Digital Commons Network^™

Sars-Cov-2 Seroprevalence In Pregnant Women In Kilifi, Kenya From March 2020 To March 2022, Angela Koech, Geoffrey Omuse, Alex Mugo, Isaac Mwaniki, Joseph Mutunga, Moses Mukhanya, Onesmus Wanje, Grace Mwashigadi, Geoffrey Katana, Marleen Temmerman

Centre of Excellence in Women and Child Health

Background: Seroprevalence studies are an alternative approach to estimating the extent of transmission of SARS-CoV-2 and the evolution of the pandemic in different geographical settings. We aimed to determine the SARS-CoV-2 seroprevalence from March 2020 to March 2022 in a rural and urban setting in Kilifi County, Kenya.

Methods: We obtained representative random samples of stored serum from a pregnancy cohort study for the period March 2020 to March 2022 and tested for antibodies against the spike protein using a qualitative SARS-CoV-2 ELISA kit (Wantai, total antibodies). All positive samples were retested for anti-SARS-CoV-2 anti-nucleocapsid antibodies (Euroimmun, ELISA kits, NCP, …

Investigating The Role Of Maternal Adiposity On Human Breast Milk And Preterm Infant Stool Short Chain Fatty Acid And Microbiome Profiles, Kristy L. Thomas

Electronic Theses and Dissertations

Preterm birth is the number one cause of death in neonates, accounting for 35% of neonatal mortality. The preterm birth rate in the U.S. in 2021 was 10.5%, disproportionally affected by race and ethnicity. Obese women have an increased risk of preterm pregnancy, and if delivered before 37 weeks of gestation, the offspring have higher rates of complications that extend from the neonatal period into life-long metabolic and immune adverse outcomes. In the early months after delivery, preterm infants have higher rates of adverse health outcomes than term infants, including infections, extrauterine growth restrictions, respiratory, metabolic, and neurological complications, necrotizing …

Improving Implant Training For Physicians And Their Teams In Under-Represented Regions, Jeilan Mohamed, Mohamed Varwani, Abdul Raqib, Emin Evren Ozcan

Internal Medicine, East Africa

The burden of cardiovascular disease is increasing globally, with low- and middle-income countries (LMICs) absorbing most of the burden while lacking the necessary healthcare infrastructure to combat the increase. In particular, the disparity in pacemaker implants between high-income countries and LMICs is glaring, partially spurned by reduced numbers of physicians and supporting staff who are trained in pacemaker implant technique. Herein, we will discuss current pacemaker implant training models, outline training frameworks that can be applied to underserved regions, and review adjunctive training techniques that can help supplement traditional training models in LMICs.

Parent Choice: Learning Pods Or Public Education During Covid-19 Pandemic, Shari Kinney

Electronic Theses and Dissertations

The purpose of this phenomenological qualitative study was to examine the decision-making process of K-12 parents living in the Appalachian Highlands who chose to remove their children from traditional public schools to join learning pods (sometimes referred to as pandemic pods) during the COVID-19 pandemic. In order to answer this overarching question, the researcher focused her study on two areas: first, what were the possible push factors that influenced parents to remove their children from public schools, and secondly, what were the pull factors that lead parents to choose learning pods over other school choice options. Through the data collected …

Synthesis And Characterization Of Silver-Coated Polyester Dendrimers With Potential Antimicorbial Properties, Che’Darria Lacey

All Theses

As bacterial cell lines continue to develop resistance to conventional antibiotic medications, the threat of untreatable bacterial infections continues to grow. The limited manufacture of new pharmaceuticals further exacerbates this severe health risk. This risk has facilitated numerous investigations to counter microbial species’ antibiotic resistance. The use of silver, a well-known natural remedy, has grown significant attraction through its use in the nanoparticle form or even as silver ions.

This thesis project involves the synthesis of branched polymers that were suitably functionalized to enable the complexation of silver ions to develop antimicrobial materials. Polyester dendrimers were synthesized utilizing divergent dendronization. …

Polluting The Senses: The Impact Of Noise And Light Pollution On Fledgling Movement And Evolution Within The Avian Eye, Margaret C. Mackinlay

Master's Theses

There is more human-generated noise and light today than ever before, a trend tied to ongoing urbanization and with reverberating impacts on a wide range of organisms. While research on these impacts is mounting and particularly plentiful when it comes to birds, there is still much to explore within its effects on avian behavior, fitness, and evolution. In chapter 1, we investigated how fledgling movement is influenced by noise and light pollution. While adult birds have well-documented species-specific responses to these stimuli, fledglings are sorely understudied in this context. We experimentally manipulated light levels and took advantage of an existing …

Evaluating Lack Of Access To Secondary Prevention-Based Healthcare Services Between Racial/Ethnic Groups In The United States: A Logistic Regression Analysis Using 2022 Brfss Cross-Sectional Data, Samuel Ortiz Severiano

Capstone Experience: Master of Public Health

Objective: To determine whether racial/ethnic minorities have reduced access to preventive healthcare services in the United States, with participation in routine checkups serving as the metric for access. Methods: Performing logistic regression analysis comparing the length of time since the last routine checkup between different racial/ethnic groups in the study population. Those who haven’t had a routine checkup in at least 12 months served as the comparison group. Results: Black populations were 66% less likely to not have access to preventive care compared to White populations, while Asian, American Indian/Alaskan Native, and Native Hawaiian/Pacific Islander populations were 8.5% more likely …

Associations Between Long Covid And Healthcare Access: A Cross-Sectional Analysis Of The Behavioral Risk Factor Surveillance System (Brfss) 2022, Tiffany Elliott

Capstone Experience: Master of Public Health

Objective. To evaluate the association of healthcare access with Long COVID and clinical and sociodemographic factors.

Methods. Data were from the CDC's 2022 Behavioral Risk Factor Surveillance System (BRFSS) surveys regarding four measures of healthcare access and Long COVID. There were 25,549 respondents who reported Long COVID and 95,830 respondents who did not report Long COIVD.

Results. 25,549 (22.0%) of respondents reported Long COVID. Significant associations were found in respondents with public health insurance and delayed medical care due to cost. Those with chronic health conditions were more likely to report Long COVID. Women, certain racial/ethnic groups, …

Rsif Tanzania Country Report 2023, Regional Scholarship And Innovation Fund (Rsif)

Rsif Country Progress Reports

Tanzania’s GDP is projected to rise to 6.3% in 2024. Higher public education spending would contribute to boosting human capital and social inclusion in line with the ambition of Tanzania’s Vision 2025 as well as the UN Sustainable Development Goals. World-class scientists and skills development that matches business demand combined with an improved business environment hold promising potential for quality jobs and improved livelihoods. Tanzania is one of eleven African countries that are active in the Partnership for skills in Applied Sciences, Engineering and Technology (PASET), and has expressed its intention to contribute to the Regional Scholarship and Innovation Fund …

Analyzing The Impacts Of Beaver Dam And Beaver Dam Analog Complexes To Stream Ecology Within The Intermountain West, J. Marshall Wolf

All Graduate Theses and Dissertations, Fall 2023 to Present

Streams, rivers, and their floodplains throughout the world are impaired due to human modifications. Recent research has demonstrated that restoration projects prioritizing the proper functioning of ecosystems have better restoration outcomes than projects which focus on restoring form alone. Throughout North America, beaver-mediated restoration is becoming a leading method for improving the functioning of stream ecosystems that are in a degraded state. In areas where beaver are absent or the habitat is too degraded to currently permit their dam building, man-made beaver dam analogs (BDAs) are being used to restore stream habitat with an eye to future beaver recolonization. However, …

Characterization Of The Long-Distance Dispersal Kernel Of White-Tailed Deer And Evaluating Its Impact On Chronic Wasting Disease Spread In Wisconsin, Mennatallah Gouda

All Graduate Theses and Dissertations, Fall 2023 to Present

Chronic Wasting Disease (CWD) is a fatal, untreatable neurodegenerative disease that infects deer and related species. It is highly contagious and caused by abnormal malfunction and assembly of normal cellular proteins into aggregation-prone proteins. The Centers for Disease Control and prevention report that the prevalence of CWD in free-ranging deer in the US is still relatively low. However, in several states the infection rates exceed 1 deer in 10. Deer may uptake CWD from direct interaction with infected individuals or from the environment. Infected individuals shed CWD into the environment through feces, urine, saliva or carcasses, and long-distance dispersal of …

Differences In Mental Health Outcomes And Services By Gender Identity Among Sexual And Gender Minorities During The First Shelter-In-Place Order Of The Covid-19 Pandemic In Texas, 2020, Mariah Victoria Alvarez Ramirez

Open Access Theses & Dissertations

Background: Within the United States, sexual and gender minorities (SGM), face unique barriers when seeking health services, such as uninsurance, postponing care, and lack of competent services. Within SGM, transgender and gender-expansive (TGX) individuals are more vulnerable as they have higher rates of discrimination and face more barriers to accessing healthcare services. Purpose: Identify differences in mental health outcomes and services by gender identity among sexual and gender minorities residing in Texas during the COVID-19 pandemic. Methods: This study is a secondary data analysis of the SGM participants of the COVID-19 and You Survey study (n=1288). Descriptive statistics, bivariate associations …

Covid-19 Prevention, Testing, And Treatment Seeking Among People Who Inject Drugs (Pwid) On The Us Mexico Border, Jorge Raul Puentes

Open Access Theses & Dissertations

The outbreak of the COVID-19 pandemic exacerbated the negative social determinants of health that affect medically underserved people who inject drugs (PWID) inhibiting their access to services, promoting infectious disease acquisition such as HIV and HCV, and overdose rates. The effects of the pandemic were more pronounced among Latino PWID communities. Participants of this study are 194 PWID residing in El Paso, Texas, and Cd. Juarez, Chihuahua along the US-Mexico border. Cross-sectional surveys were administered assessing environmental risk factors that impact COVID-19 acquisition and engagement in preventive behaviors. The purpose of this secondary data analysis study was to describe the …

Neural Damage Following Francisella Tularensis Infection, Anahis Tena

Open Access Theses & Dissertations

This dissertation investigates the impact of Francisella tularensis infection on the brain, focusing on its anatomical localization, effects on synaptic health, and behavioral and cognitive consequences in mice. Employing a combination of fluorescent tagging, confocal and light sheet microscopy, the study first maps bacterial foci within the brain, anticipating a concentration in the limbic system, particularly the hippocampus. Subsequently, it examines synaptic function post-infection using calcium imaging in various neuronal cultures, expecting a decrease in calcium signaling indicative of synaptic impairment. Finally, behavioral assays like the forced swim test, object recognition test, and Morris Water Maze assess the cognitive and …

The Perpetuation Of Hiv Risk In Latinx Immigrations: A Cross-National Perspective, J. M. Aleman

Open Access Theses & Dissertations

Research indicates that migration is a social determinant of health that increases the risk of acquiring HIV. What is less understood, however, are the pathways through which immigration influences HIV risk. This study employed a cross-national perspective and utilized a social determinants of health framework to understand how structural factors, such as economic conditions and immigration policies and their enforcement, influence HIV risk among migrants. While mobility, migration and displacement are associated with increased HIV risk, they are not inherently the cause but rather a condition under which vulnerability is increased indicating that other distal, upstream, or structural forces are …

A Noninvasive Urine-Based Method For Kidney Cancer Early Detection, Kiana Holbrook

Open Access Theses & Dissertations

Based on the traditional serological uses to obtain diagnoses of cancer and biopsy techniques, common cancer detection could be not only invasive but expensive and some tests are also unreliable. Currently, urine is one of the most frequently used and collected specimens in the clinical diagnoses. While the areas of urinalysis and metabolomic profiling has received interest in the top clinical research, there are limited components to the validity, specificity, as well as sensitivity of endogenous urine substrates to detect early stages of cancers. Although there is research showcasing that urine is impacted by age, cancer type, geographical location, and …

Evaluation Of The Efficacy Of Synthetic Glycovaccines Against Both Murine Acute Chagas Disease And Cutaneous Leishmaniasis, Colin D. Knight

Open Access Theses & Dissertations

Chagas disease (CD) and cutaneous leishmaniasis (CL) are neglected tropical diseases caused by the protozoan trypanosomatids, Trypanosoma cruzi and Leishmania spp., respectively. There are approximately 6-8 million people infected with T. cruzi worldwide and ~300,000 people in the US. Between 700,000 and 1.2 million new cases of CL occur worldwide yearly. The approved chemotherapies for both diseases are partially effective and may cause serious adverse events, resulting in premature treatment interruption. Moreover, no effective vaccine for either disease is available. Therefore, developing a vaccine that would provide effective cross-protection against both diseases would provide a cost-effective alternative to the existing …

Traditional And Emerging Modifiable Lifestyle Risk Behaviors For Non-Communicable Diseases In A Sample Of Hispanic/Latino American Adolescents Living In The U.S.-Mexico Border Region, Silvia Salinas Lopez

Open Access Theses & Dissertations

Background: Non-communicable diseases (NCDs) pose a significant global health threat, with modifiable lifestyle risk behaviors (mLRBs) contributing substantially to their onset. This study examined traditional and emerging mLRBs and their distribution on cross-sectional health outcomes among Hispanic/Latino in-school adolescents living on the U.S.-Mexico border. Methods: This secondary data analysis used information from the cross-sectional 2019 El Paso YHBS obtained through online surveys. The secondary data analyzed the prevalence, clustering, and co-occurrence of mLRBs of 539 Hispanic/Latino high school students. Results were compared to mLRBs findings corresponding to Hispanic/Latino adolescents who participated in the national and state 2019 CDC YRBSS. An …

Assessment Of A Pharmacist-Led Antibiotic Time-Out For Transition Of Iv Vancomycin To Oral Linezolid, Mary S. Vogel, Jefferson Cua, Erika Dittmar, Timothy Gauthier, Kelsey N. Williams

Nursing & Health Sciences Research Journal

Introduction: Intravenous (IV) vancomycin requires therapeutic drug monitoring and line placement and may prolong hospital stay. Linezolid requires less monitoring, is orally bioavailable, and may expedite transitions of care. This study assessed the impact of a pharmacist-led antibiotic timeout for the transition from IV vancomycin to oral linezolid. Methods: This single-center, quasi-experimental study included admitted adult patients receiving IV vancomycin for over 48 hours. Patients receiving vasopressors, of immunocompromised status, or with specific antibiotic indications were excluded. The primary outcome was the pharmacist intervention acceptance rate. Secondary outcomes included median hospital length of stay, median antibiotic treatment days, and incidence …

A Cross-Sectional Study On The Impact Of The Covid-19 Pandemic On Sport-Related Concussion Clinical Presentation Within Adolescents And Adults, Emily Mcindoe

Graduate Theses and Dissertations

Introduction. The COVID-19 pandemic spanned across the globe in March 2020 and has since significantly impacted human life. There is evidence that supports symptom exacerbation and an increase in anxiety and depression in clinical presentation post-COVID-19 pandemic compared to pre-COVID-19 for multiple medical diagnoses. These medical diagnoses include migraines, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and mild cognitive impairment. The effect that the pandemic had on the clinical presentation of sports-related concussions is understudied. It is possible that the COVID-19 pandemic has altered the clinical presentation of concussions as seen in other medical diagnoses. Given the increased reporting of …

The Needs That Instagram Satisfies For People Seeking News & How This Displaces Time Spent With Traditional Media, Madeleine Dunn

Graduate Theses and Dissertations

This paper examines how the current climate of mainstream media is changing, and how this may affect journalistic norms and practices. There are many outlets for consumers to receive news, including traditional media, such as television news, newspapers, magazines, etc. There is also social media. The future of mainstream media outlets, like television stations, newspapers, magazines and radio stations, seems to depend on the growing use of social media sites for the use of getting news. This research will focus on Instagram as an alternative to traditional media, and why people prefer to use this outlet to get their news. …

Prevalence And Missed Cases Of Respiratory Distress Syndrome Disease Amongst Neonatal Deaths Enrolled In The Kenya Child Health And Mortality Prevention Surveillance Network (Champs) Program Between 2017 And 2021, Harun O. Owuor, Victor Akelo, Florence Murila, Dickens Onyango, Magdalene Kuria, Emily Rogena, Gunturu Revathi, Paul Mitei, Solomon Sava, Joyce Were

Pathology, East Africa

Objectives: To describe RDS in neonatal deaths at the CHAMPS-Kenya site between 2017 and 2021.

Methods: We included 165 neonatal deaths whose their Causes of death (COD) were determined by a panel of experts using data from post-mortem conducted through minimally invasive tissue specimen testing, clinical records, and verbal autopsy.

Results: Twenty-six percent (43/165) of neonatal deaths were attributable to RDS. Most cases occurred in low birthweight and preterm neonates. From these cases, less than half of the hospitalizations were diagnosed with RDS before death, and essential diagnostic tests were not performed in most cases. Most cases received suboptimal levels …

Does Maternal Mental Health (Anxiety And Depression) Negatively Impact Exclusive And Continued Breastfeeding Practices?, Smriti Neupane

UNLV Theses, Dissertations, Professional Papers, and Capstones

Exclusive and continued breastfeeding practices are the optimal source of nutrition for an infant's well-being, cognitive growth, and development and have positive health outcomes for the mother too. Anxiety and depression are common perinatal mental health conditions associated with early breastfeeding interruption. However, Nevada lacks data on perinatal mental health and its influence on breastfeeding practices. The objective of this study was to assess whether maternal mental health (anxiety and depression) impacts exclusive and continued breastfeeding practices in Clark County, Nevada. A cross-sectional survey was conducted with 358 mothers having children 0-23 months old and residing in Clark County, Nevada. …

Influenza Viral Infection Is A Risk Factor For Severe Illness In Covid-19 Patients: A Nationwide Population-Based Cohort Study, Jeong-Hwan Hwang, Yeon Seok You, Sang Woo Yeom, Min Gyu Lee, Jong-Hwan Lee, Min Gul Kim, Jong Seung Kim

Faculty, Staff and Student Publications

In order to prepare for the twindemic of influenza and SARS-CoV-2 infection, we investigated the association between influenza infection and subsequent severity of SARS-CoV-2 infection. A population-based nationwide cohort study was performed using data from the National Health Insurance Service (NHIS) in the Republic of Korea. This study included 274,126 individuals who underwent SARS-CoV-2 PCR testing between 20 January 2020 and 1 October 2020. Among these patients, 28,338 tested positive for SARS-CoV-2, and 4,003 of these individuals had a history of influenza. The control group was selected through 1:1 propensity score matching. In the group of 4,003 COVID-19-positive individuals with …

Psychological Effects Of Immigration: A Comprehensive Review Exploring Social Identity, Acculturation And The Effects Of Cultural Attitudes And Systemic Factors On The Well-Being Of Immigrants, Huda Abu Nasab

Honors Program: Senior Projects (Public)

Immigration is a life-altering experience that can greatly affect an individual's identity, sense of belongingness, and well-being. The United States is known as a nation of immigrants; however, many immigrants have faced challenges related to assimilation and the development of their social identities in a new society. For example, immigration challenges often include adapting to a new culture, learning a different language, and navigating unfamiliar healthcare and educational systems. There are many factors that influence how immigrants adjust in their host country, such as acculturation challenges, cultural attitudes towards immigrants, and the availability of essential resources. This literature review aims …

Localization, Tissue Biology, And T Cell State — Implications For Cancer Immunotherapy, Jason M Schenkel, Kristen E Pauken

Faculty, Staff and Student Publications

Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-dependent killers, which requires them to physically be within the tissue of interest to kill peptide-MHC class I-bearing target cells. Following their migration and extravasation into tissues, T cells receive many extrinsic cues from the local microenvironment, and these signals shape T cell differentiation, fate and function. Because major organ systems are variable in their functions and compositions, they apply disparate pressures on T cells to adapt to the local microenvironment. Additional complexity arises in the context of malignant lesions (either primary or metastatic), and this …

Immunity Revolution: Training Innate Immunity For Enhanced Defense, Minh Tran Ha

The Synapse: Intercollegiate science magazine

No abstract provided.

Stopping The Revolving Door: Mdp-Based Decision Support For Community Corrections Placement, Xiaoquan Gao, Pengyi Shi, Nan Kong

Research Collection Lee Kong Chian School Of Business

Community corrections (CC) programs offer an alternative to incarceration that can reduce jail overcrowding and recidivism rates. The aim is to address the root causes behind criminal behavior, ultimately breaking the cycle of reincarceration. However, placing all eligible individuals in CC may strain case managers, resulting in reduced supervision, increased violations, and higher recidivism rates, which undermines the intended benefits for all participants in the programs. We take the first step in building a comprehensive analytical framework based on a queueing system to support the placement decisions and related decisions such as capacity planning. We develop a Markov Decision Process …

Effect Of The Announcement Of Human-To-Human Transmission On Teleconsultation Services In China During Covid-19, Mairehaba Maimaitiming, Jingui Xie, Zhichao Zheng, Yongjian Zhu

Research Collection Lee Kong Chian School Of Business

Objectives: Telemedicine enables patients to communicate with physicians effectively, especially during the coronavirus disease (COVID-19) pandemic. However, few studies have explored the use of online health care platforms for a comprehensive range of specialties during the COVID-19 pandemic. This study aimed to investigate how telemedicine services were affected by the announcement of human-to-human transmission in China. Methods: Telemedicine data from haodf.com in China were collected. A difference-in-differences analysis compared the number of telemedicine use and the number of active online physicians for different specialties in 2020 with the numbers in 2019, before and after the announcement of human-to-human transmission. Results: …

Characterization Of Tungiasis Infection And Morbidity Using Thermography In Kenya Revealed Higher Disease Burden During Covid-19 School Closures, Lynne Elson, Abneel K. Matharu, Naomi Riithi, Paul Ouma, Francis Mutebi, Hermann Feldmeier, Jürgen Krücken, Ulrike Fillinger

All Peer-Reviewed Publications

Background: Tungiasis is a neglected tropical skin disease caused by the sand flea Tunga penetrans. Female fleas penetrate the skin, particularly at the feet, and cause severe inflammation. This study aimed to characterize disease burden in two highly affected regions in Kenya, to test the use of thermography to detect tungiasis-associated inflammation and to create a new two-level classification of disease severity suitable for mapping, targeting, and monitoring interventions. Methods: From February 2020 to April 2021, 3532 pupils age 8–14 years were quasi-randomly selected in 35 public primary schools and examined for tungiasis and associated symptoms. Of the infected pupils, …