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2023

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The In Vitro Activity Of Delafloxacin And Comparator Agents Against Bacterial Pathogens Isolated From Patients With Cancer, Bahgat Gerges, Kenneth Rolston, Samuel A Shelburne, Joel Rosenblatt, Randall Prince, Issam Raad Apr 2023

The In Vitro Activity Of Delafloxacin And Comparator Agents Against Bacterial Pathogens Isolated From Patients With Cancer, Bahgat Gerges, Kenneth Rolston, Samuel A Shelburne, Joel Rosenblatt, Randall Prince, Issam Raad

Faculty, Staff and Student Publications

BACKGROUND: Fluoroquinolones are used for infection prevention in high-risk patients with haematological malignancies. Fluoroquinolones are active against many Gram-negative bacilli (GNB) but are less active against Gram-positive organisms. We evaluated the

METHODS: Antimicrobial susceptibility testing and time-kill studies were performed using CLSI-approved methodology and interpretive criteria for 350 Gram-positive organisms and 210 GNB that had been recently isolated from patients with cancer.

RESULTS: Delafloxacin was more active than ciprofloxacin and levofloxacin against

CONCLUSIONS: Delafloxacin is more active than ciprofloxacin and levofloxacin against


A Non-Antibiotic-Disrupted Gut Microbiome Is Associated With Clinical Responses To Cd19-Car-T Cell Cancer Immunotherapy, Christoph K Stein-Thoeringer, Neeraj Y Saini, Eli Zamir, Viktoria Blumenberg, Maria-Luisa Schubert, Uria Mor, Matthias A Fante, Sabine Schmidt, Eiko Hayase, Tomo Hayase, Roman Rohrbach, Chia-Chi Chang, Lauren Mcdaniel, Ivonne Flores, Rogier Gaiser, Matthias Edinger, Daniel Wolff, Martin Heidenreich, Paolo Strati, Ranjit Nair, Dai Chihara, Luis E Fayad, Sairah Ahmed, Swaminathan P Iyer, Raphael E Steiner, Preetesh Jain, Loretta J Nastoupil, Jason Westin, Reetakshi Arora, Michael L Wang, Joel Turner, Meghan Menges, Melanie Hidalgo-Vargas, Kayla Reid, Peter Dreger, Anita Schmitt, Carsten Müller-Tidow, Frederick L Locke, Marco L Davila, Richard E Champlin, Christopher R Flowers, Elizabeth J Shpall, Hendrik Poeck, Sattva S Neelapu, Michael Schmitt, Marion Subklewe, Michael D Jain, Robert R Jenq, Eran Elinav Apr 2023

A Non-Antibiotic-Disrupted Gut Microbiome Is Associated With Clinical Responses To Cd19-Car-T Cell Cancer Immunotherapy, Christoph K Stein-Thoeringer, Neeraj Y Saini, Eli Zamir, Viktoria Blumenberg, Maria-Luisa Schubert, Uria Mor, Matthias A Fante, Sabine Schmidt, Eiko Hayase, Tomo Hayase, Roman Rohrbach, Chia-Chi Chang, Lauren Mcdaniel, Ivonne Flores, Rogier Gaiser, Matthias Edinger, Daniel Wolff, Martin Heidenreich, Paolo Strati, Ranjit Nair, Dai Chihara, Luis E Fayad, Sairah Ahmed, Swaminathan P Iyer, Raphael E Steiner, Preetesh Jain, Loretta J Nastoupil, Jason Westin, Reetakshi Arora, Michael L Wang, Joel Turner, Meghan Menges, Melanie Hidalgo-Vargas, Kayla Reid, Peter Dreger, Anita Schmitt, Carsten Müller-Tidow, Frederick L Locke, Marco L Davila, Richard E Champlin, Christopher R Flowers, Elizabeth J Shpall, Hendrik Poeck, Sattva S Neelapu, Michael Schmitt, Marion Subklewe, Michael D Jain, Robert R Jenq, Eran Elinav

Faculty, Staff and Student Publications

Increasing evidence suggests that the gut microbiome may modulate the efficacy of cancer immunotherapy. In a B cell lymphoma patient cohort from five centers in Germany and the United States (Germany, n = 66; United States, n = 106; total, n = 172), we demonstrate that wide-spectrum antibiotics treatment ('high-risk antibiotics') prior to CD19-targeted chimeric antigen receptor (CAR)-T cell therapy is associated with adverse outcomes, but this effect is likely to be confounded by an increased pretreatment tumor burden and systemic inflammation in patients pretreated with high-risk antibiotics. To resolve this confounding effect and gain insights into antibiotics-masked microbiome signals …


Clinical Outcomes Of Immune Checkpoint Inhibitor Diabetes Mellitus At A Comprehensive Cancer Center, Rebecca Jeun, Priyanka C Iyer, Conor Best, Victor Lavis, Jeena M Varghese, Sireesha Yedururi, Veronica Brady, Isabella C Glitza Oliva, Ramona Dadu, Denai R Milton, Kristy Brock, Sonali Thosani Apr 2023

Clinical Outcomes Of Immune Checkpoint Inhibitor Diabetes Mellitus At A Comprehensive Cancer Center, Rebecca Jeun, Priyanka C Iyer, Conor Best, Victor Lavis, Jeena M Varghese, Sireesha Yedururi, Veronica Brady, Isabella C Glitza Oliva, Ramona Dadu, Denai R Milton, Kristy Brock, Sonali Thosani

Faculty, Staff and Student Publications

Introduction: Immune checkpoint inhibitor-associated diabetes mellitus (ICI-DM) is a rare adverse event. In this study, we characterize clinical outcomes of patients with ICI-DM and evaluate survival impact of this complication on melanoma patients.

Research design & methods: We conducted a retrospective review of 76 patients diagnosed with ICI-DM from April 2014 to December 2020.

Results: 68% of patients presented in diabetic ketoacidosis, 16% had readmissions for hyperglycemia, and hypoglycemia occurred in 70% of patients after diagnosis. Development of ICI-DM did not impact overall survival or progression-free survival in melanoma patients.

Conclusion: Development of ICI-DM is associated with long-term insulin dependence …


Co-Existing With Covid-19: Language Teacher Resiliency In Rural Schools, Kelly Moser, Tianlan Wei Apr 2023

Co-Existing With Covid-19: Language Teacher Resiliency In Rural Schools, Kelly Moser, Tianlan Wei

The Rural Educator

Language educators were unprepared for emergency remote language teaching (ERLT) due to lack of training in online pedagogy and negative perceptions of online instruction, and the rural community of language educators have been challenged in unique ways. Using the intersections of content (language teaching), space (rurality), and context (pandemic) as the theoretical framework, this comparative survey study aimed to investigate rural Mississippi language teachers’ beliefs and practices to ERLT in comparison to their counterparts nationwide. Two independent samples, one consisting of 94 Mississippi language teachers and the other consisting of 255 national K-12 language teachers, responded to our electronic survey …


Cell-Typing And Interaction Analysis Of The Immune Compartment Of The Tumor Microenvironment Using High-Resolution Omics Modalities, Courtney Taylor Schiebout Apr 2023

Cell-Typing And Interaction Analysis Of The Immune Compartment Of The Tumor Microenvironment Using High-Resolution Omics Modalities, Courtney Taylor Schiebout

Dartmouth College Ph.D Dissertations

Single-cell RNA-sequencing (scRNA-seq) has provided a new frontier for the investigation of complex tissues. One ideal candidate for the utilization of this method is the tumor microenvironment (TME). The TME is often host to a complex set of cell populations and behaviors that can be highly influential for cancer inhibition or progression. This is especially true of the immune compartment of the TME: the presence of certain types of immune cells in the TME and their expression profiles can significantly affect cancer prognosis in some cases. By providing individual cell-level gene expression data, scRNA-seq can be highly informative for characterizing …


Systematic Review And Pooled Analysis Of Randomized Controlled Trials In Countries Of The Gulf Cooperation Council (Gcc): Methods And Quality Assessment, Khalid S. Alraddadi, Fayzah H. Al-Adwani, Rajaa M. Al-Raddadi, Sultan H. Alamri, Iman K. Ramadan, Ahmad A. Mirza Apr 2023

Systematic Review And Pooled Analysis Of Randomized Controlled Trials In Countries Of The Gulf Cooperation Council (Gcc): Methods And Quality Assessment, Khalid S. Alraddadi, Fayzah H. Al-Adwani, Rajaa M. Al-Raddadi, Sultan H. Alamri, Iman K. Ramadan, Ahmad A. Mirza

Saudi Medical Journal

Objectives: To describe variations in characteristics of randomized controlled trials conducted in the Gulf Cooperation Council (GCC) countries, and critically appraising the quality of design, conduct and analysis of the trials. Methods: We carried out a systematically comprehensive electronic search of articles published between 1990 and 2018 and indexed in several databases: i) MEDLINE/PubMed, ii) EMBASE, iii) Cochrane Central Register of Controlled Trials (CENTRAL), iv) ClinicalTrials.gov, and v) World Health Organization International Clinical Trials Registry Platform. We summarized the overall risk of bias present in all analyzed studies using the Cochrane Collaboration risk of bias tool (CCRBT). Results: A remarkable …


Comment On: Prevalence Of Transfusion-Transmitted Infections In Saudi Arabia Blood Donors: A Nationwide, Cross-Sectional Study, Nour Al-Mozain, Maha A. Badawi, Mohammad A. Alfhili Apr 2023

Comment On: Prevalence Of Transfusion-Transmitted Infections In Saudi Arabia Blood Donors: A Nationwide, Cross-Sectional Study, Nour Al-Mozain, Maha A. Badawi, Mohammad A. Alfhili

Saudi Medical Journal

No abstract provided.


The Global Health Architecture: Governance And International Institutions To Advance Population Health Worldwide, Lawrence O. Gostin, Eric A. Friedman, Alexandra Finch Apr 2023

The Global Health Architecture: Governance And International Institutions To Advance Population Health Worldwide, Lawrence O. Gostin, Eric A. Friedman, Alexandra Finch

Georgetown Law Faculty Publications and Other Works

Policy Points Global health institutions and instruments should be reformed to fully incorporate the principles of good health governance: the right to health, equity, inclusive participation, transparency, accountability, and global solidarity. New legal instruments, like International Health Regulations amendments and the pandemic treaty, should be grounded in these principles of sound governance. Equity should be embedded into the prevention of, preparedness for, response to, and recovery from catastrophic health threats, within and across nations and sectors. This includes the extant model of charitable contributions for access to medical resources giving way to a new model that empowers low- and middle-income …


International Consensus Statement On Allergy And Rhinology: Allergic Rhinitis – 2023, Sarah K. Wise, Cecelia C. Damask, Lauren T. Roland, Charles Ebert, Joshua M. Levy, Sandra Lin, Amber Luong, Kenneth Rodriguez, Ahmad R. Sedaghat, Helene J. Krouse Apr 2023

International Consensus Statement On Allergy And Rhinology: Allergic Rhinitis – 2023, Sarah K. Wise, Cecelia C. Damask, Lauren T. Roland, Charles Ebert, Joshua M. Levy, Sandra Lin, Amber Luong, Kenneth Rodriguez, Ahmad R. Sedaghat, Helene J. Krouse

School of Medicine Publications

Background

In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document.

Methods

ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus …


Therapeutic Implications Of Uvb Irradiation In Cancer By Enhancing Anti-Tumor Immunity, Bilal B. Hafeez, Ed W. Alvarado, Dae Joon Kim Apr 2023

Therapeutic Implications Of Uvb Irradiation In Cancer By Enhancing Anti-Tumor Immunity, Bilal B. Hafeez, Ed W. Alvarado, Dae Joon Kim

School of Medicine Publications

UVB irradiation is well known for its impact in the development of skin cancer. However, low UVB irradiation plays protective role against various human diseases including cancer through its effect on tumor suppression. This article summarizes the key findings of the paper by Park et al., which describes a novel molecular mechanism of moderate UVB irradiation in suppressing the growth of melanoma and colorectal cancer. Key observations in this paper are that moderate UVB irradiation can enhance tumor immunity by 1) increased infiltration of CD4+ and CD8+ T cells, 2) increased infiltration of CD103+ conventional type 1 dendritic cells (cDC1), …


Effects Of Habitat Management On Rodent Diversity, Abundance, And Virus Infection Dynamics, Nathaniel Mull, Amy Schexnayder, Abigail Stolt, Tarja Sironen, Kristian M. Forbes Apr 2023

Effects Of Habitat Management On Rodent Diversity, Abundance, And Virus Infection Dynamics, Nathaniel Mull, Amy Schexnayder, Abigail Stolt, Tarja Sironen, Kristian M. Forbes

Biological Sciences Faculty Publications and Presentations

As anthropogenic factors continue to degrade natural areas, habitat management is needed to restore and maintain biodiversity. However, the impacts of different habitat management regimes on ecosystems have largely focused on vegetation analyses, with limited evaluation of downstream effects on wildlife. We compared the effects of grassland management regimes (prescribed burning, cutting/haying, or no active management) on rodent communities and the viruses they hosted. Rodents were trapped in 13 existing grassland sites in Northwest Arkansas, USA during 2020 and 2021. Rodent blood samples were screened for antibodies against three common rodent-borne virus groups: orthohantaviruses, arenaviruses, and orthopoxviruses. We captured 616 …


The Effectiveness Of Interventions That Support Penicillin Allergy Assessment And Delabeling Of Adult And Pediatric Patients By Nonallergy Specialists: A Systematic Review And Meta-Analysis, Neil Powell, Jennie Stephens, Declan Kohl, Rhys Owens, Shadia Ahmed, Crispin Musicha, Mathew Upton, Bridie Kent, Sarah Tonkin-Crine, Jonathan Sandoe Apr 2023

The Effectiveness Of Interventions That Support Penicillin Allergy Assessment And Delabeling Of Adult And Pediatric Patients By Nonallergy Specialists: A Systematic Review And Meta-Analysis, Neil Powell, Jennie Stephens, Declan Kohl, Rhys Owens, Shadia Ahmed, Crispin Musicha, Mathew Upton, Bridie Kent, Sarah Tonkin-Crine, Jonathan Sandoe

Peninsula Medical School

Objectives: Penicillin allergy records are often incorrect and may result in harm. We aimed to systematically review the effectiveness and safety of nonallergist health care worker delivery of penicillin allergy delabeling. Methods: We searched EMBASE/MEDLINE/CINAHL (Ovid), PsycInfo, Web of Science, and Cochrane CENTRAL from inception to January 21, 2022 and unpublished studies and gray literature. The proportion of patients allergic to penicillin delabeled and harmed was calculated using random-effects models. Results: Overall, 5019 patients were delabeled. Using allergy history alone, 14% (95% confidence interval [CI], 9-21%) of 4350 assessed patients were delabeled without reported harm. Direct drug provocation testing resulted …


How Technology May Be Used For Future Disease Prediction: A Systematic Literature Review, Rich P. Manprisio, Mohammed Salam Mar 2023

How Technology May Be Used For Future Disease Prediction: A Systematic Literature Review, Rich P. Manprisio, Mohammed Salam

Research Days

Exasperated by the current pandemic, our healthcare system continues to struggle with the accuracy and effectiveness of disease treatments. However, despite these growing challenges, technological advancements have aided potential disease prediction. There has been a positive correlation between utilizing technologies and leveraging them for disease predictions. Thanks to our continued reliance and technological advancement, current research shows that it has many viable options to aid the healthcare field. This systematic review looks at the current state of how technologies have been and can be used to improve healthcare.


Up-03 Identifying The Determinants Of Pediatric Vaccine Uptake During The Covid-19 Pandemic, Colleen Phan, Brandon Mercardo, Justin Travis Ph.D., Ginny Webb Ph.D. Mar 2023

Up-03 Identifying The Determinants Of Pediatric Vaccine Uptake During The Covid-19 Pandemic, Colleen Phan, Brandon Mercardo, Justin Travis Ph.D., Ginny Webb Ph.D.

SC Upstate Research Symposium

COVID-19 has caused over a million deaths in the United States. Preventative measures such as masks, social distancing, and vaccination have been implemented to fight against the disease. Unfortunately, a large subset of Americans opposed these efforts.

SC DHEC reports that as of January 2023, only 53.9 % of eligible South Carolinians have been fully vaccinated against COVID-19. Previous studies have shown vaccine hesitancy is influenced largely by personal concerns about vaccine development, peer vaccination status, and general skepticism of immunization.

Hesitancy towards pediatric vaccination is particularly concerning because unvaccinated children can act as vessels to exponentially accelerate COVID-19 transmission. …


The Community-Based Integrated Care System In The Context Of The Novel Coronavirus Disease (Covid-19) Pandemic, Koichi Asakura Mar 2023

The Community-Based Integrated Care System In The Context Of The Novel Coronavirus Disease (Covid-19) Pandemic, Koichi Asakura

Japanese Society and Culture

Abstract

Since the establishment of the Long-term Care Insurance System in 2000, the promotion of the Community-based Integrated Care System has been advocated in COVID-19 Pandemic. But "H30 Research Report on Community-based Integrated Care" expects mutual aid based on self-help, while accepting economic and health disparities on the ground of "inevitable disparities". We will discuss the Community-based Integrated Care System in the era of emerging viruses with a view to infectious disease pandemics such as the novel coronavirus pandemic in relation to the significance and prospects of ACP (Advance Care Planning).


Tailoring Of Neurosurgical Practice During Covid-19 In A Developing Country: Insights Gained And A Way Forward, Mustafa Mushtaq Husaain, Syeda Alisha Ali Zaida, Mujtaba Khalil, Muhammad Waqas Saeed Baqai, Altaf Ali Laghari, Muhammad Ehsan Bari Mar 2023

Tailoring Of Neurosurgical Practice During Covid-19 In A Developing Country: Insights Gained And A Way Forward, Mustafa Mushtaq Husaain, Syeda Alisha Ali Zaida, Mujtaba Khalil, Muhammad Waqas Saeed Baqai, Altaf Ali Laghari, Muhammad Ehsan Bari

Section of Neurosurgery

Background: The coronavirus disease-19 pandemic has aggravated the already neglected neurosurgical specialty in developing countries with a mounting shortage of specialists, long queues of operative patients, and a lack of adequate critical care units.
Methods: We have reviewed the innovative strategies adopted for maintaining an optimal surgical practice while ensuring team safety at the Aga Khan University Hospital, Karachi Pakistan.
Results: There is already a scarcity of resources in developing countries. The international guidelines had to be tailored to the context of the developing world. A multimodal strategy that focused on infection control, continuum of care, and the well-being of …


Pandemics And The Protection Of Privacy And Personal Information: Issues Concerning The Restriction On The Right To Privacy In Emergencies, Fumio Shimpo Mar 2023

Pandemics And The Protection Of Privacy And Personal Information: Issues Concerning The Restriction On The Right To Privacy In Emergencies, Fumio Shimpo

Japanese Society and Culture

This article focuses on issues which need to be considered in aiming to ensure both the effectiveness of infectious disease control measures and the protection of the right to privacy from the following perspectives.

(1) Issues regarding the restriction of the right to privacy in emergency situations, including (i) the types of measures taken in emergency situations and issues with respect to the restriction of the right to privacy in emergency situations, (ii) the normalisation, constancy and fixation of exceptional measures in emergency situations, (iii) dual-use and use for purposes different from those originally intended, (iv) acquisition of secondary information …


Occupational Safety And Health Practices Among Physical Therapists In Metro Manila During The Covid-19 Pandemic: A Qualitative Study Protocol, Zyra Mae V. Sicat, Paulin Grace M. Espino, Kristina B. Devora, Richard Lemuel Q. Budomo, Jewel Jace M. Abella, Barbara Nicole Y. Angeles, Giancarlo Philip H. Benzonan, Coby Jaleeyah Y. Chan, Erika L. Ignacio, Peter Oliver G. Palacio Jr., Julia Erin G. Tan Mar 2023

Occupational Safety And Health Practices Among Physical Therapists In Metro Manila During The Covid-19 Pandemic: A Qualitative Study Protocol, Zyra Mae V. Sicat, Paulin Grace M. Espino, Kristina B. Devora, Richard Lemuel Q. Budomo, Jewel Jace M. Abella, Barbara Nicole Y. Angeles, Giancarlo Philip H. Benzonan, Coby Jaleeyah Y. Chan, Erika L. Ignacio, Peter Oliver G. Palacio Jr., Julia Erin G. Tan

Philippine Journal of Physical Therapy

Introduction: The purpose of Occupational Safety and Health (OSH) is to protect and prevent workers from being exposed to risks and hazards that are detrimental to their health and safety. For the past two years, the coronavirus disease 2019 (COVID-19) is one of the most significant occupational health outcomes to physical therapists (PTs) due to the nature of their work. However, minimal studies have been conducted about the experiences and OSH practices of PTs during the pandemic. This study aims to understand the experiences of clinical PTs in Metro Manila, Philippines during the pandemic. The study also seeks to explore …


Experiences And Perspectives Of Filipino Patients With Stroke On Physical Therapy Telerehabilitation: A Phenomenological Study Protocol, Christopher G. Cruz, Donald S. Lipardo, Nicole Trizia S. Esplana, Beatrice Ann Q. Loa, Micah L. Dismaya, Janelle Meara Y. Lau, Mirzi Chelsea R. Quizzagan, Arianne B. Cardenas, Adellene Therese S. Celso, Hanz Lauren A. Taguinod, Kristian Joseph C. Martin, Leonardo S. Uy Iii Mar 2023

Experiences And Perspectives Of Filipino Patients With Stroke On Physical Therapy Telerehabilitation: A Phenomenological Study Protocol, Christopher G. Cruz, Donald S. Lipardo, Nicole Trizia S. Esplana, Beatrice Ann Q. Loa, Micah L. Dismaya, Janelle Meara Y. Lau, Mirzi Chelsea R. Quizzagan, Arianne B. Cardenas, Adellene Therese S. Celso, Hanz Lauren A. Taguinod, Kristian Joseph C. Martin, Leonardo S. Uy Iii

Philippine Journal of Physical Therapy

Introduction: Stroke is the third leading cause of death in the Philippines, so these patients must continuously undergo rehabilitation for faster recovery. With the rise of COVID-19, physical therapy (PT) telerehabilitation (TR) has emerged, where services are provided outside the usual rehabilitation setting for patients with stroke to continue their treatment while reducing the risk of acquiring COVID-19. However, it is a relatively new service in the country; hence, further research is needed to identify the factors and needs of these patients during TR, which may help improve PT TR services.

Objective: This study aims to explore the experiences …


Data-Driven Learning Algorithm Via Densely-Defined Multiplication Operators And Occupation Kernels., John Kyei Mar 2023

Data-Driven Learning Algorithm Via Densely-Defined Multiplication Operators And Occupation Kernels., John Kyei

USF Tampa Graduate Theses and Dissertations

Consider a nonautonomous nonlinear evolution $\dot{x}=f(x,t,\mu)$, where the vector $x(t) \in \mathbb{R}^n$ represents the state of the dynamical system at time $t$, $\mu$ contains system parameters, and $f(\cdot)$ represents a dynamic constraint. In most practical applications, the nonlinear dynamic constraint $f$ is unknown analytically. The problem of approximating $f$ directly from data measurements generated by the system is a main goal of this manuscript. In the postulates of the Nonlinear Autoregressive (NAR) framework, we show that the problem of approximating $f$ can be studied through symbols of densely defined multiplication operators over a Reproducing Kernel Hilbert Spaces (RKHS). In this …


Small Molecule Compounds, Active Ingredients Of Tcm, As Novel Therapeutics For Eosinophilic Esophagitis, Anish Maskey Mar 2023

Small Molecule Compounds, Active Ingredients Of Tcm, As Novel Therapeutics For Eosinophilic Esophagitis, Anish Maskey

NYMC Student Theses and Dissertations

Eosinophilic Esophagitis (EoE), a chronic inflammatory condition of the esophagus, characterized by esophageal dysfunction and eosinophilic inflammation. Current treatments for EoE include dietary elimination and swallowed steroids. Recently, Dupixent was approved for the treatment of EoE, but it has side effects such as eye inflammation and eczema. Traditional Chinese Medicine (TCM) practice has been used to improve GI symptoms in EoE patients. Two key active ingredients of a TCM formula, 7,4’-Dihydroxyflavone (DHF) and Berberine (BBR), have shown remarkable results in treating EoE.

To understand the role of two active ingredients in EoE, different experimental models were used. First, a computational …


Data Set: Themes In Health Sciences Librarianship Literature, 2016-2020: A Keyword And Subject Analysis, Shalu Gillum, Terri Gotschall, Pamela Herring, Deedra Walton, Natasha Williams, Nadine Dexter Mar 2023

Data Set: Themes In Health Sciences Librarianship Literature, 2016-2020: A Keyword And Subject Analysis, Shalu Gillum, Terri Gotschall, Pamela Herring, Deedra Walton, Natasha Williams, Nadine Dexter

Research Data and Datasets

Data set for Themes in Health Sciences Librarianship Literature, 2016-2020: A Keyword and Subject Analysis.


Strategies For Supporting Healthcare Workers’ Resilience And Mental Health During A Pandemic: A Scoping Review, Eka Oktavianto, I Made Moh. Yanuar Saifudin, Gani Apriningtyas Budiyati Mar 2023

Strategies For Supporting Healthcare Workers’ Resilience And Mental Health During A Pandemic: A Scoping Review, Eka Oktavianto, I Made Moh. Yanuar Saifudin, Gani Apriningtyas Budiyati

Jurnal Keperawatan Indonesia

As a group, health workers are at risk of experiencing stress and mental health problems at work, which may negatively affect their resilience. This study assessed the effectiveness of mental health support strategies for health workers during the COVID-19 pandemic. This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines in searching through three journal databases, such as: EBSCO, Scopus, and PubMed. The quality of the studies was assessed with the Crowe Critical Appraisal Tool, and the results of the review emerged from a process of synthesis that identified common themes. The search yielded five main …


Ethanol Extracts From Selected Tanzanian Medicinal Plants Selectively Inhibit Plasmodium Falciparum Growth In Vitro, Robert Christopher, Amina Msonga, Heinrich C. Hoppe, Fabrice F. Boyom Mar 2023

Ethanol Extracts From Selected Tanzanian Medicinal Plants Selectively Inhibit Plasmodium Falciparum Growth In Vitro, Robert Christopher, Amina Msonga, Heinrich C. Hoppe, Fabrice F. Boyom

Tanzania Journal of Science

This study aimed to assess the in vitro antiplasmodial and cytotoxic activities of ethanol extracts from the root barks, leaves and stem barks of seven medicinal plant species growing in Tanzania. The antiplasmodial activities of extracts against chloroquine-sensitive (3D7) and multidrug-resistant (Dd2) strains of Plasmodium falciparum were determined using a SYBR green I-based fluorescence assay, while the cytotoxicity of active extracts was determined against the human HepG2 cell line using a resazurin-based assay. Out of twenty-one extracts screened, two of them, namely, DFRE from Dracaena fragrans root bark (IC50Pf3D7 = 2.4 mg/mL) and EHSE from Erythrina haerdii stem bark (IC50Pf3D7 …


Penilaian Domain Pengkajian Paripurna Pasien Geriatri (P3g) Sebagai Faktor Yang Berpengaruh Terhadap Kejadian Pneumonia Nosokomial Pada Pasien Usia Lanjut Yang Dirawat Di Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, Hildebrand Hanoch Victor, Edy Rizal Wahyudi, C. Martin Rumende, C. H. Soejono, A. G. Rooshoeroe, Hamzah Shatri, Leonard Nainggolan, Cosphiadi Irawan Mar 2023

Penilaian Domain Pengkajian Paripurna Pasien Geriatri (P3g) Sebagai Faktor Yang Berpengaruh Terhadap Kejadian Pneumonia Nosokomial Pada Pasien Usia Lanjut Yang Dirawat Di Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, Hildebrand Hanoch Victor, Edy Rizal Wahyudi, C. Martin Rumende, C. H. Soejono, A. G. Rooshoeroe, Hamzah Shatri, Leonard Nainggolan, Cosphiadi Irawan

Jurnal Penyakit Dalam Indonesia

Introduction. Nosocomial pneumonia is a lung infection that occurs after the patient is hospitalized for more than 48 hours, without any signs of pulmonary infection at the time of treatment. When compared with young individuals, elderly individuals are more likely to have community-sourced and nosocomial infections with worse outcomes. Comprehensive Geriatric Assessment (CGA) domains are expected to explain the factors that contribute to nosocomial pneumonia in elderly patients. This study aimed to determine the proportion of elderly treated at Dr. Cipto Mangunkusumo National Central General Hospital who experienced nosocomial pneumonia and whether the CGA domains influence the occurrence of nosocomial …


Effects Of The Needle Exchange Program And Its Current Status In West Virginia, Thomas Norton, Amber Graves, Anthony Uriarte, Katherine Duty, Alberto Coustasse Mar 2023

Effects Of The Needle Exchange Program And Its Current Status In West Virginia, Thomas Norton, Amber Graves, Anthony Uriarte, Katherine Duty, Alberto Coustasse

Management Faculty Research

Excerpt:
One of the main problems that have impacted the state of healthcare in West Virginia has been the rising costs of treatments for bloodborne infections (Bates et al., 2019). Bloodborne pathogens and their resulting diseases have commonly spread by exchanging contaminated needles (Denault & Gardner, 2021). In West Virginia, Needle Exchange Programs (NEPs) have been implemented to reduce the transmission of certain infections, such as HIV, hepatitis B, and hepatitis C, which have been more common among drug users (Beck & Kersey, 2018). In 2015, West Virginia had the second-highest rate of cases of hepatitis C Virus (HCV) in …


A Forward Genetic Screen Identifies Genes Involved In Gametocyte Development Of The Human Malaria Parasite Plasmodium Falciparum., Jyotsna Chawla Mar 2023

A Forward Genetic Screen Identifies Genes Involved In Gametocyte Development Of The Human Malaria Parasite Plasmodium Falciparum., Jyotsna Chawla

USF Tampa Graduate Theses and Dissertations

Transmission of the deadly malaria parasite Plasmodium falciparum from human to mosquito is achieved by specialized intraerythrocytic sexual forms called gametocytes. Circulating in the vertebrate host, relatively few intraerythrocytic gametocytes are picked up during a bloodmeal to continue sexual development in the mosquito vector. Human-to-vector transmission thus represents an infection bottleneck in the parasite's life cycle for therapeutic interventions to prevent malaria. Though the crucial regulatory mechanisms leading to gametocyte commitment have recently come to light, networks of genes that control sexual development remain to be elucidated. Here, we report a forward genetic approach to identify genes associated with gametocyte …


Time And Temperature Stability Of Tritrichomonas Foetus In Phosphate-Buffered Saline As Evaluated By A Reverse Transcription Real-Time Pcr Assay And Field Analysis, Duan S. Loy, Renata Spuri Gomes, Enakshy Dutta, Bruce W. Brodersen, John Dustin Loy Mar 2023

Time And Temperature Stability Of Tritrichomonas Foetus In Phosphate-Buffered Saline As Evaluated By A Reverse Transcription Real-Time Pcr Assay And Field Analysis, Duan S. Loy, Renata Spuri Gomes, Enakshy Dutta, Bruce W. Brodersen, John Dustin Loy

School of Veterinary and Biomedical Sciences: Faculty Publications

Tritrichomonas foetus (TF) is a significant reproductive pathogen of cattle, and sample collection, handling, transport, and testing are significant hurdles to surveillance programs. Recent methods have been developed that allow for the direct detection of TF using a reverse transcription real-time PCR (direct RT-qPCR) approach. To evaluate these methods, a comparative analysis was conducted to assess the technical performance of this assay with a commercially available real- time PCR (qPCR) assay. In addition, the evaluation of two types of collection media (PBS and TF transport tube) was conducted that evaluated sample stability from 0 to 3 days when stored at …


Evaluation Of Free Radical Scavenging  Activity Of Sauce And Formulation Of Tamarindus Indica (L.) And Prunus Domestica (L.) Fruits, Zulnoreen Sarfaraz, Mehmooda Munazir, Mubashrah Munir, Asma Ahmed, Rehana Badar, Ayesha Tahir Mar 2023

Evaluation Of Free Radical Scavenging  Activity Of Sauce And Formulation Of Tamarindus Indica (L.) And Prunus Domestica (L.) Fruits, Zulnoreen Sarfaraz, Mehmooda Munazir, Mubashrah Munir, Asma Ahmed, Rehana Badar, Ayesha Tahir

Journal of Bioresource Management

The formulation and sauce of Tamarindus indica  (L.) and Prusnus  dometica (L.) are very popular recipes across globe. But, not even a single study existed on free-radical scavenging activity (FRSA) of afore-mentioned recipes. So, the present study was designed to bridge this gap of information. The FRSA of individual samples were also determined and compared with that of combinations of both. The highest value for FRSA among all samples was that of T. indica (158.9732 ± 12.658 % at 100 μg ml-1). It was followed by that of individual extract of P. domestica fruit (96.647 ± 0.554 %). …


Phenotypic Diversity Among Fennel (Foeniculum Vulgare) Germplasm Of Pakistan, Shumaila Khalil, Shazia Erum, Mahrine Rashid, Arifa Khan, Asif Javaid, Areej Abbasi, Irum Raza Mar 2023

Phenotypic Diversity Among Fennel (Foeniculum Vulgare) Germplasm Of Pakistan, Shumaila Khalil, Shazia Erum, Mahrine Rashid, Arifa Khan, Asif Javaid, Areej Abbasi, Irum Raza

Journal of Bioresource Management

Fennel is facing continuous challenge with reference to biotic and abiotic stresses that can be solved with the knowledge of available germplasm of fennel in the country or worldwide. Selection of fennel genotype on the basis of research interest can never been accomplished without gene pool. The aim of the present study was to explore the phenotypic diversity among selective fennel accession and identify lines having high yielding potential. In the present study thirty fennel accessions were sown in PGRI, NARC. Irrigation practice was carried out during the growing period. Data was recorded during different growth stages and after harvesting. …