis hypogea (leaf), Rhizaoma polygoni (root) and Terminalia chebula (fruit). We have also tried to summarize …

Determination Of Vitamin C Stability In Different Packaging Materials At Refrigerated Conditions By Hplc Analysis, Pallavi R, Sushmitha Kc, Anilakumar Kr, Vanitha Reddy P

International Journal of Health and Allied Sciences

The stability of Vitamin C depends on storage temperature, time, and packaging material. Vitamin C is known to prevent the oxidation of low-density lipoprotein primarily by scavenging the free radicals and other reactive oxygen species in the aqueous milieu, ascorbic acid combats cancer by promoting collagen synthesis and thus prevents tumors from invading other tissues. Aim: The present study aims at investigating the Vitamin C content of two citrus fruits under refrigerated conditions after a specific time interval, in different packaging materials. Material: In the present study, two citrus fruits – Amla & Lemon were used to study the stability …

Faculty Senate Committee Agenda October 2, 2023, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:00 Call to Order. Maureen Hearns
• 3:05 University Business. Elizabeth Cantwell, President | Larry Smith, Provost
• 3:20 Faculty Senate Business. Maureen Hearns | John Ferguson | Grant Cardon
• 3:25 Information
• 3:40 Reports
• 3:50 Old Business
• 4:05 New Business
• Adjourn:

Curriculum Subcommittee Agenda October 5, 2023, Utah State University

Educational Policies Committee

• Approval of Minutes - September 7, 2023
• Program Proposals
• Semester Course Approval Reviews
• Other Business
• Adjourn: 3:00 pm

Educational Policies Committee Agenda October 5, 2023, Utah State University

Educational Policies Committee

• Approval of Minutes - September, 2023
• Subcommittee Reports - Curriculum Subcommittee, Academic Standards Subcommittee, General Education Subcommittee
• Other Business
• Adjourn: 4:00 pm

The Grizzly, September 28, 2023, Marie Sykes, Amelia Kunko, Theodora Zeibekis, Renie Christensen, Kate Horan, Andrew J. Perez, Kathy Logan

Ursinus College Grizzly Newspaper, 1978 to Present

Recovery Friendly Workplace • Fall-ing for Ursinus Crossword • Study Tips With Coffeestudi • Correction to "Student Responses to Changes in Good Samaritan Policy" • Two Gentlemen of Lenfest • Two Gentlemen of Verona Rehearsal Photos • Renie and Kate's Meme Corner • A Tasty Trip to the Trappe Tavern • Volleyball Veterans • A Healthy Lifestyle: The Importance of Food and Nutrition

Resistance Training In Humans And Mechanical Overload In Rodents Do Not Elevate Muscle Protein Lactylation, Madison L. Mattingly, Auburn University A. Ruple, Casey L. Sexton, Joshua S. Godwin, Mason C. Mcintosh, Morgan A. Smith, Daniel L. Plotkin, J. Max Michel, Derick A. Anglin, Nicholas J. Kontos, Shengyi Fei, Stuart M. Phillips, C. Brooks Mobley, Ivan Jose Vechetti Jr, Christopher G. Vann, Michael D. Roberts

Department of Nutrition and Health Sciences: Faculty Publications

Although several reports have hypothesized that exercise may increase skeletal muscle protein lactylation, empirical evidence in humans is lacking. Thus, we adopted a multifaceted approach to examine if acute and subchronic resistance training (RT) altered skeletal muscle protein lactylation levels. In mice, we also sought to examine if surgical ablation-induced plantaris hypertrophy coincided with increases in muscle protein lactylation. To examine acute responses, participants’ blood lactate concentrations were assessed before, during, and after eight sets of an exhaustive lower body RT bout (n = 10 trained college-aged men). Vastus lateralis biopsies were also taken before, 3-h post, and 6-h post-exercise …

Critical Contributions Of Protein Cargos To The Functions Of Macrophage‑Derived Extracellular Vesicles, Baolong Liu, Phuong Linh Nguyen, Han Yu, Xingzhi Li, Huiren Wang, Wang Price, Meng Niu, Chittibabu Guda, Xiao Cheng, Xinghui Sun, Regis Moreau, Amanda E. Ramer-Tait, Michael J. Naldrett, Sophie Alvarez, Jiujiu Yu

Department of Nutrition and Health Sciences: Faculty Publications

Background Macrophages are highly plastic innate immune cells that play key roles in host defense, tissue repair, and homeostasis maintenance. In response to divergent stimuli, macrophages rapidly alter their functions and manifest a wide polarization spectrum with two extremes: M1 or classical activation and M2 or alternative activation. Extracellular vesicles (EVs) secreted from differentially activated macrophages have been shown to have diverse functions, which are primarily attributed to their microRNA cargos. The role of protein cargos in these EVs remains largely unexplored. Therefore, in this study, we focused on the protein cargos in macrophage-derived EVs.

Results Naïve murine bone marrow-derived …

The Colby Echo (2023-09-28), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly during the academic year, 1898-present.

Social Interaction, Support Preferences, And The Use Of Wearable Health Trackers, Natalie Pennington, Linda Dam

Hank Greenspun School of Journalism and Media Studies Faculty Research

Introduction: Drawing on uses and gratifications theory, social cognitive theory, and related work, this research assessed how social factors relate to reported weekly use and behavioral intentions toward the use of wearable health trackers (WHT).

Methods: Through two studies we surveyed current users of WHT, including smartwatches, to better understand what factors encouraged engagement. Study One (N = 333) consisted of a college student sample. Study Two (N = 319) was conducted through an online panel from Prolific.

Results: For Study One, results suggested that connection, social comparison, and one's comfort with seeking support predicted weekly use, while …

Gene-By-Environment Interaction In Non-Alcoholic Fatty Liver Disease And Depression: The Role Of Hepatic Transaminases, Eron G. Manusov, Vincent P. Diego, Edward Abrego, Kathryn Herklotz, Marcio A. Almeida, Xi Mao, Sandra L. Laston, John Blangero, Sarah Williams-Blangero

School of Medicine Publications

Non-alcoholic fatty liver disease (NAFLD) encompasses a range of liver conditions, from benign fatty accumulation to severe fibrosis. The global prevalence of NAFLD has risen to 25-30%, with variations across ethnic groups. NAFLD may advance to hepatocellular carcinoma, increases cardiovascular risk, is associated with chronic kidney disease, and is an independent metabolic disease risk factor. Assessment methods for liver health include liver biopsy, magnetic resonance imaging, ultrasound, and vibration-controlled transient elastography (VCTE by FibroScan). Hepatic transaminases are cost-effective and minimally invasive liver health assessment methods options.

This study focuses on the interaction between genetic factors underlying the traits (hepatic transaminases …

Insulin Resistance And Insulin Handling In Chronic Kidney Disease, Vishnu P Parvathareddy, Jiao Wu, Sandhya S Thomas

Faculty, Staff and Students Publications

Insulin regulates energy metabolism involving multiple organ systems. Insulin resistance (IR) occurs when organs exhibit reduced insulin sensitivity, leading to difficulties in maintaining glucose homeostasis. IR ensures decades prior to development of overt diabetes and can cause silent metabolic derangements. IR is typically seen very early in the course of chronic kidney disease (CKD) and is evident even when the estimated glomerular filtration rate (eGFR) is within the normal range and IR persists at various stages of kidney disease. In this article, we will discuss insulin handling by the kidneys, mechanisms responsible for IR in CKD, measurements and management of …

Dpyd Pathogenic Variants Associated With Fluoropyrimidines Toxicity, Diana Cristina Pérez-Ibave, Noé Israel Oliva-García, Irasema Ramos-Martínez, Francisco Javier Villarreal Alvarado, Valeria Jimena Gómez Ordaz, Jonatán Isaí Cortes Alfaro, Carlos Horacio Burciaga-Flores, Juan Francisco González-Guerrero, Oscar Vidal-Gutiérrez, Maria De Lourdes Garza-Rodriguez

Research Symposium

Background: Genetic variants in dihydropyrimidine dehydrogenase gene (DPYD) coding for the key enzyme (DPD) of fluoropyrimidines (FPs) catabolism. DPYD contributes to the development of severe FPs-related toxicity, and pathogenic DPYD variants detection reduces side effects and complications associated with FP-toxicity. The allelic frequency of these variants in the Mexican population is currently unknown.

Methods: The study was carried out at the Centro Universitario Contra el Cáncer (CUCC) of the Universidad Autónoma de Nuevo León (UANL) in Monterrey México. Genomic DNA was isolated from 154 subjects using the QIAamp DNA Blood Midi kit (QIAGEN) following the manufacturer's recommendations. We …

Calling All Students? Enrollment In Community-Engaged Learning Courses At A Marianist University, Molly Malany Sayre, Castel V. Sweet, Kelly Bohrer

Research and Reflection on Learning and Teaching in Higher Education

‘Community’ is a pervasive concept at the University of Dayton, a Catholic, Marianist institution in Dayton, Ohio. As such, it was unknown how students who enrolled in community engaged learning (CEL) courses were different from their peers in demographic characteristics, previous experiential learning, and views of community engagement. Findings can inform CEL recruitment as well as evaluation of CEL outcomes, especially at institutions with a similar values orientation. This mixed-methods study indicates that among four semesters of students in three selected CEL courses, few differences were found with students in non-CEL control groups. One significant difference found was in racial …

Familial Chylomicronemia Syndrome: A Family Case Report In U.S./Mexico Border By Cediamet, Carlos E. Maldonado, Carlo Hector, Mariana Mendez, Claudia Munguia-Cisneros, Leonel Vela, Juan Carlos Lopez Alvarenga

Research Symposium

Primary familiar hyperchylomicronemia syndrome (FHS) is an extremely rare autosomal recessive condition. In 80% of cases is a result of a mutation in lipoprotein lipase, meanwhile, the 20% is a malfunctioning enzyme due to APOC2, APOA5, LMF1, or GP1HBP1. It is estimated FHS affects 3000 to 5000 individuals globally, with no correlation by sex or race. We are presenting a family with FHS in Reynosa, Mexico.

The index patient was a male 36 years old who attended the CEDIAMET clinic after his 6th episode of acute pancreatitis. He has triglycerides 1300 mg/dl and CT scan with Balthazar C score. He …

Response Of Obesity-Resistant Balb/C Mice To A Ketogenic Diet, Ana L. Cantú Ruiz, Diana E. Caballero Hernández, Ana C. Martínez Torres, Ricardo Gomez Flores, Patricia Tamez Guerra, Cristina Rodríguez Padilla

Research Symposium

Introduction. The ketogenic diet (KD) is a high-fat, low-carbohydrate diet in which the body undergoes metabolic adjustments that stimulate ketogenesis, thereby increasing circulating ketone bodies. Loss of body weight is attributed to these adjustments, as well as neuroprotective properties. However, the mechanisms involved are still not fully elucidated. That aim of this work was to evaluate the effect of a ketogenic diet on body composition, feeding behavior and glucose metabolism in mice of the BALB/c strain, a mouse model resistant to obesity.

Materials and methods. BALB/c mice of both sexes, 12 weeks old, were divided into KD and control …

We Are ... Marshall, September 27, 2023, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Spartan Daily, September 27, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 161, Issue 16

Mixed Method Approach Towards The Life Of University Students During The Covid-19 Pandemic, Raihan Khan, Andrew White, Tony Jehi

Department of Health Sciences - Faculty Scholarship

Background

The COVID-19 pandemic negatively impacted the higher education system. This mixed-methods study aimed to assess COVID-19 fear, anxiety, and stress among Shenandoah Valley college students.

Methods

An online survey was fielded and completed by n=680 students. Qualitative semi-structured interviews were conducted with 20 students.

Results

The mean participant age was 22.14±5.48 years, and primarily White (81.9%), women (80.4%), and undergraduate (78.0%) students. Approximately 41% were enrolled in health-related majors (41.4%). Women students had significantly higher anxiety, depression, and fear of contracting COVID-19 than men. Undergraduate students had significantly higher depression than graduate students. Qualitative analysis revealed several major themes: …

The Parthenon, September 27, 2023, Evan Green, Conner Woodruff, Matt Schaffer, Chayce Matheny, Victoria Ware, Shauntelle Thompson, Rafael Alfonso, Scott Price

The Parthenon

No abstract provided.

Circulating Endocannabinoids And N-Acylethanolamines In Individuals With Cannabis Use Disorder-Preliminary Findings, Nadia Boachie, Erin Gaudette, Richard P. Bazinet, Lin Lin, Rachel F. Tyndale, Esmaeil Mansouri, Marilyn A. Huestis, Junchao Tong, Bernard Le Foll, Stephen J. Kish, Tony P. George, Isabelle Boileau

Institute of Emerging Health Professions Faculty Papers

BACKGROUND: Endocannabinoids and related N-acylethanolamines (NAEs) are bioactive lipids with important physiological functions and putative roles in mental health and addictions. Although chronic cannabis use is associated with endocannabinoid system changes, the status of circulating endocannabinoids and related NAEs in people with cannabis use disorder (CUD) is uncertain.

METHODS: Eleven individuals with CUD and 54 healthy non-cannabis using control participants (HC) provided plasma for measurement by high-performance liquid chromatography-mass spectrometry of endocannabinoids (2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (AEA)) and related NAE fatty acids (N-docosahexaenoylethanolamine (DHEA) and N-oleoylethanolamine (OEA)). Participants were genotyped for the functional gene variant of FAAH (rs324420, C385A) which …

The Lumberjack, September 27, 2023

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

September 27, 2023 (Vol. 108, No. 6), Daily Eastern News

Daily Eastern News: 2023-2024

No abstract provided.

Faculty Senate Minutes, Georgia Southern University, Faculty Senate

Faculty Senate Minutes

No abstract provided.

Independent- Sep. 27, 2023, Leslie Lozada

The Independent (1988-present)

No abstract provided.

Design And Synthesis Of Chiral, Conformationally Constrained Fatty Acid Mimetics, Lauren Elizabeth Markham Ph.D.

Dartmouth College Ph.D Dissertations

Fatty acids interact with a wide variety of proteins, as they are either directly or indirectly involved in essentially every physiological process. Mimetics of these fatty acids have the potential to address unique issues associated with these proteins, in ways that the native ligands cannot. The pharmacological panel of targets for fatty acid mimetics is very large and comprises nuclear hormone receptors, cell surface receptors, and enzymes. This thesis describes approaches to the design and synthesis of novel fatty acid mimetics. Specifically, techniques introducing chirality and conformational constraints are employed to produce potent and selective modulators of various receptors. Synthetically, …

Faculty Senate Agenda, Georgia Southern University, Faculty Senate

Faculty Senate Agendas

No abstract provided.

Impact Of Physical Inactivity On Glucose Metabolism And Skeletal Muscle Secretions In Healthy Trained Rats And Potential Counteracting Effects Of Exercise And Protocatechuic Acid, Hira Shakoor

Thesis/ Dissertation Defenses

Modern societies have significantly transformed people's lifestyles, leading to a substantial increase in physical inactivity, which concerns 23% of adults and 81% of adolescents worldwide. Physical inactivity is a major factor contributing to the emergence of chronic diseases, most prominently Type 2 Diabetes (T2D), which exhibits a high prevalence in many countries. T2D is characterized by elevated blood glucose levels due to cells’ responsiveness to insulin. The shift towards inactivity likely occurred more rapidly than the genome's capacity to adapt, resulting in the metabolic dysfunctions underlying the development of T2D. Skeletal muscle is crucial in the onset of these metabolic …

Trauma Talks: Implementation Of Microlearning On A Medical Surgical Unit, Jennifer Michalski, Meghan Smith

2023 Nursing Research Conference

Introduction: Healthcare is dynamic. Nurses, like other healthcare professionals, need to stay up to date on evidence based care and healthcare system changes.

Education must meet:

• Varied learner types

• Generational learner differences

• Be engaging to the learner

• Meet known learner needs/educational gap

• Convenient during a 12 hour shift

• Microlearning, also known as, Just-in-time learning, has gradually integrating into healthcare education delivery with increased implementation seen during the COVID 19 pandemic.

Background: Unit nursing leadership noted gaps in knowledge amongst the nursing staff regarding the specifics of the med-surg patient population. Previous in-services were not …

Buncombe Street Administrative Board Minutes 1975-1980, Buncombe Street United Methodist Church

Methodist Local Church Records

No abstract provided.