Digital Commons Network^™

Selecting Patient-Reported Outcome Measures For A Patient-Facing Technology, Priyank Raj, Youmin Cho, Yun Jiang, Yang Gong

Faculty, Staff and Student Publications

OBJECTIVE: This article provides insight into our process and considerations for selecting patient-reported outcome measures (PROMs) designed for self-reporting symptoms and quality-of-life among breast cancer (BCA) patients undergoing oral anticancer agent treatment via a patient-facing technology (PFT) platform.

METHODS: Following established guidelines, we conducted a thorough assessment of a specific set of PROMs, comparing their content to identify the most suitable options for studying BCA patients.

RESULTS: We recommend utilizing the combination of EORTC QLQ-C30 + EORTC QLQ-BR45 as the preferred instrument, especially when developing a dedicated "breast cancer-only" application.

DISCUSSION: When developing and maintaining a dashboard for a PFT …

Discovery Of Novel 2-Aminopyridine Derivatives As Ros1 And Alk Dual Inhibitors To Combat Drug-Resistant Mutants Including Ros1g2032r And Alkg1202r, Siming Liu, Chuan Huang, Chunhui Huang, Yaqi Huang, Yonghuan Yu, Guowu Wu, Fengqiu Guo, Ying Jiang, Shanhe Wan, Zhengguang Zhu, Yuanxin Tian, Jianghua Zhu, Jiajie Zhang

Faculty, Staff and Student Publications

Clinical treatment by FDA-approved ROS1/ALK inhibitor Crizotinib significantly improved the therapeutic outcomes. However, the emergence of drug resistance, especially driven by acquired mutations, have become an inevitable problem and worsened the clinical effects of Crizotinib. To combat drug resistance, some novel 2-aminopyridine derivatives were designed rationally based on molecular simulation, then synthesised and subjected to biological test. The preferred spiro derivative C01 exhibited remarkable activity against CD74-ROS1G2032R cell with an IC50 value of 42.3 nM, which was about 30-fold more potent than Crizotinib. Moreover, C01 also potently inhibited enzymatic activity against clinically Crizotinib-resistant ALKG1202R, harbouring a 10-fold potency superior to …

Godel, Escherian Staircase And Possibility Of Quantum Wormhole With Liquid Crystalline Phase Of Iced-Water - Part I: Theoretical Underpinning, Victor Christianto, T. Daniel Chandra, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

As a senior physicist colleague and our friend, Robert N. Boyd, wrote in a journal (JCFA, Vol. 1,. 2, 2022), Our universe is but one page in a large book [4]. For example, things and Beings can travel between Universes, intentionally or unintentionally. In this short remark, we revisit and offer short remark to Neil’s ideas and trying to connect them with geometrization of musical chords as presented by D. Tymoczko and others, then to Escher staircase and then to Jacob’s ladder which seems to point to possibility to interpret Jacob’s vision as described in the ancient book of Genesis …

Godel, Escherian Staircase And Possibility Of Quantum Wormhole With Liquid Crystalline Phase Of Iced-Water - Part Ii: Experiment Description, Victor Christianto, T. Daniel Chandra, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

The present article was partly inspired by G. Pollack’s book, and also Dadoloff, Saxena & Jensen (2010). As a senior physicist colleague and our friend, Robert N. Boyd, wrote in a journal (JCFA, Vol. 1, No. 2, 2022), for example, things and Beings can travel between Universes, intentionally or unintentionally [4]. In this short remark, we revisit and offer short remark to Neil Boyd’s ideas and trying to connect them with geometry of musical chords as presented by D. Tymoczko and others, then to Escherian staircase and then to Jacob’s ladder which seems to pointto possibility to interpret Jacob’s vision …

Assessing The Morphological And Physiological Traits Of Smooth Brome Pastures Under Long Term Grazing And Nutrient Enrichment In Eastern Nebraska, Hassan Shehab

School of Natural Resources: Dissertations, Theses, and Student Research

Climate change together with the increase in demands for food, feed, fuel, and fiber are becoming a threat to sustainability and resilience of agriculture and pasture lands. Bromus inermis (smooth bromegrass) dominates pastures for cattle grazing in Eastern Nebraska, US, where it is planted in monocultures, and is considered high quality forage because of its palatability and high nutritional value for cattle, especially under intensive management practices. Sustainable management of these pastures is key to long-term resilience. This study aims to assess the performance of smooth bromegrass pastures to the combined effects of long-term management practices (since 2005) of fertilization …

Ecological Impacts Of Restoring Fire-Grazing Interaction In Sandhills Prairie Through Patch-Burn Grazing, Nolan P. Sipe

School of Natural Resources: Dissertations, Theses, and Student Research

A Collaborative Adaptive Management (CAM) Project was started at the University of Nebraska in 2020 to address some of the key uncertainties related to the management of grasslands in the Nebraska Sandhills through stakeholder driven experiments and the adaptive management cycle. Patch-burn grazing was selected by CAM as a management tool to generate heterogeneity across the landscape and promote biodiversity while balancing economic and ecological trade-offs. The patch-burn grazing system was implemented with controlled burns in May of 2022 and March of 2023. Other parties in CAM will be examining the impact that patch-burn grazing has on forage and livestock …

Population Demography Of A Glacial-Relict Stream Fish Mediated Via Anthropogenic Alteration, Joseph M. Spooner

School of Natural Resources: Dissertations, Theses, and Student Research

Northern Pearl Dace Margariscus nachtriebi are a small-bodied glacial-relict fish species of greatest conservation need (SGCN) found throughout Canada and the northern United Sates. Their distribution within the Nebraska Sandhills Ecoregion is isolated from the northern core distribution of the species following the last glaciation period approximately 18,000 years ago. Headwater streams within the Nebraska Sandhills Ecoregion are predominately groundwater fed and provide the cool water temperatures needed to support Northern Pearl Dace and other glacial-relict SGCN. Headwater streams within the Nebraska Sandhills Ecoregion have been geomorphically altered through anthropogenic processes such as channelization whereby habitat homogenization has occurred. Evidence …

Human Dimensions Of Woody Encroachment Management In Nebraska, Emily Rowen

School of Natural Resources: Dissertations, Theses, and Student Research

Woody plant encroachment (WPE) is a social-ecological problem that will challenge conservation professionals and agricultural producers to adapt their management strategies. This research first examined WPE from the perspective of individual conservation professionals through an online survey. Conservation professionals’ attitudes about adaptation to vegetation transitions, such as WPE, were of interest because these attitudes are one measure of how prepared this group is to respond to WPE. Hypothesized predictors of adaptation attitude were tested through linear regression modeling. These predictors included ecological change, observation of WPE, or risk perception. It was found that risk perception was the strongest predictor of …

Habitat Heterogeneity In Nebraska Streams And Distribution Prediction For Tier-1 Cyprinids Using Multi-Scale Modeling Of Fluvial And Landscape Features, Connor P. Hart

School of Natural Resources: Dissertations, Theses, and Student Research

Multiscale environmental processes determine in-stream habitat conditions which drive species distributions. Habitat constitutes the physical template upon which ecological processes occur and species conduct life stage activities. Habitat heterogeneity promotes biodiversity of aquatic systems. Stream classification informs freshwater conservation by providing a useful framework to account for habitat heterogeneity, often based on landscape regions of similar environmental processes. A greater understanding of landscape-based classification frameworks as means to classify stream systems may improve understanding of drivers of biodiversity. Using Nebraska as a case study, on a statewide scale, objectives were 1) to characterize habitat availability for several at-risk fish species, …

The Influence Of Invasive Species On Fishers’ Satisfactions, Caroline M. Laplante

School of Natural Resources: Dissertations, Theses, and Student Research

Invasives species are prevalent and widespread in North America. Outdoor recreational activities, such as fishing, introduce a point in which humans may interact with invasive species and have to adapt their own behaviors. Bigheaded carp in the Missouri River below Gavin’s Point Dam are a group of invasive fish species that were thought to be negatively relating to recreational fishers’ satisfactions. Using a content analysis and an importance-grid, we conclude that invasive species do not strongly relate to recreational paddlefish fishers’ satisfactions. Paddlefish fishers represent a small sub-set of recreational fishers in Nebraska and South Dakota. The content analysis revealed …

Understanding Avidities Of Recreational Activities For People Possessing Fishing Licenses And Residing In Urban Environments, Kyle F. Hansen

School of Natural Resources: Dissertations, Theses, and Student Research

Recreational fishing is one of the world's most popular pastimes, wherein participation is associated with sociodemographic factors. Even so, fishing license sales are declining in the USA in conjunction with a reduction in rural populations as people move to urban areas. Thus, urban areas are constantly growing in population size, population diversity, and geographic size suggesting a need to understand fishing participation in these growing areas. Natural resource managers often use participation to understand recreationists, yet avidity could provide a new way to understand recreationists. The goal of our study is to understand what sociodemographic factors influence the fishing avidity …

Unexpectedness Stratified By Codimension, Frank Zimmitti

Department of Mathematics: Dissertations, Theses, and Student Research

A recent series of papers, starting with the paper of Cook, Harbourne, Migliore, and Nagel on the projective plane in 2018, studies a notion of unexpectedness for finite sets Z of points in N-dimensional projective space. Say the complete linear system L of forms of degree d vanishing on Z has dimension t yet for any general point P the linear system of forms vanishing on Z with multiplicity m at P is nonempty. If the dimension of L is more than the expected dimension of t−r, where r is N+m−1 choose …

On Dyadic Parity Check Codes And Their Generalizations, Meraiah Martinez

Department of Mathematics: Dissertations, Theses, and Student Research

In order to communicate information over a noisy channel, error-correcting codes can be used to ensure that small errors don’t prevent the transmission of a message. One family of codes that has been found to have good properties is low-density parity check (LDPC) codes. These are represented by sparse bipartite graphs and have low complexity graph-based decoding algorithms. Various graphical properties, such as the girth and stopping sets, influence when these algorithms might fail. Additionally, codes based on algebraically structured parity check matrices are desirable in applications due to their compact representations, practical implementation advantages, and tractable decoder performance analysis. …

In Situ Water Sensing Systems: Research On Advancements In Environmental Monitoring, Abigail Seibel

Honors Program: Senior Projects (Public)

In this work, two sensing systems were researched in order to improve in situ environmental monitoring. The first is a pH and Total Alkalinity sensor used to determine these characteristics of sea water. I explored the facets of this sensor over a 7-week internship with Dr. Ellen Briggs in her lab in summer of 2023. The second is a more holistic sensing system that reads temperature, turbidity, and pressure used for studying environmental characteristics of Alaskan bever ponds. Both systems were developed in close collaboration with scientists who are collecting data to better understand the impacts of climate change. Better …

Game-Theoretic Approaches To Optimal Resource Allocation And Defense Strategies In Herbaceous Plants, Molly R. Creagar

Department of Mathematics: Dissertations, Theses, and Student Research

Empirical evidence suggests that the attractiveness of a plant to herbivores can be affected by the investment in defense by neighboring plants, as well as investment in defense by the focal plant. Thus, allocation to defense may not only be influenced by the frequency and intensity of herbivory but also by defense strategies employed by other plants in the environment. We incorporate a neighborhood defense effect by applying spatial evolutionary game theory to optimal resource allocation in plants where cooperators are plants investing in defense and defectors are plants that do not. We use a stochastic dynamic programming model, along …

From Becoming To Being: How Stem Teachers Develop Leadership Identities, Kelsey Quaisley, Wendy M. Smith, Brett A. Criswell, Rachel Funk, Anna Hutchinson

Secondary Education Faculty Publications

The development of STEM teacher leadership identity empowers K-12 teachers to make changes to improve teaching and learning. Identity development might not be productively supported in all school settings, however. Hence, external professional development programs should offer opportunities to supplement this identity development. We construct and propose a Can't-to-Becoming-to-Being model to describe STEM teacher leadership identity development as a progression of stages from weak to strong identity. Using interview data over two points in time with 127 STEM teacher leaders, we illustrate four stages of development: Can't, Can, Should, and Being. We also elucidate the conditions that teachers identify as …

The Impact Of Neighborhood Socioeconomic Disadvantage On Operative Outcomes After Single-Level Lumbar Fusion, Grace Y. Ng, Ritesh Karsalia, Ryan S. Gallagher, Austin J. Borja, Jianbo Na, Scott Mcclintock, Neil R. Malhotra

Mathematics Faculty Publications

INTRODUCTION: The relationship between socioeconomic status and neurosurgical outcomes has been investigated with respect to insurance status or median household income, but few studies have considered more comprehensive measures of socioeconomic status. This study examines the relationship between Area Deprivation Index (ADI), a comprehensive measure of neighborhood socioeconomic disadvantage, and short-term postoperative outcomes after lumbar fusion surgery. METHODS: 1861 adult patients undergoing single-level, posterior-only lumbar fusion at a single, multihospital academic medical center were retrospectively enrolled. An ADI matching protocol was used to identify each patient's 9-digit zip code and the zip code-associated ADI data. Primary outcomes included 30- and …

Exploring The Mechanistic Effects Of Surface Characteristics On Uv254 And Bl405 Disinfection Efficacy, Castine Annastasia Bernardy

Doctoral Dissertations

The COVID-19 pandemic highlighted the need for more robust surface disinfection technologies. Photoinactivation efficacy for microbial pathogens and many surrogates has been well studied for water disinfection. However, there is a limited body of knowledge from research on surface disinfection applications of these technologies. The onset of the global pandemic resulted in a dramatic increase in surface disinfection devices being marketed to consumers, yet regulations for such devices have not been developed. This doctoral research studies the inactivation efficacy of two wavelengths, UV254 and BL405. The objective of this doctoral dissertation was to expand the body of knowledge required to …

Aspects Of Localizing Quantum Information In Diffeomorphism-Invariant Theories, Adam Dukehart

Doctoral Dissertations

Quantum Field Theory (QFT) is often formulated using local operators, i.e., operators defined at points on a fixed background spacetime. However, General Relativity (GR) requires that observables be fully diffeomorphism invariant. This includes invariance not only under passive diffeomorphisms, which change the coordinate system but also active diffeomorphisms, which imply background independence and a dynamical metric. Localizing such systems and observables in quantum gravity has been a long-standing problem. This dissertation makes progress on two facets of this problem. Part I shows that a typical quantum information paradox using local operators cannot be embedded in a self-consistent, low-energy prescription which …

Learning Trajectories From Human Demonstration Via Time Invariant Dynamical Systems, Paul Gesel

Doctoral Dissertations

Learning from Demonstration (LfD) is a powerful approach that enables users to program robots by simply demonstrating how to perform tasks. Rather than just mimicking the task, the robot should capture key characteristics of the task to adapt and generalize in various situations. Given that there is no explicit objective for each demonstrated task, optimal control methods cannot be directly applied. Two primary paradigms have emerged to overcome the limitation: 1) inverse learning and 2) imitation learning. In this dissertation, I formulate several time-invariant and stable dynamic system-based LfD models that leverage both inverse learning and imitation learning in the …

Potential Vorticity Dynamics Driving Variability In Mean Tidal Currents Flowing Through Bounded Estuarine Channels, Katherine Anne Kirk

Doctoral Dissertations

Tidally induced pressure gradients in sea level drive mean estuarine tidal currents that can have horizontal spatial variability across a bounded channel or inlet. Strong cross-channel gradients in along-channel mean velocity set up extremums in the background potential vorticity that can support instabilities of tidal currents flowing through narrow, bounded estuarine channels and tidal inlets. In addition, conservation of potential vorticity including frictional terms, results in intensification of along-channel tidal currents over shallow lateral shelves. In the first part of this dissertation (Chapter 2), the dispersion equation of barotropic instabilities of tidal currents is analytically solved for simple bathymetry defined …

Investigation Of Robust And Adaptive Control Methods For Systems With Uncertain Equilibrium States, Muhammad Hamad Zaheer

Doctoral Dissertations

Equilibrium states represent the natural resting point of dynamic systems in their state-space and provide vital information for the design of stabilizing feedback controllers for these systems. Stabilizing a system at an equilibrium state is desirable as it requires a zero steady-state control signal, resulting in lower energy consumption by the actuator. Mathematical models of real systems usually contain uncertainties that make it difficult to determine the exact values of these equilibrium states. Therefore, control methods requiring precise knowledge of the equilibrium state are ineffective in controlling systems when uncertainties make determining the exact value of the equilibrium state challenging …

Thoughtful Learning: An Investigation Of The Relationships Between College Students’ Achievement Appraisals And Thinking Patterns During Lecture, Shelby Lynn Smith

Doctoral Dissertations

The current set of studies examined whether two common appraisals that students make during learning (whether they have control over their learning and whether they place value into learning the material) give rise to common types of thoughts students also experience (mind wandering, personal connections, and freely-moving thought). Study One naturistically examined students’ appraisals and thoughts while learning in a real classroom. Study Two attempted to experimentally manipulate students’ appraisals and thus their thoughts in an online learning environment. Overall, results suggest that appraisals do seem to influence the thoughts students report experiencing, although results differ between online and classroom …

Engineering Studies Of An Experimental Open Ocean Seaweed Farm Design, Zachary Moscicki

Doctoral Dissertations

An experimental seaweed cultivation system was designed for offshore and exposed locations. Novel features were incorporated to address major barriers to the expansion of seaweed, including limited nearshore and sheltered marine locations and risk of marine animal entanglement. A novel modular mooring geometry was developed to improve stability, reliability, and spatial efficiency to achieve an economical and robust structure viable in high wave energy environments. Stiff composite (e.g. fiberglass) rods were used to replace components typically made of rope, including mooring lines and seaweed growth substrate (cultivation lines), as a means to mitigate risk of marine animal entanglement.

This dissertation …

Discourses Across Periods Of Time, Amanda Raquel Moreno

Theses

This literature review explores the revolutionary effect of generative artificial intelligence (AI) and virtual reality (VR) on digital art history, specifically concentrating on their capacity to enable dialogical exchanges with historical figures and deepen the understanding of artworks. This study considers the current state of research, detecting key methodologies, areas of improvement, and possible challenges and ethical concerns. The example historical figure used in this analysis is the iconic Mexican artist Frida Kahlo. Kahlo’s refusal to correspond to a specific artistic style makes her an ideal subject for generative AI and VR-based investigation, offering fresh insights into her work. The …

Post-War Restitution In The Republic Of Croatia: Awareness Of The Komza And Reconciliation Of Moveable Property Through Public Sculpture, Anita Govic

Theses

This project is a public sculpture prototype focused on the need for post-war art restitution in the Republic of Croatia: it will have an impact by enhancing public knowledge of the KOMZA list, which offers legal proof for families to retrieve heirlooms taken during WWII and the wars of secession from Yugoslavia.

The sculpture design includes three pillars, two etched with the 1529 names from the KOMZA list and a third that will be progressively built, brick-by-brick, as artworks are restituted. The nature of viewers’ interaction includes access to QR codes that offer links to the KOMZA list, information about …

Sensitive Capacitance Measurements Of The Quantum Hall Effect In Graphene, Vergil Schreiber, Justin Alvarez, Joshua Island

Undergraduate Research Symposium Podium Presentations

Research on how electrons respond to confinement holds potential for breakthroughs in quantum computing and more energy efficient electronics. In intense magnetic fields and near-zero temperatures, electrons in confined to 2D display unique quantum behaviors. These conditions quantize electron motion into circular orbits, resulting in discrete Landau energy levels.

An Exploration Of Conventional Beamforming Applied To A Phase Measuring Sonar, Joao Celso Silva De Deus

Master's Theses and Capstones

Brazilian rivers are a particularly challenging navigation environment because of frequentchanges in bathymetry due to sediment transport. To accelerate the production of hydrographic information for these regions, the Brazilian Hydrographic Office has been investigating efficient ways of riverine surveying. In this context, Phase Measuring Bathymetric Sonars (PMBS) are being considered because of their potential to provide wider swaths than traditional Multibeam Echo Sounders (MBES) in shallow waters. Although these systems historically had severe limitations in sounding quality and nadir density, new models with multiple stave pairs are being built to overcome these issues, including the EdgeTech 6205, which claims to …

Usage Statistics: Project Counter R5 Tr_B1 Report Fy2023 - Book Requests (Excluding Oa_Gold) By Platform, Andrée J. Rathemacher

Technical Services Reports and Statistics

Project COUNTER R5 Report TR_B1 for the University of Rhode Island for the period from July 1, 2022 - June 30, 2023. The TR_B1 report is defined as "Book Requests (Excluding OA_Gold)." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.

File for download is Excel spreadsheet generated by Alma Analytics.

Results:

Total Item Requests - 118,197

Unique Title Requests - 46,803

Letter From The Vice President Of Research And Innovation, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.