Digital Commons Network^™

Dna Methylation And The Response To Infection In Introduced House Sparrows, Melanie Gibson

College of Graduate Studies: Theses & Dissertations

Epigenetics is the study of molecular modification of a genome without changing its base pairs. The most studied type of epigenetic mechanism is DNA methylation, which is capable of turning a gene “on” or “off.” Epigenetic potential is the capacity to which an individual can have methylation on its genome. The more CpGs available, the greater the epigenetic potential. In invasive species, genetic variation has been observed to be paradoxical: not much of it exists on a genomic level, but epigenetically, phenotypic variation can occur. The focus on shift in gene expression in this study is on Toll-Like Receptor 4 …

Jiann-Ping Hsu College Of Public Health Magazine, Georgia Southern University

College of Public Health: News & Publications

• Message from the Dean: Stuart H. Tedders, PhD
• Remembering Dr. Evans Afriyie-Gyawu
• Exploring Research Focus Areas
• Alumni Feature: Overcoming Hurdles
• Research Feature: It's a weighted issue.
• Research Feature: The effectiveness of lactation cookies
• Period Equity Movement Earns National Recognition
• Leaving Her Mark
• Georgia on Our Mind
• Center for Addiction Recovery: Transforming Lives through Comprehensive Support
• Center for Public Health Practice and Research: The LEAD Academy: A Hospital Leadership Training Program
• Office of Practice and Research: Continued Engagement in Practice and Research
• Office of Teaching and Learning
• Office of Health Equity and Community: Engagement Continued Engagement in Practice and Research
• Awards, …

Utilizing Wearable Technology To Characterize And Facilitate Occupant Collaborations In Flexible Workspaces, Kristi Maisha, Mario Frei, Matias Quintana, Xuan Yun Chua, Rishee Jain, Clayton Miller

Research Collection College of Integrative Studies

Hybrid working strategies have become, and will continue to be, the norm for many offices. This raises two considerations: newly unoccupied spaces needlessly consume energy, and the occupied spaces need to be effectively used to facilitate meaningful interactions and create a positive, sustainable work culture. This work aims to determine when spontaneous, collaborative interactions occur within the building and the environmental factors that facilitate such interactions. This study uses smartwatch-based micro-surveys using the Cozie platform to identify the occurrence of and spatially place interactions while categorizing them as a collaboration or distraction. This method uniquely circumvents pitfalls associated with surveying …

Improving Cervical Cancer Screening In Sub-Saharan Africa, Nigeria: Reaching Levels Of Cervical Cancer Prevention In Developed Countries, Chigozie Alexandra Ogwara, Biyi-Olutunde Olusegun, Yelena Tarasenko

Eagles Talking About the Public’s Health

No abstract provided.

An Analysis Of A Public Health Media Campaign In Switzerland, Eleanor Saskia Faulk-Antonakis

Plymouth Business School Theses

This multidisciplinary, grounded theory study analyses public health media communication for Human Immunodeficiency Virus (HIV) and Sexually Transmitted Infections (STI) prevention in Switzerland. Health communication researchers measure the effects of media campaigns on populations to improve prevention. However, such effects may evade measurement due to complex interactions between audiences, media channels and ecology, message content, and targeting strategies. Competing theories explain media effects on health behaviours but there is a dearth of research examining upstream planning and stakeholder perceptions of media campaigns. In effect, interactions between communities, health officials, practitioners, and communication/media stakeholders are politically sensitive, and inaccessible to researchers. …

Sars-Cov-2 Main Protease Targeting Potent Fluorescent Inhibitors: Repurposing Thioxanthones, Gönül Saadet Batibay, Eyüp Meti̇n

Turkish Journal of Chemistry

The coronavirus disease, COVID-19, is the major focus of the whole world due to insufficient treatment options. It has spread all around the world and is responsible for the death of numerous human beings. The future consequences for the disease survivors are still unknown. Hence, all contributions to understand the disease and effectively inhibit the effects of the disease have great importance. In this study, different thioxanthone based molecules, which are known to be fluorescent compounds, were selectively chosen to study if they can inhibit the main protease of SARS-CoV-2 using various computational tools. All candidate ligands were optimized, molecular …

Autologous T Cell Therapy For Mage-A4+ Solid Cancers In Hla-A*02+ Patients: A Phase 1 Trial, David S Hong, Brian A Van Tine, Swethajit Biswas, Cheryl Mcalpine, Melissa L Johnson, Anthony J Olszanski, Jeffrey M Clarke, Dejka Araujo, George R Blumenschein, Partow Kebriaei, Quan Lin, Alex J Tipping, Joseph P Sanderson, Ruoxi Wang, Trupti Trivedi, Thejo Annareddy, Jane Bai, Stavros Rafail, Amy Sun, Lilliam Fernandes, Jean-Marc Navenot, Frederic D Bushman, John K Everett, Derin Karadeniz, Robyn Broad, Martin Isabelle, Revashnee Naidoo, Natalie Bath, Gareth Betts, Zohar Wolchinsky, Dzmitry G Batrakou, Erin Van Winkle, Erica Elefant, Armin Ghobadi, Amanda Cashen, Anne Grand'maison, Philip Mccarthy, Paula M Fracasso, Elliot Norry, Dennis Williams, Mihaela Druta, David A Liebner, Kunle Odunsi, Marcus O Butler

Faculty, Staff and Student Publications

Affinity-optimized T cell receptors can enhance the potency of adoptive T cell therapy. Afamitresgene autoleucel (afami-cel) is a human leukocyte antigen-restricted autologous T cell therapy targeting melanoma-associated antigen A4 (MAGE-A4), a cancer/testis antigen expressed at varying levels in multiple solid tumors. We conducted a multicenter, dose-escalation, phase 1 trial in patients with relapsed/refractory metastatic solid tumors expressing MAGE-A4, including synovial sarcoma (SS), ovarian cancer and head and neck cancer ( NCT03132922 ). The primary endpoint was safety, and the secondary efficacy endpoints included overall response rate (ORR) and duration of response. All patients (N = 38, nine tumor types) experienced …

Comparison Of Permafrost Thaw-Related Changes To Hydrological Response And Land Cover In Subarctic Peatland-Dominated Landscapes, Mikhail Mack

Theses and Dissertations (Comprehensive)

The hydrological implications of discontinuous permafrost thaw in peatland-dominated basins are not well understood. While there is evidence suggesting that permafrost-thaw-driven land cover change increases annual runoff and the runoff ratio in the Taiga Plains of northwestern Canada, few studies have evaluated the impact on small to medium-sized basins (< 10⁵ km²) outside this ecoregion. Here, we assess runoff, runoff ratio, and precipitation trends for 34 peatland-dominated basins, of which 28 are in the discontinuous and sporadic permafrost zones and 6 in adjacent permafrost-free environments. We calculated annual and monthly trends between 1970 and 2016 using the Mann-Kendall …

Lived Experiences Of American Adults Who Survive Covid-19: Implications For Physical Activity And Interpersonal Stress, Linda B. Piacentine, Hannah C. Barbosa, Kristin Haglund, Lauren Opielinski, Sandra K. Hunter, Paula E. Papanek, Marie K. Hoeger Bement, Norah L. Johnson

College of Nursing Faculty Research and Publications

Introduction: The cumulative number of COVID-19 cases has surpassed 579 million globally. Symptoms during and after COVID-19 infection vary from mild cold symptoms to severe multisystem illness. Given the wide range of symptom presentations and complications post COVID-19, the purpose of this study was to describe the lived experience of American adults surviving COVID-19.

Method: This study employed an exploratory qualitative description design. Semi-structured interviews were conducted with a sample of 35 individuals, [white (94%), female (71%), mean age = 43.7 years], with proximity to a university in an urban Midwest American city. Interviews occurred between May and …

Predictors Of Nonadherence Among Patients With Infectious Complications Of Substance Use Who Are Discharged On Parenteral Antimicrobial Therapy, Shivakumar Narayanan, Patrick R Ching, Edward C Traver, Nivya George, Anthony Amoroso, Shyam Kottilil

2020-Current year OA Pubs

BACKGROUND: The management of invasive infections related to substance use disorder (SUD) needing parenteral antimicrobial therapy is challenging and may have poor treatment outcomes including nonadherence and lack of completion of parenteral antimicrobial therapy.

METHODS: In this retrospective cohort of 201 patients with invasive infections related to SUD, we looked at frequency and determinants of unfavorable outcomes including nonadherence.

RESULTS: Seventy-nine percent of patients with SUD-related infection completed parenteral antibiotic therapy in skilled nursing facilities. A total of 21.5% of patient episodes had documentation of nonadherence. Nonadherence was higher in patients with active injection drug use (IDU) (28.5% versus 15% …

Enhancing The Therapeutic Activity Of Hyperimmune Igg Against Chikungunya Virus Using Fcγriiia Affinity Chromatography, Julie M Fox, Vicky Roy, Bronwyn M Gunn, Glen R Bolton, Daved H Fremont, Galit Alter, Michael S Diamond, Austin W Boesch

2020-Current year OA Pubs

INTRODUCTION: Chikungunya virus (CHIKV) is a re-emerging mosquito transmitted alphavirus of global concern. Neutralizing antibodies and antibody Fc-effector functions have been shown to reduce CHIKV disease and infection in animals. However, the ability to improve the therapeutic activity of CHIKV-specific polyclonal IgG by enhancing Fc-effector functions through modulation of IgG subclass and glycoforms remains unknown. Here, we evaluated the protective efficacy of CHIKV-immune IgG enriched for binding to Fc-gamma receptor IIIa (FcγRIIIa) to select for IgG with enhanced Fc effector functions.

METHODS: Total IgG was isolated from CHIKV-immune convalescent donors with and without additional purification by FcγRIIIa affinity chromatography. The …

Public Attitudes Towards Non-Criminal Preventive Detention As A Function Of The Covid-19 Pandemic, Matt Zaitchik, Kyle Gamache, Judith Platania

Arts & Sciences Faculty Publications

Non-criminal preventive detention is justified by both the state’s parens patriae and police power roles. Individuals with mental illness and individuals with a highly communicable, potentially lethal disease can be involuntarily detained. Modern applications of quarantine have led to higher court decisions that address the balance between liberty and public health and safety. The inherent tensions that underlie quarantine law – individual liberty versus public safety – are apparent in our contemporary, COVID-19 America. Consequently, much of the current discussion appears to have political overtones. In order to empirically address this issue, in the current study we examine attitudes towards …

A Student-Designed Multimodal Sex- And Gender-Based Women's Health Elective Program: Advocacy Curriculum For Medical Students, Lauren M Conroy, Danna Ghafir, Maitreyi Narayan, Hunter Mcspedden, Samuel Neher, S Shahrukh Hashmi, Rebecca Lunstroth

Faculty, Staff and Student Publications

OBJECTIVES: The objective of this article is to describe the design and implementation of a multimodal, student-driven, sex- and gender-based women's health (SGBWH) elective with a curricular focus on patient and legislative advocacy. In this single arm, pre/post design, interventional study, we detail and evaluate the use of social media, newsletters, and round-table discussions in conjunction with a traditional lecture-based educational format to engage medical students in a virtual learning environment.

METHODS: We developed a 22-week SGBWH curriculum for pre-clinical and clinical medical students, which included a series of lectures on multi-specialty and gender-inclusive topics related to SGBWH, small group …

Targeting Immunosuppressive Ly6c+ Classical Monocytes Reverses Anti-Pd-1/Ctla-4 Immunotherapy Resistance, B Leticia Rodriguez, Limo Chen, Yanli Li, Shucheng Miao, David H Peng, Jared J Fradette, Lixia Diao, Jessica M Konen, Frank R Rojas Alvarez, Luisa M Solis, Xiaohui Yi, Aparna Padhye, Laura A Gibson, Joshua K Ochieng, Xiaofei Zhou, Jing Wang, Don L Gibbons

Faculty, Staff and Student Publications

Introduction: Despite significant clinical advancement with the use of immune checkpoint blockade (ICB) in non-small cell lung cancer (NSCLC) there are still a major subset of patients that develop adaptive/acquired resistance. Understanding resistance mechanisms to ICB is critical to developing new therapeutic strategies and improving patient survival. The dynamic nature of the tumor microenvironment and the mutational load driving tumor immunogenicity limit the efficacy to ICB. Recent studies indicate that myeloid cells are drivers of ICB resistance. In this study we sought to understand which immune cells were contributing to resistance and if we could modify them in a way …

Silver(I) 1,10-Phenanthroline Complexes Are Active Against Fonsecaea Pedrosoi Viability And Negatively Modulate Its Potential Virulence Attributes, Ingrid S. Sousa Ingrid S. Sousa, Tatiana D.P. Vieira, Rubem F. S. Menna-Barreto, Allan J. Guimarães, Pauraic Mccarron, Malachy Mccann, Michael Devereux, André L. S. Santos, Lucimar F. Kneipp

Articles

The genus Fonsecaea is one of the etiological agents of chromoblastomycosis (CBM), a chronic subcutaneous disease that is difficult to treat. This work aimed to evaluate the effects of copper(II), manganese(II) and silver(I) complexes coordinated with 1,10-phenanthroline (phen)/1,10- phenanthroline-5,6-dione (phendione) on Fonsecaea spp. Our results revealed that most of these complexes were able to inhibit F. pedrosoi, F. monophora and F. nubica conidial viability with minimum inhibitory concentration (MIC) values ranging from 0.6 to 100 M. The most effective complexes against F. pedrosoi planktonic conidial cells, the main etiologic agent of CBM, were [Ag(phen)2]ClO4 and [Ag2(3,6,9-tdda)(phen)4].EtOH, (tdda: 3,6,9-trioxaundecanedioate), displaying MIC …

Silver(I) And Copper(Ii) 1,10-Phenanthroline-5,6-Dione Complexes As Promising Antivirulence Strategy Against Leishmania: Focus On Gp63 (Leishmanolysin), Simone S.C. Oliveira, Claudyane A. Correia, Vanessa S. Santos, Elaine F.F. Da Cunha, Alexandre A. De Castro, Teodorico C. Ramalho, Michael Devereux, Malachy Mccann, Marta H. Branquinha, Andre L.S. Santos

Articles

Leishmaniasis, caused by protozoa of the genus Leishmania, encompasses a group of neglected diseases with diverse clinical and epidemiological manifestations that can be fatal if not adequately and promptly managed/treated. The current chemotherapy options for this disease are expensive, require invasive administration and often lead to severe side effects. In this regard, our research group has previously reported the potent anti-Leishmania activity of two coordination compounds (complexes) derived from 1,10-phenanthroline-5,6-dione (phendione): [Cu(phendione)3 ].(ClO4 )2 .4H2O and [Ag(phendione)2 ].ClO4 . The present study aimed to evaluate the effects of these complexes on leishmanolysin (gp63), a virulence factor produced by all Leishmania …

Peptidases Are Potential Targets Of Copper(Ii)-1,10-Phenanthroline-5,6-Dione Complex, A Promising And Potent New Drug Against Trichomonas Vaginalis, Graziela Vargas Rigo, Fernanda Gomes Cardoso, Matheus Mendonca Pereira, Michael Devereux, Malachy Mccann, Andre L.S. Santos, Tiana Tasca

Articles

Trichomonas vaginalis is responsible for 156 million new cases per year worldwide. When present asymptomatically, the parasite can lead to serious complications, such as development of cervical and prostate cancer. As infection increases the acquisition and transmission of HIV, the control of trichomoniasis represents an important niche for the discovery and development of new antiparasitic molecules. This urogenital parasite synthesizes several molecules that allow the establishment and pathogenesis of infection. Among them, peptidases occupy key roles as virulence factors, and the inhibition of these enzymes has become an important mechanism for modulating pathogenesis. Based on these premises, our group recently …

Parents' Experiences Of Infant And Young Child Feeding During The Covid-19 Pandemic In Ireland, Elizabeth J. O'Sullivan, Aileen Kennedy

Articles

Objective: The WHO has urged member states to develop preparedness plans for infant and young child feeding (IYCF) during emergencies. Ireland has no such plan. We aimed to identify the needs of caregivers in Ireland with regards IYCF during the COVID-19 pandemic. Design: Online survey conducted in May-June 2020. Setting: Ireland, during the first period of severely restricted movement due to COVID-19 (lockdown). Participants: Respondents (n 745) were primary caregivers of a child under 2 years; they were primarily well educated and likely of higher socio-economic status. Results: Among those who breastfed, being unable to access breast-feeding support groups and …

A Randomized Controlled Trial Of An Oral Probiotic To Reduce Antepartum Group B Streptococcus Colonization And Gastrointestinal Symptoms, Lisa Hanson, Leona Vandevusse, Marie Forgie, Emily Malloy, Maharaj Singh, Maryanne Scherer, Diana Kleber, Jonah Dixon, Andrew J. Hryckowian, Nasia Safdar

College of Nursing Faculty Research and Publications

BACKGROUND

Probiotics have been suggested as a strategy to reduce antenatal group B Streptococcus colonization. Although probiotics are known to improve gastrointestinal symptoms, this has not been studied during pregnancy.

OBJECTIVE

This study aimed to evaluate the efficacy of a probiotic to reduce: (1) standard-of-care antenatal group B Streptococcus colonization and colony counts and (2) gastrointestinal symptoms of pregnancy.

STUDY DESIGN

In a double-blind fashion, 109 healthy adult pregnant people were randomized to Florajen3 probiotic or placebo capsules once daily from 28 weeks’ gestation until labor onset. Baseline vaginal and rectal study swabs for group B Streptococcus colony-forming units and …

The Monroe Method: A Methodology On Navigating Race, Oppression, And Equity In Medical Education Through Physician Cultural Responsibility, Christen D. Johnson

Antioch University Dissertations & Theses

Many forms of oppression create barriers for health care, further health disparities, and impact the wellness of physicians. As health disparities, caused by the social determinants of health, complicate the practice of medicine, physicians’ risk of burnout increases. The practice of Physician Cultural Responsibility provides a means to overcome health disparities and support physicians while embracing the intersectionality of the populations they serve. Incorporation of Physician Cultural Responsibility into physician professional identity is essential for the practice to be life-long. As there is no standardized curriculum to address teaching the practice of Physician Cultural Responsibility, this study aims to evaluate …

Clinical Manifestations And Outcome Of Patients With Primary Amoebic Meningoencephalitis In Pakistan A Single-Center Experience, Shakeel Ur Rehman, Salman Farooq, Muhammad Bilal Tariq, Nosheen Nasir, Mohammad Wasay, Sobia Masood, Musa Karim

Faculty, Staff and Student Publications

Primary amoebic meningoencephalitis (PAM) is a rapidly progressing central nervous system (CNS) infection caused by Naegleria fowleri, a free-living amoeba found in warm freshwater. The disease progression is very rapid, and the outcome is nearly always fatal. We aim to describe the disease course in patients admitted with PAM in a tertiary care center in Karachi, Pakistan between the periods of 2010 to 2021. A total of 39 patients were included in the study, 33 males (84.6%). The median age of the patients was 34 years. The most frequent presenting complaint was fever, which was found in 37 patients (94.9%) …

Perceptions Of Florida Victim Advocates During The Covid-19 Pandemic, Katarina Renee Hamburg

Theses and Dissertations

In December of 2019, a new virus known as COVID-19 emerged out of Wuhan, China. COVID-19 is a respiratory virus which is highly contagious and, in some cases, lethal. By January 20th, 2020, the United States reported its first case of COVID-19. Between January and December of 2020 there were 18.7 million cases and 329,000 deaths in the United States alone. Globally, during that time frame, there were 79.8 million cases and 1.75 million deaths. Due to the highly contagious and dangerous nature of COVID-19, countries across the world have attempted to promote public health by enacting social distancing measures. …

Human Trafficking: The Impact Of Covid-19 On Labor Trafficking In The Us, Anthony A. Mottola

Theses and Dissertations

Human trafficking is a global phenomenon where traffickers prey upon their victims without discriminating against age, gender, ethnic background, or nationality. The United States (US) is not immune to the human rights violations of human trafficking. The victims of human trafficking are coerced into a life of exploitation through forced labor or sexual exploitation. Many victims are migrants from disadvantaged countries that travel to the US seeking employment but end up the victims of abuse, both physically and mentally, at the hands of traffickers. In 2020, the COVID-19 pandemic devastated the global economy, forcing quarantines, travel bans, and social distancing. …

A Mixed-Method Study On Social Media’S Role In The Health Decision-Making Practices Of Black Millennial Women In South Florida, Sashah Damier

Theses and Dissertations

The purpose of this research study was to examine health care decision-making practices of Black millennial women in South Florida, based on their social media use. The study contributed to understanding of how cultural components contribute to health care disparities for people of color because health care providers lacked information on how to reach Black millennial women with accurate and helpful information through social media.

The design for the study included a convergent parallel mixed-methods design using a web-based quantitative cross-sectional survey along with embedded qualitative telephone interviews and NVivo software. This mixed-methods methodology provided rich data and new understandings …

Teachers’ Experiences In Implementing Primary School Physical Education Curriculum In Ghana And The United States, Patrick Collins Frempong

Theses and Dissertations

Barriers to implementing a full physical education curriculum presented challenges to teaching students about healthy lifestyles and supporting them through effective lessons. This mixed-methods study aimed to explore and compare primary school teachers’ experiences in rural Ghana and the United States in implementing the physical education curriculum. The present study addresses gaps in the literature by connecting teacher concerns when implementing a curriculum with fidelity. The mixed-methods study helped explore and compare primary school teachers’ experiences in rural (town populations of less than 5,000) Ghana and rural towns of the southern United States in implementing the physical education curriculum.

This …

We Can Do This / Juntos Sí Podemos: A Critical Discourse Analysis Of Government-Sponsored Covid-19 Public Service Announcements (Psas) In English And Spanish, Katalina R. Peterson

Scripps Senior Theses

Communication inequities are known to negatively impact people from socioeconomically and linguistically disadvantaged backgrounds during public health crises (Gomez-Aguinaga et al., 2021). In the United States, Hispanics—especially those who speak Spanish—have been among the communities most disproportionately affected by COVID-19 (National Center for Health Statistics, 2022). The pandemic has underscored the importance of understanding the linguistic and discursive strategies implemented by institutions entrusted with disseminating public health information to reach diverse audiences, especially the most vulnerable. This paper analyzes the linguistic practices used to create public service announcements (PSA) produced in English and Spanish by health agencies at both the …

From Smallpox To Covid-19: Social And Legal Responses To Vaccinations And Vaccine Mandates, Janet L. Dolgin

Hofstra Law Faculty Scholarship

No abstract provided.

Identifying Host-Intrinsic Resistance Mechanisms To Therapeutic Anti-Tumor Antibody, James Edward Glassbrook

Wayne State University Dissertations

The use of monocloncal antibodies (mAbs) directed at tumor-associated antigens (TAA), often termed “targeted immunotherapy” has revolutionized cancer treatment, markedly improving patient outcomes. As a prime example, the mAb trastuzumab targets human epidermal growth factor 2 (HER2). Like many targeted immunotherapies, only a subset of patients with HER2+ cancer exhibit long-term benefit from trastuzumab. In addition to tumor-intrinsic factors, such as HER2 heterogeneity, we hypothesize that host genetics may influence subsequent immune activation after treatment. To model this interaction, we utilized the genetically heterogeneous Diversity Outbred (DO) mouse model in an F1 cross with BALB/c (producing DOCF1 mice). This cohort …

Power And Sample Size Calculations For Evaluating Spillover Effects In Networks With Non-Randomized Interventions, Ke Zhang

Open Access Master's Theses

Determining the appropriate sample size that is needed to achieve a desired level of statistical power is an integral aspect of study design, as it ensures that studies are adequately powered and that their results are reliable and meaningful. Adequate statistical power can also address some practical and ethical considerations. Various methodologies for power and sample size calculations have been developed for distinct types of studies. However, the implications for power when estimating spillover effects in sociometric network-based studies with non-randomized interventions (SNS-NRIs) remain inadequately explored. In this study, we first conducted a series of simulations to evaluate how the …

Recovering The Full Network Using A Sampling Bias Adjustment In Sampled Network, Ryan Humphreys

Open Access Master's Theses

This project aimed to investigate the differences in terms of network structural characteristics between full and sampled networks and to develop a new weighted generalized estimating equations model (WGEE) in order to mitigate the sampling bias and obtain less biased sample estimates for model coefficients and standard errors. The applications of such an approach are of interest in the field of network analysis and public health studies. The Transmission Reduction Intervention Project (TRIP) is an HIV study using risk networks and is a key motivator for this work. Two other motivating examples were constructed where it was found that sampled …