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Sarcoidosis And Airway Disease After Immune Checkpoint Inhibitor Therapy: Case Study And Review Of The Literature, Felipe Soto, Luis F Torre-Sada, Frank E Mott, Sang T Kim, Roza Nurieva, Vickie R Shannon, Saadia A Faiz, Roberto F Casal, Mehmet Altan, Julie Lin, Ajay Sheshadri

Faculty, Staff and Student Publications

Pulmonary toxicity from immune checkpoint inhibitor therapy is typically a severe and potentially fatal complication, but these observations are driven by the most common toxicity, pneumonitis. Rarer pulmonary immune related adverse events, like airway disease and sarcoidosis, may have a more benign course. In this case report, we present a patient in whom therapy with the PD-1 inhibitor pembrolizumab resulted in severe eosinophilic asthma and sarcoidosis. This is the first case showing that anti-IL-5 inhibition may be safe in patients who develop eosinophilic asthma after ICI therapy. We further show that sarcoidosis does not necessarily require treatment cessation. This case …

Targeting Pd-L2-Rgmb Overcomes Microbiome-Related Immunotherapy Resistance, Joon Seok Park, Francesca S Gazzaniga, Meng Wu, Amalia K Luthens, Jacob Gillis, Wen Zheng, Martin W Lafleur, Sarah B Johnson, Golnaz Morad, Elizabeth M Park, Yifan Zhou, Stephanie S Watowich, Jennifer A Wargo, Gordon J Freeman, Dennis L Kasper, Arlene H Sharpe

Faculty, Staff and Student Publications

The gut microbiota is a crucial regulator of anti-tumour immunity during immune checkpoint inhibitor therapy. Several bacteria that promote an anti-tumour response to immune checkpoint inhibitors have been identified in mice1-6. Moreover, transplantation of faecal specimens from responders can improve the efficacy of anti-PD-1 therapy in patients with melanoma7,8. However, the increased efficacy from faecal transplants is variable and how gut bacteria promote anti-tumour immunity remains unclear. Here we show that the gut microbiome downregulates PD-L2 expression and its binding partner repulsive guidance molecule b (RGMb) to promote anti-tumour immunity and identify bacterial species that mediate this effect. PD-L1 and …

National Cancer Control Plan Of The Korea: Current Status And The Fourth Plan (2021-2025), Kyu-Tae Han, Jae Kwan Jun, Jeong-Soo Im

Faculty, Staff and Student Publications

Cancer management has become a major policy goal for the government of the Korea. As such, the government introduced the National Cancer Control Plan (NCCP) to reduce the individual and social burdens caused by cancer and to promote national health. During the past 25 years, 3 phases of the NCCP have been completed. During this time, the NCCP has changed significantly in all aspects of cancer control from prevention to survival. The targets for cancer control are increasing, and although some blind spots remain, new demands are emerging. The government initiated the fourth NCCP in March 2021, with the vision …

Pandemic Rendering The Transgender People More Vulnerable, As If It Was Not Already Enough: A Qualitative Exploration From Odisha, India, Prachi Parimita Rout, Ajitesh Mathur, Pranaya Kumar Swain

The Qualitative Report

The COVID-19 pandemic impacted people's livelihoods worldwide to an unprecedented magnitude, the most affected being the socially and economically disadvantaged and marginalized communities, including the transgender people that constitute one of the most vulnerable sections that are often subjected to discriminated in various sectors such as education, health, housing, and livelihood opportunities. The present study attempts to offer insights into the impact of the pandemic on the livelihood of transgender people in India, given that the pandemic adversely affected their primary sources of livelihood, such as begging, sex-work, singing, and dancing, due mainly to the restrictive measures: lockdown, shutdown, social/physical …

Klebsiella Aerogenes Adhesion Behaviour During Biofilm Formation On Monazite, Arya Van Alin, Melissa K. Corbett, Homayoun Fathollahzadeh, M. Christian Tjiam, Andrew Putnis, Jacques Eksteen, Anna H. Kaksonen, Elizabeth Watkin

Research outputs 2022 to 2026

The adsorption behaviour of micro-organisms during the initial attachment stage of biofilm formation affects subsequent stages. The available area for attachment and the chemophysical properties of a surface affect microbial attachment performance. This study focused on the initial attachment behaviour of Klebsiella aerogenes on monazite by measuring the ratio of planktonic against sessile subpopulations (P:S ratio), and the potential role of extracellular DNA (eDNA). eDNA production, effects of physicochemical properties of the surface, particle size, total available area for attachment, and the initial inoculation size on the attachment behaviour were tested. K. aerogenes attached to monazite immediately after exposure to …

Establishment Of A Transgenic Human Angiotensin Converting Enzyme-2 Hamster Infection Model For The Evaluation Of Therapeutics Against Severe Acute Respiratory Syndrome Coronavirus 2, Scott A. Gibson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The virus SARS-CoV-2 emerged in late 2019 and has gone on to spread throughout the global population. The virus is still the cause of a healthcare crisis two years after being identified. Viral infection in humans leads to the development of the disease COVID-19. A complex disease that can result in a wide variety of outcomes for infected individuals. In the majority of individuals, COVID-19 will manifest as either an asymptomatic disease state or a mild to moderate disease state that is resolved in approximately one week. In some infected patients COVID-19 will manifest with the rapid onset of severe …

Evaluating Methods For Pathogen Spillover Detection And Forecasting In Desert Bighorn Sheep (Ovis Canadensis Nelsoni), Grete E. Wilson-Henjum

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Managers mitigate the effects of disease on wildlife populations by detecting outbreaks and predicting disease transmission. Bighorn sheep (Ovis canadensis) populations face threat from the introduced pathogen Mycoplasma ovipneumoniae (M. ovipneumoniae). In the eastern Mojave Desert, managers detect pathogen outbreaks in desert bighorn (O. c. nelsoni) through aerial population surveys, which produce irregular and coarse population information. Furthermore, managers model the risk of M. ovipneumoniae transmission amongst desert bighorn populations, however these models assume that desert bighorn space use is unchanging across years. Here, I evaluate methods used by managers to detect disease outbreaks …

Utilizing Google Trends Data For Effective Modeling Of Covid-19 Outcomes: A Vector Auto Regression (Var) Approach, Gertrude Osei

Masters Theses and Doctoral Dissertations

Over the past decade, especially during the three-year COVID-19 epidemic, infodemiology, which uses web-based data for public health issues, has helped assess and anticipate human behavior. Google's real-time population data can indicate popular interest during a pandemic. This study analyzes Google Trends (GT) data of COVID-19-related search phrases and CDC information to forecast US daily new cases, cumulative cases, and deaths. Seasonality and trends are removed from trend data using an Augmented Dickey-Fuller (ADF) test. Using an eight-week forecast horizon, Granger Causality tests and Vector Auto Regression (VAR) models predict COVID-19 cases and deaths. GT's relative search volume of COVID-19 …

Assessment Of The Knowledge, Attitude, And Practice Towards Expired Drug Disposal Among The Community In Beirut City, Lebanon, Nada Khansa, Azza A. K. Gazy, Abdalla El-Lakany, Souraya Domiati

BAU Journal - Health and Wellbeing

The global increase in pharmaceutical spending has led to enhanced international awareness of the unused and expired drug issues due to improper drug disposal's harmful economic, environmental, and health effects. Consequently, the study was conducted to assess the knowledge, attitude, and practice toward expired drug disposal among the community in Beirut City, Lebanon. A cross-sectional, observational, questionnaire-based study was conducted. Data were analyzed using SPSS version 23. The fact that improper disposal of expired medicine affects the environment and health was acknowledged by 70.7% of the 450 participants. Even though 72.2% of the participants knew that the best method for …

Validation Of The Arabic Version Of The Food Safety And Hygiene Questionnaire Among Nutrition Student, Nada El Darra, Dina Cheaib, Leila Itani

BAU Journal - Health and Wellbeing

There is shortage of data on food safety knowledge and practices among Lebanese food handlers due to the lack of a reliable tool. The aim of the current study is to determine the reliability as well as the validity of an adopted Arabic version of the Osaili et al (2013) food safety questionnaire. Translation and back translation and testing equivalence were done using standard accepted procedures. A total of 110 undergraduate Nutrition and Dietetics students completed the questionnaire consisting of five subscales that covers major food safety concepts including personal hygiene, safe storage, cross contamination prevention, knowledge of health problems …

Community Pharmacists' Commitment To Preventive Measures During The Covid-19 Pandemic In Light Of The Economic Crisis In Beirut, Lebanon: A Simulated Client Study, Deema Rahme, Rania Itani, Samar Karout, Hani M. J. Khojah, Abdalla El-Lakany

BAU Journal - Health and Wellbeing

The burden on community pharmacists has dramatically increased since the COVID-19 pandemic, where the increased number of clients demands adhering to optimal infection protective measures. We aimed to investigate the level of adopted COVID-19 preventative measures by Lebanese community pharmacies and the influencing factors. One hundred community pharmacies in Beirut, were randomly selected and inspected by a simulated client. Signs of face-mask use, declaration of COVID-19 infection, and social distancing were observed in 62%, 48%, and 35% of pharmacies, respectively. Body temperature screening was absent. Only 20% of the pharmacies had limitations for the number of clients, and only 31% …

Review On Chemical Constituents And Biological Activities Of Genus Rumex, Rima Mohammad Kheir Boukhary, Zeina Omeiche, Mohamad Ali Hijazi, Priscilla Jawhari, Lyn Jawish, Hussein Ajjour, Maha Aboul Ela, Abdalla El-Lakany

BAU Journal - Health and Wellbeing

Genus Rumex belongs to the family Polygonaceae that is distributed worldwide and used in the treatment of different illnesses. Different parts of this plant are employed in the treatment of a number of ailments such as diarrhea, jaundice, hypertension, dermatopathy and inflammation. It was reported that they possess anti-oxidative, antimicrobial, antiviral and anti-cancer activities due to the presence of several phenolic constituents, anthraquinones and flavonoids such as rutin, luteolin and apigenin. Flavonoids play an important role against cardiovascular diseases by reducing oxidation of low-density lipoproteins. This article covers most of constituents of plants of genus Rumex reported from 2001 up …

Scalp, Oral, And Nail Pemphigus Vulgaris: Clinical Characteristics And A Review Of The Literature., Emily Eachus, Lauren E Delamielleure, Samrah Mitha, Taha F Rasul, Arfa Faiz

HPD Articles

Pemphigus vulgaris (PV) is a rare disease that affects the skin and mucous membranes, causing blistering and erosions. Identifying and effectively managing atypical presentations of pemphigus vulgaris can be challenging due to its rarity. We describe a 32-year-old male patient with a medical history including prediabetes, moderate asthma, hyperlipidemia, coccidioidomycosis, and respiratory infections. He was evaluated via telehealth in the allergy and immunology clinic for uncontrolled asthma. Initially, he complained of a whitish film in the mouth while on treatment with fluticasone and salmeterol. He also noted new vesicular lesions on his scalp and body. When evaluated later in the …

Hepatitis Screening, Kathryn Bland

Masters Theses/Capstone Projects

Project on hepatitis screening.

The Impact And Severity Of Non-Covid-19 Illnesses During Covid-19 Pandemic, Hanadi Alhammadi

Theses

The Covid-19 pandemic is a global crisis that occurred around the world and resulted in a large number of infections and deaths. As of September 2020, it was estimated that the Covid-19 pandemic had killed 976,000 people worldwide, healthcare facilities were burdened with containing this pandemic and made great efforts to treat and protect people, but in turn the focus on containing the pandemic led to many side effects, one of these effects is death from causes other than Covid-19. During the pandemic, people were afraid to visit hospitals to avoid contracting the COVID-19 virus, and hospitals were under great …

Dietary Determinants Of Stunting And Underweight In Under- Five Years Children In Pengasinan Health Center's (Puskesmas) Working Area, Depok, West Java, Muthia Syifa Rahmadina, Ratih Qamara Dewi, Arif Hidayat, Satria Yudistira, Fadila Wirawan

Indonesian Journal of Public Health Nutrition (IJPHN)

Stunting and underweight are public health problems, especially in under-five children. This study aims to explore the dietary determinants of stunting and underweight. Participants were 52 under-five children who visited Posyandu in Pengasinan and Bedahan, Depok. Body weight for age z-score (WAZ) and height for age z-score (HAZ) were measured with standardized measurement tools by trained operators. Questionnaires were administered to determine sociodemographic, maternal, and child health history, sanitation, disease history, and exclusive breastfeeding history. Data on food intake was obtained through the semi-quantitative Food Frequency Questionnaire and 24-hour recall. There was a significant correlation between the mother’s income with …

Health And Nutritional Status Among Internally Displaced Children Under Five Years, During The Civil War: Sri Lankan Experience, Madhuka Ambagahage

Indonesian Journal of Public Health Nutrition (IJPHN)

Around the globe, 1 in 6 children become vulnerable to grave physical and mental violence, hunger, sexual assaults, and exploitation of human rights due to war. These adversities are multi-dimensional, synergistic, and often subtle. This study attempted to evaluate the health and nutritional status of children aged under five years and living in the war zone of Sri Lanka, in view of improving the health services delivered to them. The study used a descriptive cross-sectional design. The study sample, 400, was based on probability proportionate and then systematic sampling drawn from IDP camps located in the Vavuniya district. Validated instruments …

Factors Related To The Incidence Of Diarrhea Of Children Aged 24-59 Months In Karangkamulyan Village, Cihara District, Lebak Regency In 2020, Hafshah Farah Fadhilah, Kusharisupeni Djokosujono, Ratu Ayu Dewi Sartika

Indonesian Journal of Public Health Nutrition (IJPHN)

Diarrhea remains a major issue in developing countries, including Indonesia, and is a leading cause of malnutrition and death. Banten is one of the provinces with a high incidence of diarrhea. In 2019, the district with the highest number of diarrhea cases for all ages in Banten was Lebak with a total of 50,270 cases. The age group with the greatest number of diarrhea cases was toddlers with over 14,000 cases. This study aimed to investigate the relationship between the incidence of diarrhea and the characteristics of toddlers and their parents, personal hygiene, and environmental sanitation. The study used secondary …

Dilema Pengalaman Informasi: Analisis Konseptual, Rusdan Kamil, Laksmi Laksmi

Jurnal Ilmu Informasi, Perpustakaan, dan Kearsipan

The information experience domain is a field of human information behavior research, concerned with one's engagement with sensory information using personal cognitive and affective experiences. The development of information technology and social media causes a flood of information which results in misinformation, disinformation, fake news, and hate speech in the public information space which increases personal distraction, this is also known as the phenomenon of information pathology. Another type of information pathology is the phenomenon of tensions in behavior and information practices presented as information experience dilemmas. This study aims to define, understand, and explain various forms of information experience …

Sars-Cov-2 Serostatus And Covid-19 Illness Characteristics By Variant Time Period In Non-Hospitalized Children And Adolescents, Sarah E Messiah, Michael D Swartz, Rhiana A Abbas, Yashar Talebi, Harold W Kohl, Melissa Valerio-Shewmaker, Stacia M Desantis, Ashraf Yaseen, Steven H Kelder, Jessica A Ross, Lindsay N Padilla, Michael O Gonzalez, Leqing Wu, David Lakey, Jennifer A Shuford, Stephen J Pont, Eric Boerwinkle

Faculty, Staff and Student Publications

OBJECTIVE: to describe COVID-19 illness characteristics, risk factors, and SARS-CoV-2 serostatus by variant time period in a large community-based pediatric sample.

DESIGN: Data were collected prospectively over four timepoints between October 2020 and November 2022 from a population-based cohort ages 5 to 19 years old.

SETTING: State of Texas, USA.

PARTICIPANTS: Participants ages 5 to 19 years were recruited from large pediatric healthcare systems, Federally Qualified Healthcare Centers, urban and rural clinical practices, health insurance providers, and a social media campaign.

EXPOSURE: SARS-CoV-2 infection.

MAIN OUTCOME(S) AND MEASURE(S): SARS-CoV-2 antibody status was assessed by the Roche Elecsys

RESULTS: Over half …

Prevalence Of Dog Heartworm (Dirofilaria Immitis) Infection In Invasive Aedes Aegypti And Aedes Albopictus Mosquitoes In Southern California, Irene Hui Ying Lee, Donghwi Kim, Romina Lee

Pacific Undergraduate Research and Creativity Conference (PURCC)

No abstract provided.

Unveiling The Emotional And Psychological States Of Instagram Users: A Deep Learning Approach To Mental Health Analysis, Muhammad K. Alabdly

Information Sciences Letters

People can now communicate with others who have common tastes to them and engage in conversation together while furthermore exchanging ideas, photos, and clips that convey their emotional states due to social media’s technology. As a consequence, there is an opportunity to investigate person sentiments and thoughts in social networking sites data in order to understand their viewpoints and sentiments when utilizing these digital platforms for interaction. Utilizing social network data to diagnose depression has gained extensive acceptance, there is still a number of unidentified characteristics. Due to its potential to shed light on the forecasting model, model complexity is …

Mawidi: Smart Appointments Booking System For Social Distancing, Dabiah Alboaneen, Fatimah Almohsin, Naba A. Almadan, Atheer Almarhoon

Information Sciences Letters

In traditional systems of banks, the booking process requires the client to be in the same place, the client withdraws a numbered paper from an electronic device and then sits in the waiting area until his/her number appears on the screen. However, these systems may cause many problems such as wasting clients’ time, overcrowding in the waiting area, slow workflow, etc. In this paper, a smart appointment booking system is developed to solve the problems of traditional booking systems of banks and achieve social distancing. The proposed system applies Quick Response (QR) code, Global Positioning System (GPS), and Bluetooth Low …

Effectiveness Of Counseling Program To Cope Withpsychosocial Effects Of Crises (Covid-19 Model), N. Ibrahim, M. Abd El-Meged

Information Sciences Letters

The current research aims to reveal the effectiveness of a counseling program to relieve the negative psychological and social effects created by the Covid-19 pandemic among a sample of female students at Al-Jouf University, by designing a counseling program based on psychological counseling techniques to mitigate these psychosocial repercussions. To achieve this goal, the researchers prepared a questionnaire on the psychological and social repercussions of the emerging coronavirus. The current research relied on the quasi-experimental approach with a one-group experimental design with pre- post- and, follow-up measurements to reveal the effectiveness of an indicative program which was applied to the …

Covid-19 Mathematical Study With Environmental Reservoir And Three General Functions For Transmissions, Shaimaa A. Azoz, K. M. Abdelhakim, Fatma Hussien

Information Sciences Letters

In this paper, the ongoing new coronavirus (COVID-19) epidemic is being investigated using a mathematical model. The model depicts the dynamics of infection with several transmission pathways and general infection functions, plus it highlights the significance of the environment as a reservoir for the disease’s propagation and dissemination. We have studied the qualitative behavior of the proposed model representing a system of fractional differential equations. Under a set of conditions on the general functions and the parameters, we have proven the global asymptotic stability of all steady states by using the Lyapunov method and LaSalle’s invariance principle. We also carried …

Analysis Of Psychological Symptoms Resulting From The Covid-19 Pandemic, R. M. Abdelrahman, A. F. Alsharif, N. R. Alsalhi

Information Sciences Letters

The present study aimed to investigate the level of severity of some psychological symptoms resulting from the Coronavirus pandemic, among a sample of Ajman University students in the United Arab Emirates, and to verify the differences between students’ demographic variables. The study used the descriptive-analytical approach and a modified DASS-21 scale, by adding the two scales of phobia and mental distraction to the tool. The reliability of the tool was verified for use on the sample in the current study. The most prominent results indicated that the highest psychological symptoms resulting from the Coronavirus pandemic were phobia (1.53 ± 0.98) …

The Juxtaposition Of Various Forms Of Cancer Vaccines For Metastatic Melanoma, Abby Molloy

Academic Festival

Cancer vaccines are a new, transcendent form of treatment aimed at achieving remission for metastatic melanoma patients. Recent studies have shown that two main forms of these vaccines have emerged: dendritic cell vaccines and personalized neoantigen vaccines. Neither of these types of cancer vaccines are especially effective for the treatment of metastatic melanoma on their own. However, they become much more efficient when utilized in conjunction other immunotherapeutic methods. Dendritic cell vaccines are most effective when used with either Ipilimumab or Interferon-α treatments. Personalized neoantigen vaccines are most productive when used with an anti-PD1 treatment. Each of these vaccines, when …

The Impact Of Suctioning Frequency On Rates Of Ventilator Associated Pneumonia, Sarah Gehrlein

Academic Festival

The purpose of this research is to evaluate the effectiveness of continuous and intermittent subglottic secretion drainage in mechanically ventilated patients on the prevention of ventilator associated pneumonia.

Rise In Vaccine Distrust As A Result Of The Covid-19 Pandemic, Katherine Sandt

Academic Festival

Since the Covid-19 pandemic began in 2020, there has been a decrease in vaccine administration due to the increased spread of misinformation and disinformation. This is a result of distrust in healthcare following the global pandemic. The spread of misinformation and disinformation in social media about the Covid-19 vaccine has caused parents to question routine childhood vaccines as well. This has increased the cases of viral outbreaks that could be prevented by vaccination and lead to reemergence of previously tamed viruses and an ultimate downfall in global health. These risks are preventable by spreading awareness of the problem of the …

Coronavirus Impact On Nursing, Hyzell Lim

Academic Festival

The health care system would not function efficiently as it does today if nurses were not present to perform their duties. Their role, became crucial and urgent come along the Coronavirus pandemic. The pandemic not only took a toll on the population, but nurses were also affected leading to many complications and challenges that require immediate intervention.