Digital Commons Network^™

Review Of "Is Social Justice Just?", Jonathan Lawler

The Christian Librarian

No abstract provided.

Expression Of Pfkfb Isoenzymes During In Vitro Differentiation Of Mouse Embryonic Stem Cells Into Insulin-Producing Cells, Sai̇me Güzel, Abdullah Yalçin, Yunus Gürpinar, Sabi̇re Güler

Turkish Journal of Medical Sciences

Background/aim: Type 1 diabetes mellitus (T1DM) is caused by the autoimmune-mediated destruction of insulin-producing cells (IPCs) and still has no effective cure. Better understanding of the molecular mechanisms involved in the differentiation of embryonic stem cells (ESCs) into IPCs may help us improve the therapeutic strategies for treating T1DM. 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatases (Pfkfb1-4) are key regulators of glucose metabolism. Although Pfkfb3 has been shown to be required for the growth of early differentiated mouse ESCs (mESCs), more studies are needed to further assess the roles of Pfkfb isoenzymes in embryonic development and differentiation, particularly into specific cell types. In this study, …

Formate Supplementation Enhances Antitumor Cd8+ T-Cell Fitness And Efficacy Of Pd-1 Blockade, Jared H Rowe, Ilaria Elia, Osmaan Shahid, Emily F Gaudiano, Natalia E Sifnugel, Sheila Johnson, Amy G Reynolds, Megan E Fung, Shakchhi Joshi, Martin W Lafleur, Joon Seok Park, Kristen E Pauken, Joshua D Rabinowitz, Gordon J Freeman, Marcia C Haigis, Arlene H Sharpe

Faculty, Staff and Student Publications

UNLABELLED: The tumor microenvironment (TME) restricts antitumor CD8+ T-cell function and immunotherapy responses. Cancer cells compromise the metabolic fitness of CD8+ T cells within the TME, but the mechanisms are largely unknown. Here we demonstrate that one-carbon (1C) metabolism is enhanced in T cells in an antigen-specific manner. Therapeutic supplementation of 1C metabolism using formate enhances CD8+ T-cell fitness and antitumor efficacy of PD-1 blockade in B16-OVA tumors. Formate supplementation drives transcriptional alterations in CD8+ T-cell metabolism and increases gene signatures for cellular proliferation and activation. Combined formate and anti-PD-1 therapy increases tumor-infiltrating CD8+ T cells, which are essential for …

Mapping The Unseen: Harnessing Indigenous Knowledge Through Participatory Mapping To Address Displacement And Housing Challenges In Post Invasion Iraq, Sana Murrani

School of Art, Design and Architecture

Post-invasion Iraq has been grappling with high rates of internal displacement and severe housing shortages for the past 20years, largely fuelled by violence, genocide and political instability. The intricacy of these interrelated challenges necessitates contextually informed, innovative and participatory approaches to effect change. This paper proposes the use of participatory mapping as a creative tool to tap into the indigenous knowledge and wayfinding skills of Iraqis, fostering a deeper understanding of the lived realities that can contribute to the design of effective policies for managing displacement and housing issues. The rising trend of internal displacement and the subsequent housing shortages, …

Prevalence Of Missed Opportunities For Immunization And Its Associated Factors Among Children Below Two Years Old Attending Primary Healthcare Centers In Baghdad/Al-Karkh, Baraka Safaa’ Mustafa, Jalil Ibrahim Saleh

Muthanna Medical Journal

Immunization is an effective means for preventing illness and reducing the burden of various infectious diseases. Incomplete or partial immunization poses a serious threat to the health of children in many developing countries, including Iraq. The objectives are to investigate the prevalence of missed opportunities for immunization (MOI) and its associated factors among children aged below two years old attending primary health care centers (PHCCs) in Baghdad/Al-Karkh. A cross-sectional study involving 500 children’s companions attending PHCCs in Baghdad/Al-Karkh from the 1st of September 2022 to the 1st of July 2023. The respondents were enrolled using a systematic random sample technique …

Commercial Adsorbents For Co2 Removal For Biogas Upgradation: An Experimental Study, Aakriti Bagla

McKelvey School of Engineering Graduate Student Theses & Dissertations

No abstract provided.

In The Hot Seat: Acquiring Kernel Density Heat Map Design Guidance Through Delphi And Survey Methods, Lauren Eileen Mckinney-Wise

Dissertations and Theses

Kernel density heat maps have emerged as a new, popular thematic map type. Yet, unlike other thematic map types, little if any published guidance exists for effective heat map design. This is significant because maps are highly persuasive objects that are often utilized to communicate important information, but maps can also be misleading and misunderstood. Therefore, proper guidance for heat map creation is critical for cartographers to create maps that convey geographic information successfully.

To address this literature gap, I used a modified Delphi method and an online survey to investigate several questions, including understanding what cartographic experts think are …

Development And Validation Of A Multiplex Real-Time Pcr Assay For Detection And Quantification Of Streptococcus Pneumoniae In Pediatric Respiratory Samples, Molly Butler, Garrett Breazeale, Eric Mwangi, Elaine Dowell, Samuel R Dominguez, Linda Lamberth, Kristina G Hultén, Sarah A Jung

Faculty, Staff and Students Publications

Streptococcus pneumoniae (Spn) is a bacterial pathogen that causes a range of disease manifestations in children, from acute otitis media to pneumonia, septicemia, and meningitis. Primary Spn laboratory diagnostic identification methods include culture, antigen testing, single-plex real-time PCR, and syndromic PCR panels. However, each method lacks sensitivity, specificity, and/or cost efficiency. We developed and validated a quantitative, multiplex PCR assay using three Spn genomic targets (lytA, piaB, and SP2020) for improved sensitivity and specificity to detect Spn in pleural fluid (PF), bronchoalveolar lavage (BAL), tracheal aspirate (TA), and upper respiratory (UR, research only) samples. Validation testing …

Radicalisation And Extremism On Social Media: What Steps Can Be Taken?, Emeka Williams Etumnu, Oluchi I. Williams-Etumnu

Library Philosophy and Practice (e-journal)

Unarguably, the social media has brought the world together in an online space and as a result of this, extremist groups utilise the social media to radicalise people especially the youths who are vulnerable and fancy their ideology towards their cause. The paper was underpinned on public sphere theory and the desk research method was employed in the course of the study. It was revealed that social media plays a tremendous role towards radicalisation and extremism. The need for digital literacy, where rules can be made to assist individuals of all ages in developing critical thinking skills and building resilience …

Recruitment And Retention Challenges In Adult Care Facilities, Shirley Ann Jones

Walden Dissertations and Doctoral Studies

No abstract provided.

A Patterned Human Primitive Heart Organoid Model Generated By Pluripotent Stem Cell Self-Organization, Brett Volmert, Chao Zhou, Et Al.

2020-Current year OA Pubs

Pluripotent stem cell-derived organoids can recapitulate significant features of organ development in vitro. We hypothesized that creating human heart organoids by mimicking aspects of in utero gestation (e.g., addition of metabolic and hormonal factors) would lead to higher physiological and anatomical relevance. We find that heart organoids produced using this self-organization-driven developmental induction strategy are remarkably similar transcriptionally and morphologically to age-matched human embryonic hearts. We also show that they recapitulate several aspects of cardiac development, including large atrial and ventricular chambers, proepicardial organ formation, and retinoic acid-mediated anterior-posterior patterning, mimicking the developmental processes found in the post-heart tube stage …

Kids For A Happy Marriage? A Preliminary Study On Marriage Satisfaction And Presence Or Absence Of Children Among Married Individuals In Indonesia, Alftisya Victory Hutabarat, Karel Karsten Himawan

Makara Human Behavior Studies in Asia

Having children after marriage tends to be seen as a normative practice in Indonesia. As a result, individuals who do not have children could be at risk of experiencing a set of social stigmas. The study aims to explore whether having children is associated with one’s marital satisfaction. In particular, the present study aims to explore the differences in marital satisfaction among married individuals who have biological children, who are childfree (voluntarily childless), and who are childless (involuntarily childless). A cross-sectional survey was conducted to 210 married individuals (M age = 34.3; SD = 7.9). The result shows that …

Guidelines For Sustainable Use Of Mobile Instant Messaging Apps In Higher Education: A South African Case Study, Bronwyn C. Swartz, Sweta Patnaik

Higher Learning Research Communications

Objective: The purpose of the study was to propose guidelines to facilitate the sustainable and successful use of mobile instant messaging apps for learning and teaching based on a review of the literature and perceptions of educators. Fraser’s model of redistribution, recognition, and representation served as the theoretical framework. This study provides a mechanism for the development of a socially just and inclusive online classroom environment.

Method: We conducted two focus groups (n = 4 and n = 3) in November 2021 at a university of technology in South Africa to explore the perceptions of educators on using mobile …

Vol. 21 Entire Issue

The Journal of Economics and Politics

No abstract provided.

Vol. 20 Entire Issue

The Journal of Economics and Politics

No abstract provided.

Vol. 19 Entire Issue

The Journal of Economics and Politics

No abstract provided.

One Birder's Falcon, Matt Pelikan

Bird Observer

No abstract provided.

Massachusetts Miracles: The Gull And The Falcon, Wayne R. Petersen, Paul J. Baicich

Bird Observer

No abstract provided.

About Books: Strangers In The Night, Mark Lynch

Bird Observer

No abstract provided.

About The Cover: Piping Plover, William E. Davis Jr.

Bird Observer

No abstract provided.

Bird Sightings: September-October 1999, Jim Berry, Seth Kellogg, Simon A. Perkins, Marjorie W. Rines, Robert H. Stymeist

Bird Observer

No abstract provided.

Index To Volumes 25 And 26, 1997 And 1998, Matthew L. Pelikan

Bird Observer

No abstract provided.

Book Review: Red-Tails In Love By Marie Winn, Alden Clayton

Bird Observer

No abstract provided.

The Aba Code Of Ethics: What It Is, What It Does, Blake Maybank

Bird Observer

No abstract provided.

After The Owl: Reflections On Big Birds, Matthew L. Pelikan

Bird Observer

No abstract provided.

Book Review: A Guide To The Birds Of Mexico And Northern Central America By Steve N.G. Howell, Peter C. Alden

Bird Observer

No abstract provided.

Contents, Bird Observer

Bird Observer

No abstract provided.

Final Session. The Impact Of Storytelling: The Pass It On Project, Gloria Burgess, Karen Davidson-Smith, Cade Smith, Elizabeth Mitchell Prewitt

School Library Symposium

Learn about this exciting act of kindness campaign through a guided conversation with author Dr. Gloria Burgess. Her book, Pass It On, has been used to support Mississippi Studies in 4th and 8th grades. Discover how this partnership between the UM Center for Community Engagement, UM School of Education, the University Museum, and the Lafayette County School District, led to the creation of an activity trunk participants can use at their schools. Participants will also hear from speakers Dr. Karen V. Davidson Smith, UM School of Education Director of Diversity, Equity and Inclusion/Clinical Associate Professor, and Dr. Elizabeth Mitchell Prewitt, …

Transcribing Letters To James Meredith (Concurrent Session, Block D), Adam Clemons, Abbie Norris-Davidson

School Library Symposium

On October 1, 1962, James Meredith made history as the first African-American student to be admitted to the then racially segregated University of Mississippi. In the weeks before and after his admission, Meredith received thousands of letters from around the world expressing support or condemnation of his actions. Today, many of these letters are housed at the University of Mississippi Archives and Special Collections and have been digitized and made publicly available on eGrove, the University’s institutional repository. Adam Clemons, UM Digital Humanities and Data Visualization Librarian and Assistant Professor, and Abbie Norris-Davidson, UM Digital Initiatives Librarian and Assistant Professor, …

Factors That Lead To The Decline Of Mental Health Among Collegiate Athletes And Tools Administrators Can Use To Better Support Them, Abreanna Lake

Counseling Psychology | Master's Theses

This paper is an exploration of the athletic community that uncovers how stigma, pressure to perform well, and external factors all contribute to the stagnant relationship between athletes and mental health. With stigma being a major influence in inhibiting athletes from feeling comfortable; it has led to college athletes navigating their emotional distress by themselves in order to maintain their image of being indestructible and indomitable. This vulnerable population having to struggle in silence has led to depression, anxiety, substance abuse, disordered eating, and suicidality in some college athletes. Luckily, the National Collegiate Athletic Association (NCAA) and a few college …