Digital Commons Network^™

A Reliable And Secure Mobile Cyber-Physical Digital Microfluidic Biochip For Intelligent Healthcare, Yinan Yao, Decheng Qiu, Huangda Liu, Zhongliao Yang, Ximeng Liu, Yang Yang, Chen Dong

Research Collection School Of Computing and Information Systems

Digital microfluidic, as an emerging and potential technology, diversifies the biochemical applications platform, such as protein dilution sewage detection. At present, a vast majority of universal cyberphysical digital microfluidic biochips (DMFBs) transmit data through wires via personal computers and microcontrollers (like Arduino), consequently, susceptible to various security threats and with the popularity of wireless devices, losing competitiveness gradually. On the premise that security be ensured first and foremost, calls for wireless portable, safe, and economical DMFBs are imperative to expand their application fields, engage more users, and cater to the trend of future wireless communication. To this end, a new …

Nurses’ Perceptions Of Ppe Compliance Among South Mississippi Medical- Surgical Nurses, Jenna Roush

Honors Theses

Utilizing Personal Protective Equipment (PPE) appropriately is critical in protecting nurses and patients from contracting infectious diseases. Poor compliance with PPE is associated with increased hospital-acquired infections and directly impacts infection control measures. This thesis delves into the perceptions of PPE compliance and awareness among medical-surgical nurses in South Mississippi. A quantitative study utilizing a 28-item survey was implemented. Likert-style and open-ended survey questions were completed by n=28 participants. Univariate analysis was used to determine compliance among each PPE item, awareness and confidence of PPE items, and whether there was a lack of training or a PPE shortage. Based on …

Human-Bat Interactions In A Disease Emergence Hotspot: Implications For Human Health And Bat Conservation, Reilly Tempest Jackson

Graduate Theses and Dissertations

Bats are an ecologically important taxon that can host zoonotic pathogens. Globally, many bat species are synanthropic and live closely with humans, often roosting in man-made structures. The spatial overlap between humans and bats creates opportunities for human-bat contact, which can lead to human exposure to bat-borne pathogens and conflicts that cause bat mortality. Despite this risk, little is known about the drivers and characteristics of these human-bat interactions in buildings and work is needed to understand this aspect of the wildlife-urban interface. In Chapter I, I present a literature review that identifies the geographic and taxonomic trends in reported …

Exploring The Mechanistic Effects Of Surface Characteristics On Uv254 And Bl405 Disinfection Efficacy, Castine Annastasia Bernardy

Doctoral Dissertations

The COVID-19 pandemic highlighted the need for more robust surface disinfection technologies. Photoinactivation efficacy for microbial pathogens and many surrogates has been well studied for water disinfection. However, there is a limited body of knowledge from research on surface disinfection applications of these technologies. The onset of the global pandemic resulted in a dramatic increase in surface disinfection devices being marketed to consumers, yet regulations for such devices have not been developed. This doctoral research studies the inactivation efficacy of two wavelengths, UV254 and BL405. The objective of this doctoral dissertation was to expand the body of knowledge required to …

Multivariate Analysis Approach To Factor-Affected Tuberculosis Disease, Zuli Agustina Gultom, Farid Akbar Siregar, Mahardika Abdi Prawira Tanjung, Al-Hamidy Hazidar

Knowledge Engineering and Data Science

Tuberculosis is a disease caused by infection with the mycobacterium tuberculosis complex. Tuberculosis attack organ besides the lung, such as the pleura, lining of the brain, lining of the heart, lymph gland, bones, joint, skin, intestines, kidney, urinary tract, and genital. This disease is found in densely populated settlements with poor sanitation, lack of ventilation and sunlight and lack of rest. Moreover, the factors that will be analyzed in this research are Population Density (X1), Number of HIV/AIDS (X2), number of toddlers who experience nutrition (X3), Number of toddlers who experience BCG immunization (X4), number of toddlers who get exclusive …

Assessing The Risk Of West Nile Virus In The Southwestern United States, Bradon Bucher

UNLV Theses, Dissertations, Professional Papers, and Capstones

Climate change is an increasing public health threat that has been shown to influence Culex mosquito populations, the vectors of West Nile Virus (WNV). The main objective of this study was to determine which variables are most associated with WNV in the Southwest United States, defined herein as: California, Nevada, Arizona, and Utah. A Poisson regression model was used to analyze total cases from 2004-2020 using the following predictors: mosquito season temperature average, mosquito season precipitation average, bodies of water, and protected lands. Results indicated that precipitation average (P =.014) and the interaction between precipitation and temperature (P=.024) were significant. …

Scalable Algorithm Design And Performance Analysis For Graph Motifs Discovery, Md Abdul Motaleb Faysal

UNLV Theses, Dissertations, Professional Papers, and Capstones

Discovering motifs or structural patterns, such as communities, is a significant graph application utilized for classifying groups in social and business networks, identifying similar proteins, detecting anomalous behavior in the cybersecurity domain, and finding critical entities in rumor propagation or infectious disease spreading. Existing state-of-the-art techniques for community discovery face challenges related to scalability, performance limitations, and methodological inaccuracies. The objective of this doctoral dissertation is to introduce novel parallel algorithms and propose high-performance computing architecture designs to address the performance constraints of current community detection approaches when processing large-scale social and biological data. This research focuses on two main …

Re: Incidence Of Sars-Cov-2 Breakthrough Infections After Vaccination In Adults: A Population-Based Survey Through 1 March 2023, Stacia M. Desantis, Ashraf Yaseen, Tianyao Hao, Luis Leon-Novelo, Yashar Talebi, Melissa A. Valerio-Shewmaker, Cesar L. Pinzon Gomez, Sarah E. Messiah, Harold W. Kohl, Steven H. Kelder, Jessica A. Ross, Lindsay N. Padilla, Mark Silberman, Samantha Wylie, David Lakey, Jennifer A. Shuford, Stephen J. Pont, Eric Boerwinkle, Michael D. Swartz

School of Medicine Faculty Publications and Presentations

Mycobacterium tuberculosis (Mtb) has latently infected over two billion people worldwide (LTBI) and caused ~1.6 million deaths in 2021. Human immunodeficiency virus (HIV) co-infection with Mtb will affect the Mtb progression and increase the risk of devel

Usage Statistics: Project Counter R5 Tr_J1 Report Fy2023 - Journal Requests (Excluding Oa_Gold) By Title, Andrée J. Rathemacher

Technical Services Reports and Statistics

Project COUNTER R5 Report TR_J1 for the University of Rhode Island for the period from July 1, 2022 - June 30, 2023. The TR_J1 report is defined as "Journal Requests (Excluding OA_Gold)." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.

File for download is Excel spreadsheet generated by Alma Analytics.

Results:

Total Item Requests - 836,365

Unique Item Requests - 625,288

Ecohiv-Infected Mice Show No Signs Of Platelet Activation, Hammodah Rawhi Hammodah Alfar, Dominic Ngima Nthenge-Ngumbau, Kathryn E. Saatman, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Platelets express several surface receptors that could interact with different viruses. To understand the mechanisms of HIV-1′s interaction with platelets, we chose the EcoHIV model. While EcoHIV is an established model for neuroAIDS, its effects on platelets are ill-defined. Our results indicate that EcoHIV behaves differently from HIV-1 and is cleared from circulation after 48 h post- infection. The EcoHIV course of infection resembles an HIV-1 infection under the effects of combined antiretroviral therapy (cART) since infected mice stayed immunocompetent and the virus was readily detected in the spleen. EcoHIV-infected mice failed to become thrombocytopenic and showed no signs of …

The Modified Clinical Progression Scale For Pediatric Patients: Evaluation As A Severity Metric And Outcome Measure In Severe Acute Viral Respiratory Illness., Shannon B. Leland, Steven J. Staffa, Margaret M. Newhams, Robinder G. Khemani, John C. Marshall, Cameron C. Young, Aline B. Maddux, Mark W. Hall, Scott L. Weiss, Adam J. Schwarz, Bria M. Coates, Ronald C. Sanders, Michele Kong, Neal J. Thomas, Ryan A. Nofziger, Melissa L. Cullimore, Natasha B. Halasa, Laura L. Loftis, Natalie Z. Cvijanovich, Jennifer E. Schuster, Heidi Flori, Shira J. Gertz, Janet R. Hume, Samantha M. Olson, Manish M. Patel, David Zurakowski, Adrienne G. Randolph, Pediatric Acute Lung And Sepsis Investigator’S Network Pediatric Intensive Care Influenza Study Group (Palisi Picflu) Investigators And Overcoming Covid-19 Investigators

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: To develop, evaluate, and explore the use of a pediatric ordinal score as a potential clinical trial outcome metric in children hospitalized with acute hypoxic respiratory failure caused by viral respiratory infections.

DESIGN: We modified the World Health Organization Clinical Progression Scale for pediatric patients (CPS-Ped) and assigned CPS-Ped at admission, days 2-4, 7, and 14. We identified predictors of clinical improvement (day 14 CPS-Ped ≤ 2 or a three-point decrease) using competing risks regression and compared clinical improvement to hospital length of stay (LOS) and ventilator-free days. We estimated sample sizes (80% power) to detect a 15% clinical …

Sars-Cov-2 Epidemiology And Covid-19 Mrna Vaccine Effectiveness Among Infants And Children Aged 6 Months-4 Years - New Vaccine Surveillance Network, United States, July 2022-September 2023., Ayzsa Tannis, Janet A. Englund, Ariana Perez, Elizabeth J. Harker, Mary Allen Staat, Elizabeth P. Schlaudecker, Natasha B. Halasa, Laura S. Stewart, John V. Williams, Marian G. Michaels, Rangaraj Selvarangan, Jennifer E. Schuster, Leila C. Sahni, Julie A. Boom, Geoffrey A. Weinberg, Peter G. Szilagyi, Benjamin R. Clopper, Yingtao Zhou, Meredith L. Mcmorrow, Eileen J. Klein, Heidi L. Moline

Manuscripts, Articles, Book Chapters and Other Papers

SARS-CoV-2 infection in young children is often mild or asymptomatic; however, some children are at risk for severe disease. Data describing the protective effectiveness of COVID-19 mRNA vaccines against COVID-19-associated emergency department (ED) visits and hospitalization in this population are limited. Data from the New Vaccine Surveillance Network, a prospective population-based surveillance system, were used to estimate vaccine effectiveness using a test-negative, case-control design and describe the epidemiology of SARS-CoV-2 in infants and children aged 6 months-4 years during July 1, 2022-September 30, 2023. Among 7,434 children included, 5% received a positive SARS-CoV-2 test result, and 95% received a negative …

Community Acquired Pneumonia Order Set Utilization Evaluation: A Retrospective Chart Review, Kristin Lytal Pharmd, Mspgx, Luke Keller Pharmd, Bcps, Bcccp, Blake Burton Pharmd, Bcps, Sarah Ferrell Pharmd, Bcpps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. December 2023.

This poster evaluated adherence of antimicrobial regimen selection using a community acquired pneumonia (CAP) order set updated to Infectious Disease Society of America/American Thoracic Society guidelines.

On The Origin And Evolution Of The Mosquito Male-Determining Factor Nix, James K. Biedler, Azedah Aryan, Yumin Qi, Aihua Wang, Ellen O. Martinson, Daniel A. Hartman, Fan Yang, Atashi Sharma, Katherine S. Morton, Mark Potters, Chujia Chen, Stephen L. Dobson, Gregory D. Ebel, Rebekah C. Kadling, Sally Paulson, Rui-De Xue, Michael R. Strand, Zhijian Tu

Entomology Faculty Publications

The mosquito family Culicidae is divided into 2 subfamilies named the Culicinae and Anophelinae. Nix, the dominant male-determining factor, has only been found in the culicines Aedes aegypti and Aedes albopictus, 2 important arboviral vectors that belong to the subgenus Stegomyia. Here we performed sex-specific whole-genome sequencing and RNAseq of divergent mosquito species and explored additional male-inclusive datasets to investigate the distribution of Nix. Except for the Culex genus, Nix homologs were found in all species surveyed from the Culicinae subfamily, including 12 additional species from 3 highly divergent tribes comprising 4 genera, suggesting Nix originated at least 133 to …

Using A Toxic Aging Coin To Assess Hexavalent Chromium-Induced Neurotoxicity., Samuel Thomas Vielee

Electronic Theses and Dissertations

We are facing an aging crisis, with 20% of the U.S. population projected to be geriatric (65+) by 2030 and live another 40+ years. Age-related diseases accompany a growing geriatric population, emphasizing the need to understand their etiology. Environmental pollutants compound this crisis by: 1) geriatrics are more susceptible, exacerbating age-related diseases and comorbidities, and 2) they accelerate biological aging, inducing age-related diseases at younger ages. We address this crisis using a ‘toxic aging coin’ approach; heads examines how age impacts toxicity, tails examines how chemicals accelerate aging. This thesis applies the heads side for Cr(VI)-induced neurotoxicity across ages. We …

The Experiences Of Leaders Who Transitioned To Leading A Virtual Team During The Covid-19 Pandemic: A Phenomenological Study., Jason W. Oliver

Electronic Theses and Dissertations

The COVID-19 pandemic led to organizations rapidly transitioning their workforces to virtual work settings. This sudden shift brought about many challenges to organizations and their employees. In this study, a phenomenological research approach was used to describe the lived experiences of leaders who transitioned to managing a virtual team during the COVID-19 pandemic. The study also explored how leaders adapted their leadership practices and leveraged people and technology when transitioning to managing a virtual team. The findings revealed seven themes that highlighted both benefits and challenges of virtual leadership and work. Leaders recognized the need for intentionality in their actions …

An Economic And Regulatory Analysis Of Gene Therapy Products Authorized By The Us Food And Drug Administration And The European Medicines Agency, Buthainah Ghanem

Pharmaceutical Sciences (PhD) Dissertations

Background: Gene therapy has recently emerged as an alternative for preventing and treating disease. Concerns have been expressed about the clinical value and the high cost of gene therapies.

Objective: This study assessed the authorization process of gene therapy products by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA), evaluated the post-marketing safety signals reported to the FDA Adverse Event Reporting System (FAERS), and assessed the cost-effectiveness analysis of three gene therapies axicabtagene ciloleucel(axi-cel), lisocabtagene maraleucel (liso-cel), and tisagenlecleucel (tisa-cel).

Research Design: For aim 1; data was collected using regulatory information from the FDA and the …

Characterizing The Regulation Of Candida Albicans Hyphal Morphogenesis In The Context Of Host Macrophages, Hannah Wilson

Dissertations and Theses (Open Access)

Candida albicans is a commensal fungus that resides on the skin, mucosal surfaces, and in the gut of an estimated 80% of individuals. Though generally harmless, C. albicans is capable of causing uncomfortable mucosal infections as well as deadly disseminated infections depending on the immune status of the host. Although antifungal therapeutics exist, the mortality rate associated with disseminated disease still lingers around 50%. Further, C. albicans is the fourth most common cause of all bloodstream infections and continues to present as a major clinical issue with less than satisfactory treatment options. For this reason, it is imperative to understand …

Issue 38

The Synapse: Intercollegiate science magazine

No abstract provided.

Phylogenomics Reveals The History Of Host Use In Mosquitoes, John Soghigan, Charles Sither, Silvia Andrade Justi, Gen Morinaga, Brian K. Cassel, Christopher J. Vitek, Todd P. Livdahl, Siyang Xia, Andrea Gloria-Soria, Jeffrey R. Powell, Thomas Zavortink, Christopher M. Hardy, Nathan D. Burkett-Cadena, Lawrence E. Reeves, Richard C. Wilkerson, Robert R. Dunn, David K. Yeates, Maria Anice Sallum, Brian D. Byrd, Michelle D. Trautwein, Yvonne-Marie Linton, Michael H. Reiskind, Brian M. Wiegmann

Biology

Mosquitoes have profoundly affected human history and continue to threaten human health through the transmission of a diverse array of pathogens. The phylogeny of mosquitoes has remained poorly characterized due to difficulty in taxonomic sampling and limited availability of genomic data beyond the most important vector species. Here, we used phylogenomic analysis of 709 single copy ortholog groups from 256 mosquito species to produce a strongly supported phylogeny that resolves the position of the major disease vector species and the major mosquito lineages. Our analyses support an origin of mosquitoes in the early Triassic (217 MYA [highest posterior density region: …

The Effects Of The Covid-19 Pandemic On Students In The School Setting: The Adaptations Needed For Tiered Supports, Eleni M. Gajewski

Dissertations

This study aims to evaluate the impact of the Covid-19 pandemic on students in the school setting and identify necessary adaptations needed, particularly through a tiered system of support. The research aims for two primary objectives by employing a constructivist framework utilizing mixed methods for data collection. Firstly, it aims to provide districts with a foundation for understanding the social-emotional and academic consequences of the pandemic on students. Secondly, its purpose is to empower districts to leverage this comprehensive evaluation as a proactive approach to cater to the diverse needs of all students. This includes responding to the challenges posed …

Penicillin Allergy Reassessment For Treatment Improvement (Part I): A Dental Office Tool To Support Appropriate Penicillin Allergy Labeling, Ashlyn J. Kunz Coyne, Dana Holger, Erinne Kennedy, Mackenzie Connell, Juliann Binienda, Christopher Giuliano, Elaine Bailey

Faculty and Staff Publications

Background

Dentists routinely review patient allergy histories and prescribe penicillin. Dental visits offer an opportunity to identify patient candidates for PCN allergy reassessment. Aim: to collect and evaluate clinician and patient feedback on a PCN Allergy Reassessment for Treatment Improvement (PARTI) tool created for patient-clinician communication about PCN allergy labels, and ultimately, to delabel patient EHR records, as appropriate.

Methods

A mixed methods pilot study was conducted January-March 2023. We administered a semi-quantitative questionnaire to interdisciplinary clinicians and performed semi-structured focus groups of patients with a PCN allergy label for tool feedback. The questionnaire and focus group guide were developed …

Burden Of Bradycardia And Barriers To Accessing Bradycardia Therapy In Underserved Countries, Diego Egas, Francisco Rodriguez, Aparna Jaswal, Jeilan Mohamed, Goran Milasinovic, Ahmed Al Fagih

Internal Medicine, East Africa

Bradycardia, a condition characterized by an abnormally slow heart rate, poses significant challenges in terms of diagnosis and treatment. While it is a concern world-wide, low- and middle-income countries (LMICs) face substantial barriers in accessing appropriate bradycardia therapy. This article aims to explore the global aetiology and incidence of bradycardia, compare the prevalence and management of the condition in high-income countries versus LMICs, identify the key reasons behind the disparities in access to bradycardia therapy in LMICs, and emphasize the urgent need to address these disparities to ensure equitable healthcare on a global scale

The Impact Of The Covid-19 Pandemic On The Well-Being Of People Incarcerated In United States Prisons, Kimberly Rivera

Department of Sociology: Dissertations, Theses, and Student Research

The COVID-19 pandemic has negatively impacted the population as a whole. However, the incarcerated population (which also experiences a variety of health disparities) has been disproportionately affected by the pandemic. Due to overcrowding, poor ventilation, and lack of resources, the incarcerated population already is at a heightened risk for negative health outcomes, made worse by the recent pandemic. To adapt to the rapidly changing conditions during the pandemic in 2020 and into 2022, new safety measures were implemented, but the unintended consequences associated with the implementation of these procedures have yet to be examined empirically. I conducted a qualitative content …

(R2059) Modeling The Spread Of Coronavirus With Self-Protection And Quarantine Effect, Dileep Sharma, Agraj Tripathi, Ram Naresh Tripathi

Applications and Applied Mathematics: An International Journal (AAM)

A nonlinear mathematical model to study the effect of transmission dynamics of COVID-19 virus in a population with variable size structure is proposed and analyzed. The model divides the total human population into five subclasses: susceptibles, self-protected susceptibles, infectives, quarantined infectives, and recovered population including a class representing cumulative density of coronavirus in the environmental reservoir. The model exhibits two equilibria, namely, the diseasefree and the endemic equilibrium. Model analysis reveals the global dynamics of the spread of COVID-19 is completely determined by the basic reproduction number. If basic reproduction number is greater than one, the endemic equilibrium is locally …

Reactive Oxygen Species Behaving Badly: Oxidized Phosphatidylcholines Corrupt Ca2+ Signaling In Airway Smooth Muscle, Deepak A. Deshpande, Raymond B. Penn

Center for Translational Medicine Faculty Papers

No abstract provided.

Immune Evasion And Membrane Fusion Of Sars-Cov-2 Xbb Subvariants Eg51 And Xbb23, Julia N Faraone, Panke Qu, Negin Goodarzi, Yi-Min Zheng, Claire Carlin, Linda J Saif, Eugene M Oltz, Kai Xu, Daniel Jones, Richard J Gumina, Shan-Lu Liu

Faculty, Staff and Student Publications

Immune evasion by SARS-CoV-2 paired with immune imprinting from monovalent mRNA vaccines has resulted in attenuated neutralizing antibody responses against Omicron subvariants. In this study, we characterized two new XBB variants rising in circulation - EG.5.1 and XBB.2.3, for their neutralization and syncytia formation. We determined the neutralizing antibody titers in sera of individuals that received a bivalent mRNA vaccine booster, BA.4/5-wave infection, or XBB.1.5-wave infection. Bivalent vaccination-induced antibodies neutralized ancestral D614G efficiently, but to a much less extent, two new EG.5.1 and XBB.2.3 variants. In fact, the enhanced neutralization escape of EG.5.1 appeared to be driven by its key …

Cognitive Task Analysis Of Clinicians’ Drug–Drug Interaction Management During Patient Care And Implications For Alert Design, Alissa L. Russ-Jara, Nervana Elkhadragy, Karen J. Arthur, Julie B. Dilulio, Laura G. Militello, Amanda P. Ifeachor, Peter A. Glassman, Alan J. Zillich, Michael Weiner

Purdue University Libraries Open Access Publishing Fund

Background Drug–drug interactions (DDIs) are common and can result in patient harm. Electronic health records warn clinicians about DDIs via alerts, but the clinical decision support they provide is inadequate. Little is known about clinicians’ real-world DDI decision-making process to inform more effective alerts.

Objective Apply cognitive task analysis techniques to determine informational cues used by clinicians to manage DDIs and identify opportunities to improve alerts.

Design Clinicians submitted incident forms involving DDIs, which were eligible for inclusion if there was potential for serious patient harm. For selected incidents, we met with the clinician for a 60 min interview. Each …

Comparison Of Microbial Respiratory Cultures Versus Mrsa Nasal Screen To Guide Vancomycin De-Escalation In Patients Hospitalized For Bacterial Pneumonia, Victoria E. Grusauskas, Anthony Wasielewski, Kristin Boyar

Nursing & Health Sciences Research Journal

Background: Methicillin-resistant Staphylococcus aureus (MRSA) nasal screen identifies the presence of MRSA nasal colonization, which can be used as a valuable antimicrobial stewardship tool to de-escalate empiric vancomycin therapy in patients with pneumonia. Current practices at a Florida hospital include using respiratory culture and MRSA nasal screening results to assist in treating MRSA pneumonia infections. This study aimed to evaluate the total duration of vancomycin therapy in patients with suspected MRSA respiratory tract infections. Methods: This was a single-center, retrospective chart review conducted at a tertiary medical center. Adult patients were assigned to either the respiratory culture-directed group or the …

Application Of Biochar For Antibiotic-Free Nutrient Recovery From Source-Separated Human Urine, Sayeda Ummeh Masrura

UNLV Theses, Dissertations, Professional Papers, and Capstones

In recent years, the application of biochar as a soil amendment has gained attention as a potential solution for nutrient management and environmental remediation. Biochar, a carbon-rich material produced through the pyrolysis of biomass under oxygen-limited conditions, exhibits unique physicochemical properties making it an effective sorbent for nutrients and contaminants. Its high surface area, porosity, and stability provide an ideal matrix for nutrient retention and release, as well as the immobilization of pollutants. One area of particular interest is the application of biochar for nutrient recovery from source-separated human urine. Source separation of urine has gained momentum as a sustainable …