Digital Commons Network^™

Impact Of A Novel Multi-Specialist Telemedicine Consultation Program Model Of Care For Homebound Older Adults, Samir K. Sinha Dr, Kristina Marie Kokorelias, Nicoda Foster, Pauline Kabitsis, Alfiya Mukharyamova, Mary Ann Hamelin, Nga Truong, Anna Grosse Dr, Janny Lee

Journal of Geriatric Emergency Medicine

BACKGROUND: In 2015, a centralised Multi-Specialist Telemedicine (TM) Consultation Program was established to improve access to specialist care and enhance continuity of care for homebound older adults in Toronto, Canada. Community-dwelling patients were referred to the program by their primary care providers (PCP), treating specialists, and inpatient physicians for specialist-led post hospital discharge follow-up care. A clinical nurse specialist (CNS) thereafter collaborated with hospital-based consulting specialists, utilizing videoconferencing technology to facilitate consultations and follow-up visits for homebound patients

METHODS: We conducted a retrospective observational study of the overall intervention including patient characteristics and the number/type of consultations provided by analyzing …

Learning Science: Physical And Life Sciences In Curricula Across U.S. Schools Of Nursing, Valerie C. Sauda

Dissertations

Nursing educators are being challenged to provide curriculum that meets the changing healthcare environment and demand for creative, innovative nurses to assist in transforming healthcare into the future (Benner, Sutphen, Leonard, & Day, 2010; Institute Of Medicine, 2011). The liberal education provided within a baccalaureate of science in nursing (BSN) degree program provides a diversity of courses within the curriculum, including courses in the natural, physical, mathematical, and social sciences (American Association of Colleges of Nursing [AACN], 2008). Although nursing programs have included science courses in curriculum since the early 1900s (Nutting & Dock, 1907), there is lack of nursing …

Specific Polysaccharide Antibody Deficiency, Daniel M Musher

Faculty, Staff and Students Publications

No abstract provided.

A Bibliometric Analysis Of The Rise Of Chatgpt In Medical Research, Nikki M. Barrington, Nithin Gupta, Basel Musmar, David Doyle, Nicholas Panico, Nikhil Godbole, Taylor K. Reardon, Randy S. D'Amico

Neurology Articles

The rapid emergence of publicly accessible artificial intelligence platforms such as large language models (LLMs) has led to an equally rapid increase in articles exploring their potential benefits and risks. We performed a bibliometric analysis of ChatGPT literature in medicine and science to better understand publication trends and knowledge gaps. Following title, abstract, and keyword searches of PubMed, Embase, Scopus, and Web of Science databases for ChatGPT articles published in the medical field, articles were screened for inclusion and exclusion criteria. Data were extracted from included articles, with citation counts obtained from PubMed and journal metrics obtained from Clarivate Journal …

Single-Cell Transcriptomics Of Mtb/Hiv Co-Infection, Smita Kulkarni, Janice J. Endsley, Zhao Lai, Todd Bradley, Riti Sharan

Manuscripts, Articles, Book Chapters and Other Papers

Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) co-infection continues to pose a significant healthcare burden. HIV co-infection during TB predisposes the host to the reactivation of latent TB infection (LTBI), worsening disease conditions and mortality. There is a lack of biomarkers of LTBI reactivation and/or immune-related transcriptional signatures to distinguish active TB from LTBI and predict TB reactivation upon HIV co-infection. Characterizing individual cells using next-generation sequencing-based technologies has facilitated novel biological discoveries about infectious diseases, including TB and HIV pathogenesis. Compared to the more conventional sequencing techniques that provide a bulk assessment, single-cell RNA sequencing (scRNA-seq) can reveal complex …

Pattern Of Antibiotic Sensitivity In Ear Isolates: A Retrospective Study Of Ear Infection In National Ear Care Centre, Kaduna, Astaharam Ardo Jabbo, Isaac Agyigra, Maryam Ibrahim Rimi, Zainab Yakubu Abbas, Maryam Usman Fari, Muhammad Kabir, Kelechi Ncheta Nkwazema

Bulletin of Faculty of Pharmacy Cairo University

Background: Ear infection is a health problem amongst all ages globally. The high rate of antibiotic-resistance has thus worsened this problem along-side paucity of data on ear infection in northern Nigeria. The aim of this study is to determine the bacterial isolates and their drug susceptibility patterns from patients who had ear infection. Method: A retrospective study of a reviewed of records of ear swab samples collected at the Medical Laboratory Department of National Ear Care Centre (NECC) from the period of January 2014 to December 2016. Sample were cultured on MacConkey, blood and chocolate agars and subsequent biochemical analyses. …

Identifying Grey Areas Of Brain Fungal Pathogenesis Using 3-D Cerebral Organoids, Aswathi Ramesh, Peralam Yegneswaran Prakash, Kavitha Saravu, Kavitha S Shettigar, Dinesh Upadhya

KCACON 2023

No abstract provided.

Mathematical Analysis Of Hiv/Htlv-I Co-Infection Model With Saturated Incidence Rate, A. A. Abdellatif, E. Dahy, A. M. Zahran

Information Sciences Letters

Direct contact with specific contaminated body fluids is how both the human immunodeficiency virus (HIV) and the human T-lymphotropic virus type I (HTLV-I) are transmitted from one person to another. Therefore, the two viruses can co-infect same person. In the literature all the HIV/HTLV-I co-infection models assume that the infection rate is given by bilinear incidence. However, for high concentration of pathogens, the bilinear incidence is not suitable. Therefore, this study will focus on the dynamical behavior of an HIV/HTLV-I co-infection model with saturated incidence. The model includes the effect of Cytotoxic T lymphocytes (CTL) immune response. Through the non-negativity …

Baseline Immune States (Bis) Associated With Vaccine Responsiveness And Factors That Shape The Bis., Djamel Nehar-Belaid, Mark Sokolowski, Sathyabaarathi Ravichandran, Jacques Banchereau, Damien Chaussabel, Duygu Ucar

Faculty Research 2023

Vaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in single-cell biology have been instrumental in uncovering pre-vaccination immune cell types and genomic features (i.e., the baseline immune state, BIS) that have been associated with vaccine responsiveness. …

Hsc Connects Newsletter - September 15, 2023, Unm Hsc Communications

HSC Connects Newsletters

Weekly newsletter of the UNM Health Sciences Center.

Molecular Characterization Of Streptococcus Pneumoniae Causing Disease Among Children In Nigeria During The Introduction Of Pcv10 (Gsk), Stephanie W. Lo, Paulina A. Hawkins, Binta Jibir, Fatimah Hassan-Hanga, Mahmoud Gambo, Rasaq Olaosebikan, Grace Olanipekun, Huda Munir, Nicholas Kocmich, Amy Rezac-Elgohary, Safiya Gambo, Danstan Bagenda, Paul Fey, Robert F. Breiman, Lesley Mcgee, Stephen D. Bentley, Stephen K. Obaro, Community Acquired Pneumonia And Invasive Bacterial Disease Capibd Consortium

Student Papers, Posters & Projects

Streptococcus pneumoniae (pneumococcus) is a leading vaccine-preventable cause of childhood invasive disease. Nigeria has the second highest pneumococcal disease burden globally, with an estimated ~49 000 child deaths caused by pneumococcal infections each year. Ten-valent pneumococcal conjugate vaccine (GSK; PCV10) was introduced in December 2014 in a phased approach. However, few studies have characterized the disease-causing pneumococci from Nigeria. This study assessed the prevalence of serotypes, antibiotic susceptibility and genomic lineages using whole genome sequencing and identified lineages that could potentially escape PCV10 (GSK). We also investigated the potential differences in pneumococcal lineage features between children with and without sickle …

The Impact Of Insomnia Symptoms On Obesity Among Mexicans Aged 50 And Older, Kanwal N Momin, Connor Sheehan, Rafael Samper-Ternent, David S López, Rebeca Wong, Sadaf Arefi Milani

Faculty, Staff and Student Publications

OBJECTIVE: To examine the association between insomnia and obesity in Mexican adults aged 50 and older.

MATERIALS AND METHODS: We used data from the Mexican Health and Aging Study (2015-2018). Self-reported insomnia was measured using the modified insomnia severity index with scores ranging from zero to six. Obesity was categorized using body mass index (BMI ≥ 30 kg/m2). We used generalized estimating equations to assess the association between insomnia and obesity over three years.

RESULTS: Insomnia was associated with obesity (odds ratio [OR]: 1.06, 95% confidence interval [CI]: 1.01,1.11), among those with no obesity at baseline. Among those with obesity, …

Ifn-Λ Derived From Nonsusceptible Enterocytes Acts On Tuft Cells To Limit Persistent Norovirus, Harshad Ingle, Heyde Makimaa, Somya Aggarwal, Hongju Deng, Lynne Foster, Yuhao Li, Elizabeth A Kennedy, Stefan T Peterson, Craig B Wilen, Sanghyun Lee, Mehul S Suthar, Megan T Baldridge

2020-Current year OA Pubs

Norovirus is a leading cause of epidemic viral gastroenteritis, with no currently approved vaccines or antivirals. Murine norovirus (MNoV) is a well-characterized model of norovirus pathogenesis in vivo, and persistent strains exhibit lifelong intestinal infection. Interferon-λ (IFN-λ) is a potent antiviral that rapidly cures MNoV. We previously demonstrated that IFN-λ signaling in intestinal epithelial cells (IECs) controls persistent MNoV, and here demonstrate that IFN-λ acts on tuft cells, the exclusive site of MNoV persistence, to limit infection. While interrogating the source of IFN-λ to regulate MNoV, we confirmed that MDA5-MAVS signaling, required for IFN-λ induction to MNoV in vitro, controls …

Hematopoietic Stem And Progenitor Cells Confer Cross-Protective Trained Immunity In Mouse Models, Bailee N Kain, Brandon T Tran, Pamela N Luna, Ruoqiong Cao, Duy T Le, Marcus A Florez, Laure Maneix, Jack D Toups, Daniel E Morales-Mantilla, Scott Koh, Hyojeong Han, Roman Jaksik, Yun Huang, Andre Catic, Chad A Shaw, Katherine Y King

Duncan NRI Faculty and Staff Publications

Recent studies suggest that infection reprograms hematopoietic stem and progenitor cells (HSPCs) to enhance innate immune responses upon secondary infectious challenge, a process called “trained immunity.” However, the specificity and cell types responsible for this response remain poorly defined. We established a model of trained immunity in mice in response to Mycobacterium avium infection. scRNA-seq analysis revealed that HSPCs activate interferon gamma-response genes heterogeneously upon primary challenge, while rare cell populations expand. Macrophages derived from trained HSPCs demonstrated enhanced bacterial killing and metabolism, and a single dose of recombinant interferon gamma exposure was sufficient to induce similar training. Mice transplanted …

Immunosuppression And Opportunistic Infections: A Rare Case Report Of Nocardia Osteomyelitis Of The Pelvis, Carlos Torres-Viera, Kebir Bedran

All Publications

Patients with a long-standing history of immunosuppression are at significantly increased risk of opportunistic infections. One such group of organisms that may cause these types of infections includes the Nocardia genus, a gram-positive, filamentous rod that demonstrates a branching pattern, is ureaseproducing and has acid-fast properties. The disease profile of Nocardia varies with manifestations ranging from cutaneous infection to severe pulmonary or central nervous system (CNS) infections, and rarely, osteomyelitis. In this case report, we present an 87-year-old female with persistent left gluteal and lumbar pain, generalized body aches, chills, and fevers diagnosed with Nocardia asiatica osteomyelitis of the pelvis, …

No Antibiotic Ever (Nae) Versus Conventional Broiler Production: It’S Complicated, Marcos H. Rostagno

Proceedings of the Arkansas Nutrition Conference

Broiler production has evolved significantly over the years to meet a constant growing demand for animal protein. Rooted on major advances in genetics, facilities and environmental conditions, management, and specially, in nutrition and health, the U.S. broiler industry improved tremendously in productivity and efficiency, clearly demonstrated by a marked reduction of the average market age (i.e., days to market), while significantly increasing average market weight, breast meat yield and feed efficiency (National Chicken Council, 2023). For decades, conventional broiler production was dominant, with extensive use of antibiotics to promote growth and manage disease challenges (prevention and control). However, concerns over …

Knowledge And Performance On Diabetes Control Among Primary Health Workers: A Baseline Survey Of Quasi Experimental Study In Naypyitaw, Myanmar, Kyi Thar, Sathirakorn Pongpanich, Min New Tun, Zaw Myo Aung

Journal of Health Research

Background: Diabetes is a growing public health problem. Due to a paradigm shift in diabetes control from hospitals to communities, improving the knowledge and performance of primary health care (PHC) providers with regards to diabetes is essential. Although Myanmar has a high prevalence of diabetes, the knowledge and performance of PHC providers has not been properly assessed before. This study assessed PHC knowledge and performance on diabetes control in two townships in Naypyitaw, Myanmar.

Methods: In this cross-sessional descriptive study, PHC providers, including midwives, lady health visitors (female nurse supervisors), and public health supervisors were selected. Their socio-demographic variables, as …

Medical School Watercooler Newsletter - September 14, 2023, Lindsey Lyle

Watercooler Newsletter

This is the September 14, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Register now: USA Health Game day set for Oct.17
• Whiddon college of medicine alumnus joins orthopedic surgery faculty
• Senior medical students named to Alpha Omega Alpha Honor Medical Society
• Lunch & learn session to focus on promotion and tenure
• USA health names new chair of internal medicine

An Incidental Finding Of A Glucagon-Like Peptide 1 (Glp-1)-Induced Acute Kidney Injury: A Case Report., Andy Espino Aleman, Erik Aleman Espino, Claudia Aleman Oliva, Hamlet Monteagudo, Odalys Frontela

HPD Articles

Acute kidney injury (AKI) involves a rapid decline in kidney function, classified into prerenal, intrarenal, and postrenal causes. Drug-induced AKI's complex pathophysiology includes altered hemodynamics, inflammation, crystal deposition, hemolysis, and rhabdomyolysis. This report details a 42-year-old female with hypertension and diabetes who, following a dog bite, exhibited reduced kidney function (GFR: 16 mL/min/1.73m

The Lasting Effects Of Covid-19 On The Progression Of Metabolic Dysfunction-Associated Steatotic Liver Disease, Sean Backer, Deepesh Khanna

HPD Articles

It is estimated that around 30% of the population living in Western countries has metabolic dysfunctionassociated steatotic liver disease (MASLD), a spectrum of pathology (not attributed to alcohol/substance intake) initiated by steatosis and progression toward inflammation and irreversible fibrosis metabolic dysfunction-associated steatohepatitis (MASH). With inflammation being a key component of the transition to MASH, it raises the question of whether the ongoing COVID-19 pandemic, which has notoriously induced hyperinflammatory states, may influence the progression of MASLD. Specifically, it remains unclear if the potential chronic sequelae of COVID-19 in patients who recovered from it may increase the predisposition for MASH. Since …

Crisis In South Carolina: A Phenomenological Study Examining Teacher Attrition Through The Experiences Of Educators Before And During The Covid-19 Pandemic, Kimberley Kristin Devers

Student Theses and Dissertations

As the COVID-19 pandemic ended, the number of teachers leaving the profession soared resulting in a teacher shortage that is crippling schools. Public education is faced with unstaffed classrooms, uncertified teachers, and students missing quality instruction. The purpose of this phenomenological study is to illuminate the experiences before and during the COVID-19 pandemic that led to educators in South Carolina exiting the profession. Using Maslach’s burnout theory as a guiding theoretical framework, qualitative data was collected during ten in-depth interviews with former South Carolina educators. Ten participants were chosen using purposive sampling and the following selection criteria: at least eight …

Development Of A Sensitive Microplate Assay For Characterizing Rna Methyltransferase Activity: Implications For Epitranscriptomics And Drug Development, Isaiah K. Mensah, Allison B. Norvil, Ming He, Emma Lendy, Nicole Hjortland, Hern Tan, Richard T. Pomerantz, Andrew Mesecar, Humaira Gowher

Department of Biochemistry and Molecular Biology Faculty Papers

RNA methylation is a ubiquitous post-transcriptional modification found in diverse RNA classes and is a critical regulator of gene expression. In this study, we used Zika virus RNA methyltransferase (MTase) to develop a highly sensitive microplate assay that uses a biotinylated RNA substrate and radiolabeled AdoMet coenzyme. The assay is fast, highly reproducible, exhibits linear progress-curve kinetics under multiple turnover conditions, has high sensitivity in competitive inhibition assays, and significantly lower background levels compared with the currently used method. Using our newly developed microplate assay, we observed no significant difference in the catalytic constants of the full-length nonstructural protein 5 …

Poster: Moral Injury & Nurse Work Performance Following The Covid-19 Surges, Annette Callis, Trisha Saul, Ross Bindler

2023 South Division Nursing Research Conference

No abstract provided.

History And Current Status Of Mediterranean Spotted Fever (Msf) In The Crimean Peninsula And Neighboring Regions Along The Black Sea Coast, Muniver T. Gafarova, Marina E. Eremeeva

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Mediterranean spotted fever (MSF) is a tick-borne rickettsiosis caused by Rickettsia conorii subspecies conorii and transmitted to humans by Rhipicephalus sanguineus ticks. The disease was first discovered in Tunisia in 1910 and was subsequently reported from other Mediterranean countries. The first cases of MSF in the former Soviet Union were detected in 1936 on the Crimean Peninsula. This review summarizes the historic information and main features of MSF in that region and contemporary surveillance and control efforts for this rickettsiosis. Current data pertinent to the epidemiology of the disease, circulation of the ticks and distribution of animal hosts are discussed …

Nursing Leadership Panel: The Relationship Between Moral Injury, Moral Resilience, And The Healthy Work Environment Among Icu Nurses: Implications For Nurse Leaders, Sarah Sumner

2023 South Division Nursing Research Conference

No abstract provided.

Service Dogs: A Scoping Review Of Interdisciplinary Research, K. Lynn Pierce, Nancy A. Dreschel

People and Animals: The International Journal of Research and Practice

Despite a long history of service dogs (SDs) being paired with human partners as a systematic intervention and increasing numbers of and roles for SDs, there remains a lack of empirical knowledge and professional guidance regarding the implementation of SDs into treatment plans for individuals with disabilities. The purpose of this scoping review was to review the peer-reviewed literature specific to SDs and their handlers, to identify successful search term strategies, and to determine in what disciplines research is being conducted. Terminology used in referring to service dogs continues to be a challenge. Through a series of preliminary searches, search …

Anti-Inflammatory And Antioxidant Effects Of Sea Urchin Spine Extract, Dina Magdy El Gamal

The Undergraduate Research Journal

Diadema savignyi spine extract in an experimental setup using L929 cell line in vitro. The cell metabolic activity of L929 cells is tested through an MTT assay. The sea urchin spine extract is applied to the cells in two concentrations: 100 μg/ml (136% viability) and 200 μg/ml (95% viability). The bioactive components of the sea urchin spine are identified via GC-MS, and the antioxidant and anti-inflammatory activities are evaluated using catalase assay (CAT), glutathione (GSH), and nitric oxide (NO) tests. Results show that the GC-MS identified bioactive components including the anti-inflammatory and anti-irritant bisabolol oxide and the pro-inflammatory oleic acid. …

Monitoring Health Disparities In Healthcare-Associated Infection Surveillance: A Society For Healthcare Epidemiology Of America (Shea) Research Network (Srn) Survey, Caitlin L. Mcgrath, Latania K. Logan, Valerie M. Deloney, Lorry G. Rubin, Karen A. Ravin, Martha Muller, Allison H. Bartlett, Annabelle De St Maurice, W Matthew Linam, Carolyn Caughell, Lynn Ramirez-Avila, Shea Pediatric Leadership Council Steering Committee

Pediatrics Research and Scholarship

We investigated whether and how infection prevention programs monitor for health disparities as part of healthcare-associated infection (HAI) surveillance through a survey of healthcare epidemiology leaders. Most facilities are not assessing for disparities in HAI rates. Professional society and national guidance should focus on addressing this gap.

Inferior Vena Cava Thrombus Associated With Renal Cell Carcinoma With An Atypical Radiological Presentation: A Case Report, Kareem Elgendi, Mohamadhusni Zarli, Sohaib Ahmed, Nicole Szell

HPD Articles

Renal cell carcinoma (RCC) is characterized by the development of kidney masses, which can lead to various long-term complications. Among the extrarenal manifestations associated with RCC, the formation of a thrombus within the inferior vena cava (IVC) is particularly prevalent due to the substantial tumor burden imposed by the kidneys. In this report, we present an exceptional case involving an 80-year-old male patient who presented with an intravascular thrombus within the inferior vena cava (IVC), which originated from RCC. The diagnosis of RCC was conclusively established through core needle biopsy and subsequent tumor marker staining. Remarkably, despite the confirmation of …

The Effectiveness Of Disinfection Protocols In Osteopathic Family Medicine Offices, Riley Phyu, Harrison A Patrizio, Thomas Boyle, Todd Schachter

Rowan-Virtua School of Osteopathic Medicine Departmental Research

CONTEXT: Healthcare-associated infections (HAIs) pose a substantial public health threat. Despite significant strides to curb HAIs in hospital environments, outpatient settings have not received the same degree of attention. Given their emphasis on holistic, patient-centered care, osteopathic family medicine offices are pivotal in both disease prevention and comprehensive patient treatment. The importance of simple yet effective disinfection protocols, such as thorough cleaning between patient appointments, cannot be overstated in these settings because they are integral to minimizing disease transmission.

OBJECTIVES: This study aims to assess the effectiveness of the current disinfection protocols in osteopathic family medicine offices.

METHODS: A cross-sectional …