Digital Commons Network^™

Multi-Omic Assessment Shows Dysregulation Of Pulmonary And Systemic Immunity To E-Cigarette Exposure, David P. Scieszka, Devon Garland, Russell Hunter, Guy Herbert, Selita Lucas, Yan Jin, Haiwei Gu, Matthew J. Campen, Judy L. Cannon

Pathology Research and Scholarship

Electronic cigarette (Ecig) use has become more common, gaining increasing acceptance as a safer alternative to tobacco smoking. However, the 2019 outbreak of Ecig and Vaping-Associated Lung Injury (EVALI) alerted the community to the potential for incorporation of deleterious ingredients such as vitamin E acetate into products without adequate safety testing. Understanding Ecig induced molecular changes in the lung and systemically can provide a path to safety assessment and protect consumers from unsafe formulations. While vitamin E acetate has been largely removed from commercial and illicit products, many Ecig products contain additives that remain largely uncharacterized. In this study, we …

The Impact Of Positive Thinking On Anxiety Level Of Corona Virus/ Covid-19 Infection During The Lockdown Among Unrwa Staff In Jordan, Wafa Sarhan, Ayman Qahwaji, Khawla Adarbeh

An-Najah University Journal for Research - B (Humanities)

The current study aimed to identify the impact of positive thinking on the anxiety of Coronavirus infection through the lockdown among UNRWA staff in Jordan. To achieve the objectives of the study, three measures were developed, the Positive Thinking Scale, the anxiety level of Coronavirus Infection Scale, and the lockdown Scale. A sample of (2036) employees responded to the measures. The results showed that the level of anxiety for COVID -19 infection among the sample was high, and statistically significant differences were found in the level of Covid-19 infection anxiety according to the sex variable for females, also statistically differences …

Assessing Recurrent Clostridioides Difficile Infections At Advocate Aurora Health Hospitals, Taylor Easey, Margaret Cook

Scientific Day

No abstract provided.

Tapped Twice: A Case Of A Rapidly Re-Accumulating Hepatic Hydrothorax In A Patient With Spontaneous Bacterial Empyema, Amir Khalil, Suma Alzouhayli, Silvia Novakova, Saad Shams, Ahmad Baiyasi, Maria Khalil, Mohammed Uddin, Aryan Shiari, Kareem Bazzy

The University of Louisville Journal of Respiratory Infections

Hepatic hydrothorax (HH) is a complication of decompensated liver cirrhosis that only occurs in about 5–6% of cirrhosis patients, defined as a pleural fluid in the setting of known liver disease, with the absence of any other cardiopulmonary etiology. Infected HH is a rare complication, designated as spontaneous bacterial empyema (SBEM), found in only 13–16% of patients with HH. This case follows a patient with SBEM who developed a recurrent pleural effusion minutes after thoracentesis. Our patient is a 56-year-old female with a history of alcoholic cirrhosis with pleuritic pain found to have right-sided pleural effusion with decompensation. She had …

Exploring The Potential Of Nanotechnology In Pediatric Healthcare: Advances, Challenges, And Future Directions., Hossein Omidian, Kwadwo Mfoafo

HPD Articles

The utilization of nanotechnology has brought about notable advancements in the field of pediatric medicine, providing novel approaches for drug delivery, disease diagnosis, and tissue engineering. Nanotechnology involves the manipulation of materials at the nanoscale, resulting in improved drug effectiveness and decreased toxicity. Numerous nanosystems, including nanoparticles, nanocapsules, and nanotubes, have been explored for their therapeutic potential in addressing pediatric diseases such as HIV, leukemia, and neuroblastoma. Nanotechnology has also shown promise in enhancing disease diagnosis accuracy, drug availability, and overcoming the blood-brain barrier obstacle in treating medulloblastoma. It is important to acknowledge that while nanotechnology offers significant opportunities, there …

Effects Of Climate Change On Human Health, Sara El Houzaly, Richa Gupta

Publications and Research

The effects of climate change are evident worldwide as average global land and air temperatures have been rising, glaciers and ice sheets are shrinking with the concomitant rise in sea levels, extreme weather events have become more frequent, and oceans are warming and acidifying. Humanity is facing a big environmental challenge which not only impacts our habitat but will also have ramifications on our health. The present review describes a detailed examination of the scientific evidence proving the relationship between climate change and various fatal human diseases in different geographical regions. Our findings indicate that variations in the patterns of …

Complications Associated With Lead Extraction In Device Related Infections: Analysis Of The National Inpatient Sample 2016-2019, Mouna Kodali, Ramtej Atluri, Ufuk Vardar, Sami Shoura, Sreeram Yalamanchili, Meghana Vallabhaneni

Scientific Day

No abstract provided.

An Unusual Cause Of Bacteremia In An Immunocompetent Child, Dana Nezon, Emily Keller

Scientific Day

No abstract provided.

A Case Of Mycobacterium Fortuitum On Standard Blood Culture, Kristen Kelly, Michael Tekippe, Emily Keller, Alison Hornyak

Scientific Day

No abstract provided.

Nurse-Led Research On The Impact Of Operating Room Traffic, Kimberly Mitchell, Peggy Kuehl, Mark Crucero, Stephanie Gore, Daniel Kufahl, Nathaniel Silgen, Tanja Ramich, Jessica Caamoan, Kaitlynn Houghton, Yunqi Liao, Mary Hook

Scientific Day

No abstract provided.

Atypical Presentation Of Purulent Bacterial Pericarditis, Valentina Turbay-Caballero, Christopher Para, Saira Ajmal

Scientific Day

No abstract provided.

Staphylococcal Spontaneous Mediastinal Abscess, Valentina Turbay-Caballero, Suyashi Singh, Saira Ajmal

Scientific Day

No abstract provided.

Transmission Of Mycobacterium Tuberculosis To Healthcare Personnel Resulting From Contaminated Bone Graft Material, United States, June 2021–August 2022, Ruoran Li, Molly Deutsch-Feldman, Tamasin Adams, Michelle Law, Chinpar Biak, Erika Pitcher, Marci Drees, Alfonso C Hernandez-Romieu, Thomas D Filardo, Tracina Cropper, Angelica Martinez, W Wyatt Wilson, Sandy P Althomsons, Sapna Bamrah Morris, Jonathan M Wortham, Isaac Benowitz, Noah G Schwartz, Kelly White, Maryam B Haddad, Janet B Glowicz, Bone Allograft Tuberculosis Investigators

Faculty, Staff and Student Publications

A nationwide tuberculosis outbreak linked to a viable bone allograft product contaminated with Mycobacterium tuberculosis was identified in June 2021. Our subsequent investigation identified 73 healthcare personnel with new latent tuberculosis infection following exposure to the contaminated product, product recipients, surgical instruments, or medical waste.

Impact Of The Covid-19 Pandemic On The Education And Procedural Volume Of Fellows In Critical Care Medicine – A Cross-Sectional Survey, Orlando Garner, Kanta Velamuri, Kristen Staggers, Andrea Barbara Braun

Faculty, Staff and Students Publications

BACKGROUND: The COVID-19 pandemic has changed the way medical education is delivered. The purpose of this study was to assess the impact of the COVID-19 pandemic on the education and procedural volume of critical care and pulmonary critical care fellows.

METHODS: We conducted a cross-sectional, internet-based, voluntary, anonymous, national survey of adult critical care fellows and academic attending physicians in critical care and pulmonary critical care fellowship programs in the United States between December 2020 and February 2021. Survey questions covered both didactic and non-didactic aspects of education and procedural volumes. Answers were ranked on a 5-point Likert scale. Survey …

Identification And Initial Characterization Of Hfq-Associated Srnas In Histophilus Somni Strain 2336, Bindu Subhadra, Dianjun Cao, Roderick Jensen, Clayton Caswell, Thomas J. Inzana

Faculty Publications - Biological Sciences

Small RNAs (sRNA), in association with the global chaperone regulator Hfq, positively or negatively regulate gene expression in bacteria. For this study, Histophilus somni sRNAs that bind to Hfq were identified and then partially characterized. The Hfq-associated sRNAs in H. somni were isolated and identified by co-immunoprecipitation using anti-Hfq antibody, followed by sRNA sequencing. Sequence analysis of the sRNA samples identified 100 putative sRNAs, out of which 16 were present in pathogenic strain 2336, but not in non-pathogenic strain 129Pt. Bioinformatic analyses suggested that the sRNAs HS9, HS79, and HS97 could bind to many genes putatively involved in virulence/biofilm formation. …

Emotional Responses To Covid-19 Stressors Increase Information Avoidance About An Important Unrelated Health Threat, Christopher Gustafson, Kate Brooks, Syed Imran Ali Meerza, Amalia Yiannaka

Department of Agricultural Economics: Faculty Publications

The COVID-19 pandemic, like other crises, has had direct and indirect impacts on individuals, many of which have been negative. While a large body of research has examined the impacts of COVID-19 on people’s lives, there is little evidence about how COVID-19 affects decision-making broadly. Emotional responses to COVID-19-related stressors, such as illness and income loss, provide a pathway for these stressors to affect decision-making. In this study, we examine linkages between exposure to COVID-19-related stressors—focusing on temporally specific local case counts and loss of income due to the pandemic—and decisions to access information about antimicrobial resistance (AMR), another critically …

Serological Prevalence Of Crimean–Congo Hemorrhagic Fever Virus Infection In Small Ruminants And Cattle In The Gambia, Jerusha Matthews, Arss Secka, David Scott Mcvey, Kimberly A. Dodd, Bonto Faburay

School of Veterinary and Biomedical Sciences: Faculty Publications

Crimean–Congo hemorrhagic fever virus (CCHFV) is a widely distributed tickborne zoonotic agent that infects a variety of host species. There is a lack of information on the true geographic distribution of the prevalence and risk of CCHFV in West Africa. A countrywide cross-sectional study involving 1413 extensively managed indigenous small ruminants and cattle at livestock sales markets and in village herds, respectively, was carried out in The Gambia. In sheep, an overall anti-CCHFV antibody prevalence of 18.9% (95% CI: 15.5–22.8%), goats 9.0% (95% CI: 6.7–11.7%), and cattle 59.9% (95% CI: 54.9–64.7%) was detected. Significant variation (p < 0.05) in the prevalence of anti-CCHFV antibodies at sites in the five administrative regions (sheep: 4.8–25.9%; goats: 1.8–17.1%) and three agroecological zones (sheep: 8.9–32.9%; goats: 4.1–18.0%) was also observed. Comparatively, higher anti-CCHFV antibody prevalence was detected in cattle (33.3–84.0%) compared to small ruminants (1.8–8.1%). This study represents the first countrywide investigation of the seroprevalence of CCHFV in The Gambia, and the results suggest potential circulation and endemicity of the virus in the country. These data provide critical information vital to the development of informed policies for the surveillance, diagnosis, and control of CCFHV infection in The Gambia and the region.

Megan Clement, Oral History Interview, 2023, You Li

Collective Memory of Women Journalists in COVID-19

Megan Clement from Montreuil, France, is a journalist, critic, and editor whose work focuses on gender equality, social policy, migration, human rights, arts, and culture. Her work has appeared in The Guardian, Bloomberg, The Sydney Morning Herald, Al Jazeera, The New Humanitarian, and News Deeply, among other publications.

Clement, an Australian journalist living in Paris, France at the time, traveled across three continents and underwent four quarantines for work and family reasons during the pandemic. She published her quarantine experiences in the first-person voice and raised public attention to the mismanagement of quarantine protocols at hotels and public housing. She …

Homegrown Stl 5th Annual Regional Summit On The State Of Opportunity For Black Boys And Young Men: Organizing For Solutions That Unleash The Elite Potential Of Young Black Males, Sean Joe, Maribeth Clifton, Demeisha Carlton-Brown

Center for Social Development Research

Convened annually, HomeGrown StL’s annual regional summit brings together service providers, government officials, private-sector partners, and residents to strengthen, align, and accelerate local collective-impact strategies that support the health, development, and economic mobility of Black boys and young men in St. Louis City and in St. Louis County.

This report summarizes developments from the 5th Regional Summit on the State of Opportunity for Black Boys and Young Men: Organizing for Solutions That Unleash the Elite Potential of Young Black Males, which convened June 9, 2022. In addition to describing Priority Objectives and Key Results developed during the summit, the report …

University Administrators’ Visions For The Recovery Of International Student Exchange In A Post–Covid-19 World, Yusuke Sakurai, Yukiko Ishikura, Ryoko Nakano, Yuki Nabeshima, Yu Sengoku, Akito Okada, Sachihiko Kondo

Higher Learning Research Communications

Objectives: Little is known about how international functions of higher education, such as exchange programmes, can be resumed during recovery from a disruptive global crisis, such as COVID-19. We collected the opinions of administrators of international exchange programmes regarding their plans to resume their exchange programmes in the recovery phase and identified variations in the responses concerning institution type (public vs. private) and the presence or absence of a medical school.

Method: We used multiple-choice survey questions in our study, resulting in 180 valid responses. We examined overall patterns using descriptive statistics and institutional uniqueness using Fisher’s exact test.

Results: …

Donepezil-Associated Survival Benefits Among Alzheimer’S Disease Patients Are Retained But Not Enhanced During Covid-19 Infections, Elizabeth A. Edmiston, Taissa A. Bej, Brigid Wilson, Robin L.P. Jump

Faculty Scholarship

Background and Aim: Donepezil is a front-line treatment for Alzheimer’s disease. Donepezil treatment is associated with decreased risk of all-cause mortality. Specific protection is observed in pneumonia and cardiovascular disease. We hypothesized that donepezil treatment would improve mortality among Alzheimer’s patients following infection with COVID-19. The objective of this study is to assess the influence of ongoing donepezil treatment on survival in Alzheimer’s disease patients after polymerase chain reaction (PCR)-confirmed COVID-19 infection. Methods: This is a retrospective cohort study. We conducted a national survey of Veterans with Alzheimer’s disease to assess the influence of ongoing donepezil treatment on survival in …

Universal Flu Vaccination May Soon Be A Reality, Amrit Ammanamanchi

URGENT Matters

No abstract provided.

Addressing Obsolescence In Fort Worth Public Pools: Enhancing Forest Park Public City Pool, Juan A. Fuentes

Landscape Architecture Masters & Design Theses - Archive

The city of Fort Worth, Texas has strived to ensure high-quality recreational water activities, which resulted in the closure or demolitions of several demolished aquatic parks in 2009. With many parks exceeding their lifespan, depicting functional and physical obsoleteness, and presenting health and safety risk to swimmers; the city, following the audit report, demolished famous aquatic parks, such as: Sycamore Pool, Hillside Park Lake, Como Park, Sylvania Park, Marine Creek Park, and Kellis Park, etc. In July 2008, Counsilman-Hunsaker conducted a city-wide Aquatic Master Plan to determine the future of the city's aquatic parks (Counsilman-Hunsaker, Inc.,2012). Implementation strategies included replacing …

Beclin-1-Dependent Autophagy, But Not Apoptosis, Is Critical For Stem-Cell-Mediated Endometrial Programming And The Establishment Of Pregnancy, Pooja Popli, Suni Tang, Sangappa B Chadchan, Chandni Talwar, Edmund B Rucker, Xiaoming Guan, Diana Monsivais, John P Lydon, Christina L Stallings, Kelle H Moley, Ramakrishna Kommagani

Faculty, Staff and Students Publications

The human endometrium shows a remarkable regenerative capacity that enables cyclical regeneration and remodeling throughout a woman's reproductive life. Although early postnatal uterine developmental cues direct this regeneration, the vital factors that govern early endometrial programming are largely unknown. We report that Beclin-1, an essential autophagy-associated protein, plays an integral role in uterine morphogenesis during the early postnatal period. We show that conditional depletion of Beclin-1 in the uterus triggers apoptosis and causes progressive loss of Lgr5+/Aldh1a1+ endometrial progenitor stem cells, with concomitant loss of Wnt signaling, which is crucial for stem cell renewal and epithelial gland development. Beclin-1 knockin …

Feral Swine As Indirect Indicators Of Environmental Anthrax Contamination And Potential Mechanical Vectors Of Infectious Spores, Rachel M. Maison, Maggie R. Priore, Vienna R. Brown, Michael Bodenchuk, Bradley R. Borlee, Richard Bowen, Angela M. Bosco-Lauth

United States Department of Agriculture Wildlife Services: Staff Publications

U.S. government work

Trends Over 20 Years Of Antimicrobial Prophylaxis For Artificial Urinary Sphincter Surgery, Helen H. Sun, Michael Callegari, Eric Zhou, Erin Jesse, Megan Prunty, Jonathan E. Shoag, Kyle Scarberry, Kirtishri Mishra, Shubham Gupta

Faculty Scholarship

Introduction and Objective: Perioperative antimicrobial prophylaxis is crucial for prevention of prosthesis and patient morbidity after artificial urinary sphincter (AUS) placement. While antibiotic guidelines exist for many urologic procedures, adoption patterns for AUS surgery are unclear. We aimed to assess trends in antibiotic prophylaxis for AUS and outcomes relative to American Urological Association (AUA) Best Practice guidelines. Methods: The Premier Healthcare Database was queried from 2000 to 2020. Encounters involving AUS insertion, revision/removal, and associated complications were identified via ICD and CPT codes. Premier charge codes were used to identify antibiotics used during the insertion encounter. AUS‐related complication events were …

Facilitators And Barriers To Effective Scale-Up Of Evidence-Based Nonprofit-Level Hiv Prevention And Treatment Interventions Among Black Men Who Have Sex With Men (Msm), Ugochukwu C. Uzoeghelu

Master's Projects and Capstones

Since the scale-up of HIV/AIDS prevention evidence-based interventions (EBIs) has not been simple in nonprofit settings, it is crucial to examine processes that occur in the translation of the EBIs into practice that affect successful implementation through the lens of nonprofit principles and practices. This paper examines the facilitators and barriers to effective scale-up of evidence-based HIV prevention and treatment services for nonprofit health organizations that serve Black men who have sex with men (MSM). I interviewed nonprofit health organizations (n = 4) engaged in the global response to end the HIV epidemic, specifically those who provide HIV prevention and …

Hiv Treatment Utilization: An Exploration Of One Ryan White Clinic, Joseph Powe

MUSC Theses and Dissertations

According to the findings of recent research, the HIV epidemic is still an active problem all over the world. Some racial and ethnic groups have a significantly higher likelihood of contracting HIV, even though many efforts have been made at all levels of government, from the municipal to the federal, to raise public awareness of the recognized risk. There are two focal points for the HIV epidemic. While prevention is essential, infected patients must also be encouraged to continue treatment to accomplish viral suppression and delay the onset of AIDS. When we look more deeply at a local Ryan White …

Impact Of The Covid-19 Pandemic On Stress And Burnout Related Experiences Of The Infection Preventionists In The Greater Houston Area, Tawanna Mcinnis-Cole

MUSC Theses and Dissertations

Objective: With many studies revealing that the pandemic created stress and burnout for physicians and nurses, these same stressors could have created mental and emotional challenges for the Infection Prevention staff at healthcare institutions. Efforts are needed to better understand the stress, anxiety, and burnout-related experiences that the pandemic created for these team members who worked in the greater Houston area between March 2020-September 2022.

Methods: This qualitative study used focus group sessions to obtain data. Two sessions were held in person and two sessions were hosted virtually. All sessions were audio recorded and transcribed. The transcripts were coded using …

The Role Of Complement In Stroke And Traumatic Brain Injury, Christine Couch

MUSC Theses and Dissertations

Brain and neural injury are a non-specific disease category that includes traumatic brain injury (TBI) and stroke. Both TBI and stroke are common, costly, and leading causes of severe disability in adults. Both stroke and TBI are responsible for substantial disability in working age adults, with stroke being the second leading cause of death worldwide [1] and TBI a major cause of disability in people younger than their 40's [2]. The immune response after brain injury is multifactorial and involves both local and systemic events at the cellular and molecular level. The complement system is a component of both the …