Digital Commons Network^™

Inflammatory Biomarkers Associated With Brain Mri Measures: Framingham Heart Study Offspring Cohort, Jiachen Chen, Margaret Doyle, Yuan Fang, Ahmed A. Y. Ragab, Joanne Murabito, Kathryn Lunetta

Pharmacy Faculty Scholarship

Brain MRI volumes measuring brain atrophy have been associated with risks for Alzheimer’s Disease (AD) and related dementia. Inflammatory biomarkers associated with brain MRI volumes may provide insight into the neuroinflammation associated with these diseases. The study aim is to identify circulating inflammatory biomarkers associated with total and regional brain MRI volumes in the Framingham Heart Study Offspring cohort. Participants (N=662, 52% female, mean age 62 years) free of dementia and stroke at the time of blood draw and who had MRI measures within five years were profiled using the OLINK Proteomics inflammation panel. Pairwise cross-sectional associations between 68 biomarkers …

Vol.51 N.22 December 21, 2023, Voice Media Ventures

Black Voice News

No abstract provided.

Barriers, Motivation, And Interventions For Women With Substance Use Disorders During Pregnancy, Sarah Novinska

Counselor Education Capstones

Pregnant women with a substance use disorder have many barriers to treatment, including stigma, fear of disclosing use, the potential for having their children taken away, gender and race disparities, mental health, public policy, and the lengthy process to get into treatment. Ways to overcome these barriers, including gender-specific treatment, decreasing stigma associated with substance use disorders, increasing trauma informed care, providers assessing their own biases, and changing public policy are discussed. In addition, the importance of learning how to overcome barriers to protect the health of mothers, babies, their families, and communities, along with several interventions including screening and …

The Contemporary Tax Journal Volume 12, No. 2 – Winter 2023

The Contemporary Tax Journal

No abstract provided.

Examining Psychology Majors: Perceptions, Motivations, & Goals, Madison Wetherell

Honors Program Theses and Projects

While psychology is one of the United States’ most popular undergraduate majors, we face a shortage of mental health workers which has created a lack of access to quality care. A gap exists between students’ interest in psychology as an academic subject and their interest in mental health careers. Using quantitative survey data from psychology majors in a required orientational course, this study assessed why students major in psychology, their feelings about the psychology major, and their post-graduate plans. Many psychology majors reported wanting to help others, which was associated with wanting a psychology-related career. Students of color reported a …

Clemson Commencement Program, December 2023, Clemson University

Clemson Commencement Programs

No abstract provided.

Peer Mentoring Program For Psychology Major Students: A Promising Prospect, Nadia Calderon

Honors Program Theses and Projects

Many first-year and second-year undergraduate students face challenges and abundance of college resources they may not know how to use. Learning about campus resources and dealing with these challenges could help students thrive academically and personally in the college environment. We gathered survey data from 87 students from seven sections of the Bridgewater State University Orientation to the Psychology Major (OPM) course. In one of these sections, we implemented a Peer Mentoring Program (PMP). We also hosted psychology-focused events in which 48 psychology major students attended and filled out feedback questionnaires. In this study we aimed to analyze the effectiveness …

Romancing The University: Bipoc Scholars In Romance Novels In The 1980s And Now, Jayashree Kamble

Publications and Research

English-language mass-market romance novels written by BIPOC (Black, Indigenous, and People of Color) writers and starring BIPOC protagonists are a small but important group. This article is a comparative analysis of how recent representations of diversity in this sub-set of the genre, specifically the character of the Black academic and the language of racial justice, compare with the first group of BIPOC novels that were published in 1984 (Sandra Kitt’s Adam and Eva and All Good Things as well as Barbara Stephens’s A Toast to Love). In Adrianna Herrera’s American Love Story (2019), Katrina Jackson’s Office Hours (2020), and …

“This Person Is Safe”: An Exemplar Of Conducting Individual Interviews In Qualitative Research With Black Women, Quenette Walton, Olulbunmi Oyewuwo, Other Co-Authors

Social Work Faculty Publications

Significant conceptual and empirical evidence has been found through qualitative research about the benefits, limitations, and uses of individual interviews. However, there is scant research illustrating how researchers use specific techniques that center participants’ intersecting identities to build rapport, trust, and authentic connections during individual interviews, and especially during interviews with Black women. We illustrate how we used eight empirically grounded techniques in our qualitative individual interviews with Black women. Through our analysis of the interviews, the concept of safety emerged. “This person is safe” reflects the combined stories the women reported regarding their experiences engaging in individual interviews. In …

Simvastatin In Critically Ill Patients With Covid-19, Thomas E Hills, Elizabeth Lorenzi, Lindsay R Berry, Murali Shyamsundar, Farah Al-Beidh, Djillali Annane, Yaseen Arabi, Diptesh Aryal, Carly Au, Abigail Beane, Zahra Bhimani, Marc Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Aidan Burrell, Meredith Buxton, Carolyn S Calfee, Maurizio Cecconi, Allen C Cheng, Matthew E Cove, Michelle A Detry, Lise J Estcourt, Mark Fitzgerald, Ewan C Goligher, Herman Goossens, Cameron Green, Rashan Haniffa, David A Harrison, Madiha Hashmi, Alisa M Higgins, Christopher Horvat, David T Huang, Nao Ichihara, Deva Jayakumar, Peter S Kruger, François Lamontagne, Lamprini Lampro, Patrick R Lawler, John C Marshall, Alexina J Mason, Anna Mcglothlin, Shay Mcguinness, Zoe K Mcquilten, Bryan J Mcverry, Paul R Mouncey, Srinivas Murthy, Matthew D Neal, Alistair D Nichol, Cecilia M O'Kane, Rachael L Parke, Jane C Parker, Ebenezer Rabindrarajan, Luis F Reyes, Kathryn M Rowan, Hiroki Saito, Marlene Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Pratik Sinha, B Taylor Thompson, Alexis F Turgeon, Anne M Turner, Frank Van De Veerdonk, Sebastian Weis, Ian S Young, Ryan Zarychanski, Roger J Lewis, Colin J Mcarthur, Derek C Angus, Scott M Berry, Lennie P G Derde, Steve A Webb, Anthony C Gordon, Daniel F Mcauley

Faculty, Staff and Student Publications

BACKGROUND: The efficacy of simvastatin in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.

METHODS: In an ongoing international, multifactorial, adaptive platform, randomized, controlled trial, we evaluated simvastatin (80 mg daily) as compared with no statin (control) in critically ill patients with Covid-19 who were not receiving statins at baseline. The primary outcome was respiratory and cardiovascular organ support-free days, assessed on an ordinal scale combining in-hospital death (assigned a value of -1) and days free of organ support through day 21 in survivors; the analyis used a Bayesian hierarchical ordinal model. The adaptive design included prespecified statistical …

A Mega-Study Of Stereotypes And Attitudes Toward Nationality Groups In The United States, Ayse Selin Toprakkiran

Arts & Sciences Graduate Student Theses and Dissertations

The culture and demographics of the United States have been greatly influenced by numerous immigrant nationality groups, which continue to play a vital role in society. To understand how nationality groups are perceived in the United States, we asked residents to report stereotypes and attitudes toward 28 nationality groups and 6 racial/ethnic groups (N = 7,050). Our findings showed various patterns across 15 stereotypes, grouped under warmth, status, Americanness, and political orientation dimensions. Warmth-related stereotypes and attitudes varied widely across groups and did not follow a discernible pattern. Status-related stereotypes of Asian Americans and East Asian nationality groups were consistently …

Long Oligodeoxynucleotides: Chemical Synthesis, Isolation Via Catching-By-Polymerization, Verification Via Sequencing, And Gene Expression Demonstration, Yipeng Yin, Reed Arneson, Alexander Apostle, Adikari M.D.N. Eriyagama, Komal Chillar, Emily Burke, Martina Jahfetson, Yinan Yuan, Shiyue Fang

Michigan Tech Publications

Long oligodeoxynucleotides (ODNs) are segments of DNAs having over one hundred nucleotides (nt). They are typically assembled using enzymatic methods such as PCR and ligation from shorter 20 to 60 nt ODNs produced by automated de novo chemical synthesis. While these methods have made many projects in areas such as synthetic biology and protein engineering possible, they have various drawbacks. For example, they cannot produce genes and genomes with long repeats and have difficulty to produce sequences containing stable secondary structures. Here, we report a direct de novo chemical synthesis of 400 nt ODNs, and their isolation from the complex …

The Involvement Of Hepatic Cytochrome P450s In The Cytotoxicity Of Lapatinib, Si Chen, Xilin Li, Yuxi Li, Xiaobo He, Matthew Bryant, Xuan Qin, Feng Li, Ji-Eun Seo, Xiaoqing Guo, Nan Mei, Lei Guo

Faculty, Staff and Students Publications

Lapatinib, an oral tyrosine kinase inhibitor used as a first-line treatment for HER2-positive breast cancer, has been reported to be associated with hepatotoxicity; however, the underlying mechanisms remain unclear. In this study, we report that lapatinib causes cytotoxicity in multiple types of hepatic cells, including primary human hepatocytes, HepaRG cells, and HepG2 cells. A 24-h treatment with lapatinib induced cell cycle disturbances, apoptosis, and DNA damage, and decreased the protein levels of topoisomerase in HepG2 cells. We investigated the role of cytochrome P450 (CYP)-mediated metabolism in lapatinib-induced cytotoxicity using our previously established HepG2 cell lines, which express each of 14 …

Promoting Community Identity Through Repurposing Vacant Land: City Park Design In Downtown Arlington, Dasom Phoebe Mun

Landscape Architecture Masters & Design Theses - Archive

As urbanization progressed rapidly in the mid-nineteenth century, people moved to cities for many reasons, and as a consequence, the volume of green spaces in the cities was reduced. Lands have been developed or redeveloped as urbanization developed. In this process, leftover spaces and vacant lands have been created. Urban vacant lands could be a problem for many cities. They might have aesthetic issues such as disordered or cluttered appearances, safety issues due to lack of maintenance, economic issues for it being wasted and so on (Kim et al., 2023). However, vacant lands in urban areas have become suitable assets …

Evaluating The Performance Of Real Estate Exchange-Traded Funds, Davinder K. Malhotra

School of Business Faculty Papers

This study examines the net monthly returns of real estate exchange-traded funds (ETFs) through various performance evaluation models and market situations. The results reveal that these ETFs generated positive alphas and outperformed benchmark indices in absolute returns. However, their performance varied across market conditions, demonstrating both outperformance and underperformance compared to U.S. and global stocks. During the COVID-19 pandemic, real estate ETFs displayed a decline, trailing behind U.S. and global equities in both absolute returns and risk-adjusted performance. This emphasized their vulnerability during economic crises. Utilizing the Carhart four-factor model, significant exposure of real estate ETFs to the stock market …

Validating Osteological Correlates For The Hepatic Piston In The American Alligator (Alligator Mississippiensis), Clinton A. Grand Pre, William Thielicke, Raul E. Diaz, Brandon P. Hedrick, Ruth M. Elsey, Emma R. Schachner

School of Graduate Studies Faculty Publications

Unlike the majority of sauropsids, which breathe primarily through costal and abdominal muscle contractions, extant crocodilians have evolved the hepatic piston pump, a unique additional ventilatory mechanism powered by the diaphragmaticus muscle. This muscle originates from the bony pelvis, wrapping around the abdominal viscera, extending cranially to the liver. The liver then attaches to the caudal margin of the lungs, resulting in a sub-fusiform morphology for the entire ‘‘pulmo-hepatic-diaphragmatic’’ structure. When the diaphragmaticus muscle contracts during inspiration, the liver is pulled caudally, lowering pressure in the thoracolumbar cavity, and inflating the lungs. It has been established that the hepatic piston …

Aversion Properties Of Retrorsine, Retrorsine Nitrogen Oxide And Frosted Senecio Latifolius, Leendert D. Snyman

Poisonous Plant Research (PPR)

Two pilot trials, investigating the aversive properties of retrorsine and retrorsine nitrogen oxide and that of frosted Senecio latifolius, were executed. Retrorsine and retrorsine-NO (the toxic principles of Senecio retrorsus), unlke sceleratine-NO (the toxic principle of another hepatotoxic pyrrolizidine alkaloid containing plant, namely S. latifolius), were not capable of establishing aversion when given to a sheep. Frosted S. latifolius given to a sheep also did not induce aversion. However, a sheep averted to S. latifolius (non-frosted) refused eating frosted S. latifolius.

Folate Deficiency Modifies The Risk Of Cin3+ Associated With Dna Methylation Levels: A Nested Case–Control Study From The Ascus-Col Trial, María C. Agudelo, Samuel Agudelo, Attila Lorincz, Arianis Tatiana Ramírez, Kelly Melisa Castañeda, Isabel Garcés-Palacio, Arnold H. Zea, Chandrika Piyathilake, Gloria Ines Sanchez

School of Medicine Faculty Publications

Purpose: To our knowledge, there are very few studies evaluating if the levels of folate modify the risk of cervical intraepithelial neoplasia grade 2 and higher (CIN2+ and CIN3+) associated with the levels of HPV genome methylation, two cofactors related to single carbon metabolism and independently associated with cervical cancer in previous studies. We conducted a case–control study nested in a three-arm randomized clinical pragmatic trial (ASCUS-COL trial) to evaluate the risk of CIN3+ associated with methylation levels according to serum folate concentrations. Methods: Cases (n = 155) were women with histologically confirmed CIN2+ (113 CIN2, 38 CIN3, and 4 …

Efficacy And Safety Of Teprotumumab In Patients With Thyroid Eye Disease Of Long Duration And Low Disease Activity, Raymond S Douglas, Steven Couch, Sara T Wester, Brian T Fowler, Catherine Y Liu, Prem S Subramanian, Rosa Tang, Quang T Nguyen, Robi N Maamari, Shoaib Ugradar, Kate Hsu, Michael Karon, Marius N Stan

2020-Current year OA Pubs

CONTEXT: Early inflammatory thyroid eye disease (TED) can lead to symptomatic chronic disease, including disabling proptosis. Teprotumumab, an insulin-like growth factor-1 receptor (IGF-1R) inhibitor, previously demonstrated efficacy in acute, high-inflammation TED trials.

OBJECTIVE: We present data from the first placebo-controlled trial with teprotumumab in chronic/low disease activity TED.

METHODS: This randomized double-masked, placebo-controlled trial, conducted at 11 US centers, enrolled adult participants with TED duration of 2 to 10 years, Clinical Activity Score (CAS) ≤ 1 or no additional inflammation or progression in proptosis/diplopia for ≥1 year, proptosis ≥3 mm from before TED and/or from normal, euthyroid/mildly hypo/hyperthyroid, no prior …

Pharmacokinetics Of Dacarbazine And Unesbulin And Cyp1a2-Mediated Drug Interactions In Patients With Leiomyosarcoma, Lan Gao, Diksha Kaushik, Brian A Van Tine, Matthew A Ingham, Steven Attia, Christian F Meyer, Gary K Schwartz, Pius Maliakal, John D Baird, Jiyuan Ma, Rosemary Barrett, Dhiren D'Silva, Kylie O'Keefe, Ronald Kong

2020-Current year OA Pubs

Unesbulin is being investigated in combination with dacarbazine (DTIC) as a potential therapeutic agent in patients with advanced leiomyosarcoma (LMS). This paper reports the pharmacokinetics (PK) of unesbulin, DTIC, and its unreactive surrogate metabolite 5-aminoimidazole-4-carboxamide (AIC) in 29 patients with advanced LMS. Drug interactions between DTIC (and AIC) and unesbulin were evaluated. DTIC (1000 mg/m

Dsm-5 Conduct Disorder And Symptoms In Youths At High Risk Of Psychosis In Kenya With Dsm-5 Mental Disorders And Substance Use: Towards Integrated Management, David M Ndetei, Victoria Mutiso, Christine Musyimi, Reinpeter Momanyi, Pascalyne Nyamai, Peter Tyrer, Daniel Mamah

2020-Current year OA Pubs

Little is known about the prevalence of Conduct Disorder (CD) and symptoms of CD in high risk psychosis persons at both clinical and community populations in LMICs and in particular Kenya. This study aimed to document (1) the prevalence of CD diagnosis and symptoms in youth who screened positive for psychosis and (2) the associated mental disorders and substance use in the same cohort in LMIC. The sample size was 536 students who had screened positive on the Washington Early Recognition Center Affectivity and Psychosis (WERCAP) from a population of 9,742 high school, college and university students, but had not …

Annual Financial Report Tipton County, Tennessee For The Year Ended June 30, 2023, Tennessee. Comptroller Of The Treasury.

Tennessee County Audit Reports

No abstract provided.

Annual Financial Report Williamson County, Tennessee For The Year Ended June 30, 2023, Tennessee. Comptroller Of The Treasury.

Tennessee County Audit Reports

No abstract provided.

Cabozantinib Plus Atezolizumab In Previously Untreated Advanced Hepatocellular Carcinoma And Previously Treated Gastric Cancer And Gastroesophageal Junction Adenocarcinoma: Results From Two Expansion Cohorts Of A Multicentre, Open-Label, Phase 1b Trial (Cosmic-021)., Daneng Li, Yohann Loriot, Adam Burgoyne, James Cleary, Armando Santoro, Daniel Lin, Santiago Ponce Aix, Ignacio Garrido-Laguna, Ramu Sudhagoni, Xiang Guo, Svetlana Andrianova, Scott Paulson

Kimmel Cancer Center Faculty Papers

BACKGROUND: Cabozantinib is approved for previously treated advanced hepatocellular carcinoma (aHCC) and has been investigated in gastric cancer (GC) and gastroesophageal junction adenocarcinoma (GEJ). Atezolizumab plus bevacizumab is approved for unresectable or metastatic HCC untreated with prior systemic therapy. We evaluated efficacy and safety of cabozantinib plus atezolizumab in aHCC previously untreated with systemic anticancer therapy or previously treated GC/GEJ.

METHODS: COSMIC-021 (ClinicalTrials.gov, NCT03170960) is an open-label, phase 1b study in solid tumours with a dose-escalation stage followed by tumour-specific expansion cohorts, including aHCC (cohort 14) and GC/GEJ (cohort 15). Eligible patients were aged ≥18 years with measurable locally advanced, …

Exploring Attitudes Toward “Sugar Relationships” Across 87 Countries: A Global Perspective On Exchanges Of Resources For Sex And Companionship, Norbert Meskó, Marta Kowal, András Láng, Ferenc Kocsor, Szabolcs A. Bandi, Adam Putz, Piotr Sorokowski, David A. Frederick, Felipe E. García, Leonardo A. Aguilar, Anna Studzinska, Chee Seng Tan, Biljana Gjoneska, Taciano L. Milfont, Bulut M Topcu, Dmitry Grigoryev, Toivo Aavik, Mahmoud Boussena, Alan D.A. Mattiassi, Reza Afhami, Rizwana Amin, Roberto Baiocco, Hamdaoui Brahim, Ali R. Can, Joao Carneiro, Hakan Çetinkaya, Dimitri Chubinidze, Eliane Deschrijver, Yahya Don, Dmitrii Dubrov, Izzet Duyar, Marija Jovic, Julia A. Kamburidis, Farah Khan, Hareesol Khun-Inkeeree, Maida Koso-Drljevic, David Lacko, Karlijn Massar, Mara Morelli, Jean C. Natividade, Ellen K. Nyhus, Ju Hee Park, Farid Pazhoohi, Ekaterine Pirtskhalava, Koen Ponnet, Pavol Prokop, Dušana Šakan, Singha Tulyakul, Austin H. Wang, Sibele D. Aquino, Derya D. Atamtürk, Nana Burduli, Antonio Chirumbolo, Seda Dural, Edgardo Etchezahar, Moharrampour N Ghahraman, Balazs Aczel, Luca Kozma, Samuel Lins, Efisio Manunta, Tiago Marot, Moises Mebarak, Kirill G. Miroshnik, Katarina Misetic, Marietta Papadatou-Pastou, Bence Bakos, Fatima Zahra Sahli, Sangeeta Singh, Çağlar Solak, Tatiana Volkodav, Anna Wlodarczyk, Grace Akello, Marios Argyrides, Ogeday Çoker, Katarzyna Galasinska, Yepes T Gómez, Aleksander Kobylarek, Miguel Landa-Blanco, Marlon Mayorga, Barış Özener, Ma Criselda T. Pacquing, Marc Eric S. Reyes, Ayşegül Şahin, William Tamayo-Agudelo, Gulmira Topanova, N/A Toplu-Demir

School of Psychology

The current study investigates attitudes toward one form of sex for resources: the so-called sugar relationships, which often involve exchanges of resources for sex and/or companionship. The present study examined associations among attitudes toward sugar relationships and relevant variables (e.g., sex, sociosexuality, gender inequality, parasitic exposure) in 69,924 participants across 87 countries. Two self-report measures of Acceptance of Sugar Relationships (ASR) developed for younger companion providers (ASR-YWMS) and older resource providers (ASR-OMWS) were translated into 37 languages. We tested cross-sex and cross-linguistic construct equivalence, cross-cultural invariance in sex differences, and the importance of the hypothetical predictors of ASR. Both measures …

The Ninth Amendment: The "Hard Problem" Of U.S. Constitutional Law, Jorge M. Farinacci Fernós

Journal Articles

Like with the mythical lamp that can grant any three wishes, federal courts in the United States have buried the Ninth Amendment of the U.S. Constitution deep within the sands of American law in order to avoid coming to terms with its potential regarding the protection of unenumerated constitutional rights. Courts have been able to do so, in part, because of the seemingly impossible task of extracting from the text and history of the Ninth Amendment sufficient elements needed to identify which unenumerated rights may be subject to judicial enforcement.

This impossibility is an illusion and is contrary to the …

Evaluation Of Electrical Grid Resilience Based On Φλεπ Metrics And Integration Of A Nuclear Power Plant, Abdulla Darwish Alblooshi

Theses

This study analyzes electrical grid resilience, the evaluation methods, and resilience metrics, as well as the impact of a nuclear power plant as a base-load supplier on the resilience of an electrical grid during extreme events such as high-speed winds or hurricanes. The case study was implemented on a 10-generator 39-bus system (New England) using PowerWorld, and the data extraction and plotting were performed using MATLAB. The wind speeds, fragility curves, and time-to-restore function were randomly created based on previous models, and their values were extracted from MATLAB calculation using randomly generated but uniformly distributed wind speeds. The resilience metrics …

Harm Reduction In Undergraduate And Graduate Medical Education: A Systematic Scoping Review, Kelsey R. Smith, Nina K. Shah, Abby L. Adamczyk, Lara C. Weinstein, Erin L. Kelly

Department of Family & Community Medicine Faculty Papers

BACKGROUND: Substance use increasingly contributes to early morbidity and mortality, which necessitates greater preparation of the healthcare workforce to mitigate its harm. The purpose of this systematic scoping review is to: 1) review published curricula on harm reduction for substance use implemented by undergraduate (UME) and graduate medical education (GME) in the United States and Canada, 2) develop a framework to describe a comprehensive approach to harm reduction medical education, and 3) propose additional content topics for future consideration.

METHODS: PubMed, Scopus, ERIC: Education Resources Information Center (Ovid), and MedEdPORTAL were searched. Studies included any English language curricula about harm …

The Relationship Of Mental Health With Learning Achievement In Adolescent, Muhammad Zulfikri Mukarom, Weslei Daeli

Cities and Urban Development Journal

Background: Mental health is not yet considered important in some countries. The most common mental health disorder in teenagers is depression. This research aims to determine whether there is a relationship between mental health and academic achievement in adolescents. When mental disorders occur, there will be problems with attention and concentration, health problems, difficulty understanding the material and motivation to learn will also decrease, affecting grades or achievement at school.

Aims: This research aims to determine whether there is a relationship between mental health and academic achievement in adolescents.

Methods: The mental health measuring tool uses SRQ-29 (Self reporting Questionnaire …

Dwelling Quality Assessment During Covid-19 Pandemic Self Isolation In East Jakarta, Aisyah Arimurti Afandi

Cities and Urban Development Journal

Background: The government encouraged public health protection with self isolation policy as an effort to control Covid-19 on a wide scale and prevent an increase in occupation rate on health service facilities in order to quickly and effectively handling confirmed cases of Covid-19. Dwelling quality is a significant factor to ensure that self isolation can be carried out effectively since it is stated in public health theory that one of the factors that influences

a person's health status is dwelling quality.

Aims: This research aims to assess dwelling quality where self-isolation being carried out during Covid-19 in East Jakarta. …