Digital Commons Network^™

Cannabis-Assisted Psychotherapy For Complex Dissociative Posttraumatic Stress Disorder: A Case Report, Anya Ragnhildstveit, Miriam Kaiyo, Matthew Brian Snyder, Laura Kate Jackson, Alex Lopez, Chasity Mayo, Alyssa Claire Miranda, River Jude August, Paul Seli, Reid Robison, Lynnette Astrid Averill

Center for Medical Ethics and Health Policy Staff Publications

Background: A dissociative subtype of posttraumatic stress disorder, known as "D-PTSD", has been included in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. In addition to meeting criteria for PTSD, patients endorse prominent dissociative symptoms, namely depersonalization and derealization, or detachment from one's self and surroundings. At present, this population is supported by a highly heterogeneous and undeveloped literature. Targeted interventions are therefore lacking, and those indicated for PTSD are limited by poor efficacy, delayed onset of action, and low patient engagement. Here, we introduce cannabis-assisted psychotherapy (CAP) as a novel treatment for D-PTSD, drawing parallels to psychedelic …

Treatment And Life Goals Among Veterans With Gulf War Illness, Nicole Sullivan, Hannah Schorpp, Sarah Crosky, Scott Thien, Drew A Helmer, David R Litke, Wilfred R Pigeon, Karen S Quigley, Lisa M Mcandrew

Center for Medical Ethics and Health Policy Staff Publications

Medically unexplained syndromes (MUS), also termed persistent physical symptoms, are both prevalent and disabling. Yet treatments for MUS are marked by high rates of patient dissatisfaction, as well as disagreement between patients and providers on the management of persistent physical symptoms. A better understanding of patient-generated goals could increase collaborative goal setting and promote person-centered care, a critical component of MUS treatment; yet research in this area is lacking. This paper aimed to develop a typology of treatment and life goals among Gulf War veterans with a medically unexplained syndrome (Gulf War Illness). We examined participants’ responses to open-ended questions …

Clinician Perceptions Of Passport For Care, A Web-Based Clinical Decision Support Tool For Survivorship Care Plan Delivery, Jason E King, Michael C O'Connor, Ellen Shohet, Susan M Krause, Michael E Scheurer, Marc E Horowitz, David G Poplack, C Michael Fordis, Maria M Gramatges

Center for Medical Ethics and Health Policy Staff Publications

Background: The Children's Oncology Group Long-Term Follow-Up Guidelines provide exposure-based risks and recommendations for late effects screening of survivors of childhood cancer. Passport for Care (PFC) is a web-based clinical decision support tool for generating a personalized survivorship care plan (SCP) derived from the Guidelines and user-entered exposures. We assessed PFC clinician user practices and perceptions of PFC impact on clinic workflow, guidelines application, and survivor shared decision-making.

Procedure: A 35-item REDCap survey was emailed to all PFC users (n = 936) in 146 current and former PFC user clinics. Anonymous responses were permitted. Results were summarized and compared with …

5-Meo-Dmt For Post-Traumatic Stress Disorder: A Real-World Longitudinal Case Study, Anya Ragnhildstveit, Ryan Khan, Paul Seli, Lisa Claire Bass, River Jude August, Miriam Kaiyo, Nathaniel Barr, Laura Kate Jackson, Michael Santo Gaffrey, Joseph Peter Barsuglia, Lynnette Astrid Averill

Center for Medical Ethics and Health Policy Staff Publications

Psychedelic therapy is, arguably, the next frontier in psychiatry. It offers a radical alternative to longstanding, mainstays of treatment, while exciting a paradigm shift in translational science and drug discovery. There is particular interest in 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)—a serotonergic psychedelic—as a novel, fast-acting therapeutic. Yet, few studies have directly examined 5-MeO-DMT for trauma- or stress-related psychopathology, including post-traumatic stress disorder (PTSD). Herein, we present the first longitudinal case study on 5-MeO-DMT for chronic refractory PTSD, in a 23-year-old female. A single dose of vaporized bufotoxin of the Sonoran Desert Toad (Incilius alvarius), containing an estimated 10−15 mg …

Open-Source Statistical And Data Processing Tools For Wide-Field Optical Imaging Data In Mice, Lindsey M. Brier, Joseph P. Culver

2020-Current year OA Pubs

SIGNIFICANCE: Wide-field optical imaging (WOI) can produce concurrent hemodynamic and cell-specific calcium recordings across the entire cerebral cortex in animal models. There have been multiple studies using WOI to image mouse models with various environmental or genetic manipulations to understand various diseases. Despite the utility of pursuing mouse WOI alongside human functional magnetic resonance imaging (fMRI), and the multitude of analysis toolboxes in the fMRI literature, there is not an available open-source, user-friendly data processing and statistical analysis toolbox for WOI data.

AIM: To assemble a MATLAB toolbox for processing WOI data, as described and adapted to combine techniques from …

Powerful, Scalable And Resource-Efficient Meta-Analysis Of Rare Variant Associations In Large Whole Genome Sequencing Studies, Xihao Li, Corbin Quick, Hufeng Zhou, Sheila M. Gaynor, John Blangero, Joanne E. Curran, Ravindranath Duggirala, Harald H. H. Goring, Michael Mahaney, Juan M. Peralta

School of Medicine Publications

Meta-analysis of whole genome sequencing/whole exome sequencing (WGS/WES) studies provides an attractive solution to the problem of collecting large sample sizes for discovering rare variants associated with complex phenotypes. Existing rare variant meta-analysis approaches are not scalable to biobank-scale WGS data. Here we present MetaSTAAR, a powerful and resource-efficient rare variant meta-analysis framework for large-scale WGS/WES studies. MetaSTAAR accounts for relatedness and population structure, can analyze both quantitative and dichotomous traits and boosts the power of rare variant tests by incorporating multiple variant functional annotations. Through meta-analysis of four lipid traits in 30,138 ancestrally diverse samples from 14 studies of …

Sinonasal Outcomes Using Oral Corticosteroids In Patients With Chronic Rhinosinusitis With Nasal Polyps And Positive Sinonasal Cultures, Jhon F. Martinez Paredes, Angela M. Donaldson, Michael Marino, Garret Choby, Osarenoma Olomu, Razan Alfakir, Janalee K. Stokken, Erin O'Brien, Devyani Lal

School of Medicine Publications

Introduction: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and positive sinonasal bacterial cultures may be recalcitrant to topical therapy alone due to the additional local inflammatory burden associated with bacterial infection/colonization.

Objective: To evaluate sinonasal outcomes in CRSwNP patients with a positive perioperative bacterial culture, who were treated with postoperative intranasal corticosteroids (INCS) alone versus INCS in combination with a short-term course of oral corticosteroids (OCS).

Methods: This is a retrospective chart review of CRSwNP patients. A total of 59 patients met inclusion criteria, including positive perioperative bacterial culture and treatment with INCS with or without concomitant use of …

Serotonin Regulation Of Behavior Via Large-Scale Neuromodulation Of Serotonin Receptor Networks, Piergiorgio Salvan, Madalena Fonseca, Anderson M. Winkler, Antoine Beauchamp, Jason P. Lerch, Heidi Johansen-Berg

School of Medicine Publications

Although we understand how serotonin receptors function at the single-cell level, what role different serotonin receptors play in regulating brain-wide activity and, in turn, human behavior, remains unknown. Here, we developed transcriptomic–neuroimaging mapping to characterize brain-wide functional signatures associated with specific serotonin receptors: serotonin receptor networks (SRNs). Probing SRNs with optogenetics–functional magnetic resonance imaging (MRI) and pharmacology in mice, we show that activation of dorsal raphe serotonin neurons differentially modulates the amplitude and functional connectivity of different SRNs, showing that receptors’ spatial distributions can confer specificity not only at the local, but also at the brain-wide, network level. In humans, …

How Class Matters: Examining Working-Class Children’S Home Technology Environments From A Developmental Perspective, Vikki Katz, Brianna Hightower

Communication Faculty Articles and Research

Social class is seldom engaged by scholars as a lens for investigating variations in children’s digital technology engagement. Drawing on semi-structured interviews with 33 working-class children in a postindustrial community, we examine how social class shapes these children’s digital technology experiences. Bronfenbrenner’s ecological theory of child development guides our examination of children’s views on digital technology integration into their interactions with proximal influences (i.e., parents, siblings, and friends) and distal influences that indirectly shape their technology environments by affecting their parents’ circumstances. We find that working-class children’s experiences share key commonalities with both their lower- and higher-income peers, consistent with …

Proton Beam Therapy And Photon-Based Magnetic Resonance Image-Guided Radiation Therapy: The Next Frontiers Of Radiation Therapy For Hepatocellular Carcinoma, Michael Chuong

All Publications

External beam radiation therapy (EBRT) has increasingly been utilized in the treatment of hepatocellular carcinoma (HCC) due to technological advances with positive clinical outcomes. Innovations in EBRT include improved image guidance, motion management, treatment planning, and highly conformal techniques such as intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT). Moreover, proton beam therapy (PBT) and magnetic resonance image-guided radiation therapy (MRgRT) have expanded the capabilities of EBRT. PBToffers the advantage of minimizing low- and moderate-dose radiation to the surrounding normal tissue, thereby preserving uninvolved liver and allowing for dose escalation. MRgRT provides the advantage of improved soft tissue …

Gender Representation In Children's Media And Preschool-Aged Girls’ Internalized Beliefs About Gender, Jessica Lindsey Kanne Atkins

Graduate Theses/Dissertations

The current study examines patterns of gender representation through three categories (distribution, presentation, and stereotyped behaviors) in children’s media and how these patterns relate to preschool-aged girls’ internalized beliefs about gender. Both historical and presently available children’s media tends to display high levels of stereotypical gender representation. By preschool age, children have already developed distinctions between boys and girls, and hold internalized beliefs regarding gender. The objective of the current study is to examine the relationship between these two factors. To accomplish this, preschool-aged girls were interviewed to assess their internalized beliefs about gender. Their caregivers completed questionnaires related to …

Distribution Patterns Of Allorhizobium Vitis In Missouri Vineyards And Non-Vineyard Soils, Jacquelyn M. Wray

Graduate Theses/Dissertations

Crown gall disease causes significant economic loss to the grape and wine industry. Preventive strategies are most effective for mitigating the loss of grapevines in vineyards, as there is no known cure for this disease. The bacterium Allorhizobium vitis carrying a tumor-inducing (Ti) plasmid is the causative agent. A. vitis bacteria live systemically in the grapevine before causing visible symptoms and can survive in residual plant tissues and soil for more than two years. Diagnostic methods have been developed to detect A. vitis bacteria in grapevines and soil. However, more reliable, specific, and high-throughput diagnostics are still needed for screening …

Child Psychological Well-Being And Adult Health Behavior And Body Mass Index, Julia Boehm, Farah Qureshi, Laura D. Kubzansky

Psychology Faculty Articles and Research

Objective: Psychological well-being (PWB) is linked with health behaviors among adults, but it is unclear if childhood PWB prospectively predicts healthy adulthood biobehavioral profiles. Such evidence may identify developmental windows for establishing positive health trajectories across the lifespan. Using data spanning 30 years, we investigated whether PWB at age 11 was associated with health behaviors and body mass index (BMI) at ages 33 and 42. We hypothesized children with higher versus lower PWB would engage in healthier behaviors, have lower BMI in adulthood, and be more likely to maintain optimal levels over time. Method: Data were from 4,728 participants of …

The Scientific Study Of Positive Psychology, Religion/Spirituality, And Physical Health, Kevin S. Masters, Julia K. Boehm, Jennifer M. Boylan, Kaitlyn M. Vagnini, Christina L. Rush

Psychology Faculty Books and Book Chapters

Humans have long been interested in relations among religion/spirituality (R/S), positive psychological constructs, and physical health. Furthermore, many religions attempt to influence behavior through health-related prescriptions about food choices, sexual activity, substance use, and resting. Similarly, positive psychological constructs have been discussed in light of their presumed benefits on both mental and physical health (Ryff & Singer, 1998). However, R/S and positive psychological constructs have only recently become objects of scientific investigation of their associations with physical health.

Figure Set Update: An Inquiry-Based Module Aligned With The 4dee Framework For Teaching About Functional Responses And Biological Control, Rosny Jean, Linda Auker, Suann Yang, Jeremy Hsu

Open Educational Resources

THE ISSUE

Biological control agents are used in a wide range of contexts to limit damage from pests. However, the broader ecological consequences of such agents often are unclear before ecological risk assessments are performed. This Figure Set guides students to think through potential consequences of using biological control agents, and then uses a specific study to challenge students to interpret results from laboratory and caged field experiments. This Figure Set also introduces the concept of functional responses to students.

FOUR DIMENSIONAL ECOLOGY EDUCATION (4DEE) FRAMEWORK

• Core Ecological Concepts:
• Organisms
• Resources and regulators
• Communities
• Predation
• Ecology Practices:
• Quantitative reasoning and …

Estimating The Genetic Parameters Of Yield-Related 1 Traits Under Different Nitrogen Conditions In Maize, Semra Palali Delen, Gen Xu, Jenifer Velazquez-Perfecto, Jinliang Yang

Department of Agronomy and Horticulture: Faculty Publications

Understanding the genetic basis responding to nitrogen (N) fertilization in crop production is a long-standing research topic in plant breeding and genetics. Albeit years of continuous efforts, the genetic architecture parameters, such as heritability, polygenicity, and mode of selection, underlying the N responses in maize remain largely unclear. In this study, about n = 230 maize inbred lines were phenotyped under high N (HN) and low N (LN) conditions for two consecutive years to obtain six yield-related traits. Heritability analyses suggested that traits highly responsive to N treatments were less heritable. Using publicly available SNP genotypes, the genome-wide association study …

Teaching Agroecology: Preparing Students For Navigating Uncharted Territory, Charles A. Francis, Steve Gliessman

Department of Agronomy and Horticulture: Faculty Publications

Agroecologists understand that farming and food systems are more complex than the aggregation of their components. This realization drives our choices of learning strategies and activities that will prepare students for complexity and uncertainty. Our quest for a just, sustainable, and nutritious food system adequate to equitably serve everyone on the planet today and into the future is an enormous challenge. An undertaking of this magnitude will be met only with major adjustments informed by thoughtful teaching and practicing problem solving skills through a new educational lens. The principles of agroecology help us focus this lens on the wicked problems …

The Biggest Grower: A Youth Gardening Competition For Growing Specialty Crops And Urban Farmers, Stacy A. Adams, Terri James

Department of Agronomy and Horticulture: Faculty Publications

Youth today have tendencies for unhealthy lifestyles, being sedentary, consuming high fat diets low in fruits and vegetables, all contributing to child obesity, Type 2 diabetes, hypertension, and precedence for life-long health concerns. For rural and economically disadvantaged urban households, poor diet is directly attributed to the inaccessibility of fresh produce, affordability and understanding of preparation of various specialty crops. Through a grant from the NE Specialty Crop Block Funding Program, The Biggest Grower Competition (BGC) was developed as a summer extension education program for youth in 8^th through 12^th grade. Project goals included; provide educational materials on …

A Theory Of The Covid-19 Pandemic’S Impact On The Government-Citizen Relationship / Teorija Vpliva Pandemije Covid-19 Na Odnos Med Vlado In Državljani, Lewis Luartz

Political Science Faculty Articles and Research

This paper explores how crises, such as the COVID- 19 pandemic, can impact political behavior amid restrictions. Specifically, this paper builds a theoretical model suggesting the pandemic promoted restriction-oriented policies from the government in response to the crisis while promoting populist tendencies among citizens who disagree with those policies. Moreover, through a formal two-player extensive form game, the model promoted in this paper suggests restrictions are unpopular enough that citizens may push back on such policies regardless of crisis severity. The theoretical outcomes here have significant implications on governance, given that politicians care about re-election.

Self-Harm: Warning Signs, Risk Factors, And Prevention, Alina M. Baltazar

Faculty Publications

Rates of suicide and self-harm have been increasing in children and adolescents over the last 20 years (CDC, 2022). Suicidality and self-harm are preventable, treatable, and manageable. Parents and those who work with children, teens, and young adults are an important part in addressing this issue. This article reviews the current statistics of suicide and self-harm, role of trauma, risk-factors, causes, prevention, and treatment options. Practical tips and resources are included. The reader will better understand the phenomenon and know how self-harm and suicide can be prevented and treated.

Legitimate State Interest Or Educational Censorship: The Chilling Effect Of Oklahoma House Bill 1775, Jennie A. Hill

Oklahoma Law Review

No abstract provided.

Law License Reciprocity’S Discriminatory Exclusion Of Working Mothers, Sarah W. Keller

Oklahoma Law Review

No abstract provided.

Odd Man Out: The Survival Of Junior Lien Strip-Offs In Chapter 13 Following The Caulkett Decision, Theresa J. Pulley Radwan

Oklahoma Law Review

No abstract provided.

Critical Erase Theory: The Assault On Public School Curriculum, Brooks R. Cain

Oklahoma Law Review

No abstract provided.

The Work-Life Virus: Working From Home And Its Implications For The Gender Gap And Questions Of Intersectionality, Tammy Katsabian

Oklahoma Law Review

No abstract provided.

Three Ways To Sit Under A Shady Grove: The Uncertain Future Of The Oklahoma Citizens Participation Act In Federal Court, Nicholas Rinehart

Oklahoma Law Review

No abstract provided.

A Week To Prep, Two Minutes To Talk, And Two Days To Move: Why Oklahoma’S Eviction Courts Are Out Of Step With The Constitution, Adam H. Hines

Oklahoma Law Review

No abstract provided.

A Fine Mess: The Ncaa, The Collegiate Model, And The Post-Alston World, Josephine (Jo) R. Potuto

Oklahoma Law Review

No abstract provided.

Nil: The Title Iv Financial Aid Enigma, Kathryn Kisska-Schulze

Oklahoma Law Review

No abstract provided.

Investigation To Examine The Profile Of Auditory Brainstem And Hearing Thresholds Using Tone Burst Audiometry Brainstem Response In A Preclinical Migraine Model, Megan Huelsing

Graduate Theses/Dissertations

Migraine is a disabling neurological disease that is characterized by prominent auditory symptoms, including hyperacusis, which is defined as extreme sensitivity to sounds. The goal of this study was to investigate changes in hearing sensitivity and neural changes in the brainstem by measuring neural activity of the auditory brainstem in an established preclinical model of chronic migraine. To induce a chronic migraine state within the trigeminal system, male and female Sprague Dawley rats were subjected to three known human risk factors including neck muscle tension and REM sleep deprivation that promote latent sensitization, and exposure to a pungent odor, which …