Digital Commons Network^™

Effectiveness Of A Messenger Rna Vaccine Booster Dose Against Coronavirus Disease 2019 Among Us Healthcare Personnel, October 2021-July 2022, Ian D. Plumb, Nicholas M. Mohr, Melissa Hagen, Ryan Wiegand, Ghinwa Dumyati, Karisa K. Harland, Anusha Krishnadasan, Jade James Gist, Glen Abedi, Katherine E Fleming-Dutra, Nora Chea, Jane Lee, Devra Barter, Monica Brackney, Scott K. Fridkin, Lucy E. Wilson, Sara A. Lovett, Valerie Ocampo, Erin C. Phipps, Tiffanie M. Marcus, Howard A. Smithline, Peter C. Hou, Lilly C. Lee, Gregory J. Moran, Elizabeth Krebs, Mark T. Steele, Stephen C. Lim, Walter A. Schrading, Brian Chinnock, David G. Beiser, Brett Faine, John P. Haran, Utsav Nandi, Anne K. Chipman, Frank Lovecchio, David A. Talan, Tamara Pilishvili

Department of Emergency Medicine Faculty Papers

BACKGROUND: Protection against symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019 [COVID-19]) can limit transmission and the risk of post-COVID conditions, and is particularly important among healthcare personnel. However, lower vaccine effectiveness (VE) has been reported since predominance of the Omicron SARS-CoV-2 variant.

METHODS: We evaluated the VE of a monovalent messenger RNA (mRNA) booster dose against COVID-19 from October 2021 to June 2022 among US healthcare personnel. After matching case-participants with COVID-19 to control-participants by 2-week period and site, we used conditional logistic regression to estimate the VE of a booster dose compared with completing …

Acculturation And Subjective Norms Impact Non-Prescription Antibiotic Use Among Hispanic Patients In The United States, Lindsey A Laytner, Kiara Olmeda, Juanita Salinas, Osvaldo Alquicira, Susan Nash, Roger Zoorob, Michael K Paasche-Orlow, Barbara W Trautner, Larissa Grigoryan

Faculty, Staff and Students Publications

Using antibiotics without medical guidance (non-prescription antibiotic use) may contribute to antimicrobial resistance. Hispanic individuals are a growing demographic group in the United States (US) with a high prevalence of non-prescription antibiotic use. We investigated the effects of acculturation and subjective norms on Hispanic individuals’ intentions to use antibiotics without a prescription from the following sources: (1) markets in the United States (not legal), (2) other countries (abroad), (3) leftovers from previous prescriptions, and (4) friends/relatives. We surveyed self-identified Hispanic outpatients in eight clinics from January 2020 to June 2021 using the previously validated Short Acculturation Scale for Hispanics (SASH). …

A Narrative Review Of The Many Psychiatric Manifestations Of Neurosyphilis: The Great Imitator, Baneet Kaur, Deepesh Khanna

HPD Articles

Neurosyphilis is an infection of the central nervous system caused by the spirochete, Treponema pallidum. New syphilis infections have been increasing around the world each year. This disease was much of a concern in the pre-penicillin era, where when left untreated many cases progressed to tertiary syphilis which can commonly manifest as neurosyphilis. Of particular interest, neurosyphilis has been linked to masquerading itself as various psychiatric conditions. This narrative review focuses on exploring psychiatric manifestations of neurosyphilis as well as the importance of screening in psychiatric settings and clinicians maintaining high clinical suspicion of the disease. A systematic search …

An Evolutionary Pathway For Coping With Emerging Infectious Disease, Scott Lyell Gardner, Daniel R. Brooks, Walter A. Boeger, Eric P. Hoberg

Zea E-Books Collection

Emerging infectious disease (EID) represents an existential threat to humanity. EIDs are increasing in frequency and impact because of climate change and other human activities. We are losing the battle against EIDs because of improper assessment of the risk of EID. This stems from adherence to a failed paradigm of pathogen-host associations that suggests EIDs ought to be both unpredictable and rare. That, in turn, leads to policies suggesting that crisis response is the best we can do. Real-time and phylogenetic assessments show EIDs to be neither rare nor unpredictable—this is the parasite paradox that shows the failures of the …

What Is Microbial Dormancy?, Mark D. Mcdonald, Carlos Owusu-Ansah, Jared B. Ellenbogen, Zachary D. Malone, Michael P. Ricketts, Steve E. Frolking, Jessica Gilman Ernakovich, Michael Ibba, Sarah C. Bagby, J. L. Weissman

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Life can be stressful. One way to deal with stress is to simply wait it out. Microbes do this by entering a state of reduced activity and increased resistance commonly called ‘dormancy’. But what is dormancy? Different scientific disciplines emphasize distinct traits and phenotypic ranges in defining dormancy for their microbial species and system-specific questions of interest. Here, we propose a unified definition of microbial dormancy, using a broad framework to place earlier discipline-specific definitions in a new context. We then discuss how this new definition and framework may improve our ability to investigate dormancy using multi-omics tools. Finally, we …

Heterogeneity Of Human Tissue-Resident Lymphocytes, Natalia Jaeger

Arts & Sciences Graduate Student Theses and Dissertations

The immune system plays a critical role in maintaining tissue homeostasis and defending against pathogens. Recent discoveries have highlighted the significance of tissue-resident memory T cells (TRM) and Innate Lymphoid Cells (ILCs) in tissue immunity. TRM exhibit memory-like properties, persist long-term in various tissues, and express markers such as CD69, CD103, and transcription factors like Hobit and Blimp-1. Similarly, ILCs, considered the innate counterparts of T cells, are abundant at barrier organs and mucosal sites, sharing similar markers and transcriptional factors with TRM, and rapidly responding to insults. Unraveling the heterogeneity and function of tissue-resident lymphocytes is crucial for understanding …

Prospective Assessment Of Inter-Rater Reliability Of A Neonatal Adverse Event Severity Scale., Thomas Salaets, Thierry Lacaze-Masmonteil, Isamu Hokuto, Cheri Gauldin, Amjad Taha, Anne Smits, Liesbeth Thewissen, Ilse Van Horebeek, Armuchou Shoraisham, Khorshid Mohammad, Manami Suzuki, Shiori Komachi, Kurt Michels, Mark A. Turner, Karel Allegaert, Tamorah Lewis

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: To ensure the quality of clinical trial safety data, universal data standards are required. In 2019 the International Neonatal Consortium (INC) published a neonatal adverse event severity scale (NAESS) to standardize the reporting of adverse event (AE) severity. In this study the reliability of AE severity grading with INC NAESS was prospectively assessed in a real-world setting. Methods: Severity of AEs was assessed by two independent observers at each of four centers across the world. In each center two series of 30 neonatal adverse events were assessed by both observers: in a first phase with a generic (Common Terminology …

The Public Health Impact Of Paxlovid Covid-19 Treatment In The United States, Yuan Bai, Zhanwei Du, Lin Wang, Eric H. Y. Lau, Isaac Fung, Petter Holme, Ben Cowling, Alison Galvani, Robert Krug, Lauren Ancel Meyers

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

The antiviral drug Paxlovid has been shown to rapidly reduce viral load. Coupled with vaccination, timely administration of safe and effective antivirals could provide a path towards managing COVID-19 without restrictive non-pharmaceutical measures. Here, we estimate the population-level impacts of expanding treatment with Paxlovid in the US using a multi-scale mathematical model of SARS-CoV-2 transmission that incorporates the within-host viral load dynamics of the Omicron variant. We find that, under a low transmission scenario (Re∼1.2) treating 20% of symptomatic cases would be life and cost saving, leading to an estimated 0.26 (95% CrI: 0.03, 0.59) million hospitalizations averted, 30.61 (95% …

Medical School Watercooler Newsletter - September 6, 2023, Lindsey Lyle

Watercooler Newsletter

This is the September 6, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Meet a Med Student: Cana Brown
• USA scientists awarded national grant to study body's innate immune response to infection
• Medical student to present tick transmission research at national conference

September 6, 2023 General Faculty Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Exploring Nurse Faculty Decisions Related To Virtual Simulation During A Global Pandemic: A Quantitative Descriptive Study, Karen Braccialarghe

Dissertations

This research evaluates academic nurse faculty' decisions while implementing virtual simulation as a teaching method before and during the COVID-19 pandemic. Secondary purposes of this study were to explore nurse faculty perceptions of the effectiveness of virtual simulation, the barriers and challenges faced while implementing virtual simulation, and perceived effectiveness of student learning outcomes during the COVID-19 pandemic while utilizing virtual simulation. A survey, the Virtual Simulation Implementation Evaluation Tool (Braccialarghe, 2021) was developed by the researcher to answer the research questions. The tool was sent to nine simulation experts to rate content validity.

A convenience sample of nurse faculty …

Sex-Biased T-Cell Exhaustion Drives Differential Immune Responses In Glioblastoma, Manmeet Ahluwalia

All Publications

Sex differences in glioblastoma (GBM) incidence and outcome are well recognized, and emerging evidence suggests that these extend to genetic/epigenetic and cellular differences, including immune responses. However, the mechanisms driving immunologic sex differences are not fully understood. Here, we demonstrate that T cells play a critical role in driving GBM sex differences. Male mice exhibited accelerated tumor growth, with decreased frequency and increased exhaustion of CD8+ T cells in the tumor. Furthermore, a higher frequency of progenitor exhausted T cells was found in males, with improved responsiveness to anti-PD-1 treatment. Moreover, increased T-cell exhaustion was observed in male GBM patients. …

Is Β-Lactamase Testing Acceptably Accurate For Predicting Haemophilus Influenzae Susceptibility To Β-Lactams? Epidemiological Data From Philadelphia, Usa, 2017–2023, Arianna B. Morton, Chairut Vareechon, Matthew A. Pettengill

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

No abstract provided.

Development Of Antiviral Peptidomimetics, Songyi Xue

USF Tampa Graduate Theses and Dissertations

Protein-protein interactions (PPIs) are essential for biological processes and are associated with a number of diseases, including cancer, infectious diseases, and neurodegenerative diseases. As a result, modulation of PPIs has been recognized as one of the most promising strategies to develop the novel drugs. Peptide modulators always exhibit higher specificity and affinities with targets than small compounds or monoclonal antibodies, but their broad medicinal effectiveness is constrained by their poor bioavailability and biostability. Peptidomimetics, which have been developed to mimic the structure as well as function of bioactive peptides and proteins, have shown excellent potential in protein surface mimicry and …

Gardner-Webb Alumna Dr. Carrie Mae Long Receives Prestigious Award, Office Of University Communications

Gardner-Webb NewsCenter Archive

Dr. Carrie Mae Long, a 2011 Gardner-Webb University alumna with a degree in biology, is the winner of the Pathogens 2022 Young Investigator Award (https://www.mdpi.com/about/announcements/6053). Pathogens, an international, peerreviewed, open access journal, presents this honor annually to recognize excellence in the field.

The Molecular Biophysics Of Extracellular Vimentin And Its Role In Pathogen–Host Interactions, Sepideh Parvanian, Leila S. Coelho-Rato, John E. Eriksson, Alison E. Patteson

Physics - All Scholarship

Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with …

Structured Ethical Review For Wastewater-Based Testing In Support Of Public Health, Devin A. Bowes, Amanda Darling, Erin M. Driver, Devrim Kaya, Rasha Maal-Bared, Lisa M. Lee, Kenneth Goodman, Sangeet Adhikari, Srijan Aggarwal, Aaron Bivins, Zuzana Bohrerova, Alasdair Cohen, Claire Duvallet, Rasha A. Elnimeiry, Justin M. Hutchison, Vikram Kapoor, Ishi Keenum, Fangqiong Ling, Deborah Sills, Ananda Tiwari, Peter Vikesland, Ryan Ziels, Cresten Mansfeldt

Faculty Publications

Wastewater-based testing (WBT) for SARS-CoV-2 has rapidly expanded over the past three years due to its ability to provide a comprehensive measurement of disease prevalence independent of clinical testing. The development and simultaneous application of WBT measured biomarkers for research activities and for the pursuit of public health goals, both areas with well-established ethical frameworks. Currently, WBT practitioners do not employ a standardized ethical review process, introducing the potential for adverse outcomes for WBT professionals and community members. To address this deficiency, an interdisciplinary workshop developed a framework for a structured ethical review of WBT. The workshop employed a consensus …

Strategies For Strengthening The Resilience Of Public Health Systems For Pandemics, Disasters, And Other Emergencies, Benjamin Ryan, Mayumi Kako, Rok Fink, Perihan Şimşek, Paul Barach, Jose Acosta, Sanjaya Bhatia, Mark Brickhouse, Matthew Fendt, Alicia Fontenot, Nahuel Arenas Garcia, Shelby Garner, Abdülkadir Gunduz, D Mike Hardin, Tim Hatch, Lashonda Malrey-Horne, Makiko Macdermot, Ryoma Kayano, Joshua Mckone, Chaverle Noel, Shuhei Nomura, Jeremy Novak, Andrew Stricklin, Raymond Swienton, Ismail Tayfur, Bryan Brooks

College of Population Health Faculty Papers

OBJECTIVE: The aim of this study was to identify and prioritize strategies for strengthening public health system resilience for pandemics, disasters, and other emergencies using a scorecard approach.

METHODS: The United Nations Public Health System Resilience Scorecard (Scorecard) was applied across 5 workshops in Slovenia, Turkey, and the United States of America. The workshops focused on participants reviewing and discussing 23 questions/indicators. A Likert type scale was used for scoring with zero being the lowest and 5 the highest. The workshop scores were analyzed and discussed by participants to prioritize areas of need and develop resilience strategies. Data from all …

An Implementation Of The Method Of Moments On Chemical Systems With Constant And Time-Dependent Rates, Emmanuel O. Adara, Roger B. Sidje

Northeast Journal of Complex Systems (NEJCS)

Among numerical techniques used to facilitate the analysis of biochemical reactions, we can use the method of moments to directly approximate statistics such as the mean numbers of molecules. The method is computationally viable in time and memory, compared to solving the chemical master equation (CME) which is notoriously expensive. In this study, we apply the method of moments to a chemical system with a constant rate representing a vascular endothelial growth factor (VEGF) model, as well as another system with time-dependent propensities representing the susceptible, infected, and recovered (SIR) model with periodic contact rate. We assess the accuracy of …

Autoantibodies Neutralizing Type I Ifns Underlie West Nile Virus Encephalitis In ∼40% Of Patients, Adrian Gervais, Francesca Rovida, Maria Antonietta Avanzini, Stefania Croce, Astrid Marchal, Shih-Ching Lin, Alessandro Ferrari, Christian W Thorball, Orianne Constant, Tom Le Voyer, Quentin Philippot, Jérémie Rosain, Micol Angelini, Malena Pérez Lorenzo, Lucy Bizien, Cristian Achille, Francesca Trespidi, Elisa Burdino, Irene Cassaniti, Daniele Lilleri, Chiara Fornara, José Camilla Sammartino, Danilo Cereda, Chiara Marrocu, Antonio Piralla, Chiara Valsecchi, Stefano Ricagno, Paola Cogo, Olaf Neth, Inés Marín-Cruz, Monia Pacenti, Alessandro Sinigaglia, Marta Trevisan, Andrea Volpe, Antonio Marzollo, Francesca Conti, Tiziana Lazzarotto, Andrea Pession, Pierluigi Viale, Jacques Fellay, Stefano Ghirardello, Mélodie Aubart, Valeria Ghisetti, Alessandro Aiuti, Emmanuelle Jouanguy, Paul Bastard, Elena Percivalle, Fausto Baldanti, Anne Puel, Margaret R Macdonald, Charles M Rice, Giada Rossini, Kristy O Murray, Yannick Simonin, Anna Nagy, Luisa Barzon, Laurent Abel, Michael S Diamond, Aurélie Cobat, Shen-Ying Zhang, Jean-Laurent Casanova, Alessandro Borghesi

Faculty, Staff and Students Publications

Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis in <1% of infected individuals. We show that ∼35% of patients hospitalized for WNV disease (WNVD) in six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or -ω. The prevalence of these antibodies is highest in patients with encephalitis (∼40%), and that in individuals with silent WNV infection is as low as that in the general population. The odds ratios for WNVD in individuals with these auto-Abs relative to those without them in the general population range from 19.0 (95% CI 15.0–24.0, P value <10–15) for auto-Abs neutralizing only 100 pg/ml IFN-α and/or IFN-ω to 127.4 (CI 87.1–186.4, P value <10–15) for auto-Abs neutralizing both IFN-α and IFN-ω at a concentration of 10 ng/ml. These antibodies block the protective effect of IFN-α in Vero cells infected with WNV in vitro. Auto-Abs neutralizing IFN-α and/or IFN-ω underlie ∼40% of cases of WNV encephalitis.

Trends And Associated Factors Of Hiv, Hcv And Syphilis Infection Among Different Drug Users In The China-Vietnam Border Area: An 11-Year Cross-Sectional Study (2010-2020), Tong Luo, Zhaosen Lin, Zhenxian Wu, Ping Cen, Aidan Nong, Rongye Huang, Jianhua Che, Fengfeng Liang, Yuan Yang, Jie Liu, Li Huang, Jie Cai, Yanyun Ou, Li Ye, Lijuan Bao, Bingyu Liang, Hao Liang

Faculty, Staff and Student Publications

BACKGROUND: Data on recent human immunodeficiency virus (HIV), hepatitis C virus (HCV) and syphilis prevalence among drug users in the Southwest China are sparse despite the high burden of drug use. This study aims at assessing the prevalence trends and related factors of HIV, HCV and syphilis infection among different drug users in the China-Vietnam border area.

METHODS: A continuous cross-sectional survey was conducted among drug users from 2010 to 2020 in the China-Vietnam border area. Chi-square trend tests were used to assess the trend of HIV, HCV and syphilis prevalence and the proportion for drug type used by drug …

Autoantibodies Neutralizing Type I Ifns Underlie West Nile Virus Encephalitis In ∼40% Of Patients, Adrian Gervais, Shih-Ching Lin, Michael S Diamond, Et Al.

2020-Current year OA Pubs

Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis in <1% of infected individuals. We show that ∼35% of patients hospitalized for WNV disease (WNVD) in six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or -ω. The prevalence of these antibodies is highest in patients with encephalitis (∼40%), and that in individuals with silent WNV infection is as low as that in the general population. The odds ratios for WNVD in individuals with these auto-Abs relative to those without them in the general population range from 19.0 (95% CI 15.0-24.0, P value <10-15) for auto-Abs neutralizing only 100 pg/ml IFN-α and/or IFN-ω to 127.4 (CI 87.1-186.4, P value <10-15) for auto-Abs neutralizing both IFN-α and IFN-ω at a concentration of 10 ng/ml. These antibodies block the protective effect of IFN-α in Vero cells infected with WNV in vitro. Auto-Abs neutralizing IFN-α and/or IFN-ω underlie ∼40% of cases of WNV encephalitis.

Hemophagocytic Lymphohistiocytosis And Pancreatic Cancer: A Rare Association., Ali Jaan, Farhan Khalid, Abdullah M. Firoze Ahmed, Ahmed Salman, Trisha Meghal, Doantrang Du

Journal of Community Hospital Internal Medicine Perspectives

Introduction: Hemophagocytic lymphohistiocytosis (HLH) or hemophagocytic syndrome (HPS) is a life-threatening and relatively rare condition that usually presents as a multisystem febrile illness. It is associated with excessive activation of the immune system and hypercytokinemia, leading to an unregulated aggregation of macrophages and lymphocytes. Here, we present the first likely case of HLH with metastatic pancreatic carcinoma being the underlying etiology. Case: A 44-year-old male with past medical history significant for heart transplant for which he was on tacrolimus, End-Stage Renal Disease (ESRD) on hemodialysis, recently treated CMV viremia, and necrotizing pancreatitis presented to the emergency with complaints of chills, …

Rhino-Cerebral Aspergillosis In An Immunocompetent Patient, Jisun Won, Carolina Severiche Mena, Joseph Glowacki, Dimple Patel

Journal of Community Hospital Internal Medicine Perspectives

Rhino-cerebral aspergillosis is a rare phenomenon describing a contiguous spread of Aspergillus species from the paranasal sinuses to the intracranial space. In this case report, we describe a case of invasive rhino-cerebral aspergillosis arising in the setting of prolonged intranasal steroid use in an 81-year-old patient with chronic sinusitis. This case report emphasizes the importance of recognizing steroid use as a risk factor for invasive aspergillosis in otherwise immunocompetent individuals.

Coronary Artery Dissection And Myocarditis Caused By Eosinophilic Granulomatosis With Polyangiitis (Egpa): A Case Report, Vidhyalakshmy Vivek, Sumeet Yadav, Hariprasad Reddy Korsapati, Mikael Mir, Shika Jain, Abbas B. Jama, Setu Trivedi, Qiping Xu, Namratha Seetharam Meda, Syed Ali, Anwar Khedr, Esraa Hassan, Noura Attallah, Harsha Patnaik, Sri Usha Jeevani Obulareddy, Ibtisam Rauf, Aishwarya Reddy Korsapati, Salim Surani, Syed Anjum Khan, Nitesh Kumar Jain, Hasnain Bawaadam

Journal of Community Hospital Internal Medicine Perspectives

Eosinophilic granulomatosis with polyangiitis (EGPA) also referred to as Churg-Strauss syndrome is a rare vasculitis of the small to medium vessels. We present a rare case of acute coronary artery dissection brought on by EGPA, which generally has a poor prognosis. A 41-year-old male with history of bronchial asthma presented to the emergency room with a 2-week history of dyspnea, cough with clear phlegm, and fever. For the past eight months he had experienced episodes with similar symptoms relieved by steroids. CT chest showed bilateral upper lobe patchy opacities with extensive workup for infectious etiology being negative. He had peripheral …

Beyond Misinformation: The Misrepresentation And Misappropriation Of Research, Winn W. Wasson

Librarian Publications

The contemporary information landscape has produced numerous incidents of researchers having their research misunderstood, misrepresented, or misappropriated—or worse, being subjected to intimidation and harassment—by individuals or groups who seek to cherry-pick evidence in support of ideological agendas or who wish to suppress evidence that counters those same agendas. While the covid-19 pandemic elevated these tactics in their frequency, visibility, and intensity, this phenomenon did not start or end with the pandemic. To help prepare current and future researchers for the possibility that their research might be misrepresented, misappropriated, or politicized in other ways by ideologically motivated individuals or groups, Syracuse …

The Code Of Life And Death, Braden R. Leach

Notre Dame Journal on Emerging Technologies

Biotechnology is advancing at an astonishing clip, but our safeguards are decades behind. Given new technologies and economies of scale, it is possible for nefarious actors to assemble deadly viruses from scratch using synthetic DNA ordered off the internet. The Select Agents statute helps to prevent malicious actors from acquiring dangerous pathogens, but the Department of Health and Human Services has interpreted it to not cover synthetic DNA. Recognizing the gap, HHS issued guidance recommending that gene synthesis companies verify their customers to ensure their legitimacy and screen genetic sequences for matches to pathogen sequences. Unsurprisingly, voluntary guidance has not …

A Numerical Confirmation Of A Fractional Seitr For Influenza Model Efficiency, Dalal Khalid Almutairi, Mohamed A.Abdoon, Mohammed Berir, Rania Saadeh, Ahmad Qazza

Applied Mathematics & Information Sciences

The main idea of this study is to reduce the number of susceptible to infections so that ill patients can receive prompt hospitalization. Fractional SEITR was introduced for this purpose. Both endemic and disease-free equilibrium’s’ durability was examined. The fundamental reproduction number of the fractional SEITR model was determined using the next-generation matrix method. Our analytical results were supported by numerical models. Here, a graphical representation of the fractional order model is presented to validate the conclusion through numerical simulation. We have come to the conclusion that the fractional order model is more precise and provides more information about the …

A Probabilistic Siri Epidemic Model Incorporating Incidence Capping And Logistic Population Expansion, Soulaimane Aznague, Mourad El Idrissi, Abdeladim Nait Brahim, Bilal Harchaoui, Saloua Boutouil, Adel Settati

Applied Mathematics & Information Sciences

This study presents a newly developed stochastic SIRI epidemic model, which combines logistic growth with a saturation incidence rate. This research mainly examines the presence and uniqueness of positive solutions within the formulated model. Furthermore, we aim to analyze the long-term performance of the system and provide valuable insights into disease extinction in a population. Our investigation delves into the conditions required for disease extinction, which are crucial in predicting and controlling the spread of deadly diseases. To substantiate our assertions, we have devised a stochastic Lyapunov function, which serves as a robust mathematical framework for demonstrating the presence of …

Optimal Control Analysis Of The Dynamics Of Covid-19 With Application To Ethiopian Data, Temesgen Duresa Keno, Fekadu Mosisa Legesse, Ebisa Olana Bajira

Applied Mathematics & Information Sciences

In this paper, we proposed an optimal control of the COVID-19 transmission dynamics. First, we investigated system features such as solution boundedness, positivity, disease-free and endemic equilibrium, and the local and global stability of equilibrium points. Besides, a disease-free equilibrium point is globally asymptotically stable if the basic reproduction number is less than one, and an endemic equilibrium point exists otherwise. Secondly, we have shown the sensitivity analysis of the basic reproduction number. Also the model is then fitted using COVID-19 infected reported in Ethiopia from February 1,2023 to March 2,2023. The values of model parameters are then estimated from …