Digital Commons Network^™

Multiomics For Elucidating The Pathogenesis Of Liver Cancers: A Transcriptomic Signature Of Fibrolamellar Hepatocellular Carcinoma, David R. Requena Anicama

Student Theses and Dissertations

Fibrolamellar Hepatocellular Carcinoma (FLC) is a rare liver cancer affecting adolescents and young adults. Almost all FLC patients present a somatic heterozygous deletion in chromosome 19p13.12, producing the chimeric transcript DNAJB1::PRKACA, which is sufficient to drive FLC in mice. Nevertheless, a few cases of liver tumors presenting FLC histopathological characteristics but missing the chimera DNAJB1::PRKACA have been reported. They have either 1) a lack of protein expression of PRKAR1A, 2) the presence of the chimeras ATP1B1::PRKACB or ATP1B1::PRKACA, or 3) a chromosome gain of PRKACA or loss of PRKAR2A, accompanied with inactivation of BAP1. A few RNA-seq studies compared FLC …

Importance Of Spending Time In Nature, Peyton M. Daniel

A with Honors Projects

No abstract provided.

Data-Driven Dynamic Motion Planning For Practical Fes-Controlled Reaching Motions In Spinal Cord Injury, Derek N.N. Wolf, Antonie J. Van Den Bogert, Eric M. Schearer

Mechanical Engineering Faculty Publications

Functional electrical stimulation (FES) is a promising technology for restoring reaching motions to individuals with upper-limb paralysis caused by a spinal cord injury (SCI). However, the limited muscle capabilities of an individual with SCI have made achieving FES-driven reaching difficult. We developed a novel trajectory optimization method that used experimentally measured muscle capability data to find feasible reaching trajectories. In a simulation based on a real-life individual with SCI, we compared our method to attempting to follow naive direct-to-target paths. We tested our trajectory planner with three control structures that are commonly used in applied FES: feedback, feedforward-feedback, and model …

Evsc 610-102: Environmental Chemical Science And Ene 663, Lijie Zhang

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Engram, Vol. 2 2023, Portland State University. School Of Art + Art History + Design

Engram: A Journal of Art History Student Writing

• Editorial Foreword, Hailey Brink

• Reading Queerness in Hilma af Klint’s Diagrammatic Abstractions, Ana Bane

• Opus Anglicanum and May Morris: An Art Historical Study in Meaning Through Time, Rose Caughie

• The Development of El Greco’s Technique Through Mary Magdalen, Natalie Dunlap

• The Great Gold Belt Buckle of Sutton Hoo: A Look at Scandinavian Influence on Anglo-Saxon Style, Elizabeth Hines

• The Late Avar Treasure of Nagyszentmiklos, Ashley Hood

• Demystifying the Authorship of Artemisia Gentileschi’s 1622 Susanna and the Elders Aaron, Lindsay Wilson

• Research-Based Fiction: Redemption in Ruins, John Hooley

Human Rights And Divine Holiness, Kevin Vallier

Philosophy Faculty Publications

Theists commonly hold that God endows humans with rights. Standard explanations draw on natural law theory or divine command theory. However, the natural law account does not give God a central role in explaining our rights, and the divine command account does not assign human nature a significant explanatory role. A successful theistic explanation of human rights must meet three conditions: (1) God must directly explain human rights; (2) human nature must also directly explain human rights; (3) this dual contribution must explain why morality forbids rights violations by grounding the deontic reasons associated with rights. I propose a holiness …

Disaster Relief And Humanitarian Logistics: Three Essays, Peter H. Imbriale

2023

The increased frequency and impact of natural disasters and other humanitarian crises—including events such as the COVID-19 pandemic—makes studying disaster relief and recovery particularly important. One relevant area of research in this space is humanitarian logistics. This dissertation provides insights into disaster relief logistics by exploring the government’s role in humanitarian logistics, examining the government’s efforts to address COVID-19 medical supply chain challenges, and determining how to lessen the impact of supply chain bottlenecks from unwanted post-disaster donations. Chapter one (sole-authored) is a literature review of the role of governments in humanitarian logistics. Although governments are vital stakeholders in nearly …

Using Data And Evidence To Improve Quality Of Life For Patients With Alzheimer’S Disease, Ying Wang

2023

As an irreversible, progressive brain disorder, Alzheimer’s disease (AD) imposes a severe burden upon patients and their caregivers, as well as the healthcare system. Of the ten leading causes of death in the United States, Alzheimer’s disease is the only one without a pharmacological intervention that has been proven to cure or delay the onset of the disease. Aging is the primary risk factor contributing to Alzheimer’s disease in the elderly. With an aging population that continues to grow, the challenges for the healthcare system surrounding AD become more and more serious. My dissertation aims to contribute to a better …

Digital Nudges: An Investigation Of Both Consumer And Designer Perspectives, Ja-Naé Duane

2023

This dissertation explores how knowledge of digital nudges impacts consumer decisions, and how consumer preferences based on that knowledge impacts design decisions. Paper 1 presents a systematic narrative literature review on the evolution of digital nudge literature. This investigation uncovers several themes and provides a basis for a revised definition of digital nudges and a taxonomy wheel of digital nudges. Paper 2 (co-authored with Jeffrey Livingston, Jonathan Ericson, and Patrick McHugh) investigates how knowledge about digital nudges impacts consumer preferences to have them within the digital experiences they use. This paper highlights how knowledge of digital nudges impact consumer online …

Improving Workplace Judgments By Reducing Noise: Lessons Learned From A Century Of Selection Research, Scott Highhouse, Margaret E. Brooks

Management Faculty Publications

Some assert that noise (i.e., unwanted variance) is the most neglected yet most important source of error in judgment. We suggest that this problem was discovered nearly 100 years ago in the area of personnel selection and that a century of selection research has shown that noise can be demonstrably reduced by structuring the process (i.e., decomposing the component parts, agreeing on standards, and applying those standards consistently) and by aggregating judgments independently. Algorithms can aid significantly in this process but are often confused with methods that, in their current form, can substantially increase noise in judgment (e.g., artificial intelligence …

Comparison Of Groundwater Chemistry And Associated Biodiversity Of Sulfidic Karst Habitats In Southcentral Kentucky, Kendall Wheeler

Mahurin Honors College Capstone Experience/Thesis Projects

In most ecosystems, primary production is conducted by plants or photosynthetic microbes; however, extremophilic sulfur-oxidizing bacteria can use hydrogen sulfide gas (H2S) as an electron donor to produce metabolic energy in a type of metabolism called chemoautotrophy. These ecosystems are a prominent feature of some karst landscapes, and two have been observed in the Mammoth Cave system, Sulphur River in Parker Cave and Marianne’s Pass in Mammoth Cave National Park respectively.

Sulfidic water is ubiquitous in southcentral Kentucky and is strongly associated with hydrocarbon deposits. This oil boom of the 1880s in this region predates most environmental regulation and records …

Planning Committee 2023 Annual Report, Planning Committee, College Of Public Affairs And Community Service, University Of Nebraska At Omaha

Publications

The planning committee of the Nebraska Legislature is charged with establishing and maintaining a future focus on the priorities of the State. Its responsibility is to assure continuity of policy to achieve long term goals. The committee will do so by collecting and analyzing data, identifying priorities, setting long term goals, and establishing benchmarks

The Exit Theory Of Judicial Appraisal, William J. Carney, Keith Sharfman

Fordham Journal of Corporate & Financial Law

For many years, we and other commentators have observed the problem with allowing judges wide discretion to fashion appraisal awards to dissenting shareholders based on widely divergent, expert valuation evidence submitted by the litigating parties. The results of this discretionary approach to valuation have been to make appraisal litigation less predictable and therefore more costly and likely. While this has been beneficial to professionals who profit from corporate valuation litigation, it has been harmful to shareholders, making deals costlier and less likely to be completed.

In this Article, we propose to end the problem of discretionary judicial valuation by tracing …

From Tether To Terra: The Current Stablecoin Ecosystem And The Failure Of Regulators, Mary E. Burke

Fordham Journal of Corporate & Financial Law

The Tether controversy and Terra crash have placed stablecoins in the regulatory spotlight. Stablecoins are often portrayed as posing systemic risks to financial markets, with some pundits labelling them “the villain of the finance world.” Global regulatory bodies, namely the International Monetary Fund (IMF) and the Bank of International Settlement (BIS), and political leaders, including the Biden Administration, have all called for stablecoin regulation. These officials allege that stablecoins’ structure, combined with their exponential growth, pose a unique risk to global markets. Before the May 2022 Terra crash, government reports superficially treated stablecoins by exclusively focusing on asset-backed coins. Post …

Critical Teaching Behaviors: Defining, Documenting, And Discussing Good Teaching., Lauren Cornejo Barbeau, Claudia Cornejo Happel, Nancy L. Chick

Publications

What does “good” teaching mean, and how can we know it when we see it? Perhaps you have grappled with these questions at some point in your career, either as an instructor wanting to document or grow your teaching effectiveness or as a peer or administrator trying to provide guidance to or assess the teaching of others.This book serves three purposes: a condensed, evidence-based guide to effective teaching; a resource on creating a focused teaching narrative and teaching portfolio; and a toolkit that equips faculty to conduct peer observations, student midterm feedback, and productive conversations related to teaching.

The first …

Evolution And Expiration: Using Ruin As Critical Medium, Matthew Gilligan

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Almajiri Health; A Scoping Review On Disease, Health Literacy And Space For Participatory Research, Muzzammil Imran Muhammad

Yale Medicine Thesis Digital Library

Introduction

Almajirai are male children who leave the care of their parents to learn the Qur’an and study Islam under the tutelage of a Mallam or Imam at a Tsangaya. Almajiranci refers to the system of education based on this relationship between almajiri and mallam, and which was the dominant mode of education in precolonial Hausaland – Northern Nigeria and Southern Niger. This system remains widespread and popular in both countries. In recent years, discourse around almajirai has featured prominently in media from and about this region, and has associated almajiranci with non-participation in formal education, abuse, poverty, and underdevelopment. …

Radiomics: A Methodological Guide And Its Applications To Acute Ischemic Stroke, Emily Avery

Yale Medicine Thesis Digital Library

The field of radiomics provides a quantitative approach to medical imaging, wherein a large number of features extracted from medical images are used to detect clinically relevant information that is invisible to the naked eye. This increasingly prevalentmethodology has facilitated improvements in the speed and efficacy of clinical decision-making across specialties. One area where radiomics can make a particular impact is acute stroke imaging. As “time is brain” in acute stroke triage, automated tools for patient evaluation have significant potential to improve outcomes by providing timely, objective data. The present work aimed to create radiomics models from admission CT angiographic …

Structural And Magnetic Properties Of Heusler Alloys: Fecrmn1-Xvxal (X = 0, 0.5, 0.75), Jax Wysong, Gavin Baker

The Journal of Undergraduate Research

Heusler alloys are important to investigate due to their multiple interesting properties including half-metallicity and spin-gapless semi conductivity. Materials exhibiting these properties are desired for spin-transport-based devices. These devices provide the storing and delivering of information through the utilization of the spin property of electrons. The magnetic and electronic band properties of these alloys can be modified by tuning the elemental composition. This work investigates structural and magnetic properties of the three Heusler alloys FeCrMnAl, FeCrMn_0.5V_0.5Al, and FeCrMn_0.25V_0.75Al. It was found that all three alloys crystallize in cubic crystal structure with an …

Eye Lens Β-Crystallins Are Predicted By Native Ion Mobility-Mass Spectrometry And Computations To Form Compact Higher-Ordered Heterooligomers, Amber D. Rolland, Takumi Takata, Micah T. Donor, Kirsten J. Lampi, James S. Prell

Faculty Publications - Department of Biological & Molecular Science

Eye lens crystallin proteins maintain the refractive properties of the lens but are not replaced after denucleation. Rolland et al. use native ion mobility-mass spectrometry, kinetics experiments, and computations to reveal that b-crystallins form heterodimers. These likely assemble into compact heterooligomers that enable the very high protein concentrations found in lens tissue.

Defining Sagittal Plane Gait Mechanics And Joint Loading In People With Marfan Syndrome, Justin Melan Pol

Theses and Dissertations--Biomedical Engineering

Marfan syndrome (MFS) is a genetic condition that is associated with altered muscle composition, which leads to muscle dysfunction. People with MFS exhibit high instances of lower extremity (LE) joint pain that inhibits their ability to perform activities of daily living, such as walking. Despite these detrimental impacts of MFS, there have been no attempts to characterize the effects of MFS on LE joint loading and health during walking that are associated with LE pain and dysfunction. As people with MFS exhibit a high incidence rate of osteoarthritis (OA), the need to understand the potential alterations in LE extremity mechanics …

Quantitative Microbial Risk Assessment (Qmra) For Urban Stormwater Reuse After Treatment Through A Bioretention System, Isaac Oluk

Theses and Dissertations--Civil Engineering

Bioretention, also referred to as a stormwater biofilter, is an extensively used low-impact development technology for both stormwater management and water quality gains. However, little attention has been paid to the acceptability and uncertainty of human health risks associated with the treatment performance of bioretention filter media, and non-potable water reuse scenarios to guide decision-making and system design. This study uses bioretention mechanistic modeling paired with quantitative microbial risk assessment (QMRA) under uncertainty to evaluate human health risks from two reference pathogens – Campylobacter jejuni and Cryptosporidium. Consumption of irrigated green salad, consumption of raw green salad washed with effluent, …

Prediction Of Chlorine And Disinfection Byproduct Concentration In Water Distribution Systems Using Kypipe And Tthm Regression Models: Application To Two Systems In Kentucky, Yogesh Gautam

Theses and Dissertations--Civil Engineering

The main objective of this research is to study if the hydraulic and water quality models can be used for water quality analysis of chlorine decay and TTHM formation at various locations across a water distribution system. This is particularly important because it is not always easy or economical to take multiple field samples and analyze them in the laboratory. In this study, models of two different water distribution systems (one more urban and efficiently managed system located in a relative flat topography, and other more rural and less efficiently managed system located in a mountainous topography) were developed in …

Practical Ai Value Alignment Using Stories, Md Sultan Al Nahian

Theses and Dissertations--Computer Science

As more machine learning agents interact with humans, it is increasingly a prospect that an agent trained to perform a task optimally - using only a measure of task performance as feedback--can violate societal norms for acceptable behavior or cause harm. Consequently, it becomes necessary to prioritize task performance and ensure that AI actions do not have detrimental effects. Value alignment is a property of intelligent agents, wherein they solely pursue goals and activities that are non-harmful and beneficial to humans. Current approaches to value alignment largely depend on imitation learning or learning from demonstration methods. However, the dynamic nature …

Hypogene Speleogenesis In The Grand Canyon; Observational, Mineralogical, And Geochemical Investigations From The Bopper Cave System, Sierra Heimel

Theses and Dissertations--Earth and Environmental Sciences

One of the most prominent features of the Grand Canyon is the iron-stained Redwall Limestone, which has been documented to contain extensive cave systems with significant storage potential in the karstic Redwall-Muav (R-M) aquifer. The hydrogeologic relationships between the R-M aquifer and cave formation in the Grand Canyon via descending (epigenic) surface waters have been well documented. However; the potentially large role of deeply sourced (hypogenic) waters rising from depth in relation to cave formation is poorly understood. The Bopper Cave System (BCS) is a relict feature of the ancient abandoned hydrologic system at Grand Canyon and displays unique network …

Field Tests Of A Uav-Compatible Spectrometer To Evaluate Its Suitability For Detailed Soil Radon Potential Mapping, Alexandria Briahnne Thomas

Theses and Dissertations--Earth and Environmental Sciences

As part of ongoing research on radionuclide mapping and radon hazard characterization, field tests were performed to evaluate the suitability and limitations of a UAV-compatible gamma spectrometer. To date, this data set includes completed stationary data collection, mobile ground collection, multi-level UAV flights over a known material transition, as well as redundant ground and multi-level UAV data collection over a relatively uniform area. Total counts were used as a measure of soil radionuclide levels for our data collected above background. Although our test sites were in regions underlain by bedrock with high indoor radon levels, uranium counts were barely above …

Closing The Modern Seismic Gap Along The Teton Fault Via Seismic Mapping Of Mass Transport Deposits In Jackson Lake, Wy, Callia Jacqueline Cortese

Theses and Dissertations--Earth and Environmental Sciences

Terrestrial paleoseismological records along the Teton fault have historically indicated two-to-three major post-Pinedale (~14 ka) earthquake events, leaving an unresolved 6-9 m offset along the modern scarp. Recent studies of Jenny Lake have augmented this record, but the triggering mechanism is still equivocal until new paleo-earthquake records are developed. The earthquake record of the Teton fault is complicated by quiescence from ~5 ka to present, demonstrating the need for additional paleoseismic investigations. Compressed, high-intensity radar pulse (CHIRP) reflection data from Jackson Lake indicates multiple potentially seismically-induced mass transport deposits (MTDs). At least six MTD Groups representing chronostratigraphic intervals were interpreted …

The Appalachian System Of Basins And Platforms As A Tectonostratigraphic Analogue To The Barents Sea Shelf: Where Arctic Meets The Appalachians, Gustavo De Aguiar Martins

Theses and Dissertations--Earth and Environmental Sciences

Divided between Norway and Russia, the Barents Sea shelf (BSS) is an ~1.4 million km² Arctic province, containing significant hydrocarbon accumulations. However, much of the area is frontier, and geologic data are often restricted or unavailable. One strategy to mitigate lack of geologic data is the use of analogues from well-known, mature basins. Even though there have been attempts to use analogues to study the geology of the BSS, such use is limited. Moreover, no analogue, to my knowledge, has been capable of addressing the regional tectonostratigraphic development of the shelf as a whole.

In this research, the Appalachian …

Discovery Of The Middle Mantle Transition Zone (Mmtz) And Its Geodynamic Significance, Yuping Wang

Theses and Dissertations--Earth and Environmental Sciences

Global mantle discontinuities and mantle transition zones are crucial to the earth’s evolution. By employing K-Means clustering, which belongs to cluster analysis in machine learning (ML), on shear velocity variation data, we generate heterogeneity percentage profiles for three different global tomographic models (Models S362WMANI+M, SEMUCB-WM1, and S40RTS). Key cluster percentage shifts, which are observed at around 400 km, 650 km, 1050 km, 1500 km, and 2700 km, suggest global mantle discontinuities at corresponding depths. All profiles also indicate a global discontinuity in the lower mantle between 2200 km and 2600 km. The middle mantle transition zone (MMTZ), bounded between 1050 …

Applications Of Digital Terrain Modeling To Address Problems In Geomorphology And Engineering Geology, Sarah Johnson

Theses and Dissertations--Earth and Environmental Sciences

This dissertation uses digital terrain modeling and computational methods to yield insight into three topics: 1) evaluating the influence of glacial topography on fluvial sediment transport in the Teton Range, WY, 2) integrating regional airborne lidar, UAV lidar, and structure from motion photogrammetry to characterize decadal-scale movement of slow-moving landslides in northern Kentucky, and 3) applying machine learning methods to surficial geologic mapping.

The role of topography as a boundary condition that controls the efficiency of fluvial erosion in the Teton Range, Wyoming, was investigated by using existing lidar data to delineate surficial geologic units, geometrically reconstruct the depth to …