Digital Commons Network^™

Longitudinal Magnetic Resonance Imaging-Based Superficial Femoral Artery Velocity Measurements In Diabetic And Nondiabetic Patients With Peripheral Artery Disease, Ankita Sinharoy, Neeti Reddy, John Kent Lin, Vijay Nambi, Eric Y Yang, Panagiotis Kougias, Addison A Taylor, Alan B Lumsden, Christie M Ballantyne, Gerd Brunner

Faculty, Staff and Students Publications

Background: Longitudinal associations of noninvasive 2-dimensional phase-contrast magnetic resonance imaging (2D-PC-MRI) velocity markers of the superficial femoral artery (SFA) were analyzed along with the characteristics of peripheral artery disease (PAD). We hypothesized that the 2-year differences in MRI-based measures of SFA velocity were associated with longitudinal changes in markers of PAD.

Methods: A total of 33 (11 diabetic, 22 nondiabetic) patients with PAD with baseline and 2-year follow-up MRI scans were included in this secondary analysis of the Effect of Lipid Modification on Peripheral Artery Disease after Endovascular Intervention Trial (ELIMIT). Electrocardiographically gated 2D-PC-MRI was performed at a proximal and …

Muc13 Drives Cancer Aggressiveness And Metastasis Through The Yap1-Dependent Pathway, Kyle Doxtater, Manish Tripathi, Radhiki Sekhri, Bilal B. Hafeez, Sheema Khan, Nadeem Zafar, Stephen Behrman, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications

Anchorage-independent survival after intravasation of cancer cells from the primary tumor site represents a critical step in metastasis. Here, we reveal new insights into how MUC13-mediated anoikis resistance, coupled with survival of colorectal tumor cells, leads to distant metastasis. We found that MUC13 targets a potent transcriptional coactivator, YAP1, and drives its nuclear translocation via forming a novel survival complex, which in turn augments the levels of pro-survival and metastasis-associated genes. High expression of MUC13 is correlated well with extensive macrometastasis of colon cancer cells with elevated nuclear YAP1 in physiologically relevant whole animal model systems. Interestingly, a positive correlation …

Type 2 Diabetes Modifies The Association Of Cad Genomic Risk Variants With Subclinical Atherosclerosis, Natalie. R. Hasbani, Kenneth E. Westerman, Soo Heon Kwak, Han Chen, Xihao Li, Daniel Di Corpio, Michael C. Mahaney, Ravi Duggirala, Joanne E. Curran, John Blangero

School of Medicine Publications

Background: Individuals with type 2 diabetes (T2D) have an increased risk of coronary artery disease (CAD), but questions remain about the underlying pathology. Identifying which CAD loci are modified by T2D in the development of subclinical atherosclerosis (coronary artery calcification [CAC], carotid intima-media thickness, or carotid plaque) may improve our understanding of the mechanisms leading to the increased CAD in T2D.

Methods: We compared the common and rare variant associations of known CAD loci from the literature on CAC, carotid intima-media thickness, and carotid plaque in up to 29 670 participants, including up to 24 157 normoglycemic controls and 5513 …

Non-Invasive Glucose Detection Using A Triple Pole Csrr Sensor, Chibuike Nnabuife Okika

Theses

A compact, low-cost, portable, non-invasive blood glucose sensor has been designed and presented in this paper. The proposed sensor is a triple-pole square Complementary Split Ring Resonator (CSRR) sensor that is etched on an FR4 substrate. At the bottom of the sensor is coupled an etched Microstrip Transmission Line (MTL) with an impedance matching of 50 Ω, which excites the sensor elements. Utilizing the CSRR-based sensor overcomes the disadvantages of pain and discomfort that the traditional method of pricking the skin to measure blood glucose levels could pose. The sensors work in such a way that as the glucose concentration …

Review Classification Using Natural Language Processing And Deep Learning, Brian Nazareth

Electronic Theses, Projects, and Dissertations

Sentiment Analysis is an ongoing research in the field of Natural Language Processing (NLP). In this project, I will evaluate my testing against an Amazon Reviews Dataset, which contains more than 100 thousand reviews from customers. This project classifies the reviews using three methods – using a sentiment score by comparing the words of the reviews based on every positive and negative word that appears in the text with the Opinion Lexicon dataset, by considering the text’s variating sentiment polarity scores with a Python library called TextBlob, and with the help of neural network training. I have created a neural …

Statistical Analysis Of Health Habits For Incoming College Students, Wendy Isamara Lizarraga Noriega

Electronic Theses, Projects, and Dissertations

Health habits among college students are commonly overseen, especially for students transitioning from high school right into college. These students are becoming independent young adults, and learning how to adapt to a different scenery when it comes to their learning environment. As these young adults transition into college, this is the perfect time for the students to become more vulnerable and comfortable with their independence, and their weight begins to fluctuate. Many variables come into consideration when increasing weight as an incoming first-year student. Students are more likely to live alone, get a job, and rely on fast food and …

Idiographic Coping Outcomes In Youth With Autism Spectrum Disorder And Co-Occurring Anxiety: Results From The Taasd Study, Lesley A Norris, Jonathan C Rabner, Eric A Storch, Jeffrey J Wood, Connor Kerns, Adam B Lewin, Brent J Small, Philip C Kendall

Center for Medical Ethics and Health Policy Staff Publications

Versions of cognitive behavioral therapy (Coping Cat, CC; Behavioral Interventions for Anxiety in Children with Autism, BIACA) have shown efficacy in treating anxiety among youth with autism spectrum disorder. Measures of efficacy have been primarily nomothetic symptom severity assessments. The current study examined idiographic coping outcomes in the Treatment of Anxiety in Autism Spectrum Disorder study (N = 167). Longitudinal changes in coping with situations individualized to youth fears (Coping Questionnaire) were examined across CC, BIACA and treatment as usual (TAU) in a series of multilevel models. CC and BIACA produced significantly greater improvements than TAU in caregiver-reported coping. Youth …

Ezh2 Cooperates With Brd4-Nut To Drive Nut Carcinoma Growth By Silencing Key Tumor Suppressor Genes, Yeying Huang, R Taylor Durall, Nhi M Luong, Hans J Hertzler, Julianna Huang, Prafulla C Gokhale, Brittaney A Leeper, Nicole S Persky, David E Root, Praju V Anekal, Paula D L M Montero Llopis, Clement N David, Jeffery L Kutok, Alejandra Raimondi, Karan Saluja, Jia Luo, Cynthia A Zahnow, Biniam Adane, Kimberly Stegmaier, Catherine E Hawkins, Christopher Ponne, Quan Le, Geoffrey I Shapiro, Madeleine E Lemieux, Kyle P Eagen, Christopher A French

Faculty, Staff and Student Publications

NUT carcinoma (NC) is an aggressive carcinoma driven by the BRD4-NUT fusion oncoprotein, which activates chromatin to promote expression of pro-growth genes. BET bromodomain inhibitors (BETi) are a promising treatment for NC that can impede BRD4-NUT’s ability to activate genes, but the efficacy of BETi as monotherapy are limited. Here, we demonstrated that EZH2, which silences genes through establishment of repressive chromatin, is a dependency in NC. Inhibition of EZH2 with the clinical compound tazemetostat (taz) potently blocked growth of NC cells. Epigenetic and transcriptomic analysis revealed that taz reversed the EZH2-specific H3K27me3 silencing mark and restored expression of multiple …

Whole-Genome Sequencing Uncovers Two Loci For Coronary Artery Calcification And Identifies Arse As A Regulator Of Vascular Calcification, Paul S De Vries, Matthew P Conomos, Kuldeep Singh, Christopher J Nicholson, Deepti Jain, Natalie R Hasbani, Wanlin Jiang, Sujin Lee, Christian L Lino Cardenas, Sharon M Lutz, Doris Wong, Xiuqing Guo, Jie Yao, Erica P Young, Catherine Tcheandjieu, Austin T Hilliard, Joshua C Bis, Lawrence F Bielak, Michael R Brown, Shaila Musharoff, Shoa L Clarke, James G Terry, Nicholette D Palmer, Lisa R Yanek, Huichun Xu, Nancy Heard-Costa, Jennifer Wessel, Margaret Sunitha Selvaraj, Rebecca H Li, Xiao Sun, Adam W Turner, Adrienne M Stilp, Alyna Khan, Anne B Newman, Asif Rasheed, Barry I Freedman, Brian G Kral, Caitlin P Mchugh, Chani Hodonsky, Danish Saleheen, David M Herrington, David R Jacobs, Deborah A Nickerson, Eric Boerwinkle, Fei Fei Wang, Gerardo Heiss, Goo Jun, Greg L Kinney, Haakon H Sigurslid, Harshavardhan Doddapaneni, Ira M Hall, Isabela M Bensenor, Jai Broome, James D Crapo, James G Wilson, Jennifer A Smith, John Blangero, Jose D Vargas, Jose Verdezoto Mosquera, Joshua D Smith, Karine A Viaud-Martinez, Kathleen A Ryan, Kendra A Young, Kent D Taylor, Leslie A Lange, Leslie S Emery, Marcio S Bittencourt, Matthew J Budoff, May E Montasser, Miao Yu, Michael C Mahaney, Mohammed S Mahamdeh, Myriam Fornage, Nora Franceschini, Paulo A Lotufo, Pradeep Natarajan, Quenna Wong, Rasika A Mathias, Richard A Gibbs, Ron Do, Roxana Mehran, Russell P Tracy, Ryan W Kim, Sarah C Nelson, Scott M Damrauer, Sharon L R Kardia, Stephen S Rich, Valentin Fuster, Valerio Napolioni, Wei Zhao, Wenjie Tian, Xianyong Yin, Yuan-I Min, Alisa K Manning, Gina Peloso, Tanika N Kelly, Christopher J O'Donnell, Alanna C Morrison, Joanne E Curran, Warren M Zapol, Donald W Bowden, Lewis C Becker, Adolfo Correa, Braxton D Mitchell, Bruce M Psaty, John Jeffrey Carr, Alexandre C Pereira, Themistocles L Assimes, Nathan O Stitziel, John E Hokanson, Cecelia A Laurie, Jerome I Rotter, Ramachandran S Vasan, Wendy S Post, Patricia A Peyser, Clint L Miller, Rajeev Malhotra

Faculty, Staff and Student Publications

Coronary artery calcification (CAC) is a measure of atherosclerosis and a well-established predictor of coronary artery disease (CAD) events. Here we describe a genome-wide association study (GWAS) of CAC in 22,400 participants from multiple ancestral groups. We confirmed associations with four known loci and identified two additional loci associated with CAC (ARSE and MMP16), with evidence of significant associations in replication analyses for both novel loci. Functional assays of ARSE and MMP16 in human vascular smooth muscle cells (VSMCs) demonstrate that ARSE is a promoter of VSMC calcification and VSMC phenotype switching from a contractile to a calcifying …

Just Extracurriculars?, Emily Gold Waldman

Elisabeth Haub School of Law Faculty Publications

Extracurricular activities have been the battleground for a striking number of Supreme Court cases set at public schools, from cases involving speech to religion to drug testing. Indeed, the two most recent Supreme Court cases involving constitutional rights at public schools--Kennedy v. Bremerton School District (2022) and Mahanoy Area School District v. B.L. (2021)--both arose in the extracurricular context of school sports. Even so, the Supreme Court has never fully clarified the status of extracurricular activities themselves. Once a school offers an extracurricular activity, is participation merely a privilege? Does the fact that extracurricular activities are voluntary for students affect …

Cementing Success: The Impact That Mentoring Has On Women Of Color Business Owners In The Construction Industry, Nneka Bell

Education Doctoral

The number of women of color entrepreneurs in the construction industry lags significantly behind that of their White women and male counterparts. The construction industry is one of the most gender-segregated industries in the world. Women of color entrepreneurs have encountered barriers to forming mentoring relationships, impacting their success in entrepreneurial endeavors. This qualitative phenomenological study examines how women of color entrepreneurs perceive the professional mentoring experience. This study examines women of color entrepreneurs’ experience of professional mentoring and whether it contributed to their success. This study identified successful professional mentoring elements for women of color entrepreneurs and assessed professional …

Black And Latiné College Student Expectations And Perceptions Of A College Leadership’S Responses To Nationally Known, Racially Biased Incidents, Grace Maxon-Clarke

Education Doctoral

The purpose of this qualitative descriptive phenomenological study was to understand Black and Latiné students’ expectations and perceptions of their college leaderships’ responses to nationally known, biased incidents. Through a qualitative, descriptive phenomenological design, 11 participants, within one institution, across three focus groups, shared their expectations and perspectives. The data analysis was done using open-ended coding to determine the major themes and codes across all focus groups.

Themes for student expectations were (a) no expectation: first-year student, COVID restrictions, primarily White institutions; (b) expectations met: met the needs of the White majority, public institution; and (c) expected different: expected more, …

Predicting Njcaa Student-Athlete Success: An Analysis Of Graduation Over A 5-Year Period Using Precollege And College Variables At A 2-Year Institution, Alina Nazari

Education Doctoral

College student-athletes have to navigate unique challenges in order to graduate on time primarily due to their dual roles on campus (Beron & Piquero, 2016; Cooper et al., 2017). While previous research has primarily explored predictors of academic success (e.g., graduation within 150% of the standard completion time) among student-athletes at NCAA Division I institutions,

this study addressed the significant gap in knowledge specific to NJCAA Division I student- athletes. This quantitative study extended the work of Autry (2010) by investigating the

precollege and college predictors of academic success among 2-year student-athletes at a NJCAA Division I institution in the …

The Role Of Muslim Communities In Easing The Challenges For Young U.S. Muslim Immigrant Children’S School Outcomes, Ghada Kassir

Electronic Theses, Projects, and Dissertations

American Muslims have increasingly experienced Islamophobia-related discrimination and stereotypes, including unjust accusations of violence, hatred, and terrorism, especially since 9/11. This study investigates the experience of Muslim immigrants in the U.S. and its impact on their children’s school outcomes. Using the theoretical frameworks of segmented assimilation, acculturation, social identity theory, and critical race theory, post-9/11 Muslim immigrants and their elementary school children are the focus of this study. Specifically, this study examines the associations among the following constructs: Muslim identity, culture and traditions, community connectedness, and children's school outcomes. This study hypothesized that there is a negative correlation between Muslim …

A Perfect Storm For Legal Education: Privatization, Polarization, And Pedagogy, Rachel F. Moran

Faculty Scholarship

Today, the legal profession faces new challenges to its integrity and legitimacy due to technological change, rising political polarization, and a stratified bar. In this Article, I first explore how technological innovations are undermining lawyers’ claims to a unique monopoly based on expert professionalism. These technologies are designed to transform routinized law practice in ways that improve efficiency. With little focus on attorneys’ obligations to serve the greater good, technology entrepreneurs emphasize practical advantages over traditional forms of representation. These proponents promise reduced costs and superior results through a single-minded commitment to market dynamics. Those promises in turn depend on …

Final Report Of The Mexican Reintegration Project Study, Guillermo J. Garcia Sanchez, Sonia Hernandez, Luz E. Herrera, Angela D. Morrison, Huyen Pham, Nancy Plankey-Videla

Faculty Scholarship

The phenomenon of Mexicans returning to Mexico after an extended stay in the United States is an increasingly important one. Though estimates for the period from 2014 through 2019 show that more Mexicans have migrated to the United States than left, net migration is still well below that of peak net migration from 1995 to 2000. In the period of 2014-2019, the net migration of Mexican nationals to the United States was only 160,000 versus 2.3 million during the period from 1995 to 2000. From 2005–2014, the U.S. experienced an outmigration of Mexican nationals, as more Mexicans left the U.S. …

Reporte Final Del Estudio Del "Proyecto De Reintegración Mexicana", Guillermo J. Garcia Sanchez, Sonia Hernandez, Luz E. Herrera, Angela D. Morrison, Huyen Pham, Nancy Plankey-Videla

Faculty Scholarship

El fenómeno de los mexicanos que estan regresando a México después de una estadía prolongada en Estados Unidos es cada vez más importante. Aunque las estimaciones para el período de 2014 a 2019 muestran que más mexicanos han migrado a Estados Unidos de los que se fueron, la migración neta todavía está muy por debajo del pico de migración neta de 1995 a 2000. En el período de 2014-2019, la migración neta de mexicanos a Estados Unidos era de tan solo 160,000 versus 2.3 millones durante el periodo de 1995 a 2000. Entre 2005 y 2014, Estados Unidos experimentó una …

Advancing Health Information During Interhospital Transfer: An Interrupted Time Series, Stephanie K Mueller, Pamela Garabedian, Eric Goralnick, David W Bates, Lipika Samal

Faculty, Staff and Students Publications

Introduction: Although the transfer of patients between acute care hospitals (interhospital transfer, IHT) is common, health information exchange (HIE) during IHT remains inadequate, with fragmented communication and unreliable access to clinical information. This study aims to design, implement, and rigorously evaluate the implementation of a HIE platform to improve data access during IHT.

Methods and analysis: Study subjects include patients aged >18 transferred to the medical, cardiology, oncology, or intensive care unit (ICU) services at an 800-bed quaternary care hospital; and healthcare workers involved in their care. The first aim of this study is to optimize clinician workflow, data visualization, …

Too Many, Too Late: The Nfl’S Inverse Accessibility Issue And The New Rpo, Scott M. Finney

North Carolina Journal of Law & Technology

No abstract provided.

No Need To Reinvent The Wheel: Why The U.S. Should Implement Co-Regulatory Mechanisms To Regulate Deepfake Content On Internet Platforms, Abe Loven

North Carolina Journal of Law & Technology

No abstract provided.

Factors Influencing Military Instructor Technology Self-Efficacy, Gina D. Frank

Boise State University Theses and Dissertations

Technological self-efficacy is considered the dominant determinant of the intention to use technology to achieve learning outcomes. Researchers in the K-12 environment have utilized self-efficacy theory, and the factors influencing it, to aid teachers in integrating technology into their classrooms, yet similar research has not been conducted on military instructors. This sequential, explanatory mixed methods study sought to identify specific factors affecting military instructors’ levels of technology self-efficacy. The study was conducted on military instructors at a base in the southern United States and used the Computer Technology Integration Survey and semi-structured interview questions to find answers to three research …

Making Meaning Of Multimodalities In Teacher Professional Learning, Jonathan Doane Shaw

Dissertations

The purpose of this study was to better understand multimodal usage in teacher professional learning. Thus, this qualitative phenomenology study was created and executed to better understand how leaders of teacher professional learning understand and implement modes in courses designed for teacher scholarship. Focusing on leader influences, curricular designs, learning ecologies, systemic functional linguistics, and teachers as students, modalities support learning by providing individuality through universal design. Thematic analysis illuminated four main themes and 10 subthemes were identified. The findings are of interest to a wide range of educators-teachers, professional learning leaders, principals, students, and policy makers. My paper discusses …

Sediment Delivery To Sustain The Ganges-Brahmaputra Delta Under Climate Change And Anthropogenic Impacts, Jessica L. Raff, Steven L. Goodbred, Jennifer L. Pickering, Ryan S. Sincavage, John C. Ayers, Md Saddam Hossain, Carol A. Wilson, Chris Paola, Michael S. Steckler, Dhiman R. Mondal, Jean Louis Grimaud, Celine Jo Grall, Kimberly G. Rogers, Kazi Matin Ahmed, Syed Humayun Akhter, Brandee N. Carlson, Elizabeth L. Chamberlain, Meagan Dejter, Jonathan M. Gilligan, Richard P. Hale, Mahfuzur R. Khan, Md Golam Muktadir, Md Munsur Rahman, Lauren A. Williams

Faculty Publications

The principal nature-based solution for offsetting relative sea-level rise in the Ganges-Brahmaputra delta is the unabated delivery, dispersal, and deposition of the rivers’ ~1 billion-tonne annual sediment load. Recent hydrological transport modeling suggests that strengthening monsoon precipitation in the 21st century could increase this sediment delivery 34-60%; yet other studies demonstrate that sediment could decline 15-80% if planned dams and river diversions are fully implemented. We validate these modeled ranges by developing a comprehensive field-based sediment budget that quantifies the supply of Ganges-Brahmaputra river sediment under varying Holocene climate conditions. Our data reveal natural responses in sediment supply comparable to …

Robot Job Destroyers, Henry H. Perritt Jr.

Louisiana Law Review

No abstract provided.

Meet The Students And Organizations Collaborating To Tackle Climate Change, Sustainability Institute

Sustainability Institute Blog

No abstract provided.

News From Uab Libraries, 12 2023, Uab Libraries

UAB Libraries News

No abstract provided.

Childcare Organizations: A Qualitative Study On Childcare Leaders’ Perceptions Of The Elements That Promote The Work They Do In The Childcare Industry, Paula S. Polito Mrs.

LSU New Orleans Theses and Dissertations

Research has often highlighted the positive effects of high-quality early care and education on children's development and the economy. However, the challenge of ensuring access to quality care for all children and understanding the perspectives of leaders doing crucial work on the ground remains. Given the strong associations between high-quality early childhood education, brain development, and positive economic outcomes for those who access high-quality care, my paper introduces a theory of change. This theory outlines a pathway from understanding the determinants of quality in childcare centers, as seen through the eyes of industry leaders, to the implementation of policy changes. …

On The Synthesis Of Heavy Rare Earth Solid Solutions And Their Hydrides, Joshua R. Van Cleave

UNLV Theses, Dissertations, Professional Papers, and Capstones

The theoretical predictions and results from the (La,Y)Hx ternary hydride solution provided evidence toward phase stability at comparatively lower pressures, as consequence the (Yb,Lu)H_x and (Tm,Lu)H_x ternary hydrides are studied here with pressures up to 25 GPa in the diamond anvil cell. The onset of an unknown feature in the XRD pattern coincides with crystallographic plane distortions in the tetragonal lattice of ytterbium hydride at their laser-heated interface, possibly driven by a solid solution of Lu-Yb. Findings in collected Raman spectra and X-ray diffraction patterns in an Ar environment suggest potential stability of the FCC and high-temperature HCP …

An Analogue Study Of Expected Working Alliance And Hope With Victims Of Military Sexual Trauma Among Civilian And Military-Oriented Therapists, Alishia D. Salyer

Dissertations

Victims of military sexual trauma (MST) face unique challenges as they pursue mental health treatment and supportive care. Understanding what factors impact potential treatment outcomes is critical in aiding in their recovery (Castro et al., 2015; Kroviak, 2020). Although a substantial amount of research has been conducted to evaluate prevalence and client factors associated with treating victims of MST (Teit et al., 2015; Turchik & Wilson, 2010), little is known about therapists’ factors including therapists’ expectations working with such clients. The purpose of this study was to examine the relationships between therapist type (military-affiliated versus civilian), therapist gender, client gender, …

Embryotoxic Effects Of Three Natural Occurring Veratrum Alkaloids And One Synthetic Analog Using In Vitro Produced Bovine Embryos, Kevin D. Welch, Shiquan Wang, Stephen T. Lee, Dale R. Gardner, Kip E. Panter

Poisonous Plant Research (PPR)

Three natural occurring plant toxins from Veratrum californicum and one related synthetic analog were screened for embryotoxicity using in vitro bovine embryo production techniques. Bovine oocytes were aspirated from ovaries collected from a local abattoir and embryos were generated through in vitro maturation (IVM) and in vitro culture (IVC) procedures. The three natural steroidal alkaloids, cyclopamine, jervine and veratramine and the synthetic steroidal derivative of cyclopamine, cyclopamine-4-en-3-one, were added to IVM and IVC media at 12 μM. Oocytes were exposed to the toxins during maturation (IVM) and pre-implantation embryo during culture (IVC). Cleavage rates and embryo growth (morula and blastocyst …