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Gender Career Stereotypes, Implicit Bias, And Occupational Therapy, Laura H. Vanpuymbrouck, Carli Friedman

Journal of Occupational Therapy Education

Implicit (unconscious) gender bias and stereotypes can affect clinical decisions and interactions between healthcare professionals, as well as impact careers. However, there is no research exploring the implicit gender bias or stereotypes of occupational therapy students or practitioners. Therefore, the aim of this study was to examine the gender-career bias of occupational therapy students. To do so, occupational therapy students (n = 54) from three Midwestern United States graduate occupational therapy programs completed the gender-career attitudes implicit association test (IAT) – biases associating women with family, and men with career – as well as a survey polling demographic information. …

Applying An Anti-Racist Pedagogy To Develop And Deliver A Racial Microaggressions Workshop For Occupational Therapy Students, Shannon Giannitsopoulou, Jane A. Davis, Bismah Khalid, Ruheena Sangrar

Journal of Occupational Therapy Education

Many workshops about identifying, understanding, and responding to microaggressions have been designed and delivered to learners within health education. However, few workshops implement an anti-racist pedagogical approach, and none presented in the literature have been created specifically for occupational therapy students. Anti-racist pedagogical approaches explicitly link interpersonal and institutional/structural oppressions to ensure that the impacts of microaggressions are not minimized by focusing solely on interpersonal interactions. A specific workshop is needed to address the noted persistence of racial microaggressions directed at clients, families, students, and practitioners within occupational therapy contexts and due to the embeddedness of practitioners in clients’ daily …

Modulation Of Tlr4/Nf-Κb, Nrf2/Ho-1 And Pi3k/Akt Signaling By Cilostazol Mitigates Lipopolysaccharide-Induced Septic Acute Kidney Injury, Ahmed F. Mohamed Dr., Helmy Said Dr, Hala F. Zaki, Marwa M. Safar Prof. Dr.

Pharmacy

Aim: Cilostazol was investigated as a protective agent against lipopolysaccharide (LPS)-associated acute kidney damage in mice. Methods: Cilostazol (50 mg/kg/day; p.o.) administered for 7 consecutive days before a single LPS dose (2 mg/kg; i.p.). Results: Cilostazol hampered serum creatinine, cystatin C, and renal kidney injury molecule-1 and neutrophil gelatinase associated lipocalin; repressed toll-like receptor 4 and MyD88 transcription, as well as nuclear factor-kappa B p65, interleukin-1b, and malondialdehyde content; and boosted Nrf2 mRNA expression, hemeoxygenase-1 activity, and reduced glutathione content. This was synchronous with an upregulation of p-phosphoinositide 3-kinase and p-Akt expressions. Conclusion: Collectively, cilostazol prevented LPS renal injury, which …

Modulation Of Tlr4/Nf- Modulation Of Tlr4/Nf-Κb, Nrf2/Ho-1 And Pi3k/Akt Signaling By Cilostazol Mitigates Lipopolysaccharide-Induced Septic Acute Kidney Injury, Ahmed F. Mohamed, Helmy M. Sayed, Hala F. Zaki, Marwa Safar

Pharmacy

Aim: Cilostazol was investigated as a protective agent against lipopolysaccharide (LPS)-associated acute kidney damage in mice. Methods: Cilostazol (50 mg/kg/day; p.o.) administered for 7 consecutive days before a single LPS dose (2 mg/kg; i.p.). Results: Cilostazol hampered serum creatinine, cystatin C, and renal kidney injury molecule-1 and neutrophil gelatinaseassociated lipocalin; repressed toll-like receptor 4 and MyD88 transcription, as well as nuclear factor-kappa B p65, interleukin-1b, and malondialdehyde content; and boosted Nrf2 mRNA expression, hemeoxygenase-1 activity, and reduced glutathione content. This was synchronous with an upregulation of p-phosphoinositide 3-kinase and p-Akt expressions. Conclusion: Collectively, cilostazol prevented LPS renal injury, which might …

Nanoghosts For Therapeutic Applications, Ekram Hany Mohamed, Abdel-Mottaleb, Mohamed S. S. Attia

Pharmacy

This chapter illustrates the significance of nanotechnology and new therapeutic formulations based on nanoparticles to improve the efficacy of cargos intended for treating various diseases and disorders. Various strategies were explored to stabilize and equip these therapeutic nanoformulations with the capability to escape the human immune system and enhance the targeted delivery of the cargos to diseased tissues for different biomedical applications including therapeutic, theranostic, imaging, and sensing purposes. Synthetic and natural approaches were widely investigated and it was found that the natural approach employing membranes from different types of human cells to camouflage the nanoparticles or cargos via coating …

Marine-Based Candidates As Potential Rsk1 Inhibitors: A Computational Study, Amgad Albohy, Mousa Altarabeen, Peter Proksch, Qosay Al-Balas, Werner Ernst Georg Müller

Pharmacy

Manzamines are chemically related compounds extracted from the methanolic extract of Acanthostrongylophora ingens species. Seven compounds were identified by our research group and are being characterized. As their biological target is unknown, this work is based on previous screening work performed by Mayer et al., who revealed that manzamine A could be an inhibitor of RSK1 kinase. Within this work, the RSK1 N-terminal kinase domain is exploited as a target for our work and the seven compounds are docked using Autodock Vina software. The results show that one of the most active compounds, Manzamine A N-oxide (5), with an IC50 …

A Guardian For Justice: The Women's Commission At Emu, Mary-Elizabeth B. Murphy

Faculty Scholarship 2023

No abstract provided.

On The Outside Looking In: Difficulties In Obtaining The Opinions Of Muslim Religious Leaders’ Views On Domestic Violence Experienced By Married Muslim Women, Muhammed Suleman Dr

The Qualitative Report

In this paper I discuss the difficulties I faced in getting access to respondents in a qualitative study on the opinions of Muslim religious leaders on domestic violence experienced by Muslim married women. This in turn highlighted the need for me to reflect carefully on my own assumptions about my insider status and take into account how prospective participants identify me as a researcher. For the study on which I am reflecting, I chose an interpretive research paradigm which falls under the umbrella of qualitative research. This research paradigm was necessary as it places emphasis on context and nuanced meanings …

How Doctoral Students With Low Gre Scores Succeed: A Grounded Theory Study, Dea Mulolli, June E. Gothberg

The Qualitative Report

Most U.S. graduate schools rely on the Graduate Record Examinations (GRE) to predict readiness for graduate degree programs and differentiate between applicants in verbal and quantitative reasoning, critical thinking, and analytical writing skills. Many times, low GRE scores create a barrier to entry into U.S. graduate programs despite research showing that selecting graduate applicants based solely on academic metric thresholds does not guarantee graduate student performance and many low scorers still attain a graduate degree on time (Miller et al., 2019b; Pacheco et al., 2017; Petersen et al., 2018; Wang et al, 2013). In this study, we used a constructivist …

Elafibranor Modulates Ileal Macrophage Polarization To Restore Intestinal Integrity In Nash: Potential Crosstalk Between Ileal Il-10/Stat3 And Hepatic Tlr4/Nf-Κb Axes, Andrew Hakeem, Mohamed M. Kamal, Rasha A. Radwan, Basma A. Abdelrahman, Olfat A. Hammam, Mohey M. Elmazar, Aiman S. El-Khatib, Yasmeen M. Attia

Pharmacy

Experimental and clinical evidence implicate disrupted gut barrier integrity in provoking innate immune responses, specifically macrophages, towards the progression of non-alcoholic steatohepatitis (NASH). Peroxisome proliferator-activated receptors (PPARs), a subset of the nuclear receptor superfamily, act to fine-tune several metabolic and inflammatory processes implicated in NASH. As such, the current study was carried out to decipher the potential role of dual PPAR α/δ activation using elafibranor (ELA) on ileal macrophage polarization (MP) and its likely impact on the liver in a NASH setting. To achieve this aim, an in vitro NASH model using fat-laden HepG2 cells was first used to validate …

Major Biochemical Constituents Of Withania Somnifera (Ashwagandha) Extract: A Review Of Chemical Analysis, Ekram Hany Mohamed, Mahmoud Tareq Abdelwahed,, Maha A. Hegazy

Pharmacy

Ashwagandha (Withania somnifera) is a very popular medicinal herb originated mainly in India and found in the Middle East and parts of Africa. Ashwagandha has gained recognition as the most revered plant in Ayurvedic medicine. Studies indicated that it is used as anxiolytic, anti-inflammatory, antioxidant, adaptogen, memory enhancer, and possess an effect on neurodegenerative diseases. Additionally, it was revealed that the plant exerts antibacterial, antiviral, antitumor, aphrodisiac, and cardiovascular protection activities. Due to the biological and nutritional importance of nutraceuticals, particularly ashwagandha, and as part of the ongoing research of the natural products and its bioactive phytochemicals, this review aims …

Hydroxysafflor Yellow A Protects Against Thioacetamide-Induced Liver Fibrosis In Rats Via Suppressing Proinflammatory/Fibrogenic Mediators And Promoting Hepatic Stellate Cell Senescence And Apoptosis, Sayed H. Seif El-Din Dr., Olfat A. Hammam Dr, Shahira M. Ezzat Dr, Samira Saleh Prof.Dr., Marwa M. Safa Dr., Walaa H. Elmaadawy Dr, Naglaa M. El-Lakkany Dr.

Pharmacy

Objective: To evaluate the effect of hydroxysafflor yellow A (HSYA) on thioacetamide-induced liver fibrosis. Methods: Thioacetamide was administered to rats intraperitoneally in doses of 200 mg/kg twice a week for 12 weeks. Thioacetamide intoxicated rats were given silymarin (50 mg/kg) or HSYA (5 mg/ kg) orally every day for 8 weeks. Liver enzymes, fibrosis markers, histological changes as well as immunohistochemistry of TNF-α, IL-6, p21, α-SMA, and caspase-3 were examined. The effect of HSYA on HSC-T6 activation/proliferation and apoptosis was also determined in vitro. Results: HSYA decreased liver enzymes, TNF-α, IL-6, and p21 expressions, hepatic PDGF-B, TIMP-1, TGF-β1, and hydroxyproline …

Africa Guidelines For Hepatocellular Carcinoma Buildup Process, Ghassan Abou-Alfa, Mary Afihene, Marinela Capanu, Joanne Chou, Akwi Asombang, Olusegun Alatise, Adda Bounedjar, Lina Cunha, Hailemichael Mekonnen, Papa Diop, Reda Elwakil, Mahamat Ali, Ntokozo Ndlovu, Jerry Ndumbalo, Precious Makondi, Christian Tzeuton, Tiago Castria, Adwoa Afrakoma Agyei-Nkansah, Fiyinfolu Balogun, Alain Bougouma, Blaise Ibara, Eduard Jonas, Stephen Kimani, Peter Kingham, Reshad Kurrimbukus, Nazik Hammad, Mona Fouad, Noha S. El Baghdady, Eloumou Fiacre, Vikash Sewram, C. Wendy Spearman, Ju Yang, Lewis Roberts, Ashraf Abdelaziz

Pharmacy

Abstract

Purpose

Hepatocellular carcinoma (HCC), the fourth most common cancer in Africa, has a dismal overall survival of only 3 months like in sub-Saharan Africa. This is affected by the low gross domestic product and human development index, absence of coherent guidelines, and other factors.

Methods

An open forum for HCC-experienced health care workers from Africa and the rest of the world was held in October 2021. Participants completed a survey to help assess the real-life access to screening, diagnoses, and treatment in the North and Southern Africa (NS), East and West Africa (EW), Central Africa (C), and the rest …

Comparative Hptlc Study For Simultaneous Determination Of Ivabradine And Metoprolol Using Uv And Fluorescence Detectors, Mohamed Rizk, Shereen Mowaka, Mariam Mohamed, Maha Abou El-Alamin

Pharmacy

New, simple, accurate, sensitive and validated high performance thin layer chromatographic (HPTLC) method coupled with UV absorbance mode and fluorescence (FL) detectors which were used for simultaneous determination of ivabradine (IVA) and metoprolol (MET) in their bulk and pharmaceutical dosage form using TLC silica 60 F254 plates and non-fluorescent TLC silica gel 60 plates. The developing system was chloroform: methanol: formic acid: ammonia (8.5:1.5:0.2:0.1, v/v). Desnitometric analysis in UV absorbance mode was set at λ = 275 nm. While, fluorescence mode was performed with excitation at 260 nm for quantitative simultaneous determination of IVA and MET using optical filter K320. …