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Compensating Differentials For Occupational Health And Safety Risks: Implications Of Recend Evidence, W. Kip Viscusi, Thomas J. Kniesner

Vanderbilt Law School Faculty Publications

The most enduring measure of how individuals make personal decisions affecting their health and safety is the compensating wage differential for job safety risk revealed in the labor market via hedonic equilibrium outcomes. The decisions in turn reveal the value of a statistical life (VSL), the value of a statistical injury (VSI), and the value of a statistical life year (VSLY), which have both mortality and morbidity aspects that we describe and apply here. All such tradeoff rates play important roles in policy decisions concerning improving individual welfare. Specifically, we explicate the recent empirical research on VSL and its related …

Clostridium Tertium Bacteremia In Immunocompetent Patient - Contamination Or True Pathogen?, Heath Donahue

UAB Huntsville Research Day - All Presentations

2023 clinical vignette poster

Histopathological Study On The Effect Of Artemisinin Multiple Doses On The Pathogenesis And Immune Reaction Of Trichinella Spiralis In Albino Rats., Zeinab Dwidar, Hebatallah Mahgoub, Iman Ibrahim, Ahmed El- Shaieb

Mansoura Veterinary Medical Journal

Objective: This study aimed to determine the therapeutic effect of multiple doses of artemisinin (AR) on the pathogenesis and immune reaction of (T. spiralis ) during the intestinal and muscular phases in albino rats. Design: Randomized controlled study. Animal Models: The experiment was performed on 80 adult male and female albino rats weighing (160 ± 20 g) and their ages ranged from (4-6 to) weeks. . Procedures: rats were divided into four experimental groups (20 rats per group). 1-(Control negative) group. 2- T. spiralis infested (TR) group: Each animal was orally infested with 300 T. spiralis larvae. 3- T. spiralis …

Development Of Foot And Mouth Disease Vaccine Formulation In Egypt By Using Silver Nanoparticles As Immunogenic And Adjuvant, Rania Dweek, M. Eisa, M. El-Beskawey, Sabry El- Khodery, Abdelaziz A. Yassin, Mohamed Farghli, Hiam Fakhry, Samar Attwa

Mansoura Veterinary Medical Journal

OBJECTIVE: To evaluate the effect of silver nanoparticles (AgNPs) combined with Foot and Mouth Disease (FMD)

inactivated oil adjuvant vaccine on the immunological response of cattle.

STUDY DESIGN: Randomized clinical trials.

PROCEDURES: AgNPs were prepared and added to the locally produced inactivated trivalent FMD vaccine used in

Egypt. Twenty-five cattle were classified into five groups (five/group). The first group was vaccinated with FMD

Trivalent inactivated oil adjuvant vaccine plus AgNPs (3 ml subcutaneously (S/C), the second group was vaccinated with

FMD trivalent inactivated vaccine (3 ml S/C). The third group was vaccinated with FMD trivalent inactivated vaccine plus AgNPs (2 …

Recent Detection And Genotypic Characterization Of Duck Hepatitis Virus A Type 1and H5 Avian Influenza Virus From Ducks., Alshaymaa A. Elhoseny, Samah M. Mosad, Ali A. Elkenawy, Sahar E. Abdelrahmn

Mansoura Veterinary Medical Journal

Objective: To identify viruses that affect ducks using serological and molecular studies. Design: Diagnostic study. Procedures: Twenty pooled liver samples were collected from ducklings with nervous signs and high mortality suspected to be infected by duck hepatitis virus (DHV) for less than 2 weeks. All samples were inoculated into allantoic cavities of SPF embryonated chicken eggs (ECGs) for three successive passages. Isolates were serologically identified by agar gel precipitation (AGPT) and the fluorescent antibody technique (FAT) using DHAV-1 antibodies. In addition, another 20 pooled lung and pancreas samples from ducks for more than one month were suspected to be infected …

Dynamic Connectedness In The Asean’S Equity Markets During The Covid-19 Pandemic, Yuthana Sethapramote, Suthawan Prukumpai, Lawrence B. Dacuycuy

DLSU Business & Economics Review

The COVID-19 pandemic unleashed shocks that triggered severe global economic contraction and spawned sizeable financial market fluctuations. This paper examines the dynamic connectedness between ASEAN stock markets and major global stock markets using the dynamic connectedness framework developed by Diebold and Yilmaz (2009, 2012). Empirical results reveal that ASEAN stock markets and other emerging markets have experienced higher spillovers from global equity markets during the pandemic than in normal times. In addition, the role of ASEAN region spillovers has increased significantly during the COVID-19 outbreak. This study contributes to the existing literature by investigating the extent of dynamic connectedness between …

Tuberkulosis Di Indonesia: Apakah Status Sosial-Ekonomi Dan Faktor Lingkungan Penting?, Amalia Kusumaningrum, Grace Wulandari, Achmad Kautsar

Jurnal Ekonomi dan Pembangunan Indonesia

This study aims to find the social-economic status and environmental factors for tuberculosis in Indonesia by using Indonesia Family Life Survey (IFLS) data in 2014. First, this study analyzes individual characteristics with regression logistic method. Second, this study estimating social-economic status by entering a correction from the first stage. Meanwhile at the third stage, adding factors home environmental conditions and entering a correction from the previous stage. This study find that household income is the affecting factors, especially for households with incomes of less than IDR 600.000. In additions, level education especially high school and college also has a significant …

Masking Vulnerability: Including Ppe As A Covered Service In Health Insurance, Mary Leto Pareja

Faculty Scholarship

The COVID-19 pandemic laid bare the shared vulnerability inherent in the human condition, prompting a collective recognition of our physical susceptibility to infectious diseases. While great strides have been made in combating COVID-19 through vaccinations and treatments, a portion of the population remains profoundly vulnerable due to health conditions that make the disease more dangerous, that limit vaccine efficacy, or that prevent vaccination altogether. This article explores a path forward by proposing a solution within health benefit plans—encompassing both private health insurance and public health benefits. Specifically, the article advocates for a coverage mandate for over-the-counter personal protective equipment (PPE) …

A Review On Fungal Nanoparticales As Antimicrobial Agents To Control Oral Biofilms, Abdulridha Taha Sarhan, Ali Mihsen Alyassiri, Hajir Hassn Hussen

Hilla University College Journal For Medical Science

A variety of materials and drugs have been used in dental care to protect the oral cavity from microbial activities, particularly the formation of dental biofilms. These compounds have the potential to be harmful to the human body. Despite these challenges, nanotechnology applications in dentistry have been developed and used with some success in the improvement of restorative materials. It also focuses on several problematic parts of dental care, like oral biofilm communities, and also how nanotechnology may assist overcome these obstacles. Nanoparticles (NPs) are frequently used in the medical sector for a numerous application, and investigations have already shown …

Antimicrobial Prescriptions By Practicing Physicians In Southern District, Babylon Governorate And Its Correlates, Hasan Alwan Baiee

Hilla University College Journal For Medical Science

Background :There is a worldwide agreement that to address the problem of antimicrobial including antibiotic resistance proper management of antibiotics across all sectors is required.

Objective of the study: To identify the antimicrobial prescribing practice of Iraqi physicians.

Methodology: This study was a cross-sectional descriptive study, the data collected by trained researchers based on reviewing the available prescriptions sheet dispensed by pharmacists after obtaining their verbal consents and protecting the privacy autonomy of patients. The period of this study started from the first of January through the end of May 2021. Antimicrobials and the number of and types of drugs …

Prevention Of Covid-19 Transmission In Dental Healthcare Settings: A Review, Abdulridha Taha Sarhan, Ali Mihsen Alyassiri

Hilla University College Journal For Medical Science

Dentistry is one of the most exposed professions to respiratory diseases e.g. covid-19 and due to its airborne transmission, aerosols created by dental treatment of infected individuals have become a potential chance of transmission. The aim of this review was to assess the existing infection control measures taken in dental healthcare settings, minimizing treatment mistakes and improving the measures of infection transmission. Literature addressing about the prevention of COVID-19 infection transmission in dental healthcare settings, personal safety and hygiene measures, personal protection equipment, surface asepsis, instrument processing, patient treatment with proper disinfection of the working place and the dental instruments …

Molecular Phylogenetics Of Aedes Aegypti (L., 1762) (Diptera: Culicidae) In Eastern Black Sea Area Of Turkey And Possible Relations With The Caucasian Invasion, Murat Öztürk, Muhammet Mustafa Akiner

Turkish Journal of Zoology

Aedes aegypti (L., 1762) (Diptera: Culicidae) is an important pest for human health. It vectors many diseases, including yellow fever (YF), dengue (DENV), and chikungunya (CHIKV). This species has invaded numerous countries including Balkan and Caucasian countries few past decades. The established populations of species were found in Turkey in 2015. We investigated the genetic variation, molecular phylogenetics, and differences between samples from Turkey and Georgia using four mitochondrial and one genomic DNA markers. The possible origin of the species was determined separately for each gene region using maximum likelihood trees. The ML analysis showed a close relation with the …

Seasonal Vulnerability Of Snakes To Road Traffic At Wheeler National Wildlife Refuge, Jackson S. Schoettle

Theses

Snakes are important predators and prey in North American food webs that exhibit seasonal activity patterns in temperate regions. During periods of heightened activity, they will often utilize roads both for traveling from one habitat patch to another and/or for thermoregulation. In this thesis, I explore how human recreational activities impact the diversity and distribution of snake communities by examining the relationships between seasonality of human recreational activities and gravel road closures for waterfowl management on snake road mortality and activity at Wheeler National Wildlife Refuge in northern Alabama, USA. Many studies have investigated how snakes interact with paved roads, …

Access To Hiv Prevention, Care, And Treatment Services In The Us: The Role Of Primary Care, Jessica S. Kiernan

Theses and Dissertations

This dissertation examines the role of access to primary care in benefitting HIV outcomes through increased access to HIV prevention, care, and treatment services, among populations disproportionately affected by HIV in the US. Over 30,000 individuals are newly diagnosed with HIV annually in the US and diagnoses are concentrated in specific populations. At an individual-level, ~ 70% of new diagnoses are among gay and bisexual men and of those diagnoses, 70% are among Non-Hispanic Black and Hispanic gay and bisexual men. At a community-level, over 50% of new HIV diagnoses occur in less than 2% of US counties (48), Washington, …

The Hepatic Immunological Pattern Shaped By Dominant-Subdominant Cellular Interactions Creates A Collective Function Beyond The Function Of Each Cellular Constituent To Orchestrate Progression Of Hepatocellular Carcinoma, Nicholas J. Koelsch

Theses and Dissertations

Abundance of data on the role of inflammatory immune responses in the progression or inhibition of hepatocellular carcinoma (HCC) has failed to offer a curative immunotherapy for HCC. This is largely because of taking reductionist approaches and missing the collective function of the hepatic immune system by focusing on specific immune cell types. To this end, we propose that focusing on the dominant-subdominant patterns of the immune cells would allow understanding of the mechanism by which a collective immune function emerges. To identify the collective immune function through a systems immunology perspective, we performed high-throughput analysis of snRNAseq data collected …

The Impact Of Hiv-1 Tat And Morphine On Spatial Distribution Of Drugs In The Brain., Austin M. Jones

Theses and Dissertations

Despite combination antiretroviral therapy effectively suppressing HIV within the periphery, the central nervous system (CNS) remains affected by the virus. Approximately half of people living with HIV will experience HIV-associated neurocognitive disorders (HAND) or neuroHIV. Concurrent opioid use exacerbates neuroHIV by promoting neuroinflammation, viral replication, and potentially altering the antiretroviral concentrations within the brain.

Using a transgenic mouse that expresses the HIV-1 Tat protein, we examined the effects of Tat and morphine on antiretroviral accumulation and distribution and the effects of Tat on morphine accumulation within the brain using infrared matrix-assisted laser desorption electrospray ionization with mass spectrometry imaging (IR-MALDESI-MSI). …

Studying Gene Function In Streptococcus Sanguinis Using Rna-Sequencing Analysis, Ahmed Ismail

Theses and Dissertations

The oral cavity hosts hundreds of bacterial species, amongst them are the Streptococci family. More specifically, S. sanguinis is a benign bacteria in the oral cavity to protect the tooth surface from S. mutans. which is a pathogen causing dental caries. While S. sanguinis is harmless in the oral cavity, it becomes pathogenic once entering the bloodstream and causing Infective Endocarditis (IE). To further study S. sanguinis and eventually develop an effective drug to treat IE caused by S. sanguinis, a gene expression study was conducted. In order to study gene expression, RNA-sequencing was conducted, and appropriate methods to remove …

Transcriptional Coregulation Among Diabetes-Associated Pathways By Genome Organization, Musaddiq K. Lodi

Theses and Dissertations

There are currently 96 million individuals affected by diabetes in the United States alone. Crucial information such as biomarkers, regulatory networks, and metabolic pathways in diabetes still remain an active area of research. The primary focus of this study is on a phenomena known as transcription factor co-regulation. Transcription factors (TFs) are DNA-binding proteins that can control the rate of transcription of genetic information from DNA to mRNA, hence misregulation of one of them can lead to misregulation of many of its target genes and associated pathways. In this study I propose a framework to quantify transcriptional coherence in co-regulated …

Factors Associated With Turnover Intention Of Medical Laboratory Professionals During The Covid-19 Pandemic: A Mixed Methods Approach, Keandra Walthall

Theses and Dissertations

The COVID-19 pandemic disrupted and strained healthcare systems worldwide. Frontline healthcare workers have experienced increased rates of psychological distress and burnout during the COVID-19 pandemic, which have led to high turnover intention and workforce shortages. Medical Laboratory Professionals have endured similar experiences during the COVID-19 pandemic; however, there has been limited research exploring these factors for this group of professionals. This study utilized a convergent mixed methods approach to investigate the impact of psychological distress and burnout on the turnover intentions of Medical Laboratory Professionals in the United States during the COVID-19 pandemic, as well as to explore motivational factors …

Guardianship Before And Following Hospitalization, Jennifer Sullivan, Andrew B. Cohen, Kelly Stolzmann, Elizabeth J. Auguste, Casey C. Catlin, Zachary S. Sager, Rachel E. Weiskittle, Cindy B. Woolverton, Heather L. Connors

Publications

When ethics committees are consulted about patients who have or need court appointed guardians, they lack empirical evidence about several common issues, including the relationship between guardianship and prolonged, potentially medically unnecessary hospitalizations for patients. To provide information about this issue, we conducted quantitative and qualitative analyses using a retrospective cohort from Veterans Healthcare Administration. To examine the relationship between guardianship appointment and hospital length of stay, we first compared 116 persons hospitalized prior to guardianship appointment to a comparison group (n=348) 3:1 matched for age, diagnosis, date of admission, and comorbidity. We then compared 91 persons hospitalized in the …

Fair Domestic Allocation Of Monkeypox Virus Countermeasures, Govind Persad, R. J. Leland, Trygve Ottersen, Henry S. Richardson

Publications

Countermeasures for mpox (formerly known as monkeypox), primarily vaccines, have been in limited supply in many countries during outbreaks. Equitable allocation of scarce resources during public health emergencies is a complex challenge. Identifying the objectives and core values for the allocation of mpox countermeasures, using those values to provide guidance for priority groups and prioritisation tiers, and optimising allocation implementation are important. The fundamental values for the allocation of mpox countermeasures are: preventing death and illness; reducing the association between death or illness and unjust disparities; prioritising those who prevent harm or mitigate disparities; recognising contributions to combating an outbreak; …

Computational Studies On Molecular Mechanisms For Dysregulation Of Monoamine Transporters By Hiv-1 Tat And Drug Discovery Of Novel Phosphodiesterase-2 Inhibitors, Charles A. Adeniran

Theses and Dissertations--Chemistry

Computational chemistry methods have been greatly used and has great potential in drug discovery and understanding the detailed molecular mechanism of biological processes. Scientific questions can initially be addressed using computational modeling and simulation studies. The common feature in this work is to understand intermolecular interactions related to protein targets in the brain, as it relates to HIV infection and Alzheimer’s Disease. HIV is among the world’s most deadly infectious diseases. Recent therapeutic advancements have begun to increase the life expectancy of people living with this virus. The mechanisms that lead to neurobiological complications known as HIV- associated neurocognitive disorders …

Evaluating The Contribution Of Adjacent Charges On The Observed Ph-Dependent Binding Profile For A Vhh/Antigen Interaction With A Linked Histidine Protonation Equilibria, Kiruthika Arulmoly

Graduate Research Theses & Dissertations

pH dependent protein-protein interactions are of great importance for various biological processes. In addition, the generation of engineered pH-dependent therapeutic antibodies opens opportunities for the extension of therapeutic half-life, thereby reducing drug dosage or frequency of administration, as well as providing pH-dependent targeting, such as the tumor microenvironment. Engineering pH-dependent antibody-antigen interaction is mostly achieved through the incorporation of ionizable residues within the antigen binding interface. These ionizable residues must undergo a change in environment upon forming a protein-protein complex, which causes a change in the ionizable group’s pKa value. This coupled protonation equilibria is responsible for the observed pH-dependent …

Grey To Green: The Impact Of Environmental Policy On Us Crime Rates, Kassandra Gonzalez

Graduate Research Theses & Dissertations

This study explores the social implications of climate change and environmental degradation on deviant and criminal behavior. This study employs general strain theory to examine the effectiveness of city-level climate change mitigation actions in reducing crime rates. Through a systematic approach, this study reviews literature on environmental harms and community strain and explores the impact of local pro-environmental policies on crime reduction. Focusing on the United States, UCR crime rate reports and UN-guided Sustainable Development Goal data are analyzed at the US county level. The findings suggest that sustainable practices, especially those related to local infrastructure and community engagement, could …

I. Design, Synthesis, And Evaluation Of The Human Phoshodiesterase-4 And Fungal Acetyl Coa Synthetase Enzyme Inhibitors Ii. Evaluation Of Biological Activity Of Kenyan Medicinal Plants, Chaitanya Kondam

Graduate Research Theses & Dissertations

Phosphodiesterase-4 (PDE4) enzyme mainly present in immune cells, epithelial cells, and brain cells that regulate inflammation and epithelial integrity in cells. Inhibition of PDE4 enzyme leads to regulation of various inflammatory mechanisms by elevation of cyclic adenosine monophosposphate (cAMP) levels in the cells. PDE4 enzyme is promising target for treatment of pulmonary, dermatological, and neurological inflammatory diseases. Several PDE4 inhibitor drugs Roflumilast, Apremilast, and Crisaborole were approved and marketed as Dalsirep, Otezla and Eucrisa for the treatment of inflammatory pulmonary diseases, psoriatic arthritis, and atopic dermatitis. However, these drugs have adverse effects such as nausea, emesis, and gastrointestinal effects. Benzothiazole …

Using The Best - Worst Scale To Assess The Relative Impact Of These Behaviors On Other Passengers On The Same Flight: The Disruptive Passenger Behavior, Quynh Thi Nhu Phan, Vi Tran, Nhan Huu Huynh, Thao Phuong Huynh, Duc Nhan Ho

International Journal of Aviation, Aeronautics, and Aerospace

A method called the best-worst scaling method is proposed to overcome these problems by asking respondents to make tradeoffs among the variables being assessed. This paper raises issues in respect of supplementing and developing a block of disruptive behaviors exhibited by passengers during flights and assesses the impact of these behaviors on other passengers. To illustrate the proposed method and evaluate its performance, we surveyed 240 passengers, and data from 203 survey samples were analyzed. The data analysis results revealed three behaviors that were considered the most disruptive, including (1) Threatening and causing distress, (2) Harassment and disrupting public order, …

Editorial: Microglia In Neuroinflammation, Pinar Ayata, Ido Amit, Carla M. Cuda

Advanced Science Research Center

Microglia are a resident innate immune cell population of the central nervous system (CNS) derived from yolk sac erythro-myeloid progenitors that migrate to the developing brain prior to the formation of the blood-brain barrier. This critical cell population has gained considerable traction in the literature as it is considered a protective barrier from CNS damage and, yet, can also serve as a primary mediator of neuroinflammation. Under normal physiological conditions, microglia perform homeostatic functions, such as parenchymal surveillance, neurotrophic support, pathogen or debris removal, and maintenance of synaptic homeostasis and neuronal plasticity.

Pachamama Over People And Profit: A Case For Indigenous Ecology And Environmental Personhood, Hilda Loury

American Indian Law Review

No abstract provided.

Human Immunodeficiency Virus Type 1 Rna Genital Tract Shedding After Cryotherapy For Cervical Intraepithelial Neoplasia In Western Kenya, Elkanah Omenge, Anne Bocage, Tao Liu, Peter Itsura, Philip Tonui, Kapten Muthoka, Stephen Kiptoo, Angela Caliendo, Soya Sam, Susan Cu-Uvin

Obstetrics and Gynaecology, East Africa

Abstract :This prospective study of 39 women living with human immunodeficiency virus (HIV) on antiretroviral therapy in Western Kenya aimed to quantify genital tract HIV-1 RNA (GT-HIV RNA) shedding before and after cryotherapy for cervical intraepithelial neoplasia. Most GT-HIV RNA shedding was detected precryotherapy, suggesting that cryotherapy was not the primary cause of shedding.

Russian And U.S. News Media Coverage Of Ukrainian Biological Laboratories, February – March 2022, Annie E. Sundelson, Marc Trotochaud, Noelle Huhn, Tara Kirk Sell

Journal of Strategic Security

Soon after the Russian invasion of Ukraine, narratives about U.S.-funded biological weapons laboratories in Ukraine began circulating in both Russian and U.S. news. We sought to characterize news media coverage of this topic and to understand potential differences in coverage between different news sources. 401 news media items from Russian and U.S. news sources covering Ukrainian biological laboratories between February 24 and March 24, 2022 were analyzed for content and framing tactics based on theories of risk perception, persuasion, and misinformation/disinformation. Results showed strong differences between U.S. mainstream news coverage and Russian news coverage and similarities between U.S. hyper-partisan right …