Digital Commons Network^™

Scaling-Up Child And Youth Mental Health Services: Assessing Coverage Of A County-Wide Prevention And Early Intervention Initiative During One Fiscal Year, Cole Hooley, Deborah Salvo, Derek S Brown, Lauren Brookman-Frazee, Anna S Lau, Ross C Brownson, Patrick J Fowler, Debbie Innes-Gomberg, Enola K Proctor

2020-Current year OA Pubs

PURPOSE: In the U.S., the percentage of youth in need of evidence-based mental health practices (EBPs) who receive them (i.e., coverage rate) is low. We know little about what influences coverage rates. In 2010, the Los Angeles County Department of Mental Health (LACDMH) launched a reimbursement-driven implementation of multiple EBPs in youth mental health care. This study examines two questions: (1) What was the coverage rate of EBPs delivered three years following initial implementation? (2) What factors are associated with the coverage rates?

METHODS: To assess coverage rates of publicly insured youth, we used LACDMH administrative claims data from July …

Sox9 Governs Gastric Mucous Neck Cell Identity And Is Required For Injury-Induced Metaplasia, Spencer G Willet, Nattapon Thanintorn, Helen Mcneill, Sung-Ho Huh, David M Ornitz, Won Jae Huh, Stella G Hoft, Richard J Dipaolo, Jason C Mills

2020-Current year OA Pubs

BACKGROUND & AIMS: Acute and chronic gastric injury induces alterations in differentiation within the corpus of the stomach called pyloric metaplasia. Pyloric metaplasia is characterized by the death of parietal cells and reprogramming of mitotically quiescent zymogenic chief cells into proliferative, mucin-rich spasmolytic polypeptide-expressing metaplasia (SPEM) cells. Overall, pyloric metaplastic units show increased proliferation and specific expansion of mucous lineages, both by proliferation of normal mucous neck cells and recruitment of SPEM cells. Here, we identify Sox9 as a potential gene of interest in the regulation of mucous neck and SPEM cell identity in the stomach.

METHODS: We used immunostaining …

Size Distributions Of Intracellular Condensates Reflect Competition Between Coalescence And Nucleation, Daniel S W Lee, Chang-Hyun Choi, David W Sanders, Lien Beckers, Joshua A Riback, Clifford P Brangwynne, Ned S Wingreen

Faculty, Staff and Students Publications

Phase separation of biomolecules into condensates has emerged as a mechanism for intracellular organization and affects many intracellular processes, including reaction pathways through the clustering of enzymes and pathway intermediates. Precise and rapid spatiotemporal control of reactions by condensates requires tuning of their sizes. However, the physical processes that govern the distribution of condensate sizes remain unclear. Here we show that both native and synthetic condensates display an exponential size distribution, which is captured by Monte Carlo simulations of fast nucleation followed by coalescence. In contrast, pathological aggregates exhibit a power-law size distribution. These distinct behaviours reflect the relative importance …

Proceedings Of The 2023 Santa Fe Bone Symposium: Progress And Controversies In The Management Of Patients With Skeletal Diseases, E Michael Lewiecki, Teresita Bellido, John P Bilezikian, Jacques P Brown, Azeez Farooki, Christopher S Kovacs, Brendan Lee, William D Leslie, Michael R Mcclung, Mark L Prasarn, Deborah E Sellmeyer

Faculty, Staff and Students Publications

The Santa Fe Bone Symposium (SFBS) held its 23rd annual event on August 5-6, 2023, in Santa Fe, New Mexico, USA. Attendees participated in-person and remotely, representing many states and countries. The program included plenary presentations, panel discussions, satellite symposia, a Project ECHO workshop, and a session on healthcare policy and reimbursement for fracture liaison programs. A broad range of topics were addressed, including transitions of osteoporosis treatments over a lifetime; controversies in vitamin D; update on Official Positions of the International Society for Clinical Densitometry; spine surgery and bone health; clinical applications of bone turnover markers; basic bone biology …

Sphingolipids In Neurodegenerative Diseases, Xueyang Pan, Debdeep Dutta, Shenzhao Lu, Hugo J Bellen

Faculty, Staff and Students Publications

Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is affected in a surprisingly broad set of NDDs. These include some lysosomal storage diseases (LSDs), hereditary sensory and autonomous neuropathy (HSAN), hereditary spastic paraplegia (HSP), infantile neuroaxonal dystrophy (INAD), Friedreich’s ataxia (FRDA), as well as some forms of amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). Many of these diseases have been modeled in Drosophila melanogaster and are associated with elevated levels of ceramides. Similar changes have also been reported in vertebrate cells and mouse models. Here, we …

Development Of A Social And Environmental Determinants Of Health Informatics Maturity Model, Juan C Espinoza, Shruti Sehgal, Jimmy Phuong, Neil Bahroos, Justin Starren, Adam Wilcox, Daniella Meeker

2020-Current year OA Pubs

INTRODUCTION: Integrating social and environmental determinants of health (SEDoH) into enterprise-wide clinical workflows and decision-making is one of the most important and challenging aspects of improving health equity. We engaged domain experts to develop a SEDoH informatics maturity model (SIMM) to help guide organizations to address technical, operational, and policy gaps.

METHODS: We established a core expert group consisting of developers, informaticists, and subject matter experts to identify different SIMM domains and define maturity levels. The candidate model (v0.9) was evaluated by 15 informaticists at a Center for Data to Health community meeting. After incorporating feedback, a second evaluation round …

From A Boy To A Leader, Alejandro Zayas

Antioch University Dissertations & Theses

The following autoethnographic dissertation examines my personal experiences of trauma, abuse, and violence. Drawing on journals, memories, and artifacts from my life, I use self-reflection to illustrate the impacts of trauma on my childhood and adulthood. My traumatic experiences of sexual abuse, childhood violence, and emotional abuse are situated within broader sociocultural contexts of masculinity, Hispanic culture, and social norms. This study illuminates possibilities for healing and transformation for myself and others with shared traumatic backgrounds. It calls for trauma-informed education, masculinity, and resiliency. Evocatively sharing my traumatic life events provides an accessible window into often silenced experiences, bearing witness …

Does Anyone Else? The Lived Experience Of Writing About Depersonalization On Reddit, Kristina S. Fury

Antioch University Dissertations & Theses

As both The International Statistical Classification of Diseases and Related Health Problems 11th Revision (ICD-11) and The Diagnostic and Statistical Manual of Mental Disorders-5-Text Revision (DSM-5-TR) describe, depersonalization (DP) involves unpleasant episodes of detachment from one’s sense of self or of unreality in the environment. Symptoms include people feeling as though they are an outside observer of their thoughts, feelings, sensations, body, or actions. DP can take the form of emotional numbing, in which people may feel they are watching themselves from a distance or as though they are characters in a play. People can also feel physically numb, disconnected …

Landscaping Wellness At Work: A Participatory Model For Worker-Centered Health, Anya Helena Piotrowski

Antioch University Dissertations & Theses

This study contributes to a body of scholarship that demonstrates the benefits and need of employee-driven and defined wellness at work processes. This participatory action research study brought together a team of employees within a remote-work, start-up organization to define and design a process for implementing wellness at work for their organization. Through a participatory process that allowed outcomes to emerge from the group, employees identified opportunities to foster embodied wellness in their organization in three core areas: organizational, personal, and cross-boundary initiatives. Through a reflective collaboration, employees generated ideas and developed a plan to address employee-identified priorities that will …

Exploring The Definition Of Resilience: A Convergent Parallel Mixed Methods Study In Adults Over The Age Of 65, Sara J. Blessington

Antioch University Dissertations & Theses

The definition of a word helps us understand its context and how it is meant to be used in daily life or research. When a word lacks a universal definition, it is hard to know how to use it. “Resilience” is that type of word. The resilience community in psychological research does not have a concrete, universal definition for this word. It takes on whatever characteristics are useful to the investigator. This study began with seeking a universal definition for the domain known as resilience. This study used a convergent parallel design with adults aged 60 and older living independently …

Exploring The Lives Of Animal Activists: A Qualitative Study, Erin K. Mckenney

Antioch University Dissertations & Theses

The animal rights movement, despite its historical roots, has only recently garnered attention in the realm of social sciences, increasingly being recognized as a facet of social justice. This dissertation delves into the intersection of animal rights activism and gender, primarily focusing on the parallels drawn between the oppression of women and animals/nature. The noticeable dominance of women in the animal rights movement, as suggested by previous studies, formed the basis for adopting an eco-feminist approach to explore this issue, highlighting the shared oppression and exploitation faced by women and animals. In-depth, in-person interviews were used to collect data on …

The Use Of A Habitat Quality Stress Index To Evaluate Stress As An Analog For Proximate Fitness In The American Crow Within A Matrix Of Landcover Characteristics To Assess Its Potential Contribution To Disease Etiologies, Theodore Lee Grabarz

Antioch University Dissertations & Theses

All organisms occur within spatial and temporal environments to maximize proximate fitness (health) and thus life history outcomes. Previous work has examined the temporal and behavioral aspects of proximate fitness on life history outcomes particularly regarding highly perturbed environments (i.e., climate and land use change, resource extraction, agricultural erosion, etc.). My work focuses on the less examined spatial aspect of these perturbed environments. More specifically, this dissertation examines habitat selection and quality as the basis for understanding stress response (negative and positive feedback mechanisms) to environmental stressors within the larger context of regional or gamma (ɣ) biodiversity. Through the lens …

Adaptive Regulation For Ecosystem Restoration: A Context For Effective Environmental Permitting, Jennifer M. Auger

Antioch University Dissertations & Theses

This dissertation investigates the regulatory challenges faced by large-scale ecosystem restoration (LSER) projects by exploring the perspectives of practitioners and regulators. Focusing on the federal regulatory permitting process, the study aims to understand its impact on LSER projects and proposes the application of adaptive regulation for improvement. Employing Q methodology, participants expressed their views on 34 statements related to wetland permitting for LSER projects. Factor analysis revealed two distinct perspectives: Factor 1 emphasizes the reorganization of the permitting process within existing regulations, advocating for more documentation and structured processes. Factor 2 highlights the need for restructuring both the permitting process …

Intra-Articular Aav9 Α-L-Iduronidase Gene Replacement In The Canine Model Of Mucopolysaccharidosis Type I, Raymond Yu-Jeang Wang, Shih-Hsin Kan, Haoyue Zhang, Jodi D Smith, Afshin Aminian, Elizabeth Snella, Jackie K Jens, Sarah P Young, Patricia I Dickson, N Matthew Ellinwood

2020-Current year OA Pubs

Mucopolysaccharidosis type I (MPS I), an inherited lysosomal storage disorder characterized by deficiency of

Inhibition Of Mirna Associated With A Disease-Specific Signature And Secreted Via Extracellular Vesicles Of Systemic Lupus Erythematosus Patients Suppresses Target Organ Inflammation In A Humanized Mouse Model, Nicholas A Young, Emily Schwarz, Braden M Zeno, Shane Bruckner, Rosana A Mesa, Kyle Jablonski, Lai-Chu Wu, Elisha D O Roberson, Wael N Jarjour

2020-Current year OA Pubs

INTRODUCTION: Distinct, disease-associated intracellular miRNA (miR) expression profiles have been observed in peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematous (SLE) patients. Additionally, we have identified novel estrogenic responses in PBMCs from SLE patients and demonstrated that estrogen upregulates toll-like receptor (TLR)7 and TLR8 expression. TLR7 and TLR8 bind viral-derived single-stranded RNA to stimulate innate inflammatory responses, but recent studies have shown that miR-21, mir-29a, and miR-29b can also bind and activate these receptors when packaged and secreted in extracellular vesicles (EVs). The objective of this study was to evaluate the association of EV-encapsulated small RNA species in SLE …

Large-Scale Exome Array Summary Statistics Resources For Glycemic Traits To Aid Effector Gene Prioritization, Sara M. Willems, Ping An, Michael A. Province, Et Al.

2020-Current year OA Pubs

No abstract provided.

An Overview Of Blood-Based Biomarkers In Ad, Steve Pedrini

Theses: Doctorates and Masters

Alzheimer’s disease (AD) is the most common form of dementia in the elderly whose main neuropathological features are the presence of extracellular senile plaques in the brain and the intracellular accumulation of hyperphosphorylated tau filaments. However, a relatively cheap and non-invasive method for the diagnosis of AD remains elusive. Recent studies have indicated that cerebral biochemical changes take place decades before the clinical onset of the disease, but current methodologies, brain scan (PET amyloid imaging) and cerebrospinal fluid (CSF) analysis, are unsuited for community-wide screening. Brain scanning methods non-invasively assess amyloid load but are extremely expensive and cannot be used …

Comparative Study On Development Of Novel Catalytic Oxidation For Removing Emerging Contaminants, Abdul H. Asif

Theses: Doctorates and Masters

‘Wastewater treatment’ is not itself a new concept, where global water bodies have been polluted since the evolution of mankind. As a result of human activities including domestic, industrial and commercial practices, levels of water pollution through aqueous contaminants are increasing every day. Moreover, rapid industrialisation and recent human progress has given rise to a new classification of pollution, that of emerging contaminants (ECs). Further, these chemicals are highly resistant to biodegradation and are capable of travelling, where they can penetrate from one part of the world to another. Whilst traditional wastewater treatment techniques, such as adsorption, might be effective …

Woman-Centred Ethics: A Feminist Participatory Action Research, Katherine A. Buchanan

Theses: Doctorates and Masters

Background: The maternity system has a complexity of everyday ethical issues. The bioethical principles: non maleficence, beneficence justice and autonomy, that govern health care practice have been criticised as abstract, patriarchal and even rhetorical in maternity care practice (MacLellan, 2014) and consequently may be insufficient in guiding care of childbearing women. Midwifery-led care is guided by the International Confederation of Midwives International Code of Ethics, which considers more than the bioethical principles, such as the importance of relationship. Care ethics is a relational based feminist ethics first described by Gilligan (1983) and has been theorised as an alternate paradigm for …

Psycho-Spiritual Counselling To Enhance Resiliency As Transformative Education: An Auto/Ethnographic Inquiry Of The Interface Between Spirituality And Positive Psychology, Dominic Savio

Theses: Doctorates and Masters

This thesis attempts to capture my lived experiences of psychospiritual counselling and to describe how my research journey has shaped me personally and professionally. As a priest engaged in psychospiritual counselling internationally for nearly three decades in diverse settings, I attempt to seek further clarity and make sense of my rich experiences in this research. Therefore, I endeavoured to investigate if and how building resiliency through psychospiritual counselling can be comprehended as transformative education.

Experientially speaking, as a priest and psychospiritual counsellor, I recognised that people leaned on their moral vulnerabilities and were blinded to spirituality as a source of …

Comparing Western Australia And South Australia Public High School’S Cyberbullying Policies – Is There A Need For A Legislative Change, Vanessa Tay

Theses: Doctorates and Masters

The internet provides some of the most effective means of communication. Cyberbullying occurs when the internet is used to bully another person. Along with the positive aspects of the internet, cyberbullying is certainly one of the most negative aspects, especially with regard to school students. Victims of cyberbullying may be able to obtain legal sanctions, however, this usually occurs after the harm is done. In Australia, some states such as South Australia have recognised the need for preventive strategies by requiring schools to have an anti-bullying plan in place. Other countries, like Ontario, Canada have implemented similar preventative strategies in …

Improvement In The Capacity For Activity Versus Improvement In Performance Of Activity In Daily Life During Outpatient Rehabilitation, Catherine E. Lang, Carey L. Holleran, Michael J. Strube, Terry D. Ellis, Caitlin A. Newman, Meghan Fahey, Tamara R. Deangelis, Timothy J. Nordahl, Darcy S. Reisman, Gammon M. Earhart, Keith R. Lohse, Marghuretta D. Bland

2020-Current year OA Pubs

UNLABELLED: We addressed questions about the potential discrepancy between improvements in activity capacity and improvements in activity performance in daily life. We asked whether this discrepancy is: 1. Common in routine, outpatient care, or an artifact of intervention studies? 2. Unique to upper limb (UL) rehabilitation, or is it seen in walking rehabilitation too? 3. Only seen in persons with stroke, or a broader neurorehabilitation problem?

METHODS:: A longitudinal, observational cohort of 156 participants with stroke or Parkinson disease (PD) receiving outpatient rehabilitation at 5 clinics was assessed around admission and monthly during their episode of care. Individual, longitudinal capacity …

Lymphatic Contractile Dysfunction In Mouse Models Of Cantú Syndrome With Katp Channel Gain-Of-Function, Michael J Davis, Jorge A Castorena-Gonzalez, Hae Jin Kim, Min Li, Maria Remedi, Colin G Nichols

2020-Current year OA Pubs

Cantú Syndrome (CS) is an autosomal dominant disorder caused by gain-of-function (GoF) mutations in the Kir6.1 and SUR2 subunits of K

Australian Churches During Coronatide: Lessons & Opportunities, Pieter-Jan Bezemer, Sten Langmann

Research outputs 2022 to 2026

Christian churches have played a pivotal role in the social and economic fabric of many Western countries over centuries. However, in many of these countries national censuses have revealed significant declines in the number of people that associate themselves with Christianity. For example, the latest census of the Australian Bureau of Statistics revealed that in 2021 less than half of the population was still affiliated with Christianity. This gradual but steady decline has had a significant impact on churches, as it has become more challenging to maintain church communities and church buildings, and serve the wider community. Early in 2020, …

Plasma And Cerebrospinal Fluid Proteomic Signatures Of Acutely Sleep-Deprived Humans: An Exploratory Study, Ana Vaquer-Alicea, Jinsheng Yu, Haiyan Liu, Brendan P Lucey

2020-Current year OA Pubs

STUDY OBJECTIVES: Acute sleep deprivation affects both central and peripheral biological processes. Prior research has mainly focused on specific proteins or biological pathways that are dysregulated in the setting of sustained wakefulness. This exploratory study aimed to provide a comprehensive view of the biological processes and proteins impacted by acute sleep deprivation in both plasma and cerebrospinal fluid (CSF).

METHODS: We collected plasma and CSF from human participants during one night of sleep deprivation and controlled normal sleep conditions. One thousand and three hundred proteins were measured at hour 0 and hour 24 using a high-scale aptamer-based proteomics platform (SOMAscan) …

Case Report: Peptide Receptor Radioligand Therapy In Metastatic Pediatric Neuroendocrine Tumors, Khanyisile Hlongwa, Olumayowa Kolade, Abdulilah Alnabulsi, Rachelle Steyn, Anita Brink, Vikas Prasad, Stuart More

2020-Current year OA Pubs

Neuroendocrine tumors (NETs) are not commonly diagnosed in children. Metastatic NETs tend to have poor outcomes, and this is seen in adult and pediatric populations. The role of somatostatin receptor imaging using [

Impact Of Multi-Source Data Augmentation On Performance Of Convolutional Neural Networks For Abnormality Classification In Mammography, Inchan Hwang, Hari Trivedi, Beatrice Brown-Mulry, Linglin Zhang, Vineela Nalla, Aimilia Gastounioti, Judy Gichoya, Laleh Seyyed-Kalantari, Imon Banerjee, Minjae Woo

2020-Current year OA Pubs

INTRODUCTION: To date, most mammography-related AI models have been trained using either film or digital mammogram datasets with little overlap. We investigated whether or not combining film and digital mammography during training will help or hinder modern models designed for use on digital mammograms.

METHODS: To this end, a total of six binary classifiers were trained for comparison. The first three classifiers were trained using images only from Emory Breast Imaging Dataset (EMBED) using ResNet50, ResNet101, and ResNet152 architectures. The next three classifiers were trained using images from EMBED, Curated Breast Imaging Subset of Digital Database for Screening Mammography (CBIS-DDSM), …

The Political Economy Of Due Diligence Legislation, Peter Draper, Andreas Freytag, Naoise Mcdonagh, Matthias Menter

Research outputs 2022 to 2026

The policy challenge. Citizens and politicians in Western democracies have increasingly become aware of the importance of human rights, civil liberties, social rights, and sustainability issues as well as the different adherence to basic rights (such as equal treatment) all over the world. This trend has recently materialized in laws in the United States (US), Europe, Australia, and elsewhere. To varying extents, these oblige domestic businesses to comply with, and enforce, Western values and standards along their international supply chains. This values-based due diligence legislation has caused ongoing controversies over compliance costs, impacts on foreign relations – particularly with developing …

Kids, Courts And Canines: An Evaluation Of The Justice Facility Dog Pilot Program In Perth's Children's Court, Suzanne Rock, Natalie Gately

Research outputs 2022 to 2026

The Justice Facility Dog Pilot Program (JFDPP) was introduced to Perth Children's Court, Western Australia in September 2021 to improve the wellbeing of victims, witnesses and other Court users attending the Court for criminal or child protection matters.

As requested by the Office for the Commissioner of Victims of Crime, the program was evaluated by independent researchers from Edith Cowan University. The project was funded by ECU and Partial funding was sought and granted by the Western Australian Office of Crime Statistics and Research Criminal Justice Grant scheme to facilitate the evaluation (See Appendix J).

Short surveys were conducted at …

A Narrative Inquiry Of Latinx Undergraduates' Participation In High-Impact Educational Practices, Sarah R. Villarreal

Antioch University Dissertations & Theses

There are systematic barriers to educational equity in the U.S. higher education system, and the system overwhelmingly fails Latinx undergraduates more often than other students. It is crucial that evidence-based methods be used to reduce the existing postsecondary student success inequities. Scholars have linked specific educational practices to positive learning effects. A growing body of evidence has suggested these educational practices, coined high-impact practices (HIPs), provide amplified benefits to historically underserved students (HUS) and may be an effective tool for advancing equity and closing achievement gaps. The extant literature has neither adequately explained the reason(s) that HIPs provide an academic …