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Codon-Optimized Tdp-43 Mediates Neurodegeneration In A Drosophila Model Of Als/Ftld, Tanzeen Yusuff, Ya-Chu Chang, Tzu-Kang Sang, George R Jackson, Shreyasi Chatterjee

Faculty, Staff and Students Publications

Transactive response DNA binding protein-43 (TDP-43) is known to mediate neurodegeneration associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The exact mechanism by which TDP-43 exerts toxicity in the brains, spinal cord, and lower motor neurons of affected patients remains unclear. In a novel Drosophila melanogaster model, we report gain-of-function phenotypes due to misexpression of insect codon-optimized version of human wild-type TDP-43 (CO-TDP-43) using both the binary GAL4/UAS system and direct promoter fusion constructs. The CO-TDP-43 model showed robust tissue specific phenotypes in the adult eye, wing, and bristles in the notum. Compared to non-codon optimized …

Establishing An Online Resource To Facilitate Global Collaboration And Inclusion Of Underrepresented Populations: Experience From The Mjff Global Genetic Parkinson’S Disease Project, Eva-Juliane Vollstedt, Harutyun Madoev, Anna Aasly, Azlina Ahmad-Annuar, Bashayer Al-Mubarak, Roy N Alcalay, Victoria Alvarez, Ignacio Amorin, Grazia Annesi, David Arkadir, Soraya Bardien, Roger A Barker, Melinda Barkhuizen, A Nazli Basak, Vincenzo Bonifati, Agnita Boon, Laura Brighina, Kathrin Brockmann, Andrea Carmine Belin, Jonathan Carr, Jordi Clarimon, Mario Cornejo-Olivas, Leonor Correia Guedes, Jean-Christophe Corvol, David Crosiers, Joana Damásio, Parimal Das, Patricia De Carvalho Aguiar, Anna De Rosa, Jolanta Dorszewska, Sibel Ertan, Rosangela Ferese, Joaquim Ferreira, Emilia Gatto, Gençer Genç, Nir Giladi, Pilar Gómez-Garre, Hasmet Hanagasi, Nobutaka Hattori, Faycal Hentati, Dorota Hoffman-Zacharska, Sergey N Illarioshkin, Joseph Jankovic, Silvia Jesús, Valtteri Kaasinen, Anneke Kievit, Peter Klivenyi, Vladimir Kostic, Dariusz Koziorowski, Andrea A Kühn, Anthony E Lang, Shen-Yang Lim, Chin-Hsien Lin, Katja Lohmann, Vladana Markovic, Mika Henrik Martikainen, George Mellick, Marcelo Merello, Lukasz Milanowski, Pablo Mir, Özgür Öztop-Çakmak, Márcia Mattos Gonçalves Pimentel, Teeratorn Pulkes, Andreas Puschmann, Ekaterina Rogaeva, Esther M Sammler, Maria Skaalum Petersen, Matej Skorvanek, Mariana Spitz, Oksana Suchowersky, Ai Huey Tan, Pichet Termsarasab, Avner Thaler, Vitor Tumas, Enza Maria Valente, Bart Van De Warrenburg, Caroline H Williams-Gray, Ruey-Mei Wu, Baorong Zhang, Alexander Zimprich, Justin Solle, Shalini Padmanabhan, Christine Klein

Faculty, Staff and Students Publications

Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder, currently affecting ~7 million people worldwide. PD is clinically and genetically heterogeneous, with at least 10% of all cases explained by a monogenic cause or strong genetic risk factor. However, the vast majority of our present data on monogenic PD is based on the investigation of patients of European White ancestry, leaving a large knowledge gap on monogenic PD in underrepresented populations. Gene-targeted therapies are being developed at a fast pace and have started entering clinical trials. In light of these developments, building a global network of centers working on monogenic PD, …

Open-Source, Highly Efficient, Post-Acquisition Synchronization For 4d Dual-Contrast Imaging Of The Mouse Embryonic Heart Over Development With Optical Coherence Tomography, Andre C Faubert, Irina V Larina, Shang Wang

Faculty, Staff and Students Publications

Dynamic imaging of the beating embryonic heart in 3D is critical for understanding cardiac development and defects. Optical coherence tomography (OCT) plays an important role in embryonic heart imaging with its unique imaging scale and label-free contrasts. In particular, 4D (3D + time) OCT imaging enabled biomechanical analysis of the developing heart in various animal models. While ultrafast OCT systems allow for direct volumetric imaging of the beating heart, the imaging speed remains limited, leading to an image quality inferior to that produced by post-acquisition synchronization. As OCT systems become increasingly available to a wide range of biomedical researchers, a …

Exploring Spectral Bias In Time Series Long Sequence Forecasting, Kofi Nketia Ackaah-Gyasi, Sergio Valdez, Yifeng Gao, Li Zhang

Computer Science Faculty Publications

Transformers have achieved great success in the task of time series long sequence forecasting (TLSF) in recent years. However, existing research has pointed out that over-parameterized deep learning models are in favor of low frequency and could be difficult to capture high-frequency information for regression fitting task, named spectral bias. Yet the effect of such bias on TLSF problem, an auto-regressive problem with a long forecasting length, has not been explored. In this work, we take the first step to investigate the spectral bias issues in TLSF task for state-of-the-art models. Specifically, we carefully examine three different existing time series …

Sphingolipids In Neurodegenerative Diseases, Xueyang Pan, Debdeep Dutta, Shenzhao Lu, Hugo J Bellen

Faculty, Staff and Students Publications

Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is affected in a surprisingly broad set of NDDs. These include some lysosomal storage diseases (LSDs), hereditary sensory and autonomous neuropathy (HSAN), hereditary spastic paraplegia (HSP), infantile neuroaxonal dystrophy (INAD), Friedreich’s ataxia (FRDA), as well as some forms of amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). Many of these diseases have been modeled in Drosophila melanogaster and are associated with elevated levels of ceramides. Similar changes have also been reported in vertebrate cells and mouse models. Here, we …

Chromosomal Microarray Analysis Supplements Exome Sequencing To Diagnose Children With Suspected Inborn Errors Of Immunity, Breanna J Beers, Morgan N Similuk, Rajarshi Ghosh, Bryce A Seifert, Leila Jamal, Michael Kamen, Michael R Setzer, Colleen Jodarski, Rylee Duncan, Devin Hunt, Madison Mixer, Wenjia Cao, Weimin Bi, Daniel Veltri, Eric Karlins, Lingwen Zhang, Zhiwen Li, Andrew J Oler, Kathleen Jevtich, Yunting Yu, Haley Hullfish, Bibiana Bielekova, Pamela Frischmeyer-Guerrerio, An Dang Do, Laryssa A Huryn, Kenneth N Olivier, Helen C Su, Jonathan J Lyons, Christa S Zerbe, V Koneti Rao, Michael D Keller, Alexandra F Freeman, Steven M Holland, Luis M Franco, Magdalena A Walkiewicz, Jia Yan

Faculty, Staff and Students Publications

PURPOSE: Though copy number variants (CNVs) have been suggested to play a significant role in inborn errors of immunity (IEI), the precise nature of this role remains largely unexplored. We sought to determine the diagnostic contribution of CNVs using genome-wide chromosomal microarray analysis (CMA) in children with IEI.

METHODS: We performed exome sequencing (ES) and CMA for 332 unrelated pediatric probands referred for evaluation of IEI. The analysis included primary, secondary, and incidental findings.

RESULTS: Of the 332 probands, 134 (40.4%) received molecular diagnoses. Of these, 116/134 (86.6%) were diagnosed by ES alone. An additional 15/134 (11.2%) were diagnosed by …

Understanding Advanced Practice Providers' Personal Factors That Influence Evaluating And Referring For Sleep Disorders In Pediatric And Adolescent Young Adult Cancer Survivors, Lindsay R. Melson

Dissertations

Pediatric and adolescent young adult (AYA) cancer survivors disproportionately experience sleep disorders compared to healthy peers. This dissertation examines the facilitators and barriers that influence advanced practice providers' (APPs) ability to evaluate and refer pediatric/AYA hematology oncology cancer survivors to sleep specialists. The first manuscript provides an integrative review of APPs' behaviors in screening for sleep disorders in pediatric/AYA cancer survivors using the Social Cognitive Theory as a guide. The second manuscript defines the concept of sleep disorders in pediatric cancer survivors using the Walker and Avant method. The third manuscript provides a qualitative analysis from interviews with hematology/oncology (heme/onc) …

The Influence Of Irrigation On Great Plains Diurnal Circulations And Boundary Layer Convective Rolls, Christopher E. Phillips

Dissertations

Agriculture is the most substantial change to the natural land surface made by humans, and irrigation plays a crucial role. Irrigation is utilized for 20% of croplands, and those regions produce 40% of the global food supply. The Great Plains Irrigation Experiment (GRAINEX) deployed to southeast Nebraska during the summer of 2018 to investigate the effects of irrigation on the atmosphere. This dissertation utilizes those observations in conjunction with numerical modeling to determine how irrigation modifies the Great Plains slope wind. Analysis of rawinsondes indicate that irrigation present in upslope regions of the domain weakens the slope wind circulation and …

Microphysical Examination Of Electrified Snowfall Events Using Goes Abi/Glm And Nu-Wrf, Sebastian S. Harkema

Dissertations

Much of the research using lightning, satellite, and numerical weather prediction model dataset involves the observation and prediction of warm season convection, whereas studies with regards to winter weather and heavy snowfall are sparse and nearly non-existent for electrified snowfall events. Single channel and multispectral composite satellite imagery were analyzed prior to lightning initiation in snowfall (i.e., thundersnow). Objectively tracked cloud features exhibited similar cloud-top brightness temperature and reflectance value changes – prior to thundersnow initiation – compared to cloud features associated with summertime lightning. Multispectral composite imagery – particularly the day cloud phase distinction – demonstrated consistent color changes …

Community-Based Early Dementia Advance Care Planning In The United States, Christine Noelle Flaherty

Dissertations

Dementia Advance Care Planning (ACP) promotes quality of life through discussions and decisions about goals of care and end-of-life wishes. However, ACP is rarely introduced in the community setting, and ACP is commonly deferred until advanced dementia when the patient can no longer communicate. The purpose of this three-manuscript dissertation was to advance the understanding of community-based early dementia ACP through an examination of the literature (manuscript one), the development of the dementia public health exposome conceptual framework (manuscript two), and the exploration of perceptions of ACP amongst dementia clinicians, dementia caregivers, and individuals with preclinical dementia in a dementia …

Improving Undergraduate Student Engagement In Stem Through Bioinformatics Research, Michele C. Morris

Dissertations

A novel intervention to introduce undergraduate students to bioinformatics, provide authentic research opportunities, and support student retention in science majors and careers is presented in the Characterizing Our DNA Exceptions (CODE) project. The need to increase the number of qualified STEM graduates, particularly in the fields of bioinformatics and computational research, was the impetus for this project that leads students down the path of scientific discovery as they characterize genomic variants of uncertain significance (VUS). This study sought to examine if student participation in a CODE research project would increase their bioinformatics awareness, interest, comfort, and knowledge, as well as …

Summary Of Tha 2022, Staff -

Halal Insight

No abstract provided.

From Market Making To Matchmaking: Does Bank Regulation Harm Market Liquidity?, Gideon Saar, Jian Sun, Ron Yang, Haoxiang Zhu

Research Collection Lee Kong Chian School Of Business

Post-crisis bank regulations raised market-making costs for bank-affiliated dealers. We show that this can, somewhat surprisingly, improve overall investor welfare and reduce average transaction costs despite the increased cost of immediacy. Bank dealers in OTC markets optimize between two parallel trading mechanisms: market making and matchmaking. Bank regulations that increase market-making costs change the market structure by intensifying competitive pressure from non-bank dealers and incentivizing bank dealers to shift their business toward matchmaking. Thus, post-crisis bank regulations have the (unintended) benefit of replacing costly bank balance sheets with a more efficient form of financial intermediation.

Leadership, Teaching And Learning In Times Of Crisis In Southern Tanzania, Nipael Mrutu, Peter Kajoro, Hamis Pintson Nkota

Institute for Educational Development, East Africa

The outbreak of the COVID-19 pandemic has had a significant impact on education provision worldwide. School leaders, teachers and parents found themselves in uncharted circumstances, which hugely impacted their roles in promoting children’s learning. The purpose of this study was to investigate the roles played by leaders, teachers, and parents during the COVID-19 crisis. This paper discusses teaching and learning in this time of crisis. The study sampled 10 head teachers, 60 schoolteachers and 57 parents representing 10 primary schools in five districts in the Lindi region of Tanzania. A postmodernism lens was applied to respond to questions about the …

Healthcare Workers' Well-Being: A Systematic Review Of Positive Psychology Interventions, Alexandra P Townsley, Jenny Li-Wang, Rajani Katta

Faculty, Staff and Students Publications

Given persistent occupational stressors and multiple challenges in the delivery of healthcare, there is an increased focus on the well-being of healthcare workers. Responding to these challenges will require a multipronged approach, focusing on system level, organization, and individual actions. Positive psychology interventions (PPIs) represent a promising area for individual action. This systematic review indicates that PPI, delivered via many methods, holds promise for improving the well-being of healthcare workers, although there is a clear need for additional randomized controlled trials utilizing defined and standardized outcome measures. In this review, the most commonly evaluated PPIs were mindfulness-based or gratitude-based interventions. …

The Current Burden And Future Solutions For Preoperative Cataract-Refractive Evaluation Diagnostic Devices: A Modified Delphi Study, Bonnie An Henderson, Jaime Aramberri, Robin Vann, Adi Abulafia, Margaret Ainslie-Garcia, John Berdahl, Nicole Ferko, Kjell Gunnar Gundersen, So Goto, Preeya Gupta, Samuel Multack, Elizabeth Persaud, Duna Raoof, Giacomo Savini, H John Shammas, Li Wang, Wendy Zhi Wang

Faculty, Staff and Students Publications

Purpose: To obtain consensus on the key areas of burden associated with existing devices and to understand the requirements for a comprehensive next-generation diagnostic device to be able to solve current challenges and provide more accurate prediction of intraocular lens (IOL) power and presbyopia correction IOL success.

Patients and methods: Thirteen expert refractive cataract surgeons including three steering committee (SC) members constituted the voting panel. Three rounds of voting included a Round 1 structured electronic questionnaire, Round 2 virtual face-to-face meeting, and Round 3 electronic questionnaire to obtain consensus on topics related to current limitations and future solutions for preoperative …

Advocacy Spotlight: Mda’S Legislative Priorities For 2023, Neema Katibai Jd

The Journal of the Michigan Dental Association

This article outlines the Michigan Dental Association's (MDA) legislative priorities for the year 2023. The MDA focuses on various key issues, including dental loss ratio, network leasing transparency, teledentistry policy, the state budget's impact on dental services, increasing the dental workforce, and addressing student debt relief. These priorities aim to advocate for the dental profession, enhance patient care, and ensure the dental community's well-being.

Clinical Trial Design Challenges And Opportunities For Emerging Treatments For Opioid Use Disorder: A Review, Brian D Kiluk, Bethea A Kleykamp, Sandra D Comer, Roland R Griffiths, Andrew S Huhn, Matthew W Johnson, Kyle M Kampman, Marco Pravetoni, Kenzie L Preston, Ryan Vandrey, Cecilia L Bergeria, Michael P Bogenschutz, Randall T Brown, Kelly E Dunn, Robert H Dworkin, Patrick H Finan, Peter S Hendricks, Elisabeth J Houtsmuller, Thomas R Kosten, Dustin C Lee, Frances R Levin, Aimee Mcrae-Clark, Charles L Raison, Kurt Rasmussen, Dennis C Turk, Roger D Weiss, Eric C Strain

Faculty, Staff and Students Publications

Importance: Novel treatments for opioid use disorder (OUD) are needed to address both the ongoing opioid epidemic and long-standing barriers to existing OUD treatments that target the endogenous μ-opioid receptor (MOR) system. The goal of this review is to highlight unique clinical trial design considerations for the study of emerging treatments for OUD that address targets beyond the MOR system. In November 2019, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the US Food and Drug Administration sponsored a meeting to discuss the current evidence regarding potential treatments for OUD, including cannabinoids, …

Unchoreographed Dance: Trust And Venture Into Vulnerability—Building A Plural, Organic, And Recursive Collective, Miryam Espinosa-Dulanto, Eunice Lerma, Karin A. Lewis, Vejoya Viren

Bilingual and Literacy Studies Faculty Publications

In this autoethnography, we—four Hispanic Serving Institution colleagues at the USA–Mexican frontera—share our process of building a collective where a plural, organic, vulnerable, and recursive space was created. In this space, through readings, conversations, feedings, discussions, and memories, un/anticipated stories emerge…in our unchoreographed writings, we whirl, twirl, collide, and craft our collective space, which was at once chaotic, cathartic, and sustaining.

Primary Spinal Intramedullary Anaplastic Ganglioglioma In A Pediatric Patient, Huy Dang, Abdul Basit Khan, Nisha Gadgil, Marc Prablek, Frank Y Lin, Melissa M Blessing, Guillermo Aldave, David Bauer

Faculty, Staff and Students Publications

BACKGROUND: Gangliogliomas (GGs) are rare tumors of the central nervous system composed of neoplastic neural and glial cells and are typically low-grade. Intramedullary spinal anaplastic GGs (AGG) are rare, poorly understood, and often aggressive tumors that can result in widespread progression along the craniospinal axis. Due to the rarity of these tumors, data are lacking to guide clinical and pathologic diagnosis and standard of care treatment. Here, we present a case of pediatric spinal AGG to provide information on our institutional approach to work-up and to highlight unique molecular pathology.

CASE DESCRIPTION: A 13-year-old female presented with signs of spinal …

Noise Reduction Techniques In Commercial Aircraft Cabins, Hashem Hashem

Student Works

Main sources of noise heard inside an aircraft cabin:

• Engines
• Airframe & control surfaces
• Window vibrations
• Passenger announcements & activities.

Leadership Strategies For Building High-Performing Faculty Teams In Technology-Focused Higher Education Departments, Liz Hollerman

Theses and Dissertations

This study explored the leadership strategies academic leaders of technology departments in higher education may use to build high-performing faculty teams. The objective of the study was to discover the most effective ways for fostering faculty ingenuity in curriculum reform for a technology-focused program. In addition, the literature review presents The Five Practices of Exemplary Leadership by Kouzes and Posner (2019) as the theoretical basis for this study. Literature uncovered thirteen effective leadership elements for building high-performing teams (Friedman, 2021; Katzenbach & Smith, 2005). The research subquestions for this qualitative study were organized around Kouzes and Posner's model of leadership. …

Marketization Without Marginalization? Approaches To Integration In A Dual Enrollment Magnet School, Shannon Mumolo

Theses and Dissertations

Despite the well-documented benefits of integration and Southern California’s racial, socioeconomic, and linguistic diversity, California and U.S. efforts to promote integrated magnet schools have been minimal and primarily driven by local districts. Attempts to evaluate magnet programs primarily focus on student outcomes, yet surprisingly few studies examine approaches used by school leaders to establish and achieve program outcomes. This study contributes to the knowledge and practice of magnet implementation by exploring one California high school’s efforts to establish a dual enrollment magnet program. An explanatory mixed methods case study design was used to understand how school leaders promoted student integration …

A Systematic Review On The Relationship Between Attachment Styles And Chronic Pain, Samantha M. Cohen

Theses and Dissertations

Chronic pain (CP), a leading cause of disability, is associated with addiction, physical and psychosocial impairment and tremendous financial burden. Childhood experiences contribute to the genesis of different attachment styles. Attachment theory offers a useful framework for the conceptualization of CP, with different attachment styles impacting the experience and clinical manifestations of CP. This systematic review aims to evaluate the relationship between attachment styles and CP, to investigate which attachment styles pose the greatest risk for CP, to examine how CP is expressed in the context of different attachment styles, and to gain insight regarding the treatment approach to CP. …

The Meta-Leadership Inventory: Developing A Valid And Reliable Instrument For International School Leaders, Matthew D. Wilkens

Theses and Dissertations

International school leaders must be prepared to steer their schools through ongoing crises and changes, regardless of the factors creating the crises and the need for swift change. To achieve the best possible outcomes from these dynamic situations, international school leaders must strategically deploy skills and abilities delineated by the Meta-leadership framework developed by Marcus et al.(2015). This study aimed to develop a valid and reliable instrument that measures the Meta-leadership competencies of international school leaders: the Meta-leadership Inventory for International School Leaders (MLI-ISL). This instrument development study involved a three-phase design. An initial set of items based on a …

Exploring Leaders' Sensemaking Of Emergent Global Norms For Open Science: A Mixed Methods Discourse Analysis Of Unesco’S Multistakeholder Initiative, Lisa Cuevas Shaw

Theses and Dissertations

In November 2021, all 193 United Nations Member States adopted the United Nations Educational, Scientific, and Cultural Organization’s (UNESCO) Recommendation on Open Science (UNESCO, 2021a), which signaled a shared commitment to globally recognized standards for open science. However, as with other normative instruments established by intergovernmental organizations (IGOs) such as UNESCO, the ways in which local, national, and regional leaders will implement the recommendation can and will vary (Finnemore, 1993). Top-down and bottom-up coordination across international stakeholders in the research system is critical for the framework to be effective in driving global policy implementation and enabling sustained research culture change. …

Effective Approaches To Establishing And Maintaining A Strong Therapeutic Alliance With Men: A Qualitative Systematic Review, Ferdinand Aliga

Theses and Dissertations

Consequences of mental health issues in men that are left untreated can affect a man’s partner, friends, family, and co-workers. While much research has described the efficacy of psychotherapy with this population, adult male clients may be hesitant to even start treatment. This is due to several reasons including stigma, toxic masculinity, and accessibility. To combat this, the American Psychological Association published Guidelines for Psychological Practice with Boys and Men in 2018. Research from 2005--the year the guidelines were conceived--to 2021 suggests that three therapeutic approaches are among the most effective in establishing or maintaining a therapeutic alliance. The approaches …

Transformational Leadership Strategies In U.S. Public Universities, Jason C. Hardman

Theses and Dissertations

This qualitative study explores the transformational leadership strategies used by university leaders to transform their respective institutions of higher education in the post-pandemic era. The study builds on Bass's (1985a) transformational leadership model, and the guiding research question is, "What transformational leadership strategies do university leaders use to transform university environments?" The study utilizes a narrative inquiry approach to collect and analyze data from publicly available and accessible sources. The data analysis highlights four themes of transformational leadership practices, including idealized influence, inspirational motivation, intellectual stimulation, and individualized consideration. The findings reveal that transformational leaders exhibit high moral standards, personal …

How Technology Mediated Social Learning During The Covid-19 Pandemic: A Phenomenological Case Study, Rashi Seth-Parmar

Theses and Dissertations

Due to the COVID-19 pandemic, schools in California were forced to shut their doors to students and staff during spring semester 2020. The school closures forced teachers to migrate their lessons to online platforms and forced students to learn using various online modalities. Students no longer had the traditional access to their teachers, administrators, or peers, which caused an imbalance in their social learning. This phenomenological qualitative study offers administrators and teachers best practices in fostering student social learning while utilizing distance learning or online learning specifically for K-12 students. The best practices are derived from the lived experiences of …

Couple-Based Therapeutic Interventions Aimed At Treating The Individual And Relational Impact Of Childhood Abuse, Megan A. Maguire

Theses and Dissertations

Childhood abuse can have a significant and lasting impact on an individual's mental health and relationships, including their ability to trust, communicate, and form healthy attachments. While the greater literature focuses on individual interventions to address childhood trauma, there is limited research on the potential positive impact of a couple-based therapeutic approach on outcomes of individual mental health and relationship distress. This dissertation sought to summarize empirically researched couples-based psychotherapies designed to address the effects of childhood abuse and review evidence regarding therapeutic outcomes. The dissertation implemented the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to ensure a …