Digital Commons Network^™

Increasing Hpv Vaccination Uptake In Female College Students Aged 18-26, Gabrielle B. Scott

Doctor of Nursing Practice Scholarly Projects

Human papillomavirus (HPV) is the most common sexually transmitted infection in the world. Most people infected with HPV remain asymptomatic, but infections may result in several types of cancer. Three HPV vaccines are available with the recommended initiation of vaccination between 11–12 years, but the vaccine may be administered to females through 45 years old. Despite HPV vaccine efficacy, vaccination rates among college-age students remain low, particularly in certain geographical areas such as the Southeastern United States. This project aimed to increase HPV vaccination uptake among females between the ages of 18-26 in the Women’s Health Clinic through patient education …

Vaccine Development, The China Dilemma, And International Regulatory Challenges, Peter K. Yu

Faculty Scholarship

This article examines the role played by China in the development of international regulatory standards at the intersection of intellectual prop- erty, international trade, and public health. It begins by briefly discussing the role China has played in the global health arena during the COVID-19 pandemic. The article then highlights the difficulty in determining how best to engage with the country in the development of new international regula- tory standards. It shows that the preferred method of engagement will likely depend on one’s perspective on China’s potential contributions and hin- drances: a perspective that focuses on global competition—in the economic, …

Firearm Contagion: A New Look At History, Rachel Martin, Michael R. Ulrich

Fordham Urban Law Journal

No abstract provided.

Increasing Vaccination Rates Of 23-Valent Pneumococcal Polysaccharide Vaccine Among Patients At High-Risk For Invasive Pneumococcal Disease., Edward Lyon, Tracey Wetzel, Ann L. Wirtz, Douglas Swanson, Rachel Moran, Jessica Peters, Christine Symes, Liset Olarte, Rana El Feghaly

Posters

Introduction: Pneumococcal disease causes significant morbidity and mortality in children. Routine childhood immunizations protect for 13 or 15 pneumococcal serotypes via two pneumococcal conjugated vaccines. Patients with immunocompromising and chronic medical conditions are at high risk of invasive pneumococcal disease. A 23-valent pneumococcal polysaccharide vaccine (PPSV23) is recommended in these patients to protect against more pneumococcal serotypes, but many patients have not received it. Our AIM is to increase PPSV23 vaccination rates among eligible patients in both the inpatient and outpatient infectious diseases (ID) settings from a baseline of 44% to 55% by October 2024. Methods: In collaboration with Children’s …

Biogenic Synthesis, Spectroscopic Characterization And Bioactivity Of Cymbopogon Citratus Derived Silver Nanoparticles, Narcisse Basosila, Clément Inkoto, Ormiel Maganga, Blaise Mbembo, Giresse Kasiama, Carlos Kabengele, Clarisse Falanga, Colette Masengo, Pius Mpiana, Koto-Te-Nyiwa Ngbolua

Journal of Applied Sciences and Nanotechnology

The use of plant extracts as a bio-reducer for the synthesis of silver nanoparticles has attracted attention due to its rapid, ecological, non-toxic and economical protocol. The aim of this study was to investigate the possibility of synthesizing silver nanoparticles using Cymbopogon citratus leaf extract, and characterizing them by Ultraviolet-visible spectroscopy, X-ray Diffraction and X-ray Fluorescence in order to determine their size and composition, as well as to evaluate them in-vitro bioactivity on selected models. The results of this study show that silver nanoparticles were successfully synthesized, with a size of 29.49 nm. The silver nanoparticles showed bactericidal activity against …

Risky Business: Reopening Recreational Sport Facilities During Covid-19, Leeann M. Lower-Hoppe, Annemarie Farrell, Alina Cioletti, Ali Talcott, Mackenzie Rector, Shea M. Brgoch, Robert J. Barcelona

Journal of Applied Sport Management

At the onset of COVID-19, sport and fitness administrators shut down facilities to mitigate viral spread. To reopen facilities, safety protocols and policies reflecting risk mitigation strategies were established. This case study adopted the International Standards Organization’s risk management framework to explore strategies for reopening collegiate recreational sport facilities during the pandemic. Document analysis was employed to analyze the reopening plans of four collegiate recreation departments across North America. The reopening plans focused on the risk assessment and treatment process and used a phased approach, with strategies moving from risk avoidance to risk reduction and transfer. Common risk management strategies …

Yale Medicine Magazine Autumn 2023, Issue 171, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This is the Autumn 2023 issue of Yale Medicine Magazine, issue 171. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965) and Yale Medicine: alumni bulletin of the School of Medicine, v.1 (1965) through v. 52, no.1. (Autumn 2017).

Snapshot Of The Research Publications From The Department Of Biological Sciences, University Of Arkansas, 2019-2022, Lutishoor Salisbury, Jeremy Smith

University Libraries Faculty Publications and Presentations

This report provides a snapshot of the research publications for the Department of Biological Sciences for a four-year period.

It includes tables identifying the types of publications, the research collaboration between faculty and students (graduates and undergraduates); the JCR ranking of the journals in which they published and a listing of their publications, etc.

Candida Chorioretinitis In Immunocompromised Patient With Candida Tropicalis Fungemia Secondary To Chemotherapy, Jourdan Valkner Krause

Posters

Summary: An immunocompromised patient with candida tropicalis fungemia secondary to chemotherapy presented for follow up of candida chorioretinitis. This infection puts the patient at high risk for CNVM formation and must be followed closely. Case History: • 3-year-old Hispanic female • CC: Candida chorioretinitis follow up • POH: Bilateral orbital chloromas and optic nerve atrophy • PMH: Acute myeloid leukemia, Candida tropicalis fungemia • Meds: o Amphotericin B liposomal 85 mg 42.5 mL, IV, q24hr o Flucytosine 500 mg Capsule *NF* 1,000 mg 2 capsule, PO/NG, q6hr o Micafungin 100 mg 100 mL, IV, q24hr *Plus numerous chemotherapy, pain and …

The Role Of Cross-Reactive Immunity To Emerging Coronaviruses: Implications For Novel Universal Mucosal Vaccine Design, Wael Alturaiki

Saudi Medical Journal

Host immune response to coronaviruses and the role of cross-reactivity immunity among different coronaviruses are crucial for understanding and combating the continuing COVID-19 outbreak and potential subsequent pandemics. This review paper explores how previous exposure to common cold coronaviruses and more pathogenic coronaviruses may elicit a protective immune response against SARS-CoV-2 infection, and discusses the challenges posed by some variants of concern that may escape current vaccines. It also highlights the need for a mucosal universal vaccine that can induce long-term protection against current and emerging coronaviruses by leveraging cross-reactive immunity. We propose a novel mucosal universal vaccine that consists …

Application Of The Social Determinants Of Health To Geriatric Patients By Nurse Practitioner Students, Theresa Marie Gruenke Schnable

Dissertations (1934 -)

ABSTRACT APPLICATION OF THE SOCIAL DETERMINANTS OF HEALTH TO GERIATRIC PATIENTS BY NURSE PRACTITIONER STUDENTS Patient outcomes are influenced by the social determinants of health (SDOH), which influence differing exposures to opportunities or health risks. Holistic care of geriatric patients includes considering SDOH in patient assessment, diagnosis, and care delivery. Understanding how NP students care for geriatric patients using a SDOH lens provides insight into their practice behaviors and helps educators understand how to strengthen NP programs to achieve better patient outcomes and advance health equity for the geriatric population. The purpose of this study was to describe how NP …

Pushing Therapeutic Boundaries: Ipsc Therapy For Duchenne's Muscular Dystrophy, Long Ly

The Synapse: Intercollegiate science magazine

No abstract provided.

Issue 37

The Synapse: Intercollegiate science magazine

No abstract provided.

Limited Accumulation And Persistence Of An Influenza A Virus In Tadpole Snails (Physa Spp.), Paul T. Oesterle, J. Jeffrey Root, Darcy S.O. Mora, Heather Schneider, Alan B. Franklin, Kathryn P. Huyvaert

United States Department of Agriculture Wildlife Services: Staff Publications

Waterfowl infected with avian influenza A viruses (IAVs) shed infectious virus into aquatic environments, providing a mechanism for transmission among waterfowl, while also exposing the entire aquatic ecosystem to the virus. Aquatic invertebrates such as freshwater snails are likely exposed to IAVs in the water column and sediment. Freshwater snails comprise a significant portion of some waterfowl species’ diets, so this trophic interaction may serve as a novel route of IAV transmission. In these experiments, tadpole snails (Physa spp.) were exposed to a low-pathogenicity IAV (H3N8) to determine whether snails can accumulate the virus and, if so, how long virus …

Editorial: Current Advances In Anti-Infective Strategies, Asmaa M. Salih Almohaidi, Fikrat M. Hassan, Hussin Rothan

Baghdad Science Journal

Infectious diseases pose a global challenge, necessitating an exploration of novel methodologies for diagnostics and treatments. Since the onset of the most recent pandemic, COVID-19, which was initially identified as a worldwide health crisis, numerous countries experienced profound disruptions in their healthcare systems. To combat the spread of the COVID-19 pandemic, governments across the globe have mobilized significant efforts and resources to develop treatments and vaccines. Researchers have put forth a multitude of approaches for COVID-19 detection, treatment protocols, and vaccine development, including groundbreaking mRNA technology, among others. This matter represents not only a scientific endeavor but also an essential …

Evaluation Of The Cytotoxic Effects Of The Colchicine Compound Isolated From The Leaves Of Calotropis Procera (Ait) Against Mcf-7 And Sk-Gt-4 Cancer Cell Lines., Muna A.Y. Al-Mussawii, Emad Y. A. Al-Sultan, Maytham A. Al-Hamdani

Baghdad Science Journal

Alkaloids are regarded as important nitrogen-containing chemical compounds that serve as a rich source for discovering and developing new drugs where most plant-origin alkaloids have antiproliferation effects on different kinds of cancers. Alkaloids’ continence of Calotropis procera leaves are detected by two biochemical alkaloid reagents. Also GC-MS analysis for leaf alkaloid extract was done that showed the existence of one type of alkaloid compound at retention time12.8min detected as colchicine (C22H25N06( by comparing it with colchicine standard reference (Sigma Aldrich) with M.wt 399g/mol and percentage area 7.1%. Furthermore, identification, separation, and purification for purified colchicine compound were conducted by HPLC …

Dense Granule Protein 3 Of Toxoplasma Gondii Plays A Crucial Role In The Capability Of The Tissue Cysts Of The Parasite To Persist In The Presence Of Anti-Cyst Cd8+ T Cells During The Chronic Stage Of Infection, Rajesh Mani, Mohamed H. Abdelaziz, Eri Ochiai, Qila Sa, Barbara A. Fox, David J. Bzik, Yasuhiro Suzuki

Markey Cancer Center Faculty Publications

Toxoplasma gondii establishes chronic infection by forming tissue cysts, and this chronic infection is one of the most common parasitic infections in humans. Our recent studies revealed that whereas CD8 + T cells of genetically resistant BALB/c mice have the capability to remove the tissue cysts of the parasite through their perforin-mediated activities, small portions of the cysts are capable of persisting in the presence of the anti-cyst CD8+ T cells. It is currently unknown how those small portions of the cysts resist or escape the T-cell immunity and persist in the hosts. In the present study, we discovered that …

Inhibition Of Mitochondrial Fission Activates Glycogen Synthesis To Support Cell Survival In Colon Cancer, Sumati Raj Hasani, Lyndsay E. A. Young, Warren Van Nort, Moumita Banerjee, Dylan R. Rivas, Jinhwan Kim, Xiaopeng Xiong, Ramon C. Sun, Matthew S. Gentry, Hiromi Sesaki, Tianyan Gao

Markey Cancer Center Faculty Publications

Metabolic reprogramming has been recognized as one of the major mechanisms that fuel tumor initiation and progression. Our previous studies demonstrate that activation of Drp1 promotes fatty acid oxidation and downstream Wnt signaling. Here we investigate the role of Drp1 in regulating glycogen metabolism in colon cancer. Knockdown of Drp1 decreases mitochondrial respiration without increasing glycolysis. Analysis of cellular metabolites reveals that the levels of glucose-6-phosphate, a precursor for glycogenesis, are significantly elevated whereas pyruvate and other TCA cycle metabolites remain unchanged in Drp1 knockdown cells. Additionally, silencing Drp1 activates AMPK to stimulate the expression glycogen synthase 1 (GYS1) mRNA …

Application Of Computational Tools To Identify Variations Associated With Peromyscus Dominant Spot, Zhenhua Shang

Theses and Dissertations

Peromyscus are the most prevalent mammalian species in North America, and they're employed extensively in both laboratory and field studies. P. maniculatus and P. polionotus, the deer mouse and the old-field mouse, are closely related and can produce viable and fertile hybrid offspring. However, a comprehensive database of polymorphisms, particularly in those kept as living stocks and supplied to university researchers, is lacking. In chapter 2, we performed comparative genomic study on P. maniculatus and P. polionotus and used the polymorphic data to identify the range of genetic complexity that underlies physiological and behavioral differences between two species. We also …

The Intersectionality Of Rurality And Race On Covid-19 Vaccination Among Adults In The United States, Shiba Simon Bailey

Theses and Dissertations

Background Vaccination remains a cornerstone of public health, significantly contributing to the prevention and control of infectious diseases. During the COVID-19 pandemic, vaccine development was critical to prevent new SARS-Cov-2 infections. However, COVID-19 vaccination uptake among racial and ethnic minority populations and rural residents in the United States (US) lags behind their urban non-Hispanic White counterparts. Underlying causes of these disparities are unclear, but vaccine hesitancy, access to care barriers, and structural racism may be to blame. Such barriers may vary by residential urbanicity, leading to different racial/ethnic disparities in rural and urban America. Understanding the variations in vaccine uptake …

Outcome And Complications Of Outpatient Parenteral Therapy In Pediatric Emergency Utilizing Only Peripheral Vascular Access: A Retrospective Descriptive Study, Nasser A. Haidar, Mohammed N. Alamri, Fysel L. Manthattil, Mohammed A. Alshaof, Sharaf M. Alkuhali

Saudi Medical Journal

Objectives: To describe the cure and complication rates of outpatient parenteral therapy (OPT) utilizing only peripheral vascular access. Methods: Using a retrospective descriptive study design, we reviewed the medical charts for children aged up to 15 years old who had been discharged from the emergency department into the care of the OPT unit from January 2018 to April 2019. The primary outcomes were cure and complication rates. Results: Out of 814,150 visits, 2,788 (0.34%), accounting for 2,126 patients, were managed in the OPT unit. The majority had 2 days of symptoms, and 26.4% had comorbidities. Most patients started the treatment …

H5n1 Highly Pathogenic Avian Influenza Clade 2.3.4.4b In Wild And Domestic Birds: Introductions Into The United States And Reassortments, December 2021–April 2022, Sungsu Youk, Mia Kim Torchetti, Kristina Lantz, Julianna B. Lenoch, Mary Lea Killian, Christina Leyson, Sarah N. Bevins, Krista Dilione, Hon S. Ip, David E. Stallknecht, Rebecca L. Poulson, David L. Suarez, David E. Swayne, Mary J. Pantin-Jackwood

United States Department of Agriculture Wildlife Services: Staff Publications

Highly pathogenic avian influenza viruses (HPAIVs) of the A/goose/Guangdong/1/1996 lineage H5 clade 2.3.4.4b continue to have a devastating effect on domestic and wild birds. Full genome sequence analyses using 1369 H5N1 HPAIVs detected in the United States (U.S.) in wild birds, commercial poultry, and backyard flocks from December 2021 to April 2022, showed three phylogenetically distinct H5N1 virus introductions in the U.S. by wild birds. Unreassorted Eurasian genotypes A1 and A2 entered the Northeast Atlantic states, whereas a genetically distinct A3 genotype was detected in Alaska. The A1 genotype spread westward via wild bird migration and reassorted with North American …

October 2023 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Reducing The Rate Of Central Line-Associated Bloodstream Infections; A Quality Improvement Project, David Odada, Hellen Munyi, Japhet Gatuiku, Ruth Thuku, Jared Nyandigisi, Anne Wangui, Emilie Ashihundu, Beatrice Nyakiringa, Jemimah Kimeu, Martin Musumbi, Rodney Adam

Internal Medicine, East Africa

Background The burden of central line-associated bloodstream infections is significant and has negative implications for healthcare, increasing morbidity and mortality risks, increasing inpatient hospital stays, and increasing the cost of hospitalization. Efforts to reduce the incidence of central line-associated bloodstream infections have utilized quality improvement projects that implement, measure, and monitor outcomes. However, variations in location, healthcare organization, patient risks, and practice gaps are key to the success of interventions and approaches. This study aims to evaluate interventions of a quality improvement project on the reduction of central line-associated bloodstream infection rates at a university teaching hospital.

Methods This was …

Universal Health Coverage: A Basis For Pandemic Preparedness?, Merline Feero

Independent Study Project (ISP) Collection

Amid extensive research and reporting on the effects of COVID-19 on Universal Health Coverage (UHC) progress, this study explores an often neglected topic: the potential of UHC to contribute to the foundations of pandemic preparedness. Herein, quantitative analysis reveals that countries with higher UHC coverage tend to exhibit greater pandemic preparedness (as determined by the UHC Service Coverage Index and the Global Health Security Index). Complementary qualitative analysis is used to further illustrate and explain the correlation between UHC and pandemic preparedness using four case study countries, integrating literature reviews and relevant expert interviews. Through these methods, a clear tie …

Biopsychosocial Resilience Through A Complex Adaptive Systems Lens: A Narrative Review Of Nonlinear Modeling Approaches, Adam W. Kiefer, David Pincus

Psychology Faculty Articles and Research

Human resilience is often considered as static traits using a reductionist approach. More recent work has demonstrated it to be a dynamic and emergent property of complex systems. This narrative review explores human resilience through a self-organizing framework with a specific emphasis on the application of nonlinear modeling approaches. Four classes of approaches are examined: univariate dynamics, bivariate coupling, topological modeling, and network modeling. Univariate dynamics capture the temporal structure and flexibility within a single time series, while bivariate coupling approaches quantify the interaction dynamics and coordination between two time series. Topological modeling identifies bifurcations and attractor dynamics as signals …

Incidence And Risk Factors Associated With Febrile Neutropenia In Acute Myeloid Leukemia Patients During Induction Phase, Thitichaya Penthinapong, Adisak Tantiworawit, Donlaya Trakoonchai, Tanatchaporn Sornsong, Jukapun Yoodee

The Thai Journal of Pharmaceutical Sciences

Background: Acute myeloid leukemia (AML) with febrile neutropenia (FN) had a higher incidence among hematologic malignancies. The varied incidence and risk factors predictive of FN among patients with AML were reported. Hence, this study aimed to evaluate the incidence and risk factors associated with FN in AML patients who underwent the induction phase of chemotherapy. Material and Methods: In this retrospective cohort study, patients who were newly diagnosed with AML and receiving the induction phase of the idarubicin/cytarabine 3+7 regimen or 2+5 were included between January 2008 and December 2021. The primary outcome was an incidence of FN. …

A Validated Stability-Indicating High-Performance Liquid Chromatography-Photodiode Array Method For The Evaluation Of Extemporaneous Compounded Formulations Prepared From Isoniazid Substances And Tablets, Sudaporn Wongwan, Nithima Kharomprat, Suporn Charumanee, Nantaka Khorana

The Thai Journal of Pharmaceutical Sciences

Objectives: The objectives of the study are to develop and validate a stability-indicating method for evaluating the stability of extemporaneous oral liquid formulations containing 50 mg/mL isoniazid (INH) prepared from INH drug substances and INH tablets. Materials and Methods: The optimized high-performance liquid chromatography (HPLC) conditions included a C18 column (250 mm × 4.6 mm, 5 μm), a flow rate of 1 mL/min, a column temperature of 30°C, and a detection wavelength of 254 nm. The separations were performed using a gradient HPLC system, employing acetonitrile and water as the mobile phases. The method was validated according to …

The Implications Of Politicizing Global Health Diplomacy In A Multipolar World, Haley Stock

Independent Study Project (ISP) Collection

This research paper is the result of an independent study project that details the implications of politicizing global health diplomacy. With a mixture of interviews, primary sources, and secondary sources, this project aims to explain how and why global health has become entrenched in politics in the world today. This paper explores the intersection between global health and foreign policy and analyzes the extent to which countries use medical interventions to achieve political and economic success. Medical interventions, like vaccines, have become increasingly significant, especially looking back at the recent pandemic. Therefore, this paper will also explore the complex nature …

Revised Draft Final Quarterly Operations And Maintenance Report Butte Treatment Lagoon System – First Quarter 2022, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.