Digital Commons Network^™

The Effect Of Culture And Society On Postpartum Depression: Impacts Observed In India And America, Roma Agarwal

The Crown: Syracuse Honors Research Journal

No abstract provided.

E Hui Me Ke Kaiāulu: To Connect With The Community, Heather Kayleen Bartlett

Dissertations and Theses

Urban planning literature contains a wealth of knowledge on community engagement as a crucial component of the planning process, yet there remains a notable gap in our understanding of best practices when it comes to sustaining community involvement for ongoing plan implementation. The County of Hawai'i, has charted a unique course through the establishment of Action Committees which serve as an intermediary to uplift grassroots implementation efforts while remaining closely entwined with County resources and processes. This interplay provides a unique case study that results in somewhat of an "identity crisis": Action Committees do not have the autonomy of external …

Breaking Barriers: The All-American Girls Professional Baseball League And The Battle For Gender Equality, Lily Newman

The Crown: Syracuse Honors Research Journal

No abstract provided.

Hydrofoil: The History Of A Cold War Weapon-Turned Personal Recreation Gadget, Yida "Rick" Li

The Crown: Syracuse Honors Research Journal

No abstract provided.

The Crown, Complete Issue - V1, The Crown

The Crown: Syracuse Honors Research Journal

No abstract provided.

Screening For Uterine Fibroids In Black Women, Winnie N. Kagendo

Doctor of Nursing Practice (DNP) Projects

Background: Uterine fibroids are benign growths in the uterine muscle that affect around 70% of women. Black women have a higher risk, with three times the likelihood of developing fibroids compared to other races.

Problem: The issue of uterine fibroids continues to be poorly addressed in healthcare settings. Black women continue to be particularly adversely impacted by this problem. There is a lack of better screening methods, leading to late detection and limited treatment options for those hoping to maintain fertility.

Methods: A quality improvement project was implemented at a primary care clinic in Loma Linda, California, using the Uterine …

Targeting Macrophytes: Increased Water Quality Through Optimized Vegetation Considerations For Constructed Wetlands, Austin Mcbrady

Masters Theses (Archived)

This study of constructed wetland design investigated relationships between macrophyte species selection and planting density for water quality improvement. A lab-scale wetland was compared against a pilot-scale wetland in San Antonio, Texas at Mitchell Lake to measure differences in effluent water quality improvement using three native macrophyte species. Using a novel, two-phase method, a targeting macrophyte was identified from among other species based on its marked capability for improving water quality factors, then was planted in varied majority densities to compare differences in treatment effectiveness. The results of this study showed that this complimentary approach to wetland design displayed significant …

Utility Of Bariatric Surgery In The Remission Of Type 2 Diabetes Mellitus, Christine Ercoline, Alyssa Bower, Corinne Singh

Physician Assistant Capstones, 2020-current

Objective: Assess whether bariatric surgery is more effective than lifestyle modification and medication in the long-term reduction of hemoglobin A1c (HbA1c) and fasting plasma glucose among obese adults with type 2 diabetes mellitus. Design: Systematic literature review. Methods: A PubMed search was performed utilizing the terms bariatric surgery, type 2 diabetes and remission. In PubMed the following limits and terms were used: published in the last 10 years, humans, full text, clinical trial, randomized control trial, and English. Results: An analysis of three randomized control trials (RCTs) supports bariatric surgery as a modality to induce the remission of type 2 …

Congratulations, Library Graduates, University Of Dayton

University Libraries Blog Archive

The University Libraries rely on student employees to help meet the University’s research, teaching and learning needs. The faculty and staff in the University Libraries honor, thank and congratulate the student staff listed below, who graduate this week.

A Retrospective Survey Of Joint Mobilization Utilization During Clinical Internship Of Silliman University Physical Therapy Alumni, Lily Ann Bautista, Regina Bautista, Andrei Altavas, Leanna Bautista

Philippine Journal of Physical Therapy

Introduction: Physical therapy interns of Silliman University reported limited exposure to the application of joint mobilization techniques during their clinical internship training program. The study aimed to determine whether joint mobilization is utilized in physical therapy internships, including the barriers and challenges affecting its use. The study described (1) the interns' self-reported knowledge and awareness of the benefits, principles, type, and indications of joint mobilization, (2) the use of joint mobilization with regards to practice settings and locations, (3) the interns' self-assessment of competency to perform joint mobilization techniques after graduation, and (4) the barriers to increased utilization during clinical …

Tipping The Mesoscales: Advances In Multipeak Bragg Coherent Diffraction Imaging, J. Nicholas Porter

Theses and Dissertations

Material failure begins with strain between atoms and cascades upward into macroscopic damage such as cracks. Therefore, our ability to predict (and therefore prevent) material failure is largely limited by our understanding of this process. This understanding, however, has been impeded by the difficulty of directly observing such phenomena. In this thesis, I discuss recent advances in Bragg coherent diffraction imaging (BCDI) which produce three-dimensional, mesoscopic images of interior strain in microcrystals. In particular, I present a novel algorithm, based on the concept of cyclic-constrained optimization (CCO), for the rapid, coupled reconstruction of a microcrystal from multiple Bragg diffraction patterns. …

Pkcε Activator Protects Hippocampal Microvascular Disruption And Memory Defect In 3×Tg-Alzheimer's Disease Mice With Cerebral Microinfarcts, Huaixing Wang, Zongxiu Zhang, Jarin Hongpaisan

Center for Translational Medicine Faculty Papers

BACKGROUND: Current evidence suggests that microvessel disease is involved in Alzheimer's disease (AD). Cerebrovascular disease correlates with cardiovascular disease and is complicated in ≈40% of AD patients. The protein kinase C (PKC) ε activator DCPLA can stimulate human antigen (Hu) R that prevents degradation and promotes the translation of mitochondrial Mn-superoxide dismutase (MnSOD) and vascular endothelial growth factor-A (VEGF) mRNAs.

METHODS: To induce brain microinfarcts, we injected triple transgenic (3×Tg) and wild-type (WT) control mice with microbeads (20 μm caliber) into common carotid arteries, with or without the DCPLA-ME (methyl-ester) for 2 weeks. After water maze training, mice at 16 …

Acidosis-Mediated Increase In Ifn-Γ-Induced Pd-L1 Expression On Cancer Cells As An Immune Escape Mechanism In Solid Tumors, Philipp Knopf, Dimitri Stowbur, Sabrina H L Hoffmann, Natalie Hermann, Andreas Maurer, Valentina Bucher, Marilena Poxleitner, Bredi Tako, Dominik Sonanini, Balaji Krishnamachary, Sanhita Sinharay, Birgit Fehrenbacher, Irene Gonzalez-Menendez, Felix Reckmann, David Bomze, Lukas Flatz, Daniela Kramer, Martin Schaller, Stephan Forchhammer, Zaver M Bhujwalla, Leticia Quintanilla-Martinez, Klaus Schulze-Osthoff, Mark D Pagel, Marieke F Fransen, Martin Röcken, André F Martins, Bernd J Pichler, Kamran Ghoreschi, Manfred Kneilling

Faculty, Staff and Student Publications

Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L1) expression on cancer cells is mainly regulated by Interferon-gamma (IFN-γ), which induces T cell exhaustion and enables tumor immune evasion. In this study, we demonstrate that acidosis, a common characteristic of solid tumors, significantly increases IFN-γ-induced PD-L1 expression on aggressive cancer cells, thus promoting immune escape. Using preclinical models, we found that acidosis enhances the genomic expression and phosphorylation of signal transducer and activator of transcription …

Fabrication And Characterization Of Flexible Microelectrode Arrays On Kapton Polyimide For Implantable Spinal Cord Stimulation Applications, Nabil Jamhour

Theses and Dissertations

Recent advances in spinal cord stimulation (SCS) technology have made a significant impact in the treatment of chronic pain which is a prevalent issue amongst 20% of the population in developed nations. A few medical device manufactures have developed SCS devices that have been studied in clinical environments and reported to be effective and safe for commercial use. However, the current SCS devices available are bulky, rigid, and still present infection, fibrosis, discomfort, pulse delivery challenges and other concerns for patients. In this study, flexible electrodes processed on Kapton® polyimide films by physical vapor and inkjet deposition are fabricated and …

College Student Attitudes Toward Student-Athlete's Ability To Profit From Name, Image, And Likeness (Nil), Daniel G. Panzano

Honors Theses

Since the recent passing of legislation allowing student-athletes to profit from their own personal brands and sponsorships (Name, Image, and Likeness; NIL), there has been very little research. The purpose of this study was to measure the attitudes and support students have towards the financial compensation of their student-athlete counterparts. The researchers surveyed 67 Coastal Carolina University students. Using a quantitative study, data was gathered pertaining to the opinions toward NIL, feelings of team affiliation, and demographic information. Statistically significant differences were found toward some elements of NIL and gender, major, and academic year. A statistically significant correlation was also …

Students’ Perception Of Possibilities Of Using Business Process Modeling To Improve Organizations, Małgorzata Oleś-Filiks

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: The main aim of this article is to analyze the knowledge of the students – future users of these systems – of the awareness of the use and possibilities of using business process modeling in improving the organization. Design/Methodology/Approach: The research was carried out using the CAWI method. The questionnaire prepared for this purpose was first verified with the participation of experts in the field of business process modeling and then made available to students to fill in on the servers of the Faculty of Management of the University of Warsaw. The study concerned general knowledge of concepts related …

Moral Licensing: Causes And Consequences In Public Administration, Atefeh Sodeiri Javadi

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: Voluntary deviation from self-controlling which is known as moral licensing, individuals justify their immoral and counterproductive behavior depending on past creditable behaviors, without worrying about the loss of their reputation and esteem. The aim of the study is to identify the causes and consequences of moral licensing. Design/Methodology/Approach: The paradigm of the study is interpretive; its approach is qualitative and its strategy is grounded theory with emergent approach. In this regard, indepth, semi-structured interviews were conducted with managers and employees of public administration in northeastern Iran. Findings: The result of analysis of 17 interviews showed 119 codes, 63 concepts, …

Investigating And Targeting Iron Metabolism In Pseudomonas Aeruginosa And Klebsiella Pneumoniae, Zachary Scott

Theses & Dissertations

Antimicrobial resistance is an incredibly pressing issue in modern medicine. Because of that many researchers are pursuing just as many avenues for treatment of these pathogens. However, due to the nature of bacteria many of these methods are stop gaps and the bacteria can develop typically within years of their deployment. Therefore, more robust methods of treating infections of antimicrobial resistant bacteria that are difficult or impossible to develop resistance to are required. To produce this effect the treatment would need to target and alter or inhibit functions or structures essential to the bacteria that could not be altered, additionally …

Examining Caf Heterogeneity In Pancreatic Cancer, Nidhi V. Dwivedi

Theses & Dissertations

This thesis delves into the complexities of pancreatic ductal adenocarcinoma (PDAC) and its microenvironment. This study centers on unraveling the heterogeneity of pancreatic cancer-associated fibroblasts (CAFs) using a panel of patient-derived pancreatic fibroblasts. Additionally, it delves into the realm of G-protein-coupled receptors (GPCRs), with a specific emphasis on the Endothelin receptors (ETAR and ETBR), all within the context of PDAC.

A key achievement is the development of immortalized patient-derived pancreatic fibroblasts (iPDPFs), replicating CAF heterogeneity in PDAC. The iPDPFs were able to recapitulate the PDAC CAF heterogeneity, plasticity, and the overlapping nature of the tumor stroma. Functional characterization of iPDPFs …

Towards A Mode Of Action For The Anti-Schistosomal Aryl Hydantoins, Thomas Schulze

Theses & Dissertations

Schistosomiasis is a significant human disease caused by the helminth parasite Schistosoma mansoni. Praziquantel remains the only clinically used treatment, yet it is rapidly metabolized and only effective against the adult stage worm infection. Ro 13-3978 (AR02) is a potent antischistosomal compound with activity against multiple S. mansoni life stages; however, it manifests anti-androgenic activity. Additionally, the mechanism of action for worm clearance remains unknown. The structure of Ro 13-3979 was used to generate optimized derivatives, including AR102, that show increased potency towards worms, reduced off-target anti-androgen effects, and extended half-life thereby increasing the feasibility for a single-dose curative treatment. …

Synergetic Signaling Between The Chlamydia Secreted Effectors Tarp And Tmea Regulates Actin Kinetics And Efficient Entry, Matthew Romero

Theses & Dissertations

Chlamydia trachomatis is both the leading cause of non-congenital preventable blindness in developing nations and the leading source of bacterial sexually transmitted infections. As an obligate intracellular pathogen, Chlamydia has an absolute requirement on gaining entry into its host, which is accomplished by manipulating the host actin cytoskeleton to assemble engulfment structures that drive pathogen entry. In support of this, Chlamydia secretes the effectors TarP and TmeA via a type-III secretion system, whose respective signaling outputs operate synergistically to generate rapid actin kinetics and efficient pathogen engulfment. Rapid actin recruitment characteristic of invading Chlamydia is derived from a collaborative interaction …

A Mixed Methods Study Of Physical Activity In The Intensive Care Unit And Post-Intensive Care Unit Hospital Stay: Patient Characteristics, Symptom Burden, And Experiences Of Postoperative Adults, Christina Bach

Theses & Dissertations

Background: Physical activity (PA) beginning early in the intensive care unit (ICU) can reduce adverse outcomes commonly experienced by individuals after ICU discharge. Patient-centered approaches to PA in the ICU and reliable activity evaluations are essential for understanding PA's impact on patient outcomes.

Objective: This dissertation sought to evaluate patient-related factors associated with PA in the ICU and post-ICU hospital stay.

Methods: The purpose of the dissertation was to conduct: 1) a concept analysis to define ICU survivorship and identify critical care aspects important for patient recovery; 2) an integrative literature review to assess early mobility (EM) interventions with physical, …

Role Of The Ganglioside Gd2 And Its Biosynthetic Enzyme Gd3 Synthase In Prostate Cancer Tumorigenesis, Aaqib Bhat

Theses & Dissertations

Despite significant advancements in managing localized prostate cancer (PC), which have notably increased survival rates, advanced PC continues to be a leading cause of cancer- related fatalities. The discovery of new pathways that can be targeted to inhibit tumor growth in PC could pave the way for innovative treatment strategies. The disialylganglioside GD2 is an FDA-approved target for antibody therapies in neuroblastoma and has not been extensively studied in the context of PC. The work done in this thesis reveals that GD2 is present on a minor subset of PC cells in certain patients and is more prevalent in metastatic …

Power And Politics In The Media: The Year In C-Span Archives Research, Volume 9, Robert X. Browning

The Year in C-SPAN Archives Research

Power and Politics in the Media: The Year in C-SPAN Archives Research, Volume 9 features articles from multiple disciplines that use the C-SPAN Video Library to explore recent controversies in American politics. Topics covered include Supreme Court nominations, Supreme Court oral arguments, rhetoric on disasters and COVID-19, and the effect of clothing on the approval of women in power. What unites these topics is the unique use of the video record of C-SPAN to explore the intersections of politics, power, rhetoric, and the media in the contemporary United States. Written in accessible prose, this volume showcases some of the most …

[Excerpt From] Building A Culture Of Ownership In Healthcare (3rd Ed.), Joe Tye, Bob Dent

Sigma Publications: Book Excerpts

This item record pertains to an excerpt from Building a Culture of Ownership in Healthcare, 3rd Edition, which is provided free of charge by the publisher.

About this book:

In the aftermath of the pandemic, preexisting challenges in healthcare organizations have intensified. Stress, burnout, staffing shortages, and even the erosion of trust in organizational leadership are pressing issues that need solutions.

Using construction as their metaphor, authors Joe Tye and Bob Dent make a compelling case that a healthcare organization's Invisible Architecture—a foundation of core values, a superstructure of organizational culture, and the interior finish of workplace attitude—is …

Video Art In The Gallery Space, Juliet Wang, Matthew Thompson

Honors Thesis

The gallery space poses several challenges for incorporation of audiovisual or video elements, including offset entrances, lack of time investment, sound bleed, and light bleed. In order for an audiovisual work to be well optimized for the gallery space, ideally the artist should not only find ways around as many of these “challenges” as possible but also to embrace them and have the work be stronger because of these challenges.

Functionalized Surface Of Plga Nanoparticles In Thermosensitive Gel To Enhance The Efficacy Of Antibiotics Against Antibiotic Resistant Infections In Endodontics: A Randomized Clinical Trial, Mona Arafa, Hadeel Moussa, Mohamed Medhat Kataia

Pharmacy

Enterococcus faecalis plays the key role in endodontic infections and is responsible for the formation of biofilm on dentin, which causes a resistance against periradicular lesions treatment, consequently the aim of this study is to use nanoparticles entrapping anibacterial agents coated with chitosan that in authors previous study showed a successful in vitro biofilm inhibition, additionally incorporated in thermoresponsive gel.to benefit nanoparticles` small size, and the positive charge of their surfaces that binds with the negatively charged surface of bacterial cell causing its destruction, in addition to the sustained release pattern of the drug based nanoparticles in gel. Therefore, Ciprofloxacin …

Understanding The Relationship Between Narcissism And Political Orientations In College-Aged Adults, Sabrina Richards

Undergraduate Honors Theses

When you try to guess someone’s political beliefs, you probably look towards the usual culprits: race, gender, education, religion, age, marital status, and more. Have you ever tried looking at their narcissistic tendencies? There are seven different types of narcissism, and in a study conducted by Peter K. Hatemi and Zoltan Fazekas in 2018, it was revealed that there is a relationship between an adult’s narcissistic personality traits and their political orientations. It was observed that entitlement narcissism is associated with more conservative political orientations, while exhibitionism narcissism is associated with more liberal political orientations. However, there is a lack …

From House Party To World Dominance: Celebrating 50 Years Of Hip Hop: A Bibliography, Cassandra Chaney

Journal of Hip Hop Studies

In 2023, the culture celebrated the 50th birthday of Hip Hop. While there is an ongoing argument of when Hip Hop started, Hip Hop culture marked Clive “DJ Kool Herc” Campbell’s legendary 1973 party at 1520 Sedgwick Avenue in the Bronx, NY as the day to commemorate its humble beginnings. This work provides a bibliographical list of published articles, interviews, book reviews, forthcoming books, and live performances from various artists that made a major impact on Hip Hop. In particular, the bibliography highlights the mark that Hip Hop has made on fashion, the economy, language, and the unique contributions that …

Foreword, Courtney Terry

Journal of Hip Hop Studies

Foreword for volume 10 issue 1.