Digital Commons Network^™

Antibody Mediated Targeted Drug Delivery System To Improve Immunotherapy In Pancreatic Cancer, Poornima Devi Shaji, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan, Sheema Khan

Research Symposium

About 95% of tumor arises from epithelial cell lining ducts known to be pancreatic ductal adenocarcinomas, with less than 5-7% survival rate. Unfortunately, little progress has been seen in the outcomes of patients with PDAC as tumor develops high desmoplasia and chemo-resistance to chemotherapeutic drugs, such as gemcitabine (Gem). Immunotherapy has shown promising results in cancers, except pancreatic cancer due to their characteristic fibrotic tumor microenvironment. The therapies are unable to penetrate to the fibrotic tumors leading to insufficient availability of the therapeutic drugs at the tumor site. A recently identified mucin, MUC13 is aberrantly expressed in pancreatic tumors but …

Clinical And Social Profile Of Patients With Pulmonary Tuberculosis In Reynosa, Tamaulipas, Selena Zavala-Pérez, Erika A. Vargas-Orozco, Juan Carlos Hernandez-Martinez, José Francisco Flores-Gómez, Marisol Rosas-Diaz, Esperanza Milagros Garcia-Oropesa

Research Symposium

Background: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. It generally causes pulmonary tuberculosis, with symptoms such as fever and expectoration. In 2020, the total number of tuberculosis cases worldwide was about 9.8 million, with a mortality of 1.5 million. In Mexico, pulmonary tuberculosis represents 79% of the total cases of tuberculosis, with an incidence of 24 cases per 100,000 inhabitants. Tamaulipas ranks fifth nationally. This study seeks to determine the frequency in which social and risk factors associated with predisposition to tuberculosis occur in the population of Reynosa, Tamaulipas.

Methods: Through an observational and descriptive study, data were …

Creator Biographies, The Stimulus Team

Stimulus: A Medical Humanities Journal

No abstract provided.

New Mexico Health Care Workforce Committee 2023 Annual Report, University Of New Mexico - Health Sciences Center

New Mexico Health Care Workforce Committee (2013-ongoing)

No abstract provided.

Homoeopathic Medicines Modulate Inflammatory Functions And Adhesion Receptor Expression In Human Blood Cells: An In Vitro Study, Nibedita Dalpati, Shubham Kumar Rai, Divya Singh, Shiba Prasad Dash, Sukanti S. Sarangi, Mahabahu Nayak, Pranita P. Sarangi

Indian Journal of Research in Homoeopathy

Background: Homoeopathic medicines are used extensively for the treatment of many human diseases and are shown to affect immune cell functions. However, our understanding of the immunomodulatory effects of such medicines and associated mechanisms of action remains limited. Objectives: The present study aims to investigate the immunomodulatory effects of Arsenic album, Rhus toxicodendron, Hepar sulphuris and Bryonia alba on lipopolysaccharide (LPS) induced peripheral blood neutrophils and monocytes. Materials and Methods: In this work, neutrophils and monocytes were treated with different homoeopathic dilutions of 30C potency separately, followed by stimulation with the LPS, to examine the immunomodulatory effects of these …

Heterogenous Lung Inflammation Ct Patterns Distinguish Pneumonia And Immune Checkpoint Inhibitor Pneumonitis And Complement Blood Biomarkers In Acute Myeloid Leukemia: Proof Of Concept, Muhammad Aminu, Naval Daver, Myrna C B Godoy, Girish Shroff, Carol Wu, Luis F Torre-Sada, Alberto Goizueta, Vickie R Shannon, Saadia A Faiz, Mehmet Altan, Guillermo Garcia-Manero, Hagop Kantarjian, Farhad Ravandi-Kashani, Tapan Kadia, Marina Konopleva, Courtney Dinardo, Sherry Pierce, Aung Naing, Sang T Kim, Dimitrios P Kontoyiannis, Fareed Khawaja, Caroline Chung, Jia Wu, Ajay Sheshadri

Faculty, Staff and Student Publications

BACKGROUND: Immune checkpoint inhibitors (ICI) may cause pneumonitis, resulting in potentially fatal lung inflammation. However, distinguishing pneumonitis from pneumonia is time-consuming and challenging. To fill this gap, we build an image-based tool, and further evaluate it clinically alongside relevant blood biomarkers.

MATERIALS AND METHODS: We studied CT images from 97 patients with pneumonia and 29 patients with pneumonitis from acute myeloid leukemia treated with ICIs. We developed a CT-derived signature using a habitat imaging algorithm, whereby infected lungs are segregated into clusters ("habitats"). We validated the model and compared it with a clinical-blood model to determine whether imaging can add …

Effectiveness Of Maternal Mrna Covid-19 Vaccination During Pregnancy Against Covid-19-Associated Hospitalizations In Infants Aged <6 Months During Sars-Cov-2 Omicron Predominance - 20 States, March 9, 2022-May 31, 2023., Regina M. Simeone, Laura D. Zambrano, Natasha B. Halasa, Katherine E. Fleming-Dutra, Margaret M. Newhams, Michael J. Wu, Amber O. Orzel-Lockwood, Satoshi Kamidani, Pia S. Pannaraj, Katherine Irby, Aline B. Maddux, Charlotte V. Hobbs, Melissa A. Cameron, Julie A. Boom, Leila C. Sahni, Michele Kong, Ryan A. Nofziger, Jennifer E. Schuster, Hillary Crandall, Janet R. Hume, Mary A. Staat, Elizabeth H. Mack, Tamara T. Bradford, Sabrina M. Heidemann, Emily R. Levy, Shira J. Gertz, Samina S. Bhumbra, Tracie C. Walker, Katherine E. Bline, Kelly N. Michelson, Matt S. Zinter, Heidi R. Flori, Angela P. Campbell, Adrienne G. Randolph, Overcoming Covid-19 Investigators

Manuscripts, Articles, Book Chapters and Other Papers

Infants aged < 6 months are not eligible for COVID-19 vaccination. Vaccination during pregnancy has been associated with protection against infant COVID-19-related hospitalization. The Overcoming COVID-19 Network conducted a case-control study during March 9, 2022-May 31, 2023, to evaluate the effectiveness of maternal receipt of a COVID-19 vaccine dose (vaccine effectiveness [VE]) during pregnancy against COVID-19-related hospitalization in infants aged < 6 months and a subset of infants aged < 3 months. VE was calculated as (1 - adjusted odds ratio) x 100% among all infants aged < 6 months and < 3 months. Case-patients (infants hospitalized for COVID-19 outside of birth hospitalization and who had a positive SARS-CoV-2 test result) and control patients (infants hospitalized for COVID-19-like illness with a negative SARS-CoV-2 test result) were compared. Odds ratios were determined using multivariable logistic regression, comparing the odds of receipt of a maternal COVID-19 vaccine dose (completion of a 2-dose vaccination series or a third or higher dose) during pregnancy with maternal nonvaccination between case- and control patients. VE of maternal vaccination during pregnancy against COVID-19-related hospitalization was 35% (95% CI = 15%-51%) among infants aged < 6 months and 54% (95% CI = 32%-68%) among infants aged < 3 months. Intensive care unit admissions occurred in 23% of all case-patients, and invasive mechanical ventilation was more common among infants of unvaccinated (9%) compared with vaccinated mothers (1%) (p = 0.02). Maternal vaccination during pregnancy provides some protection against COVID-19-related hospitalizations among infants, particularly those aged < 3 months. Expectant mothers should remain current with COVID-19 vaccination to protect themselves and their infants from hospitalization and severe outcomes associated with COVID-19.

Analysis Of Resilience To Stress In Adolescents Student During The Covid-19 Pandemic, Alidina Nur Afifah, Yusri Hapsari Utami, Annisa Maimunah, Lismandasari Lismandasari, Fildzah Siti Ghassani

Media Kesehatan Masyarakat Indonesia

Stress is a condition of worry or mental tension caused by a difficult situation, often referred to as pressure. Meanwhile, resilience comprises active and distinct biological processes that protect organisms from the effects of stress. The COVID-19 pandemic has significantly impacted mental health, specifically among adolescents navigating a transitional period. Therefore, this study aimed to determine the relationship between stress and resilience among adolescents student during the COVID-19 pandemic. An analytic cross-sectional design was used and the study was conducted between February to July 2021. The subjects comprised 238 people from 22 MAN in the Jabodetabek area, selected through Cluster …

Without A Rash! A Diagnostic Dilemma For Vzv Vasculopathy, Paulina Vega Enriquez, Jose E. Campo Maldonado

Research Symposium

Varicella zoster virus vasculopathy is a condition that can classically present with a dermatomal zoster rash followed by a neurological deficit. The possible neurological manifestations and disease range are extensive. Diagnosis becomes more challenging in patients whose presentation does not include a rash, often causing cognitive errors and delay in treatment. We present a case of an 85-year-old patient, who developed stroke-like symptoms, initially with normal MRI, to later progress to multiple evolving enhancing lesions seen in subsequent MRIs. This case also represents the anchoring, that we as physicians can have when a patient with risk factors for stroke or …

Patchy Alopecia In A Young Adult With A Generalized Rash, Oscar Rodrigo Zamudio Herrera, Nevin Varghese

Research Symposium

Background: Syphilis is a sexually transmitted infection that has been increasing in the United States. The prevalence of syphilis rose by 6.8% during 2019-to 2020. Secondary syphilis typically presents with a generalized maculopapular rash on palms and soles, however, can also have subtle dermatological findings such as alopecia. Syphilitic alopecia is an atypical manifestation of secondary syphilis, seen in 2.9 to 7% of the cases.

Case presentation: An 18-year-old Hispanic male presented to the clinic after noticing patchy loss of hair on the scalp for 2 weeks and one week of generalized non pruritic rash. His past medical history was …

Culture-Negative Endocarditis Complicated With Mycotic Aneurysm And Intracranial Bleed - A Case Report, Jose A. Rivera, Daniel Aragon, Michael Menwosky, Juan Padilla

Research Symposium

Background: Blood culture-negative infective endocarditis (IE) requires at least three independent blood samples with negative cultures after seven days of incubation. Ischemic events are the most frequent neurologic complication of IE with intracranial mycotic aneurysms being the consequence of displacement of septic emboli from valvular vegetations. In this case report, we describe a young gentleman who initially presented with neurologic deficit and was later found to have mycotic aneurysms and culture negative infective endocarditis.

Case Presentation: A 34-year-old man with a past medical history of Tourette Syndrome presented to the Emergency department (ED) due to acute change in mental status. …

A Case Report Of A Primary Cerebral Abscess Due To Nocardia Asteroides In An Immunocompetent Patient, Ileana Elita Mendez, Nicole Marie Barreto, Alan Lanurias, Luis Alberto Rosas

Research Symposium

Background: Brain abscesses caused by Nocardia are rarely reported and have high mortality. It usually affects patients who are immunocompromised and initiates as a lung infection that disseminates hematogenously, though it can also affect those immunocompetent. Cerebral nocardiosis imitates brain tumors, which can delay the initiation of the appropriate antibiotic therapy.

Case Description: We present a case of a 64-year-old immunocompetent male with multiple cerebral abscesses who presented with headaches, left-sided weakness, and ataxia. Upon imaging, multiple brain lesions were revealed. The patient underwent craniotomy and drainage of the mass. He was initially empirically treated, though cultures later grew Nocardia …

Geospatial Artificial Intelligence (Geoai): Applications In Health Care, K S Sahana, C B Karthik, Mounika M Sree, M Chaithra, Stavelin K Abhinandithe, B Snehalatha, R Sridhar, S Balasubramanian, B Madhu

International Journal of Health and Allied Sciences

GeoAI is a new emerging research area that refers to set of technologies that integrate AI technology with a diversity of GIS (Geographic Information System) techniques. The present study observed that GeoAI goes beyond current GIS expectations and into the domain of possibility in the not-too-distant future. This emerging interdisciplinary science will lead us to sustainable decisions and explore the most suitable solutions to the existing problems. GeoAI has the potential to transform current geography and geomatics programs by incorporating a GeoAI dimension into modern GIS curricula. In this review, we have studied the application GeoAI in various healthcare fields. …

Long-Term Evaluation Of Clinical Success And Safety Of Omadacycline In Nontuberculous Mycobacteria Infections: A Retrospective, Multicenter Cohort Of Real-World Health Outcomes., Amer El Ghali, Taylor Morrisette, Sara Alosaimy, Kristen Lucas, Maria G Tupayachi-Ortiz, Raaga Vemula, Carly Wadle, Julie V Philley, Carlos Mejia-Chew, Yasir Hamad, Ryan W Stevens, John D Zeuli, Andrew J Webb, Christina T Fiske, Anahit Simonyan, Christo L Cimino, Mehriban Mammadova, Virginia E Umana, Rodrigo Hasbun, Saira Butt, Kyle C Molina, Michael Thomas, Emily A Kaip, Jeannette Bouchard, Tristan W Gore, Catessa Howard, M Gabriela Cabanilla, Dana J Holger, Jeremy J Frens, Melissa Barger, Aaron Ong, Keira A Cohen, Michael J Rybak

HPD Articles

Infections due to nontuberculous mycobacteria (NTM) continue to increase in prevalence, leading to problematic clinical outcomes. Omadacycline (OMC) is an aminomethylcycline antibiotic with FDA orphan drug and fast-track designations for pulmonary NTM infections, including Mycobacteroides abscessus (MAB). This multicenter retrospective study across 16 U.S. medical institutions from January 2020 to March 2023 examined the long-term clinical success, safety, and tolerability of OMC for NTM infections. The cohort included patients aged ≥18 yr, who were clinically evaluable, and` had been treated with OMC for ≥3 mo without a previous diagnosis of cystic fibrosis. The primary outcome was 3 mo clinical success, …

Japanese Legal Challenges In Rescuing Nationals Abroad, Yurika Ishii

International Law Studies

This article explains Japanese legal challenges in rescuing its nationals abroad and analyzes the mechanisms that limit Japanese Self-Defense Force responses to potential crises. The scope of analysis encompasses Japan’s national security laws, defense policies, and engagement in bilateral and multilateral cooperation. It provides noncombatant evacuation operation case studies to explore collaboration between the rescuing State, the host State, and third parties.

The article outlines Japanese laws and policies regarding the Self Defense Force’s mandate to rescue Japanese nationals abroad. It focuses on details of current legislation that provide authority and limitations for the operation. It will also track the …

Storing Eggs Safely, Christine Jensen, Charlotte P. Brennand

All Current Publications

Storing eggs safely is important for your health and that of your family. A method called "water glassing" for storing eggs was popular in the early 1900s, and some still continue using this method, but it is unsafe. This fact sheet addresses proper and safe ways to store eggs, including refrigeration, freezing, and freeze-drying.

Advances In Diagnosis And Management Of Atypical Spinal Infections: A Comprehensive Review, Glenn A. Gonzalez, Guilherme Porto, Eric Tecce, Yazan Shamli Oghli, J. Miao, Matthew O'Leary, Daniela Perez Chadid, Michael Vo, James Harrop

Department of Neurosurgery Faculty Papers

Atypical spinal infections (ASIs) of the spine are a challenging pathology to management with potentially devastating morbidity and mortality. To identify patients with atypical spinal infections, it is important to recognize the often insidious clinical and radiographic presentations, in the setting of indolent and smoldering organism growth. Trending of inflammatory markers, and culturing of organisms, is essential. Once identified, the spinal infection should be treated with antibiotics and possibly various surgical interventions including decompression and possible fusion depending on spine structural integrity and stability. Early diagnosis of ASIs and immediate treatment of debilitating conditions, such as epidural abscess, correlate with …

Cms Sepsis Bundle Compliance Analysis At The Time Of Patient Admission During The Covid-19 Pandemic In A Community Hospital In South Texas, Jose Ramos, Daniel Habenicht, Carlos Ramos

Research Symposium

Background: Sepsis remains an important cause of mortality in hospitals across the globe. The Centers for Medicare and Medicaid Services (CMS) have increased efforts to lower the mortality rate in sepsis patients via the CMS quality measure. The COVID-19 pandemic changed how we conduct healthcare and key elements of sepsis management might have been compromised, affecting the CMS sepsis bundle compliance rate. Our goals were to determine whether compliance rates were affected and to further analyze the mortality rates associated with sepsis management during the COVID-19 pandemic.

Methods: A retrospective chart review was conducted to analyze the adherence to the …

Bitten To The Bone: A Case Of Anxiety-Induced Osteomyelitis, Jose A. Rivera, Daniel Aragon, Daniela Hernandez

Research Symposium

Background: Onychophagia is a habitual nail-biting disorder, usually associated with mental or emotional diseases. It affects 20–30% of the population in all age groups. Human bites have the potential to become serious injuries due to high virulence in the human oral flora and may often require hospital admission, antibiotics and even debridement in the operating room. Thus, repetitive nail biting has the potential to be limb-threatening if not treated early and appropriately.

Case Presentation: Patient is a 49-year-old gentleman with a past medical history of severe refractory anxiety treated with hydroxyzine and scheduled alprazolam, after failing multiple other treatments, …

Patient And Provider Perceptions Of Rapid Telehealth Implementation During The Covid-19 Pandemic, Ryan G. Seibert, Amanda K. Stephenson, Aubrey K. Podell, Yuxiu K. Lei, Sheri K. Keitz

The Lahey Journal

Introduction: Despite unprecedented telehealth adoption during the COVID-19 pandemic, its post-pandemic preservation remains uncertain. Understanding key stakeholders’ perspectives on telehealth during the pandemic can inform evidence-based policies and promote effective, sustainable virtual-based care.

Methods: Patients and providers who completed telehealth visits during the early pandemic in primary care, subspecialty, and surgical outpatient clinics at a large community-based academic medical center in New England were surveyed via telephone interviews or electronic surveys. Thematic analyses of qualitative comments further characterized experiences.

Results: Of 1,729 eligible patients called, 969 were contacted and 778 participated (response rate 80.3% among contacted patients). Among 753 eligible …

Mixed Method Approach Towards The Life Of University Students During The Covid-19 Pandemic, Raihan Khan, Andrew White, Tony Jehi

Department of Health Sciences - Faculty Scholarship

Background

The COVID-19 pandemic negatively impacted the higher education system. This mixed-methods study aimed to assess COVID-19 fear, anxiety, and stress among Shenandoah Valley college students.

Methods

An online survey was fielded and completed by n=680 students. Qualitative semi-structured interviews were conducted with 20 students.

Results

The mean participant age was 22.14±5.48 years, and primarily White (81.9%), women (80.4%), and undergraduate (78.0%) students. Approximately 41% were enrolled in health-related majors (41.4%). Women students had significantly higher anxiety, depression, and fear of contracting COVID-19 than men. Undergraduate students had significantly higher depression than graduate students. Qualitative analysis revealed several major themes: …

Adjunctive Diagnostic Studies Completed Following Detection Of Candidemia In Children: Secondary Analysis Of Observed Practice From A Multicenter Cohort Study Conducted By The Pediatric Fungal Network, Rachel L Wattier, Robert F T Bucayu, Craig L K Boge, Rachael K Ross, Inci Yildirim, Theoklis E Zaoutis, Debra L Palazzi, Surabhi B Vora, Elio Castagnola, Martha Avilés-Robles, Lara Danziger-Isakov, Alison C Tribble, Tanvi S Sharma, Antonio C Arrieta, Gabriela Maron, David M Berman, Dwight E Yin, Lillian Sung, Michael Green, Emmanuel Roilides, Kiran Belani, José Romero, Pere Soler-Palacin, Eduardo López-Medina, Dawn Nolt, Ibrahim Zaid Bin Hussain, William J Muller, Sarmistha B Hauger, Natasha Halasa, Daniel Dulek, Alice Pong, Blanca E Gonzalez, Mark J Abzug, Fabianne Carlesse, Anna R Huppler, Sujatha Rajan, Catherine Aftandilian, Monica I Ardura, Arunaloke Chakrabarti, Benjamin Hanisch, Christine M Salvatore, Lena Klingspor, Elizabeth D Knackstedt, Irja Lutsar, Maria E Santolaya, Sydney Shuster, Sarah K Johnson, William J Steinbach, Brian T Fisher

Faculty, Staff and Students Publications

BACKGROUND: Adjunctive diagnostic studies (aDS) are recommended to identify occult dissemination in patients with candidemia. Patterns of evaluation with aDS across pediatric settings are unknown.

METHODS: Candidemia episodes were included in a secondary analysis of a multicenter comparative effectiveness study that prospectively enrolled participants age 120 days to 17 years with invasive candidiasis (predominantly candidemia) from 2014 to 2017. Ophthalmologic examination (OE), abdominal imaging (AbdImg), echocardiogram, neuroimaging, and lumbar puncture (LP) were performed per clinician discretion. Adjunctive diagnostic studies performance and positive results were determined per episode, within 30 days from candidemia onset. Associations of aDS performance with episode characteristics …

A Prospective Randomized Clinical Trial To Assess Antibiotic Pocket Irrigation On Tissue Expander Breast Reconstruction, Jennifer N Walker, Blake M Hanson, Tayler Hunter, Shelby R Simar, Jesus M Duran Ramirez, Chloe L P Obernuefemann, Rajiv P Parikh, Marissa M Tenenbaum, Julie A Margenthaler, Scott J Hultgren, Terence M Myckatyn

Faculty, Staff and Student Publications

Bacterial infection is the most common complication following staged post-mastectomy breast reconstruction initiated with a tissue expander (TE). to limit bacterial infection, antibiotic irrigation of the surgical site is commonly performed despite little high-quality data to support this practice. We performed a prospective randomized control trial to compare the impact of saline irrigation alone to a triple antibiotic irrigation regimen (1 g cefazolin, 80 mg gentamicin, and 50,000 units of bacitracin in 500 mL of saline) for breast implant surgery. The microbiome in breasts with cancer (

Self-Organization For Community Resilience In An Invisible Agricultural Community, Anna Erwin, Chelsea A. Silva, Zhao Ma

School of Earth, Environmental, & Marine Sciences Faculty Publications

This study investigates how self-organizing efforts by residents of informal settlements, primarily migrant and informal farmworkers, shape community resilience in Majes, a water-scarce irrigation district in the Atacama Desert of Peru. We collected 45 semi-structured interviews with residents and authorities in Majes and analyzed findings through a framework of self-organizing. Analyses revealed that self-organizing by residents of informal settlements incorporated the three components of White’s theory of Community Agency and Community Resilience, which contends that marginalized communities increase resilience by fostering a commons praxis, practicing a prefigurative politics, and developing opportunities for economic autonomy. We also found …

A Peptide-Binding Domain Shared With An Antarctic Bacterium Facilitates, Cameron J Lloyd, Shuaiqi Guo, Brett Kinrade, Hossein Zahiri, Robert Eves, Syed Khalid Ali, Fitnat Yildiz, Ilja K Voets, Peter L Davies, Karl E Klose

Faculty, Staff and Student Publications

No abstract provided.

Development And Evaluation Of Impact Statements For The Expanded Food And Nutrition Education Program (Efnep), Kylie Pybus, Ronald L. Gibbs Jr., Karen Franck, M. Catalina Aragón

Journal of Extension

Extension professionals often communicate program outcomes to external stakeholders using impact statements. We developed and evaluated four impact statements for the Expanded Food and Nutrition Education Program (EFNEP). We drafted the statements after conducting literature reviews for core content areas of EFNEP that include diet quality, food resource management, physical activity, and food safety. Subsequently, we evaluated the statements by facilitating expert panels made up of subject matter experts and communication professionals (n=14) from 12 Land-grant Universities. These impact statements aim to support EFNEP and other Extension professionals when communicating program value with key external stakeholders.

Oral Dosages Of The Nsaid Aspirin Decreased The Growth Rate Of Species Found In The Human Gut Microbiome Including Akkermansia Muciniphila, Bacteroides Fragilis, Clostridium Sordellii, And Clostridium Difficile, Wyatt H. Greenbaum, Garrett J. Greenbaum, Anna Spiezio

PANDION: The Osprey Journal of Research and Ideas

Over past few decades, new insight has been revealed in the scientific community about the importance of the human gut microbiome relating to general health. It is known that imbalances in the species that reside in the human gut can cause organism-wide problems in humans. When prescribing or injecting oral medications, the thought of the downstream effects on the gut microbiome are not always considered. By exposing known healthy members of the gut; Akkermansia muciniphila, Bacteroides fragilis, Clostridium sordellii, and Clostridium difficile to the Aspirin, this study attempted to provide insight into the effects of the drug on bacterial growth. …

Tailoring The Gut Microbiome Through Diet To Target Short Chain Fatty Acids And Trimethylamine N-Oxide For Heart Failure Prevention, Julia M. Gabel

PANDION: The Osprey Journal of Research and Ideas

The number of people diagnosed with heart failure is on the rise—it’s becoming an epidemic. There are treatment options available for heart failure, but unfortunately there is not a cure. However, most cases of heart failure can be prevented. One mechanism that provides promise for preventing heart failure is the implementation of a heart healthy diet. However, not in the context that most are familiar with. In this case, a heart healthy diet is in reference to the ability of diet to tailor the gut microbiome in order to target specific metabolites that are associated with heart failure. Diet plays …

Undernutrition In Older Children And Adolescents In Peri-Urban Zambia, Shela Sridhar, Janella S. Kang, Isabel Madzorera, Ethan Zulu, Joyce Makasa, Sally Bell Cross, Davidson H. Hamer

Department of Child, Youth, and Family Studies: Faculty Publications

Background: Adolescents make up roughly a quarter of the population in Zambia; however, most nutrition-related programming is targeted at the underfive population. Understanding the scale of undernutrition in older children and adolescents is fundamental to alleviating food insecurity and addressing undernutrition across all age groups.

Methods: A cross-sectional survey was performed in four low-income, peri-urban compounds in Chilanga District which included anthropometric measurements of children between ages 6 months-19 years and a household-level diet diversity and food security questionnaire. Wasting was used for children under 5 and thinness for children 5–19 years. Descriptive analysis and multivariate logistic regression …

Transgenic Mice Expressing Functional Tcrs Specific To Cardiac Myhc-Α 334–352 On Both Cd4 And Cd8 T Cells Are Resistant To The Development Of Myocarditis On C57bl/6 Genetic Background, Meghna Sur, Mahima T. Rasquinha, Rajkumar Arumugam, Chandirasegaran Massilamany, Arunkumar Gangaplara, Kiruthiga Mone, Ninaad Lasrado, Bharathi Yalaka, Aakash Doiphode, Channabasavaiah Gurumurthy, David J. Steffen, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

Myocarditis is a predominant cause of congestive heart failure and sudden death in children and young adolescents that can lead to dilated cardiomyopathy. Lymphocytic myocarditis mediated by T cells can result from the recognition of cardiac antigens that may involve CD4 or CD8 T cells or both. In this report, we describe the generation of T cell receptor (TCR) transgenic mice on a C57BL/6 genetic background specific to cardiac myosin heavy chain (Myhc)-α 334–352 and make the following observations: First, we verified that Myhc-α 334–352 was immunogenic in wild-type C57BL/6 mice and induced antigen-specific CD4 T cell responses despite being …