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2023

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Brain-Wide Correspondence Of Neuronal Epigenomics And Distant Projections, Jingtian Zhou, Zhuzhu Zhang, May Wu, Hanqing Liu, Yan Pang, Anna Bartlett, Zihao Peng, Wubin Ding, Angeline Rivkin, Will N Lagos, Elora Williams, Cheng-Ta Lee, Paula Assakura Miyazaki, Andrew Aldridge, Qiurui Zeng, J L Angelo Salinda, Naomi Claffey, Michelle Liem, Conor Fitzpatrick, Lara Boggeman, Zizhen Yao, Kimberly A Smith, Bosiljka Tasic, Jordan Altshul, Mia A Kenworthy, Cynthia Valadon, Joseph R Nery, Rosa G Castanon, Neelakshi S Patne, Minh Vu, Mohammad Rashid, Matthew Jacobs, Tony Ito, Julia Osteen, Nora Emerson, Jasper Lee, Silvia Cho, Jon Rink, Hsiang-Hsuan Huang, António Pinto-Duartec, Bertha Dominguez, Jared B Smith, Carolyn O'Connor, Hongkui Zeng, Shengbo Chen, Kuo-Fen Lee, Eran A Mukamel, Xin Jin, M Margarita Behrens, Joseph R Ecker, Edward M Callaway Dec 2023

Brain-Wide Correspondence Of Neuronal Epigenomics And Distant Projections, Jingtian Zhou, Zhuzhu Zhang, May Wu, Hanqing Liu, Yan Pang, Anna Bartlett, Zihao Peng, Wubin Ding, Angeline Rivkin, Will N Lagos, Elora Williams, Cheng-Ta Lee, Paula Assakura Miyazaki, Andrew Aldridge, Qiurui Zeng, J L Angelo Salinda, Naomi Claffey, Michelle Liem, Conor Fitzpatrick, Lara Boggeman, Zizhen Yao, Kimberly A Smith, Bosiljka Tasic, Jordan Altshul, Mia A Kenworthy, Cynthia Valadon, Joseph R Nery, Rosa G Castanon, Neelakshi S Patne, Minh Vu, Mohammad Rashid, Matthew Jacobs, Tony Ito, Julia Osteen, Nora Emerson, Jasper Lee, Silvia Cho, Jon Rink, Hsiang-Hsuan Huang, António Pinto-Duartec, Bertha Dominguez, Jared B Smith, Carolyn O'Connor, Hongkui Zeng, Shengbo Chen, Kuo-Fen Lee, Eran A Mukamel, Xin Jin, M Margarita Behrens, Joseph R Ecker, Edward M Callaway

Faculty, Staff and Student Publications

Single-cell analyses parse the brain’s billions of neurons into thousands of ‘cell-type’ clusters residing in different brain structures1. Many cell types mediate their functions through targeted long-distance projections allowing interactions between specific cell types. Here we used epi-retro-seq2 to link single-cell epigenomes and cell types to long-distance projections for 33,034 neurons dissected from 32 different regions projecting to 24 different targets (225 source-to-target combinations) across the whole mouse brain. We highlight uses of these data for interrogating principles relating projection types to transcriptomics and epigenomics, and for addressing hypotheses about cell types and connections related to genetics. …

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Single-Cell Dna Methylome And 3d Multi-Omic Atlas Of The Adult Mouse Brain, Hanqing Liu, Qiurui Zeng, Jingtian Zhou, Anna Bartlett, Bang-An Wang, Peter Berube, Wei Tian, Mia Kenworthy, Jordan Altshul, Joseph R Nery, Huaming Chen, Rosa G Castanon, Songpeng Zu, Yang Eric Li, Jacinta Lucero, Julia K Osteen, Antonio Pinto-Duarte, Jasper Lee, Jon Rink, Silvia Cho, Nora Emerson, Michael Nunn, Carolyn O'Connor, Zhanghao Wu, Ion Stoica, Zizhen Yao, Kimberly A Smith, Bosiljka Tasic, Chongyuan Luo, Jesse R Dixon, Hongkui Zeng, Bing Ren, M Margarita Behrens, Joseph R Ecker Dec 2023

Single-Cell Dna Methylome And 3d Multi-Omic Atlas Of The Adult Mouse Brain, Hanqing Liu, Qiurui Zeng, Jingtian Zhou, Anna Bartlett, Bang-An Wang, Peter Berube, Wei Tian, Mia Kenworthy, Jordan Altshul, Joseph R Nery, Huaming Chen, Rosa G Castanon, Songpeng Zu, Yang Eric Li, Jacinta Lucero, Julia K Osteen, Antonio Pinto-Duarte, Jasper Lee, Jon Rink, Silvia Cho, Nora Emerson, Michael Nunn, Carolyn O'Connor, Zhanghao Wu, Ion Stoica, Zizhen Yao, Kimberly A Smith, Bosiljka Tasic, Chongyuan Luo, Jesse R Dixon, Hongkui Zeng, Bing Ren, M Margarita Behrens, Joseph R Ecker

Faculty, Staff and Student Publications

Cytosine DNA methylation is essential in brain development and is implicated in various neurological disorders. Understanding DNA methylation diversity across the entire brain in a spatial context is fundamental for a complete molecular atlas of brain cell types and their gene regulatory landscapes. Here we used single-nucleus methylome sequencing (snmC-seq3) and multi-omic sequencing (snm3C-seq)1 technologies to generate 301,626 methylomes and 176,003 chromatin conformation–methylome joint profiles from 117 dissected regions throughout the adult mouse brain. Using iterative clustering and integrating with companion whole-brain transcriptome and chromatin accessibility datasets, we constructed a methylation-based cell taxonomy with 4,673 cell groups and 274 …

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Targeted Gene Expression Profiling Predicts Meningioma Outcomes And Radiotherapy Responses, William C Chen, Abrar Choudhury, Mark W Youngblood, Mei-Yin C Polley, Calixto-Hope G Lucas, Kanish Mirchia, Sybren L N Maas, Abigail K Suwala, Minhee Won, James C Bayley, Akdes S Harmanci, Arif O Harmanci, Tiemo J Klisch, Minh P Nguyen, Harish N Vasudevan, Kathleen Mccortney, Theresa J Yu, Varun Bhave, Tai-Chung Lam, Jenny Kan-Suen Pu, Lai-Fung Li, Gilberto Ka-Kit Leung, Jason W Chan, Haley K Perlow, Joshua D Palmer, Christine Haberler, Anna S Berghoff, Matthias Preusser, Theodore P Nicolaides, Christian Mawrin, Sameer Agnihotri, Adam Resnick, Brian R Rood, Jessica Chew, Jacob S Young, Lauren Boreta, Steve E Braunstein, Jessica Schulte, Nicholas Butowski, Sandro Santagata, David Spetzler, Nancy Ann Oberheim Bush, Javier E Villanueva-Meyer, James P Chandler, David A Solomon, C Leland Rogers, Stephanie L Pugh, Minesh P Mehta, Penny K Sneed, Mitchel S Berger, Craig M Horbinski, Michael W Mcdermott, Arie Perry, Wenya Linda Bi, Akash J Patel, Felix Sahm, Stephen T Magill, David R Raleigh Dec 2023

Targeted Gene Expression Profiling Predicts Meningioma Outcomes And Radiotherapy Responses, William C Chen, Abrar Choudhury, Mark W Youngblood, Mei-Yin C Polley, Calixto-Hope G Lucas, Kanish Mirchia, Sybren L N Maas, Abigail K Suwala, Minhee Won, James C Bayley, Akdes S Harmanci, Arif O Harmanci, Tiemo J Klisch, Minh P Nguyen, Harish N Vasudevan, Kathleen Mccortney, Theresa J Yu, Varun Bhave, Tai-Chung Lam, Jenny Kan-Suen Pu, Lai-Fung Li, Gilberto Ka-Kit Leung, Jason W Chan, Haley K Perlow, Joshua D Palmer, Christine Haberler, Anna S Berghoff, Matthias Preusser, Theodore P Nicolaides, Christian Mawrin, Sameer Agnihotri, Adam Resnick, Brian R Rood, Jessica Chew, Jacob S Young, Lauren Boreta, Steve E Braunstein, Jessica Schulte, Nicholas Butowski, Sandro Santagata, David Spetzler, Nancy Ann Oberheim Bush, Javier E Villanueva-Meyer, James P Chandler, David A Solomon, C Leland Rogers, Stephanie L Pugh, Minesh P Mehta, Penny K Sneed, Mitchel S Berger, Craig M Horbinski, Michael W Mcdermott, Arie Perry, Wenya Linda Bi, Akash J Patel, Felix Sahm, Stephen T Magill, David R Raleigh

Faculty, Staff and Student Publications

Surgery is the mainstay of treatment for meningioma, the most common primary intracranial tumor, but improvements in meningioma risk stratification are needed and indications for postoperative radiotherapy are controversial. Here we develop a targeted gene expression biomarker that predicts meningioma outcomes and radiotherapy responses. Using a discovery cohort of 173 meningiomas, we developed a 34-gene expression risk score and performed clinical and analytical validation of this biomarker on independent meningiomas from 12 institutions across 3 continents (N = 1,856), including 103 meningiomas from a prospective clinical trial. The gene expression biomarker improved discrimination of outcomes compared with all other systems …

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A New Method To Evaluate Pressure Distribution Using A 3d-Printed C2-C3 Cervical Spine Model With An Embedded Sensor Array, Frank Vrionis Dec 2023

A New Method To Evaluate Pressure Distribution Using A 3d-Printed C2-C3 Cervical Spine Model With An Embedded Sensor Array, Frank Vrionis

All Publications

Cervical degenerative disc diseases such as myelopathy and radiculopathy often require conventional treatments like artificial cervical disc replacement or anterior cervical discectomy and fusion (ACDF). When designing a medical device, like the stand-alone cage, there are many design inputs to consider. However, the precise biomechanics of the force between the vertebrae and implanted devices under certain conditions require further investigation. In this study, a new method was developed to evaluate the pressure between the vertebrae and implanted devices by embedding a sensor array into a 3D-printed C2-C3 cervical spine. The 3D-printed cervical spine model was subjected to a range of …

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Support, Networks, And Relationships: Findings From A Mixed-Methods Evaluation Of A Mentorship Programme For Early Career Women Researchers In Sexual And Reproductive Health And Rights, Muhammad Asim, Peter Muriuki Gatheru, Joy J. Chebet, Mehr G. Shah, Anna Thorson, Vanessa Brizuela Dec 2023

Support, Networks, And Relationships: Findings From A Mixed-Methods Evaluation Of A Mentorship Programme For Early Career Women Researchers In Sexual And Reproductive Health And Rights, Muhammad Asim, Peter Muriuki Gatheru, Joy J. Chebet, Mehr G. Shah, Anna Thorson, Vanessa Brizuela

Community Health Sciences

Low research output among women researchers in health research has been linked to inadequate mentorship opportunities for early career women researchers and particularly in sexual and reproductive health and rights (SRHR) field. Mentorship has been recognized as a contributor to strengthening research capacity and as beneficial for both mentors and mentees. Women researchers oftentimes experience negative impacts of organizational and structural gender inequities related to formal and informal mentoring. In 2020, the UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction at WHO launched a mentorship programme for early career SRHR women researchers from low- and …

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Drone Swarms In Adversarial Environment, Bhavana Sai Yadav Akula Dec 2023

Drone Swarms In Adversarial Environment, Bhavana Sai Yadav Akula

Theses

Drones are unmanned aerial vehicles (UAVs) operated remotely with the help of cameras, GPS, and on-device SD cards. These are used for many applications including civilian as well as military. On the other hand, drone swarms are a fleet of drones that work together to achieve a special goal through swarm intelligence approaches. These provide a lot of advantages such as better coverage, accuracy, increased safety, and improved flexibility when compared to a single drone. However, the deployment of such swarms in an adversarial environment poses significant challenges. This work provides an overview of the current state of research on …

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Optimal Route Planning Using Computer Simulation In The Context Of Distributor-To-Consumer Supply Network, Miriam Aguilera Nava Dec 2023

Optimal Route Planning Using Computer Simulation In The Context Of Distributor-To-Consumer Supply Network, Miriam Aguilera Nava

Open Access Theses & Dissertations

Effective route planning for distribution centers is a multifaceted challenge crucial tobusiness success, as it directly impacts time and cost savings while enhancing overall delivery efficiency. Oversight of proper planning can lead to problems and inefficiencies in the distribution process. Hence, this work undertakes a comparative experiment of two delivery strategies in a distributor-to-consumer supply network. While the first strategy investigates the delivery process by zip area, the second strategy considers the clustering of the areas for more streamlined delivery fulfillment. The effectiveness of the delivery process is gauged based on a set of metrics, including total distance traveled, average …

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Activity Patterns Of Whiptail Lizards (Aspidoscelis) Found In The Northern Chihuahuan Desert, Guillermo Alvarez Dec 2023

Activity Patterns Of Whiptail Lizards (Aspidoscelis) Found In The Northern Chihuahuan Desert, Guillermo Alvarez

Open Access Theses & Dissertations

Traditional lizard pitfall traps were modified to allow organisms to escape, while collecting valuable ecological data. Modified camera traps were capable of detecting the same species as traditional traps in a semi-arid environment, without posing the associated mortality risks. Pitfall-camera traps were used to sample the activity of the Side-blotched Lizard (Uta stansburiana) and the Southwestern Fence Lizard (Sceloporus cowlesi) in an urban wetland during four continuous years. Evaluations on activity pattern and the activity overlap between the two species revealed extensive overlap, with minor but significant seasonal shifts mediating coexistence. Traps were also effective at detecting other reptiles, invertebrates, …

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Exploring The Misalignment Between State And Federal Policies: Trials And Tribulations In A West Texas School District, James Dustin Anderson Dec 2023

Exploring The Misalignment Between State And Federal Policies: Trials And Tribulations In A West Texas School District, James Dustin Anderson

Open Access Theses & Dissertations

AbstractThis dissertation examines the complex interplay between state and federal educational policies and their real-world implications within the Texas public education system. Utilizing an autoethnographic approach, the study delves into the experiences of an educational leader during the so-called West Texas School District Cheating Scandal. This event was not an instance of academic dishonesty but rather a significant misalignment between state mandates and federal requirements, specifically surrounding standardized testing protocols. The narrative, constructed through detailed vignettes, brings to life the educator's struggle against the backdrop of this policy dissonance, offering a rich analysis of the situation's ethical, administrative, and systemic …

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Towards A Model Of The Mapping Between English And Spanish Prosody, Jonathan Avila Dec 2023

Towards A Model Of The Mapping Between English And Spanish Prosody, Jonathan Avila

Open Access Theses & Dissertations

Current speech-to-speech translation systems face challenges in effectively translating the nuances of prosody, which plays a pivotal role in conveying speaker intent and stance in dialog. This limitation restricts cross-lingual communication, especially in situations demanding deeper interpersonal understanding. To address this, this research delves into the relationships between prosody and its pragmatic functions, in English and Spanish. First, I discuss a data collection protocol in which bilingual speakers re-enact utterances from an earlier conversation in their other language, then describe an English-Spanish corpus, consisting of 3816 matched utterance pairs. Second, I describe a prosodic dissimilarity metric based on Euclidean distance …

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Upcyclying Of Polyethylene Terephtalate By Addition Of Thermoplastic Elastomer, Diego Francisco Bermudez Dec 2023

Upcyclying Of Polyethylene Terephtalate By Addition Of Thermoplastic Elastomer, Diego Francisco Bermudez

Open Access Theses & Dissertations

Continual overconsumption of single-use plastics has generated challenges of solid waste management across the United States. Common plastic waste management solutions, such as landfill, have caused the migration of contaminants into the environment consequently affecting not only the health of wildlife, but also that of human beings. Alternative strategies for the handling of single-use plastic such as polyethylene terephthalate (PET), used in the food packaging industry, can ultimately help mitigate the noxious consequences of single-use plastics affecting entire ecosystems. This study demonstrates a potential avenue of materials upcycling by studying the effects of coupling PET with the thermoplastic elastomer styrene-ethylene-butylene-styrene …

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Development Of Metaheuristic Algorithms For The Efficient Allocation Of Power Flow Control Devices, Eduardo Jose Castillo Fatule Dec 2023

Development Of Metaheuristic Algorithms For The Efficient Allocation Of Power Flow Control Devices, Eduardo Jose Castillo Fatule

Open Access Theses & Dissertations

No abstract provided.

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Deep-Learning Frameworks For The Classification And Segmentation Of Alzheimer's Disease Cell Types, Md Easin Hasan Dec 2023

Deep-Learning Frameworks For The Classification And Segmentation Of Alzheimer's Disease Cell Types, Md Easin Hasan

Open Access Theses & Dissertations

Neuroimaging experts in biotech industries can benefit from using cutting-edge artificial intelligence techniques for Alzheimerâ??s disease (AD) and dementia stage prediction, despite the fact that it may be difficult to anticipate the precise stage of AD. AD is one cause of dementia with very limited to no treatment available. Cell-type classification studies are essential for developing novel drugs for this lethal and common disease. Neuronal cell segmentation is the process of identifying and separating individual neurons in an image, typically in order to study their properties or analyze their organization in the nervous system. This is significant because neurological problems …

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A Noninvasive Urine-Based Method For Kidney Cancer Early Detection, Kiana Holbrook Dec 2023

A Noninvasive Urine-Based Method For Kidney Cancer Early Detection, Kiana Holbrook

Open Access Theses & Dissertations

Based on the traditional serological uses to obtain diagnoses of cancer and biopsy techniques, common cancer detection could be not only invasive but expensive and some tests are also unreliable. Currently, urine is one of the most frequently used and collected specimens in the clinical diagnoses. While the areas of urinalysis and metabolomic profiling has received interest in the top clinical research, there are limited components to the validity, specificity, as well as sensitivity of endogenous urine substrates to detect early stages of cancers. Although there is research showcasing that urine is impacted by age, cancer type, geographical location, and …

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The Physiological Effects Of Acute And Ramp Hypoxic Exposure During Simulated Flight Tasks, Jasmin Renee Jenkins Dec 2023

The Physiological Effects Of Acute And Ramp Hypoxic Exposure During Simulated Flight Tasks, Jasmin Renee Jenkins

Open Access Theses & Dissertations

The purpose of the present study was to examine the effects of hypoxia at simulated altitudes of FiO2 15.4% (8000’ equivalent), FiO2 13.2% (12,000’ equivalent), and a Ramp Hypoxic exposure on perceived workload, cardiovascular activity, electrodermal activity, oximetry, and flight simulator performance. A total of 17 participants (10 female & 7 males; mean ± SEM, age 24.82±1.6 yrs, BMI 25.87±1.0 who were apparently healthy, asymptomatic, and physically active performed 3 flight tasks using a video game head-mounted display (HMD) flight simulator while exposed to simulated altitudes of Normoxia, FiO2 15.4%, FiO2 13.2% and a Ramp Hypoxic Exposure (breathing at 8,000 …

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Southern Rio Grande Rift Kinematics And Geochronology, Big Bend Fold Geometry, And The Use Of Real Data In Geoscience Education: Contributions To The Understanding Of Big Bend Geology And To Public Geoscientific Literacy, Jessica Kelsch Dec 2023

Southern Rio Grande Rift Kinematics And Geochronology, Big Bend Fold Geometry, And The Use Of Real Data In Geoscience Education: Contributions To The Understanding Of Big Bend Geology And To Public Geoscientific Literacy, Jessica Kelsch

Open Access Theses & Dissertations

The Big Bend region of Trans-Pecos Texas preserves a rich record of Rio Grande rifting and Laramide-age contraction that provide intrigue to national and state park visitors and field trips for undergraduate geology students. Despite its well-exposed geologic record, the Big Bend region remains an underutilized natural laboratory for studying these two tectonic events. This dissertation combines structural studies of Rio Grande rift and Laramide structures with public outreach and geoscience education studies focused on the Big Bend region. In Chapter 2, existing extensional-kinematic studies from parts of this region are compiled with new fault kinematic and U-Pb geochronologic data …

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Leveraging Agile Software Methodologies Within Software Development To Introduce A Novel Educational Software Methodology, Montserrat Guadalupe Molina Dec 2023

Leveraging Agile Software Methodologies Within Software Development To Introduce A Novel Educational Software Methodology, Montserrat Guadalupe Molina

Open Access Theses & Dissertations

Agile Software Development has been growing increasingly popular in the software engineering industry as a way to produce working software in a quick and people-centered manner. Agile methodologies require practitioners to have strong technical and non-technical skills, such as teamwork, project management, and communication skills. Students graduating from the software engineering discipline have been found to be lacking in these areas, leading to many difficulties faced by recent graduates as they begin their professional careers. Given that Agile Software Development is the most popular software development lifecycle currently used by practitioners in industry, it is important to expose students to …

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Sterically Encumbering Ligands For The Synthesis And Stabilization Of Iron Nitride And Iron Oxo Compounds, Asiel Mena Dec 2023

Sterically Encumbering Ligands For The Synthesis And Stabilization Of Iron Nitride And Iron Oxo Compounds, Asiel Mena

Open Access Theses & Dissertations

The study of iron-nitrides has been found to be very attractive due to their potential role in processes like Haber-Bosch and nitrogen fixation by nitrogenase. The role of iron-nitrides in these processes is yet not well understood, and the fact that only handful of terminal iron-nitrides have been isolated or spectroscopically detected motivates us to study this type of systems, since much remains to be learned about the electronic and structural factors that affect the chemistry of the Feâ?¡N bond. Recently in our group, by using a super-bulky guanidinate ligand (LAr*), the obtention of an iron-nitride ([LAr*]FeN(py) (LAr* = (Ar*N)2C(NCtBu2), …

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Integrating Machine Learning Methods For Medical Diagnosis, Jazmin Quezada Dec 2023

Integrating Machine Learning Methods For Medical Diagnosis, Jazmin Quezada

Open Access Theses & Dissertations

Abstract:The rapid advancement of machine learning techniques has revolutionized the field of medical diagnosis by offering powerful tools to analyze complex data sets and make accurate predictions. In this proposed method, we present a novel approach that integrates machine learning and optimization models to enhance the accuracy of medical diagnoses. Our method focuses on fine-tuning and optimizing the parameters of machine learning algorithms commonly used in medical diagnosis, such as logistic regression, support vector machines, and neural networks. By employing optimization techniques, we systematically explore the parameter space of these algorithms to discover the most optimal configurations. Moreover, by representing …

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Using Shallow Electromagnetic And Magnetic Techniques To Map Soil Texture And Characterize Salinity And Water Dynamics Below Pecan Orchards, El Paso County, Texas, Kristina Sasser Dec 2023

Using Shallow Electromagnetic And Magnetic Techniques To Map Soil Texture And Characterize Salinity And Water Dynamics Below Pecan Orchards, El Paso County, Texas, Kristina Sasser

Open Access Theses & Dissertations

Non-invasive, near surface geophysical tools provide a time efficient and cost-effective approach to study the shallow subsurface. Electromagnetic induction (EMI) instruments are a category of these near surface methods that provide spatial and temporal information (2-D to 4-D) about shallow (<6 m) subsurface properties, from which soil salinity, clay content, and water content can be estimated. However, deconstructing soil apparent electrical conductivity (ECa) from EMI methods into its component parts remains a challenge. This research uses EMI and magnetic geophysical techniques to: (1) compare and contrast the distribution and behavior of ECa, both spatially and temporally, at two flood irrigated agricultural sites (pecan orchards) with different soil layers, properties, and controls on electrical conductivities that lie within the same floodplain in far west Texas; and (2) develop a one-dimensional inversion model using ECa and soil texture data at specified layers from established sites of known high and low ECa to determine soil layer resistivities at various dates during the irrigation season. Data are compared to soil sensor bulk EC and volumetric water content data at corresponding depths to validate results. Soils at both sites exhibit large ECa contributions from textural controls, and irrigation frequency. The combination of these two controls dictate where and how quickly secondary minerals precipitate, clog soil pores, reduce infiltration, and salinize the groundwater. Insight from this research aids in ongoing efforts to characterize vadose zone hydrology in dryland critical zones with high infiltration and serves as a guide for locations where future soil sampling will occur.

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Bitcoin's Technical Foundation And Its Potential For A Decentralized And Environmentally Friendly Future, Iqtiar Md Siddique Dec 2023

Bitcoin's Technical Foundation And Its Potential For A Decentralized And Environmentally Friendly Future, Iqtiar Md Siddique

Open Access Theses & Dissertations

This research examines a systematic analysis of Bitcoin, employing a Coefficient of Variation (CV) approach to gauge its degree of decentralization. Bitcoin, an innovative decentralized digital currency, has received much attention for its potential to revolutionize traditional financial systems. This study employs the Coefficient of Variation (CV) to acquire insights into the wealth distribution and concentration among Bitcoin users. This research demonstrates how decentralized the network of Bitcoin is. The methodology uses real data on Bitcoin addresses and their holdings to compute the Coefficient of Variation (CV). This approach provides valuable insights into the ongoing discourse surrounding Bitcoin's decentralization, offering …

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A Case Study On Promoting A Healthy School Culture To Combat Childhood Obesity And The Role Of The Principal, Nancy Torres Dec 2023

A Case Study On Promoting A Healthy School Culture To Combat Childhood Obesity And The Role Of The Principal, Nancy Torres

Open Access Theses & Dissertations

AbstractObesity is the leading cause of death worldwide. Childhood obesity has jumped to 22.4% in 2020 from 19.3% in 2019. One-third of children are overweight and obese, with an approximately 66% chance of becoming an obese adult. The costs of obesity are to overall health: financial, physical, social, and emotional. Obesity affects students at school, a point of service. Therefore, the purpose of this study was to examine what efforts has the principal undertaken to address childhood obesity in a Title I elementary school on the US-Mexico border and how these efforts helped to define and shape the schoolâ??s culture. …

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Structural Studies Of The Human Hsp60 And Bacteriophage Phiel Chaperonins, Daniel Han Von Salzen Dec 2023

Structural Studies Of The Human Hsp60 And Bacteriophage Phiel Chaperonins, Daniel Han Von Salzen

Open Access Theses & Dissertations

Chaperonins are large protein complexes responsible for the refolding of misfoldedsubstrate. Many mechanisms of the folding process have not been completely elucidated. Here we perform biochemical and structural analysis on two chaperonins, the human mitochondrial Hsp60 and the bacteriophage EL encoded PhiEL, to better understand key structural components and their purpose to the chaperonin function. Hsp60 plays an essential role in maintaining protein within the mitochondrial matrix. Despite its importance, the detailed mechanism of ATP hydrolysis and the role of the C-terminal tail remains unresolved. Here we show that the C-terminal tail not only acts as a sensor for the …

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Diverse Impacts Of Commercial Ev Charging Load Infrastructure On Electric Power Grid, Antonio Avila Dec 2023

Diverse Impacts Of Commercial Ev Charging Load Infrastructure On Electric Power Grid, Antonio Avila

Open Access Theses & Dissertations

With the rising prominence of electric vehicles (EVs) in the transportation sector, this thesis delves into the critical nexus between commercial EVs, charging infrastructure, and their consequential impacts on the power grid. As commercial EVs, particularly medium and heavy-duty variants, gain traction as viable alternatives in the commercial transportation landscape, understanding the intricacies of their charging requirements becomes paramount. This thesis critically examines the technological and logistical dimensions of the charging infrastructure for supporting commercial EVs, evaluating the consequential implications on the power grid and proposing strategies for mitigation through the utilization of Distributed Energy Resources (DERs). In tandem with …

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Alteration And Mineralization Of The Deep Extension Of The Giant Chuquicamata Porphyry Copper Deposit, Northern Chile, Claudio Andres Araya Torres Dec 2023

Alteration And Mineralization Of The Deep Extension Of The Giant Chuquicamata Porphyry Copper Deposit, Northern Chile, Claudio Andres Araya Torres

Open Access Theses & Dissertations

Porphyry copper deposits are the major source of copper and molybdenum in the world. The deposits consist of large volumes of rock altered by hydrothermal fluids released by shallow, intermediate composition magma chambers, with metallic mineralization present in veins, breccias, and disseminations; ore grades are typically 0.3-1.0 wt.% Cu. The subject of this study, the Chuquicamata porphyry copper deposit in northern Chile, is one of the most productive such deposits in the world, with over 45 million tons of Cu produced since large scale, open pit mining started early in the XXth century. Current production at Chuquicamata is from an …

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Study Of Human Circadian Protein (Hrory) And Lipid-Protein Interaction In Giant Virus (Pbcv-1), Laila Noor Dec 2023

Study Of Human Circadian Protein (Hrory) And Lipid-Protein Interaction In Giant Virus (Pbcv-1), Laila Noor

Open Access Theses & Dissertations

Project 1: Circadian rhythm is a 24-hour cycle that regulates physical and behavioral changes such as sleep-wake patterns in humans, tailoring the daily light and dark changes. Long-term disruption in circadian rhythms can cause sleep disorders such as sleep apnea, insomnia, et al. Limited research has been done on potential drugs to treat against circadian related sleep disorders. Inside the cell at molecular level, the circadian rhythm is regulated by interlocked time-delayed feedback loops, which involve positive and negative transcriptional regulators. Experimental results showed transcriptional factors Retinoic Acid Receptor-Related Orphan Receptors (RORs) improve the stability and functionality of the circadian …

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Viability Of Magnetic Nanoparticles For Magnetic Hyperthermia Cancer Therapy, Marcos Adrian Garcia Dec 2023

Viability Of Magnetic Nanoparticles For Magnetic Hyperthermia Cancer Therapy, Marcos Adrian Garcia

Open Access Theses & Dissertations

Over the last few decades magnetic nanoparticles have gained an extraordinary amount of attention in the science community. Their versatile use in many different research areas such as medicine, engineering and technology and many other areas has made them a popular subject. In this thesis, the synthesis of different systems of magnetic nanoparticles will be explored along with the potential use of the MNP's as viable candidates for Magnetic Hyperthermia Cancer Therapy. With values of over 200 emu/g for Iron-Silver magnetic nanoparticles with particle sizes ranging from 30-70nm and their heating properties under an AC magnetic field. As well of …

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Tracking Emissions In Power Systems, Kenji Santacruz Dec 2023

Tracking Emissions In Power Systems, Kenji Santacruz

Open Access Theses & Dissertations

Greenhouse gas emissions have been increasing in concentration in the atmosphere, which poses risks to the environment. Since 2011, the 𝐶𝐶𝐶𝐶2 emissions reached an average of 410 parts per million (ppm). The burning of fossil fuels for energy production was identified as the primary source of these emissions, making up 25% of global emissions by sector in 2010. To promote sustainable practices, there is an increasing need to accurately track greenhouse gas emissions in power systems. To accomplish this, an emission tracking method that can provide emission information for each load point in real-time is needed. In addition, certain indices …

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Towards A Spaceworthy Cots Graphics Processing Unit: Hardware Performance Counter Based Symptomatic Fault Detection, Antonio E. Teijeiro Dec 2023

Towards A Spaceworthy Cots Graphics Processing Unit: Hardware Performance Counter Based Symptomatic Fault Detection, Antonio E. Teijeiro

Open Access Theses & Dissertations

Ionizing radiation remains an obstacle to bringing graphics processing units (GPU) to space. Since radiation-hardened GPU chips are technically infeasible at the moment, an emphasis has been placed on the adaptation of commercial-off-the-shelf (COTS) GPUs to the space domain. At present, GPU error detection methods require redundant computation. This thesis work explores the utilization of hardware performance counters, special registers useful for monitoring internal GPU hardware events, for symptom-based, lightweight error detection. Hardware performance counters are successfully utilized for the detection of anomalous single event upsets in the L0 instruction cache, the load store unit, the arithmetic and logic unit, …

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Cloud Computing In The World Of Generative Ai, Yassine Chahid, Patrick Slattery Dec 2023

Cloud Computing In The World Of Generative Ai, Yassine Chahid, Patrick Slattery

Publications and Research

The purpose of this research is to evaluate the progress of cloud computation and generative artificial intelligence, and how the improvements in these respective technologies could be combined for future uses. Cloud computation and generative AI have rapidly developed in their capabilities. By analyzing the ways in which cloud computing and generative AI have been implemented thus far, a better understanding can be established regarding how they may influence current tech solutions within the information technology sector and beyond. The first portion of research consisted of researching the current capabilities of the two technologies respectively. By reviewing relevant publications and …

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